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Acute Anterior Uveitis

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https://www.readbyqxmd.com/read/29345511/clinical-characteristics-of-herpes-simplex-virus-associated-anterior-uveitis
#1
Barbara Wensing, Manabu Mochizuki, Joke H De Boer
PURPOSE: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis. METHODS: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. RESULTS: It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females...
January 18, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29344060/neuro-ophthalmic-presentation-of-neuro-sweet-disease
#2
Padmaja Sudhakar, Stuart Tobin, William O Connor, Sachin Kedar
Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Years later, he developed acute posterior multifocal placoid pigment epitheliopathy...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29260064/bilateral-uveitis-following-intravenous-immunoglobulin-administration
#3
Enis D Kocak, Bob Z Wang, Anthony J Hall
Purpose: To report a case of bilateral acute anterior uveitis in an adult female occurring following the administration of intravenous immunoglobulin (IVIG). Observations: A 44-year-old female patient was commenced on IVIG following presentation to hospital with upper limb neuropathic pain. Within two days, she developed bilateral red, painful photophobic eyes. Examination revealed bilateral acute anterior uveitis and IVIG was ceased. Investigations for autoimmune or infective causes for the uveitis were unremarkable...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260047/bilateral-acute-simultaneous-onset-anterior-uveitis-presumed-secondary-to-erlotinib-a-report-of-two-cases
#4
Kendra A Klein, Christopher G Azzoli, Lana M Rifkin
Purpose: To report two new cases of presumed erlotinib-associated bilateral acute simultaneous-onset anterior uveitis effectively treated with topical steroids. Observations: Two patients were referred to the uveitis clinic with bilateral acute simultaneous onset, anterior uveitis six weeks after starting the chemotherapeutic agent erlotinib. Frequent topical steroid were started and the inflammation responded swiftly and completely. Conclusions and importance: Bilateral acute simultaneous onset anterior uveitis is a potential side effect associated with erlotinib use that has not been well described...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29210959/acute-frosted-retinal-periphlebitis-in-a-patient-with-mediterranean-fever
#5
Köse Özlem, Willermain François, Caspers Laure, Postelmans Laurence, El Ouardighi Hind, Guillaume Marie-Paule, Makhoul Dorine
PURPOSE: To present a case of frosted branch periphlebitis in a young Armenian patient with familial Mediterranean fever. METHODS: Case report. RESULTS: A 37-year-old man presented with a unilateral decreased visual acuity and floaters for 4 days on the left eye (LE). Visual acuity was 20/20 in the right eye (RE) and 20/28 in the LE. Anterior segment and fundus examinations of the RE were normal. Slit-lamp examination of LE revealed a mild nongranulomatous anterior uveitis and vitritis...
November 23, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29191218/analysis-of-choroidal-and-central-foveal-thicknesses-in-acute-anterior-uveitis-by-enhanced-depth-imaging-optical-coherence-tomography
#6
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
BACKGROUND: Currently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses during episodes of AAU. METHODS: The medical records of 120 patients with AAU and 120 healthy subjects matched for age, sex, and spherical equivalent of refractive error were reviewed. Subjects were divided into group 1 (AAU-affected eyes), 2 (unaffected fellow eyes), and 3 (healthy control eyes)...
December 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29176536/paracentral-acute-middle-maculopathy-associated-with-bilateral-optic-disk-swelling-and-meningitis
#7
Zhenyang Zhao, Parker Faith, Kaivon Pakzad-Vaezi, Zhongdi Chu, Ruikang K Wang, Raghu C Mudumbai, Kasra A Rezaei
BACKGROUND/PURPOSE: To present a novel case of paracentral acute middle maculopathy associated with bilateral optic disk swelling. METHODS: Retrospective case report. RESULTS: A 67-year-old woman presented with sudden onset of central vision loss and subsequent bilateral optic disk edema, retinal vessel attenuation, and anterior uveitis. Cerebrospinal fluid analysis showed signs of inflammation. Spectral domain optical coherence tomography demonstrated the pathognomonic hyperreflectivity of the middle retinal layers consistent with paracentral acute middle maculopathy...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29172842/review-for-disease-of-the-year-clinic-of-cytomegalovirus-induced-anterior-uveitis
#8
Nicole Shu-Wen Chan, Soon-Phaik Chee, Laure Caspers, Bahram Bodaghi
Cytomegalovirus (CMV) anterior uveitis is the most common ocular manifestation of CMV disease in immunocompetent individuals. It is thought to be due to a local reactivation of latent CMV and is usually unilateral. The acute form presents as Posner-Schlossman Syndrome, a recurrent hypertensive anterior uveitis with few granulomatous keratic precipitates. There are geographic differences in the chronic form of CMV anterior uveitis. Asian patients commonly present as Fuchs Uveitis Syndrome with diffuse stellate keratic precipitates, while the European patients present with a chronic hypertensive anterior uveitis with fewer keratic precipitates that are brown in color and located inferiorly...
November 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29122311/-uveitis-diagnostic-work-up-recommendations-from-an-expert-committee
#9
P Sève, B Bodaghi, S Trad, J Sellam, D Bellocq, P Bielefeld, D Sène, G Kaplanski, D Monnet, A Brézin, M Weber, D Saadoun, P Cacoub, C Chiquet, L Kodjikian
INTRODUCTION: Diagnostic work-up of uveitis involves many uncertainties. Search for an etiology should take into account the epidemiology of uveitis and focus on the most severe diseases or those, which can be treated. This work was undertaken to establish recommendations for the diagnosis work-up of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 15 experts, including internists, ophthalmologists and a rheumatologist and are based on a review of the literature with regard to effectiveness of investigations and the results of the ULISSE study, which is the first prospective study assessing the efficiency of a standardized strategy for the etiological diagnosis of uveitis...
November 6, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29093157/sacroiliac-joint-magnetic-resonance-imaging-in-asymptomatic-patients-with-recurrent-acute-anterior-uveitis-a-proof-of-concept-study
#10
Thauana L Oliveira, Walter P Maksymowych, Robert G W Lambert, Cristina Muccioli, Artur R C Fernandes, Marcelo M Pinheiro
OBJECTIVE: Our aim was to quantify bone marrow edema (BME) and/or structural lesions in the sacroiliac joints (SIJ) of patients with recurrent acute anterior uveitis (rAAU) with or without back pain, to evaluate the frequency of axial (axSpA) and peripheral spondyloarthritis (pSpA) and to establish which criterion for magnetic resonance imaging (MRI) positivity best reflected the global assessment of SIJ MRI. METHODS: A total of 50 patients with rAAU without prior rheumatologic diagnosis were included in our cross-sectional study, and these patients were compared to 21 healthy volunteers...
December 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29037906/uveitis-diagnostic-work-up-a-literature-review-and-recommendations-from-an-expert-committee
#11
REVIEW
Pascal Sève, Patrice Cacoub, Bahram Bodaghi, Salim Trad, Jérémie Sellam, David Bellocq, Philip Bielefeld, Damien Sène, Gilles Kaplanski, Dominique Monnet, Antoine Brézin, Michel Weber, David Saadoun, Christophe Chiquet, Laurent Kodjikian
PURPOSE: Diagnosis of uveitis is difficult. Etiologic investigations should take into account the epidemiology of uveitis and should focus on the most severe forms of the disease and those which can be treated. This study was undertaken to establish recommendations for the diagnosis of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 14 experts, including internists, ophthalmologists, and rheumatologists, and are based on a review of the literature and the results of the ULISSE study, which was the first prospective study to assess the efficacy of a standardized strategy for the etiologic diagnosis of uveitis...
December 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29020487/clinical-characteristics-and-prognostic-factors-in-ankylosing-spondylitis-associated-uveitis
#12
Ji Hwan Lee, Moonjung Choi, Tyler Hyung Taek Rim, Sung Chul Lee, Christopher Seungkyu Lee
PURPOSE: To identify the clinical features and prognostic factors of uveitis associated with ankylosing spondylitis (AS). METHODS: This retrospective, interventional case series study reviewed the medical records of 91 AS patients with uveitis. RESULTS: The characteristics of AS-associated uveitis included male preponderance (70%), average onset in the fourth decade, unilateral manifestation (87.9%), and vitreous involvement or retinal vascular leakage (36...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28973324/mapping-retinal-and-choroidal-thickness-in-unilateral-nongranulomatous-acute-anterior-uveitis-using-three-dimensional-1060-nm-optical-coherence-tomography
#13
Maximilian Gabriel, Robert Kruger, Farnusch Shams-Mafi, Boris Hermann, Behrooz Zabihian, Leopold Schmetterer, Wolfgang Drexler, Susanne Binder, Marieh Esmaeelpour
Purpose: To analyze retinal thickness (RT) and choroidal thickness (ChT) changes in patients with unilateral nongranulomatous acute anterior uveitis (AAU) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT). Methods: Retinal and choroidal thickness maps were statistically analyzed for 24 patients with newly diagnosed unilateral AAU before therapy. A total of 17 patients were followed until resolution of inflammatory activity (twice in the first week, then weekly)...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28937830/simvastatin-as-an-adjunct-to-conventional-therapy-of-non-infectious-uveitis-a-randomized-open-label-pilot-study
#14
Ivan V Shirinsky, Anastasia A Biryukova, Valery S Shirinsky
PURPOSE: Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvastatin in patients with uveitis. METHODS: For this single-center, open-label, randomized study, we enrolled patients with acute non-infectious uveitis...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28871477/-diagnostics-and-management-of-herpes-zoster-ophthalmicus
#15
R N Werner, N-I Steinhorst, A Nast, U Pleyer
Herpes zoster (HZ, shingles) represents the secondary manifestation of an infection with varicellazoster virus (VZV). A reactivation of dormant VZV in the ophthalmic branch of the fifth cranial nerve leads to ophthalmic HZ (HZO). The predominantly older and immune compromised patients often present with eye involvement (approximately 50%) as well as characteristic skin changes. Clinical manifestations include the cornea and conjunctiva but anterior uveitis and (rarely) acute retinal necrosis may also occur...
October 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28861674/-ocular-involvement-in-rheumatoid-arthritis-connective-tissue-diseases-and-vasculitis
#16
REVIEW
I Kötter, N Stübiger, C Deuter
There are many interfaces between ophthalmologists and rheumatologists. On the one hand ophthalmologists face the question if an inflammation of the eye is caused by systemic inflammatory rheumatic diseases and on the other hand rheumatologists have to consider that ocular manifestations are relatively common in some inflammatory rheumatic diseases. Furthermore, these ocular manifestations may influence therapeutic decisions of the rheumatologist. This article summarizes which ocular inflammations can be associated with rheumatoid arthritis, connective tissue diseases and vasculitides...
October 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28853536/impact-of-uveitis-on-quality-of-life-a-prospective-study-from-a-tertiary-referral-rheumatology-ophthalmology-collaborative-uveitis-center-in-italy
#17
Claudia Fabiani, Antonio Vitale, Ida Orlando, Marco Capozzoli, Fiorella Fusco, Francesco Rana, Rossella Franceschini, Jurgen Sota, Bruno Frediani, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
BACKGROUND: Non-infectious uveitis (NIU) leads to severe visual impairment, potentially impacting on health-related quality of life (QoL). OBJECTIVES: To investigate the impact of NIU on QoL. METHODS: Eighty NIU patients and 23 healthy controls completed the 36-item Short-Form Health Survey (SF)-36. The SF-36 values were statistically analyzed to evaluate differences between patients and healthy controls and to identify correlations between SF-36 subscores and clinical/demographic data...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28852187/in-vivo-confocal-microscopy-of-posner-schlossman-syndrome-comparison-with-herpes-simplex-keratitis-hla-b27-anterior-uveitis-and-acute-attack-of-primary-angle-closure
#18
Ying Hong, Miao Wang, Lingling Wu
To investigate in vivo confocal microscopy (IVCM) findings in patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM findings from the eyes of patients with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 eyes); HLA-B27 anterior uveitis (B27AU) (45 eyes); and with acute attack of primary angle closure (aPAC) (43 eyes). The central Langerhans cells (LCs) grade at the level of corneal basal epithelial cells of the PSS group (2.33 ± 0.55) was similar to that of the HSK group (2.63 ± 0...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837372/update-upon-efficacy-and-safety-of-etanercept-for-the-treatment-of-spondyloarthritis-and-juvenile-idiopathic-arthritis
#19
Giuseppe Murdaca, Simone Negrini, Ottavia Magnani, Elena Penza, Marco Pellecchio, Rossella Gulli, Paola Mandich, Francesco Puppo
TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis (AS), psoriasis (Ps) and/or psoriatic arthritis (PsA) and may be administered off-label to treat disseminated granuloma annulare, systemic lupus erythematosus and systemic sclerosis. There are several TNF-α inhibitors available for clinical use including infliximab, adalimumab, golimumab, certolizumab pegol and etanercept...
August 24, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28825765/impact-of-uveitis-on-quality-of-life-a-prospective-study-from-a-tertiary-referral-rheumatology-ophthalmology-collaborative-uveitis-center-in-italy
#20
Claudia Fabiani, Antonio Vitale, Ida Orlando, Marco Capozzoli, Fiorella Fusco, Francesco Rana, Rossella Franceschini, Jurgen Sota, Bruno Frediani, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
BACKGROUND: Non-infectious uveitis (NIU) leads to severe visual impairment, potentially impacting on health-related quality of life (QoL). OBJECTIVES: To investigate the impact of NIU on QoL. METHODS: Eighty NIU patients and 23 healthy controls completed the 36-item Short-Form Health Survey (SF)-36. The SF-36 values were statistically analyzed to evaluate differences between patients and healthy controls and to identify correlations between SF-36 subscores and clinical/demographic data...
August 2017: Israel Medical Association Journal: IMAJ
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