Karin Pelka, Matan Hofree, Jonathan H Chen, Siranush Sarkizova, Joshua D Pirl, Vjola Jorgji, Alborz Bejnood, Danielle Dionne, William H Ge, Katherine H Xu, Sherry X Chao, Daniel R Zollinger, David J Lieb, Jason W Reeves, Christopher A Fuhrman, Margaret L Hoang, Toni Delorey, Lan T Nguyen, Julia Waldman, Max Klapholz, Isaac Wakiro, Ofir Cohen, Julian Albers, Christopher S Smillie, Michael S Cuoco, Jingyi Wu, Mei-Ju Su, Jason Yeung, Brinda Vijaykumar, Angela M Magnuson, Natasha Asinovski, Tabea Moll, Max N Goder-Reiser, Anise S Applebaum, Lauren K Brais, Laura K DelloStritto, Sarah L Denning, Susannah T Phillips, Emma K Hill, Julia K Meehan, Dennie T Frederick, Tatyana Sharova, Abhay Kanodia, Ellen Z Todres, Judit Jané-Valbuena, Moshe Biton, Benjamin Izar, Conner D Lambden, Thomas E Clancy, Ronald Bleday, Nelya Melnitchouk, Jennifer Irani, Hiroko Kunitake, David L Berger, Amitabh Srivastava, Jason L Hornick, Shuji Ogino, Asaf Rotem, Sébastien Vigneau, Bruce E Johnson, Ryan B Corcoran, Arlene H Sharpe, Vijay K Kuchroo, Kimmie Ng, Marios Giannakis, Linda T Nieman, Genevieve M Boland, Andrew J Aguirre, Ana C Anderson, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals. Analysis of 88 cell subsets and their 204 associated gene expression programs revealed extensive transcriptional and spatial remodeling across tumors...
September 2, 2021: Cell