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Portal vein invasion

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https://www.readbyqxmd.com/read/29124894/combined-transcatheter-arterial-chemoembolization-and-radiofrequency-ablation-in-single-session-for-solitary-hepatocellular-carcinoma-larger-than-7%C3%A2-cm
#1
Jie-Yu Yan, Jin-Long Zhang, Mao-Qiang Wang, Kai Yuan, Yan-Hua Bai, Yan Wang, Hai-Nan Xin, Zhi-Jun Wang, Feng-Yong Liu, Feng Duan, Jin-Xin Fu
AIMS: To evaluate technical feasibility and treatment results of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in single-session for solitary hepatocellular carcinoma (HCC) larger than 7 cm in diameter. METHODS: Institutional review board approved this retrospective study. Written informed consent was obtained from all patients. Between June 2007 and July 2013, 87 patients (75 men, 12 women; mean age, 55.5 years ± 15...
November 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29108283/combination-of-sorafenib-and-tace-inhibits-portal-vein-invasion-for-intermediate-stage-hcc-a-single-center-retrospective-controlled-study
#2
Qi Yao, Hongsen Zhang, Bin Xiong, Chuansheng Zheng
Purpose: This study aims to investigate the effect of sorafenib plus Transarterial Chemoembolization (TACE) treatment on inhibiting portal vein invasion in patients with intermediate stage HCC. Materials and Methods: The consecutive medical records of patients with HCC were retrospectively analyzed from October 2009 to February 2015. The propensity score matching method was applied into group matching. The Kaplan-Meier method and the Log-Rank Test was used to estimate the median survival time, median time to progression and median time to portal vein invasion...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097158/induction-of-liver-proliferation-using-a-polymeric-platform-in-mice
#3
Marcela Guimarães Takahashi de Lazari, Luciana Xavier Pereira, Celso Tarso Rodrigues Viana, Laura Alejandra Ariza Orellano, Simone Aparecida de Almeida, Anilton Cesar Vasconcelos, Giani Barbosa Ribeiro, Leticia Chinait Couto, Silvia Passos Andrade, Paula Peixoto Campos
AIMS: Currently, animal models of liver regeneration are based on extensive lesions of the native organ and on cellular approaches using biomaterials to host growth factors and extracellular components to create artificial liver systems. We report a polymeric biological platform, minimally invasive, that induced sequential proliferation of liver parenchyma inside the scaffold in mice. MAIN METHODS: Porous discs of polyether-polyurethane were surgically placed under the left liver lobe and removed at days 4, 8, 12 and 25 after implantation...
October 31, 2017: Life Sciences
https://www.readbyqxmd.com/read/29079182/a-case-of-a-primary-hepatic-so-called-adenosarcoma-with-heterotopic-ossification-possibly-of-biliary-adenofibroma-origin
#4
Shiori Meguro, Satoru Yamazaki, Sayomi Matsushima, Kazuhito Kawata, Hideya Kawasaki, Takashi Tsuchida, Isao Kosugi, Yoshimasa Kobayashi, Satoshi Baba, Toshihide Iwashita
We present an autopsy case of a "so-called adenosarcoma with ossification of the liver" in a 63-year old man. Macroscopically, the well-circumscribed tumor with portal vein invasion was observed in the right lobe of the liver. The cut surface of the tumor had a solid and microcystic appearance. Microscopically, the tumor was characterized by a benign epithelial component and a malignant mesenchymal component. We believe the presence of biliary adenofibroma like areas and the von Meyenburg complexes suggests that the tumor is possibly associated with a biliary adenofibroma...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29055930/analysis-of-the-meld-score-impact-in-the-outcome-of-endovascular-portal-vein-reconstruction
#5
Adriana Torres-Machorro, Manuel Guerrero-Hernandez, Javier E Anaya-Ayala, Aldo Torre, Hugo Laparra-Escareno, Cesar Cuen-Ojeda, Ramón Garcia-Alva, Carlos A Hinojosa
INTRODUCTION: Endovascular therapy represents a less invasive alternative to open surgery for reconstruction of the portal vein (PV) and the spleno-mesenteric venous confluence to treat Portal hypertension. The objective of this study is to determine if the Model for End-Stage Liver Disease (MELD) score is a useful method to evaluate the risk of morbidity and mortality during endovascular approaches. MATERIAL AND METHODS: Patients that underwent endovascular reconstruction of the PV or spleno-mesenteric confluence were identified retrospectively...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29051395/role-of-computer-tomography-and-endoscopic-ultrasonography-in-assessing-portal-and-superior-mesenteric-vessels-invasion-in-cephalo-pancreatic-adenocarcinoma
#6
Raluca Bodea, Andrada Seicean, Tudor Vasile, Tudor Calinici, Irina Ciuca, Nadim Al Hajjar, Cornel Iancu, Constantin Iordache
AIM: The aim of this study is to evaluate the information given by contrast-enhanced computer tomography (CECT) and ultrasound endoscopy (EUS) regarding vascular involvement of cephalo-pancreatic cancer, data compared with intraoperative findings. MATERIAL AND METHODS: We choose to analyze the most often interested vessels by tumor development, such as superior mesenteric artery (SMA), superior mesenteric vein (SMV) and portal vein (PV). The patients included in the study (n=425) had a cephalo-pancreatic tumor diagnosed in our Institute and a positive histology for pancreatic adenocarcinoma...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29026966/the-clinical-implications-of-liver-resection-margin-size-in-patients-with-hepatocellular-carcinoma-in-terms-of-positron-emission-tomography-positivity
#7
Jae Hyun Park, Dong Hwi Kim, Sung Hoon Kim, Moon Young Kim, Soon Koo Baik, In Su Hong
BACKGROUND: The positivity of positron emission tomography (PET) in hepatocellular carcinoma (HCC) correlates with aggressive tumor factors and poor survival. Adequate resection margin size is still a topic of debate. We analyzed the clinical implications of resection margin size in patients with HCC in terms of PET positivity. METHODS: We retrospectively reviewed the medical records of 92 patients who underwent liver resection from March 2012 to October 2015. We investigated prognostic factors for recurrence and survival...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29022283/ex-situ-hepatectomy-and-liver-autotransplantation-for-cholangiocarcinoma
#8
Emilio Vicente, Yolanda Quijano, Benedetto Ielpo, Hipolito Duran, Eduardo Diaz, Isabel Fabra, Luis Malavé, Valentina Ferri, Sara Lazzaro, Denis Kalivaci, Riccardo Caruso
BACKGROUND: Hepatic resection of tumors invading the retrohepatic vena cava and hepatic veins are a challenge for surgeons, who consider them unresectable most of the time.1 (,) 2 Ex situ hepatectomy and liver autotransplantation has developed to improve resectability of these malignancies.3,4 METHODS: The patient was a 51-year-old man who had jaundice secondary to a intrahepatic cholangiocarcinoma 7 cm in diameter in the right lobe of the liver and the caudate lobe. A volumetric scan showed a future liver remnant (segments 2 and 3) not sufficient according to the body weight...
December 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29021421/indication-for-surgical-resection-in-patients-with-hepatocellular-carcinoma-with-major-vascular-invasion
#9
Tokio Higaki, Shintaro Yamazaki, Masamichi Moriguchi, Hisashi Nakayama, Tomoharu Kurokawa, Tadatoshi Takayama
Major portal vein invasion (MVI) by hepatocellular carcinoma (HCC) carries an extremely poor prognosis. Our aim was to clarify the indications of hepatic resection in the presence of MVI by HCC. Between 2001 and 2015, 1,306 patients undergoing primary treatment for HCC were analyzed (866 hepatic resections and 440 transarterial therapies). Significant prognostic factors were identified by retrospectively analyzing tumor status, liver function and treatment. Overall survival was compared in terms of the degree of vascular invasion and treatment...
October 11, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28985853/the-falciform-ligament-as-a-graft-for-portal-superior-mesenteric-vein-reconstruction-in-pancreatectomy
#10
Yang Zhiying, Tan Haidong, Liu Xiaolei, Sun Yongliang, Si Shuang, Liu Liguo, Xu Li, Manar Atyah
BACKGROUND: Tumor invasion or adherence to the portal vein-superior mesenteric vein (PV/SMV) may be encountered during pancreatic surgery. In such cases, venous resection and reconstruction might be required for complete resection of the tumor. We report an innovative technique in which the graft for PV/SMV reconstruction was made with the falciform ligament. METHODS: Between May 2011 and July 2016, PV/SMV reconstruction with a falciform ligament graft was performed in 10 cases during pancreatectomy...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28983654/imaging-and-minimally-invasive-endovascular-therapy-in-the-management-of-portal-vein-thrombosis
#11
Susana G Rodrigues, Martin H Maurer, Iris Baumgartner, Andrea De Gottardi, Annalisa Berzigotti
Thrombosis of the portal venous system, although rare in the general population, is commonly diagnosed in patients with specific underlying conditions including prothrombotic diseases, cirrhosis, hepatobiliary malignancy, and intraabdominal inflammation. Recent improvements in imaging have played a fundamental role in increased detection of portal vein thrombosis (PVT), frequently reported in asymptomatic patients as an incidental finding. Minimally invasive, endovascular therapy is a medically rational option to achieve recanalization of the portal vein as an adjunct to conservative medical management...
October 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28947889/laparoscopic-distal-resection-of-the-pancreas-can-be-all-resections-of-body-and-tail-of-the-pancreas-called-the-same
#12
Audrius Šileikis, Augustas Beiša, Virgilijus Beiša, Mindaugas Kvietkauskas, Marius Kryžauskas, Kęstutis Strupas
INTRODUCTION: Distal resection of the pancreas is a routine procedure in high-volume centres. However, the volume of this procedure can vary. This variation plays a very important role in laparoscopic approach of pancreatic surgery and can be a real challenge if the anatomical situation is underestimated. AIM OF THE STUDY: To present our experience in minimally invasive treatment of the pancreatic tumours and to discuss different approaches to different anatomical situations...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28943929/contrast-enhanced-multiple-phase-imaging-features-of-intrahepatic-mass-forming-cholangiocarcinoma-and-hepatocellular-carcinoma-with-cirrhosis-a-comparative-study
#13
Ying Chen, Yao Pan, Ke-Ren Shen, Xiu-Liang Zhu, Chen-Ying Lu, Qing-Hai Li, Shu-Gao Han, Yan-Biao Fu, Xiu-Fang Xu, Ri-Sheng Yu
The intrahepatic mass-forming cholangiocarcinoma (IMCC) is frequently misdiagnosed as hepatocellular carcinoma (HCC) in patients with cirrhosis, by numerous radiologists and clinical doctors, which results in the incorrect therapeutic treatment. A retrospective case-control study was conducted, and the contrast-enhanced multiple-phase (CEMP) computed tomography (CT) and magnetic resonance imaging (MRI) findings of 22 pathologically confirmed IMCC patients and 22 HCC controls with underlying liver cirrhosis were analyzed at the present hospital, from January 2010 to December 2015...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28937616/sarcopenia-impairs-prognosis-of-patients-with-hepatocellular-carcinoma-the-role-of-liver-functional-reserve-and-tumor-related-factors-in-loss-of-skeletal-muscle-volume
#14
Kenji Imai, Koji Takai, Satoshi Watanabe, Tatsunori Hanai, Atsushi Suetsugu, Makoto Shiraki, Masahito Shimizu
Sarcopenia impairs survival in patients with hepatocellular carcinoma (HCC). This study aimed to clarify the factors that contribute to decreased skeletal muscle volume in patients with HCC. The third lumbar vertebra skeletal muscle index (L3 SMI) in 351 consecutive patients with HCC was calculated to identify sarcopenia. Sarcopenia was defined as an L3 SMI value ≤ 29.0 cm²/m² for women and ≤ 36.0 cm²/m² for men. The factors affecting L3 SMI were analyzed by multiple linear regression analysis and tree-based models...
September 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28927132/downregulation-of-esophageal-cancer-related-gene-4-promotes-proliferation-and-migration-of-hepatocellular-carcinoma
#15
Shujian Ge, Yali Xu, Hongliang Wang, Yaxin Sun, Xiangguo Tian, Zhixin Cao, Xiaoyan Lin, Jiawen Xu, Qiangxiu Wang
Esophageal cancer-related gene 4 (ECRG4) is a candidate tumor suppressor gene, which is involved in cell apoptosis, migration, infection and inflammation responsiveness; however, its expression level and clinical significance in hepatocellular carcinoma (HCC) remains unclear. In the present study, the authors aim to evaluate the clinical significance and potential role of ECRG4 in HCC. Level of ECRG4 protein expression in HCC and peripheral tissues was investigated in tissue specimens obtained from 56 consecutive HCC patients by immunohistochemistry...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28922192/differentiation-of-malignant-thrombus-from-bland-thrombus-of-the-portal-vein-in-patient-with-hepatocellular-carcinoma-on-18f-fdg-pet-ct
#16
Krishan Kant Agarwal, Dipalkumar Shah, Neha Shah, Manas Mayank
Hepatocellular carcinoma carries a high risk of invasion of the portal vein. Neoplastic and bland portal vein thrombi discrimination is of great clinical significance for determining the therapeutic approach, predicting survival, and assessing candidates for liver transplantation. F-FDG PET/CT may be helpful in discriminating between malignant and portal vein thrombi. We present the case of a 61-year old man who presented with hepatocellular carcinoma with portal vein involvement. F-FDG PET/CT has a role in differentiating malignant from benign portal vein thrombosis...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28903105/salvage-hepatectomy-for-recurrent-hepatocellular-carcinoma-after-radiofrequency-ablation-and-or-transcatheter-arterial-chemoembolization-a-propensity-score-matched-analysis
#17
Tatsuya Orimo, Toshiya Kamiyama, Hideki Yokoo, Kenji Wakayama, Shingo Shimada, Takahiro Einama, Hirofumi Kamachi, Akinobu Taketomi
AIM: We aimed to evaluate the short- and long-term surgical outcomes of salvage hepatectomy for recurrent hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) and/or transcatheter arterial chemoembolization (TACE). METHODS: We reviewed the surgical outcomes of 90 recurrent HCC patients after RFA and/or TACE (salvage group) and 490 HCC patients without preoperative treatment (primary group). We performed 1:1 propensity score matching (PSM) between the 2 groups and matched 87 patients in each group...
September 14, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28894793/infiltrative-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-treated-with-a-single-high-dose-y90-radioembolization-and-subsequent-liver-transplantation-without-a-recurrence
#18
Meaghan S Dendy, Juan C Camacho, Johannes M Ludwig, Alyssa M Krasinskas, Stuart J Knechtle, Hyun S Kim
BACKGROUND: Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. METHODS: Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona Clinic Liver Cancer group guidelines, they were enrolled in a prospective open-label radioembolization phase II trial that gave them optimized lobar doses of Yttrium-90 as solely the first-line therapy without concomitant or additional pharmacological or locoregional therapies...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28888777/evaluation-of-hepatocellular-carcinoma-spread-via-the-portal-system-by-3-dimensional-mapping
#19
Shogo Fukutomi, Yoriko Nomura, Osamu Nakashima, Hirohisa Yano, Hiroyuki Tanaka, Yoshito Akagi, Koji Okuda
BACKGROUND/PURPOSE: The pattern of tumor cell spread via the portal system has not been fully clarified in patients with hepatocellular carcinoma (HCC). This study aimed to evaluate the intrahepatic distribution of cancer cells derived from the main tumor by assessing histological portal invasion and/or intrahepatic metastasis (vp/im). METHODS: In 14 patients who underwent anatomical resection of primary solitary HCC ≤ 50 mm in diameter, vp/im were examined pathologically, and the sites of the lesions were reproduced on preoperative 3D-CT images...
September 6, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28881553/-association-between-a-kinase-anchor-proteins-12-methylation-and-recurrence-of-hepatocellular-carcinoma
#20
Z J Liu, W Liu, C H Cui, L K Gu, B C Xing, D J Deng
Objective: To study the association between the AKAP12 promoter methylation and recurrence of hepatocellular carcinoma. Methods: A total of 142 primary liver cancer patients underwent surgery in department of Hepatobiliary surgery in Peking University Cancer Hospital from 2003 to 2009 were selected as subjects in the survey; with the inclusion criteria as hepatocellular carcinoma, no cancer cells were observed in the surgical margin(SM) samples. All patients had neither lymph nor distant metastasis at the time of surgery, and receiving complete follow-up data for at least 3 years...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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