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https://www.readbyqxmd.com/read/29914246/role-of-hepcidin-in-the-diagnosis-of-sepsis-and-septic-shock-in-children
#1
Osman Yeşilbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kıhtır, Asuman Gedikbaşı, Mey Talip Petmezci, Canan Baydemir
Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29908849/cephalic-region-war-injuries-in-children-experience-in-french-nato-hospital-in-kabul-afghanistan
#2
Hussam El Chehab, Emilie Agard, Corinne Dot
BACKGROUNDS: The NATO KAIA Hospital (Kabul International Airport), under French command, provided medical support for NATO forces in the Kabul region from 2009 to 2014. Medical assistance to civilians was an additional mission which included support for children who were war injured. The objective of this study was to analyze characteristics of cephalic injuries in children victims of war trauma. METHODS: A retrospective study was conducted and commenced with the hospital opening (July 2009) to March 2012 on all children (<15years) with war trauma...
June 9, 2018: Injury
https://www.readbyqxmd.com/read/29902516/establishment-of-a-species-specific-primer-pair-for-detecting-veillonella-infantium-based-on-the-70-kda-heat-shock-protein-gene-dnak
#3
Izumi Mashima, Ariadna A Djais, Elaine M Haase, Frank A Scannapieco, Maiko Otomo, Masato Saitoh, Futoshi Nakazawa
Recently, Veillonella infantium was isolated from tongue biofilm of a Thai child and established as a novel Veillonella species. In this study, a species-specific primer was designed to identify V. infantium on the basis of the sequence of the 70 kDa heat shock protein (dnaK) gene of Veillonella infantium JCM 31738T (= TSD-88T ). The primer pair generated a specific PCR (Polymerase Chain Reaction) product specific for V. infantium, but not for other oral Veillonella species. This specific primer pair could detect dnaK even from 1 pg of genomic DNA extracted from the V...
June 11, 2018: Anaerobe
https://www.readbyqxmd.com/read/29893360/extracorporeal-cardiopulmonary-resuscitation-in-children-of-asia-pacific-a-retrospective-analysis-of-extracorporeal-life-support-organization-registry
#4
Gai-Ling Chen, Ye-Ru Qiao, Jin-Hui Ma, Jian-Xin Wang, Fei-Long Hei, Jie Yu
Background: Recent advances in extracorporeal membrane oxygenation (ECMO) have led to increasing interest in its use during cardiopulmonary resuscitation (CPR). However, decisions regarding extracorporeal CPR (ECPR) in children are difficult as a result of limited studies, especially in Asia Pacific. The objective of this study was to investigate trends in survival and demographic details for children with ECPR in Asia Pacific recorded in the Extracorporeal Life Support Organization (ELSO) registry from 1999 to 2016 and identify the risk factors associated with in-hospital mortality...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29891404/influenza-associated-neurological-complications-during-2014-2017-in-taiwan
#5
Li-Wen Chen, Chao-Ku Teng, Yi-Shan Tsai, Jieh-Neng Wang, Yi-Fang Tu, Ching-Fen Shen, Ching-Chuan Liu
INTRODUCTION: Seasonal influenza-associated neurological complications had high mortality and morbidity rates in recent studies. We reported influenza-associated encephalitis/encephalopathy in children during 2014-2017 in Taiwan, focusing on neurological presentations, neuroimaging correlations, and critical care managements. MATERIALS/SUBJECTS: During January 1st 2014 to June 30th 2017, pediatric patients reported to the Taiwan Centers for Disease Control surveillance system for severe complicated influenza infections in the hospital were retrospectively reviewed...
June 8, 2018: Brain & Development
https://www.readbyqxmd.com/read/29888440/kawasaki-disease-shock-syndrome-a-unique-and-severe-subtype-of-kawasaki-disease
#6
Luisa Berenise Gamez-Gonzalez, Isabel Moribe-Quintero, Martin Cisneros-Castolo, Javier Varela-Ortiz, Mireya Muñoz-Ramírez, Martin Garrido-García, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease shock syndrome (KDSS) is an uncommon presentation of Kawasaki disease (KD). KDSS has been associated with more severe markers of inflammation, coronary abnormalities and IVIG resistance. METHODS: A retrospective, descriptive study of children with KDSS in two hospitals was performed. Relevant articles about KD and shock were collected, demographic data, clinical presentation, laboratory variables, echocardiogram findings, treatment and special features were analyzed when available...
June 11, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29886891/-gastric-perforation-in-a-two-year-old-girl
#7
Vinni Faber Rasmussen, Iben Møller Jønsson, Henriette Lassen Schaumburg
Gastric perforation is a life-threatening condition and is rarely seen in children. In this case report a two-year-old girl with a two-day history of fever and severe abdominal pain was evaluated in an emergency department. When she was four months old, she had surgery for malrotation. On examination the abdomen was distended, and her condition deteriorated rapidly with signs of shock. A computerised axial tomography scan revealed pneumoperitoneum, and intraoperative findings proved gastric perforation. Surgery was successful...
June 11, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29885825/long-term-single-center-experience-of-defibrillator-therapy-in-children-and-adolescents
#8
Gerrit Frommeyer, Sebastian Feder, Markus Bettin, Volker Debus, Julia Köbe, Florian Reinke, Anselm Uebing, Lars Eckardt, Hans Gerd Kehl
BACKGROUND: Implantable cardioverter-defibrillator (ICD) systems are established therapy for prevention of sudden cardiac death. Long-term data on ICD systems in children and adolescents is rare. The present study displays a long-term single-center follow-up of children and adolescents with ICD systems. METHODS AND RESULTS: The present study represents a single-center experience of patients younger than 18 years who received an ICD (n = 58). Follow-up data included in-house follow-up as well as examinations of collaborating specialists...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29859007/medical-and-surgical-interventions-for-the-treatment-of-urinary-stones-in-children
#9
REVIEW
Lenka Barreto, Jae Hung Jung, Ameera Abdelrahim, Munir Ahmed, Guy P C Dawkins, Marcin Kazmierski
BACKGROUND: Urolithiasis is a condition where crystalline mineral deposits (stones) form within the urinary tract. Urinary stones can be located in any part of the urinary tract. Affected children may present with abdominal pain, blood in the urine or signs of infection. Radiological evaluation is used to confirm the diagnosis, to assess the size of the stone, its location, and the degree of possible urinary obstruction. OBJECTIVES: To assess the effects of different medical and surgical interventions in the treatment of urinary tract stones of the kidney or ureter in children...
June 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29808278/clinical-and-laboratory-predictors-of-blood-loss-in-young-swine-a-model-for-pediatric-hemorrhage
#10
Xiaoming Shi, Mary J Edwards, Jordan Guice, Richard Strilka, Brandon Propper
BACKGROUND: The pediatric patient's response to hemorrhage as a function of young age is not well understood. As a result, there is no consensus on optimal resuscitation strategies for hemorrhagic shock in pediatric patients, or on the identification of clinical triggers to prompt implementation. The study objective was to develop a model of pediatric hemorrhage using young pigs to simulate school-aged children, and determine clinical and laboratory indicators for significant hemorrhage...
May 28, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29799085/venoarterial-extracorporeal-membrane-oxygenation-support-for-neonatal-and-pediatric-refractory-septic-shock-more-than-15-years-of-learning
#11
Anna Solé, Iolanda Jordan, Sara Bobillo, Julio Moreno, Monica Balaguer, Lluisa Hernández-Platero, Susana Segura, Francisco José Cambra, Elisabeth Esteban, Javier Rodríguez-Fanjul
The objective of the study was to report our institutional experience in the management of children and newborns with refractory septic shock who required venoarterial extracorporeal membrane oxygenation (VA ECMO) treatment, and to identify patient-and infection-related factors associated with mortality. This is a retrospective case series in an intensive care unit of a tertiary pediatric center. Inclusion criteria were patients ≤ 18 years old who underwent a VA ECMO due to a refractory septic shock due to circulatory collapse...
May 24, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29784051/contributions-of-a-survey-and-retrospective-cohort-study-to-the-planning-of-a-randomised-controlled-trial-of-corticosteroids-in-the-treatment-of-paediatric-septic-shock
#12
Anna Liu, Kusum Menon
BACKGROUND: Randomised controlled trials (RCTs) are challenging to conduct in a paediatric critical-care environment. Background work, including surveys and observational studies, is often used to determine disease estimates, sample sizes and design protocols when planning such RCTs. Our objective was to determine the necessity of performing a survey or a retrospective chart review or both when planning an RCT on corticosteroids in the treatment of paediatric septic shock. METHODS: We compared information on corticosteroid use for moderate to severe paediatric septic shock obtained from a survey of physician beliefs and stated practices with that obtained from a retrospective cohort study...
May 21, 2018: Trials
https://www.readbyqxmd.com/read/29783819/-value-of-urine-soluble-triggering-receptor-expressed-on-myeloid-cells-1-in-the-early-diagnosis-of-sepsis-associated-acute-kidney-injury
#13
Z K Yuan, F Fang, C J Liu, J Li, Y F Chen, F Xu
Objective: To assess the value of urine soluble triggering receptor expressed on myeloid cells-1(sTREM-1) in early diagnosis and prognosis of sepsis associated acute kidney injury (AKI). Methods: This was a case-control study. A total of 62 patients with sepsis during November 2016 to June 2017 were collected, who were divided into non-AKI sepsis ( n= 49) and AKI sepsis ( n= 13) groups according to the serum creatinine (SCr) or urine output, sepsis with shock ( n= 22) and sepsis without shock ( n= 40) groups according to the presence of shock, survival ( n= 47) and death ( n= 15) groups according to the mortality...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29782390/suspecting-hyperferritinemic-sepsis-in-iron-deficient-population-do-we-need-a-lower-plasma-ferritin-threshold
#14
Swarup Ghosh, Arun K Baranwal, Prateek Bhatia, Karthi Nallasamy
OBJECTIVES: Hyperferritinemia is being suggested to identify patients with sepsis-induced macrophage activation syndrome for early intervention. However, data among iron-deficient children are scarce. This study was planned to explore the biological behavior of plasma ferritin in children from communities with a high frequency of iron deficiency with septic shock and its association with the outcome. DESIGN: Prospective observational study. SETTING: Tertiary care teaching hospital in a low-middle income economy of South Asia...
May 18, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29768710/improving-the-safety-of-high-dose-methotrexate-for-children-with-hematologic-cancers-in-settings-without-access-to-mtx-levels-using-extended-hydration-and-additional-leucovorin
#15
Kalthi Vaishnavi, Deepak Bansal, Amita Trehan, Richa Jain, Savita Verma Attri
BACKGROUND: A lack of access to methotrexate levels is common in low- and middle-income countries (LMIC), relevant for 80% of children with cancer worldwide. We evaluated whether high-dose methotrexate (HD-MTX) can be administered safely with extended hydration and leucovorin rescue, with monitoring of serum creatinine and urine pH. METHODS: The prospective study was conducted at a single centre in Chandigarh, India in 2015. Patients with B-cell acute lymphoblastic leukemia (ALL) or with T-cell ALL or non-Hodgkin lymphoma (T-NHL) were administered 3 and 5 gm/m2 of MTX (24 hr infusion), respectively...
May 16, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29768296/pediatric-diabetic-ketoacidosis-with-hypotensive-shock-and-rash-an-unusual-presentation
#16
Yehonatan Pasternak, Omer Niv, Yehezkel Hezi Waisman
We describe a previously healthy adolescent boy who presented with respiratory distress, hypotensive shock, and a diffuse erythematous rash. The final diagnosis was diabetic ketoacidosis. Caregivers should be alert to this unusual combination of symptoms in the emergency department setting in order to improve the recognition and management of children with new-onset diabetes.
May 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29761418/growing-and-learning-when-consumption-is-seasonal-long-term-evidence-from-tanzania
#17
Paul Christian, Brian Dillon
This article shows that the seasonality of food consumption during childhood, conditional on average consumption, affects long-run human capital development. We develop a model that distinguishes differences in average consumption levels, seasonal fluctuations, and idiosyncratic shocks, and estimate the model using panel data from early 1990s Tanzania. We then test whether the mean and seasonality of a child's consumption profile affect height and educational attainment in 2010. Results show that the negative effects of greater seasonality are 30 % to 60 % of the magnitudes of the positive effects of greater average consumption...
May 14, 2018: Demography
https://www.readbyqxmd.com/read/29756704/cerebrospinal-fluid-shunt-associated-infections-in-pediatrics-analysis-of-the-epidemiology-and-mortality-risk-factors
#18
Soledad González, Mirta Carbonaro, Ana G Fedullo, María I Sormani, María Del C Ceinos, Roberto González, María T Rosanova
INTRODUCTION: Infections are the most common complications of ventricular cerebrospinal fluid shunts. The objective of this study was to describe the clinical, microbiological, and evolutionary characteristics of children with ventricular cerebrospinal fluid shunt-associated infections and analyze the risk factors for mortality. POPULATION AND METHODS: Descriptive, retrospective study carried out at Hospital "Prof. Dr. Juan P. Garrahan" in the Autonomous City of Buenos Aires...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29750654/initial-presentations-and-associated-clinical-findings-in-patients-with-classical-congenital-adrenal-hyperplasia
#19
Asmaa Adel Milyani, Abdulmoein Eid Al-Agha, Mashael Al-Zanbagi
BACKGROUND: The objective of this study was to investigate the initial presenting features of children with classical congenital adrenal hyperplasia (CAH). METHODS: This is a descriptive retrospective study over a period of 5 years. Data analysis was performed using Statistical Package for Social Science. RESULTS: Ambiguous genitalia (AG) was the commonest initial presentation marking 50.7% of the patients. On the other hand, 33.3% presented with a salt-losing crisis, 4...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29748799/metal-contamination-in-quail-meat-residues-sources-molecular-biomarkers-and-human-health-risk-assessment
#20
Wageh Sobhy Darwish, Amira Samir Atia, Mariam H E Khedr, Walaa Fathy Saad Eldin
Quail meat is an emerging source of high-quality animal protein. Quails are exposed to a wide range of xenobiotics such as heavy metals. In this study, residual concentrations of four toxic metals, of significant public health importance, including cadmium (Cd), lead (Pb), arsenic (As), and nickel (Ni), were determined in edible tissues of quails. In addition, metal loads were measured in water, feed, and litter samples collected from same quail farms as possible sources for quail exposure to heavy metals. The possible use of metallothionein (MT) and heat shock protein 70 (Hsp70) as molecular biomarkers of exposure to heavy metals was further investigated...
May 10, 2018: Environmental Science and Pollution Research International
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