Filippo Martinelli, Almut Heinken, Ann-Kristin Henning, Maria A Ulmer, Tim Hensen, Antonio González, Matthias Arnold, Sanjay Asthana, Kathrin Budde, Corinne D Engelman, Mehrbod Estaki, Hans-Jörgen Grabe, Margo B Heston, Sterling Johnson, Gabi Kastenmüller, Cameron Martino, Daniel McDonald, Federico E Rey, Ingo Kilimann, Olive Peters, Xiao Wang, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Matthias Nauck, Stefan Teipel, Rob Knight, Rima F Kaddurah-Daouk, Barbara B Bendlin, Johannes Hertel, Ines Thiele
In this study, we aimed to understand the potential role of the gut microbiome in the development of Alzheimer's disease (AD). We took a multi-faceted approach to investigate this relationship. Urine metabolomics were examined in individuals with AD and controls, revealing decreased formate and fumarate concentrations in AD. Additionally, we utilised whole-genome sequencing (WGS) data obtained from a separate group of individuals with AD and controls. This information allowed us to create and investigate host-microbiome personalised whole-body metabolic models...
March 13, 2024: Scientific Reports