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https://www.readbyqxmd.com/read/29663511/extra-hepatic-cancers-are-the-leading-cause-of-death-in-cirrhotic-patients-achieving-hbv-control-or-hcv-eradication
#1
Manon Allaire, Pierre Nahon, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino, Angela Sutton, Eric Letouzé, Etienne Audureau, Françoise Roudot-Thoraval
BACKGROUND: Data on extrahepatic cancers (EHC) in compensated viral cirrhosis are limited. The objective of the prospective multicenter ANRS CO12 CirVir cohort was to assess the occurrence of all clinical events in patients with compensated viral cirrhosis, including all types of cancer. METHODS: Patients with the following inclusion criteria were enrolled in 35 French centers: a) biopsy-proven HBV or HCV cirrhosis; b) Child-Pugh A; c) absence of previous liver complications including primary liver cancer (PLC)...
April 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29660688/implementation-and-validation-of-an-improved-allele-specific-stutter-filtering-method-for-electropherogram-interpretation
#2
Tim Kalafut, Curt Schuerman, Joel Sutton, Tom Faris, Luigi Armogida, Jo-Anne Bright, John Buckleton, Duncan Taylor
Modern probabilistic genotyping (PG) software is capable of modeling stutter as part of the profile weighting statistic. This allows for peaks in stutter positions to be considered as allelic or stutter or both. However, prior to running any sample through a PG calculator, the examiner must first interpret the sample, considering such things as artifacts and number of contributors (NOC or N). Stutter can play a major role both during the assignment of the number of contributors, and the assessment of inclusion and exclusion...
March 31, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29659958/food-photography-is-not-an-accurate-measure-of-energy-intake-in-obese-pregnant-women
#3
Jasper Most, Porsha M Vallo, Abby D Altazan, Linda Anne Gilmore, Elizabeth F Sutton, Loren E Cain, Jeffrey H Burton, Corby K Martin, Leanne M Redman
Background: To improve weight management in pregnant women, there is a need to deliver specific, data-based recommendations on energy intake. Objective: This cross-sectional study evaluated the accuracy of an electronic reporting method to measure daily energy intake in pregnant women compared with total daily energy expenditure (TDEE). Methods: Twenty-three obese [mean ± SEM body mass index (kg/m2): 36.9 ± 1.3] pregnant women (aged 28...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659093/oral-intake-evaluation-in-patients-following-critical-illness-an-icu-cohort-study
#4
Rebecca J Jarden, Lynsey Sutton-Smith, Catherine Boulton
Timely and adequate nutrition improves health outcomes for the critically ill patient. Despite clinical guidelines recommending early oral nutrition, survivors of critical illness experience significant nutritional deficits. This cohort study evaluates the oral nutrition intake in intensive care unit (ICU) patients who have experienced recent critical illness. The oral nutrition intake of a convenience sample of ICU patients post-critical illness was observed during a 1-month period. Data pertaining to both the amount of oral nutrition intake and factors impacting optimal oral nutrition intake were collected and analysed...
April 16, 2018: Nursing in Critical Care
https://www.readbyqxmd.com/read/29656860/truncating-variants-in-naa15-are-associated-with-variable-levels-of-intellectual-disability-autism-spectrum-disorder-and-congenital-anomalies
#5
Hanyin Cheng, Avinash V Dharmadhikari, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E Posey, Sarah R Crews, Mohammad K Eldomery, Zeynep Coban Akdemir, Andrea M Lewis, Vernon R Sutton, Jill A Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A High, Marjon A van Slegtenhorst, Grazia M S Mancini, Candice R Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S Beighley, Raphael A Bernier, Sébastien Küry, Mathilde Nizon, Mark A Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J Jongmans, Bert B A de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K Rojas, Kym M Boycott, Richard Person, Rebecca Willaert, Evan E Eichler, R Frank Kooy, Yaping Yang, Joseph C Wu, James R Lupski, Thomas Arnesen, Gregory M Cooper, Wendy K Chung, Jozef Gecz, Holly A F Stessman, Linyan Meng, Gholson J Lyon
N-alpha-acetylation is a common co-translational protein modification that is essential for normal cell function in humans. We previously identified the genetic basis of an X-linked infantile lethal Mendelian disorder involving a c.109T>C (p.Ser37Pro) missense variant in NAA10, which encodes the catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. The auxiliary subunit of the NatA complex, NAA15, is the dimeric binding partner for NAA10. Through a genotype-first approach with whole-exome or genome sequencing (WES/WGS) and targeted sequencing analysis, we identified and phenotypically characterized 38 individuals from 33 unrelated families with 25 different de novo or inherited, dominantly acting likely gene disrupting (LGD) variants in NAA15...
April 9, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29651778/cost-consequence-analysis-alongside-a-randomised-controlled-trial-of-hospital-versus-telephone-follow-up-after-treatment-for-endometrial-cancer
#6
Padraig Dixon, Kinta Beaver, Susan Williamson, Chris Sutton, Pierre Martin-Hirsch, William Hollingworth
BACKGROUND: Regular outpatient follow-up programmes are usually offered to patients following treatment for gynaecological and other cancers. Despite the substantial resources involved in providing these programmes, there is evidence that routine follow-up programmes do not affect survival or the likelihood of detecting recurrence and may not meet patient needs. Alternative follow-up modalities may offer the same outcomes at lower cost. We examined the costs of using telephone-based routine follow-up of women treated for endometrial cancer undertaken by specialist gynaecology oncology nurses in comparison to routine hospital-based follow-up...
April 12, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29651524/natural-deep-eutectic-solvents-as-the-major-mobile-phase-components-in-high-performance-liquid-chromatography-searching-for-alternatives-to-organic-solvents
#7
Adam T Sutton, Karina Fraige, Gabriel Mazzi Leme, Vanderlan da Silva Bolzani, Emily F Hilder, Alberto J Cavalheiro, R Dario Arrua, Cristiano Soleo Funari
Over the past six decades, acetonitrile (ACN) has been the most employed organic modifier in reversed-phase high-performance liquid chromatography (RP-HPLC), followed by methanol (MeOH). However, from the growing environmental awareness that leads to the emergence of "green analytical chemistry," new research has emerged that includes finding replacements to problematic ACN because of its low sustainability. Deep eutectic solvents (DES) can be produced from an almost infinite possible combinations of compounds, while being a "greener" alternative to organic solvents in HPLC, especially those prepared from natural compounds called natural DES (NADES)...
April 12, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29651059/aesthetic-possibilities-in-removable-prosthodontics-part-3-photometric-tooth-selection-tooth-setting-try-in-fitting-reviewing-and-trouble-shooting
#8
J N Besford, A F Sutton
This final article in a series of three on producing complete dentures which the patient considers attractive, describes selecting the denture teeth, setting the front teeth at the chairside, the try-in visits, processing, fitting and reviewing the dentures. The role of the patient as captain of the ship, the dental nurse as the patient's support and liaison officer, and the clinician as the first technical officer is outlined. The use of immediate replay video technology in allowing a patient to see what the trial denture really looks like is described...
April 13, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29644944/a-new-heligmonellid-nematoda-species-of-the-genus-stilestrongylus-in-euryoryzomys-russatus-rodentia-sigmodontinae-in-the-atlantic-forest-southern-brazil
#9
R G Boullosa, R O Simões, B E Andrade-Silva, R Gentile, A Maldonado
A new species of Nippostrongylinae (Nematoda: Heligmonellidae), Stilestrongylus rolandoi n. sp., is described from specimens collected from the small intestine of the rodent Euryoryzomys russatus in the Atlantic Forest (Santo Amaro da Imperatriz, Santa Catarina state, southern Brazil). The genus Stilestrongylus includes 23 species, which parasitize rodents occurring in the Neotropical region. Stilestrongylus aureus (Durette-Desset & Sutton, 1985) from Argentina, S. azarai (Durette-Desset & Sutton, 1985) from Argentina, S...
April 12, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29629927/physiology-directed-cardiopulmonary-resuscitation-advances-in-precision-monitoring-during-cardiac-arrest
#10
Alexandra M Marquez, Ryan W Morgan, Catherine E Ross, Robert A Berg, Robert M Sutton
PURPOSE OF REVIEW: We review the recent advances in physiologic monitoring during cardiac arrest and offer an evidence-based framework for prioritizing physiologic targets during cardiopulmonary resuscitation (CPR). RECENT FINDINGS: Current CPR guidelines recommend a uniform approach for all patients in cardiac arrest, but newer data support a precision strategy that uses the individual patient's physiology to guide resuscitation. Coronary perfusion pressure and arterial DBP are associated with survival outcomes in recent animal and human studies...
April 6, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29627966/spatiotemporal-heterogeneity-and-patterning-of-developing-renal-blood-vessels
#11
Edward Daniel, D Berfin Azizoglu, Anne R Ryan, Tezin A Walji, Christopher P Chaney, Gabrielle I Sutton, Thomas J Carroll, Denise K Marciano, Ondine Cleaver
The kidney vasculature facilitates the excretion of wastes, the dissemination of hormones, and the regulation of blood chemistry. To carry out these diverse functions, the vasculature is regionalized within the kidney and along the nephron. However, when and how endothelial regionalization occurs remains unknown. Here, we examine the developing kidney vasculature to assess its 3-dimensional structure and transcriptional heterogeneity. First, we observe that endothelial cells (ECs) grow coordinately with the kidney bud as early as E10...
April 7, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29627925/spirituality-in-african-american-breast-cancer-patients-implications-for-clinical-and-psychosocial-care
#12
Vanessa B Sheppard, Robin Walker, Winifred Phillips, Victoria Hudson, Hanfei Xu, Mark L Cabling, Jun He, Arnethea L Sutton, Jill Hamilton
Spirituality has been shown to be important to many individuals dealing with a cancer diagnosis. While African-American breast cancer survivors have been reported to have higher levels of spirituality compared to White women, little is known about how levels of spirituality may vary among African-American breast cancer survivors. The aims of this study were to examine factors associated with spirituality among African-American survivors and test whether spirituality levels were associated with women's attitudes about treatment or health care...
April 7, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29627744/a-robust-and-versatile-mass-spectrometry-platform-for-comprehensive-assessment-of-the-thiol-redox-metabolome
#13
T R Sutton, M Minnion, F Barbarino, G Koster, B O Fernandez, A F Cumpstey, P Wischmann, M Madhani, M P Frenneaux, A D Postle, M M Cortese-Krott, M Feelisch
Several diseases are associated with perturbations in redox signaling and aberrant hydrogen sulfide metabolism, and numerous analytical methods exist for the measurement of the sulfur-containing species affected. However, uncertainty remains about their concentrations and speciation in cells/biofluids, perhaps in part due to differences in sample processing and detection principles. Using ultrahigh-performance liquid chromatography in combination with electrospray-ionization tandem mass spectrometry we here outline a specific and sensitive platform for the simultaneous measurement of 12 analytes, including total and free thiols, their disulfides and sulfide in complex biological matrices such as blood, saliva and urine...
February 19, 2018: Redox Biology
https://www.readbyqxmd.com/read/29627231/status-of-vaccine-research-and-development-for-helicobacter-pylori
#14
Philip Sutton, Joanne M Boag
Gastric adenocarcinoma is globally the third leading cause of death due to malignancy, with the bulk of this disease burden being suffered by low and middle income countries (LMIC), especially in Asia. The majority of these cancers develop as a result of a chronic gastritis that arises in response to infection with the stomach-dwelling bacterium, Helicobacter pylori. A vaccine against this pathogen would therefore be a powerful tool for preventing gastric adenocarcinoma. However, notwithstanding a proof-of-concept that vaccination can protect children from acquisition of H...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29626097/oxidative-stress-alters-mitochondrial-bioenergetics-and-modifies-pancreatic-cell-death-independently-of-cyclophilin-d-resulting-in-an-apoptosis-to-necrosis-shift
#15
Jane A Armstrong, Nicole J Cash, Yulin Ouyang, Jack C Morton, Michael Chvanov, Diane Latawiec, Muhammad Awais, Alexei V Tepikin, Robert Sutton, David N Criddle
Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca2+ -dependent formation of the mitochondrial permeability transition pore (MPTP), a solute channel modulated by cyclophilin D (CypD), whose formation causes ATP depletion and necrosis. Oxidative stress reportedly triggers MPTP formation and is elevated in clinical AP, but how reactive oxygen species influence cell death is unclear. Here, we assessed potential MPTP involvement in oxidant-induced effects on pancreatic acinar cell bioenergetics and fate...
April 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29622045/a-couple-based-hiv-prevention-intervention-for-latino-men-who-have-sex-with-men-study-protocol-for-a-randomized-controlled-trial
#16
Omar Martinez, M Isabel Fernandez, Elwin Wu, Alex Carballo-Diéguez, Guillermo Prado, Adam Davey, Ethan Levine, Brian Mattera, Nikki Lopez, Omar Valentin, Ashley Murray, Madeline Sutton
BACKGROUND: Latino men who have sex with men (MSM) experienced a 13% increase in HIV diagnoses from 2010 to 2014, more than any other racial/ethnic subgroup of MSM in the United States. If current HIV diagnoses rates persist, about one in four Latino MSM in the United States will be diagnosed with HIV during their lifetime. Although some efficacious HIV prevention interventions for Latino MSM exist, none have focused on couples. This paper describes the protocol of a randomized controlled trial (RCT) to test the preliminary efficacy of a couple-based HIV prevention intervention that is culturally tailored for Latino men and their same-sex partners...
April 5, 2018: Trials
https://www.readbyqxmd.com/read/29620945/influence-of-depressive-symptoms-on-hallux-valgus-surgical-outcomes
#17
Rachel Shakked, Elizabeth McDonald, Ryan Sutton, Mary-Katherine Lynch, Kristen Nicholson, Steven Raikin
BACKGROUND: The relationship between depressive symptoms and patient outcomes after hallux valgus surgery has not been well-studied. We hypothesized that patients with depressive symptoms would have greater subjective dysfunction preoperatively and less functional improvement and satisfaction after surgery when compared with patients without depressive symptoms. METHODS: A total of 239 adult patients who had surgical hallux valgus correction over a 2-year period were retrospectively enrolled...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29620604/diffusion-weighted-imaging-with-apparent-diffusion-coefficient-mapping-for-breast-cancer-detection-as-a-stand-alone-parameter-comparison-with-dynamic-contrast-enhanced-and-multiparametric-magnetic-resonance-imaging
#18
Katja Pinker, Linda Moy, Elizabeth J Sutton, Ritse M Mann, Michael Weber, Sunitha B Thakur, Maxine S Jochelson, Zsuzsanna Bago-Horvath, Elizabeth A Morris, Pascal At Baltzer, Thomas H Helbich
PURPOSE: The aims of this study were to compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) with apparent diffusion coefficient mapping as a stand-alone parameter without any other supportive sequence for breast cancer detection and to assess its combination as multiparametric MRI (mpMRI) of the breast. MATERIALS AND METHODS: In this institutional review board-approved single-center study, prospectively acquired data of 106 patients who underwent breast MRI from 12/2010 to 09/2014 for an imaging abnormality (Breast Imaging Reporting and Data System 0, 4/5) were retrospectively analyzed...
April 3, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29615134/improving-outcomes-after-pediatric-cardiac-arrest-the-icu-resuscitation-project-study-protocol-for-a-randomized-controlled-trial
#19
Ron W Reeder, Alan Girling, Heather Wolfe, Richard Holubkov, Robert A Berg, Maryam Y Naim, Kathleen L Meert, Bradley Tilford, Joseph A Carcillo, Melinda Hamilton, Matthew Bochkoris, Mark Hall, Tensing Maa, Andrew R Yates, Anil Sapru, Robert Kelly, Myke Federman, J Michael Dean, Patrick S McQuillen, Deborah Franzon, Murray M Pollack, Ashley Siems, John Diddle, David L Wessel, Peter M Mourani, Carleen Zebuhr, Robert Bishop, Stuart Friess, Candice Burns, Shirley Viteri, David A Hehir, R Whitney Coleman, Tammara L Jenkins, Daniel A Notterman, Robert F Tamburro, Robert M Sutton
BACKGROUND: Quality of cardiopulmonary resuscitation (CPR) is associated with survival, but recommended guidelines are often not met, and less than half the children with an in-hospital arrest will survive to discharge. A single-center before-and-after study demonstrated that outcomes may be improved with a novel training program in which all pediatric intensive care unit staff are encouraged to participate in frequent CPR refresher training and regular, structured resuscitation debriefings focused on patient-centric physiology...
April 3, 2018: Trials
https://www.readbyqxmd.com/read/29614247/pseudomonas-aeruginosa-adapts-to-octenidine-in-the-laboratory-and-a-simulated-clinical-setting-leading-to-increased-tolerance-to-chlorhexidine-and-other-biocides
#20
Matthew J Shepherd, Ginny Moore, Matthew E Wand, J Mark Sutton, Lucy J Bock
BACKGROUND: Octenidine is frequently used for infection prevention in neonatal and burn intensive care units, where Pseudomonas aeruginosa has caused nosocomial outbreaks. AIM: To investigate the efficacy and impact of using octenidine against P. aeruginosa. METHODS: Seven clinical isolates of P. aeruginosa were exposed to increasing concentrations of octenidine over several days. Fitness, minimum bactericidal concentrations after 1 minute, 5 minutes and 24 hours, and minimum inhibitory concentrations of a variety of antimicrobials were measured for the parental and octenidine-adapted P...
March 31, 2018: Journal of Hospital Infection
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