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Early Warning System

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https://www.readbyqxmd.com/read/28934690/butyl-benzyl-phthalate-bbp-induces-caudal-defects-during-embryonic-development
#1
Nicole M Roy, Ewelina Zambrzycka, Jenna Santangelo
Butyl benzyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity. However, BBP leaches off of plastic and environment presence has been detected in soil, groundwater and sediment potentially effecting organisms in the environment. Given the widespread uses of BBP in household, consumer goods and the presence of BBP in the environment, studies on developmental toxicity are needed. Here, we use a zebrafish model to investigate the early developmental toxicity of BBP...
September 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28928156/clinician-perceptions-of-an-early-warning-system-on-patient-safety
#2
Aisha de Vries, Jos M T Draaisma, Joris Fuijkschot
BACKGROUND AND OBJECTIVES: The Pediatric Early Warning Score (PEWS) aims to improve early recognition of clinical deterioration and is widely used despite lacking evidence of effects on outcome measures such as hospital mortality. In this qualitative study, we aimed to study effects of both PEWS and the locally designed risk stratification system by focusing on professionals' perception of their performance. We also sought to gain insight into the perceived effects of PEWS and the risk stratification system on patient safety and to unravel the underlying mechanisms...
September 19, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28918932/building-and-verifying-a-severity-prediction-model-of-acute-pancreatitis-ap-based-on-bisap-mews-and-routine-test-indexes
#3
Jiang-Feng Ye, Yu-Xin Zhao, Jian Ju, Wei Wang
PURPOSE: To discuss the value of the Bedside Index for Severity in Acute Pancreatitis (BISAP), Modified Early Warning Score (MEWS), serum Ca2+, similarly hereinafter, and red cell distribution width (RDW) for predicting the severity grade of acute pancreatitis and to develop and verify a more accurate scoring system to predict the severity of AP. METHODS: In 302 patients with AP, we calculated BISAP and MEWS scores and conducted regression analyses on the relationships of BISAP scoring, RDW, MEWS, and serum Ca2+ with the severity of AP using single-factor logistics...
September 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28915258/rapid-emergency-medicine-score-a-novel-prognostic-tool-for-predicting-the-outcomes-of-adult-patients-with-hepatic-portal-venous-gas-in-the-emergency-department
#4
Chen-June Seak, David Hung-Tsang Yen, Chip-Jin Ng, Yon-Cheong Wong, Kuang-Hung Hsu, Joanna Chen-Yeen Seak, Hsien-Yi Chen, Chen-Ken Seak
OBJECTIVE: This study aims to evaluate the performance of Rapid Emergency Medicine Score (REMS), Rapid Acute Physiology Score (RAPS), and Modified Early Warning Score (MEWS) in ascertaining the severity of illness and predicting the mortality of adult hepatic portal venous gas (HPVG) patients presenting to the emergency department (ED). This will assist emergency physicians (EPs) in risk stratification. METHODS: Data for 66 adult HPVG patients who visited the EDs of 2 research hospitals between October 1999 and April 2016 were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28891787/biochemical-approaches-to-assess-oxidative-stress-induced-by-exposure-to-natural-and-synthetic-dyes-in-early-life-stages-in-zebrafish
#5
Flavia R Abe, Carlos Gravato, Amadeu M V M Soares, Danielle P de Oliveira
Zebrafish early life stages were found to be sensitive to several synthetic dyes widely used in industries. However, as environmental concentrations of such contaminants are often at sublethal levels, more sensitive methods are required to determine early-warning adverse consequences. The aim of this study was to utilize a multibiomarker approach to examine underlying oxidative stress mechanisms triggered by sublethal concentrations of synthetic azo dye Basic Red 51 (BR51), the natural dye erythrostominone (ERY), and its light-degraded product using zebrafish embryos...
September 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28888429/taste-receptors-in-the-gut-a-new-target-for-health-promoting-properties-in-diet
#6
REVIEW
Bo Ekstrand, Jette Feveile Young, Martin Krøyer Rasmussen
In this review we describe a new target for food functionality, the taste receptors in the gastrointestinal tract. These receptors are involved in an intricate signalling network for monitoring of taste and nutrient intake, homeostasis and energy metabolism, and they are also an early warning system for toxic substances in our diet. Especially the receptors for bitter taste provide a new possibility to activate a number of health related signalling pathways, already at low concentrations of the active substance, without requiring uptake into the body and transport via the circulation...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28881451/validation-of-a-pediatric-early-warning-system-for-hospitalized-pediatric-oncology-patients-in-a-resource-limited-setting
#7
Asya Agulnik, Alejandra Méndez Aceituno, Lupe Nataly Mora Robles, Peter W Forbes, Dora Judith Soberanis Vasquez, Ricardo Mack, Federico Antillon-Klussmann, Monica Kleinman, Carlos Rodriguez-Galindo
BACKGROUND: Pediatric oncology patients are at high risk of clinical deterioration, particularly in hospitals with resource limitations. The performance of pediatric early warning systems (PEWS) to identify deterioration has not been assessed in these settings. This study evaluates the validity of PEWS to predict the need for unplanned transfer to the pediatric intensive care unit (PICU) among pediatric oncology patients in a resource-limited hospital. METHODS: A retrospective case-control study comparing the highest documented and corrected PEWS score before unplanned PICU transfer in pediatric oncology patients (129 cases) with matched controls (those not requiring PICU care) was performed...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28877030/radiation-mitigating-properties-of-intranasally-administered-kl4-surfactant-in-a-murine-model-of-radiation-induced-lung-damage
#8
Melpo Christofidou-Solomidou, Ralph A Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, Robert Segal
The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced lung disease can manifest with an acute radiation pneumonitis and/or delayed effects leading to pulmonary fibrosis. As prior warning of radiation exposure is unlikely, medical countermeasures (MCMs) to mitigate radiation-induced lung disease that can be given in mass-casualty situations many hours or days postirradiation are needed to prevent both early and late lung damage...
September 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28874880/monitoring-pertussis-infections-using-internet-search-queries
#9
Yuzhou Zhang, Gabriel Milinovich, Zhiwei Xu, Hilary Bambrick, Kerrie Mengersen, Shilu Tong, Wenbiao Hu
This study aims to assess the utility of internet search query analysis in pertussis surveillance. This study uses an empirical time series model based on internet search metrics to detect the pertussis incidence in Australia. Our research demonstrates a clear seasonal pattern of both pertussis infections and Google Trends (GT) with specific search terms in time series seasonal decomposition analysis. The cross-correlation function showed significant correlations between GT and pertussis incidences in Australia and each state at the lag of 0 and 1 months, with the variation of correlations between 0...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865442/midwives-experiences-of-performing-maternal-observations-and-escalating-concerns-a-focus-group-study
#10
Justine Jeffery, Alistair Hewison, Laura Goodwin, Sara Kenyon
BACKGROUND: For the past decade, Maternal Mortality Reports, published in the United Kingdom every three years, have consistently raised concerns about maternal observations in maternity care. The reports identify that observations are not being done, not being completed fully, are not recorded on Early Warning Score systems, and/or are not escalated appropriately. This has resulted in delays in referral, intervention and increases the risk of maternal morbidity or mortality. However there has been little exploration of the possible reasons for non-completion of maternal observations...
September 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28865000/assessment-of-ddt-contamination-in-house-rat-as-a-possible-bioindicator-in-ddt-sprayed-areas-from-ethiopia-and-south-africa
#11
Yared Beyene Yohannes, Yoshinori Ikenaka, Gengo Ito, Shouta M M Nakayama, Hazuki Mizukawa, Victor Wepener, Nico J Smit, Johan H J Van Vuren, Mayumi Ishizuka
Ethiopia and South Africa are among the few countries to still implement indoor residual spraying with dichloro-diphenyl-trichloroethane (DDT) for malaria vector control. In this study, we investigated the levels and ecological risks of DDT and its metabolites in liver tissues of house rat, as a sentinel animal, for providing an early warning system for public health and wildlife intervention from Ethiopia and South Africa. The results showed that ΣDDT concentration ranged from 127 to 9155 μg/kg wet weight, and the distribution order of DDT and its metabolites in the analyzed liver samples was p,p'-DDD > p,p'-DDE > p,p'-DDT, o,p'-DDT, and o,p'-DDD...
September 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28862084/diagnostic-overshadowing-of-the-psychiatric-population-in-the-emergency-department-physiological-factors-identified-for-an-early-warning-system
#12
Michelle Geiss, Jill Chamberlain, Tamsyn Weaver, Carrie McCormick, Ashley Raufer, Lorna Scoggins, Lindsey Petersen, Shannon Davis, Deborah Edmonson
BACKGROUND: Many people with mental disorders in the United States remain either medically untreated or inadequately treated, which is often attributed to diagnostic overshadowing, a common occurrence across the nation in emergency departments. OBJECTIVE: The aim of this research is to create a tool that supports accurate assessment and distinguishing behavioral symptoms between psychiatric illness and coexisting medical conditions in the emergency department, thus leading to appropriate care and placement...
August 1, 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28859061/is-the-new-zealand-early-warning-score-useful-following-cardiac-surgery
#13
Kevin Niall Peek, Michael Gillham
AIMS: The rate of medical emergency team (MET) calling among post-cardiac surgery patients is unknown. We set out to determine what the call frequency would be if MET activation occurred in every instance that the early warning score (EWS) breached our local threshold, what the outcome was for these patients and what the calling rate might be if the proposed New Zealand EWS (NZEWS) system was implemented with 100% adherence. METHODS: The clinical records of 400 consecutive post-cardiac surgery patients were examined...
September 1, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28854482/applying-high-frequency-surrogate-measurements-and-a-wavelet-ann-model-to-provide-early-warnings-of-rapid-surface-water-quality-anomalies
#14
Bin Shi, Peng Wang, Jiping Jiang, Rentao Liu
It is critical for surface water management systems to provide early warnings of abrupt, large variations in water quality, which likely indicate the occurrence of spill incidents. In this study, a combined approach integrating a wavelet artificial neural network (wavelet-ANN) model and high-frequency surrogate measurements is proposed as a method of water quality anomaly detection and warning provision. High-frequency time series of major water quality indexes (TN, TP, COD, etc.) were produced via a regression-based surrogate model...
August 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28841642/modeling-zoonotic-cutaneous-leishmaniasis-incidence-in-central-tunisia-from-2009-2015-forecasting-models-using-climate-variables-as-predictors
#15
Khouloud Talmoudi, Hedia Bellali, Nissaf Ben-Alaya, Marc Saez, Dhafer Malouche, Mohamed Kouni Chahed
Transmission of zoonotic cutaneous leishmaniasis (ZCL) depends on the presence, density and distribution of Leishmania major rodent reservoir and the development of these rodents is known to have a significant dependence on environmental and climate factors. ZCL in Tunisia is one of the most common forms of leishmaniasis. The aim of this paper was to build a regression model of ZCL cases to identify the relationship between ZCL occurrence and possible risk factors, and to develop a predicting model for ZCL's control and prevention purposes...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28839215/personalized-monitoring-and-advance-warning-system-for-cardiac-arrhythmias
#16
Serkan Kiranyaz, Turker Ince, Moncef Gabbouj
Each year more than 7 million people die from cardiac arrhythmias. Yet no robust solution exists today to detect such heart anomalies right at the moment they occur. The purpose of this study was to design a personalized health monitoring system that can detect early occurrences of arrhythmias from an individual's electrocardiogram (ECG) signal. We first modelled the common causes of arrhythmias in the signal domain as a degradation of normal ECG beats to abnormal beats. Using the degradation models, we performed abnormal beat synthesis which created potential abnormal beats from the average normal beat of the individual...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838035/spatiotemporal-variation-of-hand-foot-mouth-disease-in-relation-to-socioecological-factors-a-multiple-province-analysis-in-vietnam
#17
Dung Phung, Huong Xuan Nguyen, Huong Lien Thi Nguyen, Cuong Manh Do, Quang Dai Tran, Cordia Chu
BACKGROUND: Hand-foot-and-mouth disease (HFMD) is a significant public health issue in Asia-pacific countries. Numerous studies have examined the relationship between socio-ecological factors and HFMD however the research findings were inconsistent. This study examined the association between socio-ecologic factors and HFMD in multiple provinces across Vietnam. METHODS: We applied a spatial autoregressive model using a Bayesian framework to examine the relationship between HFMD and socio-demographic factors...
August 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28835768/several-indicators-of-critical-transitions-for-complex-diseases-based-on-stochastic-analysis
#18
Gang Wang, Yuanyuan Li, Xiufen Zou
Many complex diseases (chronic disease onset, development and differentiation, self-assembly, etc.) are reminiscent of phase transitions in a dynamical system: quantitative changes accumulate largely unnoticed until a critical threshold is reached, which causes abrupt qualitative changes of the system. Understanding such nonlinear behaviors is critical to dissect the multiple genetic/environmental factors that together shape the genetic and physiological landscape underlying basic biological functions and to identify the key driving molecules...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28812374/an-evaluation-scheme-for-assessing-the-effectiveness-of-intersection-movement-assist-ima-on-improving-traffic-safety
#19
Kun-Feng Wu, Nashir Ardiansyah, Wei-Jyun Ye
OBJECTIVE: Intersection Movement Assist (IMA) has been recognized as one of the prominent countermeasures to reduce angle crashes at intersections, which constitute 22 percent of total crashes in the US. Utilizing vehicle-based sensors, vehicle-to-vehicle (V2░V), and vehicle-to-infrastructure (V2I) communications, IMA offers extended vision to provide early warning for an imminent crash. However, most of IMA related research implements their methods and strategies only in simulations, test tracks, or driving simulator studies that have quite a few assumptions and limitations, and hence the effectiveness evaluations reported may not be transferable or comparable...
August 16, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28798957/holographic-deep-learning-for-rapid-optical-screening-of-anthrax-spores
#20
YoungJu Jo, Sangjin Park, JaeHwang Jung, Jonghee Yoon, Hosung Joo, Min-Hyeok Kim, Suk-Jo Kang, Myung Chul Choi, Sang Yup Lee, YongKeun Park
Establishing early warning systems for anthrax attacks is crucial in biodefense. Despite numerous studies for decades, the limited sensitivity of conventional biochemical methods essentially requires preprocessing steps and thus has limitations to be used in realistic settings of biological warfare. We present an optical method for rapid and label-free screening of Bacillus anthracis spores through the synergistic application of holographic microscopy and deep learning. A deep convolutional neural network is designed to classify holographic images of unlabeled living cells...
August 2017: Science Advances
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