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https://www.readbyqxmd.com/read/28549148/risk-factors-for-invasive-fungal-disease-in-pediatric-cancer-and-hematopoietic-stem-cell-transplantation-a-systematic-review
#1
Brian T Fisher, Paula D Robinson, Thomas Lehrnbecher, William J Steinbach, Theoklis E Zaoutis, Bob Phillips, Lillian Sung
Background.: Although a number of risk factors have been associated with invasive fungal disease (IFD), a systematic review of the literature to document pediatric-specific factors has not been performed. Methods.: We used the Ovid SP platform to search Medline, Medline In-Process, and Embase for studies that identified risk factors for IFD in children with cancer or those who undergo hematopoietic stem cell transplantation (HSCT). We included studies if they consisted of children or adolescents (<25 years) who were receiving treatment for cancer or undergoing HSCT and if the study evaluated risk factors among patients with and those without IFD...
May 26, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28549058/histone-deacetylase-adaptation-in-single-ventricle-heart-disease-and-a-young-animal-model-of-right-ventricular-hypertrophy
#2
Weston W Blakeslee, Kimberly M Demos-Davies, Douglas D Lemon, Katharina M Lutter, Maria A Cavasin, Sam Payne, Karin Nunley, Carlin S Long, Timothy A McKinsey, Shelley D Miyamoto
BACKGROUNDHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac disease. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle heart disease of right ventricular morphology (SV), as well as in a rodent model of right ventricular hypertrophy (RVH).METHODSHomogenates of RV explants from non-failing controls and SV children were assayed for HDAC catalytic activity and HDAC isoform expression. Postnatal 1-day old rat pups were placed in hypoxic conditions and echocardiographic analysis, gene expression, HDAC catalytic activity and isoform expression studies of the RV were performed...
May 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28547950/increased-risk-of-thai-childhood-acute-lymphoblastic-leukemia-with-the-mir196a2-t-c-polymorphism
#3
Sarinthorn Rakmanee, Samart Pakakasama, Suradej Hongeng, Sirima Sanguansin, Acharawan Thongmee, Wanida Pongstaporn
Objectives: This study assessed associations of the miR196a2 (rs11614913) T>C polymorphism withsusceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Blood DNA samples from 104 childhood ALL patients and 180 healthy children were studied for the miR-196a2 (rs11614913) polymorphism using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) approach. Results: The frequency of the miR-196a2 (rs11614913) T allele in controls was 0...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28547676/femoral-malrotation-after-surgical-treatment-of-femoral-shaft-fractures-in-children-a-retrospective-ct-based-analysis
#4
Christian Zeckey, Fergal Monsell, Mark Jackson, Philipp Mommsen, Musa Citak, Christian Krettek, Mohamed Omar
BACKGROUND: Rotational malalignment is an important and not always avoidable complication after surgical treatment of femoral shaft fractures. The purpose of this study was to determine the incidence of rotational malalignment in children after surgical treatment of femoral shaft fractures and to identify potential patient- and treatment-related risk factors based on data obtained from CT scans. METHODS: We conducted a retrospective analysis of all patients aged less than 15 years with femoral shaft fractures admitted to our level 1 trauma centre between January 2004 and July 2014...
May 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28547648/clinical-and-phenotypic-differences-in-inflammatory-bowel-disease-among-arab-and-jewish-children-in-israel
#5
Firas Rinawi, Amit Assa, Husam Bashir, Sarit Peleg, Raanan Shamir
BACKGROUND: Data on inflammatory bowel disease (IBD) phenotypes among the Arab population in Israel or in the neighboring Arab countries is scarce. AIM: We aimed to assess differences in disease phenotype among Arab and Jewish children living in Israel. METHODS: We performed a retrospective chart review of pediatric IBD cases, which were diagnosed at the Schneider Children's Medical Center and Ha'Emek Medical Center in Israel between 2000 and 2014...
May 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28547010/language-development-and-impairment-in-children-with-mild-to-moderate-sensorineural-hearing-loss
#6
Lorna F Halliday, Outi Tuomainen, Stuart Rosen
Purpose: The goal of this study was to examine language development and factors related to language impairments in children with mild to moderate sensorineural hearing loss (MMHL). Method: Ninety children, aged 8-16 years (46 children with MMHL; 44 aged-matched controls), were administered a battery of standardized language assessments, including measures of phonological processing, receptive and expressive vocabulary and grammar, word and nonword reading, and parental report of communication skills...
May 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28546940/refractive-errors-among-children-adolescents-and-adults-attending-eye-clinics-in-mexico
#7
Francisco Gomez-Salazar, Abraham Campos-Romero, Humberto Gomez-Campaña, Cinthia Cruz-Zamudio, Mariano Chaidez-Felix, Nidia Leon-Sicairos, Jorge Velazquez-Roman, Hector Flores-Villaseñor, Secundino Muro-Amador, Alma Marlene Guadron-Llanos, Javier J Martinez-Garcia, Joel Murillo-Llanes, Jaime Sanchez-Cuen, Alejando Llausas-Vargas, Gerardo Alapizco-Castro, Ana Irineo-Cabrales, Enrique Graue-Hernandez, Tito Ramirez-Luquin, Adrian Canizalez-Roman
AIM: To assess the proportion of refractive errors in the Mexican population that visited primary care optometry clinics in fourteen states of Mexico. METHODS: Refractive data from 676 856 patients aged 6 to 90y were collected from optometry clinics in fourteen states of Mexico between 2014 and 2015. The refractive errors were classified by the spherical equivalent (SE), as follows: sphere+½ cylinder. Myopia (SE>-0.50 D), hyperopia (SE>+0.50 D), emmetropia (-0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546471/automated-quality-control-of-forced-oscillation-measurements-respiratory-artifact-detection-with-advanced-feature-extraction
#8
Thuy T Pham, Philip H W Leong, Paul David Robinson, Thomas Gutzler, Adelle S Jee, Gregory G King, Cindy Thamrin
The forced oscillation technique (FOT) can provide unique and clinically relevant lung function information with little cooperation with subjects. However, FOT has higher variability than spirometry, possibly because strategies for quality control and reducing artifacts in FOT measurements have yet to be standardized or validated. Many quality control procedures either rely on simple statistical filters or subjective evaluation by a human operator. In this study, we propose an automated artifact removal approach based on the resistance against flow profile, applied to complete breaths...
May 25, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28546440/albuminuria-proteinuria-and-renal-disease-progression-in-children-with-ckd
#9
Dana Y Fuhrman, Michael F Schneider, Katherine M Dell, Tom D Blydt-Hansen, Robert Mak, Jeffrey M Saland, Susan L Furth, Bradley A Warady, Marva M Moxey-Mims, George J Schwartz
BACKGROUND AND OBJECTIVES: The role of albuminuria as an indicator of progression has not been investigated in children with CKD in the absence of diabetes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Children were enrolled from 49 centers of the CKD in Children study between January of 2005 and March of 2014. Cross-sectional multivariable linear regression (n=647) was used to examine the relationship between urine protein-to-creatinine (UP/C [milligrams per milligram]) and albumin-to-creatinine (ACR [milligrams per gram]) with eGFR (milliliters per minute per 1...
May 25, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28546104/development-of-a-paediatric-physiologically-based-pharmacokinetic-model-to-assess-the-impact-of-drug-drug-interactions-in-tuberculosis-co-infected-malaria-subjects-a-case-study-with-artemether-lumefantrine-and-the-cyp3a4-inducer-rifampicin
#10
Olusola Olafuyi, Michael Coleman, Raj K S Badhan
The fixed dosed combination of artemether and lumefantrine (AL) is widely used for the treatment of malaria in adults and children in sub-Sahara Africa, with lumefantrine day 7 concentrations being widely used as a marker for clinical efficacy. Both are substrates for CYP3A4 and susceptible to drug-drug interactions (DDIs); indeed, knowledge of the impact of these factors is currently sparse in paediatric population groups. Confounding malaria treatment is the co-infection of patients with tuberculosis. The concomitant treatment of AL with tuberculosis chemotherapy, which includes the CYP3A4 inducer rifampicin, increases the risk of parasite recrudescence and malaria treatment failure...
May 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28546095/puberty-suppression-in-transgender-children-and-adolescents
#11
REVIEW
Simone Mahfouda, Julia K Moore, Aris Siafarikas, Florian D Zepf, Ashleigh Lin
The World Professional Association for Transgender Health's standards of care recommend suspending puberty, preferably with the use of gonadotropin-releasing hormone agonists, in certain gender non-conforming minors (aged under 18 years) who have undergone a psychiatric assessment and have reached at least Tanner stage II of puberty. This approach seeks to lessen the discordance between assigned natal sex and gender identity by temporarily halting the development of secondary sexual characteristics, essentially widening the temporal window for gender clarification...
May 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28545887/how-to-identify-high-radiation-burden-from-computed-tomography-an-example-in-obese-children
#12
Daniel L Lodwick, Jennifer N Cooper, Brent Adler, Choonsik Lee, Kelly Kelleher, Peter C Minneci, Katherine J Deans
BACKGROUND: Radiation burden from the use of computed tomography (CT) imaging may not be evenly distributed. We tested whether overweight and obese children receive higher radiation burden from CT imaging. METHODS: An automated software tool (DoseWizard) assessed patient-level radiation dose from CT and merged results with clinical data from the electronic health record. CT scans of the head, chest, and abdomen/pelvis (A/P) performed at our institution from January 2013 to August 2015 on patients aged <16 y were processed using this software...
May 5, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28545823/novel-molecular-subgroups-for-clinical-classification-and-outcome-prediction-in-childhood-medulloblastoma-a-cohort-study
#13
Edward C Schwalbe, Janet C Lindsey, Sirintra Nakjang, Stephen Crosier, Amanda J Smith, Debbie Hicks, Gholamreza Rafiee, Rebecca M Hill, Alice Iliasova, Thomas Stone, Barry Pizer, Antony Michalski, Abhijit Joshi, Stephen B Wharton, Thomas S Jacques, Simon Bailey, Daniel Williamson, Steven C Clifford
BACKGROUND: International consensus recognises four medulloblastoma molecular subgroups: WNT (MBWNT), SHH (MBSHH), group 3 (MBGrp3), and group 4 (MBGrp4), each defined by their characteristic genome-wide transcriptomic and DNA methylomic profiles. These subgroups have distinct clinicopathological and molecular features, and underpin current disease subclassification and initial subgroup-directed therapies that are underway in clinical trials. However, substantial biological heterogeneity and differences in survival are apparent within each subgroup, which remain to be resolved...
May 22, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28545398/advanced-glycation-end-products-in-children-with-type-1-diabetes-and-early-reduced-diastolic-heart-function
#14
Leif Brunvand, Martin Heier, Cathrine Brunborg, Kristian F Hanssen, Drude Fugelseth, Knut Haakon Stensaeth, Knut Dahl-Jørgensen, Hanna Dis Margeirsdottir
BACKGROUND: Reduced diastolic function is an early sign of diabetes cardiomyopathy in adults and is associated with elevated levels of HbA1c and advanced glycation end products (AGEs). OBJECTIVE: To assess the associations between early reduced diastolic function and elevated levels of HbA1c and AGEs in children and adolescents with type 1 diabetes (T1D). METHODS: One hundred fourty six T1D patients (age 8-18 years) without known diabetic complications were examined with tissue Doppler imaging and stratified into two groups according to diastolic function...
May 25, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28544732/similar-familial-underpinnings-for-full-and-subsyndromal-pediatric-bipolar-disorder-a-familial-risk-analysis
#15
Janet Wozniak, Mai Uchida, Stephen V Faraone, Maura Fitzgerald, Carrie Vaudreuil, Nicholas Carrellas, Jacqueline Davis, Rebecca Wolenski, Joseph Biederman
OBJECTIVES: To examine the validity of subthreshold pediatric bipolar I disorder (BP-I), we compared the familial risk for BP-I in the child probands who had either full BP-I, subthreshold BP-I, ADHD, or were controls that neither had ADHD nor bipolar disorder. METHODS: BP-I probands were youth aged 6-17 years meeting criteria for BP-I, full (N=239) or subthreshold (N=43), and also included were their first-degree relatives (N=687 and N=120, respectively). Comparators were youth with ADHD (N=162), controls without ADHD or bipolar disorder (N=136), and their first-degree relatives (N=511 and N=411, respectively)...
May 22, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28544700/income-inequality-and-traumatic-dental-injuries-in-12-years-old-children-a-multi-level-analysis
#16
Mario Vianna Vettore, Salma Efhima, Carolina Machuca, Gabriela de Almeida Lamarca
BACKGROUND/AIM: Contextual socioeconomic factors have been associated with traumatic dental injuries (TDIs). However, evidence concerning the role of income inequality on TDIs in children is scarce.The aim of this study was to investigate the association between contextual income inequality over a ten-year period and TDIs in Brazilian children. SUBJECTS AND METHODS: The study population comprised a representative sample of 5027 children aged 12 years who participated in the Brazilian oral health survey in 2010...
May 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28543958/latent-structure-of-negative-valence-measures-in-childhood
#17
Minyoung Lee, Steven H Aggen, Dever M Carney, Shannon Hahn, Elizabeth Moroney, Laura Machlin, Melissa A Brotman, Kenneth E Towbin, Ellen Leibenluft, Daniel S Pine, Roxann Roberson-Nay, John M Hettema
BACKGROUND: Internalizing disorders (IDs), consisting of the syndromes of anxiety and depression, are common, debilitating conditions often having onsets in adolescence. Scientists have developed dimensional self-report instruments that assess putative negative valence system (NVS) trait-like constructs as complimentary phenotypes to clinical symptoms. These include various measures that index temperamental predispositions to IDs and correlate with neural substrates of fear, anxiety, and affective regulation...
May 22, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28543847/validation-of-sensewear-armband-in-children-adolescents-and-adults
#18
Guillermo Antonio Lopez, Jan Christian Brønd, Lars Bo Andersen, Magnus Dencker, Daniel Arvidsson
BACKGROUND: SenseWear Armband (SW) is a multisensor monitor to assess physical activity and energy expenditure. Its prediction algorithms have been updated periodically. PURPOSE: To validate SW in children, adolescents and adults. METHODS: The most recent SW algorithm 5.2 (SW5.2) and the previous version 2.2 (SW2.2) were evaluated for estimation of energy expenditure during semi-structured activities in 35 children, 31 adolescents and 36 adults with indirect calorimetry as reference...
May 24, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28543781/fracture-prospectively-recorded-from-pre-puberty-to-young-adulthood-are-they-markers-of-peak-bone-mass-and-strength-in-males
#19
Chevalley T, J-P Bonjour, M-C Audet, F Merminod, B van Rietbergen, R Rizzoli, S Ferrari
Fractures are common in otherwise healthy children and adolescents. They result from trauma of varying severity. Some reflect a greater skeletal fragility. A long-term implication of these fractures is their potentiality to predict adult bone fragility and increased risk of osteoporosis in later life. Using DXA, HR-pQCT and µFEA measurements, we previously found in 124 healthy females followed from the age of 7.9 to 20.4 years, substantial deficits in both structural and strength components of the radius in the 42 girls who sustained a fracture during skeletal development...
May 24, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28543302/a-randomised-controlled-trial-of-an-ipad-based-application-to-complement-early-behavioural-intervention-in-autism-spectrum-disorder
#20
Andrew J O Whitehouse, Joanna Granich, Gail Alvares, Margherita Busacca, Matthew N Cooper, Alena Dass, Thi Duong, Rajes Harper, Wendy Marshall, Amanda Richdale, Tania Rodwell, David Trembath, Pratibha Vellanki, Dennis W Moore, Angelika Anderson
BACKGROUND: Technology-based interventions for Autism Spectrum Disorder (ASD) have proliferated, but few have been evaluated within the context of a randomised controlled trial (RCT). This RCT evaluated the efficacy of one technology-based early intervention programme (Therapy Outcomes By You; TOBY) in young children with ASD. METHODS: TOBY is an app-based learning curriculum designed for children and parents as a complement to early behavioural intervention. Eighty children (16 female) were recruited to this RCT within 12 months of receiving a diagnosis of ASD (M age = 3...
May 25, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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