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IgA bullous dermatosis

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https://www.readbyqxmd.com/read/28623863/linear-immunoglobulin-a-g-bullous-dermatosis-associated-with-ulcerative-colitis
#1
Asuka Onoe, Daisuke Matsuura, Tadashi Terui, Norito Ishii, Takashi Hashimoto, Toyoko Ochiai
Linear immunoglobulin (Ig)A/G bullous dermatosis (LAGBD) is an autoimmune bullous disease characterized by formation of subepidermal blisters and linear deposition of IgA and IgG antibodies along the basement membrane zone (BMZ). The association between linear IgA bullous dermatosis and ulcerative colitis (UC) is well recognized, but reports of UC-associated LAGBD are lacking. We have reported a 24-year-old man suffering from LAGBD associated with UC, which occurred before exacerbations of skin rash. A skin biopsy indicated a subepidermal blister with an infiltration of primarily neutrophils and eosinophils in the dermis...
June 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28533859/-a-particular-type-of-cicatricial-pemphigoid-with-unique-iga-deposit
#2
Amina Aounallah, Mariem Jrad, Mehdi Ksiaa, Sana Mokni, Wafa Saidi, Lobna Boussofara, Badreddine Sriha, Mohamed Denguezli, Najet Ghariani, Colandane Belajouza, Rafia Nouira
Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Gingival biopsy revealed a necrotic detachment of the buccal epithelium...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28497856/case-of-shift-from-linear-immunoglobulin-a-bullous-dermatosis-to-pemphigus-herpetiformis-for-a-short-period-of-time
#3
Hiroshi Koga, Norito Ishii, Takashi Hashimoto, Takekuni Nakama
Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). The annular-shaped skin lesions in PH mimic clinical manifestation of other autoimmune bullous diseases, including LABD, although PH and LABD have different immunological and histopathological features...
February 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28338219/human-orf-complicated-by-epidermolysis-bullosa-acquisita
#4
E Zuelgaray, C Salle de Chou, J Gottlieb, M Battistella, M D Vignon-Pennamen, M Bagot, F Guibal, J D Bouaziz
Orf is a DNA parapoxvirus transmitted to humans by contact with infected goats and sheep. Many complications have been reported after Orf infection including erythema multiforme. A few cases of auto-immune bullous dermatosis complicating Orf disease have been reported to date, usually characterized by tense blisters eruptions with or without mucosal involvement, linear deposition of C3, IgG and/or IgA along the basement membrane and negativity of indirect immunofluorescence analysis and ELISA assays (performed in 4 of 11 reported cases) against target antigens of bullous pemphigoid, mucous membrane pemphigoid or epidermolysis bullosa acquisita, except one case of mucosal pemphigoid with antilaminin-332 antibodies...
March 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28300887/linear-iga-and-igg-bullous-dermatosis
#5
Karina de Almeida Pinto Fernandes, Kely Hernández Galvis, Anndressa Camillo da Matta Setubal Gomes, Osvania Maris Nogueira, Paulo Antônio Oldani Felix, Thiago Jeunon de Sousa Vargas
Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28168063/a-rare-case-of-vancomycin-induced-linear-immunoglobulin-a-bullous-dermatosis
#6
Pinky Jha, Kurtis Swanson, Jeremiah Stromich, Basia M Michalski, Edit Olasz
Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28108048/bullous-pseudobullous-pustular-dermatoses
#7
REVIEW
Mark R Wick
Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Examples of such disorders include impetigo, Herpes virus infections, pemphigus, bullous pemphigoid and pemphigoid gestationis, epidermolysis bullosa acquisita, IgA-related dermatoses, inherited epidermolysis bullosa variants, Hailey-Hailey disease, and porphyria cutanea tarda...
May 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28079922/iga-tracheobronchial-deposits-underlie-respiratory-compromise-in-neonatal-linear-iga-bullous-dermatosis
#8
LETTER
A Diociaiuti, G Zambruno, F Diomedi Camassei, G Di Zenzo, I Capolupo, F Stoppa, V Forziati, M El Hachem
No abstract text is available yet for this article.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28003921/bullous-dermatosis-in-an-end-stage-renal-disease-patient-a-case-report-and-literature-review
#9
Zeenat Yousuf Bhat, Marwan Abu Minshar, Nashat Imran, Andrew Thompson, Yahya Osman Malik
Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic possibilities, and subsequent rise of a puzzling diagnostic challenge. We describe an ESRD patient who presented with blistering, nonhealing ulcerative lesions with a diagnostic skin biopsy revealing a mixed pattern of linear IgA bullous dermatosis and dermatitis herpetiformis...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27995619/idiopathic-linear-iga-bullous-dermatosis-prognostic-factors-based-on-a-case-series-of-72-adults
#10
J Gottlieb, S Ingen-Housz-Oro, M Alexandre, S Grootenboer-Mignot, F Aucouturier, E Sbidian, E Tancrede, P Schneider, E Regnier, C Picard-Dahan, E Begon, C Pauwels, K Cury, S Hüe, C Bernardeschi, N Ortonne, F Caux, P Wolkenstein, O Chosidow, C Prost-Squarcioni
BACKGROUND: Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune blistering disease (AIBD), whose long-term evolution is poorly described. OBJECTIVES: To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD. METHODS: This retrospective study, conducted in our AIBD Referral Center, included adults, diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence...
December 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27943257/a-clinical-and-serological-study-of-linear-iga-bullous-dermatosis-without-linear-immunoglobulin-deposition-other-than-iga-at-the-basement-membrane-zone-using-direct-immunofluorescence
#11
C Ohata, N Ishii, H Koga, T Nakama
BACKGROUND: Linear IgA bullous dermatosis (LABD) is a heterogeneous disease. Different diagnostic criteria have been used in different reports. OBJECTIVES: To reappraise the characteristic features of LABD with only IgA deposition at the basement membrane zone (BMZ) with direct immunofluorescence (DIF). METHODS: We retrospectively collected data from 101 patients from our archival records from 1 January 1996 to 31 December 2014 who had: (i) blisters on the skin and/or mucous membranes; (ii) subepidermal blisters in a biopsy specimen; and (iii) linear IgA deposition along the BMZ with/without linear C3 deposition at the BMZ with DIF...
December 11, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27914107/non-paraneoplastic-autoimmune-subepidermal-bullous-disease-associated-with-fatal-bronchiolitis-obliterans
#12
Mari Orime, Katsuhiro Tomiyama, Hideki Hashidate, Satoru Yoshida, Satoshi Hokari, Akiko Tsuda, Hisashi Yokoyama, Jun-Ichi Narita, Youhei Uchida, Takuro Kanekura, Riichiro Abe, Norito Ishii, Takashi Hashimoto, Kazuhiro Kawai
Bronchiolitis obliterans is a small-airway obstructive lung disease for which immunologically mediated pathogenesis is supposed. Frequent association of bronchiolitis obliterans with paraneoplastic pemphigus is well known, but its association with other autoimmune bullous diseases has not been reported except for a case of anti-laminin-332-type mucous membrane pemphigoid in a patient with chronic graft-versus-host disease. We report a case of non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans in a patient without transplantation...
April 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/27882389/linear-iga-bullous-dermatosis-associated-with-immunoglobulin-light-chain-amyloidosis
#13
Yasuyuki Yamaguchi, Hideyuki Ujiie, Hiroyuki Ohigashi, Hiroyuki Iwata, Ken Muramatsu, Tomoyuki Endou, Takanori Teshima, Hiroshi Shimizu
No abstract text is available yet for this article.
April 6, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27878477/paraneoplastic-pemphigus-and-autoimmune-blistering-diseases-associated-with-neoplasm-characteristics-diagnosis-associated-neoplasms-proposed-pathogenesis-treatment
#14
REVIEW
Saritha Kartan, Vivian Y Shi, Ashley K Clark, Lawrence S Chan
Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Autoimmune paraneoplastic and neoplasm-associated bullous skin syndromes are characterized by blister formation due to an autoimmune response to components of the epidermis or basement membrane in the context of a neoplasm...
February 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27814422/development-of-bullous-pemphigoid-in-a-patient-with-psoriasis-and-metabolic-syndrome
#15
Anna Lesniewska, Agnieszka Kalińska-Bienias, Cezary Kowalewski, Robert Schwartz, Katarzyna Wozniak
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that most commonly affects adults older than 60 years, whereas psoriasis vulgaris (PV) is a chronic immune-mediated disease that affects both children and adults. Bullous pemphigoid and PV may coexist with each other as well as with various other internal disorders, which may lead to early death. We report the case of a 35-year-old man with a 15-year history of PV and obesity who developed tense blisters with annular arrangement and normal-appearing perilesional skin localized mainly on the trunk, arms, and legs resembling linear IgA bullous dermatosis...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27746656/a-case-of-linear-iga-bullous-dermatosis-associated-with-systemic-lupus-erythematosus
#16
Ho-June Lee, Sook Jung Yun, Seung-Chul Lee, Jee-Bum Lee
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27684497/anti-p200-laminin-%C3%AE-1-pemphigoid-associated-with-metastatic-oesophageal-cancer
#17
LETTER
S Goetze, A-K Dumke, D Zillikens, U C Hipler, P Elsner
No abstract text is available yet for this article.
April 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27681233/vancomycin-associated-henoch-sch%C3%A3-nlein-purpura
#18
Zaw Min, Raquel R Garcia, Monika Murillo, Jeffrey M Uchin, Nitin Bhanot
Intravenous vancomycin is a widely used antibiotics, but it causes different types of cutaneous hypersensitivity reactions, ranging from maculopapular rash, red-man syndrome, drug rash with eosinophilia and systemic symptoms, IgA bullous dermatosis, leukocytoclastic vasculitis, Stevens-Johnsons syndrome, to IgE-mediated anaphylaxis. We report an elderly patient with the end-stage renal disease presented with diffuse palpable purpura while receiving IV vancomycin therapy for methicillin-resistant Staphylococcus aureus septicemia...
March 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27617457/vancomycin-induced-linear-iga-bullous-dermatosis-associations
#19
REVIEW
Ana Gameiro, Miguel Gouveia, Oscar Tellechea, Margarida Goncalo
UNLABELLED: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases.We reviewed previous reports of VCM-induced LABD and analyzed the following parameters: gender, age, recent medical history, concurrent medication, latency period, progression after withdrawal, time to resolution, treatment, and rechallenge...
April 18, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27258999/clinical-and-immunological-studies-of-49-cases-of-various-types-of-intercellular-iga-dermatosis-and-13-cases-of-classical-subcorneal-pustular-dermatosis-examined-at-kurume-university
#20
T Hashimoto, K Teye, N Ishii
BACKGROUND: Intercellular IgA dermatosis (IAD) is a subset of autoimmune bullous disease exclusively with IgA antikeratinocyte cell-surface antibodies. The classification and pathogenesis of this condition are still obscure. OBJECTIVES: To classify IAD and study its pathogenesis. METHODS: From our cohort of 5402 cases of autoimmune bullous disease, we selected 49 cases of various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were available...
January 2017: British Journal of Dermatology
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