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IgA bullous dermatosis

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https://www.readbyqxmd.com/read/28300887/linear-iga-and-igg-bullous-dermatosis
#1
Karina de Almeida Pinto Fernandes, Kely Hernández Galvis, Anndressa Camillo da Matta Setubal Gomes, Osvania Maris Nogueira, Paulo Antônio Oldani Felix, Thiago Jeunon de Sousa Vargas
Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28168063/a-rare-case-of-vancomycin-induced-linear-immunoglobulin-a-bullous-dermatosis
#2
Pinky Jha, Kurtis Swanson, Jeremiah Stromich, Basia M Michalski, Edit Olasz
Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28108048/bullous-pseudobullous-pustular-dermatoses
#3
Mark R Wick
Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Examples of such disorders include impetigo, Herpes virus infections, pemphigus, bullous pemphigoid and pemphigoid gestationis, epidermolysis bullosa acquisita, IgA-related dermatoses, inherited epidermolysis bullosa variants, Hailey-Hailey disease, and porphyria cutanea tarda...
December 14, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28079922/iga-tracheobronchial-deposits-underlie-respiratory-compromise-in-neonatal-linear-iga-bullous-dermatosis
#4
LETTER
A Diociaiuti, G Zambruno, F Diomedi Camassei, G Di Zenzo, I Capolupo, F Stoppa, V Forziati, M El Hachem
No abstract text is available yet for this article.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28003921/bullous-dermatosis-in-an-end-stage-renal-disease-patient-a-case-report-and-literature-review
#5
Zeenat Yousuf Bhat, Marwan Abu Minshar, Nashat Imran, Andrew Thompson, Yahya Osman Malik
Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic possibilities, and subsequent rise of a puzzling diagnostic challenge. We describe an ESRD patient who presented with blistering, nonhealing ulcerative lesions with a diagnostic skin biopsy revealing a mixed pattern of linear IgA bullous dermatosis and dermatitis herpetiformis...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27995619/idiopathic-linear-iga-bullous-dermatosis-prognostic-factors-based-on-a-case-series-of-72-adults
#6
J Gottlieb, S Ingen-Housz-Oro, M Alexandre, S Grootenboer-Mignot, F Aucouturier, E Sbidian, E Tancrede, P Schneider, E Regnier, C Picard-Dahan, E Begon, C Pauwels, K Cury, S Hüe, C Bernardeschi, N Ortonne, F Caux, P Wolkenstein, O Chosidow, C Prost-Squarcioni
BACKGROUND: Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune blistering disease (AIBD), whose long-term evolution is poorly described. OBJECTIVES: To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD. METHODS: This retrospective study, conducted in our AIBD Referral Center, included adults, diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence...
December 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27943257/a-clinical-and-serological-study-of-linear-iga-bullous-dermatosis-without-linear-immunoglobulin-deposition-other-than-iga-at-the-basement-membrane-zone-in-direct-immunofluorescence
#7
C Ohata, N Ishii, H Koga, T Nakama
BACKGROUND: Linear IgA bullous dermatosis (LABD) is a heterogeneous disease. Different diagnostic criteria have been used in different reports. OBJECTIVES: We aimed to reappraise the characteristic features of LABD with only IgA deposition at the basement membrane zone (BMZ) in direct immunofluorescence (DIF). METHODS: We retrospectively collected 101 patients who had a) blisters on the skin and/or mucous membrane, b) subepidermal blisters in a biopsy specimen, and c) linear IgA deposition along BMZ with/without linear C3 deposition at the BMZ in DIF from our archival records from January 1, 1996, through December 31, 2014...
December 11, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27914107/non-paraneoplastic-autoimmune-subepidermal-bullous-disease-associated-with-fatal-bronchiolitis-obliterans
#8
Mari Orime, Katsuhiro Tomiyama, Hideki Hashidate, Satoru Yoshida, Satoshi Hokari, Akiko Tsuda, Hisashi Yokoyama, Jun-Ichi Narita, Youhei Uchida, Takuro Kanekura, Riichiro Abe, Norito Ishii, Takashi Hashimoto, Kazuhiro Kawai
Bronchiolitis obliterans is a small-airway obstructive lung disease for which immunologically mediated pathogenesis is supposed. Frequent association of bronchiolitis obliterans with paraneoplastic pemphigus is well known, but its association with other autoimmune bullous diseases has not been reported except for a case of anti-laminin-332-type mucous membrane pemphigoid in a patient with chronic graft-versus-host disease. We report a case of non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans in a patient without transplantation...
December 3, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27882389/linear-iga-bullous-dermatosis-associated-with-immunoglobulin-light-chain-amyloidosis
#9
Yasuyuki Yamaguchi, Hideyuki Ujiie, Hiroyuki Ohigashi, Hiroyuki Iwata, Ken Muramatsu, Tomoyuki Endou, Takanori Teshima, Hiroshi Shimizu
is missing (Short communication).
November 24, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27878477/paraneoplastic-pemphigus-and-autoimmune-blistering-diseases-associated-with-neoplasm-characteristics-diagnosis-associated-neoplasms-proposed-pathogenesis-treatment
#10
REVIEW
Saritha Kartan, Vivian Y Shi, Ashley K Clark, Lawrence S Chan
Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Autoimmune paraneoplastic and neoplasm-associated bullous skin syndromes are characterized by blister formation due to an autoimmune response to components of the epidermis or basement membrane in the context of a neoplasm...
February 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27814422/development-of-bullous-pemphigoid-in-a-patient-with-psoriasis-and-metabolic-syndrome
#11
Anna Lesniewska, Agnieszka Kalińska-Bienias, Cezary Kowalewski, Robert Schwartz, Katarzyna Wozniak
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that most commonly affects adults older than 60 years, whereas psoriasis vulgaris (PV) is a chronic immune-mediated disease that affects both children and adults. Bullous pemphigoid and PV may coexist with each other as well as with various other internal disorders, which may lead to early death. We report the case of a 35-year-old man with a 15-year history of PV and obesity who developed tense blisters with annular arrangement and normal-appearing perilesional skin localized mainly on the trunk, arms, and legs resembling linear IgA bullous dermatosis...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27746656/a-case-of-linear-iga-bullous-dermatosis-associated-with-systemic-lupus-erythematosus
#12
Ho-June Lee, Sook Jung Yun, Seung-Chul Lee, Jee-Bum Lee
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27684497/anti-p200-laminin-%C3%AE-1-pemphigoid-associated-with-metastatic-oesophageal-cancer
#13
LETTER
S Goetze, A-K Dumke, D Zillikens, U C Hipler, P Elsner
No abstract text is available yet for this article.
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27681233/vancomycin-associated-henoch-sch%C3%A3-nlein-purpura
#14
Zaw Min, Raquel R Garcia, Monika Murillo, Jeffrey M Uchin, Nitin Bhanot
Intravenous vancomycin is a widely used antibiotics, but it causes different types of cutaneous hypersensitivity reactions, ranging from maculopapular rash, red-man syndrome, drug rash with eosinophilia and systemic symptoms, IgA bullous dermatosis, leukocytoclastic vasculitis, Stevens-Johnsons syndrome, to IgE-mediated anaphylaxis. We report an elderly patient with the end-stage renal disease presented with diffuse palpable purpura while receiving IV vancomycin therapy for methicillin-resistant Staphylococcus aureus septicemia...
September 25, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27617457/vancomycin-induced-linear-iga-bullous-dermatosis-associations
#15
Ana Gameiro, Miguel Gouveia, Oscar Tellechea, Margarida Goncalo
UNLABELLED: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases.We reviewed previous reports of VCM-induced LABD and analyzed the following parameters: gender, age, recent medical history, concurrent medication, latency period, progression after withdrawal, time to resolution, treatment, and rechallenge...
April 18, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27258999/clinical-and-immunological-studies-of-49-cases-of-various-types-of-intercellular-iga-dermatosis-and-13-cases-of-classical-subcorneal-pustular-dermatosis-examined-at-kurume-university
#16
T Hashimoto, K Teye, N Ishii
BACKGROUND: Intercellular IgA dermatosis (IAD) is a subset of autoimmune bullous disease exclusively with IgA antikeratinocyte cell-surface antibodies. The classification and pathogenesis of this condition are still obscure. OBJECTIVES: To classify IAD and study its pathogenesis. METHODS: From our cohort of 5402 cases of autoimmune bullous disease, we selected 49 cases of various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were available...
January 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/27156746/immune-mediated-reactions-to-vancomycin-a-systematic-case-review-and-analysis
#17
Jasmit S Minhas, Paige G Wickner, Aidan A Long, Aleena Banerji, Kimberly G Blumenthal
BACKGROUND: Vancomycin is a broad-spectrum antibiotic whose use may be limited by adverse drug reactions (ADRs). Although vancomycin toxic effects are known, there are limited data on vancomycin hypersensitivity reactions (HSRs). OBJECTIVE: To understand the most commonly reported vancomycin HSRs through systematic case review. METHODS: We performed a literature search for English-language case reports and series from 1982 through 2015 (last search July 31, 2015) on Ovid MEDLINE and PubMed...
June 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27051795/urticarial-linear-iga-bullous-dermatosis-labd-as-a-presenting-sign-of-chronic-lymphocytic-leukemia-cll
#18
Jeffrey B Tiger, Jessica T Rush, Dorothea T Barton, Alexey V Danilov, M Shane Chapman
No abstract text is available yet for this article.
November 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/26969825/pemphigus-vulgaris-associated-interstitial-lung-disease
#19
Yi-Xiu Bai, Jin-Gang Chu, Ting Xiao, Hong-Duo Chen
Autoimmune bullous diseases (AIBDs)-associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV-associated ILD has rarely been reported in English literature. We report a rare association of PV and ILD. A 53-year-old Chinese female with PV for 8 months developed ILD after a relapse of PV for 2 months due to discontinuation of oral prednisone by herself. She was successfully treated by systemic methylprednisolone...
July 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/26915949/a-subepidermal-blistering-disorder
#20
Yusuf Moolla
A young woman presented with generalised tense blisters. There had been no previous drug exposure and she had no clinical signs of autoimmune disease or evidence of sepsis. Given the abrupt onset and clinical scenario, a skin punch biopsy was performed and a tentative diagnosis of linear IgA bullous dermatosis (LABD) was made. Dapsone, an immunomodulatory sulfone that has been supported for use in LABD by case reports and clinical observation, was administered with an adjunctive oral corticosteroid to accelerate resolution...
March 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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