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https://www.readbyqxmd.com/read/28727763/loss-of-receptor-activity-modifying-protein-2-in-mice-causes-placental-dysfunction-and-alters-pth1r-regulation
#1
Mahita Kadmiel, Brooke C Matson, Scott T Espenschied, Patricia M Lenhart, Kathleen M Caron
Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function. Ramp2 has been primarily characterized in association with calcitonin receptor-like receptor (Calcrl, CLR), forming the canonical receptor complex for the endocrine peptide adrenomedullin (Adm, AM). However, we previously demonstrated that Ramp2+/- female mice display a constellation of endocrine-related phenotypes that are distinct from those of Adm+/- and Calcrl+/- mice, implying that RAMP2 has physiological functions beyond its canonical complex...
2017: PloS One
https://www.readbyqxmd.com/read/28724843/the-complex-structure-of-the-mouse-placental-labyrinth-revealed-by-double-immunofluorescence-labeling-of-slc2a1-and-gjb2
#2
Chaw Kyi-Tha-Thu, Toshihiro Takizawa
No abstract text is available yet for this article.
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28719646/a-synergistic-negative-effect-of-gestational-smoke-exposure-and-small-litter-size-on-rat-placental-efficiency-vascularisation-and-angiogenic-factors-mrna-expression
#3
Zhen-Yan Chen, Ying Yao
Smoking increases the risk of pregnancy complications such as spontaneous abortion and low birth weight (LBW). By cigarette smoke exposure (gestational day, GD3-17), normal-litter-size pregnancy with low birth weight (NP-LBW) and small-litter-size pregnancy with normal birth weight (SP-NBW) in rats were induced. The placental weight in SP-NBW was twice the weight of the normal in contrast with the smaller placenta in NP-LBW. Compared with the normal, placental efficiency (expressed as fetus-to-placenta weight ratio) and placental vascularisation were significantly decreased in smoke exposed placentas with more obvious decrease in SP-NBW...
2017: PloS One
https://www.readbyqxmd.com/read/28717241/sca-1-identifies-a-trophoblast-population-with-multipotent-potential-in-the-mid-gestation-mouse-placenta
#4
Bryony V Natale, Christina Schweitzer, Martha Hughes, Maria A Globisch, Ramie Kotadia, Emilie Tremblay, Priscilla Vu, James C Cross, David R C Natale
Trophoblast stem (TS) cells in the mouse derive from the polar trophectoderm of the blastocyst and persist through early gestation (to E8.5) to support placental development. Further development and growth is proposed to rely on layer-restricted progenitor cells. Stem cell antigen (Sca) -1 is a member of the Ly6 gene family and a known marker of stem cells in both hematopoietic and non-hematopoietic mouse tissues. Having identified that Sca-1 mRNA was highly expressed in mouse TS cells in culture, we found that it was also expressed in a subset of trophoblast within the chorion and labyrinth layer of the mouse placenta...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715749/self-assembly-of-zinc-hydroxystannate-on-amorphous-hydrous-tio2-solid-sphere-for-enhancing-fire-safety-of-epoxy-resin
#5
Wei Wang, Yongchun Kan, Jiajia Liu, Kim Meow Liew, Lei Liu, Yuan Hu
Zinc hydroxystannate (ZHS) was fabricated on the surface of amorphous hydrous TiO2 solid spheres (AHTSS) via a layer-by-layer method for improving the fire safety of epoxy resin. AHTSS@PEI@ZHS was prepared by self-assembly of AHTSS, PEI and ZHS. The well-organized fabrication process was proved by TEM, XPS, XRD and SEM tests. TG results illustrated that the incorporation of AHTSS@PEI@ZHS show a higher residue compared with the addition of AHTSS or ZHS alone. In addition, AHTSS@PEI@ZHS filled EP composites exhibits improved flame retardancy and smoke suppression properties evaluated by cone calorimeter test...
June 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28705044/the-genetics-of-hair-cell-function-in-zebrafish
#6
Teresa Nicolson
Our ears are remarkable sensory organs, providing the important senses of balance and hearing. The complex structure of the inner ear, or 'labyrinth', along with the assorted neuroepithelia, have evolved to detect head movements and sounds with impressive sensitivity. The rub is that the inner ear is highly vulnerable to genetic lesions and environmental insults. According to National Institute of Health estimates, hearing loss is one of the most commonly inherited or acquired sensorineural diseases. To understand the causes of deafness and balance disorders, it is imperative to understand the underlying biology of the inner ear, especially the inner workings of the sensory receptors...
July 13, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28688556/pediatric-langerhans-cell-histiocytosis-of-the-lateral-skull-base
#7
Ananya Majumder, Cameron C Wick, Rebecca Collins, Timothy N Booth, Brandon Isaacson, J Walter Kutz
OBJECTIVE: Describe the presentation, imaging characteristics, management, and outcomes of pediatric patients with Langerhans cell histiocytosis (LCH) of the temporal bone. METHODS: A retrospective chart review was performed between 2000 and 2014 at a single tertiary care children's hospital. Fourteen patients were identified with a diagnosis of LCH and involvement of the temporal bone. RESULTS: Ten patients were female and ten were Caucasian...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28686887/can-the-exposure-of-apis-mellifera-hymenoptera-apiadae-larvae-to-a-field-concentration-of-thiamethoxam-affect-newly-emerged-bees
#8
Priscila Sepúlveda Friol, Aline Fernanda Catae, Daiana Antonia Tavares, Osmar Malaspina, Thaisa Cristina Roat
The use of insecticides on crops can affect non-target insects, such as bees. In addition to the adult bees, larvae can be exposed to the insecticide through contaminated floral resources. Therefore, this study aimed to investigate the possible effects of the exposure of A. mellifera larvae to a field concentration of thiamethoxam (0.001 ng/μL thiamethoxam) on larval and pupal survival and on the percentage of adult emergence. Additionally, its cytotoxic effects on the digestive cells of midgut, Malpighian tubules cells and Kenyon cells of the brain of newly emerged A...
June 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28680878/at-term-xmo-and-xpo-mouse-placentas-show-differences-in-glucose-metabolism-in-the-trophectoderm-derived-outer-zone
#9
Nannan He, Shujing J Lim, Joana C Moreira de Mello, Injerreau Navarro, Monika Bialecka, Daniela C F Salvatori, Lucette A J van der Westerlaken, Lygia V Pereira, Susana M Chuva de Sousa Lopes
Genetic mouse model (39,XO) for human Turner Syndrome (45,XO) harboring either a single maternally inherited (Xm) or paternally inherited (Xp) chromosome show a pronounced difference in survival rate at term. However, a detailed comparison of XmO and XpO placentas to explain this difference is lacking. We aimed to investigate the morphological and molecular differences between XmO and XpO term mouse placentas. We observed that XpO placentas at term contained a significantly larger area of glycogen cells (GCs) in their outer zone, compared to XmO, XX, and XY placentas...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28676573/a-role-for-cell-repulsion-during-placental-labyrinth-formation
#10
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2017: Development
https://www.readbyqxmd.com/read/28646272/rhesus-cochlear-and-vestibular-functions-are-preserved-after-inner-ear-injection-of-saline-volume-sufficient-for-gene-therapy-delivery
#11
Chenkai Dai, Mohamed Lehar, Daniel Q Sun, Lani Swarthout Rvt, John P Carey, Tim MacLachlan, Doug Brough, Hinrich Staecker, Alexandra M Della Santina, Timothy E Hullar, Charles C Della Santina
Sensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome...
June 23, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28637417/effect-of-heteropterys-aphrodisiaca-on-anxiety-and-male-exposure-of-female-mice-with-advanced-age
#12
Daniela Miranda Farias, Maria Silvia Ostetto, Rozimeri Colleti, Thais Barbosa, Jorge Aparecido Barros, Sergio Machado, Eric Murillo-Rodríguez, Susana E Moreno, André Barciela Veras
BACKGROUND: Effect of Heteropterys aphrodisiac (dog-node) on anxiety and function Of adult female wistar mice. The Project is an experiment with the use of Of H. aphrodisiac root extract, in order to observe the frequency of Sexual exposure of females exposed to the extract, quantify the effect of the extract on the Concentration of total testosterone and observe the anxiety levels of the animals Exposed. Results will be measured with the laboratory testosterone test and LCE and CA tests...
June 21, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28631523/the-association-among-prematurity-cochlear-hyperintensity-and-hearing-loss
#13
Michael A Wien, Matthew T Whitehead
Background Prematurity is a major risk factor for neonatal hearing loss. Recent advancements in magnetic resonance imaging (MRI) have made it possible to evaluate structural details of the membranous labyrinths in premature infants that have heretofore been inaccessible. Objective We compared the prevalence of abnormal cochlear signal intensity in premature and term neonates and evaluated for a potential link with hearing loss. Materials and methods We retrospectively reviewed 148 consecutive MR exams performed in premature (< 37 weeks' gestation) and term neonates performed over a 30-month period...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28627985/diagnostic-performance-of-reformatted-isotropic-thin-section-helical-ct-images-in-the-detection-of-superior-semicircular-canal-dehiscence
#14
Gianvincenzo Sparacia, Alberto Iaia
Purpose The purpose of this article is to assess the diagnostic performance of computed tomography (CT) reformatted images for detection of superior semicircular canal (SSC) dehiscence. Material and methods Forty-two patients, with sound- and/or pressure-induced vestibular symptoms, and 42 control participants underwent helical CT examination with a highly collimated beam (0.5 mm). Reformatted images of the vestibular labyrinth were obtained in the standard axial and coronal planes (group A images), and in a plane parallel and perpendicular to the SSC (group B images)...
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28627704/matrix-metalloproteinase-2-and-9-contribute-to-functional-integrity-and-noise%C3%A2-induced-damage-to-the-blood-labyrinth-barrier
#15
Jun Wu, Weiju Han, Xingrui Chen, Weiwei Guo, Ke Liu, Ruoya Wang, Jishuai Zhang, Na Sai
The cochlear blood-labyrinth barrier (BLB), located in the stria vascularis, is critical for the homeostasis of cochlear solutes and ion transport. Significant disruption to the BLB occurs early during noise‑induced hearing loss. Matrix metalloproteinase (MMP)‑2 and ‑9 are important molecules known to be capable of degrading tight junction (TJ) proteins. The TJ proteins are important components of the extracellular matrix (ECM), required to maintain BLB integrity and permeability. Previous studies have demonstrated that MMP‑2 and ‑9, rich in healthy cochlea, serve an essential role in regulating the cochlear response to acoustic trauma...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625158/a-minimally-invasive-method-for-sampling-human-petrous-bones-from-the-cranial-base-for-ancient-dna-analysis
#16
Kendra A Sirak, Daniel M Fernandes, Olivia Cheronet, Mario Novak, Beatriz Gamarra, Tímea Balassa, Zsolt Bernert, Andrea Cséki, János Dani, József Zsolt Gallina, Gábor Kocsis-Buruzs, Ivett Kővári, Orsolya László, Ildikó Pap, Róbert Patay, Zsolt Petkes, Gergely Szenthe, Tamás Szeniczey, Tamás Hajdu, Ron Pinhasi
Ancient DNA (aDNA) research involves invasive and destructive sampling procedures that are often incompatible with anthropological, anatomical, and bioarcheological analyses requiring intact skeletal remains. The osseous labyrinth inside the petrous bone has been shown to yield higher amounts of endogenous DNA than any other skeletal element; however, accessing this labyrinth in cases of a complete or reconstructed skull involves causing major structural damage to the cranial vault or base. Here, we describe a novel cranial base drilling method (CBDM) for accessing the osseous labyrinth from the cranial base that prevents damaging the surrounding cranial features, making it highly complementary to morphological analyses...
June 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28623973/dynamic-maternal-and-fetal-notch-activity-and-expression-in-placentation
#17
Heather I Levin, Chantae S Sullivan-Pyke, Virginia E Papaioannou, Ronald J Wapner, Jan K Kitajewski, Carrie J Shawber, Nataki C Douglas
INTRODUCTION: Murine placentation requires trophoblast Notch2, while the Notch ligand, JAGGED1, is reduced in invasive trophoblasts from women with preeclampsia. However, the placental cells with active Notch signaling and expression of other Notch proteins and ligands in placentation have yet to be defined. We sought to identify endothelial cell and trophoblast subtypes with canonical Notch signaling in the decidua and placenta and correlate this to expression of Notch proteins and ligands...
July 2017: Placenta
https://www.readbyqxmd.com/read/28623972/placentation-in-the-colugos-cynocephalus-volans-and-galeopterus-variegatus-dermoptera-and-the-transition-from-labyrinthine-to-villous-placentation-in-primates
#18
A M Carter, A M Mess
INTRODUCTION: Phylogenetics and genomics place colugos as the sister group to primates. Therefore their placentation is of interest in an evolutionary perspective. Previous accounts are fragmentary, not readily accessible and sometimes contradictory. METHODS: We have examined archival material covering the early development of fetal membranes and placenta, the fate of the yolk sac and definitive placentation. RESULTS: Initially the trophoblast extended over a rather broad but shallow area, enclosing maternal blood spaces...
July 2017: Placenta
https://www.readbyqxmd.com/read/28618463/diffusion-driven-self-assembly-of-rodlike-particles-monte-carlo-simulation-on-a-square-lattice
#19
Nikolai I Lebovka, Yuri Yu Tarasevich, Volodymyr A Gigiberiya, Nikolai V Vygornitskii
The diffusion-driven self-assembly of rodlike particles was studied by means of Monte Carlo simulation. The rods were represented as linear k-mers (i.e., particles occupying k adjacent sites). In the initial state, they were deposited onto a two-dimensional square lattice of size L×L up to the jamming concentration using a random sequential adsorption algorithm. The size of the lattice, L, was varied from 128 to 2048, and periodic boundary conditions were applied along both x and y axes, while the length of the k-mers (determining the aspect ratio) was varied from 2 to 12...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28602653/infrasonic-and-ultrasonic-hearing-evolved-after-the-emergence-of-modern-whales
#20
Mickaël J Mourlam, Maeva J Orliac
Mysticeti (baleen whales) and Odontoceti (toothed whales) today greatly differ in their hearing abilities: Mysticeti are presumed to be sensitive to infrasonic noises [1-3], whereas Odontoceti are sensitive to ultrasonic sounds [4-6]. Two competing hypotheses exist regarding the attainment of hearing abilities in modern whales: ancestral low-frequency sensitivity [7-13] or ancestral high-frequency sensitivity [14, 15]. The significance of these evolutionary scenarios is limited by the undersampling of both early-diverging cetaceans (archaeocetes) and terrestrial hoofed relatives of cetaceans (non-cetacean artiodactyls)...
June 19, 2017: Current Biology: CB
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