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Total skin electron beam therapy

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https://www.readbyqxmd.com/read/27692530/total-skin-electron-beam-therapy-in-the-treatment-of-mycosis-fungoides-a-review-of-conventional-and-low-dose-regimens
#1
REVIEW
Mudit Chowdhary, Arpit M Chhabra, Shivam Kharod, Gaurav Marwaha
Mycosis fungoides (MF) is the most prevalent subtype of cutaneous T-cell lymphoma, which is characterized by the proliferation of CD4(+) T cells. While often an indolent disease, most patients eventually develop progression from isolated patches to tumors and finally nodal or visceral involvement. Treatment choice is largely based on disease burden, though prognostic factors such as disease stage, patient age, and extracutaneous involvement must be taken into consideration. Radiotherapy represents one of the most effective therapeutic modalities in the treatment of MF...
December 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27531242/loss-of-cd30-expression-after-treatment-with-brentuximab-vedotin-in-a-patient-with-anaplastic-large-cell-lymphoma-a-novel-finding
#2
Rami N Al-Rohil, Carlos A Torres-Cabala, Anisha Patel, Michael T Tetzlaff, Doina Ivan, Priyadharsini Nagarajan, Jonathan L Curry, Roberto N Miranda, Madeleine Duvic, Victor G Prieto, Phyu P Aung
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma characterized by strong and uniform expression of CD30. Brentuximab vedotin (BV), an anti-CD30 antibody-drug conjugate has been approved by the U.S. FDA for relapsed/refractory systemic ALCL and achieves improved outcomes. We report a 44-year-old African-American man who presented with lymphadenopathy, lip and chest nodules diagnosed as CD30+, ALK-negative ALCL. The patient was treated with BV upon recurrence. While on treatment, the patient developed new-onset nodules on the chest and back...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27170936/polydactylous-longitudinal-melanonychia-acquired-following-total-skin-electron-beam-radiation-therapy-for-s%C3%A3-zary-syndrome
#3
Filiberto Cedeno-Laurent, Ellen J Kim, Alain H Rook, Carmela C Vittorio, Adam I Rubin
No abstract text is available yet for this article.
September 2015: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27151889/how-i-treat-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#4
Sean Whittaker, Richard Hoppe, H Miles Prince
Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma variant and is closely related to a rare leukemic variant, Sézary syndrome (SS). MF patients at risk of disease progression can now be identified and an international consortium has been established to address the prognostic relevance of specific biologic factors and define a prognostic index. There are a lack of randomized clinical trial data in MF/SS and evidence is based on a traditional "stage-based" approach; treatment of early-stage disease (IA-IIA) involves skin directed therapies which include topical corticosteroids, phototherapy (psoralen with UVA or UVB), topical chemotherapy, topical bexarotene, and radiotherapy including total skin electron beam therapy...
June 23, 2016: Blood
https://www.readbyqxmd.com/read/26843259/cherenkov-imaging-method-for-rapid-optimization-of-clinical-treatment-geometry-in-total-skin-electron-beam-therapy
#5
Jacqueline M Andreozzi, Rongxiao Zhang, David J Gladstone, Benjamin B Williams, Adam K Glaser, Brian W Pogue, Lesley A Jarvis
PURPOSE: A method was developed utilizing Cherenkov imaging for rapid and thorough determination of the two gantry angles that produce the most uniform treatment plane during dual-field total skin electron beam therapy (TSET). METHODS: Cherenkov imaging was implemented to gather 2D measurements of relative surface dose from 6 MeV electron beams on a white polyethylene sheet. An intensified charge-coupled device camera time-gated to the Linac was used for Cherenkov emission imaging at sixty-two different gantry angles (1° increments, from 239...
February 2016: Medical Physics
https://www.readbyqxmd.com/read/26581145/total-skin-electron-beam-for-primary-cutaneous-t-cell-lymphoma
#6
Khaled Elsayad, Jan Kriz, Christos Moustakis, Sergiu Scobioala, Gabriele Reinartz, Uwe Haverkamp, Normann Willich, Carsten Weishaupt, Rudolf Stadler, Cord Sunderkötter, Hans Theodor Eich
PURPOSE: Recent trials with low-dose total skin electron beam (TSEB) therapy demonstrated encouraging results for treating primary cutaneous T-cell lymphoma (PCTCL). In this study, we assessed the feasibility of different radiation doses and estimated survival rates of different pathologic entities and stages. METHODS AND MATERIALS: We retrospectively identified 45 patients with PCTCL undergoing TSEB therapy between 2000 and 2015. Clinical characteristics, treatment outcomes, and toxicity were assessed...
December 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26299651/erythrodermic-mycosis-fungoides-and-s%C3%A3-zary-syndrome-treated-with-extracorporeal-photopheresis-as-part-of-a-multimodality-regimen-a-single-centre-experience
#7
L Atzmony, I Amitay-Laish, R Gurion, Y Shahal-Zimra, E Hodak
BACKGROUND: Extracorporeal photopheresis (ECP) is recommended for the erythrodermic mycosis fungoides (MF) and Sezary syndrome (SS) alone or in combination with other therapies. The possibility of a differential response in the blood and skin has hardly been addressed in the literature. OBJECTIVES: To evaluate the clinical response rate of patients with erythrodermic MF and SS to ECP as part of a multimodality approach and to compare the kinetics of the blood and skin responses in the presence of leukaemic involvement...
December 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26224888/hypofractionated-electron-beam-radiation-therapy-for-keloids-retrospective-study-of-568-cases-with-834-lesions
#8
Jie Shen, Xin Lian, Yuliang Sun, Xiaojun Wang, Ke Hu, Xiaorong Hou, Shuai Sun, Junfang Yan, Lang Yu, Xiansong Sun, Wenbo Li, Xinhai Wang, Qiu Guan, Tingtian Pang, Fuquan Zhang
We aimed to analyze the outcomes of hypofractionated high-energy electron beam radiotherapy for the treatment of keloids. From February 1998 to January 2012, 568 patients with a total of 834 keloids underwent radiotherapy: 826 lesions with postoperative radiotherapy, and 36 with skin-grafting. Lesion size was >5 cm in 335 keloids. An electron-beam of 6 or 7 MeV was used, with a total dose of 18 Gy (two fractions with a 1-week interval) covering the lesion with a 1-cm margin. The time between surgery and radiotherapy was 24-48 h...
September 2015: Journal of Radiation Research
https://www.readbyqxmd.com/read/26181423/successful-treatment-with-total-skin-electron-beam-therapy-in-a-child-with-isolated-cutaneous-relapsed-aml
#9
Deniz Yilmaz Karapinar, Serra A Kamer, Nihal Karadaş, Yavuz Anacak, Buket E Delcastello, Can Balkan, Kaan Kavakli, Yeşim Aydinok
A 9-year-old girl diagnosed with acute myeloblastic leukemia M4 developed isolated cutaneous relapse. She was given chemotherapy including idarubicin, fludarabine, and cytarabine. Although she developed very severe pancytopenia, increase in the number and size of the lesions was seen. Total skin electron beam therapy was applied to the skin lesions for a total of 18 Gy. All lesions responded to total skin electron beam therapy, some of them completely disappeared. After resolution of the skin findings, she underwent bone marrow transplantation from her matched brother...
August 2015: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26170695/rapidly-progressive-stage-ivb-mycosis-fungoides-treated-with-low-dose-total-skin-electron-beam-therapy
#10
Mudit Chowdhary, Ahmad A Kabbani, Parin Rimtepathip, David A Cole, David J Cohen
Mycosis fungoides (MF) is the most common subtype of primary cutaneous T-cell lymphoma. Normally, MF has an indolent course although patients can progress to an advanced disease state (stages IIB-IVB). Advanced-stage disease is typically aggressive, leaving patients with debilitating symptoms and a decreased quality of life. Moreover, advanced-stage MF often proves refractory to therapy and carries a very poor prognosis. Total skin electron beam (TSEB) therapy is a well-established and successful treatment for early stage MF; however, its efficacy dramatically decreases with advanced-stage disease...
2015: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26128970/tu-ef-304-10-efficient-multiscale-simulation-of-the-proton-relative-biological-effectiveness-rbe-for-dna-double-strand-break-dsb-induction-and-bio-effective-dose-in-the-fluka-monte-carlo-radiation-transport-code
#11
V Moskvin, R Stewart, P Tsiamas, M Axente, J Farr
PURPOSE: One of the more critical initiating events for reproductive cell death is the creation of a DNA double strand break (DSB). In this study, we present a computationally efficient way to determine spatial variations in the relative biological effectiveness (RBE) of proton therapy beams within the FLUKA Monte Carlo (MC) code. METHODS: We used the independently tested Monte Carlo Damage Simulation (MCDS) developed by Stewart and colleagues (Radiat. Res. 176, 587-602 2011) to estimate the RBE for DSB induction of monoenergetic protons, tritium, deuterium, hellium-3, hellium-4 ions and delta-electrons...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128578/mo-ab-bra-08-rapid-treatment-field-uniformity-optimization-for-total-skin-electron-beam-therapy-using-cherenkov-imaging
#12
J Andreozzi, L Jarvis, R Zhang, B Williams, A Glaser, B Pogue, D Gladstone
PURPOSE: To evaluate treatment field heterogeneity resulting from gantry angle choice in total skin electron beam therapy (TSEBT) following a modified Stanford dual-field technique, and determine a relationship between source to surface distance (SSD) and optimized gantry angle spread. METHODS: Cherenkov imaging was used to image 62 treatment fields on a sheet of 1.2m x 2.2m x 1.2cm polyethylene following standard TSEBT setup at our institution (6 MeV, 888 MU/min, no spoiler, SSD=441cm), where gantry angles spanned from 239...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26127855/su-e-t-191-commissioning-and-dosimetric-characteristics-of-elekta-agility-for-total-skin-electron-beam-tseb-therapy
#13
E Sayler, P Charpentier, B Micaily, C Miyamoto, S Li
PURPOSE: The purpose of this work is to publish beam data from Elekta Synergy(R) linear accelerators with Agility(TM) MLC for total skin electron beam (TSEB) therapy using the HDRE1 (High Dose Rate Electron 6MeV) energy. METHOD & MATERIALS: The optimal gantry angles for TSEB were determined using ion chamber measurements along a vertical profile at 450cm SSD. After gantry angles were chosen, field uniformity was measured over the entire treatment area. Uniformity was measured with and without the patient support device, allowing the dosimetric effect of the support device to be determined...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26118544/early-versus-delayed-postoperative-radiotherapy-for-treatment-of-low-grade-gliomas
#14
REVIEW
J Manuel Sarmiento, Andrew S Venteicher, Chirag G Patil
BACKGROUND: In most people with low-grade gliomas (LGG), the primary treatment regimen remains a combination of surgery followed by postoperative radiotherapy. However, the optimal timing of radiotherapy is controversial. It is unclear whether to use radiotherapy in the early postoperative period, or whether radiotherapy should be delayed until tumour progression occurs. OBJECTIVES: To assess the effects of early postoperative radiotherapy versus radiotherapy delayed until tumour progression for low-grade intracranial gliomas in people who had initial biopsy or surgical resection...
June 29, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26103171/moving-gantry-method-for-electron-beam-dose-profile-measurement-at-extended-source-to-surface-distances
#15
Gábor Fekete, Emese Fodor, Csilla Pesznyák
A novel method has been put forward for very large electron beam profile measurement. With this method, absorbed dose profiles can be measured at any depth in a solid phantom for total skin electron therapy. Electron beam dose profiles were collected with two different methods. Profile measurements were performed at 0.2 and 1.2 cm depths with a parallel plate and a thimble chamber, respectively. 108cm × 108 cm and 45 cm × 45 cm projected size electron beams were scanned by vertically moving phantom and detector at 300 cm source-to-surface distance with 90° and 270° gantry angles...
2015: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/25863761/low-dose-10-gy-total-skin-electron-beam-therapy-for-cutaneous-t-cell-lymphoma-an-open-clinical-study-and-pooled-data-analysis
#16
Maria R Kamstrup, Robert Gniadecki, Lars Iversen, Lone Skov, Peter Meidahl Petersen, Annika Loft, Lena Specht
PURPOSE: Cutaneous T-cell lymphomas (CTCLs) are dominated by mycosis fungoides (MF) and Sézary syndrome (SS), and durable disease control is a therapeutic challenge. Standard total skin electron beam therapy (TSEBT) is an effective skin-directed therapy, but the possibility of retreatments is limited to 2 to 3 courses in a lifetime due to skin toxicity. This study aimed to determine the clinical effect of low-dose TSEBT in patients with MF and SS. METHODS AND MATERIALS: In an open clinical study, 21 patients with MF/SS stages IB to IV were treated with low-dose TSEBT over <2...
May 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25775838/-radiation-induced-reactions-in-breast-cancer-patients-after-breast-conserving-surgery-with-intraoperative-and-external-beam-radiotherapy
#17
L I Musabaeva, V A Lisin, V V Velikaia
The present study is aimed to evaluate the frequency and severity of radiation-induced reactions in patients with stage T1-2N0-1M0 breast cancer, who received intraopeartive radiation therapy (IORT) in combination with external beam radiotherapy (EBRT). A small-size betatron producing 6 MeV electron beam was used for IORT. External beam radiotherapy was performed using Rokus and Theratron machines. Radiotherapy treatment was planned using a specially devised method to ensure acceptable levels of severity and frequency of radiation reactions...
September 2014: Radiatsionnaia Biologiia, Radioecologiia
https://www.readbyqxmd.com/read/25761213/comparative-dosimetry-study-of-three-uk-centres-implementing-total-skin-electron-treatment-through-external-audit
#18
MULTICENTER STUDY
S Misson-Yates, R Gonzalez, M McGovern, A Greener
OBJECTIVE: This article describes the external audit measurements conducted in two UK centres implementing total skin electron beam therapy (TSEBT) and the results obtained. METHODS: Measurements of output, energy, beam flatness and symmetry at a standard distance (95 or 100 cm SSD) were performed using a parallel plate chamber in solid water. Similarly, output and energy measurements were also performed at the treatment plane for single and dual fields. Clinical simulations were carried out using thermoluminescent dosemeters (TLDs) and Gafchromic® film (International Specialty Products, Wayne, NJ) on an anthropomorphic phantom...
May 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/25579524/clinical-and-cosmetic-results-of-breast-boost-radiotherapy-in-early-breast-cancer-a-randomized-study-between-electron-and-photon
#19
RANDOMIZED CONTROLLED TRIAL
Soumiya Sampath Rajan, Suresh Chander Sharma, Narendra Kumar, Ritesh Kumar, Gurpreet Singh, Rajender Singh, Parsee Tomar
INTRODUCTION: Breast-conserving surgery followed by radiation therapy (RT) to the intact breast is now clearly established as the most acceptable strategy for women with early-stage invasive breast cancer. Recommended techniques for radiotherapy is whole breast irradiation (WBI) followed by boost to the tumor bed. AIMS: The aim of this study is to compare the modalities of three-dimensional conformal RT (3DCRT) and electron beam therapy as boost in post-lumpectomy patients of early stage breast cancer, following WBI...
October 2014: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/25493522/evaluation-of-treatment-plans-using-various-treatment-techniques-for-the-radiotherapy-of-cutaneous-kaposi-s-sarcoma-developed-on-the-skin-of-feet
#20
Jong Min Park, Il Han Kim, Sung-Joon Ye, Kyubo Kim
The purpose of this study was to investigate the plan qualities of various treatment modalities for the radiotherapy of cutaneous Kaposi's sarcoma developed on the skin of the foot. A total of six virtual targets were generated on the skin of the foot in CT images. Five types of treatment plans were generated using photon beams (PB), electron beams (EB), high-dose-rate (HDR) brachytherapy with a Freiburg flap applicator, intensity-modulated radiation therapy (IMRT), and volumetric- modulated arc therapy (VMAT) techniques...
2014: Journal of Applied Clinical Medical Physics
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