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https://www.readbyqxmd.com/read/27908679/skin-surface-brachytherapy-a-survey-of-contemporary-practice-patterns
#1
Anna O Likhacheva, Phillip M Devlin, Shervin M Shirvani, Christopher A Barker, Phillip Beron, Ajay Bhatnagar, Stephen W Doggett, Lawrence Hochman, Charles Hsu, Michael Kasper, Martin Keisch, Subhakar Mutyala, Bradley Prestidge, Silvia Rodriguez Villalba, Vershalee Shukla, Srinath Sundararaman, Mitchell Kamrava
PURPOSE: The aim of this study was to define current patterns of care among radiation oncologists who use skin surface brachytherapy for the treatment of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) in academic and community settings. METHODS AND MATERIALS: A 30-question electronic survey was administered to clinician members of the American Brachytherapy Society. The respondents were asked to provide details regarding their clinical practice and their approach to skin surface brachytherapy...
November 28, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27903347/-clinical-genetic-and-pathological-features-of-neuronal-ceroid-lipofuscinosis-in-5-chinese-patients
#2
S C Ren, B Q Gao, Y J Wang, X J Wu, Z X Tian, Y L Sun
Objective: To report the clinical, genetic and ultrastructural pathological features of neuronal ceroid lipofuscinosis (NCLs) in 5 Chinese patients. Methods: A total of 5 patients with NCLs were collected from 2013 to 2015 diagnosed by the department of pediatrics of Beijing Tian Tan Hospital. Their clinical, electrophysiological and neuroimaging data of the patients were reviewed.A total of 9 underlying genes of NCLs were tested in 4 cases and their parents.Ultrastructural pathology by skin biopsy was performed in 3 cases respectively...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27898140/ny-subtyp-av-molluscipoxvirus-p%C3%A3-visad-modern-teknik-identifierar-nya-och-ovanliga-patogener-snabbare
#3
Anna-Lena Hammarin, Yvonne Eklund, Maria Karlberg, Morten Bogh, Per Sikora
Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. The patient was presented with a fairly smooth nodule of 2 cm in diameter on the ring finger. Molluscipoxvirus-like virus particles were detected by electron microscopy from the nodule, but since the clinical picture was not compatible with MC, next generation sequencing was performed in order to verify the diagnosis...
November 28, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27892996/technique-standards-for-skin-lesion-imaging-a-delphi-consensus-statement
#4
Chinmayee Katragadda, Anna Finnane, H Peter Soyer, Ashfaq A Marghoob, Allan Halpern, Josep Malvehy, Harald Kittler, Rainer Hofmann-Wellenhof, Dennis Da Silva, Ivo Abraham, Clara Curiel-Lewandrowski
Importance: Variability in the metrics for image acquisition at the total body, regional, close-up, and dermoscopic levels impacts the quality and generalizability of skin images. Consensus guidelines are indicated to achieve universal imaging standards in dermatology. Objective: To achieve consensus among members of the International Skin Imaging Collaboration (ISIC) on standards for image acquisition metrics using a hybrid Delphi method. Evidence Review: Delphi study with 5 rounds of ratings and revisions until relative consensus was achieved...
November 23, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27888034/a-proactive-approach-to-penicillin-allergy-testing-in-hospitalized-patients
#5
Justin R Chen, Scott A Tarver, Kristin S Alvarez, Trang Tran, David A Khan
BACKGROUND: Penicillin allergy testing is underutilized in inpatients despite its potential to immediately impact antibiotic treatment. Although most tested patients are able to tolerate penicillin, limited availability and awareness of this tool leads to the use of costly and harmful substitutes. OBJECTIVE: We established an inpatient service at a large academic hospital to identify and test patients with a history of penicillin allergy with the goals of removing inaccurate diagnoses, reducing the use of beta-lactam alternatives, and educating patients and clinicians about the procedure...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27881826/a-soft-wearable-microfluidic-device-for-the-capture-storage-and-colorimetric-sensing-of-sweat
#6
Ahyeon Koh, Daeshik Kang, Yeguang Xue, Seungmin Lee, Rafal M Pielak, Jeonghyun Kim, Taehwan Hwang, Seunghwan Min, Anthony Banks, Philippe Bastien, Megan C Manco, Liang Wang, Kaitlyn R Ammann, Kyung-In Jang, Phillip Won, Seungyong Han, Roozbeh Ghaffari, Ungyu Paik, Marvin J Slepian, Guive Balooch, Yonggang Huang, John A Rogers
Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27877065/poor-adhesion-of-fentanyl-transdermal-patches-may-mimic-end-of-dosage-failure-after-48-hours-and-prompt-early-patch-replacement-in-hospitalized-cancer-pain-patients
#7
Isabelle Arnet, Sabrina Schacher, Eva Balmer, Dieter Koeberle, Kurt E Hersberger
CONTEXT: Renewal of fentanyl transdermal patch (transdermal therapeutic system [TTS]) should occur every 3 days (72 hours) according to manufacturer's guidelines. Some studies mentioned patients reporting end-of-dose failure, and thus, some authors recommend shortening the interval of application to 2 days (48 hours). However, reasons for early replacement are mostly unknown. OBJECTIVES: The objectives of this study were to assess the prevalence of early replacement of fentanyl TTS in a cancer center in Basel, Switzerland, and to assess the reasons for early replacement in stationary patients...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27855652/performance-of-an-electronic-health-record-based-phenotype-algorithm-to-identify-community-associated-methicillin-resistant-staphylococcus-aureus-cases-and-controls-for-genetic-association-studies
#8
Kathryn L Jackson, Michael Mbagwu, Jennifer A Pacheco, Abigail S Baldridge, Daniel J Viox, James G Linneman, Sanjay K Shukla, Peggy L Peissig, Kenneth M Borthwick, David A Carrell, Suzette J Bielinski, Jacqueline C Kirby, Joshua C Denny, Frank D Mentch, Lyam M Vazquez, Laura J Rasmussen-Torvik, Abel N Kho
BACKGROUND: Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the most common causes of skin and soft tissue infections in the United States, and a variety of genetic host factors are suspected to be risk factors for recurrent infection. Based on the CDC definition, we have developed and validated an electronic health record (EHR) based CA-MRSA phenotype algorithm utilizing both structured and unstructured data. METHODS: The algorithm was validated at three eMERGE consortium sites, and positive predictive value, negative predictive value and sensitivity, were calculated...
November 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27843971/cold-burn-injuries-in-the-uk-the-11-year-experience-of-a-tertiary-burns-centre
#9
Metin Nizamoglu, Alethea Tan, Tobias Vickers, Nicholas Segaren, David Barnes, Peter Dziewulski
BACKGROUND: Guidance for the management of thermal injuries has evolved with improved understanding of burn pathophysiology. Guidance for the management of cold burn injuries is not widely available. The management of these burns differs from the standard management of thermal injuries. This study aimed to review the etiology and management of all cold burns presenting to a large regional burn centre in the UK and to provide a simplified management pathway for cold burns. METHODS: An 11-year retrospective  analysis (1 January 2003-31 December 2014)  of all cold injuries presenting to a regional burns centre in the UK was conducted...
2016: Burns and trauma
https://www.readbyqxmd.com/read/27843335/incidence-of-clinical-symptoms-during-long-duration-orbital-spaceflight
#10
Brian Crucian, Adriana Babiak-Vazquez, Smith Johnston, Duane L Pierson, C Mark Ott, Clarence Sams
BACKGROUND: The environment of spaceflight may elevate an astronaut's clinical risk for specific diseases. The purpose of this study was to derive, as accurately as currently possible, an assessment of in-flight clinical "incidence" data, based on observed clinical symptoms in astronauts on board the International Space Station (ISS). METHODS: Electronic medical records were examined from 46 long-duration ISS crew members, each serving approximately a 6-month mission on board the ISS, constituting 20...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27825918/combination-of-grape-extract-silver-nanoparticles-and-liposomes-a-totally-green-approach
#11
Ines Castangia, Francesca Marongiu, Maria Letizia Manca, Raffaello Pompei, Fabrizio Angius, Andrea Ardu, Anna Maria Fadda, Maria Manconi, Guido Ennas
In the present work, silver nanoparticles were prepared using a totally green procedure combining silver nitrate and an extract of grape pomace as a green source. Additionally, nanoparticles were stabilized using phospholipid and water and/or a mixture of water and propylene glycol (PG). To the best of our knowledge, grape-silver nanoparticle stabilized liposomes or PG-liposomes were formulated, for the first time, combining the residual products of wine-made industry, silver nitrate and phospholipids, avoiding the addition of hazardous substances to human health and the environment, in an easy, scalable and reproducible method...
November 4, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27792802/assessment-of-mechanical-pain-thresholds-in-the-orofacial-region-a-comparison-between-pinprick-stimulators-and-electronic-von-frey-device
#12
Kayo Suzuki, Lene Baad-Hansen, Maria Pigg, Peter Svensson
AIMS: To compare mechanical pain thresholds (MPTs) in the orofacial region assessed with two different approaches: with an electronic von Frey (EvF) device and with custom-made weighted pinprick stimulators. The test-retest reliability, variability of MPTs, and time duration of each test were also compared, as well as the ability of each test to create stimulus-response (S-R) curves. METHODS: A total of 16 healthy volunteers participated. The MPT and S-R curve measurements were done with the two different techniques at three sites: on the skin of the right cheek (face), on the buccal gingival mucosa of the right upper premolar region (gingiva), and on the tip of the tongue (tongue)...
October 2016: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/27784001/clinical-application-of-3d-printed-step-bolus-in-post-total-mastectomy-electron-conformal-therapy
#13
Kwangwoo Park, Sungjin Park, Mi-Jin Jeon, Jinhyun Choi, Jun Won Kim, Yoon Jin Cho, Won-Seok Jang, Yo Sup Keum, Ik Jae Lee
The 3D-printed boluses were used during the radiation therapy of the chest wall in six patients with breast cancer after modified radical mastectomy (MRM). We measured the in-vivo skin doses while both conventional and 3D-printed boluses were placed on the chest wall and compared the mean doses delivered to the ipsilateral lung and the heart. The homogeneity and conformity of the dose distribution in the chest wall for both types of boluses were also evaluated. The uniformity index on the chest skin was improved when the 3D-printed boluses were used, with the overall average skin dose being closer to the prescribed one in the former case (-0...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27778435/safety-and-efficacy-of-topical-ketoprofen-in-transfersome-gel-in-knee-osteoarthritis-a-systematic-review
#14
Vandit Sardana, Joanna Burzynski, Paul Zalzal
PURPOSE: Topical ketoprofen in Transfersome gel has been used for the alleviation of symptoms in osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with various side effects. Topical NSAIDs are known to have a lower side-effect profile when compared with systemic administration. The present systematic review aimed to determine the safety and efficacy of topical ketoprofen in Transfersome gel in knee osteoarthritis (OA). METHODS: A systematic literature review was performed...
October 24, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27773801/a-review-of-ethnobotany-therapeutic-value-phytochemistry-and-pharmacology-of-crinum-macowanii-baker-a-highly-traded-bulbous-plant-in-southern-africa
#15
Alfred Maroyi
ETHNOPHARMACOLOGICAL RELEVANCE: Crinum macowanii is a deciduous bulbous plant which grows in east, central and southern Africa. Crinum macowanii has been used as herbal medicine by the indigenous people of east and southern Africa has for several centuries. The bulb, leaves and roots of C. macowanii are reported to possess diverse medicinal properties and used to treat or manage various human and animal diseases and ailments throughout its distributional range. Crinum macowanii is used traditionally as a remedy for boils, diarrhoea, fever, inflammation, respiratory system problems, skin rashes, tuberculosis, wounds and urinary tract problems...
October 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27757740/design-and-%C3%AE-testing-of-an-electronic-rounding-tool-certainp-to-improve-process-of-care-in-pediatric-intensive-care-unit
#16
Manasi Hulyalkar, Stephen J Gleich, Rahul Kashyap, Amelia Barwise, Harsheen Kaur, Yue Dong, Lei Fan, Srinivas Murthy, Grace M Arteaga, Sandeep Tripathi
Increasing process complexity in the pediatric intensive care unit (PICU) can lead to information overload resulting in missing pertinent information and potential errors during morning rounds. An efficient model using a novel electronic rounding tool was designed as part of a broader critical care decision support system-checklist for early recognition and treatment of acute illness and injury in pediatrics (CERTAINp). We aimed to evaluate its impact on improving the process of care during rounding. Prospective pre- and post-interventional data included: team performance baseline assessment, patient safety discussion, guideline adherence, rounding time, and a survey of Residents' and Nurses' perception using a Likert scale...
October 18, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27747899/safety-and-efficacy-of-outpatient-parenteral-antibiotic-therapy-in-an-academic-infectious-disease-clinic
#17
G Suleyman, R Kenney, M J Zervos, A Weinmann
WHAT IS KNOWN AND OBJECTIVE: Outpatient parenteral therapy (OPAT) has become a safe and effective modality for patients requiring intravenous or prolonged antimicrobial therapy since the 1970s. It is being increasingly utilized in various settings; however, studies evaluating the safety and efficacy of clinic-based OPAT are limited. Since 2012, patients being considered for OPAT have required an infectious disease (ID) consultation at our institution. Candidates receiving once-daily antimicrobials who were ineligible for home infusion or nursing home placement as determined by their insurance companies and those who preferred the clinic over nursing home or home infusion were referred to the ID clinic...
October 16, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27716384/ion-channels-expression-and-function-are-strongly-modified-in-solid-tumors-and-vascular-malformations
#18
Antonella Biasiotta, Daniela D'Arcangelo, Francesca Passarelli, Ezio Maria Nicodemi, Antonio Facchiano
BACKGROUND: Several cellular functions relate to ion-channels activity. Physiologically relevant chains of events leading to angiogenesis, cell cycle and different forms of cell death, require transmembrane voltage control. We hypothesized that the unordered angiogenesis occurring in solid cancers and vascular malformations might associate, at least in part, to ion-transport alteration. METHODS: The expression level of several ion-channels was analyzed in human solid tumor biopsies...
October 4, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27692530/total-skin-electron-beam-therapy-in-the-treatment-of-mycosis-fungoides-a-review-of-conventional-and-low-dose-regimens
#19
REVIEW
Mudit Chowdhary, Arpit M Chhabra, Shivam Kharod, Gaurav Marwaha
Mycosis fungoides (MF) is the most prevalent subtype of cutaneous T-cell lymphoma, which is characterized by the proliferation of CD4(+) T cells. While often an indolent disease, most patients eventually develop progression from isolated patches to tumors and finally nodal or visceral involvement. Treatment choice is largely based on disease burden, though prognostic factors such as disease stage, patient age, and extracutaneous involvement must be taken into consideration. Radiotherapy represents one of the most effective therapeutic modalities in the treatment of MF...
December 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27675777/cd4-cd8-ratio-in-mycosis-fungoides-prognostic-and-predictive-value-of-circulating-t-lymphocyte-subsets-for-outcomes-after-total-skin-electron-beam-radiation
#20
W Jiang, Z Abou Yehia, B Dabaja, M Duvic, S A Milgrom, C C Pinnix, Y Oki, N D'Souza, G L Smith
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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