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miRNA systematic review

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https://www.readbyqxmd.com/read/29149908/exosomal-micrornas-as-potential-circulating-biomarkers-in-gastrointestinal-tract-cancers-a-systematic-review-protocol
#1
Elmira Gheytanchi, Zahra Madjd, Leila Janani, Arezoo Rasti, Roya Ghods, Fatemeh Atyabi, Mohammad Hossein Asadi Lari, Sadegh Babashah
BACKGROUND: Metastasis is the most frequent type of recurrence in gastrointestinal (GI) cancers, and there is an emerging potential for new diagnostic and therapeutic approaches, especially in the cases of metastatic GI carcinomas. The expression profiles of circulating exosomal microRNAs are of particular interest as novel non-invasive diagnostic and prognostic biomarkers for improved detection of GI cancers in body fluids, especially in the serum of patients with recurrent cancers. The aim of this study is to systematically review primary studies and identify the miRNA profiles of serum exosomes of GI cancers...
November 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29143228/effect-of-exosome-biomarkers-for-diagnosis-and-prognosis-of-breast-cancer-patients
#2
REVIEW
M Wang, S Ji, G Shao, J Zhang, K Zhao, Z Wang, A Wu
PURPOSE: Exosomes are gradually detected as an indicator for diagnosis and prognosis of breast cancer in clinic and a systematic review was conducted. METHODS: A search for clinical studies published before July 1, 2017 was performed. Methods of exosome purification and identification from all studies were extracted. For diagnosis evaluation, the comparison of exosome biomarkers expression between breast cancer patients and healthy women was obtained; for prognosis prediction, the correlation between exosome biomarkers expression and chemotherapy resistance, overall survival (OS), disease-free survival (DFS), recurrence and metastasis of breast cancer was also extracted...
November 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29128328/circulating-micrornas-as-biomarkers-for-acute-ischemic-stroke-a-systematic-review
#3
Brittany Dewdney, Alexandra Trollope, Joseph Moxon, Diana Thomas Manapurathe, Erik Biros, Jonathan Golledge
BACKGROUND: Acute ischemic stroke is a leading cause of death and disability worldwide. Unlike myocardial infarction, there is no current blood test to diagnose acute ischemic stroke. MicroRNAs (miRNAs) are very stable in the blood and have been suggested as potential diagnostic markers. MATERIALS AND METHODS: This review aimed to systematically assess case-control studies investigating the association of circulating miRNAs with acute ischemic stroke. Medline, CINAHL, Cochrane Library, Web of Science, Scopus, and PubMed were searched for studies that examined the association of circulating miRNAs in patients with acute ischemic stroke...
November 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29104807/neural-vascular-mechanism-for-the-cerebral-blood-flow-autoregulation-after-hemorrhagic-stroke
#4
REVIEW
Ming Xiao, Qiang Li, Hua Feng, Le Zhang, Yujie Chen
During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral perfusion, but secondary dysfunction of cerebral flow autoregulation will eventually reduce global cerebral blood flow and the delivery of metabolic substrates, leading to generalized cerebral ischemia, hypoxia, and ultimately, neuronal cell death. Cerebral blood flow is controlled by various regulatory mechanisms, including prevailing arterial pressure, intracranial pressure, arterial blood gases, neural activity, and metabolic demand...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29101635/candidate-mirnas-in-human-breast-cancer-biomarkers-a-systematic-review
#5
Masoumeh Adhami, Ali Akbar Haghdoost, Balal Sadeghi, Reza Malekpour Afshar
BACKGROUND: Breast cancer (BC) is the most prevalent cancer and the main cause of cancer deaths among females around the world. For early diagnosis of BC, there would be an immediate and essential requirement to search for sensitive biomarkers. METHODS: To identify candidate miRNA biomarkers for BC, we performed a general systematic review regarding the published miRNA profiling researches comparing miRNA expression level between BC and normal tissues. A miRNA ranking system was selected, which considered frequency of comparisons in direction and agreement of differential expression...
November 3, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29077860/systematic-review-of-computational-methods-for-identifying-mirna-mediated-rna-rna-crosstalk
#6
Yongsheng Li, Xiyun Jin, Zishan Wang, Lili Li, Hong Chen, Xiaoyu Lin, Song Yi, Yunpeng Zhang, Juan Xu
Posttranscriptional crosstalk and communication between RNAs yield large regulatory competing endogenous RNA (ceRNA) networks via shared microRNAs (miRNAs), as well as miRNA synergistic networks. The ceRNA crosstalk represents a novel layer of gene regulation that controls both physiological and pathological processes such as development and complex diseases. The rapidly expanding catalogue of ceRNA regulation has provided evidence for exploitation as a general model to predict the ceRNAs in silico. In this article, we first reviewed the current progress of RNA-RNA crosstalk in human complex diseases...
October 25, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29076520/circulating-or-tissue-micrornas-and-extracellular-vesicles-as-potential-lung-cancer-biomarkers-a-systematic-review
#7
Yan Song, Xiuli Yu, Zongmei Zang, Guijuan Zhao
For both lung cancer patients and clinical physicians, tumor biomarkers for more efficient early diagnosis and prediction of prognosis are always wanted. Biomarkers in circulating serum, including microRNAs (miRNAs) and extracellular vesicles, hold the greatest possibilities to partially substitute for tissue biopsy. In this systematic review, studies on circulating or tissue miRNAs and extracellular vesicles as potential biomarkers for lung cancer patients were reviewed and are discussed. Furthermore, the target genes of the miRNAs indicated were identified through the miRTarBase, while the relevant biological processes and pathways of miRNAs in lung cancer were analyzed through MiRNA Enrichment Analysis and Annotation (MiEAA)...
October 24, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29069873/prognostic-value-of-microrna-expression-levels-in-pancreatic-adenocarcinoma-a-review-of-the-literature
#8
REVIEW
Patrick Wald, X Shawn Liu, Cory Pettit, Mary Dillhoff, Andrei Manilchuk, Carl Schmidt, Evan Wuthrick, Wei Chen, Terence M Williams
BACKGROUND: Clinical and pathologic markers of prognosis and patterns of failure help guide clinicians in selecting patients for adjuvant therapy after surgical resection for pancreatic adenocarcinoma (PDAC). Recent studies have reported the prognostic utility of microRNA profiling in numerous malignancies. Here, we review and summarize the current literature regarding associations between microRNA expression and overall survival in PDAC patients. MATERIALS AND METHODS: We conducted a systematic search in the PubMed database to identify all primary research studies reporting prognostic associations between tumor and/or serum microRNA expression and overall survival in PDAC patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29040025/effect-of-chronic-consumption-of-pistachios-pistacia-vera-l-on-glucose-metabolism-in-pre-diabetics-and-type-2-diabetics-a-systematic-review
#9
P V M Ribeiro, A Silva, A P Almeida, H H Hermsdorff, R C Alfenas
Pistachio is a nut with high polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), polyphenols and carotenoids content, and the synergism between these compounds appears to affect glucose metabolism. In this systematic review we analyzed studies in which the effect of chronic consumption of pistachio on markers of glucose metabolism was evaluated in pre-diabetic and type 2 diabetics. We used the PubMed, Scopus, Cochrane and Lilacs databases. The research terms used were pistachio, pre-diabetes, type 2 diabetes mellitus, insulin resistance, blood glucose, hyperglycemia and glycated hemoglobin (HbA1c)...
October 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28990243/micrornas-a-novel-potential-biomarker-for-diagnosis-and-therapy-in-patients-with-non-small-cell-lung-cancer
#10
REVIEW
Qun Zhou, Shao-Xin Huang, Feng Zhang, Shu-Jun Li, Cong Liu, Yong-Yong Xi, Liang Wang, Xin Wang, Qi-Qiang He, Cheng-Cao Sun, De-Jia Li
BACKGROUND: Lung cancer is still one of the most serious causes of cancer-related deaths all over the world. MicroRNAs (miRNAs) are defined as small non-coding RNAs which could play a pivotal role in post-transcriptional regulation of gene expression. Increasing evidence demonstrated dysregulation of miRNA expression associates with the development and progression of NSCLC. AIMS: To emphasize a variety of tissue-specific miRNAs, circulating miRNAs and miRNA-derived exosomes could be used as potential diagnostic and therapeutic biomarkers in NSCLC patients...
October 8, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28986402/microrna-expression-profiles-and-type-1-diabetes-mellitus-systematic-review-and-bioinformatic-analysis
#11
Taís S Assmann, Mariana Recamonde-Mendoza, Bianca M De Souza, Daisy Crispim
Growing evidence indicates that microRNAs (miRNAs) have a key role in processes involved in type 1 diabetes mellitus (T1DM) pathogenesis, including immune system functions and beta-cell metabolism and death. Although dysregulated miRNA profiles have been identified in T1DM patients, results are inconclusive; with only few miRNAs being consistently dysregulated among studies. Thus, we performed a systematic review of the literature on the subject, followed by bioinformatic analysis, to point out which miRNAs are dysregulated in T1DM-related tissues and in which pathways they act...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28978119/systematic-literature-review-and-clinical-validation-of-circulating-micrornas-as-diagnostic-biomarkers-for-colorectal-cancer
#12
Cheng Pan, Xuebing Yan, Hao Li, Linsheng Huang, Mingming Yin, Yongzhi Yang, Renyuan Gao, Leiming Hong, Yanlei Ma, Chenzhang Shi, Huanlong Qin, Peng Zhang
Because patients with colorectal cancer (CRC) are usually diagnosed at an advanced stage and current serum tumor markers have limited diagnostic efficacy, there is an urgent need to identify reliable diagnostic biomarkers. To better define the diagnostic potential of microRNAs (miRNAs) for CRC, we performed a comprehensive evaluation of reported circulating CRC miRNA markers. After a systematic literature review, we selected 30 candidate miRNAs and used quantitative real-time polymerase chain reaction to examine their expression in a training cohort of 120 plasma samples (CRC vs healthy controls (HC) = 60:60)...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969861/the-mirnome-of-bipolar-disorder
#13
REVIEW
Gabriel R Fries, Andre F Carvalho, Joao Quevedo
BACKGROUND: Epigenetic mechanisms have been suggested to play a key role in the pathophysiology of bipolar disorder (BD), among which microRNAs (miRNAs) may be of particular significance according to recent studies. We aimed to summarize miRNA studies in BD to identify consistent findings, limitations, and future directions of this emerging field. METHODS: We performed a comprehensive search on PUBMED and Medline for studies investigating an association between BD and miRNAs...
September 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28968629/systematic-review-regulatory-principles-of-non-coding-rnas-in-cardiovascular-diseases
#14
Yongsheng Li, Caiqin Huo, Tao Pan, Lili Li, Xiyun Jin, Xiaoyu Lin, Juan Chen, Jinwen Zhang, Zheng Guo, Juan Xu, Xia Li
Cardiovascular diseases (CVDs) continue to be a major cause of morbidity and mortality, and non-coding RNAs (ncRNAs) play critical roles in CVDs. With the recent emergence of high-throughput technologies, including small RNA sequencing, investigations of CVDs have been transformed from candidate-based studies into genome-wide undertakings, and a number of ncRNAs in CVDs were discovered in various studies. A comprehensive review of these ncRNAs would be highly valuable for researchers to get a complete picture of the ncRNAs in CVD...
August 16, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28950674/biomarkers-in-tumorigenesis-using-cancer-cell-lines-a-systematic-review
#15
Lizbeth Raju K, Dominic Augustine, Roopa S Rao, Sowmya S V, Vanishri C Haragannavar, Shwetha Nambiar, Kavitha Prasad, Kamran Habib Awan, Shankargouda Patil
Cancer is a leading cause of death worldwide. Despite many research advancements in the field, the genetic changes regulating the transformation of normal oral cells into malignant cells have not been fully elucidated. Several studies have evaluated carcinogenesis at the molecular level. Cancer cell lines are commonly used in biomedical research because they provide an unlimited source of cells and represent various stages of initiation and progression of carcinogenesis in vitro. Aims: The objective of the study was to review original research articles using cancer cell lines as a tool to understand carcinogenesis and to identify the genes involved in tumor development...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28912503/systematic-review-and-meta-analysis-of-differentially-expressed-mirnas-in-experimental-and-human-temporal-lobe-epilepsy
#16
A Korotkov, J D Mills, J A Gorter, E A van Vliet, E Aronica
Temporal lobe epilepsy (TLE) is a common chronic neurological disease in humans. A number of studies have demonstrated differential expression of miRNAs in the hippocampus of humans with TLE and in animal models of experimental epilepsy. However, the dissimilarities in experimental design have led to largely discordant results across these studies. Thus, a comprehensive comparison is required in order to better characterize miRNA profiles obtained in various post-status epilepticus (SE) models. We therefore created a database and performed a meta-analysis of differentially expressed miRNAs across 3 post-SE models of epileptogenesis (electrical stimulation, pilocarpine and kainic acid) and human TLE with hippocampal sclerosis (TLE-HS)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903437/meta-analysis-of-micrornas-expression-in-head-and-neck-cancer-uncovering-association-with-outcome-and-mechanisms
#17
Joshua Lubov, Mariana Maschietto, Iman Ibrahim, Alex Mlynarek, Michael Hier, Luiz Paulo Kowalski, Moulay A Alaoui-Jamali, Sabrina Daniela da Silva
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at advanced stages, incurring significant high mortality and morbidity. This review explored the risk stratification of miRNAs, and investigated the impact of miRNA networking in HNSCC prognostication. We performed a meta-analysis and a systematic literature search on online databases for papers published prior to December 1, 2016. The list of miRNAs was uploaded to MetacoreTM to construct a protein-protein interaction network, which was used to identify targets of the miRNAs and potential drugs...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903436/prognostic-value-of-micrornas-in-gastric-cancer-a-meta-analysis
#18
Yue Zhang, Dong-Hui Guan, Rong-Xiu Bi, Jin Xie, Chuan-Hua Yang, Yue-Hua Jiang
BACKGROUND: Previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of patients with gastric cancer (GC). A systematic review and meta-analysis was performed to study the outcome of it. DESIGN: Meta-analysis. METHODS: English studies estimating expression levels of miRNAs with any of survival curves in GC were identified up till March 19, 2017 through performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews by two authors independently...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28884871/lncrna-atb-an-indispensable-cancer-related-long-noncoding-rna
#19
REVIEW
Jinglin Li, Zhenglong Li, Wangyang Zheng, Xinheng Li, Zhidong Wang, Yunfu Cui, Xingming Jiang
OBJECTIVES: Long non-coding RNAs (lncRNAs) are a group of non-protein-coding RNAs that are greater than 200 nucleotides in length. Increasing evidence indicates that lncRNAs, which may serve as either oncogenes or tumour suppressor genes, play a vital role in the pathophysiology of human diseases, especially in tumourigenesis and progression. Deregulation of lncRNAs impacts different cellular processes, such as proliferation, dedifferentiation, migration, invasion and anti-apoptosis. The aim of this review was to explore the molecular mechanism and clinical significance of long non-coding RNA-activated by transforming growth factor β (lncRNA-ATB) in various types of cancers...
September 8, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28884117/the-role-of-mirnas-as-biomarkers-for-pregnancy-outcomes-a-comprehensive-review
#20
REVIEW
Martina Barchitta, Andrea Maugeri, Annalisa Quattrocchi, Ottavia Agrifoglio, Antonella Agodi
Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure...
2017: International Journal of Genomics
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