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miRNA systematic review

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https://www.readbyqxmd.com/read/27917109/role-of-micrornas-in-the-regulation-of-%C3%AE-synuclein-expression-a-systematic-review
#1
REVIEW
Ariadna Recasens, Celine Perier, Carolyn M Sue
Growing evidence suggests that increased levels of α-synuclein might contribute to the pathogenesis of Parkinson's disease (PD) and therefore, it is crucial to understand the mechanisms underlying α-synuclein expression. Recently, microRNAs (miRNAs) have emerged as key regulators of gene expression involved in several diseases such as PD and other neurodegenerative disorders. A systematic literature search was performed here to identify microRNAs that directly or indirectly impact in α-synuclein expression/accumulation and describe its mechanism of action...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27894413/targeting-of-bcr-abl-lessons-learned-from-bcr-abl-inhibition
#2
X Lin, M Z Qureshi, R Attar, S Khalid, F Tahir, A Yaqub, A Aslam, I Yaylim, L K De Carlos Back, A A Farooqi, M Ismail
In 1960 researchers reported that balanced translocation between chromosomes 22 and 9 resulted in the generation of Philadelphia chromosome. This breakthrough revolutionized our knowledge related to leukemia biology and contemporary studies revealed that chromosomal translocation resulted in the fusion between the 5' segment of BCR gene and 3' segment of the ABL gene to form BCR/ABL fusion gene. Research over the years has progressively and systematically improved our understanding of the genetic and proteomic basis of Leukemia...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27878945/regulatory-non-coding-rnas-in-acute-myocardial-infarction
#3
REVIEW
Yuan Guo, Fei Luo, Qiong Liu, Danyan Xu
Acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that leads to high mortality and morbidity globally. Various therapeutic targets for AMI have been investigated in recent years, including the non-coding RNAs (ncRNAs). NcRNAs, a class of RNA molecules that typically do not code proteins, are divided into several subgroups. Among them, microRNAs (miRNAs) are widely studied for their modulation of several pathological aspects of AMI, including cardiomyocyte apoptosis, inflammation, angiogenesis and fibrosis...
November 23, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27870469/a-panel-of-circulating-mirnas-as-diagnostic-biomarkers-for-screening-multiple-myeloma-a-systematic-review-and-meta-analysis
#4
REVIEW
L Zhang, D Cao, L Tang, C Sun, Y Hu
Circulating microRNAs (miRNAs) have been proved to be effective diagnostic markers for multiple myeloma (MM). The meta-analysis was aimed to evaluate the diagnostic value of related miRNAs. Multiple databases (PubMed, Web of Science, EMBASE, Cochrane Library, CBM, and CNKI) were systematically searched for available studies up to March 2016. All data were analyzed with the help of software revman 5.3 and metadisc 1.4. The eligible articles' quality was estimated by QUADAS-2, and pooled parameters were acquired with the bivariate random-effects meta-analysis model...
December 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27802200/modern-molecular-biomarkers-of-head-and-neck-cancer-part-i-epigenetic-diagnostics-and-prognostics-systematic-review
#5
Gintaras Juodzbalys, David Kasradze, Marco Cicciù, Aurimas Sudeikis, Laurynas Banys, Pablo Galindo-Moreno, Zygimantas Guobis
INTRODUCTION: Nearly half of the head and neck cancer cases are diagnosed in late stages. Traditional screening modalities have many disadvantages. The aim of the present article was to review the scientific literature about novel head and neck cancer diagnostics - epigenetic biomarkers. EVIDENCE ACQUISITION: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in English language published from 2004 to 2015...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27729619/role-of-an-imbalanced-mirnas-axis-in-pathogenesis-of-psoriasis-novel-perspectives-based-on-review-of-the-literature
#6
Mao-Jie Wang, Yong-Yue Xu, Run-Yue Huang, Xiu-Min Chen, Hai-Ming Chen, Ling Han, Yu-Hong Yan, Chuan-Jian Lu
BACKGROUND: Specific profile of microRNAs (miRNAs, miR) expressed in psoriasis has been identified in the past few years, while the studies on roles and molecular mechanisms of these miRNAs are still on the way. In our previous study, four specific miRNAs (miR-31, miR-203, hsa-miR-99a and miR-125b) were found to be specifically altered in psoriatic lesions.We therefore conducted a systematic literature review in this study to reveal the role of these miRNAs in the pathogenesis of psoriasis in order to inform future research...
October 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27685786/animal-models-for-glucocorticoid-induced-postmenopausal-osteoporosis-an-updated-review
#7
Zhida Zhang, Hui Ren, Gengyang Shen, Ting Qiu, De Liang, Zhidong Yang, Zhensong Yao, Jingjing Tang, Xiaobing Jiang, Qiushi Wei
Glucocorticoid-induced postmenopausal osteoporosis is a severe osteoporosis, with high risk of major osteoporotic fractures. This severe osteoporosis urges more extensive and deeper basic study, in which suitable animal models are indispensable. However, no relevant review is available introducing this model systematically. Based on the recent studies on GI-PMOP, this brief review introduces the GI-PMOP animal model in terms of its establishment, evaluation of bone mass and discuss its molecular mechanism. Rat, rabbit and sheep with their respective merits were chosen...
September 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27666518/micrornas-involved-in-parkinson-s-disease-a-systematic-review
#8
Franciele Cascaes da Silva, Rodrigo da Rosa Iop, Giovanna Grunewald Vietta, Diego Alessandro Kair, Paulo José Barbosa Gutierres Filho, José Gustavo Souza de Alvarenga, Rudney da Silva
The aim of the present study was to determine the expression of blood microRNAs (miRNAs) involved in PD in humans. For this purpose the following electronic databases were selected: MEDLINE by Pubmed, Scopus and Web of Science. The search strategy included the proposed descriptors in the Medical Subject Headings. There were no restrictions with respect to the language of the publication. In the study selection two independent reviewers initially evaluated studies that were identified by the search strategy according to titles and abstracts...
September 22, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27617697/the-epithelial-to-mesenchymal-transition-like-process-in-glioblastoma-an-updated-systematic-review-and-in-silico-investigation
#9
Isabele C Iser, Mariana B Pereira, Guido Lenz, Márcia R Wink
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer due to its highly invasive nature that impedes the surgical removal of all tumor cells, making relapse inevitable. However, the mechanisms used by glioma cells to invade the surrounding tissue are still unclear. In this context, epithelial-to-mesenchymal transition (EMT) has emerged as a key regulator of this invasive state and although the real relevance of this program in malignant glioma is still controversial, it has been strongly associated with GBM malignancy...
September 12, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/27570430/prognostic-and-predictive-biomarkers-in-metastatic-colorectal-cancer-anti-egfr-therapy
#10
Cristiana Lo Nigro, Vincenzo Ricci, Daniela Vivenza, Cristina Granetto, Teresa Fabozzi, Emanuela Miraglio, Marco C Merlano
AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers (mCRCs) addicted to epidermal growth factor receptor (EGFR) signalling. METHODS: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting mCRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of PubMed, Medline and Web of Science to identify eligible papers until March 21(st), 2016 using these following terms: ''colorectal cancer'', "predictive biomarkers'', "anti-EGFR therapy", "KRAS", "NRAS'', "PIK3CA", "TP53", "PTEN", ''EGFR", "MET", "HER2", "epiregulin", "amphiregulin", "prognostic biomarkers", "BRAF", "miRNA" and "antibody-dependent cell-mediated cytotoxicity (ADCC) activity"...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27518140/the-genomic-basis-of-noise-induced-hearing-loss-a-literature-review-organized-by-cellular-pathways
#11
Royce Ellen Clifford, Michael Hoffer, Rick Rogers
OBJECTIVE: Using Reactome, a curated Internet database, noise-induced hearing loss studies were aggregated into cellular pathways for organization of the emerging genomic and epigenetic data in the literature. DATA SOURCES: PubMed and Reactome.org, a relational data base program systematizing biological processes into interactive pathways and subpathways based on ontology, cellular constituents, gene expression, and molecular components. STUDY SELECTION: Peer-reviewed population and laboratory studies for the previous 15 years relating genomics and noise and hearing loss were identified in PubMed...
September 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27476114/a-restricted-signature-of-serum-mirnas-distinguishes-glioblastoma-from-lower-grade-gliomas
#12
Giulia Regazzo, Irene Terrenato, Manuela Spagnuolo, Mariantonia Carosi, Gaetana Cognetti, Lucia Cicchillitti, Francesca Sperati, Veronica Villani, Carmine Carapella, Giulia Piaggio, Andrea Pelosi, Maria Giulia Rizzo
BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults and challenging cancers for diagnosis and treatment. They remain a disease for which non-invasive, diagnostic and/or prognostic novel biomarkers are highly desirable. Altered microRNA (miRNA) profiles have been observed in tumor tissues and biological fluids. To date only a small set of circulating/serum miRNA is found to be differentially expressed in brain tumors compared to normal controls. Here a restricted signature of circulating/serum miRNA including miR-15b*,-23a, -99a, -125b, -133a, -150*, -197, -340, -497, -548b-5p and let-7c were investigated as potential non-invasive biomarkers in the diagnosis of glioma patients...
July 30, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27465286/candidate-micrornas-as-biomarkers-of-thyroid-carcinoma-a-systematic-review-meta-analysis-and-experimental-validation
#13
Yiren Hu, Hui Wang, Ende Chen, Zhifeng Xu, Bi Chen, Guowen Lu
Thyroid cancer is one of the most common carcinomas of the endocrine system with an increasing incidence. A growing number of studies have focused on the diagnostic and prognostic values of dysregulated microRNAs (miRNAs) in thyroid carcinoma. However, differences in the measurement platforms, variations in lab protocols, and small sample sizes can make gene profiling data incomparable. A meta-review of the published studies that compared miRNA expression data of thyroid carcinoma and paired normal tissues was performed to identify potential miRNA biomarkers of thyroid carcinoma with the vote-counting strategy...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27462777/circulating-microrna-profiles-in-plasma-identification-of-mir-224-as-a-novel-diagnostic-biomarker-in-hepatocellular-carcinoma-independent-of-hepatic-function
#14
Wataru Okajima, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Tsutomu Kawaguchi, Shoji Hirajima, Takuma Ohashi, Taisuke Imamura, Jun Kiuchi, Tomohiro Arita, Hirotaka Konishi, Atsushi Shiozaki, Ryo Moriumura, Hisashi Ikoma, Kazuma Okamoto, Hiroki Taniguchi, Yoshito Itoh, Eigo Otsuji
AIMS: This study was designed to identify novel microRNAs (miRNAs) in plasma for detecting and monitoring hepatocellular carcinoma (HCC), independent of hepatic function and background liver diseases with different etiologies. RESULTS: (1) Four oncogenic miRNAs (miR-151, 155, 191 and 224) with high expression in HCC tissues were selected as candidates. (2) Quantitative RT-PCR using plasma samples from 107 HCC patients and 75 healthy volunteers revealed a significantly higher level of plasma miR-224 in HCC patients than in healthy volunteers according to a small-scale analysis (P < 0...
July 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27438704/the-choice-of-endogenous-controls-in-exosomal-microrna-assessments-from-biofluids
#15
G Occhipinti, M Giulietti, G Principato, F Piva
The assessment of differentially expressed microRNAs in patients and healthy controls is important to identify potential tumor biomarkers. Recently, it has been shown that the microRNA levels in exosomes are more correlated with the clinical-pathological variables than vesicle-free microRNAs (miRNAs) in biofluids; therefore, there is an increasing interest in these specific evaluations. However, these measurements can be affected by experimental problems that not always are evaluated and/or by inadequate procedural choices...
July 20, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27341987/microrna-in-skeletal-muscle-its-crucial-roles-in-signal-proteins-muscle-fiber-type-and-muscle-protein-synthesis
#16
YuLan Liu, Jing Zhang
Pork is one of the most economical sources of animal protein for human consumption. Meat quality is an important economic trait for the swine industry, which is primarily determined by prenatal muscle development and postnatal growth. Identification of the molecular mechanisms underlying skeletal muscle development is a key priority. MicroRNAs (miRNAs) are a class of small noncoding RNAs that have emerged as key regulators of skeletal muscle development. A number of muscle-related miRNAs have been identified by functional gain and loss experiments in mouse model...
June 21, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27308097/diagnostic-value-of-cell-free-circulating-micrornas-for-obesity-and-type-2-diabetes-a-meta-analysis
#17
Audrey Villard, Lucien Marchand, Charles Thivolet, Sophie Rome
Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to contribute to the development of T2DM, continuous research is needed to identify specific biomarkers that could aid both in prevention of the disease and development of newer therapeutic options. Circulating miRNAs are considered as potential biomarkers because they are stable and resistant to degradation by blood RNAses and are modified under different pathophysiological conditions...
November 2015: Journal of Molecular Biomarkers & Diagnosis
https://www.readbyqxmd.com/read/27306881/epigenetics-in-medullary-thyroid-cancer-from-pathogenesis-to-targeted-therapy
#18
REVIEW
Giovanni Vitale, Alessandra Dicitore, Erika Messina, Concetta Sciammarella, Antongiulio Faggiano, Annamaria Colao
BACKGROUND: Medullary thyroid carcinoma (MTC) originates from the parafollicular C cells of the thyroid gland. Mutations of the RET proto-oncogene are implicated in the pathogenesis of MTC. Germline activating mutations of this gene have been reported in about 88-98% of familial MTCs, while somatic mutations of RET gene have been detected in about 23-70% of sporadic forms. Although these genetic events are well characterized, much less is known about the role of epigenetic abnormalities in MTC...
2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27259231/diagnostic-value-of-micrornas-in-asbestos-exposure-and-malignant-mesothelioma-systematic-review-and-qualitative-meta-analysis
#19
Luigina Micolucci, Most Mauluda Akhtar, Fabiola Olivieri, Maria Rita Rippo, Antonio Domenico Procopio
BACKGROUND: Asbestos is a harmful and exceptionally persistent natural material. Malignant mesothelioma (MM), an asbestos-related disease, is an insidious, lethal cancer that is poorly responsive to current treatments. Minimally invasive, specific, and sensitive biomarkers providing early and effective diagnosis in high-risk patients are urgently needed. MicroRNAs (miRNAs, miRs) are endogenous, non-coding, small RNAs with established diagnostic value in cancer and pollution exposure. A systematic review and a qualitative meta-analysis were conducted to identify high-confidence miRNAs that can serve as biomarkers of asbestos exposure and MM...
June 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27248468/mirna-expression-and-function-in-thyroid-carcinomas-a-comparative-and-critical-analysis-and-a-model-for-other-cancers
#20
Manuel Saiselet, Jaime M Pita, Alice Augenlicht, Geneviève Dom, Maxime Tarabichi, Danai Fimereli, Jacques E Dumont, Vincent Detours, Carine Maenhaut
As in many cancer types, miRNA expression profiles and functions have become an important field of research on non-medullary thyroid carcinomas, the most common endocrine cancers. This could lead to the establishment of new diagnostic tests and new cancer therapies. However, different studies showed important variations in their research strategies and results. In addition, the action of miRNAs is poorly considered as a whole because of the use of underlying dogmatic truncated concepts. These lead to discrepancies and limits rarely considered...
May 28, 2016: Oncotarget
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