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miRNA systematic review

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https://www.readbyqxmd.com/read/29761766/factors-associated-with-the-rapid-and-durable-decline-in-malaria-incidence-in-el-salvador-1980-2017
#1
Robert A Burton, José Eduardo Romero Chévez, Mauricio Sauerbrey, Caterina Guinovart, Angela Hartley, Geoffrey Kirkwood, Matthew Boslego, Mirna Elizabeth Gavidia, Jaime Enrique Alemán Escobar, Rachel Turkel, Richard W Steketee, Laurence Slutsker, Kammerle Schneider, Carlos C Kent Campbell
A decade after the Global Malaria Eradication Program, El Salvador had the highest burden of malaria in Mesoamerica, with approximately 20% due to Plasmodium falciparum . A resurgence of malaria in the 1970s led El Salvador to alter its national malaria control strategy. By 1995, El Salvador recorded its last autochthonous P. falciparum case with fewer than 20 Plasmodium vivax cases annually since 2011. By contrast, its immediate neighbors continue to have the highest incidences of malaria in the region. We reviewed and evaluated the policies and interventions implemented by the Salvadoran National Malaria Program that likely contributed to this progress toward malaria elimination...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29749132/prognostic-value-of-micrornas-in-coronary-artery-diseases-a-meta-analysis
#2
Ji Suk Kim, Kyoungjune Pak, Tae Sik Goh, Dae Cheon Jeong, Myoung Eun Han, Jihyun Kim, Sae Ock Oh, Chi Dae Kim, Yun Hak Kim
PURPOSE: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29739059/lncrna-pvt1-a-novel-therapeutic-target-for-cancers
#3
REVIEW
Xuefeng Pan, Guobao Zheng, Chunfang Gao
BACKGROUND: Long non-coding RNA PVT1, as an important carcinogenic lncRNA, is highly expressed in many malignant tumors and suggests a poorer prognosis. It can promote the occurrence and development of cancers by affecting cell proliferation, migration, invasion and apoptosis. This article reviews the progress of lncRNA PVT1 on cancer therapy, in order to facilitate the in-depth study of lncRNA PVT1 acting as a promising target for therapy in cancers. METHODS: We extracted all relevant studies of lncRNA PVT1 on the treatment of cancers by searching electronic databases Pubmed, Embase, Web of Science from inception to November 30, 2017...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29718912/microrna-profiles-and-functions-in-mosquitoes
#4
Xinyu Feng, Shuisen Zhou, Jingwen Wang, Wei Hu
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms...
May 2, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29717029/a-comprehensive-evaluation-for-polymorphisms-in-let-7-family-in-cancer-risk-and-prognosis-a-system-review-and-meta-analysis
#5
Ben-Gang Wang, Li-Yue Jiang, Qian Xu
MiRNA polymorphisms had potential to be biomarkers for cancer susceptibility and prognosis. The mature miRNA-let-7 family was considered as the most important miRNAs for the cancer incidence and progression. Recently, the promising let-7 miRNAs were reported to be associated with various cancers, but the results were inconsistent. We performed a first reported systematically review with a meta-analysis for the association of let-7 family SNPs with cancer risk/prognosis. Ten studies were included with a total of 3,878 cancer cases and 4,725 controls for the risk study, 1,665 cancer patients for the prognosis study in this meta-analysis...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29706994/association-of-three-polymorphisms-rs11614913-rs2910146-and-rs3746444-in-mirna-196a2-mirna-146a-and-mirna-499-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Ying Liu, Lingxin Xiong, Yan Zhou, Bingzhen Zheng, Tongjun Liu, Wei Xie
Background: It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship. Methods: We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29683754/micrornas-in-idiopathic-pulmonary-fibrosis-new-research-progress-and-their-pathophysiological-implication
#7
Chenggui Miao, Youyi Xiong, Guoxue Zhang, Jun Chang
Many studies have shown that microRNAs (miRNAs) play important roles in the development of idiopathic pulmonary fibrosis (IPF). The purpose of this review is to systematically summarize the recent advance of miRNAs in the pathology of IPF, highlighting the new research progress and their pathophysiological implication. Recent studies have shown that miRNAs differentially expressed in blood and lung tissue from IPF patients are closely related to the occurrence of IPF disease, which may be IPF diagnostic markers and prognostic indicators...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29682211/systematic-review-and-meta-analysis-of-the-prognostic-significance-of-micrornas-in-cervical-cancer
#8
Zhilan Chen, Yingyan Han, Chengwen Song, Huafang Wei, Ying Chen, Kecheng Huang, Shuang Li, Ding Ma, Shixuan Wang, Jing Wang, Qiping Lu
In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1.61, 95% CI: 1...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29667572/neurobiological-findings-associated-with-high-cognitive-performance-in-older-adults-a-systematic-review
#9
Wyllians Vendramini Borelli, Lucas Porcello Schilling, Graciane Radaelli, Luciana Borges Ferreira, Leonardo Pisani, Mirna Wetters Portuguez, Jaderson Costa da Costa
ABSTRACTObjectives:to perform a comprehensive literature review of studies on older adults with exceptional cognitive performance. DESIGN: We performed a systematic review using two major databases (MEDLINE and Web of Science) from January 2002 to November 2017. RESULTS: Quantitative analysis included nine of 4,457 studies and revealed that high-performing older adults have global preservation of the cortex, especially the anterior cingulate region, and hippocampal volumes larger than normal agers...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29593419/functional-mirnas-in-breast-cancer-drug-resistance
#10
REVIEW
Weizi Hu, Chunli Tan, Yunjie He, Guangqin Zhang, Yong Xu, Jinhai Tang
Owing to improved early surveillance and advanced therapy strategies, the current death rate due to breast cancer has decreased; nevertheless, drug resistance and relapse remain obstacles on the path to successful systematic treatment. Multiple mechanisms responsible for drug resistance have been elucidated, and miRNAs seem to play a major part in almost every aspect of cancer progression, including tumorigenesis, metastasis, and drug resistance. In recent years, exosomes have emerged as novel modes of intercellular signaling vehicles, initiating cell-cell communication through their fusion with target cell membranes, delivering functional molecules including miRNAs and proteins...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29566385/a-comprehensive-assessment-of-the-role-of-mirnas-as-biomarkers-in-gastroenteropancreatic-neuroendocrine-tumors
#11
Anna Malczewska, Mark Kidd, Somer Matar, Beata Kos-Kudla, Irvin M Modlin
BACKGROUND/AIMS: A key issue in neuroendocrine neoplasia management is the identification of blood signatures that specifically define the activity of a cancer or local tumor microenvironment. MicroRNAs (miRNAs) may represent such a candidate. To evaluate their clinical utility as biomarkers in gastroenteropancreatic neuroendocrine tumors (GEP-NETs), we assessed their expression in tissue and blood. METHODS: A systematic review of PubMed was undertaken to identify studies investigating miRNAs in GEP-NETs and their utility as blood or tissue biomarkers...
March 22, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/29556176/conflicting-effects-of-methylglyoxal-and-potential-significance-of-mirnas-for-seizure-treatment
#12
REVIEW
Hua Tao, Xu Zhou, Bin Zhao, Keshen Li
According to an update from the World Health Organization, approximately 50 million people worldwide suffer from epilepsy, and nearly one-third of these individuals are resistant to the currently available antiepileptic drugs, which has resulted in an insistent pursuit of novel strategies for seizure treatment. Recently, methylglyoxal (MG) was demonstrated to serve as a partial agonist of the gamma-aminobutyric acid type A (GABAA ) receptor and to play an inhibitory role in epileptic activities. However, MG is also a substrate in the generation of advanced glycation end products (AGEs) that function by activating the receptor of AGEs (RAGE)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29533734/predictive-prognostic-value-of-tissue-based-microrna-expression-in-oral-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#13
G Troiano, F Mastrangelo, V C A Caponio, L Laino, N Cirillo, L Lo Muzio
Oral squamous cell carcinoma (OSCC) is a common type of cancer characterized by a low survival rate, mostly due to local recurrence and metastasis. In view of the importance of predicting tumor behavior in the choice of treatment strategies for OSCC, several studies have attempted to investigate the prognostic value of tissue biomarkers, including microRNA (miRNA). The purpose of this study was to perform a systematic review and meta-analysis to evaluate the relationship between miRNA expression and survival of OSCC patients...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29487725/microrna-involvement-in-the-onset-and-progression-of-barrett-s-esophagus-a-systematic-review
#14
REVIEW
Reilly J Clark, Michael P Craig, Sangeeta Agrawal, Madhavi Kadakia
Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that develops from Barrett's esophagus (BE), an intestinal metaplasia of the distal esophagus. microRNAs (miRNAs), short non-coding regulatory RNAs, are frequently dysregulated in BE and are thought to play key roles in the onset of BE and its progression to EAC. miRNAs thus have potential diagnostic and prognostic value and are increasingly being used as cancer biomarkers. This review summarizes the current literature related to miRNAs that are dysregulated in BE within the context of Hedgehog, Notch, MAPK, NF kappa-B, Wnt and epithelial-mesenchymal transition (EMT) signaling which are thought to drive BE onset and progression...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29487703/network-analysis-of-micrornas-genes-and-their-regulation-in-diffuse-and-follicular-b-cell-lymphomas
#15
Oshrat Hershkovitz-Rokah, Polina Geva, Mali Salmon-Divon, Ofer Shpilberg, Stella Liberman-Aronov
MicroRNAs (miRs) are short non-coding regulatory RNAs that control gene expression at the post-transcriptional level and play an important role in cancer development and progression, acting either as oncogenes or as tumor suppressors. Identification of aberrantly expressed miRs in patients with hematological malignancies as compared to healthy individuals has suggested that these molecules may serve as novel clinical diagnostic and prognostic biomarkers. We conducted a systematic literature review of articles published between 2007 and 2017 and re-analyzed experimentally-validated human miR expression signatures in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) from various biological sources (tumor tissue, peripheral blood, bone marrow and cell lines)...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29485797/healthy-settings-in-hospital-how-to-prevent-burnout-syndrome-in-nurses-literature-review
#16
REVIEW
Adriano Friganović, Irena Kovačević, Boris Ilić, Mirna Žulec, Valentina Krikšić, Cecilija Grgas Bile
Healthy settings involve a holistic and multidisciplinary method that integrates actions towards risk factors. In hospital settings, a high level of stress can lead to depression, anxiety, decreased job satisfaction and lower loyalty to the organization. Burnout syndrome can be defined as physical, psychological and emotional exhaustion, depersonalization, and low sense of personal accomplishment. The aim of this literature review was to make systematic literature analysis to provide scientific evidence for the consequences of constant exposure to high levels of stress and for the methods to be used to prevent burnout syndrome among health care workers...
June 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29479135/circulating-liver-specific-micrornas-in-cynomolgus-monkeys
#17
REVIEW
Takuma Iguchi, Ken Sakurai, Satoshi Tamai, Kazuhiko Mori
Circulating microRNAs (miRNAs) can potentially be used as sensitive and specific biomarkers for tissue injury. However, the usefulness of circulating miRNAs as safety biomarkers in nonclinical toxicological studies using nonhuman primates is debatable owing to the limited information on organ-specific miRNAs. Therefore, a systematic investigation was performed to address this point. We identified organ-specific miRNAs from cynomolgus monkeys by next-generation sequencing analysis, which revealed that miR-122 was only abundant in the liver, whereas miR-192 was abundant in the liver, stomach, intestines, and kidney...
January 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29475039/genes-and-micrornas-associated-with-mouse-cleft-palate-a-systematic-review-and-bioinformatics-analysis
#18
Akiko Suzuki, Nada Abdallah, Mona Gajera, Goo Jun, Peilin Jia, Zhongming Zhao, Junichi Iwata
Cleft palate (CP) is the most prevalent craniofacial deformity, with ethnic and geographic variation in prevalence in humans. Mice have been used as an animal model to study the cause(s) of CP by several approaches, including genetic and chemical-induced approaches. Mouse genetic approaches revealed that significant amounts of genes are involved in the CP pathology. The aim of this study was to identify common features of CP-associated genes and to explore the roles of microRNAs (miRNAs) as important post-transcriptional regulators that may be involved in the regulation of CP genes...
April 2018: Mechanisms of Development
https://www.readbyqxmd.com/read/29463003/the-mirna-mirage-how-close-are-we-to-finding-a-non-invasive-diagnostic-biomarker-in-endometriosis-a-systematic-review
#19
REVIEW
Swati Agrawal, Thomas Tapmeier, Nilufer Rahmioglu, Shona Kirtley, Krina Zondervan, Christian Becker
BACKGROUND: Endometriosis is a common disorder of the reproductive age group, characterised by the presence of ectopic endometrial tissue. The disease not only causes enormous suffering to the affected women, but also brings a tremendous medical and economic burden to bear on society. There is a long lag phase between the onset and diagnosis of the disease, mainly due to its non-specific symptoms and the lack of a non-invasive test. Endometriosis can only be diagnosed invasively by laparoscopy...
February 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29435194/mirna-dysregulation-and-the-risk-of-metastasis-and-invasion-in-papillary-thyroid-cancer-a-systematic-review-and-meta-analysis
#20
REVIEW
Tiantian Wang, Hao Xu, Ming Qi, Sheng Yan, Xingsong Tian
Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for "invasion", "thyroid cancer", and "miRNA"...
January 12, 2018: Oncotarget
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