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miRNA systematic review

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https://www.readbyqxmd.com/read/28317401/biological-implications-and-clinical-value-of-mir-210-in-gastrointestinal-cancer
#1
Wanli Yang, Jiaojiao Ma, Wei Zhou, Xin Zhou, Bo Cao, Daiming Fan, Liu Hong
Introduction Hypoxia, a common feature of tumor microenvironment, is known to accelerate tumor development and growth by promoting the formation of a neoplastic environment. Recent studies have provided a wealth of evidence that miRNAs are significant members of the adaptive response to low oxygen in tumors. miR-210 is one of the hypoxia-induced miRNAs, which has been reported extensively in cancer researches. However, there is no systematic discussion about the role of miR-210 in gastrointestinal cancer. We conducted a literature research in database including PubMed, Elsevier Science Direct and Medline before September 16, 2016, in order to collect articles of miR-210 in gastrointestinal cancer...
March 18, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28286901/the-effects-of-micrornas-on-glucocorticoid-responsiveness
#2
REVIEW
Huimin Wang, Xuxu Gou, Tang Jiang, Juan Ouyang
PURPOSE: Glucocorticoids (GCs) are of wide usage in the clinical treatment of lymphoblastic malignancies such as acute lymphoblastic leukemia. However, individually distinctive responsiveness to the GC therapy may attenuate their clinical efficacy, and more reliable predictor for GC resistance is still eagerly needed. Recent studies indicate that microRNAs (miRNAs), which demonstrate regulatory functions targeting mRNAs during the post-transcription, involved in the regulation of GCs sensitivity through several mechanisms, especially adjusting the magnitude of GC receptors (GRs), which mediates the cellular effects of GCs and plays a pivotal role in GCs sensitivity, inspiring that special miRNAs pattern could serve as the biomarkers to predict GC sensitivity and bring forth potential strategies for overcoming drug resistance...
March 12, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28282769/epigenetic-modifications-of-human-placenta-associated-with-preterm-birth-a-systematic-review
#3
Drissa M Toure, Wael ElRayes, Debora Barnes-Josiah, Teresa Hartman, David Klinkebiel, Lorena Baccaglini
OBJECTIVE: Preterm birth (PTB) is one of the leading causes of neonatal mortality and morbidity around the world. Epigenetic alterations of the human placenta may be involved in the causal chain of adverse pregnancy outcomes specifically PTB. In this systematic review, we investigated whether epigenetic dysregulation of the human placenta is associated with PTB. METHODS: We searched MEDLINE and EMBASE and systematically reviewed all relevant studies on epigenetic placental modifications in PTB...
February 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28259298/the-cornerstone-k-ras-mutation-in-pancreatic-adenocarcinoma-from-cell-signaling-network-target-genes-biological-processes-to-therapeutic-targeting
#4
REVIEW
Nicolas Jonckheere, Romain Vasseur, Isabelle Van Seuningen
RAS belongs to the super family of small G proteins and plays crucial roles in signal transduction from membrane receptors in the cell. Mutations of K-RAS oncogene lead to an accumulation of GTP-bound proteins that maintains an active conformation. In the pancreatic ductal adenocarcinoma (PDAC), one of the most deadly cancers in occidental countries, mutations of the K-RAS oncogene are nearly systematic (>90%). Moreover, K-RAS mutation is the earliest genetic alteration occurring during pancreatic carcinogenetic sequence...
March 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28164670/prognostic-value-of-expression-of-micrornas-in-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#5
Bingxiang Zhan, Dapeng Lu, Peng Luo, Baolong Wang
BACKGROUND: microRNAs are widely involved in a variety of life processes and considered as potential biomarkers of tumor prognosis. A growing number of studies have documented that miRNAs were associated with outcome in NSCLC patients and can act as a prognostic marker. However, existing studies concerning the relationship between miRNAs and outcome in NSCLC patients were contentious and dispersive. Therefore, a systematic metaanalysis to explore the prognostic value of miRNAs on NSCLC patients is urgently needed...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164621/prognostic-value-of-mir-222-in-various-cancers-a-systematic-review-and-meta-analysis
#6
REVIEW
Tai Wei, Peng Ye, Xin Peng, Li-Ling Wu, Guang-Yan Yu
BACKGROUND: MicroRNAs (miRNAs) play important roles in cancer development. MiR-222, which is deregulated in multiple types of cancers, shows potential as a prognostic biomarker; however, the association between miR222 expression and cancer prognosis was controversial in previous studies. Here we analyzed the relationship between miR-222 and the survival of cancer patients. METHODS: A systematic search of PubMed, Web of Science, Ovid, SciFinder, Cochrane Library, Wan Fang, and the Chinese National Knowledge Infrastructure databases up until June 8, 2015 was performed to clarify the prognostic value of miR-222 in cancers...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28152545/blood-based-micrornas-as-biomarkers-for-the-diagnosis-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#7
Jane V Carter, Norman J Galbraith, Dongyan Yang, James F Burton, Samuel P Walker, Susan Galandiuk
BACKGROUND: Colorectal cancer (CRC) is common and associated with significant mortality. Current screening methods for CRC lack patient compliance. microRNAs (miRNAs), identified in body fluids, are negative regulators of gene expression and are dysregulated in many cancers, including CRC. This paper summarises studies identifying blood-based miRNAs dysregulated in CRC compared with healthy controls in an attempt to evaluate their use as a screening tool for the diagnosis of CRC. METHODS: A search of electronic databases (PubMed and EMBASE) and grey literature was performed between January 2002 and April 2016...
March 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28133000/progress-of-research-on-micrornas-with-diagnostic-value-in-asbestos-exposure-a-call-for-method-standardization
#8
Luigina Micolucci, Maria Rita Rippo, Fabiola Olivieri, Antonio Domenico Procopio
Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs with a well-established diagnostic role in cancer and pollution exposure. In a recent systematic review and qualitative meta-analysis followed by a functional investigation, we examined all the available data on the miRNA biomarkers involved in asbestos exposure and MM pathways...
January 30, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28068481/micrornas-and-periodontal-homeostasis
#9
X Luan, X Zhou, J Trombetta-eSilva, M Francis, A K Gaharwar, P Atsawasuwan, T G H Diekwisch
MicroRNAs (miRNAs) are a group of small RNAs that control gene expression in all aspects of eukaryotic life, primarily through RNA silencing mechanisms. The purpose of the present review is to introduce key miRNAs involved in periodontal homeostasis, summarize the mechanisms by which they affect downstream genes and tissues, and provide an introduction into the therapeutic potential of periodontal miRNAs. In general, miRNAs function synergistically to fine-tune the regulation of biological processes and to remove expression noise rather than by causing drastic changes in expression levels...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28065383/molecular-alterations-contributing-to-pancreatic-cancer-chemoresistance
#10
REVIEW
Azam Rajabpour, Farzad Rajaei, Ladan Teimoori-Toolabi
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death all over the world. This disease is difficult to treat and patients have an overall 5-year survival rate of less than 5%. Although two drugs, gemcitabine (GEM) and 5-fluorouracil (5-FU) have been shown to improve the survival rate of patients systematically, they do not increase general survival to a clinically acceptable degree. Lack of ideal clinical response of pancreatic cancer patients to chemotherapy is likely to be due to intrinsic and acquired chemoresistance of tumor cells...
December 28, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28063172/prognostic-value-of-the-microrna-29-family-in-multiple-human-cancers-a-meta-analysis-and-systematic-review
#11
Yan Qi, Yalan Huang, Lijuan Pang, Wenyi Gu, Ning Wang, Jianming Hu, Xiaobin Cui, Jun Zhang, Jin Zhao, Chunxia Liu, Wenjie Zhang, Hong Zou, Feng Li
MicroRNAs (miRNAs) in cancer development have attracted much attention in recent years. miR-29 is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain situations. The prognostic value of miR-29 family in cancer progression is still under debate and reported results are inconsistent. Therefore, we reported here a meta-analysis and systematic review to analyze the prognostic role of miR-29 family in cancer. We screened 20 published studies and calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for overall survival (OS) or disease-free survival/recurrence-free survival (DFS/RFS)...
January 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27993167/prognostic-value-of-cross-omics-screening-for-kidney-clear-cell-renal-cancer-survival
#12
Slavica Dimitrieva, Ralph Schlapbach, Hubert Rehrauer
BACKGROUND: Kidney renal clear cell carcinoma (KIRC) is a type of cancer that is resistant to chemotherapy and radiotherapy and has limited treatment possibilities. Large-scale molecular profiling of KIRC tumors offers a great potential to uncover the genetic and epigenetic changes underlying this disease and to improve the clinical management of KIRC patients. However, in practice the clinicians and researchers typically focus on single-platform molecular data or on a small set of genes...
December 20, 2016: Biology Direct
https://www.readbyqxmd.com/read/27957388/microrna-biogenesis-pathway-genes-polymorphisms-and-cancer-risk-a-systematic-review-and-meta-analysis
#13
Jieyu He, Jun Zhao, Wenbo Zhu, Daxun Qi, Lina Wang, Jinfang Sun, Bei Wang, Xu Ma, Qiaoyun Dai, Xiaojin Yu
MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk...
2016: PeerJ
https://www.readbyqxmd.com/read/27938997/circulating-mirnas-from-blood-plasma-or-serum-as-promising-clinical-biomarkers-in-oral-squamous-cell-carcinoma-a-systematic-review-of-current-findings
#14
REVIEW
Giuseppe Troiano, Linda Boldrup, Fatima Ardito, Xaolian Gu, Lorenzo Lo Muzio, Karin Nylander
The purpose of this systematic review was to summarize current findings on the use of circulating miRNAs from blood, serum and plasma as cancer biomarkers in patients with oral squamous cell carcinoma. Studies were gathered after searching four different electronic databases: PUBMED, SCOPUS, Cochrane Library and Web of Science. Additional search was carried out through cross check on bibliography of selected articles. After the selection process made by two of the authors, 16 articles met the inclusion criteria and were included in the review...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27917109/role-of-micrornas-in-the-regulation-of-%C3%AE-synuclein-expression-a-systematic-review
#15
REVIEW
Ariadna Recasens, Celine Perier, Carolyn M Sue
Growing evidence suggests that increased levels of α-synuclein might contribute to the pathogenesis of Parkinson's disease (PD) and therefore, it is crucial to understand the mechanisms underlying α-synuclein expression. Recently, microRNAs (miRNAs) have emerged as key regulators of gene expression involved in several diseases such as PD and other neurodegenerative disorders. A systematic literature search was performed here to identify microRNAs that directly or indirectly impact in α-synuclein expression/accumulation and describe its mechanism of action...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27894413/targeting-of-bcr-abl-lessons-learned-from-bcr-abl-inhibition
#16
REVIEW
X Lin, M Z Qureshi, R Attar, S Khalid, F Tahir, A Yaqub, A Aslam, I Yaylim, L K De Carlos Back, A A Farooqi, M Ismail
In 1960 researchers reported that balanced translocation between chromosomes 22 and 9 resulted in the generation of Philadelphia chromosome. This breakthrough revolutionized our knowledge related to leukemia biology and contemporary studies revealed that chromosomal translocation resulted in the fusion between the 5' segment of BCR gene and 3' segment of the ABL gene to form BCR/ABL fusion gene. Research over the years has progressively and systematically improved our understanding of the genetic and proteomic basis of Leukemia...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27878945/regulatory-non-coding-rnas-in-acute-myocardial-infarction
#17
REVIEW
Yuan Guo, Fei Luo, Qiong Liu, Danyan Xu
Acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that leads to high mortality and morbidity globally. Various therapeutic targets for AMI have been investigated in recent years, including the non-coding RNAs (ncRNAs). NcRNAs, a class of RNA molecules that typically do not code proteins, are divided into several subgroups. Among them, microRNAs (miRNAs) are widely studied for their modulation of several pathological aspects of AMI, including cardiomyocyte apoptosis, inflammation, angiogenesis and fibrosis...
November 23, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27870469/a-panel-of-circulating-mirnas-as-diagnostic-biomarkers-for-screening-multiple-myeloma-a-systematic-review-and-meta-analysis
#18
REVIEW
L Zhang, D Cao, L Tang, C Sun, Y Hu
Circulating microRNAs (miRNAs) have been proved to be effective diagnostic markers for multiple myeloma (MM). The meta-analysis was aimed to evaluate the diagnostic value of related miRNAs. Multiple databases (PubMed, Web of Science, EMBASE, Cochrane Library, CBM, and CNKI) were systematically searched for available studies up to March 2016. All data were analyzed with the help of software revman 5.3 and metadisc 1.4. The eligible articles' quality was estimated by QUADAS-2, and pooled parameters were acquired with the bivariate random-effects meta-analysis model...
December 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27802200/modern-molecular-biomarkers-of-head-and-neck-cancer-part-i-epigenetic-diagnostics-and-prognostics-systematic-review
#19
REVIEW
Gintaras Juodzbalys, David Kasradze, Marco Cicciù, Aurimas Sudeikis, Laurynas Banys, Pablo Galindo-Moreno, Zygimantas Guobis
INTRODUCTION: Nearly half of the head and neck cancer cases are diagnosed in late stages. Traditional screening modalities have many disadvantages. The aim of the present article was to review the scientific literature about novel head and neck cancer diagnostics - epigenetic biomarkers. EVIDENCE ACQUISITION: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in English language published from 2004 to 2015...
2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27729619/role-of-an-imbalanced-mirnas-axis-in-pathogenesis-of-psoriasis-novel-perspectives-based-on-review-of-the-literature
#20
REVIEW
Mao-Jie Wang, Yong-Yue Xu, Run-Yue Huang, Xiu-Min Chen, Hai-Ming Chen, Ling Han, Yu-Hong Yan, Chuan-Jian Lu
BACKGROUND: Specific profile of microRNAs (miRNAs, miR) expressed in psoriasis has been identified in the past few years, while the studies on roles and molecular mechanisms of these miRNAs are still on the way. In our previous study, four specific miRNAs (miR-31, miR-203, hsa-miR-99a and miR-125b) were found to be specifically altered in psoriatic lesions.We therefore conducted a systematic literature review in this study to reveal the role of these miRNAs in the pathogenesis of psoriasis in order to inform future research...
January 17, 2017: Oncotarget
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