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https://www.readbyqxmd.com/read/29793154/juvenile-treatment-with-mglur2-3-agonist-prevents-schizophrenia-like-phenotypes-in-adult-by-acting-through-gsk3%C3%AE
#1
Bo Xing, Genie Han, Min-Juan Wang, Melissa A Snyder, Wen-Jun Gao
Prodromal memory deficits represent an important marker for the development of schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex (PFC). The mGluR2/3 agonist LY379268 (LY37) attenuates excitatory N-methyl-D-aspartate receptor (NMDAR)-induced neurotoxicity, a central pathological characteristic of glutamatergic hypofunction. We therefore hypothesized that early treatment with LY37 would rescue cognitive deficits and confer benefits for SZ-like behaviors in adults. To test this, we assessed whether early intervention with LY37 would improve learning outcomes in the Morris Water Maze for rats prenatally exposed to methylazoxymethanol acetate (MAM), a neurodevelopmental SZ model...
May 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29793150/exploring-the-victimization%C3%A2-early-substance-misuse-relationship-in-search-of-moderating-and-mediating-effects
#2
Glenn D Walters, Dorothy L Espelage
This study was designed to address two research questions. The first research question asked whether physical abuse victimization at the hands of parents/guardians, bullying victimization at the hands of peers, and the abuse x bullying interaction encouraged early involvement in substance misuse. The second research question inquired as to whether the victimization‒substance misuse relationship was mediated by variables proposed by various theories and research studies-specifically, cognitive impulsivity, negative affect, and low self-esteem...
May 21, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29792953/protective-effect-of-s-nitrosoglutathione-administration-against-hyperglycemia-induced-disruption-of-blood-brain-barrier-is-mediated-by-alterations-in-tight-junction-proteins-and-cell-adhesion-molecules
#3
Aanchal Aggarwal, Inderjit Singh, Rajat Sandhir
Diabetes is associated with increased blood brain barrier (BBB) permeability resulting in neurological deficits. The present study investigated the role of S-nitrosoglutathione (GSNO) on tight junction proteins and cell adhesion molecules in streptozotocin-induced diabetic mice. Diabetes was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) for 5 days in mice. GSNO was administered daily (100 μg/kg body weight, orally) for 8 weeks after the induction of diabetes. A significant decline was observed in the cognitive ability of diabetic animals assessed using radial arm maze test...
May 21, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29792878/deoxyelephantopin-ameliorates-lipopolysaccharides-lps-induced-memory-impairments-in-rats-evidence-for-its-anti-neuroinflammatory-properties
#4
Shathiswaran N Andy, Vijayapandi Pandy, Zazali Alias, Habsah Abdul Kadir
AIM: Neuroinflammation is a critical pathogenic mechanism of most neurodegenerative disorders especially, Alzheimer's disease (AD). Lipopolysaccharides (LPS) are known to induce neuroinflammation which is evident from significant upsurge of pro-inflammatory mediators in in vitro BV-2 microglial cells and in vivo animal models. In present study, we investigated anti-neuroinflammatory properties of deoxyelephantopin (DET) isolated from Elephantopus scaber in LPS-induced neuroinflammatory rat model...
May 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29792585/assessment-in-work-productivity-and-the-relationship-with-cognitive-symptoms-atworc-primary-analysis-from-a-canadian-open-label-study-of-vortioxetine-in-patients-with-major-depressive-disorder-mdd
#5
Pratap Chokka, Joanna Bougie, Emmanouil Rampakakis, Jean Proulx
OBJECTIVE: The Assessment in Work Productivity and the Relationship with Cognitive Symptoms (AtWoRC) study aimed to assess the association between cognitive symptoms and work productivity in gainfully employed patients receiving vortioxetine for a major depressive episode (MDE). METHODS: Patients diagnosed with major depressive disorder (MDD) and treated with vortioxetine independently of study enrollment were assessed over 52 weeks at visits that emulated a real-life setting...
May 24, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29792493/does-increased-effort-compensate-for-performance-debilitating-test-anxiety
#6
David W Putwain, Wendy Symes
It is well established that test anxiety is negatively related to examination performance. Based on attentional control theory, the aim of this study was to examine whether increased effort can protect against performance debilitating test anxiety. Four hundred and sixty-six participants (male = 228; 48.9%; White = 346, 74.3%; mean age = 15.7 years) completed self-report measures of test anxiety and effort that were matched to performance on a high-stakes secondary school examination. The worry and bodily symptoms components of test anxiety were negatively, and effort, positively related to examination performance...
May 24, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29792473/cognitive-and-affective-associations-with-an-ecologically-valid-test-of-theory-of-mind-across-the-lifespan
#7
Emilie Johansson Nolaker, Kim Murray, Francesca Happé, Rebecca A Charlton
OBJECTIVES: Many studies have demonstrated that theory of mind (ToM) ability declines with increasing age. Research has found that ToM-age associations are often mediated by other cognitive abilities particularly executive function. However, older adults rarely complain about real-world ToM difficulties. It has been suggested that older adults may perform better in real-world situations compared with experimental settings. METHOD: We examined performance on the Strange Stories Film Task (SSFT) which has been designed to assess ToM using naturalistic, video scenarios...
May 24, 2018: Neuropsychology
https://www.readbyqxmd.com/read/29792242/testing-a-stepped-care-model-for-binge-eating-disorder-a-two-step-randomized-controlled-trial
#8
Giorgio A Tasca, Diana Koszycki, Agostino Brugnera, Livia Chyurlia, Nicole Hammond, Kylie Francis, Kerri Ritchie, Iryna Ivanova, Genevieve Proulx, Brian Wilson, Julie Beaulac, Hany Bissada, Erin Beasley, Nancy Mcquaid, Renee Grenon, Benjamin Fortin-Langelier, Angelo Compare, Louise Balfour
BACKGROUND: A stepped care approach involves patients first receiving low-intensity treatment followed by higher intensity treatment. This two-step randomized controlled trial investigated the efficacy of a sequential stepped care approach for the psychological treatment of binge-eating disorder (BED). METHODS: In the first step, all participants with BED (n = 135) received unguided self-help (USH) based on a cognitive-behavioral therapy model. In the second step, participants who remained in the trial were randomized either to 16 weeks of group psychodynamic-interpersonal psychotherapy (GPIP) (n = 39) or to a no-treatment control condition (n = 46)...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792241/efficacy-of-digital-cbt-for-insomnia-to-reduce-depression-across-demographic-groups-a-randomized-trial
#9
Philip Cheng, Annemarie I Luik, Cynthia Fellman-Couture, Edward Peterson, Christine L M Joseph, Gabriel Tallent, Kieulinh Michelle Tran, Brian K Ahmedani, Timothy Roehrs, Thomas Roth, Christopher L Drake
BACKGROUND: Insomnia and depression are highly comorbid and mutually exacerbate clinical trajectories and outcomes. Cognitive behavioral therapy for insomnia (CBT-I) effectively reduces both insomnia and depression severity, and can be delivered digitally. This could substantially increase the accessibility to CBT-I, which could reduce the health disparities related to insomnia; however, the efficacy of digital CBT-I (dCBT-I) across a range of demographic groups has not yet been adequately examined...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792238/mapping-the-neuroanatomic-substrates-of-cognition-in-familial-attention-deficit-hyperactivity-disorder
#10
Rachel Muster, Saadia Choudhury, Wendy Sharp, Steven Kasparek, Gustavo Sudre, Philip Shaw
BACKGROUND: While the neuroanatomic substrates of symptoms of attention deficit hyperactivity disorder (ADHD) have been investigated, less is known about the neuroanatomic correlates of cognitive abilities pertinent to the disorder, particularly in adults. Here we define the neuroanatomic correlates of key cognitive abilities and determine if there are associations with histories of psychostimulant medication. METHODS: We acquired neuroanatomic magnetic resonance imaging data from 264 members of 60 families (mean age 29...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792234/long-term-outcomes-of-acute-treatment-with-cognitive-therapy-v-interpersonal-psychotherapy-for-adult-depression-follow-up-of-a-randomized-controlled-trial
#11
Lotte H J M Lemmens, Suzanne C van Bronswijk, Frenk Peeters, Arnoud Arntz, Steven D Hollon, Marcus J H Huibers
BACKGROUND: Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD. METHODS: One hundred thirty-four adult (18-65) depressed outpatients who were treated with CT (n = 69) or IPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792087/effects-of-intensive-short-term-dynamic-psychotherapy-on-social-cognition-in-major-depression
#12
Bita Ajilchi, Steve Kisely, Vahid Nejati, Jon Frederickson
BACKGROUND: Social cognition is commonly affected in psychiatric disorders and is a determinant of quality of life. However, there are few studies of treatment. OBJECTIVE: To investigate the efficacy of intensive short-term dynamic psychotherapy on social cognition in major depression. METHOD: This study used a parallel group randomized control design to compare pre-test and post-test social cognition scores between depressed participants receiving ISTDP and those allocated to a wait-list control group...
May 23, 2018: Journal of Mental Health
https://www.readbyqxmd.com/read/29791867/longitudinal-assessment-of-chemotherapy-induced-changes-in-brain-and-cognitive-functioning-a-systematic-review
#13
REVIEW
Mingmei Li, Karen Caeyenberghs
In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function ("chemobrain"). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitudinal design. This review followed the latest PRISMA guidelines using Embase, Medline, PsychINFO, Scopus, and Web of Science databases with date restrictions from 2012-2017...
May 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29791634/effects-of-health-education-in-the-elderly-with-mild-cognitive-impairment
#14
Francine Golghetto Casemiro, Diana Monteiro Quirino, Maria Angélica Andreotti Diniz, Rosalina Aparecida Partezani Rodrigues, Sofia Cristina Iost Pavarini, Aline Cristina Martins Gratão
OBJECTIVE: to analyze the effects of health education on both cognition and depressive/anxiety symptoms in the elderly with Mild Cognitive Impairment (MCI). METHOD: this is a randomized and controlled clinical trial. Participants (n=22) were recruited from a specialized outpatient clinic, and assigned into two groups: a Health Education Group (HEG) (n=10) and a Control Group (CG) (n=12). The participants were evaluated before and after the intervention, which was composed of classes and dynamics...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791626/aging-and-quality-of-life-of-elderly-people-in-rural-areas
#15
Juliana Ladeira Garbaccio, Luís Antônio Batista Tonaco, Wilson Goulart Estêvão, Bárbara Jacome Barcelos
OBJECTIVE: To evaluate the quality of life and health of elderly in rural areas of Minas Gerais State's center-west. METHOD: Cross-sectional study, in four municipalities of Minas Gerais State, by interviewing elderly people. Associations between socio-demographic and quality of life variables were tested, separated into "satisfactory"/"unsatisfactory" with values from the median of positive answers. It was used the chi-square test, Fisher's test and regression...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791460/are-saving-appearance-responses-typical-communication-patterns-in-alzheimer-s-disease
#16
Masateru Matsushita, Yusuke Yatabe, Asuka Koyama, Akiko Katsuya, Daisuke Ijichi, Yusuke Miyagawa, Hiroto Ikezaki, Noboru Furukawa, Manabu Ikeda, Mamoru Hashimoto
INTRODUCTION: To keep up appearances, people with dementia sometimes pretend to know the correct answer, as seen during administration of neuropsychological tests such as the Mini-Mental State Examination (MMSE). These saving appearance responses (SARs) of people with dementia often lead to caregivers and/or medical staff underestimating the severity of dementia and impede proper early initiation of treatment. However, most descriptions of SARs are based on empirical knowledge of clinicians...
2018: PloS One
https://www.readbyqxmd.com/read/29791452/validity-and-reliability-of-two-alternate-versions-of-the-montreal-cognitive-assessment-hong-kong-version-for-screening-of-mild-neurocognitive-disorder
#17
Adrian Wong, Stanley Yiu, Ziad Nasreddine, Kam-Tat Leung, Alexander Lau, Yannie O Y Soo, Lawrence Ka-Sing Wong, Vincent Mok
OBJECTIVE: Repeated testing using the Montreal Cognitive Assessment (MoCA) increases risks for practice effects which may bias measurements of cognitive change. The objective of this study is to develop two alternate versions of the MoCA (Hong Kong version; HK-MoCA) and to investigate the validity and reliability of the alternate versions in patients with DSM-5 Mild Neurocognitive Disorder (Mild NCD) and cognitively healthy controls. METHODS: Concurrent validity and inter-scale agreement were examined by Pearson correlation of the total scores between the original and alternate versions and the Bland-Altman Method...
2018: PloS One
https://www.readbyqxmd.com/read/29791045/person-specific-validation-and-testing-of-functional-relations-in-cognitive-behavioural-case-formulation-guidelines-and-options
#18
Gregory H Mumma, Andrew J Marshall, Cortney Mauer
Although a number of manuals describe how to develop a cognitive-behavioural case formulation (CBCF) to assist the clinician in developing and implementing tailored CB treatment for complex or comorbid cases, methods to evaluate and test functional hypotheses in the formulation for a particular case are not widely known or used. Thus, formulation-based, tailored treatments for such cases are likely to be guided by case formulations of uncertain validity. The present article presents guidelines and choices available to the clinical trainee, researcher, or practitioner planning to use a person-specific (PS) approach to testing CBCF hypotheses about functional relations between triggers, cognitions, and distress or dysfunction...
May 23, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29790971/brain-activity-associated-with-attention-deficits-following-chemotherapy-for-childhood-acute-lymphoblastic-leukemia
#19
Slim Fellah, Yin T Cheung, Matthew A Scoggins, Ping Zou, Noah D Sabin, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Robert J Ogg, Kevin R Krull
Background: The impact of contemporary chemotherapy treatment for childhood acute lymphoblastic leukemia on central nervous system activity is not fully appreciated. Methods: Neurocognitive testing and functional magnetic resonance imaging (fMRI) were obtained in 165 survivors five or more years postdiagnosis (average age = 14.4 years, 7.7 years from diagnosis, 51.5% males). Chemotherapy exposure was measured as serum concentration of methotrexate following high-dose intravenous injection...
May 21, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29790690/validation-of-the-portuguese-version-of-addenbrooke-s-cognitive-examination-iii-in-mild-cognitive-impairment-and-dementia
#20
Bruno Peixoto, Milene Machado, Patricia Rocha, Carla Macedo, António Machado, Élia Baeta, Gerly Gonçalves, Paulo Pimentel, Emanuela Lopes, Luis Monteiro
BACKGROUND: Cognitive assessment is central to the diagnosis of cognitive impairment and dementia, and it should be performed in all patients in the early stages of the disease. Recently, the 3rd version of Addenbrooke's Cognitive Examination (ACE-III) has been developed in order to improve the previous versions. OBJECTIVES: The aim of this study was to determine the psychometric properties of the Portuguese version of ACE-III, namely: reliability and discriminative validity (sensitivity and specificity) in the identification of mild cognitive impairment (MCI) and dementia, in comparison to other neuropsychological screening tests, as well as to establish its concurrent and divergent validity...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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