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https://www.readbyqxmd.com/read/28445721/nacho-mediates-nicotinic-acetylcholine-receptor-function-throughout-the-brain
#1
Jose A Matta, Shenyan Gu, Weston B Davini, Brian Lord, Edward R Siuda, Anthony W Harrington, David S Bredt
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine. Neuronal nAChRs derive from combinations of α and β subunits, whose assembly is tightly regulated. NACHO was recently identified as a chaperone for α7-type nAChRs. Here, we find NACHO mediates assembly of all major classes of presynaptic and postsynaptic nAChR tested. NACHO acts at early intracellular stages of nAChR subunit assembly and then synergizes with RIC-3 for receptor surface expression...
April 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28445547/correction-an-automated-experimenter-free-method-for-the-standardised-operant-cognitive-testing-of-rats
#2
Marion Rivalan, Humaira Munawar, Anna Fuchs, York Winter
[This corrects the article DOI: 10.1371/journal.pone.0169476.].
2017: PloS One
https://www.readbyqxmd.com/read/28445438/reliability-and-validity-of-the-medical-outcomes-study-short-form-12-version-2-sf-12v2-in-adults-with-non-cancer-pain
#3
Corey J Hayes, Naleen Raj Bhandari, Niranjan Kathe, Nalin Payakachat
Limited evidence exists on how non-cancer pain (NCP) affects an individual's health-related quality of life (HRQoL). This study aimed to validate the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2), a generic measure of HRQoL, in a NCP cohort using the Medical Expenditure Panel Survey Longitudinal Files. The SF Mental Component Summary (MCS12) and SF Physical Component Summary (PCS12) were tested for reliability (internal consistency and test-retest reliability) and validity (construct: convergent and discriminant; criterion: concurrent and predictive)...
April 26, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28445276/correlation-between-prefrontal-striatal-pathway-impairment-and-cognitive-impairment-in-patients-with-leukoaraiosis
#4
Shuangkun Wang, Junliang Yuan, Xiaojuan Guo, Leilei Teng, Hua Jiang, Hua Gu, Wenli Hu, Tao Jiang
Our study aimed to investigate the changes of white matter microstructure of cortico-subcortical pathways using diffusion tensor imaging (DTI), and to explore the relationship between abnormal parameters of DTI and cognitive function underlying in patients with leukoaraiosis (LA).A total of 42 patients with LA and 42 age- and sex-matched healthy controls were recruited from Beijing Chaoyang Hospital, Capital Medical University between January 2012 and December 2012. All the subjects underwent scans of conventional magnetic resonance imaging and DTI, and a comprehensive neuropsychological battery was utilized...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445261/behavior-characteristics-of-the-attention-network-of-military-personnel-with-high-and-low-trait-anxiety
#5
Yu Pan, Wenpeng Cai, Wei Dong, Jie Xiao, Jin Yan, Qi Cheng
Converging evidence reveals significant increase in both state anxiety and trait anxiety during the past 2 decades among military servicemen and servicewomen in China. In the present study, we employed the Chinese version of the State-trait Anxiety Inventory (STAI) to examine trait and state anxiety in Chinese military servicemen and servicewomen. We further evaluated orienting, alerting and execution inhibition using the attention network test.Healthy military servicemen and servicewomen were recruited for the present study...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445196/the-use-of-a-fresh-tissue-cadaver-model-for-the-instruction-of-dermatological-procedures-a-laboratory-study-for-training-medical-students
#6
Jose A Cervantes, Collin M Costello, Melody Maarouf, Hilary C McCrary, Nathalie C Zeitouni
BACKGROUND: A realistic model for the instruction of basic dermatologic procedural skills was developed, while simultaneously increasing medical student exposure to the field of dermatology. OBJECTIVE: The primary purpose of the authors' study was to evaluate the utilization of a fresh-tissue cadaver model (FTCM) as a method for the instruction of common dermatologic procedures. The authors' secondary aim was to assess students' perceived clinical skills and overall perception of the field of dermatology after the lab...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28445172/telehealth-intensive-care-unit-nurse-surveillance-of-sepsis
#7
Teresa A Rincon, E LaVerne Manos, Janet D Pierce
The purpose of this article is to describe the usability and human factors engineering standards used in development of a sepsis alert known as the sepsis prompt. Sensory processing, cognitive processing, signal detection, criterion response, and user satisfaction were evaluated with controlled user testing and critical incident response techniques. Nurses reported that the sepsis prompt was visible and distinct, making it easily detectable. The prompt provided a clear response mechanism and adequately balanced the number of false alerts with the likelihood of misses...
April 25, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28444767/the-dual-orexin-receptor-antagonist-dora-22-lowers-histamine-levels-in-the-lateral-hypothalamus-and-prefrontal-cortex-without-lowering-hippocampal-acetylcholine
#8
Lihang Leon Yao, Andres Ramirez, Anthony J Roecker, Steven Fox, Jason Uslaner, Sean M Smith, Robert Hodgson, Paul J Coleman, John J Renger, Christopher J Winrow, Anthony L Gotter
Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non-restorative sleep. The therapeutic standard of care for this condition is treatment with gamma-aminobutyric acid (GABA)A receptor modulators, which promote sleep but are associated with a panoply of side effects, including cognitive and memory impairment. Dual orexin receptor antagonists (DORAs) have recently emerged as an alternative therapeutic approach that acts via a distinct and more selective wake-attenuating mechanism with the potential to be associated with milder side effects...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28444554/relationships-between-environmental-factors-and-participation-in-adults-with-traumatic-brain-injury-stroke-and-spinal-cord-injury-a-cross-sectional-multi-center-study
#9
Alex W K Wong, Sheryl Ng, Jessica Dashner, M Carolyn Baum, Joy Hammel, Susan Magasi, Jin-Shei Lai, Noelle E Carlozzi, David S Tulsky, Ana Miskovic, Arielle Goldsmith, Allen W Heinemann
PURPOSE: To develop and evaluate a model of environmental factors-participation relationships for persons with traumatic brain injury (TBI), stroke, and spinal cord injury (SCI), and test whether this model differed across three diagnostic groups, as well as other demographic and clinical characteristics. METHODS: A cross-sectional observational study included 545 community-dwelling adults with neurological disorders (TBI = 166; stroke = 189; SCI = 190) recruited at three academic medical centers...
April 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28444507/heuristics-and-bias-in-rectal-surgery
#10
Ewan MacDermid, Christopher J Young, Susan J Moug, Robert G Anderson, Heather L Shepherd
PURPOSE: Deciding to defunction after anterior resection can be difficult, requiring cognitive tools or heuristics. From our previous work, increasing age and risk-taking propensity were identified as heuristic biases for surgeons in Australia and New Zealand (CSSANZ), and inversely proportional to the likelihood of creating defunctioning stomas. We aimed to assess these factors for colorectal surgeons in the British Isles, and identify other potential biases. METHODS: The Association of Coloproctology of Great Britain and Ireland (ACPGBI) was invited to complete an online survey...
April 25, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28444457/social-cognition-and-idiopathic-isolated-cervical-dystonia
#11
Kristína Czekóová, Petra Zemánková, Daniel J Shaw, Martin Bareš
For a long time, cervical dystonia (CD) has been characterised only by disturbances in motor functioning. Despite accumulating evidence for symptomatology in various non-motor domains, to date no study has investigated social cognition in CD. The aim of this study was to compare performance of CD patients and healthy controls in neurocognitive and socio-cognitive domain. Twenty-five non-depressed patients with CD and 26 healthy controls underwent neuropsychological testing. This involved assessment of cognitive status (general intellect, verbal memory, and executive function), and socio-cognitive functions using a Theory of mind task and self-report on empathy and emotion regulation...
April 25, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28444446/comparison-of-the-clinical-and-cognitive-features-of-genetically-positive-als-patients-from-the-largest-tertiary-center-in-serbia
#12
Ivan V Marjanović, Biljana Selak-Djokić, Stojan Perić, Milena Janković, Vladimir Arsenijević, Ivana Basta, Dragana Lavrnić, Elka Stefanova, Zorica Stević
Discovering novel mutations in C9orf72, FUS, ANG, and TDP-43 genes in ALS patients arises necessities for better clinical characterizations of these subjects. The aim is to determine clinical and cognitive profile of genetically positive Serbian ALS patients. 241 ALS patients were included in the study (17 familiar and 224 apparently sporadic). The following genes were analyzed: SOD1, C9orf72, ANG, FUS, and TDP-43. An extensive battery of classic neuropsychological tests was used in 27 ALS patients (22 SOD1 positive and 5 SOD1 negative) and 82 healthy controls (HCs)...
April 25, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28444394/tissue-specific-dissociation-of-diurnal-transcriptome-rhythms-during-sleep-restriction-in-mice
#13
Jana Husse, Jana-Thabea Kiehn, Johanna L Barclay, Nadine Naujokat, Judit Meyer-Kovac, Hendrik Lehnert, Henrik Oster
Study objectives: Shortened or mistimed sleep affects metabolic homeostasis, which may in part be mediated by dysregulation of endogenous circadian clocks. In this study, we assessed the contribution of sleep disruption to metabolic dysregulation by analysing diurnal transcriptome regulation in metabolic tissues of mice subjected to a sleep restriction paradigm. Methods: Male mice were subjected to 2x5 days of sleep restriction (SR) with enforced waking during the first six hours of the light phase...
April 24, 2017: Sleep
https://www.readbyqxmd.com/read/28444373/plasticity-of-the-right-lateralized-cognitive-reserve-network-in-ageing
#14
Méadhbh B Brosnan, Giorgia Demaria, Anders Petersen, Paul M Dockree, Ian H Robertson, Iris Wiegand
Cognitive reserve (CR) is the phenomenon where older adults with more cognitively stimulating environments show less age-related cognitive decline. The right-lateralized fronto-parietal network has been proposed to significantly contribute to CR and visual attention in ageing. In this study we tested whether plasticity of this network may be harnessed in ageing.We assessed CR and parameters of visual attention capacity in older adults. Transcranial direct current stimulation (tDCS) was employed to increase right fronto-parietal activity during a lateralized whole-report task...
April 24, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28444303/testing-comparability-between-retrospective-life-history-data-and-prospective-birth-cohort-study-data
#15
Stephen Jivraj, Alissa Goodman, George B Ploubidis, Cesar de Oliveira
Objectives: To determine whether comparable prospective and retrospective data present the same association between childhood and life course exposures and mid-life wellbeing. Method: Prospective data is taken from the 1958 UK National Child Development Study at age 50 in 2008 and earlier sweeps (n = 8,033). Retrospective data is taken from the English Longitudinal Study of Ageing at ages 50-55 from a life history interview in 2007 (n = 921). Results: There is a high degree of similarity in the direction of association between childhood exposures that have been prospectively collected in National Child Development Study and retrospectively collected in English Longitudinal Study of Ageing and wellbeing outcomes in mid-life...
April 21, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28444253/fear-of-falling-in-people-with-multiple-sclerosis-which-clinical-characteristics-are-important
#16
Hanan Khalil, Alham Al-Shorman, Khalid El-Salem, Nour Abdo, Alia A Alghwiri, Aseel Aburub, Sarah Shalabi, Firas Al-Mustafa
Background.: Fear of falling (FOF) is an important risk indicator for health related outcomes and quality of life in patients with multiple sclerosis (MS). However, factors associated with FOF in MS are not well investigated. Objectives.: This study was done to explore predictors of FOF in this population. Methods.: Seventy relapsing remitting patients with MS were evaluated. FOF was assessed using Fall Efficacy Scale-International (FES-I)...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28444123/a-comparison-of-four-computerized-neurocognitive-assessment-tools%C3%A2-to-a-traditional-neuropsychological-test-battery-in-service-members-with-and-without-mild-traumatic-brain-injury
#17
Wesley R Cole, Jacques P Arrieux, Brian J Ivins, Karen A Schwab, Felicia M Qashu
Objective: Computerized neurocognitive assessment tools (NCATS) are often used as a screening tool to identify cognitive deficits after mild traumatic brain injury (mTBI). However, differing methodology across studies renders it difficult to identify a consensus regarding the validity of NCATs. Thus, studies where multiple NCATs are administered in the same sample using the same methodology are warranted. Method: We investigated the validity of four NCATs: the ANAM4, CNS-VS, CogState, and ImPACT...
April 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28444072/chronic-obstructive-pulmonary-disease-exacerbation-in-the-intensive-care-unit-clinical-functional-and-quality-of-life-at-discharge-and-3-months-of-follow-up
#18
Renata Cristina Teixeira Pinto Viana, Mariangela Pimentel Pincelli, Emílio Pizzichini, André Pacheco Silva, Joice Manes, Tatiana Dias Marconi, Leila John Marques Steidle
Objective: The purpose of this study was to evaluate the clinical/functional aspects and quality of life of chronic obstructive pulmonary disease patients who were discharged after an intensive care unit admission for acute respiratory failure. Methods: This prospective study included chronic obstructive pulmonary disease patients who were admitted to two intensive care units between December of 2010 and August of 2011 and evaluated over three visits after discharge...
January 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28443616/effects-of-extended-cannabis-abstinence-on-cognitive-outcomes-in-cannabis-dependent-patients-with-schizophrenia-versus-non-psychiatric-controls
#19
Rachel A Rabin, Mera S Barr, Michelle S Goodman, Yarissa Herman, Konstantine K Zakzanis, Stephen J Kish, Michael Kiang, Gary Remington, Tony P George
Cross-sectional studies of the effects of cannabis on cognition in schizophrenia have produced mixed results. Heavy and persistent cannabis use in schizophrenia is a common clinical problem, and effects of controlled abstinence from cannabis in these patients have not been carefully evaluated. The present study sought to determine the effects of cannabis abstinence on cognition in patients with schizophrenia and co-occurring cannabis dependence. We utilized a 28-day cannabis abstinence paradigm to investigate the state-dependent effects of cannabis on select cognitive outcomes in cannabis dependent patients with schizophrenia and non-psychiatric controls...
April 26, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28443560/advances-in-nutrition-of-the-newborn-infant
#20
REVIEW
Jane E Harding, Barbara E Cormack, Tanith Alexander, Jane M Alsweiler, Frank H Bloomfield
Nutrition of newborn infants, particularly of those born preterm, has advanced substantially in recent years. Extremely preterm infants have high nutrient demands that are challenging to meet, such that growth faltering is common. Inadequate growth is associated with poor neurodevelopmental outcomes, and although improved early growth is associated with better cognitive outcomes, there might be a trade-off in terms of worse metabolic outcomes, although the contribution of early nutrition to these associations is not established...
April 22, 2017: Lancet
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