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Palliative chemotherapy

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https://www.readbyqxmd.com/read/29333025/primary-leiomyosarcoma-of-breast-presenting-with-metastasis-an-atypical-presentation-with-dismal-prognosis
#1
Garima Singh, Deepti Sharma, Surbhi Goyal
Leiomyosarcoma is an extremely uncommon subtype of breast sarcoma, with <50 cases reported in the English literature till date. Patients usually present at an early stage and follow an indolent course. We reported an unusual case of leiomyosarcoma of breast in a post -menopausal female,presented with right side breast lump and pain right side hip. Histomorphological evaluation and immunohistochemistry confirmed the diagnosis. The patient received palliative radiotherapy 20 Gy in 5 fractions to right iliac bone and was started on chemotherapy comprising of docetaxel and epirubicin...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332329/modified-3-week-schedule-of-gemcitabine-plus-cisplatin-for-non-small-cell-lung-cancer-treatment
#2
Antonello Veccia, Viviana Murgia, Mariachiara Dipasquale, Orazio Caffo
PURPOSE: Gemcitabine-cisplatin combination is one of the most used schedules for non small cell lung cancer (NSCLC). Aiming to enhance dose intensity and reduce toxicity, the original 4-week schedule was modified or transformed into a 3-week schedule. The purpose of this study was to report the efficacy and tolerability of a modified 3-week regimen of gemcitabine-cisplatin. METHODS: Our patients were treated with gemcitabine (1000 mg7sol;m2) on days 1, 8 and cisplatin on day 8 (75-100 mg/m2)...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29326401/efficacy-and-tolerability-of-trastuzumab-emtansine-in-advanced-human-epidermal-growth-factor-receptor-2-positive-breast-cancer
#3
W Yeo, M Y Luk, I S Soong, T Ys Yuen, T Y Ng, F Kf Mo, K Chan, S Y Wong, J Tsang, C Leung, J Js Suen, R Kc Ngan
INTRODUCTION: The management of human epidermal growth factor receptor 2 (HER2)-positive breast cancer has changed dramatically with the introduction and widespread use of HER2-targeted therapies. There is, however, relatively limited real-world information about the effectiveness and safety of trastuzumab emtansine (T-DM1) in the Hong Kong Chinese patients. We assessed the efficacy and toxicity profiles among local patients with HER2-positive advanced breast cancer who had received T-DM1 therapy in the second-line setting and beyond...
January 12, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29326400/treatment-of-cutaneous-angiosarcoma-of-the-scalp-and-face-in-the-chinese-patients-local-experience-at-a-regional-hospital-in-hong-kong
#4
T L Chow, W Wy Kwan, C K Kwan
INTRODUCTION: Angiosarcoma is a rare aggressive sarcoma that occurs mostly in the skin of the head and neck in the elderly population. The optimal management is dubious and most studies are from Caucasian populations. We aimed to find out the treatment and outcome of this disease in Chinese patients. METHODS: Data of patients with histopathologically verified cutaneous angiosarcoma of the head and neck during December 1997 to September 2016 were retrieved from our cancer registry...
January 12, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29324681/ppoma-review-epidemiology-aetiopathogenesis-prognosis-and-treatment
#5
REVIEW
Thais Ligiero Braga, Ralph Santos-Oliveira
Generally, pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma) is classified as a rare tumor, and may occur sporadically or be associated in families or with multiple endocrine neoplasia type 1 (NEM 1). It grows slowly, reaching large dimensions at the time of diagnosis and the symptomatology is fundamentally due to the mass effect, causing either non-specific abdominal pain or symptoms suggestive of obstruction of the pancreatic or biliary duct. Therefore, when detected, they are usually malignant, with metastases mainly in the liver...
January 11, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29320420/locally-advanced-pancreatic-cancer-a-review-of-local-ablative-therapies
#6
REVIEW
Alette Ruarus, Laurien Vroomen, Robbert Puijk, Hester Scheffer, Martijn Meijerink
Pancreatic cancer is typically characterized by its aggressive tumor growth and dismal prognosis. Approximately 30% of patients with pancreatic cancer present with locally advanced disease, broadly defined as having a tumor-to-artery interface >180°, having an unreconstructable portal vein or superior mesenteric vein and no signs of metastatic disease. These patients are currently designated to palliative systemic chemotherapy, though median overall survival remains poor (approximately 11 months). Therefore, several innovative local therapies have been investigated as new treatment options for locally advanced pancreatic cancer (LAPC)...
January 10, 2018: Cancers
https://www.readbyqxmd.com/read/29319742/risk-prediction-and-impaired-tactile-sensory-perception-among-cancer-patients-during-chemotherapy
#7
Ana Carolina Lima Ramos Cardoso, Diego Dias de Araújo, Tânia Couto Machado Chianca
OBJECTIVES: to estimate the prevalence of impaired tactile sensory perception, identify risk factors, and establish a risk prediction model among adult patients receiving antineoplastic chemotherapy. METHOD: historical cohort study based on information obtained from the medical files of 127 patients cared for in the cancer unit of a private hospital in a city in Minas Gerais, Brazil. Data were analyzed using descriptive and bivariate statistics, with survival and multivariate analysis by Cox regression...
January 8, 2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29319480/the-impact-of-patient-disease-and-treatment-related-factors-on-survival-in-patients-with-adrenocortical-carcinoma
#8
Nahid Punjani, Roderick Clark, Jonathan Izawa, Joseph Chin, Stephen E Pautler, Nicholas Power
INTRODUCTION: Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine tumour. Most present with advanced disease and have poor prognosis. Optimal treatment includes complete surgical resection. There is limited evidence for the efficacy of chemotherapy and radiation at different stages in this disease. There remain many inconsistencies with respect to diagnosis and workup. There is a lack of uniform guideline recommendations and consensus data. METHODS: We performed a retrospective chart review of all patients at London Health Sciences Centre between 1990 and 2015 using ICD coding...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29318756/loss-of-skeletal-muscle-during-systemic-chemotherapy-is-prognostic-of-poor-survival-in-patients-with-foregut-cancer
#9
Louise E Daly, Éadaoin B Ní Bhuachalla, Derek G Power, Samantha J Cushen, Karl James, Aoife M Ryan
BACKGROUND: Malnutrition, weight loss, and muscle wasting are common in patients with foregut cancers (oesophagus, stomach, pancreas, liver, and bile ducts) and are associated with adverse clinical outcomes. However, little is known about the changes in body composition that occur in these patients during chemotherapy and its impacts clinical outcomes. PATIENTS AND METHODS: A prospective study of adult foregut cancer patients undergoing chemotherapy between 2012 and 2016 was conducted...
January 9, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29313655/lung-cancer-management
#10
Timothy F Mott
Lung cancer management that is individualized for age, comorbidities, cancer type, cancer stage, and patient preference has long been a cornerstone of management. New to this realm of individualized management are the emerging biologic therapies, immunotherapies, and targeted therapies for non-small-cell lung cancer provided by advances in genetics and molecular medicine. These techniques have led to a new field of precision medicine based on the unique molecular characteristics of a specific patient and the specific cancer...
January 2018: FP Essentials
https://www.readbyqxmd.com/read/29313129/characteristics-and-care-pathways-of-advanced-cancer-patients-in-a-palliative-supportive-care-unit-and-an-oncological-ward
#11
Sebastiano Mercadante, Paolo Marchetti, Claudio Adile, Amanda Caruselli, Patrizia Ferrera, Andrea Costanzi, Alessandra Casuccio
BACKGROUND: A supportive palliative care unit (SPCU) may have a positive impact on patients' care. The aim of this study was to compare the pattern of patients admitted to a specialized SPCU and to a traditional oncologic ward (OW) in a consecutive sample of advanced cancer patients. METHODS: Data on patients demographics, reasons for and kind of admission, care-giver, anticancer treatments, being on/off treatment or uncertain, origin setting, who proposed hospital admission, the use of opioids, and hospitalization were gathered...
January 8, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29305245/home-parenteral-nutrition-increases-fat-free-mass-in-patients-with-incurable-gastrointestinal-cancer-results-of-a-randomized-controlled-trial
#12
Sine Roelsgaard Obling, Benedicte Vibjerg Wilson, Per Pfeiffer, Jens Kjeldsen
OBJECTIVE: Preventing loss of muscle mass and function is an enduring challenge in malnourished patients with incurable cancer. The benefit of supplemental home parenteral nutrition has not been firmly established. Our aim was to evaluate the effects of supplemental home parenteral nutrition, the primary endpoint being fat free mass (FFM) and secondary: muscle function, quality of life and overall survival. DESIGN AND METHODS: In a single centre open-label randomised controlled trial, patients with incurable gastrointestinal cancer, nutritionally at risk, were randomly assigned to either; a) best practice nutritional care and dietetic counselling (non-sHPN) or b) dietetic counselling and supplemental home parenteral nutrition (sHPN group)...
December 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29299514/percutaneous-gastrostomy-site-metastasis-from-head-and-neck-tumors-a-single-institution-case-series
#13
James S Metkus, David Cognetti, Joseph Curry
Objectives: Head and neck cancer (HNC) patients often require percutaneous gastrostomy (PEG) tube placement due to malnutrition and dysphagia. While beneficial, PEG tube placement can cause a rare but reportable complication of metastasis of the original tumor to the gastrostomy exit site. The objectives of this case series were to present HNC patients at a single institution that developed PEG tube metastases, their subsequent treatment, and review of the literature for similar cases...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29299375/radiation-generates-an-abscopal-response-and-complete-resolution-of-metastatic-squamous-cell-carcinoma-of-the-anal-canal-a-case-report
#14
Moss Bruton Joe, Julian J Lum, Peter H Watson, R Petter Tonseth, John Paul McGhie, Pauline T Truong
The abscopal effect is a rare phenomenon in the setting of radiation therapy (RT) for metastatic cancer where tumor regression occurs distant from the site of treatment. A proposed mechanism of the abscopal effect is the activation of a systemic antitumor immune response by localized RT. We report the first case, to our knowledge, of the abscopal effect in squamous carcinoma of the anal canal with metastases to pelvic lymph nodes, liver and bone. After palliative RT to the pelvis with sensitizing chemotherapy, complete response was observed not only in the primary tumor but also in bone and multiple liver metastases at 4 months after treatment, an effect that remained durable at 4-year follow-up...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29298626/systemic-anticancer-therapy-in-the-last-30-days-of-life-retrospective-audit-from-an-australian-regional-cancer-centre
#15
Peter J Gilbar, Ian McPherson, Genevieve G Aisthorpe, Srinivas Kondalsamy-Chennakes
Background Cessation of chemotherapy at an appropriate time is an important component of good quality palliative care. Published studies looking at administration of chemotherapy at the end of life vary widely. Objective To retrospectively determine the rate of death occurring within 14 and 30 days of chemotherapy and use this to benchmark against other cancer centres as a quality of care measure. Method All adult patients who received systemic anticancer therapy for solid tumours and haematological malignancies at an Australian Regional Cancer Centre between 2011 and 2015 were included...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29286911/primary-breast-angiosarcoma-a-single-institution-experience-from-a-tertiary-cancer-center-in-south%C3%A2-india
#16
D Lokanatha, Abhishek Anand, K C Lakshmaiah, K Govind Babu, Linu Abraham Jacob, M C Suresh Babu, K N Lokesh, A H Rudresha, L K Rajeev, Smitha C Saldanha, G V Giri, Deepak Koppaka, Rekha V Kumar
INTRODUCTION: Primary angiosarcoma of the breast is a rare entity with incidence of less than 0.05% of all malignant breast neoplasms. It occurs in young females without any associated risk factors. The tumor behaves aggressively and has a poor prognosis compared to invasive ductal carcinoma. METHOD: It was a retrospective observational study done at a tertiary cancer center from January 2012 to December 2016. The medical records of patients diagnosed with primary breast angiosarcoma were reviewed for the study...
December 28, 2017: Breast Disease
https://www.readbyqxmd.com/read/29285376/neoadjuvant-treatment-with-cisplatin-and-s-1-in-elderly-patients-with-oesophagogastric-adenocarcinoma-and-locoregional-disease-two-case-reports-and-review-of-the-literature
#17
Caspar Franck, Ali Canbay, Peter Malfertheiner, Marino Venerito
Perioperative platinum/fluoropyrimidine-based chemotherapy is the therapeutic standard for oesophagogastric cancer (OAC) patients with locoregional disease. The preoperative condition directly affects postoperative prognosis; thus, particularly for elderly patients, a perioperative regimen with a favourable side effect profile is highly desirable. In the palliative setting, the combination of cisplatin and S-1 (Cis/S-1) was found to be as effective as cisplatin/5-fluorouracil, but with a more favourable side effect profile...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285039/cyclophosphamide-methotrexate-and-5-fluorouracil-as-palliative-treatment-for-heavily-pretreated-patients-with-metastatic-breast-cancer-a-multicenter-retrospective-analysis
#18
Jin Hyun Park, Seock-Ah Im, Ja Min Byun, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Hee-Jun Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Do Youn Oh, Tae-You Kim
Purpose: This study aimed to evaluate the efficacy and safety of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy beyond standard treatment for anthracycline- and taxane-pretreated metastatic breast cancer (MBC). Methods: We consecutively enrolled 158 MBC patients who underwent CMF chemotherapy in a palliative setting at two academic hospitals in Korea between 2002 and 2016. Results: The median age of the 158 enrolled patients was 51 years (range, 30-77 years)...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29279709/long-term-survival-with-regorafenib-in-kras-mutated-metastatic-rectal-cancer
#19
Marie-Laure Amram, Xavier Montet, Arnaud D Roth
Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer progressing on standard therapies. Here, we describe the clinical history of a 63-year-old male patient who was treated with regorafenib in the pivotal CORRECT trial. The patient was initially diagnosed in November 2008 with nonmetastatic KRAS-mutated (exon 2, codon 12) rectal cancer. He underwent successful surgery and was treated with 5 cycles of adjuvant chemotherapy...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29279492/cyberknife-stereotactic-radiosurgery-for-cholangiocarcinoma
#20
Yuko Harada, Shinichiro Miyazaki
Cholangiocarcinoma is a devastating cancer with a poor prognosis. Patients are often diagnosed at the advanced stage, and curative surgery is impossible. Radiation therapy is used for cases of advanced cancer. A 50-year-old woman with stage IVb intrahepatic cholangiocarcinoma was diagnosed with unresectable cancer, and had chemotherapy; however, the disease progressed. CyberKnife radiosurgery was performed, which was able to control the symptoms of liver failure and prolong her life. Her symptoms, which included jaundice, ascites, and edema disappeared and her tumor markers became normal...
December 27, 2017: Internal Medicine
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