Jan Miroslav Hartinger, Danica Michaličková, Eliška Dvořáčková, Karolína Hronová, Elke H J Krekels, Barbora Szonowská, Vladimíra Bednářová, Hana Benáková, Gabriela Kroneislová, Jan Závora, Vladimír Tesař, Ondřej Slanař
Peritonitis is a limiting complication of peritoneal dialysis, which is treated by intraperitoneal administration of antibiotics. Various dosing strategies are recommended for intraperitoneally administered vancomycin, which leads to large differences in intraperitoneal vancomycin exposure. Based on data from therapeutic drug monitoring, we developed the first-ever population pharmacokinetic model for intraperitoneally administered vancomycin to evaluate intraperitoneal and plasma exposure after dosing schedules recommended by the International Society for Peritoneal Dialysis...
May 2, 2023: Pharmaceutics