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P Sutha, V E Jayanthi
Birth defect-related demise is mainly due to congenital heart defects. In the earlier stage of pregnancy, fetus problem can be identified by finding information about the fetus to avoid stillbirths. The gold standard used to monitor the health status of the fetus is by Cardiotachography(CTG), cannot be used for long durations and continuous monitoring. There is a need for continuous and long duration monitoring of fetal ECG signals to study the progressive health status of the fetus using portable devices. The non-invasive method of electrocardiogram recording is one of the best method used to diagnose fetal cardiac problem rather than the invasive methods...
December 8, 2017: Journal of Medical Systems
Sucheta, Sumit Tahlan, Prabhakar Kumar Verma
Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. However, owing to the swift development of new molecules containing this nucleus, many research reports have been generated in a brief span of time...
December 8, 2017: Chemistry Central Journal
Barbara Domańska, Oliver Stumpp, Steven Poon, Serkan Oray, Irina Mountian, Clovis Pichon
INTRODUCTION: We incorporated patient feedback from human factors studies (HFS) in the patient-centric design and validation of ava®, an electromechanical device (e-Device) for self-injecting the anti-tumor necrosis factor certolizumab pegol (CZP). METHODS: Healthcare professionals, caregivers, healthy volunteers, and patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or Crohn's disease participated in 11 formative HFS to optimize the e-Device design through intended user feedback; nine studies involved simulated injections...
December 8, 2017: Advances in Therapy
Ana I S Moretti, Jessyca C Pavanelli, Patrícia Nolasco, Matthias S Leisegang, Leonardo Y Tanaka, Carolina G Fernandes, João Wosniak, Daniela Kajihara, Matheus H Dias, Denise C Fernandes, Hanjoong Jo, Ngoc-Vinh Tran, Ingo Ebersberger, Ralf P Brandes, Diego Bonatto, Francisco R M Laurindo
Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox protein folding and cell-surface thiol-redox control of thrombosis and vascular remodeling. The family prototype PDIA1 regulates NADPH oxidase signaling and cytoskeleton organization, however the related underlying mechanisms are unclear. Here we show that genes encoding human PDIA1 and its two paralogs PDIA8 and PDIA2 are each flanked by genes encoding Rho guanine-dissociation inhibitors (GDI), known regulators of RhoGTPases/cytoskeleton...
December 8, 2017: Scientific Reports
Deep Choudhuri, Srivilliputhur G Srinivasan, Mark A Gibson, Yufeng Zheng, David L Jaeger, Hamish L Fraser, Rajarshi Banerjee
Several recent papers report spectacular, and unexpected, order of magnitude improvement in creep life of alloys upon adding small amounts of elements like zinc. This microalloying effect raises fundamental questions regarding creep deformation mechanisms. Here, using atomic-scale characterization and first principles calculations, we attribute the 600% increase in creep life in a prototypical Mg-rare earth (RE)-Zn alloy to multiple mechanisms caused by RE-Zn bonding-stabilization of a large volume fraction of strengthening precipitates on slip planes, increase in vacancy diffusion barrier, reduction in activated cross-slip, and enhancement of covalent character and bond strength around Zn solutes along the c-axis of Mg...
December 8, 2017: Nature Communications
Steven W de Taeye, Alba Torrents de la Peña, Andrea Vecchione, Enzo Scutigliani, Kwinten Sliepen, Judith A Burger, Patricia van der Woude, Anna Schorcht, Edith E Schermer, Marit J van Gils, Celia C LaBranche, David C Montefiori, Ian A Wilson, John P Moore, Andrew B Ward, Rogier W Sanders
To provide protective immunity against circulating primary HIV-1 strains, a vaccine most likely has to induce broadly neutralizing antibodies (bNAbs) to the HIV-1 envelope (Env) glycoprotein spike. Recombinant Env trimers such as the prototype BG505 SOSIP.664 that closely mimic the native Env spike can induce autologous neutralizing antibodies (NAbs) against relatively resistant (tier-2) primary viruses. Ideally, Env immunogens should present bNAb epitopes, but limit the presentation of immunodominant non-NAb epitopes that might induce off-target and potentially interfering responses...
December 8, 2017: Journal of Biological Chemistry
Austin Wilson, Hong Hua
State-of-the-art optical see-through head-mounted displays for augmented reality (AR) applications lack mutual occlusion capability, which refers to the ability to render correct light blocking relationship when merging digital and physical objects, such that the virtual views appear to be ghost-like and lack realistic appearance. In this paper, using off-the-shelf optical components, we present the design and prototype of an AR display which is capable of rendering per-pixel mutual occlusion. Our prototype utilizes a miniature organic light emitting display coupled with a liquid crystal on silicon type spatial light modulator to achieve an occlusion capable AR display offering a 30° diagonal field of view and an angular resolution of 1...
November 27, 2017: Optics Express
Ruijie Luo, Nan Hua, Yufang Yu, Yongtai Jin, Xiaoping Zheng, Bingkun Zhou
In recent years, to enlarge the single-mode fibers (SMFs) transmission capacity, researchers focused on the dimension of space, which is a new degree of freedom that is being considered for optical fiber communication beyond WDM. Space-division multiplexing (SDM), including mode-division multiplexing (MDM) using multimode fibers (MMFs) or few-mode fibers (FMFs), and core multiplexing using multicore fibers (MCFs), has attracted much recent attention. In an SDM system, high-density spatial channels are tightly packed into a single fiber, thus making crosstalk among cores or modes a critical challenge due to fiber imperfections, bending, and twisting...
November 27, 2017: Optics Express
Zhengxiong Zhu, Yan Li, Junjie Chen, Jianqiang Ma, Jiaru Chu
Deformable mirror (DM) used for intracavity compensation in high-power lasers should be able to withstand very high laser intensity. This paper proposes a water-cooled unimorph DM which can withstand the laser power up to 10 kW in thermal simulation. The proposed DM consists of an annular PZT layer and a circular Si layer which are glued together with edge clamped. All the 32 piezoelectric actuators are distributed around the correction area and on the front side of the DM. The cooling water flows through the back side of the DM and cools the mirror directly...
November 27, 2017: Optics Express
Jiajun Tian, Xiaolong Dong, Shimin Gao, Yong Yao
In this study, a novel fiber-optic, multipoint, laser-ultrasonic actuator based on fiber core-opened tapers (COTs) is proposed and demonstrated. The COTs were fabricated by splicing single-mode fibers using a standard fiber splicer. A COT can effectively couple part of a core mode into cladding modes, and the coupling ratio can be controlled by adjusting the taper length. Such characteristics are used to obtain a multipoint, laser-ultrasonic actuator with balanced signal strength by reasonably controlling the taper lengths of the COTs...
November 27, 2017: Optics Express
Yingying Dou, Nadine van Montfoort, Aniek van den Bosch, Robert A de Man, Gijs G Zom, Willem-Jan Krebber, Cornelis J M Melief, Sonja I Buschow, Andrea M Woltman
Background: Vaccination with Synthetic Long Peptides (SLP ®) is a promising new treatment strategy for chronic HBV (CHB). SLP can induce broad T cell responses for all HLA types. Here we investigated the ability of a prototype HBV-core (HBc)-sequence-derived SLP to boost HBV-specific T cells in CHB patients ex vivo. Methods: HBc-SLP was used to assess cross-presentation by monocyte-derived DC(moDC) and BDCA1+ blood myeloid DC (mDC) to engineered HBV-specific CD8+ T cells...
December 6, 2017: Journal of Infectious Diseases
Mohamed Reda Bouadjenek, Karin Verspoor
In the context of the bioCADDIE challenge addressing information retrieval of biomedical datasets, we propose a method for retrieval of biomedical data sets with heterogenous schemas through query reformulation. In particular, the method proposed transforms the initial query into a multi-field query that is then enriched with terms that are likely to occur in the relevant datasets. We compare and evaluate two query expansion strategies, one based on the Rocchio method and another based on a biomedical lexicon...
January 1, 2017: Database: the Journal of Biological Databases and Curation
Jin Jia, Tanli Xiong, Lili Zhao, Fulei Wang, Hong Liu, Renzong Hu, Jian Zhou, Weijia Zhou, Shaowei Chen
Probing competent electrocatalysts for hydrogen evolution reaction (HER) of water splitting is one of the most hopeful approach to front the energy and environmental crisis. Herein, we highlight ultrathin N-doped Mo2C nanosheets (N-Mo2C NSs) in the role of greatly efficient platinum-free-based electrocatalysts for the HER. The transformation of crystal phase and structure between MoO2 nanosheets with thickness of ~1.1 nm and N-Mo2C NSs with thickness of ~1.0 nm is detailed studied. Structural analyses make clear that the surfaces of the N-Mo2C NSs are absolutely encompassed of apical Mo atoms, hence affording an ideal catalyst prototype to expose the role of Mo atoms for the duration of HER catalysis...
December 8, 2017: ACS Nano
Miao Wang, Qing Hu, Qingshui Shi, Gongjun Yang, Fang Feng
1. Zhi-Zi-Da-Huang decoction (ZZDHD) has been widely used for the treatment of alcoholic jaundice, alcoholic liver disease and acute hepatitis in China for thousands of years. Conventionally decoctions are administered orally, after which the metabolism caused by the enzymes in intestinal bacteria may influence significantly on the curative effects or toxicity. 2. In this work, the comprehensive metabolic process of ZZDHD in intestinal bacteria was investigated reliably using high resolution HPLC-DAD-ESI-TOF/MS...
December 8, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Honggyu Kim, Patrick B Marshall, Kaveh Ahadi, Thomas E Mates, Evgeny Mikheev, Susanne Stemmer
The lattice response of a prototype Mott insulator, SmTiO_{3}, to hole doping is investigated with atomic-scale spatial resolution. SmTiO_{3} films are doped with Sr on the Sm site with concentrations that span the insulating and metallic sides of the filling-controlled Mott metal-insulator transition (MIT). The GdFeO_{3}-type distortions are investigated using an atomic resolution scanning transmission electron microscopy technique that can resolve small lattice distortions with picometer precision. We show that these distortions are gradually and uniformly reduced as the Sr concentration is increased without any phase separation...
November 3, 2017: Physical Review Letters
Shaoxiang Sheng, Jiang-Bin Wu, Xin Cong, Wenbin Li, Jian Gou, Qing Zhong, Peng Cheng, Ping-Heng Tan, Lan Chen, Kehui Wu
Combining ultrahigh sensitivity, spatial resolution, and the capability to resolve chemical information, tip-enhanced Raman spectroscopy (TERS) is a powerful tool to study molecules or nanoscale objects. Here we show that TERS can also be a powerful tool in studying two-dimensional materials. We have achieved a 10^{9} Raman signal enhancement and a 0.5 nm spatial resolution using monolayer silicene on Ag(111) as a prototypical 2D material system. Because of the selective enhancement on Raman modes with vertical vibrational components in TERS, our experiment provides direct evidence of the origination of Raman modes in silicene...
November 10, 2017: Physical Review Letters
J B J Chapman, R E Cohen, A V Kimmel, D M Duffy
We provide a fundamental insight into the microscopic mechanisms of the aging processes. Using large-scale molecular dynamics simulations of the prototypical ferroelectric material PbTiO_{3}, we demonstrate that the experimentally observed aging phenomena can be reproduced from intrinsic interactions of defect dipoles related to dopant-vacancy associates, even in the absence of extrinsic effects. We show that variation of the dopant concentration modifies the material's hysteretic response. We identify a universal method to reduce loss and tune the electromechanical properties of inexpensive ceramics for efficient technologies...
October 27, 2017: Physical Review Letters
J Stein, M Baum, S Holbein, T Finger, T Cronert, C Tölzer, T Fröhlich, S Biesenkamp, K Schmalzl, P Steffens, C H Lee, M Braden
Polarized neutron scattering experiments reveal that type-II multiferroics allow for controlling the spin chirality by external electric fields even in the absence of long-range multiferroic order. In the two prototype compounds TbMnO_{3} and MnWO_{4}, chiral magnetism associated with soft overdamped electromagnons can be observed above the long-range multiferroic transition temperature T_{MF}, and it is possible to control it through an electric field. While MnWO_{4} exhibits chiral correlations only in a tiny temperature interval above T_{MF}, in TbMnO_{3} chiral magnetism can be observed over several kelvin up to the lock-in transition, which is well separated from T_{MF}...
October 27, 2017: Physical Review Letters
Si-Jing Ding, Xiaoguang Li, Fan Nan, Yu-Ting Zhong, Li Zhou, Xudong Xiao, Qu-Quan Wang, Zhenyu Zhang
Recent intense effort has been devoted to exploring different manifestations of resonant excitations of strongly coupled plasmons and excitons, but so far such studies have been limited to situations where the Fano- or Rabi-type spectra are largely symmetric at zero detuning. Using a newly developed full quantum mechanical model, here we reveal the existence of a highly asymmetric spectroscopic regime for both the Rabi splitting and transparency dip. The asymmetric nature is inherently tied to the non-negligible exciton absorbance and is caused by substantial interference-induced energy repartitioning of the resonance peaks...
October 27, 2017: Physical Review Letters
Camille Scalliet, Ludovic Berthier, Francesco Zamponi
Marginally stable solids have peculiar physical properties that were first analyzed in the context of the jamming transition. We theoretically investigate the existence of marginal stability in a prototypical model for structural glass formers, combining analytical calculations in infinite dimensions to computer simulations in three dimensions. While mean-field theory predicts the existence of a Gardner phase transition towards a marginally stable glass phase at low temperatures, simulations show no hint of diverging time scales or length scales, but reveal instead the presence of sparse localized defects...
November 17, 2017: Physical Review Letters
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