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https://www.readbyqxmd.com/read/29451771/structural-transformation-of-wireframe-dna-origami-via-dna-polymerase-assisted-gap-filling
#1
Nayan P Agarwal, Michael Matthies, Bastian Joffroy, Thorsten L Schmidt
The programmability of DNA enables constructing nanostructures with almost any arbitrary shape, which can be decorated with many functional materials. Moreover, dynamic structures can be realized such as molecular motors and walkers. In this work, we have explored the possibility to synthesize the complementary sequences to single-stranded gap regions in the DNA origami scaffold cost effectively by a DNA polymerase rather than by a DNA synthesizer. For this purpose, four different wireframe DNA origami structures were designed to have single-stranded gap regions...
February 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29451741/non-invasive-optical-method-for-real-time-assessment-of-intracorneal-riboflavin-concentration-and-efficacy-of-corneal-cross-linking
#2
Giuseppe Lombardo, Valentina Villari, Norberto Liborio Micali, Nancy Leone, Cristina Labate, Maria Penelope De Santo, Marco Lombardo
Keratoconus is the primary cause of corneal transplantation in young adults worldwide. Riboflavin/UV-A corneal cross-linking may effectively halt the progression of keratoconus if an adequate amount of riboflavin enriches the corneal stroma and is photo-oxidated by UV-A light for generating additional cross-linking bonds between stromal proteins and strengthening the biomechanics of the weakened cornea. Here we reported a UV-A theranostic prototype device for performing corneal cross-linking with the ability to assess corneal intrastromal concentration of riboflavin and to estimate treatment efficacy in real time...
February 16, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29450945/clinical-application-of-3d-technology-for-tooth-autotransplantation-a-case-report
#3
Keunhee Kim, Hee-Seung Choi, Nan-Sim Pang
This report presents two cases of tooth autotransplantation using cone-beam computed tomography (CBCT), the three-dimensional (3D) simulation dental planning software and a computer-aided rapid prototyping (CARP) model. Two hopeless teeth of adult patients were replaced as their third molar teeth. Before deciding the autotransplantation, diagnostic CBCT images were acquired and imported to SimPlant software. The SimPlant dental program was used for surgical simulation prior to autotransplantation, which created 3D images of the available donor teeth and recipient site tooth and superimposed the images to display their morphological similarity...
February 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29450708/metabolism-of-rhizoma-coptidis-in-human-urine-by-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-mass-spectrometry
#4
Qingshan Zhang, Gaowa Wang, Xi Chen, Zhiqiang Han, Xiangmei Chen, Risu Na, Haburi Jin, Ping Li, Renbatu Bu
BACKGROUND AND OBJECTIVES: Rhizoma coptidis extract and its alkaloids were reported to exhibit various pharmacological activities. However, pharmacokinetics investigations indicated that the plasma concentrations of the alkaloids were too low to explain their systemic therapeutic actions. Thus, the metabolic profile of Rhizoma coptidis in humans is yet to be fully investigated and the present study aimed to investigate the metabolic profile of Rhizoma coptidis in human urine after oral administration of Rhizoma coptidis extract...
February 15, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29450695/a-clinical-approach-to-arrhythmias-revisited-in-2018-from-ecg-over-noninvasive-and-invasive-electrophysiology-to-advanced-imaging
#5
REVIEW
L Jordaens
Understanding arrhythmias and their treatment is not always easy. The current straightforward approach with catheter ablation and device therapy is an amazing achievement, but does not make management of underlying or other cardiac disease and pharmacological therapy unnecessary. The goal of this paper is to describe how much of the knowledge of the 1980s and early 1990s can and should still be applied in the modern treatment of patients with arrhythmias. After an introduction, this review will focus on paroxysmal atrial fibrillation and a prototype of 'idiopathic' ventricular arrhythmias, two diseases with a striking similarity, and will discuss the arrhythmogenesis...
February 15, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29449596/heparan-sulfates-facilitate-harmless-amyloidogenic-fibril-formation-interacting-with-elastin-like-peptides
#6
Federica Boraldi, Pasquale Moscarelli, Brigida Bochicchio, Antonietta Pepe, Anna M Salvi, Daniela Quaglino
Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides. HSs bind also to protein moieties accelerating amyloid formation and influencing cytotoxic properties of insoluble fibrils. Interestingly, amyloidogenic polypeptides, despite their supposed pathogenic role, have been recently explored as promising bio-nanomaterials due to their unique and interesting properties. Therefore, we investigated the interactions of HSs, obtained from different sources and exhibiting various degree of sulfation, with synthetic amyloidogenic elastin-like peptides (ELPs), also looking at the effects of these interactions on cell viability and cell behavior using in vitro cultured fibroblasts, as a prototype of mesenchymal cells known to modulate the soft connective tissue environment...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449556/cd1d-dependent-immune-suppression-mediated-by-regulatory-b-cells-through-modulations-of-inkt-cells
#7
K Oleinika, E C Rosser, D E Matei, K Nistala, A Bosma, I Drozdov, C Mauri
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d-lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29449202/a-web-based-psychoeducational-intervention-for-adolescent-depression-design-and-development-of-moodhwb
#8
Rhys Bevan Jones, Anita Thapar, Frances Rice, Harriet Beeching, Rachel Cichosz, Becky Mars, Daniel J Smith, Sally Merry, Paul Stallard, Ian Jones, Ajay K Thapar, Sharon A Simpson
BACKGROUND: Depression is common in adolescence and leads to distress and impairment in individuals, families and carers. Treatment and prevention guidelines highlight the key role of information and evidence-based psychosocial interventions not only for individuals but also for their families and carers. Engaging young people in prevention and early intervention programs is a challenge, and early treatment and prevention of adolescent depression is a major public health concern. There has been growing interest in psychoeducational interventions to provide accurate information about health issues and to enhance and develop self-management skills...
February 15, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29448888/cross-linked-cholecyst-derived-extracellular-matrix-for-abdominal-wall-repair
#9
Jeffrey Chee Yean Chan, Krishna Burugapalli, Yi-Shiang Huang, Jack L Kelly, Abhay Pandit
Abdominal wall repair frequently utilizes either non-degradable or bio-degradable meshes, which are found to stimulate undesirable biological tissue responses or which possess suboptimal degradation rate. In this study, a biologic mesh prototype made from carbodiimide-cross-linked cholecyst-derived extracellular matrix (EDCxCEM) was compared with small intestinal submucosa (Surgisis®), cross-linked bovine pericardium (Peri-Guard®), and polypropylene (Prolene®) meshes in an in vivo rabbit model. The macroscopic appearance and stereological parameters of the meshes were evaluated...
February 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29448376/matrix-product-algorithm-for-stochastic-dynamics-on-networks-applied-to-nonequilibrium-glauber-dynamics
#10
Thomas Barthel, Caterina De Bacco, Silvio Franz
We introduce and apply an efficient method for the precise simulation of stochastic dynamical processes on locally treelike graphs. Networks with cycles are treated in the framework of the cavity method. Such models correspond, for example, to spin-glass systems, Boolean networks, neural networks, or other technological, biological, and social networks. Building upon ideas from quantum many-body theory, our approach is based on a matrix product approximation of the so-called edge messages-conditional probabilities of vertex variable trajectories...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447996/sleep-food-cravings-and-taste
#11
Wen Lv, Graham Findlayson, Robin Dando
OBJECTIVE: Taste is influenced by factors from our environment, psychology, and from our own physiological state. The objective of the study was to determine whether sleep influences our sense of taste or our cravings for food. METHOD: 57 healthy panelists, predominantly of college age, submitted to sleep tracking, and subsequently underwent a series of sensory tests, using basic prototypic tastants as well as real foods. Panelists were also evaluated to quantify food cravings, using both the Leeds Food Preference Questionnaire, and the Control of Eating Questionnaire...
February 12, 2018: Appetite
https://www.readbyqxmd.com/read/29447297/development-of-a-decision-aid-for-cardiopulmonary-resuscitation-and-invasive-mechanical-ventilation-in-the-intensive-care-unit-employing-user-centered-design-and-a-wiki-platform-for-rapid-prototyping
#12
Ariane Plaisance, Holly O Witteman, Annie LeBlanc, Jennifer Kryworuchko, Daren Keith Heyland, Mark H Ebell, Louisa Blair, Diane Tapp, Audrey Dupuis, Carole-Anne Lavoie-Bérard, Carrie Anna McGinn, France Légaré, Patrick Michel Archambault
BACKGROUND: Upon admission to an intensive care unit (ICU), all patients should discuss their goals of care and express their wishes concerning life-sustaining interventions (e.g., cardiopulmonary resuscitation (CPR)). Without such discussions, interventions that prolong life at the cost of decreasing its quality may be used without appropriate guidance from patients. OBJECTIVES: To adapt an existing decision aid about CPR to create a wiki-based decision aid individually adapted to each patient's risk factors; and to document the use of a wiki platform for this purpose...
2018: PloS One
https://www.readbyqxmd.com/read/29447282/addition-of-m6a-to-sv40-late-mrnas-enhances-viral-structural-gene-expression-and-replication
#13
Kevin Tsai, David G Courtney, Bryan R Cullen
Polyomaviruses are a family of small DNA tumor viruses that includes several pathogenic human members, including Merkel cell polyomavirus, BK virus and JC virus. As is characteristic of DNA tumor viruses, gene expression in polyomaviruses is temporally regulated into an early phase, consisting of the viral regulatory proteins, and a late phase, consisting of the viral structural proteins. Previously, the late transcripts expressed by the prototypic polyomavirus simian virus 40 (SV40) were reported to contain several adenosines bearing methyl groups at the N6 position (m6A), although the precise location of these m6A residues, and their phenotypic effects, have not been investigated...
February 15, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29447260/optimal-dose-reduction-algorithm-using-an-attenuation-based-tube-current-modulation-method-for-cone-beam-ct-imaging
#14
Kihong Son, Jieun Chang, Hoyeon Lee, Changhwan Kim, Taewon Lee, Seungryong Cho, Sohyun Park, Jin Sung Kim
To reduce the radiation dose given to patients, a tube current modulation (TCM) method has been widely used in diagnostic CT systems. However, the TCM method has not yet been applied to a kV-CBCT system on a LINAC machine. The purpose of this study is to investigate if a TCM method would be desirable in a kV-CBCT system for image-guided radiation therapy (IGRT) or not. We have developed an attenuation-based TCM method using prior knowledge from planning CT images of patients. The TCM method can provide optimized dose reductions without degrading image quality for kV-CBCT imaging...
2018: PloS One
https://www.readbyqxmd.com/read/29446718/current-trends-and-future-directions-of-fluoroquinolones
#15
Hamada H H Mohammed, Gamal El-Din A A Abuo-Rahma, Samar H Abbas, El-Shimaa M N Abdelhafez
Fluoroquinolones represent an interesting synthetic class of antimicrobial agents with broad spectrum and potent activity. Since the discovery of nalidixic acid, the prototype of quinolones, several structural modifications to the quinolone nucleus have been carried out for improvement of potency, spectrum of activity, and to understand their structure activity relationship (SAR). The C-7 substituent was reported to have a major impact on the activity. Accordingly, Substitution at C-7 or its N-4-piperazinyl moiety was found to affect potency, bioavailability, and physicochemical properties...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29446633/a-molecular-dynamics-study-of-the-solution-structure-clustering-and-diffusion-of-four-aqueous-alkanolamines
#16
Sergey M Melnikov, Matthias Stein
CO 2 sequestration from anthropogenic resources is a challenge to the design of environmental processes at large scale. Chemical reversible absorption by amine based solvents is considered as the most promising method of CO 2 absorption. Molecular simulation techniques prove to be very useful tools to investigate CO 2 binding by aqueous amines for further technological improvements. In the present work we have performed detailed molecular dynamics study of aqueous solution of three prototype amines: ethanolamine (MEA) as a standard, 3-aminopropanol (MPA), 2-methylaminoethanol (MMEA) and 4-diethylamino-2-butanol (DEAB) as potential novel CO 2 absorptive solvents...
February 15, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29446620/polydopamine-coated-main-chain-liquid-crystal-elastomer-as-optically-driven-artificial-muscle
#17
Hongmiao Tian, Zhijian Wang, Yilong Chen, Jinyou Shao, Tong Gao, Shengqiang Cai
Optically-driven active materials have received much attention because their deformation and motion can be controlled remotely, instantly and precisely in a contactless way. In this article, we investigated an optically-actuated elastomer with rapid response: polydopamine (PDA)-coated liquid crystal elastomer (LCE). Due to the photothermal effect of PDA coating and thermal responsiveness of LCE, the elastomer film contracted significantly with near infrared (NIR) irradiation. With a fixed strain, light-induced actuating stress in the film could be as large as 1...
February 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29446527/nonbinary-quantification-technique-accounting-for-myocardial-infarct-heterogeneity-feasibility-of-applying-percent-infarct-mapping-in-patients
#18
Domenico Mastrodicasa, Gabriel A Elgavish, U Joseph Schoepf, Pal Suranyi, Marly van Assen, Moritz H Albrecht, Carlo N De Cecco, Rob J van der Geest, Rayphael Hardy, Cesare Mantini, L Parkwood Griffith, Balazs Ruzsics, Akos Varga-Szemes
BACKGROUND: Binary threshold-based quantification techniques ignore myocardial infarct (MI) heterogeneity, yielding substantial misquantification of MI. PURPOSE: To assess the technical feasibility of MI quantification using percent infarct mapping (PIM), a prototype nonbinary algorithm, in patients with suspected MI. STUDY TYPE: Prospective cohort POPULATION: Patients (n = 171) with suspected MI referred for cardiac MRI. FIELD STRENGTH/SEQUENCE: Inversion recovery balanced steady-state free-precession for late gadolinium enhancement (LGE) and modified Look-Locker inversion recovery (MOLLI) T 1 -mapping on a 1...
February 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29446083/development-and-clinical-characterization-of-a-novel-2041-liquid-filled-ionization-chambers-array-for-high-resolution-verification-of-radiotherapy-treatments
#19
L Brualla-González, A Vázquez-Luque, M Zapata, D M González-Castaño, V Luna-Vega, J Guiu-Souto, J Prieto-Pena, T García, D Granero, A Vicedo, J Rosellò, M Pombar, F Gómez, J Pardo-Montero
PURPOSE: To present a novel 2041 liquid-filled ionization chamber array for high-resolution verification of radiotherapy treatments. MATERIALS AND METHODS: The prototype has 2041 ionization chambers of 2.5×2.5 mm 2 area filled with isooctane. The detection elements are arranged in a central square grid of 43×43, totally covering an area of 107.5×107.5 mm 2 . The central inline and crossline are extended to 227 mm and the diagonals to 321 mm in order to be able to perform profile measurements of large fields...
February 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29446082/development-of-a-dual-energy-computed-tomography-quality-control-program-characterization-of-scanner-response-and-definition-of-relevant-parameters-for-a-fast-kvp-switching-dect-system
#20
Jessica L Nute, Megan C Jacobsen, Wolfgang Stefan, Wei Wei, Dianna D Cody
PURPOSE: A prototype QC phantom system and analysis process were developed to characterize the spectral capabilities of a fast kV-switching dual-energy computed tomography (DECT) scanner. This work addresses the current lack of quantitative oversight for this technology, with the goal of identifying relevant scan parameters and test metrics instrumental to the development of a dual-energy quality control (DEQC). METHODS: A prototype elliptical phantom (effective diameter: 35 cm) was designed with multiple material inserts for DECT imaging...
February 15, 2018: Medical Physics
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