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https://www.readbyqxmd.com/read/28231320/improved-image-quality-and-diagnostic-potential-using-ultra-high-resolution-computed-tomography-of-the-lung-with-small-scan-fov-a-prospective-study
#1
Huiyuan Zhu, Lian Zhang, Yali Wang, Preeti Hamal, Xiaofang You, Haixia Mao, Fei Li, Xiwen Sun
The aim of this study was to assess whether CT imaging using an ultra-high-resolution CT (UHRCT) scan with a small scan field of view (FOV) provides higher image quality and helps to reduce the follow-up period compared with a conventional high-resolution CT (CHRCT) scan. We identified patients with at least one pulmonary nodule at our hospital from July 2015 to November 2015. CHRCT and UHRCT scans were conducted in all enrolled patients. Three experienced radiologists evaluated the image quality using a 5-point score and made diagnoses...
2017: PloS One
https://www.readbyqxmd.com/read/28231269/a-mouse-model-of-paralytic-myelitis-caused-by-enterovirus-d68
#2
Alison M Hixon, Guixia Yu, J Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y Chiu, Kenneth L Tyler
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA detected by RT-PCR in their respiratory secretions, although EV-D68 was only detected in cerebrospinal fluid (CSF) from one 2014 AFM patient. Given previously described molecular and epidemiologic associations between EV-D68 and AFM, we sought to develop an animal model by screening seven EV-D68 strains for the ability to induce neurological disease in neonatal mice...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28230793/dynamic-fluid-in-a-porous-transducer-based-angular-accelerometer
#3
Siyuan Cheng, Mengyin Fu, Meiling Wang, Li Ming, Huijin Fu, Tonglei Wang
This paper presents a theoretical model of the dynamics of liquid flow in an angular accelerometer comprising a porous transducer in a circular tube of liquid. Wave speed and dynamic permeability of the transducer are considered to describe the relation between angular acceleration and the differential pressure on the transducer. The permeability and streaming potential coupling coefficient of the transducer are determined in the experiments, and special prototypes are utilized to validate the theoretical model in both the frequency and time domains...
February 21, 2017: Sensors
https://www.readbyqxmd.com/read/28230393/going-off-script-effects-of-awe-on-memory-for-script-typical-and-irrelevant-narrative-detail
#4
Alexander F Danvers, Michelle N Shiota
People often filter their experience of new events through knowledge they already have; for example, encoding new events by relying on prototypical event "scripts" at the expense of actual details. Previous research suggests that positive affect often increases this tendency. Three studies assessed whether awe-an emotion elicited by perceived vastness, and thought to promote cognitive accommodation-has the opposite effect, reducing rather than increasing reliance on event scripts. True/false questions on details of a short story about a romantic dinner were used to determine whether awe (a) reduces the tendency to impute script-consistent but false details into memory, and/or (b) promotes memory of unexpected details...
February 23, 2017: Emotion
https://www.readbyqxmd.com/read/28230387/a-computer-adaptive-testing-version-of-the-addiction-severity-index-multimedia-version-asi-mv-the-addiction-severity-cat
#5
Stephen F Butler, Ryan A Black, Stacey A McCaffrey, Jessica Ainscough, Ann M Doucette
The purpose of this study was to develop and validate a computer adaptive testing (CAT) version of the Addiction Severity Index-Multimedia Version (ASI-MV), the Addiction Severity CAT. This goal was accomplished in 4 steps. First, new candidate items for Addiction Severity CAT domains were evaluated after brainstorming sessions with experts in substance abuse treatment. Next, this new item bank was psychometrically evaluated on a large nonclinical (n = 4,419) and substance abuse treatment (n = 845) sample. Based on these results, final items were selected and calibrated for the creation of the Addiction Severity CAT algorithms...
February 23, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28230359/efficient-liver-targeting-by-polyvalent-display-of-a-compact-ligand-for-the-asialoglycoprotein-receptor
#6
Carlos A Sanhueza, Michael M Baksh, Benjamin Thuma, Marc D Roy, Sanjay Dutta, Cathy Préville, Boris A Chrunyk, Kevin Beaumont, Robert Dullea, Mark Ammirati, Shenping Liu, David Gebhard, James E Finley, Christopher T Salatto, Amanda King-Ahmad, Ingrid Stock, Karen Atkinson, Benjamin Reidich, Wen Lin, Rajesh Kumar, Meihua Tu, Elnaz Menhaji-Klotz, David A Price, Spiros Liras, M G Finn, Vincent Mascitti
A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structures of ligand-bound ASGPR. This analogue was used to make potent di- and trivalent binders of ASGPR. Extensive characterization of the function of these compounds showed rapid ASGPR-dependent cellular uptake in vitro and high levels of liver/plasma selectivity in vivo...
February 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28230346/high-strength-stereolithographic-3d-printed-nanocomposites-graphene-oxide-metastability
#7
Jill Z Manapat, Joey Dacula Mangadlao, Brylee David Buada Tiu, Grace C Tritchler, Rigoberto C Advincula
The weak thermomechanical properties of commercial 3D printing plastics have limited the technology's application mainly to rapid prototyping. In this report, we demonstrate a simple approach that takes advantage of the metastable, temperature-dependent structure of graphene oxide (GO) to enhance the mechanical properties of conventional 3D-printed resins produced by stereolithography (SLA). A commercially available SLA resin was reinforced with minimal amounts of GO nanofillers and thermally annealed at 50 °C and 100 °C for 12 hours...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229497/drinkers-identification-with-varying-alcohol-consumption-prototypes
#8
Simone Pettigrew, Michelle I Jongenelis, Iain S Pratt, Terry Slevin, Tanya Chikritzhs
INTRODUCTION AND AIMS: Efforts to reduce excessive alcohol consumption need to take into account drinkers' perceptions of their risk of alcohol-related harm. The aim of the present study was to profile adult Australian drinkers according to their self-identification with various drinker prototypes to determine the extent to which these prototypes are associated with perceived and actual risk of alcohol-related harm. DESIGN AND METHODS: A large web panel provider disseminated an online survey to a national sample of 2168 drinkers aged 18+ years who consumed alcohol at least twice per month...
February 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28229424/three-dimensional-printed-scaffolds-with-multipotent-mesenchymal-stromal-cells-for-rabbit-mandibular-reconstruction-and-engineering
#9
Dongdong Fang, Michael Roskies, Mohamed-Nur Abdallah, Mohammed Bakkar, Jack Jordan, Li-Chieh Lin, Faleh Tamimi, Simon D Tran
Multipotent mesenchymal stromal cells (MSC) derived from both the bone marrow and adipose tissue possess the ability to differentiate into multiple cell lineages, regulate the immune function by secreting numerous bioactive paracrine factors, and hold great potential in cell therapy and tissue engineering. When combined with three-dimensional (3D) scaffolds, MSC can be used for bone defect reconstruction and engineering. This protocol describes the isolation of bone marrow mesenchymal stromal cells (BMMSC) and adipose-tissue derived stem cells (ADSC) from rabbits for subsequent seeding on tissue-engineered 3D-printed scaffolds and transplantation into a rabbit-model with the goal of repairing large osseous mandibular defects (one quarter of the lower jaw is removed surgically)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229352/linshom-thermodynamic-sensor-is-a-reliable-alternative-to-capnography-for-monitoring-respiratory-rate
#10
David Preiss, Benjamin A Drew, James Gosnell, Bhavani S Kodali, James H Philip, Richard D Urman
Monitoring ventilation accurately is a technically challenging, yet indispensable aspect of patient care in the intra- and post-procedural settings. A new prototypical device known as the Linshom Respiratory Monitoring Device (LRMD) has been recently designed to non-invasively, inexpensively, and portably measure respiratory rate. The purpose of this study was to measure the accuracy and variability of LRMD measurements of respiratory rate relative to the measurement of capnography. In this prospective study, participants were enrolled and individually fitted with a face mask monitored by the LRMD and capnography...
February 22, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28227952/smartstuff-a-case-study-of-a-smart-water-bottle
#11
Emil Jovanov, Vindhya R Nallathimmareddygari, Jonathan E Pryor, Emil Jovanov, Vindhya R Nallathimmareddygari, Jonathan E Pryor, Vindhya R Nallathimmareddygari, Emil Jovanov, Jonathan E Pryor
The rapid growth of Internet of Things (IoT) and miniature wearable biosensors have generated new opportunities for personalized eHealth and mHealth services. Smart objects equipped with physiological sensors can provide robust monitoring of activities of daily living and context for wearable physiological sensors. We present a case study of an intelligent water bottle that can precisely measure the amount of liquid in the bottle, monitor activity using inertial sensors, and physiological parameters using a touch and photoplethysmographic sensor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227879/wearable-diagnostic-system-for-age-related-macular-degeneration
#12
N Mohaghegh, E Ghafar Zadeh, S Magierowski, N Mohaghegh, E Ghafar Zadeh, S Magierowski, N Mohaghegh, E Ghafar Zadeh, S Magierowski
This paper presents a novel head-mounted point-of-care diagnostic system for detection and continuous monitoring of Age-related Macular Degeneration (AMD). This wearable embedded open-source platform enables accurate monitoring of AMD by taking advantage of multiple standard graphical interface techniques such as Amsler Grid, Threshold Amsler Grid, Macular Computerized Psychophysical Test and Preferential Hyperacuity Perimeter (PHP). Here, we describe the proposed multi-Grid or so-called NGRID software and elaborate on the hardware prototype...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227838/alleviating-freezing-of-gait-using-phase-dependent-tactile-biofeedback
#13
Will Harrington, Andrew Greenberg, Edward King, James McNames, Lars Holmstrom, Fay B Horak, Martina Mancini, Will Harrington, Andrew Greenberg, Edward King, James McNames, Lars Holmstrom, Fay B Horak, Martina Mancini, Edward King, Lars Holmstrom, Martina Mancini, James McNames, Fay B Horak, Will Harrington, Andrew Greenberg
In this feasibility study, we present a novel, wearable prototype of tactile biofeedback to alleviate gait disturbances, such as freezing of gait in Parkinson's disease. We designed and tested a phase-dependent tactile biofeedback system that can be easily worn on the feet, with a simple switch to turn it on or off. Preliminary validation was performed in 8 subjects with Parkinson's disease who show freezing during a turning in place test. A metronome, control condition was used to compare effectiveness in alleviating freezing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227730/prototyping-context-aware-nursing-support-mobile-system
#14
Misa Esashi, Tomohiro Nakano, Nao Onose, Kikue Sato, Tomoko Hikita, Reiko Hoya, Kazuya Okamoto, Naoki Ohboshi, Tomohiro Kuroda, Misa Esashi, Tomohiro Nakano, Nao Onose, Kikue Sato, Tomoko Hikita, Reiko Hoya, Kazuya Okamoto, Naoki Ohboshi, Tomohiro Kuroda, Kikue Sato, Tomohiro Nakano, Tomoko Hikita, Naoki Ohboshi, Misa Esashi, Nao Onose, Tomohiro Kuroda, Kazuya Okamoto, Reiko Hoya
A context aware nursing support system to push right information to the right person at the right moment is the key to increase clinical safety under a computerized hospital. We prototyped a system which obtains context from positions of nurses and list of expected clinical procedures. A WoZ test showed that the proposed approach has potential to decrease incidents caused by information delivery error.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227717/audis-wear-a-smartwatch-based-assistive-device-for-ubiquitous-awareness-of-environmental-sounds
#15
Matthias Mielke, Rainer Bruck, Matthias Mielke, Rainer Bruck, Rainer Bruck, Matthias Mielke
A multitude of assistive devices is available for deaf people (i.e. deaf, deafened, and hard of hearing). Besides hearing and communication aids, devices to access environmental sounds are available commercially. But the devices have two major drawbacks: 1. they are targeted at indoor environments (e.g. home or work), and 2. only specific events are supported (e.g. the doorbell or telephone). Recent research shows that important sounds can occur in all contexts and that the interests in sounds are diverse. These drawbacks can be tackled by using modern information and communication technology that enables the development of new and improved assistive devices...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227681/wearable-impedance-monitoring-system-for-dialysis-patients
#16
S Bonnet, A Bourgerette, S Gharbi, C Rubeck, W Arkouche, B Massot, E McAdams, A Montalibet, P Jallon, S Bonnet, A Bourgerette, S Gharbi, C Rubeck, W Arkouche, B Massot, E McAdams, A Montalibet, P Jallon, A Bourgerette, B Massot, P Jallon, C Rubeck, S Gharbi, A Montalibet, W Arkouche, S Bonnet, E McAdams
This paper describes the development and the validation of a prototype wearable miniaturized impedance monitoring system for remote monitoring in home-based dialysis patients. This device is intended to assess the hydration status of dialysis patients using calf impedance measurements. The system is based on the low-power AD8302 component. The impedance calibration procedure is described together with the Cole parameter estimation and the hydric volume estimation. Results are given on a test cell to validate the design and on preliminary calf measurements showing Cole parameter variations during hemodialysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227674/the-impact-of-different-leaf-limited-accelerations-on-leaf-positional-error-of-a-self-developed-mlc-prototype
#17
Xiang Zhang, Peiqing Ye, Hui Zhang, Xiang Zhang, Peiqing Ye, Hui Zhang, Peiqing Ye, Hui Zhang, Xiang Zhang
Multi-leaf collimator (MLC) provides an available approach to achieve sophisticated radiotherapy techniques and plays an important role in advanced high quality radiation therapy. Delivery accuracy of radiation therapy mainly depends on the leaf sequence generated by treatment plans and dynamic performance of MLCs. Previous studies have explored the influence of various leaf limited velocities and dose rates on the leaf-positional error. However, there is a lack of research on the influence of different leaf limited accelerations on the delivery accuracy or leaf-positional error...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227671/imquant-an-image-based-fluorescence-reader-for-quantitative-lateral-flow-immunoassays
#18
Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Jayaraj Joseph, Kaushik Basak Chowdhury
Fluorescence immunoassays (FIA) have strong potential in enabling rapid quantitative immunological testing at point of care. Existing state of the art instruments employ laser scanning of FIA test kits, which require the use of electromechanical systems, making the instrument bulky, heavy and less reliable in the long term. There is a growing need for an extremely compact and reliable, motion-free, automated reader for accurate quantification of immunoassays. Here, we present ImQuant, an image based FIA reader with integrated monochromatic excitation source, optical filtering and real time image capture, assisted with an intuitive graphical user interface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227670/diffuse-reflectance-spectroscopy-can-differentiate-high-grade-and-low-grade-prostatic-carcinoma
#19
Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa, Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa, John W Daily, Adrie Van Bokhoven, E David Crawford, J David Port, Priya N Werahera, M Scott Lucia, Holly T Sullivan, Paul D Maroni, Edward A Jasion, Francisco G La Rosa, Fernando J Kim
Prostate tumors are graded by the revised Gleason Score (GS) which is the sum of the two predominant Gleason grades present ranging from 6-10. GS 6 cancer exclusively with Gleason grade 3 is designated as low grade (LG) and correlates with better clinical prognosis for patients. GS >7 cancer with at least one of the Gleason grades 4 and 5 is designated as HG indicate worse prognosis for patients. Current transrectal ultrasound guided prostate biopsies often fail to correctly diagnose HG prostate cancer due to sampling errors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227665/hardware-design-for-a-cable-free-fully-insertable-wireless-laparoscopic-robotic-camera
#20
Ning Li, Gregory J Mancini, Jindong Tan, Ning Li, Gregory J Mancini, Jindong Tan, Gregory J Mancini, Ning Li, Jindong Tan
The field of insertable laparoscopic robotic camera is gaining increasing attentions from researchers, surgeons, and also patients. Although many insertable laparoscope prototypes have been introduced, few of them get rid of the encumbrance tethering cable. In this paper, we proposed a hardware architecture for a magnetic actuated robotic surgical (MARS) camera, which facilitates a cable-free fully insertable laparoscopic surgical robotic camera with adequate in-vivo mobility. Modular design and preliminary test of on-board functional payloads have shown feasibility of a cable-free insertable wireless laparoscopic surgical camera based on off-the-shelf electronics and industrial wireless standards operating in ISM frequency bands at 2...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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