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https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#1
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
December 2, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27913653/dimensional-evaluation-of-patient-specific-3d-printing-using-calcium-phosphate-cement-for-craniofacial-bone-reconstruction
#2
Liciane Sabadin Bertol, Rodrigo Schabbach, Luís Alberto Loureiro Dos Santos
The 3D printing process is highlighted nowadays as a possibility to generate individual parts with complex geometries. Moreover, the development of 3D printing hardware, software and parameters permits the manufacture of parts that can be not only used as prototypes, but are also made from materials that are suitable for implantation. In this way, this study investigates the process involved in the production of patient-specific craniofacial implants using calcium phosphate cement, and its dimensional accuracy...
December 1, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27911897/heterologous-protection-against-asian-zika-virus-challenge-in-rhesus-macaques
#3
Matthew T Aliota, Dawn M Dudley, Christina M Newman, Emma L Mohr, Dane D Gellerup, Meghan E Breitbach, Connor R Buechler, Mustafa N Rasheed, Mariel S Mohns, Andrea M Weiler, Gabrielle L Barry, Kim L Weisgrau, Josh A Eudailey, Eva G Rakasz, Logan J Vosler, Jennifer Post, Saverio Capuano, Thaddeus G Golos, Sallie R Permar, Jorge E Osorio, Thomas C Friedrich, Shelby L O'Connor, David H O'Connor
BACKGROUND: Zika virus (ZIKV; Flaviviridae, Flavivirus) was declared a public health emergency of international concern by the World Health Organization (WHO) in February 2016, because of the evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome in adults and congenital birth defects including microcephaly in the developing fetus. Because development of a ZIKV vaccine is a top research priority and because the genetic and antigenic variability of many RNA viruses limits the effectiveness of vaccines, assessing whether immunity elicited against one ZIKV strain is sufficient to confer broad protection against all ZIKV strains is critical...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27911796/egr2-and-egr3-in-regulatory-t-cells-cooperatively-control-systemic-autoimmunity-through-ltbp3-mediated-tgf-%C3%AE-3-production
#4
Kaoru Morita, Tomohisa Okamura, Mariko Inoue, Toshihiko Komai, Shuzo Teruya, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Keishi Fujio
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by multiorgan inflammation induced by autoantibodies. Early growth response gene 2 (Egr2), a transcription factor essential for T-cell anergy induction, controls systemic autoimmunity in mice and humans. We have previously identified a subpopulation of CD4(+) regulatory T cells, CD4(+)CD25(-)LAG3(+) cells, that characteristically express both Egr2 and LAG3 and control mice model of lupus via TGF-β3 production. However, due to the mild phenotype of lymphocyte-specific Egr2-deficient mice, the presence of an additional regulator has been speculated...
November 30, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911774/optically-transparent-semiconducting-polymer-nanonetwork-for-flexible-and-transparent-electronics
#5
Kilho Yu, Byoungwook Park, Geunjin Kim, Chang-Hyun Kim, Sungjun Park, Jehan Kim, Suhyun Jung, Soyeong Jeong, Sooncheol Kwon, Hongkyu Kang, Junghwan Kim, Myung-Han Yoon, Kwanghee Lee
Simultaneously achieving high optical transparency and excellent charge mobility in semiconducting polymers has presented a challenge for the application of these materials in future "flexible" and "transparent" electronics (FTEs). Here, by blending only a small amount (∼15 wt %) of a diketopyrrolopyrrole-based semiconducting polymer (DPP2T) into an inert polystyrene (PS) matrix, we introduce a polymer blend system that demonstrates both high field-effect transistor (FET) mobility and excellent optical transparency that approaches 100%...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911397/nanostructured-ag-zeolite-composites-as-luminescence-based-humidity-sensors
#6
Eduardo Coutino-Gonzalez, Wouter Baekelant, Bjorn Dieu, Maarten B J Roeffaers, Johan Hofkens
Small silver clusters confined inside zeolite matrices have recently emerged as a novel type of highly luminescent materials. Their emission has high external quantum efficiencies (EQE) and spans the whole visible spectrum. It has been recently reported that the UV excited luminescence of partially Li-exchanged sodium Linde type A zeolites [LTA(Na)] containing luminescent silver clusters can be controlled by adjusting the water content of the zeolite. These samples showed a dynamic change in their emission color from blue to green and yellow upon an increase of the hydration level of the zeolite, showing the great potential that these materials can have as luminescence-based humidity sensors at the macro and micro scale...
November 15, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910875/an-integrated-modelling-framework-from-cells-to-organism-based-on-a-cohort-of-digital-embryos
#7
Paul Villoutreix, Julien Delile, Barbara Rizzi, Louise Duloquin, Thierry Savy, Paul Bourgine, René Doursat, Nadine Peyriéras
We conducted a quantitative comparison of developing sea urchin embryos based on the analysis of five digital specimens obtained by automatic processing of in toto 3D+ time image data. These measurements served the reconstruction of a prototypical cell lineage tree able to predict the spatiotemporal cellular organisation of a normal sea urchin blastula. The reconstruction was achieved by designing and tuning a multi-level probabilistic model that reproduced embryo-level dynamics from a small number of statistical parameters characterising cell proliferation, cell surface area and cell volume evolution along the cell lineage...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910847/efficiency-limits-for-photoelectrochemical-water-splitting
#8
Katherine T Fountaine, Hans Joachim Lewerenz, Harry A Atwater
Theoretical limiting efficiencies have a critical role in determining technological viability and expectations for device prototypes, as evidenced by the photovoltaics community's focus on detailed balance. However, due to their multicomponent nature, photoelectrochemical devices do not have an equivalent analogue to detailed balance, and reported theoretical efficiency limits vary depending on the assumptions made. Here we introduce a unified framework for photoelectrochemical device performance through which all previous limiting efficiencies can be understood and contextualized...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27910729/identification-of-cytochrome-p450s-involved-in-the-metabolism-of-6-benzyl-1-benzyloxymethyl-5-iodouracil-w-1-using-human-recombinant-enzymes-and-rat-liver-microsomes-in-vitro
#9
Ying-Yuan Lu, Hai-Xu Cheng, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Ya-Qing Lou, Jun Li, Chuang Lu, Guo-Liang Zhang
1. The aim of this study was to identify the hepatic metabolic enzymes, which involved in the biotransformation of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor (NNRTIs) in rat and human in vitro. 2. The parent drug of W-1 was incubated with RLMs or recombinant CYPs (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP3A5, respectively) in the presence or absence of NADPH regenerating system. The metabolites of W-1 were analyzed with liquid chromatography-ion trap-time of flight-mass spectrometry (LC-IT-TOF-MS)...
December 2, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27910678/first-results-from-the-thomson-scattering-diagnostic-on-proto-mpex
#10
T M Biewer, S Meitner, J Rapp, H Ray, G Shaw
A Thomson scattering (TS) diagnostic has been successfully implemented on the prototype Material Plasma Exposure eXperiment (Proto-MPEX) at Oak Ridge National Laboratory. The diagnostic collects the light scattered by plasma electrons and spectroscopically resolves the Doppler shift imparted to the light by the velocity of the electrons. The spread in velocities is proportional to the electron temperature, while the total number of photons is proportional to the electron density. TS is a technique used on many devices to measure the electron temperature (Te) and electron density (ne) of the plasma...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910639/performance-of-the-prototype-labr3-spectrometer-developed-for-the-jet-gamma-ray-camera-upgrade
#11
D Rigamonti, A Muraro, M Nocente, V Perseo, G Boltruczyk, A Fernandes, J Figueiredo, L Giacomelli, G Gorini, M Gosk, V Kiptily, S Korolczuk, S Mianowski, A Murari, R C Pereira, E P Cippo, I Zychor, M Tardocchi
In this work, we describe the solution developed by the gamma ray camera upgrade enhancement project to improve the spectroscopic properties of the existing JET γ-ray camera. Aim of the project is to enable gamma-ray spectroscopy in JET deuterium-tritium plasmas. A dedicated pilot spectrometer based on a LaBr3 crystal coupled to a silicon photo-multiplier has been developed. A proper pole zero cancellation network able to shorten the output signal to a length of 120 ns has been implemented allowing for spectroscopy at MHz count rates...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910628/final-design-of-thermal-diagnostic-system-in-spider-ion-source
#12
M Brombin, M Dalla Palma, R Pasqualotto, N Pomaro
The prototype radio frequency source of the ITER heating neutral beams will be first tested in SPIDER test facility to optimize H(-) production, cesium dynamics, and overall plasma characteristics. Several diagnostics will allow to fully characterise the beam in terms of uniformity and divergence and the source, besides supporting a safe and controlled operation. In particular, thermal measurements will be used for beam monitoring and system protection. SPIDER will be instrumented with mineral insulated cable thermocouples, both on the grids, on other components of the beam source, and on the rear side of the beam dump water cooled elements...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910604/response-function-of-single-crystal-synthetic-diamond-detectors-to-1-4-mev-neutrons-for-spectroscopy-of-d-plasmas
#13
M Rebai, L Giacomelli, A Milocco, M Nocente, D Rigamonti, M Tardocchi, F Camera, C Cazzaniga, Z J Chen, T F Du, T S Fan, A Giaz, Z M Hu, T Marchi, X Y Peng, G Gorini
A Single-crystal Diamond (SD) detector prototype was installed at Joint European Torus (JET) in 2013 and the achieved results have shown its spectroscopic capability of measuring 2.5 MeV neutrons from deuterium plasmas. This paper presents measurements of the SD response function to monoenergetic neutrons, which is a key point for the development of a neutron spectrometer based on SDs and compares them with Monte Carlo simulations. The analysis procedure allows for a good reconstruction of the experimental results...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910565/first-neutron-spectroscopy-measurements-with-a-pixelated-diamond-detector-at-jet
#14
A Muraro, L Giacomelli, M Nocente, M Rebai, D Rigamonti, F Belli, P Calvani, J Figueiredo, M Girolami, G Gorini, G Grosso, A Murari, S Popovichev, D M Trucchi, M Tardocchi
A prototype Single crystal Diamond Detector (SDD) was installed at the Joint European Torus (JET) in 2013 along an oblique line of sight and demonstrated the possibility to carry out neutron spectroscopy measurements with good energy resolution and detector stability in discharges heated by neutral beam injection and radio-frequency waves. Starting from these positive results, within the Vertical Neutron Spectrometer project of the Joint European Torus, we have developed a pixelated instrument consisting of a matrix of 12 independent SDDs, called the Diamond Vertical Neutron Spectrometer (DVNS), which boosts the detection efficiency of a single SDD by an order of magnitude...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910542/design-and-first-plasma-measurements-of-the-iter-ece-prototype-radiometer
#15
M E Austin, M W Brookman, W L Rowan, S Danani, E W Bryerton, P Dougherty
On ITER, second harmonic optically thick electron cyclotron emission (ECE) in the range of 220-340 GHz will supply the electron temperature (Te). To investigate the requirements and capabilities prescribed for the ITER system, a prototype radiometer covering this frequency range has been developed by Virginia Diodes, Inc. The first plasma measurements with this instrument have been carried out on the DIII-D tokamak, with lab bench tests and measurements of third through fifth harmonic ECE from high Te plasmas...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910535/new-compact-and-efficient-local-oscillator-optic-system-for-the-kstar-electron-cyclotron-emission-imaging-system
#16
Y B Nam, D J Lee, J Lee, C Kim, G S Yun, W Lee, H K Park
Electron cyclotron emission imaging (ECEI) diagnostic on Korean Superconducting Tokamak Advanced Research utilizes quasi-optical heterodyne-detection method to measure 2D (vertical and radial) Te fluctuations from two toroidally separated poloidal cross section of the plasma. A cylindrical lens local oscillator (LO) optics with optical path length (OPL) 2-2.5 m has been used in the current ECEI system to couple the LO source to the 24 vertically aligned array of ECE detectors. For efficient and compact LO optics employing the Powell lens is proposed so that the OPL of the LO source is significantly reduced from ∼2...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910529/development-of-a-beam-ion-velocity-detector-for-the-heavy-ion-beam-probe
#17
P J Fimognari, T P Crowley, D R Demers
In an axisymmetric plasma, the conservation of canonical angular momentum constrains heavy ion beam probe (HIBP) trajectories such that measurement of the toroidal velocity component of secondary ions provides a localized determination of the poloidal flux at the volume where they originated. We have developed a prototype detector which is designed to determine the beam angle in one dimension through the detection of ion current landing on two parallel planes of detecting elements. A set of apertures creates a pattern of ion current on wires in the first plane and solid metal plates behind them; the relative amounts detected by the wires and plates determine the angle which beam ions enter the detector, which is used to infer the toroidal velocity component...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910463/design-and-experiments-of-a-linear-piezoelectric-motor-driven-by-a-single-mode
#18
Zhen Liu, Zhiyuan Yao, Xiang Li, Qianwei Fu
In this contribution, we propose a novel linear piezoelectric motor with a compact stator that is driven by a single mode. The linear piezoelectric motor can realize bidirectional motion by changing the vibration modes of the stator. Finite element analysis is performed to determine the required vibration mode of the stator and obtain the optimal stator structure and dimensions. Furthermore, the trajectories of the driving foot are analyzed with and without consideration of the mechanical contact with the slider...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910428/design-of-a-digital-holography-system-for-pfc-erosion-measurements-on-proto-mpex
#19
C E Tommy Thomas, T M Biewer, L R Baylor, S K Combs, S J Meitner, J Rapp, D L Hillis, E M Granstedt, R Majeski, R Kaita
A project has been started at ORNL to develop a dual-wavelength digital holography system for plasma facing component erosion measurements on prototype material plasma exposure experiment. Such a system will allow in situ real-time measurements of component erosion. Initially the system will be developed with one laser, and first experimental laboratory measurements will be made with the single laser system. In the second year of development, a second CO2 laser will be added and measurements with the dual wavelength system will begin...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910411/design-and-characterization-of-a-prototype-divertor-viewing-infrared-video-bolometer-for-nstx-u
#20
G G van Eden, M L Reinke, B J Peterson, T K Gray, L F Delgado-Aparicio, M A Jaworski, J Lore, K Mukai, R Sano, S N Pandya, T W Morgan
The InfraRed Video Bolometer (IRVB) is a powerful tool to measure radiated power in magnetically confined plasmas due to its ability to obtain 2D images of plasma emission using a technique that is compatible with the fusion nuclear environment. A prototype IRVB has been developed and installed on NSTX-U to view the lower divertor. The IRVB is a pinhole camera which images radiation from the plasma onto a 2.5 μm thick, 9 × 7 cm(2) Pt foil and monitors the resulting spatio-temporal temperature evolution using an IR camera...
November 2016: Review of Scientific Instruments
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