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JOURNAL ARTICLE
Ingo Borggraefe, Jan Simon Schaefer, Mirjam Klaiber, Edward Dabrowski, Corinne Ammann-Reiffer, Beat Knecht, Steffen Berweck, Florian Heinen, Andreas Meyer-Heim
OBJECTIVE: Task-specific body-weight-supported treadmill therapy improves walking performance in children with central gait impairment. The aim of the study was to investigate the effect of robotic-assisted treadmill therapy on standing and walking performance in children and adolescents with cerebral palsy and to determine parameters influencing outcome. METHODS: 20 Patients (mean age 11.0 ± 5.1, 10 males and 10 females) with cerebral palsy underwent 12 sessions of robotic-assisted treadmill therapy using the driven gait orthosis Lokomat...
November 2010: European Journal of Paediatric Neurology: EJPN
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REVIEW
Florian Heinen, Kaat Desloovere, A Sebastian Schroeder, Steffen Berweck, Ingo Borggraefe, Anya van Campenhout, Guro L Andersen, Resa Aydin, Jules G Becher, Günther Bernert, Ignacio Martinez Caballero, Lucinda Carr, Emmanuelle Chaleat Valayer, Maria Teresa Desiato, Charlie Fairhurst, Paul Filipetti, Ralph-Ingo Hassink, Ulf Hustedt, Marek Jozwiak, Serdar Ibrahim Kocer, Elisabeth Kolanowski, Ingeborg Krägeloh-Mann, Sehim Kutlay, Helena Mäenpää, Volker Mall, Paul McArthur, Edith Morel, Antigone Papavassiliou, Ignacio Pascual-Pascual, Søren Anker Pedersen, Frank S Plasschaert, Irene van der Ploeg, Olivier Remy-Neris, Anne Renders, Guiseppe Di Rosa, Maja Steinlin, Kristina Tedroff, Joan Vidal Valls, Elke Viehweger, Guy Molenaers
An interdisciplinary European group of clinical experts in the field of movement disorders and experienced Botulinum toxin users has updated the consensus for the use of Botulinum toxin in the treatment of children with cerebral palsy (CP). A problem-orientated approach was used focussing on both published and practice-based evidence. In part I of the consensus the authors have tabulated the supporting evidence to produce a concise but comprehensive information base, pooling data and experience from 36 institutions in 9 European countries which involves more than 10,000 patients and over 45,000 treatment sessions during a period of more than 280 treatment years...
January 2010: European Journal of Paediatric Neurology: EJPN
#23
MULTICENTER STUDY
A Meyer-Heim, C Ammann-Reiffer, A Schmartz, J Schäfer, F H Sennhauser, F Heinen, B Knecht, E Dabrowski, I Borggraefe
OBJECTIVE: To measure functional gait improvements of robotic-assisted locomotion training in children with cerebral palsy (CP). DESIGN: Single-case experimental A-B design. SETTINGS: Rehabilitation Centre Affoltern am Albis, Children's University Hospital Zurich, Switzerland (inpatient group) and Neurology Department of the Dr von Haunersches Children's Hospital Munich, Germany (outpatient group). PARTICIPANTS: 22 children (mean age 8...
August 2009: Archives of Disease in Childhood
#24
JOURNAL ARTICLE
I Borggraefe, K Boetzel, J Boehmer, S Berweck, W Mueller-Felber, K Mueller, J H Mehrkens, F Heinen
We report the case of an 8-year-old girl who developed progressive generalized dystonia, rendering her unable to walk and sit within months despite medical therapy with dopamine and anti-cholinergic agents. She was found to have a 9q34.1 GAG-deletion, which is known to cause DYT1-dystonia. DYT-1 dystonia is an autosomal dominant condition with incomplete penetrance that usually starts in childhood. It is known to be refractory to pharmacotherapy. Reports on deep brain stimulation in this condition reveal marked benefits of the treatment in the pediatric and adult populations...
August 2008: Neuropediatrics
#25
JOURNAL ARTICLE
Othmar Ludwiczek, Edouard Vannier, Alexander Moschen, Adriana Salazar-Montes, Ingo Borggraefe, Cem Gabay, Barbara Enrich, Arthur Kaser, Britta Siegmund, Charles Dinarello, Herbert Tilg
OBJECTIVE: To assess the production of the endogenous IL-1 modulators IL-1 receptor antagonist (IL-1Ra), type I and II soluble IL-1 receptors (IL-1sRI and II) in patients with chronic liver disease (CLD). MATERIAL AND METHODS: Plasma levels of IL-1beta (IL-1beta) and IL-1 modulators were assessed in 126 CLD patients and 39 healthy controls. IL-1sRII was also measured in the supernatants of primary hepatocyte cultures. RESULTS: Plasma IL-1sRI and IL-1Ra levels were significantly higher in cirrhotic CLD patients than in non-cirrhotic CLD patients and in controls...
2008: Scandinavian Journal of Gastroenterology
#26
COMPARATIVE STUDY
C Kamm, H Fischer, B Garavaglia, S Kullmann, M Sharma, C Schrader, K Grundmann, C Klein, I Borggraefe, E Lobsien, A Kupsch, N Nardocci, T Gasser
No abstract text is available yet for this article.
June 3, 2008: Neurology
#27
JOURNAL ARTICLE
F Hoffmann, K Reiter, G Kluger, H Holthausen, H P Schwarz, I Borggraefe, W Bonfig
Hashimoto encephalopathy (HE) is a rare steroid-responsive encephalopathy associated with elevated antithyroid antibodies and is a well recognised complication of autoimmune thyroid disease. The clinical picture is pleomorphic, presenting with variable symptoms like coma, seizures, neuropsychiatric changes (impairment of cognitive functions, behavioural and mood disturbances, hallucinations) or focal neurological deficits. HE is mainly diagnosed in adults, but also a rare differential diagnosis of encephalopathy or epilepsy in children...
August 2007: Neuropediatrics
#28
JOURNAL ARTICLE
A Meyer-Heim, I Borggraefe, C Ammann-Reiffer, St Berweck, F H Sennhauser, G Colombo, B Knecht, F Heinen
Intensive, task-specific training enabled by a driven gait orthosis (DGO) may be a cost-effective means of improving walking performance in children. A paediatric DGO has recently been developed. This study was the first paediatric trial aimed to determine the feasibility of robotic-assisted treadmill training in children with central gait impairment (n=26; 11 females, 15 males; mean age 10 y 1 mo [SD 4 y]; range 5 y 2 mo-19 y 5 mo). Diagnoses of the study group included cerebral palsy (n=19; Gross Motor Function Classification System Levels I-IV), traumatic brain injury (n=1), Guillain-Barré syndrome (n=2), incomplete paraplegia (n=2), and haemorrhagic shock (n=1), and encephalopathy (n=1)...
December 2007: Developmental Medicine and Child Neurology
#29
JOURNAL ARTICLE
O Ludwiczek, E Vannier, I Borggraefe, A Kaser, B Siegmund, C A Dinarello, H Tilg
Interleukin (IL)-1 is a key mediator in the pathogenesis of inflammatory bowel disease (IBD). Naturally occurring IL-1 modulators include IL-1 receptor antagonist (IL-1Ra), IL-1 soluble receptor Type I (IL-1sRI), IL-1sRII and IL-1 receptor accessory protein (AcP). Systemic and mucosal levels of IL-1 soluble receptors remain unknown in IBD. Plasma or colonic tissues were obtained from 185 consecutive unselected patients with Crohn's disease (CD) or ulcerative colitis (UC) and from 52 control subjects. Plasma and colonic explant culture supernatants were assessed for IL-1alpha, IL-1beta, IL-1Ra, IL-1sRI and IL-1sRII...
November 2004: Clinical and Experimental Immunology
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