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https://www.readbyqxmd.com/read/29665697/redox-control-of-angiogenesis
#1
Katrin Schröder
SIGNIFICANCE: Angiogenesis is the formation of new vessels that sprout from existing vessels. This process is highly complex and requires a coordinated shift of the endothelial phenotype from a quiescent cell in the vessel wall into a migrating or proliferating cell. Such change in the life of the endothelial cell is induced by a variety of factors such as hypoxia, metabolic changes or cytokines. CRITICAL ISSUES: According to the wide variety of stimuli that induce angiogenesis a complex signaling network is needed to support a coordinated response of the endothelial...
April 18, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29660342/investigation-of-trpv1-loss-of-function-phenotypes-in-trpv1-leu206stop-mice-generated-by-n-ethyl-n-nitrosourea-mutagenesis
#2
Thomas Christoph, Babette Kögel, Klaus Schiene, Thomas Peters, Wolfgang Schröder
N-ethyl-N-nitrosourea (ENU) random mutagenesis was used to generate a mouse model for the analysis of the transient receptor potential vanilloid 1 (TRPV1) cation channel. A transversion from T→A in exon 4 led to a Leu206Stop mutation generating a loss-of-function mutant. The TRPV1 agonist capsaicin was used to analyze functional and nociceptive parameters in vitro and in vivo in TRPV1 Leu206Stop mice and congenic C3HeB/FeJ controls. Capsaicin-induced [Ca2+ ]i changes in small diameter DRG neurons were significantly diminished in TRPV1 Leu206Stop mice and administration of capsaicin induced neither hypothermia nor nocifensive behaviour in vivo...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29651229/polycatenated-2d-hydrogen-bonded-binary-supramolecular-organic-frameworks-sofs-with-enhanced-gas-adsorption-and-selectivity
#3
Jian Lü, Cristina Perez-Krap, Fabien Trousselet, Yong Yan, Nada H Alsmail, Bahar Karadeniz, Nicholas M Jacques, William Lewis, Alexander J Blake, François-Xavier Coudert, Rong Cao, Martin Schröder
Controlled assembly of two-dimensional (2D) supramolecular organic frameworks (SOFs) has been demonstrated through a binary strategy in which 1,4-bis-(4-(3,5-dicyano-2,6-dipyridyl)pyridyl)naphthalene ( 2 ), generated in situ by oxidative dehydrogenation of 1,4-bis-(4-(3,5-dicyano-2,6-dipyridyl)dihydropyridyl)naphthalene ( 1 ), is coupled in a 1:1 ratio with terphenyl-3,3',4,4'-tetracarboxylic acid ( 3 ; to form SOF-8 ), 5,5'-(anthracene-9,10-diyl)diisophthalic acid ( 4 ; to form SOF-9 ), or 5,5'-bis-(azanediyl)-oxalyl-diisophthalic acid ( 5 ; to form SOF-10 )...
April 4, 2018: Crystal Growth & Design
https://www.readbyqxmd.com/read/29630046/multimodal-hierarchical-imaging-of-serial-sections-for-finding-specific-cellular-targets-within-large-volumes
#4
Irene U Wacker, Lisa Veith, Waldemar Spomer, Andreas Hofmann, Marlene Thaler, Stefan Hillmer, Ulrich Gengenbach, Rasmus R Schröder
Targeting specific cells at ultrastructural resolution within a mixed cell population or a tissue can be achieved by hierarchical imaging using a combination of light and electron microscopy. Samples embedded in resin are sectioned into arrays consisting of ribbons of hundreds of ultrathin sections and deposited on pieces of silicon wafer or conductively coated coverslips. Arrays are imaged at low resolution using a digital consumer like smartphone camera or light microscope (LM) for a rapid large area overview, or a wide field fluorescence microscope (fluorescence light microscopy (FLM)) after labeling with fluorophores...
March 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29625457/differentiation-patterns-of-immortalized-human-meibomian-gland-epithelial-cells-in-three-dimensional-culture
#5
Nagayoshi Asano, Ulrike Hampel, Fabian Garreis, Antje Schröder, Martin Schicht, Christian M Hammer, Friedrich Paulsen
Purpose: To establish a simplified three-dimensional (3D) meibomian gland culture model using a meibomian gland epithelial cell (HMGEC) line that might be a useful tool to gain deeper insights into meibomian gland dysfunction. For this purpose, 3D differentiation patterns and growth characteristics of HMGECs were studied on various membranes/scaffolds as well as in hanging drops. Methods: Several types of inserts consisting of different materials (Millicell-HA, Millicell-PCF, ThinCert, and Alvetex) as well as hanging drop culture were analyzed...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625330/use-of-torsional-resonators-to-monitor-electroactive-biofilms
#6
Phillipp Sievers, Christopher Moß, Uwe Schröder, Diethelm Johannsmann
Whereas the study of interfaces and thin films with the quartz crystal microbalance (QCM) is well established, biofilms have proven to be a difficult subject for the QCM. The main problem is that the shear wave emanating from the resonator surface does not usually reach to the top of the sample. This problem can be solved with torsional resonators. These have a resonance frequency in the range of tens of kHz, which is much below the frequency of the thickness-shear QCMs. The depth of penetration of the shear wave is correspondingly larger...
March 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29621046/persistent-physical-symptoms-as-perceptual-dysregulation-a-neuropsychobehavioral-model-and-its-clinical-implications
#7
Peter Henningsen, Harald Gündel, Willem J Kop, Bernd Löwe, Alexander Martin, Winfried Rief, Judith G M Rosmalen, Andreas Schröder, Christina van der Feltz-Cornelis, Omer Van den Bergh
OBJECTIVE: The mechanisms underlying the perception and experience of persistent physical symptoms are not well understood, and in the models, the specific relevance of peripheral input versus central processing, or of neurobiological versus psychosocial factors in general, is not clear.In this article, we propose a model for this clinical phenomenon that is designed to be coherent with an underlying, relatively new model of the normal brain functions involved in the experience of bodily signals...
April 4, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29615567/the-roles-of-the-wnt-antagonists-axin-and-lrp4-during-embryogenesis-of-the-red-flour-beetle-tribolium-castaneum
#8
Romy Prühs, Anke Beermann, Reinhard Schröder
In both vertebrates and invertebrates, the Wnt-signaling pathway is essential for numerous processes in embryogenesis and during adult life. Wnt activity is fine-tuned at various levels by the interplay of a number of Wnt-agonists (Wnt ligands, Frizzled-receptors, Lrp5/6 coreceptors) and Wnt-antagonists (among them Axin, Secreted frizzled and Lrp4) to define anterior-posterior polarity of the early embryo and specify cell fate in organogenesis. So far, the functional analysis of Wnt-pathway components in insects has concentrated on the roles of Wnt-agonists and on the Wnt-antagonist Axin...
October 15, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29604828/density-functional-theory-for-hard-uniaxial-particles-complex-ordering-of-pear-shaped-and-spheroidal-particles-near-a-substrate
#9
Philipp W A Schönhöfer, Gerd E Schröder-Turk, Matthieu Marechal
We develop a density functional for hard particles with a smooth uniaxial shape (including non-inversion-symmetric particles) within the framework of fundamental measure theory. By applying it to a system of tapered, aspherical liquid-crystal formers, reminiscent of pears, we analyse their behaviour near a hard substrate. The theory predicts a complex orientational ordering close to the substrate, which can be directly related to the particle shape, in good agreement with our simulation results. Furthermore, the lack of particle inversion-symmetry implies the possibility of alternating orientations in subsequent layers as found in a smectic/lamellar phase of such particles...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29602822/-18-f-fluoroestradiol-tumor-uptake-is-heterogeneous-and-influenced-by-site-of-metastasis-in-breast-cancer-patients
#10
Hilde H Nienhuis, Michel van Kruchten, Sjoerd G Elias, Andor W J M Glaudemans, Erik F J de Vries, Alfons H H Bongaerts, Carolien P Schröder, Elisabeth G E de Vries, Geke A P Hospers
Heterogeneity of estrogen receptor (ER) expression in breast cancer is recognized. However, knowledge about varying expression across metastases and surrounding normal tissue in patients is scarce. We therefore analyzed 16α-[18 F]-fluoro-17β-estradiol (18 F-FES) positron emission tomography (PET) to assess ER expression heterogeneity. Methods: 18 F-FES-PET on EARL accredited PET-CT camera systems performed in patients with ER positive metastatic breast cancer November 2009- December 2014 were analyzed. Lesions with maximum absolute standardized uptake value (SUVmax ) ≥ 1...
March 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29601205/efficient-extraction-of-light-from-a-nitrogen-vacancy-center-in-a-diamond-parabolic-reflector
#11
Noel Wan, Brendan Shields, Donggyu Kim, Sara Mouradian, Benjamin Lienhard, Michael Walsh, Hassaram Bakhru, Tim Schröder, Dirk Englund
Quantum emitters in solids are being developed for a range of quantum technologies, including quantum networks, computing, and sensing. However, a remaining challenge is the poor photon collection due to the high refractive index of most host materials. Here we overcome this limitation by introducing monolithic parabolic reflectors as an efficient geometry for broadband photon extraction from quantum emitter and experimentally demonstrate this device for the nitrogen-vacancy (NV) center in diamond. Simulations indicate a photon collection efficiency exceeding 75% across the visible spectrum and experimental devices, fabricated using a high-throughput gray-scale lithography process, demonstrate a photon extraction efficiency of (41±5)%...
March 30, 2018: Nano Letters
https://www.readbyqxmd.com/read/29601200/gluco-1h-imidazole-a-new-class-of-azole-type-%C3%AE-glucosidase-inhibitor
#12
Sybrin P Schröder, Liang Wu, Marta Artola, Thomas Hansen, Wendy A Offen, Maria J Ferraz, Kah-Yee Li, Johannes M F G Aerts, Gijsbert A van der Marel, Jeroen D C Codée, Gideon J Davies, Herman S Overkleeft
Gluco-azoles competitively inhibit glucosidases by transition-state mimicry and their ability to interact with catalytic acid residues in glucosidase active sites. We noted that no azole-type inhibitors described, to date, possess a protic nitrogen characteristic for 1H-imidazoles. Here, we present gluco-1H-imidazole, a gluco-azole bearing a 1H-imidazole fused to a glucopyranose-configured cyclitol core, and three close analogues as new glucosidase inhibitors. All compounds inhibit human retaining β-glucosidase, GBA1, with the most potent ones inhibiting this enzyme (deficient in Gaucher disease) on a par with glucoimidazole...
March 30, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29594495/evaluation-of-sentinel-lymph-node-biopsy-prior-to-axillary-lymph-node-dissection-the-role-of-isolated-tumor-cells-micrometastases-and-multifocality-multicentricity-a-retrospective-study-of-1214-breast-cancer-patients
#13
Lars Schröder, Roland Fricker, Roland Gregor Stein, Thomas Rink, Hartmut Fitz, Sebastian Blasius, Achim Wöckel, Thomas Müller
PURPOSE: Sentinel lymph node biopsy (SLNB) alone has thus become an accepted surgical approach for patients with limited axillary metastatic disease. We investigated to what extent isolated tumor cells (ITC) or micrometastasis in SLNBs is associated with proven tumor cells or metastasis in non-sentinel lymph nodes. Furthermore, we investigated the feasibility of SLNB in multifocal and multicentric tumors as both entities have been considered a contraindication for this technique. METHODS: 1214 women suffering from T1 and T2 invasive breast cancer, with clinically and sonographically insuspect axillary status and undergoing primary breast cancer surgery including SLNB and axillary staging in case of SLN (sentinel lymph node) metastases, were recruited into this multicentered study...
March 29, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29594290/an-aryl-fused-redox-active-tetrathiafulvalene-with-enhanced-mixed-valence-and-radical-cation-dimer-stabilities
#14
Hendrik V Schröder, Felix Witte, Marius Gaedke, Sebastian Sobottka, Lisa Suntrup, Henrik Hupatz, Arto Valkonen, Beate Paulus, Kari Rissanen, Biprajit Sarkar, Christoph A Schalley
Molecular recognition of stable organic radicals is a relatively novel, but important structural binding motif in supramolecular chemistry. Here, we report on a redox-switchable veratrole-fused tetrathiafulvalene derivative VTTF which is ideally suited for this purpose and for the incorporation into stimuli-responsive systems. As revealed by electrochemistry, UV/Vis measurements, X-ray analysis, and electrocrystallisation, VTTF can be reversibly oxidised to the corresponding radical-cation or dication which shows optoelectronic and structural propterties similar to tetrathiafulvalene and tetrakis(methylthio)tetrathiafulvalene...
March 29, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29594175/multiple-inflammasomes-may-regulate-the-interleukin-1-driven-inflammation-in-protracted-bacterial-bronchitis
#15
Alice C-H Chen, Hai B Tran, Yang Xi, Stephanie T Yerkovich, Katherine J Baines, Susan J Pizzutto, Melanie Carroll, Avril A B Robertson, Matthew A Cooper, Kate Schroder, Jodie L Simpson, Peter G Gibson, Greg Hodge, Ian B Masters, Helen M Buntain, Helen L Petsky, Samantha J Prime, Anne B Chang, Sandra Hodge, John W Upham
Protracted bacterial bronchitis (PBB) in young children is characterised by prolonged wet cough, prominent airway interleukin (IL)-1β expression and infection, often with nontypeable Haemophilus influenzae (NTHi). The mechanisms responsible for IL-1-driven inflammation in PBB are poorly understood. We hypothesised that the inflammation in PBB involves the NLRP3 and/or AIM2 inflammasome/IL-1β axis. Lung macrophages obtained from bronchoalveolar lavage (BAL), peripheral blood mononuclear cells (PBMCs), blood monocytes and monocyte-derived macrophages from patients with PBB and age-matched healthy controls were cultured in control medium or exposed to live NTHi...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29590400/perceptions-and-attitudes-regarding-antibiotic-resistance-in-germany-a-cross-sectoral-survey-amongst-physicians-veterinarians-farmers-and-the-general-public
#16
Sandra Schneider, Florian Salm, Szilvia Vincze, Anne Moeser, Inga Petruschke, Katja Schmücker, Norman Ludwig, Regina Hanke, Christin Schröder, Alexander Gropmann, Michael Behnke, Antina Lübke-Becker, Lothar H Wieler, Stefan Hagel, Mathias W Pletz, Jochen Gensichen, Petra Gastmeier
Background: Drivers of antibiotic (AB) resistance (ABR) include outpatient treatment, hospital care and animal husbandry. During the first phase of the One Health project RAI (Responsible Antibiotic Use via Information and Communication) surveys were conducted in these sectors. Objectives: To compare perceptions and attitudes towards ABR among general practitioners (GPs), hospital physicians, veterinarians, pig farmers and the general public. Methods: Cross-sectional questions on AB use and ABR were integrated in group-specific surveys of GPs, hospital physicians, veterinarians, pig farmers and the German general population...
March 26, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29582897/dietary-restriction-ameliorates-age-related-increase-in-dna-damage-senescence-and-inflammation-in-mouse-adipose-tissuey
#17
A Ishaq, J Schröder, N Edwards, T von Zglinicki, G Saretzki
Ageing is associated with redistribution of fat around the body and saturation of visceral adipose depots. Likewise, the presence of excess fat in obesity or during ageing places extra stress on visceral depots, resulting in chronic inflammation and increased senescence. This process can contribute to the establishment of the metabolic syndrome and accelerated ageing. Dietary restriction (DR) is known to alleviate physiological signs of inflammation, ageing and senescence in various tissues including adipose tissue...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29567385/-a-structured-case-analysis-from-the-critical-incident-reporting-system-of-the-german-medical-association-and-the-national-association-of-statutory-health-insurance-physicians
#18
Thomas Schrader, Laura Tetzlaff, Katharina Löwe, Cornelia Schröder, Eberhard Beck
BACKGROUND: Reporting systems for near misses are necessary to improve patient safety. In Germany, different systems are publicly available on both a national and regional level or as systems related to various medical domains. In contrast with the British Registry, our reporting systems still lack systematic evaluation. Using the Open-Task-Process Model (OPT model) one case of CIRSmedical (www.cirsmedical.de) was selected for a systematic analysis. METHOD: Case 148384 reports on a patient with a tentative diagnosis of pulmonary embolism with an oxygen saturation of 71 %...
March 19, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29560036/metal-artefacts-severely-hamper-magnetic-resonance-imaging-of-the-rotator-cuff-tendons-after-rotator-cuff-repair-with-titanium-suture-anchors
#19
Femke F Schröder, Rianne Huis In't Veld, Lydia A den Otter, Sjoerd M van Raak, Bennie Ten Haken, Anne J H Vochteloo
Background: The rate of retear after rotator cuff surgery is 17%. Magnetic resonance imaging (MRI) scans are used for confirmative diagnosis of retear. However, because of the presence of titanium suture anchors, metal artefacts on the MRI are common. The present study evaluated the diagnostic value of MRI after rotator cuff tendon surgery with respect to assessing the integrity as well as the degeneration and atrophy of the rotator cuff tendons when titanium anchors are in place. Methods: Twenty patients who underwent revision surgery of the rotator cuff as a result of a clinically suspected retear between 2013 and 2015 were included...
April 2018: Shoulder & Elbow
https://www.readbyqxmd.com/read/29557314/-hans-heinze-and-the-research-programme-of-the-german-association-of-child-psychiatry-and-therapeutic-education-1942-1945
#20
Klaus Schepker, Thomas Beddies
Hans Heinze and the Research Programme of the German Association of Child Psychiatry and Therapeutic Education 1942-1945 Upon its foundation in 1940, Paul Schröder, full professor for psychiatry in Leipzig, was the first president of the German Society for Child Psychiatry and Therapeutic Education (DGKH). Following his death in 1941, his student Hans Heinze (Brandenburg/H.) succeeded him, prevailing over Werner Villinger (Breslau). The principal task of the DGKH was considered to be the exploration of the genetic origins of intellectual disabilities and behavioural disorders among children and adolescents...
September 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
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