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Schröder AS

David Gøttsche, Thomas Lind, Thorbjørn Christiansen, Henrik M Schrøder
INTRODUCTION: Revision total knee arthroplasty with a cementless metaphyseal sleeve is suggested to be used without stem in revision total knee arthroplasty (rTKA). To the best of our knowledge, no papers investigating this have been published. The purpose of this study was to evaluate clinical outcome. METHOD: In this retrospective study, 71 patients operated with rTKA with sleeves without stem in the period 2009-2011 were identified; 63 were examined. All patients with the prosthesis still in place were invited to a medical examination including X-rays...
October 19, 2016: Archives of Orthopaedic and Trauma Surgery
Christian Scheele, Matthias F Pietschmann, Christian Schröder, Thomas Grupp, Melanie Holderied, Volmar Jansson, Peter E Müller
BACKGROUND: Unicompartmental total knee arthroplasty (UKA) is a well-established treatment option for unicondylar osteoarthritis, and generally leads to better functional results than tricompartimental total knee arthroplasty (TKA). However, revision rates of UKAs are reported as being higher; a major reason for this is aseptic loosening of the tibial component due to implant-cement-bone interface fatigue. The objective of this study was to determine the effects of trabecular bone preparation, prior to implantation of tibial UKAs, on morphological and biomechanical outcomes in a cadaver study...
October 16, 2016: Knee
Frieder Hofmann, Maren Kruse-Plass, Ulrike Kuhn, Mathias Otto, Ulrich Schlechtriemen, Boris Schröder, Rudolf Vögel, Werner Wosniok
BACKGROUND: Risk assessment for GMOs such as Bt maize requires detailed data concerning pollen deposition onto non-target host-plant leaves. A field study of pollen on lepidopteran host-plant leaves was therefore undertaken in 2009-2012 in Germany. During the maize flowering period, we used in situ microscopy at a spatial resolution adequate to monitor the feeding behaviour of butterfly larvae. The plant-specific pollen deposition data were supplemented with standardised measurements of pollen release rates and deposition obtained by volumetric pollen monitors and passive samplers...
2016: Environmental Sciences Europe
Lennard Schröder, Dagmar Ulrike Richter, Birgit Piechulla, Mareike Chrobak, Christina Kuhn, Sandra Schulze, Sybille Abarzua, Udo Jeschke, Tobias Weissenbacher
Hereinwe investigated the effect of elderflower extracts (EFE) and of enterolactone/enterodiol on hormone production and proliferation of trophoblast tumor cell lines JEG-3 and BeWo, as well as MCF7 breast cancer cells. The EFE was analyzed by mass spectrometry. Cells were incubated with various concentrations of EFE. Untreated cells served as controls. Supernatants were tested for estradiol production with an ELISA method. Furthermore, the effect of the EFE on ER/ER/PR expression was assessed by immunocytochemistry...
October 8, 2016: Nutrients
Rico D Bense, Christos Sotiriou, Martine J Piccart-Gebhart, John B A G Haanen, Marcel A T M van Vugt, Elisabeth G E de Vries, Carolien P Schröder, Rudolf S N Fehrmann
BACKGROUND: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy, resulting in considerable undertreatment or overtreatment. New insights into the role of tumor-infiltrating immune cells suggest that their composition, as well as their functionality, might serve as a biomarker to enable optimal patient selection for current systemic therapies and upcoming treatment options such as immunotherapy. METHODS: We performed several complementary unbiased in silico analyses on gene expression profiles of 7270 unrelated tumor samples of nonmetastatic breast cancer patients with known clinical follow-up...
January 2017: Journal of the National Cancer Institute
Hal D Martin, Anthony N Khoury, Ricardo Schröder, Eric Johnson, Juan Gómez-Hoyos, Salvador Campos, Ian J Palmer
PURPOSE: To determine the isolated function of the pubofemoral ligament of the hip capsule and its contribution to hip stability in external/internal rotational motion during flexion greater than 30° and abduction. METHODS: Thirteen hips from 7 fresh-frozen pelvis-to-toe cadavers were skeletonized from the lumbar spine to the distal femur with the capsular ligaments intact. Computed tomographic imaging was performed to ensure no occult pathological state existed, and assess bony anatomy...
October 5, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Louisiana Carolina Ferreira de Meireles, Karine Bertoldi, Laura Reck Cechinel, Bruna Luisa Schallenberger, Vanessa Kappel da Silva, Nadja Schröder, Ionara Rodrigues Siqueira
Physical exercise and the aging process have been shown to induce opposite effects on epigenetic marks, such as histone acetylation. The impact of exercise on hippocampal histone acetylation on specific lysine residues, especially during the aging process, is rarely studied. The aim of this study was to investigate the effect of treadmill exercise (20min/day during 2 weeks) on H3K9, H4K5 and H4K12 acetylation levels in hippocampi of young adult and aged rats. Male Wistar rats aged 3 or 20-21 months were assigned to sedentary and exercise groups...
October 4, 2016: Neuroscience Letters
Danila A Barskiy, Aaron M Coffey, Panayiotis Nikolaou, Dmitry M Mikhaylov, Boyd M Goodson, Rosa T Branca, George J Lu, Mikhail G Shapiro, Ville-Veikko Telkki, Vladimir V Zhivonitko, Igor V Koptyug, Oleg G Salnikov, Kirill V Kovtunov, Valerii I Bukhtiyarov, Matthew S Rosen, Michael J Barlow, Shahideh Safavi, Ian P Hall, Leif Schröder, Eduard Y Chekmenev
Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection...
October 6, 2016: Chemistry: a European Journal
Elisa Schröder, Hendrik Kajosch, Paul Verbanck, Charles Kornreich, Salvatore Campanella
Event-related potentials (ERPs) bimodal oddball task has disclosed increased sensitivity to show P300 modulations to subclinical symptoms. Even if the utility of such a procedure has still to be confirmed at a clinical level, gathering normative values of this new oddball variant may be of the greatest interest. We specifically addressed the challenge of defining the best location for the recording of P3a and P3b components and selecting the best reference to use by investigating the effect of an offline re-reference procedure on recorded bimodal P3a and P3b...
2016: Frontiers in Psychology
Nicholas Glanville, Tamlyn J Peel, Armin Schröder, Julia Aniscenko, Ross P Walton, Susetta Finotto, Sebastian L Johnston
Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associated with increased RV-induced asthma exacerbation severity. We examined the contribution of T helper 1 cells to RV-induced airways inflammation using mice deficient in the transcription factor T-Box Expressed In T Cells (Tbet), a critical controller of T helper 1 cell differentiation...
September 2016: PLoS Pathogens
Lykke Schrøder Jakobsen, Sissel Lundemose, Jytte Banner, Niels Lynnerup, Christina Jacobsen
PURPOSE: The purpose of this study was to investigate the utility of postmortem computed tomography (PMCT) images in estimating organ sizes and to examine the use of the cardiothoracic ratio (CTR). METHODS: We included 45 individuals (19 females), who underwent a medico-legal autopsy. Using the computer software program Mimics(®), we determined in situ heart and liver volumes derived from linear measurements (width, height and depth) on a whole body PMCT-scan, and compared the volumes with ex vivo volumes derived by CT-scan of the eviscerated heart and liver...
September 28, 2016: Forensic Science, Medicine, and Pathology
Mikkel Rathsach Andersen, Nikolaj Winther, Thomas Lind, Henrik SchrøDer, Gunnar Flivik, Michael Mørk Petersen
Background and purpose - Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of 2 different tibial component designs, monoblock and modular polyethylene, on migration of the tibial component in uncemented TKA...
September 20, 2016: Acta Orthopaedica
Ewa A Mirecka, Sophie Feuerstein, Lothar Gremer, Gunnar F Schröder, Matthias Stoldt, Dieter Willbold, Wolfgang Hoyer
In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of islet cell transplantation. Rational design of inhibitors of IAPP amyloid formation has therapeutic potential, but is hampered by the lack of structural information on inhibitor complexes of the conformationally flexible, aggregation-prone IAPP. Here we characterize a β-hairpin conformation of IAPP in complex with the engineered binding protein β-wrapin HI18...
2016: Scientific Reports
Thies Lüdtke, Levente Kriston, Johanna Schröder, Tania M Lincoln, Steffen Moritz
BACKGROUND AND OBJECTIVES: Negative affect and a tendency to "jump to conclusions" (JTC) are associated with paranoia. So far, only negative affect has been examined as a precursor of subsequent paranoia in daily life using experience sampling (ESM). We addressed this research gap and used ESM to test whether JTC fluctuates in daily life, whether it predicts subsequent paranoia, and whether it mediates the effect of negative affect on paranoia. METHODS: Thirty-five participants with schizophrenia spectrum disorders repeatedly self-reported negative affect, JTC, and paranoia via online questionnaires on two consecutive days...
August 31, 2016: Journal of Behavior Therapy and Experimental Psychiatry
Cynthia M June, Taylor J Muckenthaler, Emma C Schroder, Zachary L Klamer, Zdzislaw Wawrzak, Rachel A Powers, Agnieszka Szarecka, David A Leonard
OXA-51 is a class D β-lactamase that is thought to be the native carbapenemase of Acinetobacter baumannii. Many variants of OXA-51 containing active site substitutions have been identified from A. baumannii isolates, and some of these substitutions increase hydrolytic activity toward carbapenem antibiotics. We have determined the high-resolution structures of apo OXA-51 and OXA-51 with one such substitution (I129L) with the carbapenem doripenem trapped in the active site as an acyl-intermediate. The structure shows that acyl-doripenem adopts an orientation very similar to carbapenem ligands observed in the active site of OXA-24/40 (doripenem) and OXA-23 (meropenem)...
September 16, 2016: Protein Science: a Publication of the Protein Society
Karen Hansen Kallesøe, Andreas Schröder, Rikard K Wicksell, Per Fink, Eva Ørnbøl, Charlotte Ulrikka Rask
INTRODUCTION: Functional somatic syndromes (FSS) are common in adolescents, characterised by severe disability and reduced quality of life. Behavioural treatments such as acceptance and commitment therapy (ACT) has shown promising results in children and adolescents with FSS, but has focused on specific syndromes such as functional pain. The current study will compare the efficacy of group-based ACT with that of enhanced usual care (EUC) in adolescents with a range of FSS operationalised by the unifying construct of multiorgan bodily distress syndrome (BDS)...
September 15, 2016: BMJ Open
Luisa Roch, Michael Hecker, Jörg Friess, Ines Charlotte Angerer, Dirk Koczan, Brit Fitzner, Ina Schröder, Kristin Flechtner, Hans-Jürgen Thiesen, Stefanie Meister, Alexander Winkelmann, Uwe Klaus Zettl
Fingolimod, a sphingosine-1-phosphate (S1P) receptor modulator, is an oral drug approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). It selectively inhibits the egress of lymphocytes from lymph nodes. We studied the changes in the transcriptome of peripheral blood CD8(+) cells to unravel the effects at the molecular level during fingolimod therapy. We separated CD8(+) cells from the blood of RRMS patients before the first dose of fingolimod as well as 24 h and 3 months after the start of therapy...
September 8, 2016: Molecular Neurobiology
Sergey A Dyshlovoy, Katharina Otte, Winfried H Alsdorf, Jessica Hauschild, Tobias Lange, Simone Venz, Christiane K Bauer, Robert Bähring, Kerstin Amann, Ramin Mandanchi, Udo Schumacher, Jennifer Schröder-Schwarz, Tatyana N Makarieva, Alla G Guzii, Kseniya M Tabakmakher, Sergey N Fedorov, Larisa K Shubina, Igor E Kasheverov, Heimo Ehmke, Thomas Steuber, Valentin A Stonik, Carsten Bokemeyer, Friedemann Honecker, Gunhild von Amsberg
Development of drug resistance is an inevitable phenomenon in castration-resistant prostate cancer (CRPC) cells requiring novel therapeutic approaches. In this study, efficacy and toxicity of Rhizochalinin (Rhiz) - a novel sphingolipid-like marine compound - was evaluated in prostate cancer models, resistant to currently approved standard therapies. In vitro activity and mechanism of action of Rhiz were examined in the human prostate cancer cell lines PC-3, DU145, LNCaP, 22Rv1, and VCaP. Rhiz significantly reduced cell viability at low micromolar concentrations showing most pronounced effects in enzalutamide and abiraterone resistant AR-V7 positive cells...
September 10, 2016: Oncotarget
Bruno Gonçalves Schröder E Souza, Tiago Evangelista de Melo, Tales Pereira Lisboa, Marcos Bastos Miranda, Thiago Gonçalves Schroder E Souza, Valdeci Manoel de Oliveira
OBJECTIVE: to obtain information about the current knowledge and habits of parents who transport children in cars in Brazil. METHODS: a cross-sectional survey was conducted using specifically designed self-responded questionnaires, to parents of children attending a private pediatric office in town in southwest Brazil. Data was collected about children's age, gender, height and weight, possession of automobile children's restraint systems (CRS), its type, frequency and adequacy of use, reasons for not possessing or not using the devices...
September 13, 2016: Traffic Injury Prevention
Helmut Schröder, Santiago F Gomez, Lourdes Ribas-Barba, Carmen Pérez-Rodrigo, Rowaedh Ahmed Bawaked, Montserrat Fíto, Lluis Serra-Majem
BACKGROUND: Using a food-based analysis, healthy dietary patterns in adults are more expensive than less healthy ones; studies are needed in youth. Therefore, the objective of the present study was to determine relationships between monetary daily diet cost, diet quality, and parental socioeconomic status. DESIGN AND METHODS: Data were obtained from a representative national sample of 3534 children and young people in Spain, aged 2 to 24 years. Dietary assessment was performed with a 24-hour recall...
2016: PloS One
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