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https://www.readbyqxmd.com/read/28820590/conformational-heterogeneity-in-a-fully-complementary-dna-three-way-junction-with-a-gc-rich-branchpoint
#1
Anita Toulmin, Laura E Baltierra-Jasso, Michael J Morten, Tara Sabir, Peter McGlynn, Gunnar F Schröder, Brian O Smith, Steven W Magennis
DNA three-way junctions (3WJs) are branched structures that serve as important biological intermediates and as components in DNA nanostructures. We recently derived the global structure of a fully-complementary 3WJ and found that it contained unpaired bases at the branchpoint, in support of previous observations of branch flexibility and branchpoint reactivity. By combining high-resolution single-molecule FRET, molecular modeling, time-resolved ensemble fluorescence spectroscopy and the first 19F NMR observations of fully complementary 3WJs, we now show that the 3WJ structure can adopt multiple distinct conformations depending upon the sequence at the branchpoint...
August 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28814899/irritable-bowel-symptoms-and-the-development-of-common-mental-disorders-and-functional-somatic-syndromes-identified-in-secondary-care-a-long-term-population-based-study
#2
Chalotte Heinsvig Poulsen, Lene Falgaard Eplov, Carsten Hjorthøj, Marie Eliasen, Sine Skovbjerg, Thomas Meinertz Dantoft, Andreas Schröder, Torben Jørgensen
OBJECTIVE: Irritable bowel syndrome (IBS) is associated with mental vulnerability, and half of patients report comorbid somatic and mental symptoms. We aimed to investigate the relationship between an IBS symptom continuum and the subsequent development of common mental disorders (CMDs) and functional somatic syndromes (FSSs). METHODS AND STUDY DESIGN: A longitudinal population-based study comprising two 5-year follow-up studies, Dan-MONICA 1 (1982-1987) and Inter99 (1999-2004), recruited from the western part of Copenhagen County...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28802656/rethinking-papillary-muscle-resection-for-refractory-ventricular-tachycardia-in-the-lvad-era-a-case-report
#3
Zachary J Il'Giovine, Adam D DeVore, Chetan B Patel, Jason Koontz, Jacob Schroder
We report the case of a 57-year-old man with a history of ischemic cardiomyopathy who presented to the hospital with recurrent episodes of ventricular tachycardia refractory to antiarrhythmic medications. Mapping identified a deep premature ventricular contraction focus in the anterolateral papillary muscle, an area that has been previously identified as difficult to treat with radiofrequency catheter ablation. The hospital course was complicated by cardiogenic shock and VT-storm, and the patient ultimately underwent surgical resection of the anterolateral papillary muscle with left ventricular assist device placement as a successful bridge to cardiac transplantation...
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28797829/time-to-remission-from-mild-to-moderate-depressive-symptoms-one-year-results-from-the-evident-study-an-rct-of-an-internet-intervention-for-depression
#4
Jan Philipp Klein, Christina Späth, Johanna Schröder, Björn Meyer, Wolfgang Greiner, Martin Hautzinger, Wolfgang Lutz, Matthias Rose, Eik Vettorazzi, Gerhard Andersson, Fritz Hohagen, Steffen Moritz, Thomas Berger
BACKGROUND: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period. METHODS: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months...
July 21, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28796646/defining-benchmarks-for-transthoracic-esophagectomy-a-multicenter-analysis-of-total-minimally-invasive-esophagectomy-in-low-risk-patients
#5
Henner M Schmidt, Susanne S Gisbertz, Johnny Moons, Ioannis Rouvelas, Juha Kauppi, Andrew Brown, Emanuele Asti, Misha Luyer, Sjoerd M Lagarde, Felix Berlth, Annouck Philippron, Christiane Bruns, Arnulf Hölscher, Paul M Schneider, Dimitri A Raptis, Mark I van Berge Henegouwen, Philippe Nafteux, Magnus Nilsson, Jari Räsanen, Francesco Palazzo, Ernest Rosato, Stuart Mercer, Luigi Bonavina, Grard Nieuwenhuijzen, Bas P L Wijnhoven, Wolfgang Schröder, Piet Pattyn, Peter P Grimminger, Christian A Gutschow
OBJECTIVE: To define "best possible" outcomes in total minimally invasive transthoracic esophagectomy (ttMIE). BACKGROUND: TtMIE, performed by experts in patients with low comorbidity, may serve as a benchmark procedure for esophagectomy. PATIENTS AND METHODS: From a cohort of 1057 ttMIE, performed over a 5-year period in 13 high-volume centers for esophageal surgery, we selected a study group of 334 patients (31.6%) that fulfilled criteria of low comorbidity (American Society of Anesthesiologists score ≤2, WHO/ECOG score ≤1, age ≤65 years, body mass index 19-29 kg/m)...
August 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28777818/gluc-het-a-complementary-chick-embryo-model-for-the-characterization-of-antidiabetic-compounds
#6
Renate Haselgrübler, Flora Stübl, Katja Essl, Marcus Iken, Klaus Schröder, Julian Weghuber
Insulin resistance and β cell failure are the main causes of elevated blood glucose levels in Type 2 diabetes mellitus (T2DM), a complex and multifactorial metabolic disease. Several medications to treat or reduce the symptoms of T2DM are used, including the injection of insulin and the application of insulin sensitizing or glucose production reducing drugs. Furthermore, the use of phytochemicals has attracted increasing attention for the therapy and prevention of T2DM. In order to identify and characterize antidiabetic compounds, efficient test systems are required...
2017: PloS One
https://www.readbyqxmd.com/read/28772068/porous-metal-organic-polyhedral-frameworks-with-optimal-molecular-dynamics-and-pore-geometry-for-methane-storage
#7
Yong Yan, Daniil I Kolokolov, Ivan da Silva, Alexander G Stepanov, Alexander J Blake, Anne Dailly, Pascal Manuel, Chiu C Tang, Sihai Yang, Martin Schröder
Natural gas (methane, CH4) is widely considered as a promising energy carrier for mobile applications. Maximising the storage capacity is the primary goal for the design of future storage media. Here we report the CH4 storage properties in a family of isostructural (3,24)-connected porous materials, MFM-112a, MFM-115a and MFM-132a with different linker backbone functionalisation. Both MFM-112a and MFM-115a show excellent CH4 uptakes of 236 and 256 cm3 (STP) cm-3 (v/v) at 80 bar and room temperature, respectively...
August 3, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28770290/inorganic-polyphosphate-induces-accelerated-tube-formation-of-huvec-endothelial-cells
#8
Werner E G Müller, Maximilian Ackermann, Shunfeng Wang, Meik Neufurth, Rafael Muñoz-Espí, Qingling Feng, Heinz C Schröder, Xiaohong Wang
In this study, the effect of inorganic polyphosphate (polyP) on the initial phase of angiogenesis and vascularization was investigated, applying the HUVEC cell tube formation assay. PolyP is a physiological and high energy phosphate polymer which has been proposed to act as a metabolic fuel in the extracellular space with only a comparably low ATP content. The experiments revealed that polyP accelerates tube formation of human umbilical vein endothelial cells (HUVEC), seeded onto a solidified basement membrane extract matrix which contains polyP-metabolizing alkaline phosphatase (ALP) activity...
August 2, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28753696/colorectal-endoscopic-full-thickness-resection-using-a-novel-flat-base-over-the-scope-clip-a-prospective-study
#9
Yara Backes, Wouter F W Kappelle, Luuk Berk, Arjun D Koch, John N Groen, Wouter H de Vos Tot Nederveen Cappel, Matthijs P Schwartz, Marjon Kerkhof, Peter D Siersema, Roland Schröder, T G Tan, Miangela M Lacle, Frank P Vleggaar, Leon M G Moons
Background and study aims We aimed to evaluate the feasibility and safety of a new, flat-based over-the-scope clip (Padlock Clip) for colorectal endoscopic full-thickness resection (eFTR). Patients and methods We prospectively included 26 patients with lesions < 20 mm. Indications for eFTR were re-resection of the scar of a low risk malignant polyp (n = 11), recurrent adenoma in a non-lifting scar (n = 10), non-lifting polyp (n = 4), and an adenoma located in a diverticulum (n = 1)...
July 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28750513/a-dna-walker-as-a-fluorescence-signal-amplifier
#10
Dongfang Wang, Carolin Vietz, Tim Schröder, Guillermo Acuna, Birka Lalkens, Philip Tinnefeld
Sensing nucleic acids typically involves the recognition of a specific sequence and reporting by, for example, a fluorogenic reaction yielding one activated dye molecule per detected nucleic acid. Here, we show that after binding to a DNA origami track a bound DNA target (a "DNA walker") can release the fluorescence of many molecules by acting as the catalyst of an enzymatic nicking reaction. As the walking kinetics sensitively depends on the walker sequence, the resulting brightness distribution of DNA origamis is a sequence fingerprint with single-nucleotide sensitivity...
August 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/28745069/a-case-series-of-pls-patients-with-frontotemporal-dementia-and-overview-of-the-literature
#11
Bálint S de Vries, Laura M M Rustemeijer, Anneke J van der Kooi, Joost Raaphorst, Carin D Schröder, Tanja C W Nijboer, Jeroen Hendrikse, Jan H Veldink, Leonard H van den Berg, Michael A van Es
OBJECTIVE: Primary lateral sclerosis (PLS) is a rare form of motor neuron disease characterised by UMN degeneration leading to slowly progressive spasticity. Whether it is a separate disease or a subtype of ALS has been debated. In ALS comorbid frontotemporal dementia (FTD) is frequently seen (±15%). However, cognitive and behavioural changes are generally not considered to be a part of PLS. METHODS: To report the clinical findings and frequency of PLS patients that developed FTD in a referral-based cohort and provide an overview of the literature...
July 26, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28745053/development-of-a-maldi-tof-ms-based-protein-fingerprint-database-of-common-food-fish-allowing-fast-and-reliable-identification-of-fraud-and-substitution
#12
Antje Stahl, Uwe Schröder
Fish substitution and fish fraud are widely observed on the global food market. To detect and prevent substitution, DNA-based methods do not always meet the demand of being time- and cost-efficient; therefore, methodology improvements are needed. The use of species-specific protein patterns, as determined by matrix-assisted laser desorption/ ionization time-of-flight (MALDI-TOF) mass spectrometry has recently improved species identification of prokaryotes, both time- and cost-wise. We have used the method to establish a database containing protein patterns of common food fish prone to substitution...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28740753/a-laid-back-trip-through-the-hennigian-forests
#13
Evgeny V Mavrodiev, Christopher Dell, Laura Schroder
BACKGROUND: This paper is a comment on the idea of matrix-free Cladistics. Demonstration of this idea's efficiency is a major goal of the study. Within the proposed framework, the ordinary (phenetic) matrix is necessary only as "source" of Hennigian trees, not as a primary subject of the analysis. Switching from the matrix-based thinking to the matrix-free Cladistic approach clearly reveals that optimizations of the character-state changes are related not to the real processes, but to the form of the data representation...
2017: PeerJ
https://www.readbyqxmd.com/read/28733442/-89-zr-lumretuzumab-pet-imaging-before-and-during-her3-antibody-lumretuzumab-treatment-in-patients-with-solid-tumors
#14
Frederike Bensch, Laetitia E Lamberts, Michaël M Smeenk, Annelies Jorritsma-Smit, Marjolijn N Lub-de Hooge, Anton G T Terwisscha van Scheltinga, Johan R de Jong, Jourik A Gietema, Carolina P Schröder, Marlene Thomas, Wolfgang Jacob, Keelara Abiraj, Celine Adessi, Georgina Meneses-Lorente, Ian James, Martin Weisser, Adrienne H Brouwers, Elisabeth G de Vries
Purpose: We evaluated biodistribution and tumor targeting of (89)Zr-lumretuzumab before and during treatment with lumretuzumab, a human epidermal growth factor receptor 3 (HER3)-targeting monoclonal antibody. <p>Experimental design: 20 patients with histologically confirmed HER3-expressing tumors received (89)Zr-lumretuzumab and underwent Positron Emission Tomography (PET). In Part A, (89)Zr-lumretuzumab was given with additional, escalating doses of unlabeled lumretuzumab and scans were performed 2, 4 and 7 days postinjection to determine optimal imaging conditions...
July 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28728542/clove-classification-of-genomic-fusions-into-structural-variation-events
#15
Jan Schröder, Adrianto Wirawan, Bertil Schmidt, Anthony T Papenfuss
BACKGROUND: A precise understanding of structural variants (SVs) in DNA is important in the study of cancer and population diversity. Many methods have been designed to identify SVs from DNA sequencing data. However, the problem remains challenging because existing approaches suffer from low sensitivity, precision, and positional accuracy. Furthermore, many existing tools only identify breakpoints, and so not collect related breakpoints and classify them as a particular type of SV. Due to the rapidly increasing usage of high throughput sequencing technologies in this area, there is an urgent need for algorithms that can accurately classify complex genomic rearrangements (involving more than one breakpoint or fusion)...
July 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28725938/declining-radiation-dose-of-coronary-computed-tomography-angiography-german-cardiac-ct-registry-experience-2009-2014
#16
Axel Schmermund, Mohamed Marwan, Jörg Hausleiter, Sebastian Barth, Oliver Bruder, Sebastian Kerber, Grigorius Korosoglou, Alexander Leber, Werner Moshage, Stephen Schröder, Steffen Schneider, Jochen Senges, Stephan Achenbach
BACKGROUND: Coronary computed tomography angiography (CTA) is increasingly used as a test to rule out coronary artery disease (CAD) in patients with a low to intermediate pre-test probability of the disease. We used the database of the German CT registry, collected between 2009 and 2014 in a broad patient population, to analyze contemporary radiation dose associated with coronary CTA in clinical practice. PATIENTS AND METHODS: The prospective observational registry included a total of 7061 patients ≥18 years, referred to 12 participating centers for a clinically indicated cardiac CT examination...
July 19, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28724584/vcp-related-multisystem-proteinopathy-presenting-as-early-onset-parkinson-disease
#17
Martin Regensburger, Matthias Türk, Axel Pagenstecher, Rolf Schröder, Jürgen Winkler
No abstract text is available yet for this article.
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28723569/xiap-loss-triggers-ripk3-and-caspase-8-driven-il-1%C3%AE-activation-and-cell-death-as-a-consequence-of-tlr-myd88-induced-ciap1-traf2-degradation
#18
Kate E Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A Conos, Kaiwen W Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A Nguyen, Cathrine Hall, Angelina J Vince, Simon M Chatfield, Damian B D'Silva, Kenneth C Pang, Kate Schroder, John Silke, David L Vaux, Philipp J Jost, James E Vince
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP suppresses these events remains unclear. Here, we show that TLR-MyD88 causes the proteasomal degradation of the related IAP, cIAP1, and its adaptor, TRAF2, by inducing TNF and TNF Receptor 2 (TNFR2) signaling. Genetically, we define that myeloid-specific cIAP1 loss promotes TLR-induced RIPK3-caspase-8 and IL-1β activity in the absence of XIAP...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28716715/functional-parcellation-using-time-courses-of-instantaneous-connectivity
#19
REVIEW
Erik S B van Oort, Maarten Mennes, Tobias Navarro Schröder, Vinod J Kumar, Nestor I Zaragoza Jimenez, Wolfgang Grodd, Christian F Doeller, Christian F Beckmann
Functional neuroimaging studies have led to understanding the brain as a collection of spatially segregated functional networks. It is thought that each of these networks is in turn composed of a set of distinct sub-regions that together support each network's function. Considering the sub-regions to be an essential part of the brain's functional architecture, several strategies have been put forward that aim at identifying the functional sub-units of the brain by means of functional parcellations. Current parcellation strategies typically employ a bottom-up strategy, creating a parcellation by clustering smaller units...
July 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28715695/new-liver-cancer-biomarkers-pi3k-akt-mtor-pathway-members-and-eukaryotic-translation-initiation-factors
#20
Nicole Golob-Schwarzl, Stefanie Krassnig, Anna M Toeglhofer, Young Nyun Park, Margit Gogg-Kamerer, Klemens Vierlinger, Fabian Schröder, Hyungjn Rhee, Rudolf Schicho, Peter Fickert, Johannes Haybaeck
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The initiation of protein translation is an important rate-limiting step in eukaryotes and is crucial in many viral infections. Eukaryotic translation initiation factors (eIFs) are involved in the initiation step of protein translation and are linked to the phosphatidylinositol-3-kinases PI3K/AKT/mTOR pathway. Therefore we aimed to investigate a potential role of eIFs in HCC. We herein report on the immunohistochemical expression of the various eIF subunits in 235 cases of virus-related human HCC...
July 14, 2017: European Journal of Cancer
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