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https://www.readbyqxmd.com/read/28102353/cofilin-regulates-nuclear-architecture-through-a-myosin-ii-dependent-mechanotransduction-module
#1
O'Neil Wiggan, Bryce Schroder, Diego Krapf, James R Bamburg, Jennifer G DeLuca
Structural features of the nucleus including shape, size and deformability impact its function affecting normal cellular processes such as cell differentiation and pathological conditions such as tumor cell migration. Despite the fact that abnormal nuclear morphology has long been a defining characteristic for diseases such as cancer relatively little is known about the mechanisms that control normal nuclear architecture. Mounting evidence suggests close coupling between F-actin cytoskeletal organization and nuclear morphology however, mechanisms regulating this coupling are lacking...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102108/readiness-to-change-as-a-moderator-of-therapy-outcome-in-patients-with-somatoform-disorders
#2
Jens Heider, Katharina Köck, Matthias Sehlbrede, Annette Schröder
OBJECTIVE: A considerable amount of patients with somatoform disorders do not benefit from psychotherapy as much as expected. Our aim was to explore whether readiness to change moderates the relationship between the intensity of symptoms and therapy outcome in the early stages of psychotherapy. METHOD: 144 patients with somatoform disorders received an outpatient cognitive-behavioural intervention. Symptom intensity was measured with the Screening for Somatoform Disorders (SOMS-7)...
January 19, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28096356/active-mlkl-triggers-the-nlrp3-inflammasome-in-a-cell-intrinsic-manner
#3
Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Núñez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux, Kate E Lawlor, Lisa M Lindqvist, James E Vince
Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like protein (MLKL), which results in disruption of the plasma membrane. Necroptotic cell lysis, and resultant release of proinflammatory mediators, is thought to cause inflammation in necroptotic disease models. However, we previously showed that MLKL signaling can also promote inflammation by activating the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome to recruit the adaptor protein apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) and trigger caspase-1 processing of the proinflammatory cytokine IL-1β...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28089578/dual-influences-of-early-life-maternal-deprivation-on-histone-deacetylase-activity-and-recognition-memory-in-rats
#4
Manoel Osório Albuquerque Filho, Betânia Souza de Freitas, Rebeca Carvalho Lacerda Garcia, Pedro Castilhos de Freitas Crivelaro, Nadja Schröder, Maria Noêmia Martins de Lima
Exposure to stress early in life may negatively impact nervous system functioning, including increasing the proneness to learning and memory impairments later in life. Maternal deprivation, a model of early-life stress, hinders memory in adult rats and lessens brain-derived neurotrophic factor (BDNF) levels in the hippocampus in a very heterogeneous way among individuals. The main goal of the present study was to investigate the possible epigenetic modulation underlying recognition memory impairment and reduced BDNF levels in the hippocampus of adult maternally deprived rats...
January 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28076404/combined-inhibition-of-the-renin-angiotensin-system-and-neprilysin-positively-influences-complex-mitochondrial-adaptations-in-progressive-experimental-heart-failure
#5
Laura Grois, Julian Hupf, Jörg Reinders, Josef Schröder, Alexander Dietl, Peter M Schmid, Carsten Jungbauer, Markus Resch, Lars S Maier, Andreas Luchner, Christoph Birner
BACKGROUND: Inhibitors of the renin angiotensin system and neprilysin (RAS-/NEP-inhibitors) proved to be extraordinarily beneficial in systolic heart failure. Furthermore, compelling evidence exists that impaired mitochondrial pathways are causatively involved in progressive left ventricular (LV) dysfunction. Consequently, we aimed to assess whether RAS-/NEP-inhibition can attenuate mitochondrial adaptations in experimental heart failure (HF). METHODS AND RESULTS: By progressive right ventricular pacing, distinct HF stages were induced in 15 rabbits, and 6 animals served as controls (CTRL)...
2017: PloS One
https://www.readbyqxmd.com/read/28072527/rational-synthesis-and-investigation-of-porous-metal-organic-framework-materials-from-a-preorganized-heterometallic-carboxylate-building-block
#6
Aleksandr A Sapianik, Ekaterina N Zorina-Tikhonova, Mikhail A Kiskin, Denis G Samsonenko, Konstantin A Kovalenko, Alexey A Sidorov, Igor L Eremenko, Danil N Dybtsev, Alexander J Blake, Stephen P Argent, Martin Schröder, Vladimir P Fedin
The tetranuclear heterometallic complex [Li2Zn2(piv)6(py)2] (1, where piv(-) = pivalate and py = pyridine) has been successfully employed as a presynthesized node for the construction of four porous metal-organic frameworks (MOFs) [Li2Zn2(R-bdc)3(bpy)]·solv (2-R, R-bdc(2-); R = H, Br, NH2, NO2) by reaction with 4,4'-bipyridine (bpy) and terephthalate anionic linkers. The [Li2Zn2] node is retained in the products, representing a rare example of the rational step-by-step design of isoreticular MOFs based on complex heterometallic building units...
January 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28071687/bacterial-load-of-conditioned-pressure-ulcers-is-not-a-predictor-for-early-flap-failure-in-spinal-cord-injury
#7
T Kamradt, S Klein, S Zimmermann, J Schröder-Braunstein, C H Fürstenberg, C Hensel, N Weidner, A Hug
OBJECTIVES: Pressure ulcers impose a major lifetime medical problem to patients with high-grade spinal cord injury (SCI). For patients with stages 3-4 pressure ulcers, plastic surgery is often the only remaining treatment option. Despite considerable flap failure rates of around 30%, only sparse knowledge exists on predictors for flap failure. Hence, identification of predictors for flap failures is needed. METHODS: We prospectively enrolled 38 SCI patients with stages 3-4 pressure ulcers scheduled for plastic surgery...
January 10, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28066951/a-divalent-pentastable-redox-switchable-donor-acceptor-rotaxane
#8
Hendrik V Schröder, Henrik Hupatz, Andreas J Achazi, Sebastian Sobottka, Biprajit Sarkar, Beate Paulus, Christoph A Schalley
Donor-acceptor materials with small HOMO-LUMO gaps are important in molecular electronics, but often difficult to synthesise. A simple and efficient way to position tetrathiafulvalene (TTF) as the donor and naphthalene diamide (NDI) as the acceptor in close proximity to each other in a divalent crown/ammonium pseudo[2]rotaxane is presented. The divalent design provides high chelate cooperativity and much stronger binding compared to a monovalent analogue. The pseudo[2]rotaxane is then doubly interlocked by stoppering it in a catalyst-free 1,3-dipolar cycloaddition...
January 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28051893/shame-in-medical-education-a-randomized-study-of-the-acquisition-of-intimate-examination-skills-and-its-effect-on-subsequent-performance
#9
Wolf E Hautz, Therese Schröder, Katja A Dannenberg, Maren März, Henrike Hölzer, Olaf Ahlers, Anke Thomas
THEORY: Although medical students are exposed to a variety of emotions, the impact of emotions on learning has received little attention so far. Shame-provoking intimate examinations are among the most memorable events for students. Their emotions, however, are rarely addressed during training, potentially leading to withdrawal and avoidance and, consequently, performance deficits. However, emotions of negative valance such as shame may be particularly valuable for learning, as they might prompt mental rehearsal...
January 4, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28041633/back-to-the-basics-cnidarians-start-to-fire
#10
REVIEW
Thomas C G Bosch, Alexander Klimovich, Tomislav Domazet-Lošo, Stefan Gründer, Thomas W Holstein, Gáspár Jékely, David J Miller, Andrea P Murillo-Rincon, Fabian Rentzsch, Gemma S Richards, Katja Schröder, Ulrich Technau, Rafael Yuste
The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to reveal fundamental principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems...
December 29, 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/28038425/knock-out-of-the-nadph-oxidase-nox4-has-no-impact-on-life-span-in-mice
#11
Flavia Rezende, Christoph Schürmann, Susanne Schütz, Sabine Harenkamp, Eva Herrmann, Michael Seimetz, Norbert Weißmann, Katrin Schröder
The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals...
December 22, 2016: Redox Biology
https://www.readbyqxmd.com/read/28035718/thsd7a-expression-in-human-cancer
#12
Phillip R Stahl, Elion Hoxha, Thorsten Wiech, Cornelia Schröder, Ronald Simon, Rolf A K Stahl
We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20,000 tissue spots in more than 70 different tumor entities by immunohistochemistry using tissue microarrays. THSD7A expression was highly variable in different neoplasias with differing staining patterns. Both gain and loss of THSD7A expression compared to expression status in non-tumor tissue were linked to tumor-specific markers in the different tumor entities and were of prognostic value...
December 30, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28032227/development-of-a-standardized-curriculum-concept-for-continuing-training-in-hernia-surgery-german-hernia-school
#13
R Lorenz, B Stechemesser, W Reinpold, R Fortelny, F Mayer, W Schröder, F Köckerling
INTRODUCTION: The increasingly more complex nature of hernia surgery means that training programs for young surgeons must now meet ever more stringent requirements. There is a growing demand for improved structuring and standardization of education and training in hernia surgery. MATERIALS AND METHODS: In 2011, the concept of a Hernia School was developed in Germany and has been gradually implemented ever since. That concept comprises the following series of interrelated, tiered course elements: Hernie kompakt (Hernia compact), Hernie konkret (Hernia concrete), and Hernie complex (Hernia complex)...
December 28, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28024332/structure-and-growth-of-hexagonal-boron-nitride-on-ir-111
#14
Ferdinand H Farwick Zum Hagen, Domenik M Zimmermann, Caio C Silva, Christoph Schlueter, Nicolae Atodiresei, Wouter Jolie, Antonio J Martínez-Galera, Daniela Dombrowski, Ulrike A Schröder, Moritz Will, Predrag Lazić, Vasile Caciuc, Stefan Blügel, Tien-Lin Lee, Thomas Michely, Carsten Busse
Using the X-ray standing wave method, scanning tunneling microscopy, low energy electron diffraction, and density functional theory, we precisely determine the lateral and vertical structure of hexagonal boron nitride on Ir(111). The moiré superstructure leads to a periodic arrangement of strongly chemisorbed valleys in an otherwise rather flat, weakly physisorbed plane. The best commensurate approximation of the moiré unit cell is (12 × 12) boron nitride cells resting on (11 × 11) substrate cells, which is at variance with several earlier studies...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28017868/fabrication-of-amorphous-strontium-polyphosphate-microparticles-that-induce-mineralization-of-bone-cells-in-vitro-and-in-vivo
#15
Werner E G Müller, Emad Tolba, Maximilian Ackermann, Meik Neufurth, Shunfeng Wang, Qingling Feng, Heinz C Schröder, Xiaohong Wang
: Here we describe the fabrication process of amorphous strontium-polyphosphate microparticles ("Sr-a-polyP-MP"). The effects of these particles on growth and gene expression were investigated with SaOS-2 cells as well as with human mesenchymal stem cells (MSC) and compared with those particles prepared of amorphous calcium-polyphosphate ("Ca-a-polyP-MP") and of strontium salt. The results revealed a markedly higher stimulation of growth of MSC by "Sr-a-polyP-MP" compared to "Ca-a-polyP-MP" and a significant increase in mineralization of SaOS-2 cells, as well as an enhanced upregulation of the expression of the genes encoding for alkaline phosphatase and the bone morphogenetic protein 2 (BMP-2), likewise performed with SaOS-2 cells...
December 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28012779/vaccination-of-alpacas-against-rift-valley-fever-virus-safety-immunogenicity-and-pathogenicity-of-mp-12-vaccine
#16
M Rissmann, R Ulrich, C Schröder, B Hammerschmidt, D Hanke, C Mroz, M H Groschup, M Eiden
Rift Valley fever (RVF) is an emerging zoonosis of major public health concern in Africa and Arabia. Previous outbreaks attributed camelids a significant role in the epidemiology of Rift Valley fever virus (RVFV), making them an important target species for vaccination. Using three alpacas as model-organisms for dromedary camels, the safety, immunogenicity and pathogenicity of the MP-12 vaccine were evaluated in this study. To compare both acute and subacute effects, animals were euthanized at 3 and 31days post infection (dpi)...
December 21, 2016: Vaccine
https://www.readbyqxmd.com/read/28008429/applications-of-patient-specific-3d-printing-in-medicine
#17
Martin Heller, Heide-Katharina Bauer, Elisabeth Goetze, Matthias Gielisch, Klaus E Roth, Philipp Drees, Gerrit S Maier, Bernhard Dorweiler, Ahmed Ghazy, Meik Neufurth, Werner E G Müller, Heinz C Schröder, Xiaohong Wang, Christian-Friedrich Vahl, Bilal Al-Nawas
Already three decades ago, the potential of medical 3D printing (3DP) or rapid prototyping for improved patient treatment began to be recognized. Since then, more and more medical indications in different surgical disciplines have been improved by using this new technique. Numerous examples have demonstrated the enormous benefit of 3DP in the medical care of patients by, for example, planning complex surgical interventions preoperatively, reducing implantation steps and anesthesia times, and helping with intraoperative orientation...
2016: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28005152/incidence-of-sialolithiasis-in-denmark-a-nationwide-population-based-register-study
#18
Stine Attrup Schrøder, Mikael Andersson, Jan Wohlfahrt, Niels Wagner, Allan Bardow, Preben Homøe
Sialolithiasis is a frequent disorder affecting the salivary glands. The incidence rate (IR) has been reported to be 2.9-5.5 per 100,000 person-years, but all previous studies have been based on selected hospital data. In this study, we conducted a population-based study evaluating the IR of sialolithiasis and the IR variation according to age, gender and geography in Denmark. We included data from hospitals as well as from private ear, nose and throat (ENT) clinics. The study was based on registry data on all sialolithiasis cases in Denmark between 2003 and 2009 extracted from the Danish National Patient Registry (hospital cohort) and the Danish Regions Centre for Healthcare Statistics (private ENT clinic cohort)...
December 22, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28000975/hypointense-vessels-detected-by-susceptibility-weighted-imaging-identifies-tissue-at-risk-of-infarction-in-anterior-circulation-stroke
#19
Bastian Cheng, Nikolaus Schröder, Nils Daniel Forkert, Peter Ludewig, André Kemmling, Tim Magnus, Jens Fiehler, Christian Gerloff, Götz Thomalla
BACKGROUND AND PURPOSE: The diagnostic value of susceptibility-weighted magnetic resonance imaging of acute stroke patients has shown potential as a surrogate marker of impaired hemodynamics. We investigate the value of asymmetrical hypointense cerebral vessels (HV) for the identification of vessel status and tissue at risk of infarction (TaR). METHODS: Symmetry of HV was visually rated on SWI data from a well-defined population of acute anterior circulation stroke with onset <24 hours...
December 21, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27995359/associations-between-disorder-specific-symptoms-of-anxiety-and-error-monitoring-brain-activity-in-young-children
#20
Sharon L Lo, Hans S Schroder, Megan E Fisher, C Emily Durbin, Kate D Fitzgerald, Judith H Danovitch, Jason S Moser
Anxiety disorders are among the earliest emerging disorders and most common mental health problem across the lifespan. A common characteristic of individuals with anxiety is poor attentional and cognitive control. Therefore, researchers are interested in how cognitive functioning relates to anxiety in young children. In particular, research has demonstrated associations between anxiety and electrophysiological markers of cognitive control skills such as the error-related negativity (ERN). The nature of the anxiety-ERN relationship is not well understood, however...
December 19, 2016: Journal of Abnormal Child Psychology
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