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https://www.readbyqxmd.com/read/29454629/postoperative-pain-and-analgesia-administration-in-children-after-urological-outpatient-procedures
#1
A Schröder, F A Campbell, W A Farhat, J L Pippi Salle, D J Bägli, A J Lorenzo, M A Koyle
INTRODUCTION: There are limited data about pain patterns, analgesic requirements and factors predicting opioid requirements of children undergoing outpatient urologic surgery. This prospective study aimed to assess recovery profiles and pain medication requirements. METHODS: Patients between 6 months and 12 years of age were recruited prospectively between December 2013 and June 2014. Demographic and operative characteristics were collected. Following discharge home, the parents were asked to administer both acetaminophen and ibuprofen Q6H at a weight-adjusted dose, based on a schedule, until the end of postoperative day 2, and to administer the medication as required on postoperative day 3...
January 31, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29442492/homogeneous-coating-with-anion-exchange-ionomer-improves-the-cycling-stability-of-secondary-batteries-with-zinc-anode
#2
Daniel Stock, Saustin Dongmo, Felix Walther, Joachim Sann, Jürgen Janek, Daniel Schröder
Limited cycling stability of secondary cells with zinc anode arises mainly from the high solubility of oxidized zinc species in the alkaline electrolyte resulting in electrode shape change and loss of active material during repeated discharge and charge. We propose and successfully employ a homogeneous coating with an anion-exchange ionomer on model electrodes with electron-conductive host structure to confine the oxidized zinc species. Ideally, the confinement of oxidized zinc species reduces the shape change of the electrode and keeps the active material as close as possible at its place of origin...
February 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29432891/estimation-of-achievable-oxygen-consumption-following-transfusion-with-rejuvenated-red-blood-cells
#3
Amudan J Srinivasan, Kyle Kausch, Collin Inglut, Alan Gray, Matthew Landrigan, Jessica L Poisson, Jacob N Schroder, Ian J Welsby
OBJECTIVE: Erythrocyte storage induces a non-physiological increase in hemoglobin-oxygen affinity (quantified by low p50, the oxygen tension at 50% hemoglobin saturation), which can be restored through biochemical rejuvenation. The objective was to mathematically model the impact of transfusing up to three standard allogeneic units or rejuvenated units on oxygen delivery (DO 2 ) and oxygen consumption (VO 2 ). METHODS: Oxygen dissociation curves were generated from AS-1 RBC leukoreduced units (n = 7) before and after rejuvenation following manufacturer's instructions...
February 9, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29432466/knockdown-of-l1cam-significantly-reduces-metastasis-in-a-xenograft-model-of-human-melanoma-l1cam-is-a-potential-target-for-anti-melanoma-therapy
#4
Ann-Kathrin Ernst, Annika Putscher, Timur R Samatov, Anna Suling, Vladimir V Galatenko, Maxim Yu Shkurnikov, Evgeny N Knyazev, Alexander G Tonevitsky, Thomas Haalck, Tobias Lange, Hanna Maar, Jennifer Schröder-Schwarz, Kristoffer Riecken, Udo Schumacher, Daniel Wicklein
Finding additional functional targets for combination therapy could improve the outcome for melanoma patients. In a spontaneous metastasis xenograft model of human melanoma a shRNA mediated knockdown of L1CAM more than sevenfold reduced the number of lung metastases after the induction of subcutaneous tumors for two human melanoma cell lines (MeWo, MV3). Whole genome expression arrays of the initially L1CAM high MeWo subcutaneous tumors revealed unchanged or downregulated genes involved in epithelial to mesenchymal transition (EMT) except an upregulation of Jagged 1, indicating a compensatory change in Notch signaling especially as Jagged 1 expression showed an increase in MeWo L1CAM metastases and Jagged 1 was expressed in metastases of the initially L1CAM low MV3 cells as well...
2018: PloS One
https://www.readbyqxmd.com/read/29432122/caspase-1-self-cleavage-is-an-intrinsic-mechanism-to-terminate-inflammasome-activity
#5
Dave Boucher, Mercedes Monteleone, Rebecca C Coll, Kaiwen W Chen, Connie M Ross, Jessica L Teo, Guillermo A Gomez, Caroline L Holley, Damien Bierschenk, Katryn J Stacey, Alpha S Yap, Jelena S Bezbradica, Kate Schroder
Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown. Caspase-1 is activated on inflammasomes, signaling platforms that facilitate caspase-1 dimerization and autoprocessing. Previous studies with recombinant protein identified a caspase-1 tetramer composed of two p20 and two p10 subunits (p20/p10) as an active species. In this study, we report that in the cell, the dominant species of active caspase-1 dimers elicited by inflammasomes are in fact full-length p46 and a transient species, p33/p10...
February 6, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29417163/-profit-center-analysis-of-esophagectomy-economical-analysis-of-transthoracic-esophagectomy-depending-on-postoperative-complications
#6
C T Baltin, M Bludau, F Kron, T Zander, M Hallek, A H Hölscher, W Schröder
Due to increasing medical costs and yet limited financial resources, medical treatment and economic analyses can no longer be separated; therefore, direct costing and cost unit accounting become more and more relevant as controlling tools in hospital management. Transthoracic esophagectomy is an integral part of the current treatment concept in patients with esophageal carcinoma. The question of the present study was whether the present diagnosis-related groups (DRG) system is a cost-effective tool to represent transthoracic esophagectomy...
February 7, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29415017/gdna-extraction-yield-and-methylation-status-of-blood-samples-are-affected-by-long-term-storage-conditions
#7
Charlotte Schröder, Werner Steimer
Epigenetics is believed to provide great chances for a better understanding of the development and treatment of many diseases where the analysis of genomic DNA has so far failed to provide conclusive answers. Methylcytosine is a frequently used quantitative marker of epigenetic studies. Since immediate analysis of sampled material is in most cases not possible, storage time and conditions are critical aspects regarding the quality of genomic DNA and reliability of analysis. Blood is frequently used for such analyses...
2018: PloS One
https://www.readbyqxmd.com/read/29402815/introducing-a-virtual-lesion-model-of-dysphagia-resulting-from-pharyngeal-sensory-impairment
#8
Paul Muhle, Inga Claus, Thomas Marian, Jens B Schröder, Andreas Wollbrink, Christo Pantev, Tobias Warnecke, Rainer Dziewas, Sonja Suntrup-Krueger
BACKGROUND/AIMS: Performing neurophysiological and functional imaging studies in severely affected patients to investigate novel neurostimulation techniques for the treatment of neurogenic dysphagia is difficult. Therefore, basic research needs to be conducted in healthy subjects. Swallowing is a motor function highly dependent on sensory afferent input. Here we propose a virtual peripheral sensory lesion model to mimic pharyngeal sensory impairment, which is known as a major contributor to dysphagia in neurological disease...
January 25, 2018: Neuro-Signals
https://www.readbyqxmd.com/read/29400383/solvation-dynamics-in-polar-solvents-and-imidazolium-ionic-liquids-failure-of-linear-response-approximations
#9
Esther Heid, Christian Schröder
This study presents the large scale computer simulations of two common fluorophores, N-methyl-6-oxyquinolinium betaine and coumarin 153, in five polar or ionic solvents. The validity of linear response approximations to calculate the time-dependent Stokes shift is evaluated in each system. In most studied systems linear response theory fails. In ionic liquids the magnitude of the overall response is largely overestimated, and linear response theory is not able to capture the individual contributions of cations and anions...
February 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29397051/support-needs-of-caregivers-of-patients-with-amyotrophic-lateral-sclerosis-a-qualitative-study
#10
Jessica de Wit, Carin D Schröder, Julia El Mecky, Anita Beelen, Leonard H van den Berg, Johanna M A Visser-Meily
OBJECTIVE: The aim of this study was to explore the support needs of Dutch informal caregivers of patients with amyotrophic lateral sclerosis (ALS). METHOD: Individual semi-structured interviews were conducted with 21 caregivers of ALS patients. Audio-taped interviews were transcribed and data were analyzed thematically. Result A total of four global support needs emerged: "more personal time", "assistance in applying for resources", "counseling", and "peer contact"...
February 5, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29393223/mild-salt-sensitive-hypertension-in-genetically-determined-low-nephron-number-is-associated-with-chloride-but-not-sodium-retention
#11
Kerstin Benz, Julia Schlote, Christoph Daniel, Christoph Kopp, Anke Dahlmann, Agnes Schröder, Nada Cordasic, Bernd Klanke, Karl Hilgers, Jens Titze, Kerstin Amann
BACKGROUND/AIMS: One potential pathomechanism how low nephron number leads to hypertension in later life is altered salt handling. We therefore evaluated changes in electrolyte and water content in wildtype (wt) and GDNF+/- mice with a 30% reduction of nephron number. METHODS: 32 GDNF+/- and 36 wt mice were fed with low salt (LSD, 0.03%, normal drinking water) or high salt (HSD, 4%, 0.9% drinking water) diet for 4 weeks. Blood pressure was continuously measured by telemetry in a subgroup...
January 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29392309/sphingosine-kinase-2-modulates-retinal-neovascularization-in-the-mouse-model-of-oxygen-induced-retinopathy
#12
Jeanette Eresch, Martin Stumpf, Alexander Koch, Rajkumar Vutukuri, Nerea Ferreirós, Yannick Schreiber, Katrin Schröder, Kavi Devraj, Rüdiger Popp, Lars-Olof Hattenbach, Josef Pfeilschifter, Waltraud Pfeilschifter
Purpose: Neovascularization is a major cause of blindness in various ocular diseases. Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1, Sphk2), emerged as a key player in a multitude of cellular processes, including cell survival, proliferation, inflammation, migration, and angiogenesis. We investigated the role of Sphk2, S1P, and S1P receptors (S1PR) during retinal neovascularization using the oxygen-induced retinopathy mouse model (OIR). Methods: Sphk2 overexpressing (tgSphk2) and Sphk2 knockout (Sphk2-/-) mice were used in the OIR model, exposed to 75% O2 over 5 days from postnatal day (P)7 to 12 to initiate vessel regression...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29385104/amorphous-smart-and-bioinspired-polyphosphate-nano-microparticles-a-biomaterial-for-regeneration-and-repair-of-osteo-articular-impairments-in-situ
#13
Werner E G Müller, Meik Neufurth, Shunfeng Wang, Maximilian Ackermann, Rafael Muñoz-Espí, Qingling Feng, Qiang Lu, Heinz C Schröder, Xiaohong Wang
Using femur explants from mice as an in vitro model, we investigated the effect of the physiological polymer, inorganic polyphosphate (polyP), on differentiation of the cells of the bone marrow in their natural microenvironment into the osteogenic and chondrogenic lineages. In the form of amorphous Ca-polyP nano/microparticles, polyP retains its function to act as both an intra- and extracellular metabolic fuel and a stimulus eliciting morphogenetic signals. The method for synthesis of the nano/microparticles with the polyanionic polyP also allowed the fabrication of hybrid particles with the bisphosphonate zoledronic acid, a drug used in therapy of bone metastases in cancer patients...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29374603/novel-insights-into-mitochondrial-molecular-targets-of-iron-induced-neurodegeneration-reversal-by-cannabidiol
#14
Vanessa Kappel da Silva, Betânia Souza de Freitas, Victória Campos Dornelles, Luiza Wilges Kist, Maurício Reis Bogo, Milena Carvalho Silva, Emílio Luiz Streck, Jaime Eduardo Hallak, Antônio Waldo Zuardi, José Alexandre S Crippa, Nadja Schröder
Evidence has demonstrated iron accumulation in specific brain regions of patients suffering from neurodegenerative disorders, and this metal has been recognized as a contributing factor for neurodegeneration. Using an experimental model of brain iron accumulation, we have shown that iron induces severe memory deficits that are accompanied by oxidative stress, increased apoptotic markers, and decreased synaptophysin in the hippocampus of rats. The present study aims to characterize iron loading effects as well as to determine the molecular targets of cannabidiol (CBD), the main non-psychomimetic compound of Cannabis sativa, on mitochondria...
January 25, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29371402/molecular-imaging-in-cancer-drug-development
#15
Stijn J H Waaijer, Iris C Kok, Bertha Eisses, Carolien P Schröder, Mathilde Jalving, Adrienne H Brouwers, Marjolijn N Lub-de Hooge, Elisabeth G E de Vries
Developing new oncology drugs has increased since the improved understanding of cancer's complex biology. The oncology field has become the top therapeutic research area for new drugs. However, only a limited number of drugs entering clinical trials will be approved for use as standard of care for cancer patients. Molecular imaging is increasingly perceived as a tool to support go/no-go decisions early during drug development. It encompasses a wide range of techniques including radiolabeling a compound of interest followed by visualization with single photon emission computed tomography or positron emission tomography...
January 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29347337/controlling-percolation-with-limited-resources
#16
Malte Schröder, Nuno A M Araújo, Didier Sornette, Jan Nagler
Connectivity, or the lack thereof, is crucial for the function of many man-made systems, from financial and economic networks over epidemic spreading in social networks to technical infrastructure. Often, connections are deliberately established or removed to induce, maintain, or destroy global connectivity. Thus, there has been a great interest in understanding how to control percolation, the transition to large-scale connectivity. Previous work, however, studied control strategies assuming unlimited resources...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29339747/an-orthotopic-mouse-model-of-gastric-cancer-invasion-and-metastasis
#17
Rita A Busuttil, David S Liu, Natasha Di Costanzo, Jan Schröder, Catherine Mitchell, Alex Boussioutas
Gastric cancer is a leading cause of cancer death worldwide, with advanced stage being correlated to the level of tumour invasion and metastasis. Current research is heavily focused on the identification and development of efficacious therapeutics targeting these fundamental hallmarks of cancer, however there are currently no animal models that mimic the invasive phenotypes observed in humans. To address this we have developed an orthotopic mouse model whereby gastric cancer cell lines are tagged with luciferase and injected into the subserosal layer of the stomach...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337051/fermt2-links-cortical-actin-structures-plasma-membrane-tension-and-focal-adhesion-function-to-stabilize-podocyte-morphology
#18
M Yasuda-Yamahara, M Rogg, J Frimmel, P Trachte, M Helmstaedter, P Schroder, M Schiffer, C Schell, T B Huber
Simplification and retraction of podocyte protrusions, generally termed as foot process effacement, is a uniform pathological pattern observed in the majority of glomerular disease, including focal segmental glomerulosclerosis. However, it is still incompletely understood how the interaction of cortical actin structures, actomyosin contractility and focal adhesions, is being orchestrated to control foot process morphology in health and disease. By uncovering the functional role of fermitin family member 2 (FERMT2 or kindlin-2) in podocytes, we provide now evidence, how cell-extracellular matrix (ECM) interactions modulate membrane tension and actomyosin contractility...
January 11, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29334686/fat-mass-and-obesity-related-gene-variants-rs9939609-and-rs7185735-are-associated-with-second-generation-antipsychotic-induced-weight-gain
#19
Charlotte Schröder, Fabian Czerwensky, Stefan Leucht, Werner Steimer
INTRODUCTION: Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy. METHODS: We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were included in a naturalistic study. RESULTS: After 4 weeks of treatment, we did not observe any significant association of polymorphisms with weight change in the whole study population (p>0...
January 15, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29333720/degree-of-sglt1-phosphorylation-is-associated-with-but-does-not-determine-segment-specific-glucose-transport-features-in-the-porcine-small-intestines
#20
Stefanie Klinger, Patrick Lange, Elisabeth Brandt, Karin Hustedt, Bernd Schröder, Gerhard Breves, Jens Herrmann
Glucose-induced electrogenic ion transport is higher in the porcine ileum compared with the jejunum despite equal apical abundance of SGLT1. The objective of this study was a detailed determination of SGLT1 and GLUT2 expressions at mRNA and protein levels along the porcine small intestinal axis. Phosphorylation of SGLT1 at serine 418 was assessed as a potential modulator of activity. Porcine intestinal tissues taken along the intestinal axis 1 h or 3 h after feeding were analyzed for relative mRNA (RT-PCR) and protein levels (immunoblot) of SGLT1, pSGLT1, GLUT2, (p)AMPK, β2 -receptor, and PKA substrates...
January 2018: Physiological Reports
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