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https://www.readbyqxmd.com/read/27471010/translational-profiling-of-retinal-ganglion-cell-optic-nerve-regeneration-in-xenopus-laevis
#1
G B Whitworth, B C Misaghi, D M Rosenthal, E A Mills, D J Heinen, A H Watson, C W Ives, S H Ali, K Bezold, N Marsh-Armstrong, F L Watson
Unlike adult mammals, adult frogs regrow their optic nerve following a crush injury, making Xenopus laevis a compelling model for studying the molecular mechanisms that underlie neuronal regeneration. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate ribosome-associated mRNAs from a target cell population, we have generated a transcriptional profile by RNA-Seq for retinal ganglion cells (RGC) during the period of recovery following an optic nerve injury. Based on bioinformatic analysis using the Xenopus laevis 9...
July 25, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27267887/strategies-in-primary-healthcare-to-implement-early-identification-of-risky-alcohol-consumption-why-do-they-work-or-not-a-qualitative-evaluation-of-the-odhin-study
#2
M Keurhorst, M Heinen, J Colom, C Linderoth, U Müssener, K Okulicz-Kozaryn, J Palacio-Vieira, L Segura, F Silfversparre, L Słodownik, E Sorribes, M Laurant, M Wensing
BACKGROUND: Screening and brief interventions (SBI) in primary healthcare are cost-effective in risky drinkers, yet they are not offered to all eligible patients. This qualitative study aimed to provide more insight into the factors and mechanisms of why, how, for whom and under what circumstances implementation strategies work or do not work in increasing SBI. METHODS: Semi-structured interviews were conducted between February and July 2014 with 40 GPs and 28 nurses in Catalonia, the Netherlands, Poland, and Sweden...
June 7, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/26840047/igsf1-deficiency-lessons-from-an-extensive-case-series-and-recommendations-for-clinical-management
#3
S D Joustra, C A Heinen, N Schoenmakers, M Bonomi, B E P B Ballieux, M-O Turgeon, D J Bernard, E Fliers, A S P van Trotsenburg, M Losekoot, L Persani, J M Wit, N R Biermasz, A M Pereira, W Oostdijk
Clinical and biochemical characteristics of 69 male patients and 56 female IGSF1 mutation carriers were collected, providing recommendations for mutational analysis, endocrine work-up, and long-term care.
April 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26824124/health-promotion-contrarians-luther-terry-halbert-l-dunn-robert-f-allen-and-edward-m-kennedy
#4
Marc Manley, Donald B Ardell, Judd R Allen, LuAnn Heinen
No abstract text is available yet for this article.
November 2015: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/26371681/classical-liquids-in-fractal-dimension
#5
Marco Heinen, Simon K Schnyder, John F Brady, Hartmut Löwen
We introduce fractal liquids by generalizing classical liquids of integer dimensions d=1,2,3 to a noninteger dimension dl. The particles composing the liquid are fractal objects and their configuration space is also fractal, with the same dimension. Realizations of our generic model system include microphase separated binary liquids in porous media, and highly branched liquid droplets confined to a fractal polymer backbone in a gel. Here, we study the thermodynamics and pair correlations of fractal liquids by computer simulation and semianalytical statistical mechanics...
August 28, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/26277734/severity-of-polymicrobial-sepsis-modulates-mitochondrial-function-in-rat-liver
#6
A Herminghaus, F Barthel, A Heinen, C Beck, C Vollmer, I Bauer, A Weidinger, A V Kozlov, O Picker
Mitochondrial dysfunction is assumed to be an important contributor to multi organ dysfunction syndrome. Here, the effects of varying degrees of sepsis on hepatic mitochondrial function were investigated. Moderate or more severe sepsis was induced in rats using a colon ascendens stent peritonitis (CASP)-model (16 G and 14 G stent respectively). Respiratory control ratio (RCR) was significantly higher in the 16 G-group and unchanged in the 14 G-group compared with healthy controls. The ADP/O ratio was similar in all groups...
September 2015: Mitochondrion
https://www.readbyqxmd.com/read/26214711/transgenic-wheat-expressing-a-barley-udp-glucosyltransferase-detoxifies-deoxynivalenol-and-provides-high-levels-of-resistance-to-fusarium-graminearum
#7
Xin Li, Sanghyun Shin, Shane Heinen, Ruth Dill-Macky, Franz Berthiller, Natalya Nersesian, Thomas Clemente, Susan McCormick, Gary J Muehlbauer
Fusarium head blight (FHB), mainly caused by Fusarium graminearum, is a devastating disease of wheat that results in economic losses worldwide. During infection, F. graminearum produces trichothecene mycotoxins, including deoxynivalenol (DON), that increase fungal virulence and reduce grain quality. Transgenic wheat expressing a barley UDP-glucosyltransferase (HvUGT13248) were developed and evaluated for FHB resistance, DON accumulation, and the ability to metabolize DON to the less toxic DON-3-O-glucoside (D3G)...
November 2015: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/25995705/development-of-a-general-analysis-and-unfolding-scheme-and-its-application-to-measure-the-energy-spectrum-of-atmospheric-neutrinos-with-icecube-icecube-collaboration
#8
M G Aartsen, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, T Anderson, C Arguelles, T C Arlen, J Auffenberg, X Bai, S W Barwick, V Baum, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, M Bissok, E Blaufuss, J Blumenthal, D J Boersma, C Bohm, F Bos, D Bose, S Böser, O Botner, L Brayeur, H P Bretz, A M Brown, J Casey, M Casier, E Cheung, D Chirkin, A Christov, B Christy, K Clark, L Classen, F Clevermann, S Coenders, D F Cowen, A H Cruz Silva, M Danninger, J Daughhetee, J C Davis, M Day, J P A M de André, C De Clercq, S De Ridder, P Desiati, K D de Vries, M de With, T DeYoung, J C Díaz-Vélez, M Dunkman, R Eagan, B Eberhardt, B Eichmann, J Eisch, S Euler, P A Evenson, O Fadiran, A R Fazely, A Fedynitch, J Feintzeig, J Felde, T Feusels, K Filimonov, C Finley, T Fischer-Wasels, S Flis, A Franckowiak, K Frantzen, T Fuchs, T K Gaisser, R Gaior, J Gallagher, L Gerhardt, D Gier, L Gladstone, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, J A Goodman, D Góra, D Grant, P Gretskov, J C Groh, A Groß, C Ha, C Haack, A Haj Ismail, P Hallen, A Hallgren, F Halzen, K Hanson, D Hebecker, D Heereman, D Heinen, K Helbing, R Hellauer, D Hellwig, S Hickford, G C Hill, K D Hoffman, R Hoffmann, A Homeier, K Hoshina, F Huang, W Huelsnitz, P O Hulth, K Hultqvist, S Hussain, A Ishihara, E Jacobi, J Jacobsen, K Jagielski, G S Japaridze, K Jero, O Jlelati, M Jurkovic, B Kaminsky, A Kappes, T Karg, A Karle, M Kauer, A Keivani, J L Kelley, A Kheirandish, J Kiryluk, J Kläs, S R Klein, J H Köhne, G Kohnen, H Kolanoski, A Koob, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, A Kriesten, K Krings, G Kroll, M Kroll, J Kunnen, N Kurahashi, T Kuwabara, M Labare, D T Larsen, M J Larson, M Lesiak-Bzdak, M Leuermann, J Leute, J Lünemann, J Madsen, G Maggi, R Maruyama, K Mase, H S Matis, R Maunu, F McNally, K Meagher, M Medici, A Meli, T Meures, S Miarecki, E Middell, E Middlemas, N Milke, J Miller, L Mohrmann, T Montaruli, R Morse, R Nahnhauer, U Naumann, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke, S Odrowski, A Olivas, A Omairat, A O'Murchadha, T Palczewski, L Paul, Ö Penek, J A Pepper, C Pérez de Los Heros, C Pfendner, D Pieloth, E Pinat, J Posselt, P B Price, G T Przybylski, J Pütz, M Quinnan, L Rädel, M Rameez, K Rawlins, P Redl, I Rees, R Reimann, M Relich, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, J P Rodrigues, M Rongen, C Rott, T Ruhe, B Ruzybayev, D Ryckbosch, S M Saba, H-G Sander, J Sandroos, M Santander, S Sarkar, K Schatto, F Scheriau, T Schmidt, M Schmitz, S Schoenen, S Schöneberg, A Schönwald, A Schukraft, L Schulte, O Schulz, D Seckel, Y Sestayo, S Seunarine, R Shanidze, M W E Smith, D Soldin, G M Spiczak, C Spiering, M Stamatikos, T Stanev, N A Stanisha, A Stasik, T Stezelberger, R G Stokstad, A Stößl, E A Strahler, R Ström, N L Strotjohann, G W Sullivan, H Taavola, I Taboada, A Tamburro, A Tepe, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, D Tosi, M Tselengidou, E Unger, M Usner, S Vallecorsa, N van Eijndhoven, J Vandenbroucke, J van Santen, M Vehring, M Voge, M Vraeghe, C Walck, M Wallraff, Ch Weaver, M Wellons, C Wendt, S Westerhoff, B J Whelan, N Whitehorn, C Wichary, K Wiebe, C H Wiebusch, D R Williams, H Wissing, M Wolf, T R Wood, K Woschnagg, D L Xu, X W Xu, J P Yanez, G Yodh, S Yoshida, P Zarzhitsky, J Ziemann, S Zierke, M Zoll, K Morik
We present the development and application of a generic analysis scheme for the measurement of neutrino spectra with the IceCube detector. This scheme is based on regularized unfolding, preceded by an event selection which uses a Minimum Redundancy Maximum Relevance algorithm to select the relevant variables and a random forest for the classification of events. The analysis has been developed using IceCube data from the 59-string configuration of the detector. 27,771 neutrino candidates were detected in 346 days of livetime...
2015: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/25978221/flavor-ratio-of-astrophysical-neutrinos-above-35%C3%A2-tev-in-icecube
#9
M G Aartsen, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, T Anderson, C Arguelles, T C Arlen, J Auffenberg, X Bai, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, M Bissok, E Blaufuss, J Blumenthal, D J Boersma, C Bohm, F Bos, D Bose, S Böser, O Botner, L Brayeur, H-P Bretz, A M Brown, N Buzinsky, J Casey, M Casier, E Cheung, D Chirkin, A Christov, B Christy, K Clark, L Classen, F Clevermann, S Coenders, D F Cowen, A H Cruz Silva, J Daughhetee, J C Davis, M Day, J P A M de André, C De Clercq, H Dembinski, S De Ridder, P Desiati, K D de Vries, M de With, T DeYoung, J C Díaz-Vélez, J P Dumm, M Dunkman, R Eagan, B Eberhardt, T Ehrhardt, B Eichmann, J Eisch, S Euler, P A Evenson, O Fadiran, A R Fazely, A Fedynitch, J Feintzeig, J Felde, K Filimonov, C Finley, T Fischer-Wasels, S Flis, K Frantzen, T Fuchs, T K Gaisser, R Gaior, J Gallagher, L Gerhardt, D Gier, L Gladstone, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, J A Goodman, D Góra, D Grant, P Gretskov, J C Groh, A Groß, C Ha, C Haack, A Haj Ismail, P Hallen, A Hallgren, F Halzen, K Hanson, D Hebecker, D Heereman, D Heinen, K Helbing, R Hellauer, D Hellwig, S Hickford, G C Hill, K D Hoffman, R Hoffmann, A Homeier, K Hoshina, F Huang, W Huelsnitz, P O Hulth, K Hultqvist, A Ishihara, E Jacobi, J Jacobsen, G S Japaridze, K Jero, M Jurkovic, B Kaminsky, A Kappes, T Karg, A Karle, M Kauer, A Keivani, J L Kelley, A Kheirandish, J Kiryluk, J Kläs, S R Klein, J-H Köhne, G Kohnen, H Kolanoski, A Koob, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, A Kriesten, K Krings, G Kroll, M Kroll, J Kunnen, N Kurahashi, T Kuwabara, M Labare, J L Lanfranchi, D T Larsen, M J Larson, M Lesiak-Bzdak, M Leuermann, J Lünemann, J Madsen, G Maggi, R Maruyama, K Mase, H S Matis, R Maunu, F McNally, K Meagher, M Medici, A Meli, T Meures, S Miarecki, E Middell, E Middlemas, N Milke, J Miller, L Mohrmann, T Montaruli, R Morse, R Nahnhauer, U Naumann, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke, A Olivas, A Omairat, A O'Murchadha, T Palczewski, L Paul, Ö Penek, J A Pepper, C Pérez de los Heros, C Pfendner, D Pieloth, E Pinat, J Posselt, P B Price, G T Przybylski, J Pütz, M Quinnan, L Rädel, M Rameez, K Rawlins, P Redl, I Rees, R Reimann, M Relich, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, J P Rodrigues, M Rongen, C Rott, T Ruhe, B Ruzybayev, D Ryckbosch, S M Saba, H-G Sander, J Sandroos, M Santander, S Sarkar, K Schatto, F Scheriau, T Schmidt, M Schmitz, S Schoenen, S Schöneberg, A Schönwald, A Schukraft, L Schulte, O Schulz, D Seckel, Y Sestayo, S Seunarine, R Shanidze, M W E Smith, D Soldin, G M Spiczak, C Spiering, M Stamatikos, T Stanev, N A Stanisha, A Stasik, T Stezelberger, R G Stokstad, A Stößl, E A Strahler, R Ström, N L Strotjohann, G W Sullivan, H Taavola, I Taboada, A Tamburro, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, D Tosi, M Tselengidou, E Unger, M Usner, S Vallecorsa, N van Eijndhoven, J Vandenbroucke, J van Santen, S Vanheule, M Vehring, M Voge, M Vraeghe, C Walck, M Wallraff, Ch Weaver, M Wellons, C Wendt, S Westerhoff, B J Whelan, N Whitehorn, C Wichary, K Wiebe, C H Wiebusch, D R Williams, H Wissing, M Wolf, T R Wood, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, P Zarzhitsky, J Ziemann, M Zoll
A diffuse flux of astrophysical neutrinos above 100 TeV has been observed at the IceCube Neutrino Observatory. Here we extend this analysis to probe the astrophysical flux down to 35 TeV and analyze its flavor composition by classifying events as showers or tracks. Taking advantage of lower atmospheric backgrounds for showerlike events, we obtain a shower-biased sample containing 129 showers and 8 tracks collected in three years from 2010 to 2013. We demonstrate consistency with the (fe:fμ:fτ)⊕≈(1:1:1)⊕ flavor ratio at Earth commonly expected from the averaged oscillations of neutrinos produced by pion decay in distant astrophysical sources...
May 1, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/25751680/-indications-and-concept-of-follow-up-care-of-home-monitoring-for-premature-and-risk-infants
#10
K M Förster, S Immler, M Ensslen, A Flemmer, A Schulze, M von Poblotzki, O Genzel-Boroviczény, F Heinen, A Hilgendorff
The pros and cons of home monitoring especially for premature infants with continuing apneic episodes and/or chronic lung disease are an ongoing discussion. The controversy spans socio-economic requirements, medical indication as well as patient and family needs. Here, the costs of home monitoring and follow-up care on the one hand and longer hospitalization times on the other need to be considered. This article aims to create a basis for this discussion by summarizing current evidence for the indications and considerations for differential diagnoses while also outlining the established follow-up program for these patients at the Dr...
March 2015: Klinische Pädiatrie
https://www.readbyqxmd.com/read/25681941/short-time-diffusion-in-concentrated-bidisperse-hard-sphere-suspensions
#11
Mu Wang, Marco Heinen, John F Brady
Diffusion in bidisperse Brownian hard-sphere suspensions is studied by Stokesian Dynamics (SD) computer simulations and a semi-analytical theoretical scheme for colloidal short-time dynamics, based on Beenakker and Mazur's method [Physica A 120, 388-410 (1983); 126, 349-370 (1984)]. Two species of hard spheres are suspended in an overdamped viscous solvent that mediates the salient hydrodynamic interactions among all particles. In a comprehensive parameter scan that covers various packing fractions and suspension compositions, we employ numerically accurate SD simulations to compute the initial diffusive relaxation of density modulations at the Brownian time scale, quantified by the partial hydrodynamic functions...
February 14, 2015: Journal of Chemical Physics
https://www.readbyqxmd.com/read/25596902/alterations-in-the-trapezius-muscle-in-young-patients-with-migraine-a-pilot-case-series-with-mri
#12
M N Landgraf, B Ertl-Wagner, I K Koerte, J Thienel, T Langhagen, A Straube, R von Kries, P Reilich, A Pomschar, F Heinen
BACKGROUND/PURPOSE: Migraine is frequent in young adults and adolescents and often associated with neck muscle tension and pain. Common pathophysiological pathways, such as reciprocal cervico-trigeminal activation, are assumed. Tense areas within the neck muscles can be clinically observed many patients with migraine. The aim of this pilot case study was to visualize these tense areas via magnet resonance imaging (MRI). METHODS: Three young patients with migraine were examined by an experienced investigator...
May 2015: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/25519769/which-frail-older-patients-use-online-health-communities-and-why-a-mixed-methods-process-evaluation-of-use-of-the-health-and-welfare-portal
#13
Peter Makai, Marieke Perry, Sarah H M Robben, Henk Schers, Maud Heinen, Marcel G M Olde Rikkert, René J F Melis
BACKGROUND: Frail older people often receive fragmented care from multiple providers. According to the literature, there is an urgent need for coordination of care. Online and eHealth tools are increasingly used to improve coordination. However, there are significant barriers to their implementation in frail older people. OBJECTIVE: Our aim was to (1) evaluate differences in use of a personal online health community (POHC) for frail older people in relation to personal characteristics, and (2) explore barriers and facilitators for use as experienced by older people and their informal caregivers, using the case of the Health and Welfare Information Portal (ZWIP)...
2014: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/25244562/headache-cessation-by-an-educational-intervention-in-grammar-schools-a-cluster-randomized-trial
#14
RANDOMIZED CONTROLLED TRIAL
L Albers, F Heinen, M Landgraf, A Straube, B Blum, F Filippopulos, S Lehmann, U Mansmann, U Berger, Y Akboga, R von Kries
BACKGROUND AND PURPOSE: Headache is a common health problem in adolescents. There are a number of risk factors for headache in adolescents that are amenable to intervention. The aim of the study was to assess the effectiveness of a low-level headache prevention programme in the classroom setting to prevent these risk factors. METHODS: In all, 1674 students in 8th-10th grade at 12 grammar schools in greater Munich, Germany, were cluster randomized into intervention and control groups...
February 2015: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/25238345/observation-of-high-energy-astrophysical-neutrinos-in-three-years-of-icecube-data
#15
M G Aartsen, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, T Anderson, C Arguelles, T C Arlen, J Auffenberg, X Bai, S W Barwick, V Baum, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, M Bissok, E Blaufuss, J Blumenthal, D J Boersma, C Bohm, D Bose, S Böser, O Botner, L Brayeur, H-P Bretz, A M Brown, J Casey, M Casier, D Chirkin, A Christov, B Christy, K Clark, L Classen, F Clevermann, S Coenders, D F Cowen, A H Cruz Silva, M Danninger, J Daughhetee, J C Davis, M Day, J P A M de André, C De Clercq, S De Ridder, P Desiati, K D de Vries, M de With, T DeYoung, J C Díaz-Vélez, M Dunkman, R Eagan, B Eberhardt, B Eichmann, J Eisch, S Euler, P A Evenson, O Fadiran, A R Fazely, A Fedynitch, J Feintzeig, J Felde, T Feusels, K Filimonov, C Finley, T Fischer-Wasels, S Flis, A Franckowiak, K Frantzen, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, D Gier, L Gladstone, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, J A Goodman, D Góra, D T Grandmont, D Grant, P Gretskov, J C Groh, A Groß, C Ha, C Haack, A Haj Ismail, P Hallen, A Hallgren, F Halzen, K Hanson, D Hebecker, D Heereman, D Heinen, K Helbing, R Hellauer, D Hellwig, S Hickford, G C Hill, K D Hoffman, R Hoffmann, A Homeier, K Hoshina, F Huang, W Huelsnitz, P O Hulth, K Hultqvist, S Hussain, A Ishihara, E Jacobi, J Jacobsen, K Jagielski, G S Japaridze, K Jero, O Jlelati, M Jurkovic, B Kaminsky, A Kappes, T Karg, A Karle, M Kauer, J L Kelley, A Kheirandish, J Kiryluk, J Kläs, S R Klein, J-H Köhne, G Kohnen, H Kolanoski, A Koob, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, A Kriesten, K Krings, G Kroll, J Kunnen, N Kurahashi, T Kuwabara, M Labare, D T Larsen, M J Larson, M Lesiak-Bzdak, M Leuermann, J Leute, J Lünemann, O Macías, J Madsen, G Maggi, R Maruyama, K Mase, H S Matis, F McNally, K Meagher, A Meli, T Meures, S Miarecki, E Middell, E Middlemas, N Milke, J Miller, L Mohrmann, T Montaruli, R Morse, R Nahnhauer, U Naumann, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke, S Odrowski, A Olivas, A Omairat, A O'Murchadha, T Palczewski, L Paul, O Penek, J A Pepper, C Pérez de Los Heros, C Pfendner, D Pieloth, E Pinat, J Posselt, P B Price, G T Przybylski, J Pütz, M Quinnan, L Rädel, M Rameez, K Rawlins, P Redl, I Rees, R Reimann, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, J P Rodrigues, M Rongen, C Rott, T Ruhe, B Ruzybayev, D Ryckbosch, S M Saba, H-G Sander, M Santander, S Sarkar, K Schatto, F Scheriau, T Schmidt, M Schmitz, S Schoenen, S Schöneberg, A Schönwald, A Schukraft, L Schulte, O Schulz, D Seckel, Y Sestayo, S Seunarine, R Shanidze, C Sheremata, M W E Smith, D Soldin, G M Spiczak, C Spiering, M Stamatikos, T Stanev, N A Stanisha, A Stasik, T Stezelberger, R G Stokstad, A Stößl, E A Strahler, R Ström, N L Strotjohann, G W Sullivan, H Taavola, I Taboada, A Tamburro, A Tepe, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, D Tosi, M Tselengidou, E Unger, M Usner, S Vallecorsa, N van Eijndhoven, J Vandenbroucke, J van Santen, M Vehring, M Voge, M Vraeghe, C Walck, M Wallraff, Ch Weaver, M Wellons, C Wendt, S Westerhoff, B J Whelan, N Whitehorn, C Wichary, K Wiebe, C H Wiebusch, D R Williams, H Wissing, M Wolf, T R Wood, K Woschnagg, D L Xu, X W Xu, J P Yanez, G Yodh, S Yoshida, P Zarzhitsky, J Ziemann, S Zierke, M Zoll
A search for high-energy neutrinos interacting within the IceCube detector between 2010 and 2012 provided the first evidence for a high-energy neutrino flux of extraterrestrial origin. Results from an analysis using the same methods with a third year (2012-2013) of data from the complete IceCube detector are consistent with the previously reported astrophysical flux in the 100 TeV-PeV range at the level of 10(-8)  GeV cm-2 s-1 sr-1 per flavor and reject a purely atmospheric explanation for the combined three-year data at 5...
September 5, 2014: Physical Review Letters
https://www.readbyqxmd.com/read/25208922/a-disease-specific-metabolic-brain-network-associated-with-corticobasal-degeneration
#16
MULTICENTER STUDY
Martin Niethammer, Chris C Tang, Andrew Feigin, Patricia J Allen, Lisette Heinen, Sabine Hellwig, Florian Amtage, Era Hanspal, Jean Paul Vonsattel, Kathleen L Poston, Philipp T Meyer, Klaus L Leenders, David Eidelberg
Corticobasal degeneration is an uncommon parkinsonian variant condition that is diagnosed mainly on clinical examination. To facilitate the differential diagnosis of this disorder, we used metabolic brain imaging to characterize a specific network that can be used to discriminate corticobasal degeneration from other atypical parkinsonian syndromes. Ten non-demented patients (eight females/two males; age 73.9 ± 5.7 years) underwent metabolic brain imaging with (18)F-fluorodeoxyglucose positron emission tomography for atypical parkinsonism...
November 2014: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/25167245/measurement-of-the-atmospheric-%C3%AE-e-flux-in-icecube
#17
M G Aartsen, R Abbasi, Y Abdou, M Ackermann, J Adams, J A Aguilar, M Ahlers, D Altmann, J Auffenberg, X Bai, M Baker, S W Barwick, V Baum, R Bay, K Beattie, J J Beatty, S Bechet, J Becker Tjus, K-H Becker, M Bell, M L Benabderrahmane, S BenZvi, J Berdermann, P Berghaus, D Berley, E Bernardini, A Bernhard, D Bertrand, D Z Besson, D Bindig, M Bissok, E Blaufuss, J Blumenthal, D J Boersma, S Bohaichuk, C Bohm, D Bose, S Böser, O Botner, L Brayeur, A M Brown, R Bruijn, J Brunner, S Buitink, M Carson, J Casey, M Casier, D Chirkin, B Christy, K Clark, F Clevermann, S Cohen, D F Cowen, A H Cruz Silva, M Danninger, J Daughhetee, J C Davis, C De Clercq, S De Ridder, P Desiati, G de Vries-Uiterweerd, M de With, T DeYoung, J C Díaz-Vélez, J Dreyer, M Dunkman, R Eagan, B Eberhardt, J Eisch, R W Ellsworth, O Engdegård, S Euler, P A Evenson, O Fadiran, A R Fazely, A Fedynitch, J Feintzeig, T Feusels, K Filimonov, C Finley, T Fischer-Wasels, S Flis, A Franckowiak, R Franke, K Frantzen, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, L Gladstone, T Glüsenkamp, A Goldschmidt, G Golup, J A Goodman, D Góra, D Grant, A Groß, M Gurtner, C Ha, A Haj Ismail, A Hallgren, F Halzen, K Hanson, D Heereman, P Heimann, D Heinen, K Helbing, R Hellauer, S Hickford, G C Hill, K D Hoffman, R Hoffmann, A Homeier, K Hoshina, W Huelsnitz, P O Hulth, K Hultqvist, S Hussain, A Ishihara, E Jacobi, J Jacobsen, G S Japaridze, K Jero, O Jlelati, B Kaminsky, A Kappes, T Karg, A Karle, J L Kelley, J Kiryluk, F Kislat, J Kläs, S R Klein, J-H Köhne, G Kohnen, H Kolanoski, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, M Krasberg, G Kroll, J Kunnen, N Kurahashi, T Kuwabara, M Labare, H Landsman, M J Larson, M Lesiak-Bzdak, J Leute, J Lünemann, J Madsen, R Maruyama, K Mase, H S Matis, F McNally, K Meagher, M Merck, P Mészáros, T Meures, S Miarecki, E Middell, N Milke, J Miller, L Mohrmann, T Montaruli, R Morse, R Nahnhauer, U Naumann, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke, S Odrowski, A Olivas, M Olivo, A O'Murchadha, S Panknin, L Paul, J A Pepper, C Pérez de los Heros, C Pfendner, D Pieloth, N Pirk, J Posselt, P B Price, G T Przybylski, L Rädel, K Rawlins, P Redl, E Resconi, W Rhode, M Ribordy, M Richman, B Riedel, J P Rodrigues, C Rott, T Ruhe, B Ruzybayev, D Ryckbosch, S M Saba, T Salameh, H-G Sander, M Santander, S Sarkar, K Schatto, M Scheel, F Scheriau, T Schmidt, M Schmitz, S Schoenen, S Schöneberg, L Schönherr, A Schönwald, A Schukraft, L Schulte, O Schulz, D Seckel, S H Seo, Y Sestayo, S Seunarine, C Sheremata, M W E Smith, M Soiron, D Soldin, G M Spiczak, C Spiering, M Stamatikos, T Stanev, A Stasik, T Stezelberger, R G Stokstad, A Stößl, E A Strahler, R Ström, G W Sullivan, H Taavola, I Taboada, A Tamburro, S Ter-Antonyan, S Tilav, P A Toale, S Toscano, M Usner, D van der Drift, N van Eijndhoven, A Van Overloop, J van Santen, M Vehring, M Voge, M Vraeghe, C Walck, T Waldenmaier, M Wallraff, R Wasserman, Ch Weaver, M Wellons, C Wendt, S Westerhoff, N Whitehorn, K Wiebe, C H Wiebusch, D R Williams, H Wissing, M Wolf, T R Wood, K Woschnagg, C Xu, D L Xu, X W Xu, J P Yanez, G Yodh, S Yoshida, P Zarzhitsky, J Ziemann, S Zierke, A Zilles, M Zoll
We report the first measurement of the atmospheric electron neutrino flux in the energy range between approximately 80 GeV and 6 TeV, using data recorded during the first year of operation of IceCube's DeepCore low-energy extension. Techniques to identify neutrinos interacting within the DeepCore volume and veto muons originating outside the detector are demonstrated. A sample of 1029 events is observed in 281 days of data, of which 496±66(stat)±88(syst) are estimated to be cascade events, including both electron neutrino and neutral current events...
April 12, 2013: Physical Review Letters
https://www.readbyqxmd.com/read/24966146/evaluation-of-an-ehealth-intervention-in-chronic-care-for-frail-older-people-why-adherence-is-the-first-target
#18
Peter Makai, Marieke Perry, Sarah H M Robben, Henk J Schers, Maud M Heinen, Marcel G M Olde Rikkert, René F Melis
BACKGROUND: Older people suffering from frailty often receive fragmented chronic care from multiple professionals. According to the literature, there is an urgent need for coordination of care. OBJECTIVE: The objective of this study was to investigate the effectiveness of an online health community (OHC) intervention for older people with frailty aimed at facilitating multidisciplinary communication. METHODS: The design was a controlled before-after study with 12 months follow-up in 11 family practices in the eastern part of the Netherlands...
2014: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/24821475/prospective-controlled-cohort-study-to-evaluate-changes-of-function-activity-and-participation-in-patients-with-bilateral-spastic-cerebral-palsy-after-robot-enhanced-repetitive-treadmill-therapy
#19
A S Schroeder, M Homburg, B Warken, H Auffermann, I Koerte, S Berweck, K Jahn, F Heinen, I Borggraefe
BACKGROUND: Robot-enhanced therapies are increasingly being used to improve gross motor performance in patients with cerebral palsy. AIM: To evaluate gross motor function, activity and participation in patients with bilateral spastic cerebral palsy (BS-CP) after Robot-enhanced repetitive treadmill therapy (ROBERT) in a prospective, controlled cohort study. METHODS: Participants trained for 30-60 min in each of 12 sessions within a three-week-period...
July 2014: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/24616430/improved-method-to-retain-cytosolic-reporter-protein-fluorescence-while-staining-for-nuclear-proteins
#20
André P Heinen, Florian Wanke, Sonja Moos, Sebastian Attig, Hervé Luche, Prajna Paramita Pal, Nediljko Budisa, Hans Jörg Fehling, Ari Waisman, Florian C Kurschus
Staining of transcription factors (TFs) together with retention of fluorescent reporter proteins is hindered by loss of fluorescence using current available methods. In this study, it is shown that current TF staining protocols do not destroy fluorescent proteins (FPs) but rather that fixation is not sufficient to retain FPs in the cytosol of the permeabilized cells. In this article, a simple and reliable protocol is elaborated, which allows efficient TF and cytokine staining while retaining FPs inside fixed cells...
July 2014: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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