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https://www.readbyqxmd.com/read/28608552/a-perspective-on-stem-cell-therapy-for-ear-disorders
#1
Rahul Mittal, Hyunseo D Jung, Jeenu Mittal, Adrien A Eshraghi
The use of stem cells in cell-based therapy is an emerging concept for the treatment of ear disorders. Tympanic membrane perforation (TMP) and inner ear disorders are some of the most commonly presented otologic disorders that can benefit from advances in cell-based therapy. Studies have already demonstrated that stem cell-based therapy can potentially be an effective treatment modality for acute and chronic TMP. Recent studies have also shown promise in application of cell-based approach to treat inner ear dysfunction...
June 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28598950/drill-induced-cochlear-injury-during-otologic-surgery-intracochlear-pressure-evidence-of-acoustic-trauma
#2
Renee M Banakis Hartl, Jameson K Mattingly, Nathaniel T Greene, Nyssa F Farrell, Samuel P Gubbels, Daniel J Tollin
HYPOTHESIS: Drilling on the incus produces intracochlear pressure changes comparable to pressures created by high-intensity acoustic stimuli. BACKGROUND: New-onset sensorineural hearing loss (SNHL) following mastoid surgery can occur secondary to inadvertent drilling on the ossicular chain. To investigate this, we test the hypothesis that high sound pressure levels are generated when a high-speed drill contacts the incus. METHODS: Human cadaveric heads underwent mastoidectomy, and fiber-optic sensors were placed in scala tympani and vestibuli to measure intracochlear pressures (PIC)...
June 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28597128/the-mo-meatocanalplasty-a-modification-of-the-m-meatoplasty-to-address-the-superior-quadrants-and-the-bony-canal
#3
Joost van Dinther, Andrzej Zarowski, Thomas Somers, Erwin Offeciers
The meatoplasty of the external auditory canal is a frequently performed otologic procedure in recurrent otitis externa, eczema or frequent accumulation of cerumen due to a narrow meatus of the external ear canal. Numerous surgical techniques have been described. The M-meatoplasty described by Mirck for addressing the external meatus is widely used. However, this technique does not sufficiently enlarge the external ear canal in all cases. Specifically in patients where the ear canal narrowing is most prominent in the postero- and/or anterosuperior quadrants of the lateral meatus the technique needs some modifications...
June 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28596647/audio-vestibular-status-in-cml-patients-on-imatinib-mesylate-with-review-of-literature
#4
Rijuneeta Gupta, Uday Yanamandra, Bhumika Gupta, Naresh K Panda, Subhash Varma, Anu Nagarkar, Pankaj Malhotra
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm occasionally presenting with features of leukostasis as primary symptoms. Hearing loss is occasionally reported in CML patients. Further whether Imatinib mesylate has any effect on vestibular functions is not known. We conducted a preliminary study to assess hearing pattern in patients with CML on long term TKI therapy. This is a single center, cross sectional study from northern-India. Patients of CML who were on regular Tyrosine kinase inhibitors (TKI) therapy for at least 6 months underwent audiovestibular evaluation ...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28594048/-in-vivo-efficacy-of-an-ear-medication-using-gelatin-powder-as-a-vehicle-for-the-therapy-of-canine-otitis-externa
#5
Cosima Bouassiba, Ralf S Mueller
OBJECTIVE: Otitis externa is normally treated with daily topical medication. Longer application intervals may be useful to facilitate therapy. In this study, the in vivo efficacy of a gel preparation containing marbofloxacin, dexamethasone and enilconazole was compared to that of a commercial otologic agent containing marbofloxacin, dexamethasone and clotrimazole based on clinical signs, ear cytology and bacterial/fungal cultures. MATERIAL AND METHODS: A gel preparation (group A) or a registered otologic agent (group B), respectively, was applied to 41 dogs...
June 1, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28589110/citelli-s-abscess-following-otitis-media-a-case-report
#6
Anjan-Kumar Sahoo, Chappity Preetam, Dillip-Kumar Samal, Sourav Sarkar
INTRODUCTION: Citelli's abscess is an extratemporal complication of otitis media. It occurs when pus from the mastoid tip trickles down along the posterior belly of the digastric muscle to the occipital and cervical region. It is a very unusual presenting complication of chronic otitis media with no available data in the until now. CASE REPORT: A 10-year-old female was presented to our outpatient department with a 1 month history of hi-grade fever and headache and pain around the left half of the face...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28588421/evaluation-of-the-safety-and-efficacy-of-a-novel-product-for-the-removal-of-impacted-human-cerumen
#7
Douglas Fullington, Jenny Song, Antionette Gilles, Xiaowen Guo, Waley Hua, C Eric Anderson, Joseph Griffin
BACKGROUND: This open-label study evaluated the safety and efficacy of a novel product for the removal of impacted cerumen in adult patients. METHODS: This was a prospective, single-center, single-arm, self-controlled clinical trial conducted in a community general practice setting. The novel product contains glycolic acid in an otologically-acceptable buffer containing sodium bicarbonate and glycerin and other buffering agents. The product was instilled into the ear canal prior to irrigation with warm water...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/28573831/auditory-and-otologic-profile-of-alstr%C3%A3-m-syndrome-comprehensive-single-center-data-on-38-patients
#8
Spencer Lindsey, Carmen Brewer, Olga Stakhovskaya, Hung Jeffrey Kim, Chris Zalewski, Joy Bryant, Kelly A King, Jürgen K Naggert, William A Gahl, Jan D Marshall, Meral Gunay-Aygun
Alström syndrome (AS) is a rare autosomal recessive ciliopathy caused by mutations in the ALMS1 gene. Hallmark characteristics include childhood onset of severe retinal degeneration, sensorineural hearing loss, obesity, insulin-resistant diabetes, and cardiomyopathy. Here we comprehensively characterize the auditory and otologic manifestations in a prospective case series of 38 individuals, aged 1.7-37.9 years, with genetically confirmed AS. Hearing loss was preceded by retinal dystrophy in all cases, and had an average age of detection of 7...
June 1, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28553354/construct-face-and-content-validation-on-voxel-man%C3%A2-simulator-for-otologic-surgical-training
#9
M Varoquier, C P Hoffmann, C Perrenot, N Tran, C Parietti-Winkler
Objective. To assess the face, content, and construct validity of the Voxel-Man TempoSurg Virtual Reality simulator. Participants and Methods. 74 ear, nose, and throat (ENT) surgeons participated. They were assigned to one of two groups according to their level of expertise: the expert group (n = 16) and the novice group (n = 58). The participants performed four temporal bone dissection tasks on the simulator. Performances were assessed by a global score and then compared to assess the construct validity of the simulator...
2017: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/28532971/clinical-and-audiological-characteristics-of-1000hz-audiometric-notch-patients
#10
Hyun-Min Lee, Seok-Hyun Kim, Jae-Hwan Jung, Se-Joon Oh, Soo-Keun Kong, Il-Woo Lee
PURPOSE: Among the hearing loss patients, we can confirm that the hearing loss of the specific frequency decreases, such as the 2000Hz notch in otosclerosis and the 4000Hz notch (c5-dip) in noise-induced hearing loss. The 1000Hz notch (c3-dip), however, is rarely studied. We fortuitously encountered a group of patients with a 1kHz hearing loss and report it with a review of the literature. METHODS: Otological history, audiogram, diagnosis, occupation, and history of noise exposure were reviewed from charts and telephone interview, and compared between c3-dip and c5-dip patients (n=98)...
April 1, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28530447/middle-ear-function-and-pathophysiology-in-andean-children-living-at-high-altitudes
#11
S Allen Counter, Leo H Buchanan, Fernando Ortega, Anthony B Jacobs, Göran Laurell
Counter, S. Allen, Leo H. Buchanan, Fernando Ortega, Anthony B. Jacobs, and Göran Laurell. Middle ear function and pathophysiology in Andean children living at high altitudes. High Alt Med Biol. 18:163-170, 2017.-The extent of altitude-related middle ear disorders in children native to high altitudes is unclear. This study examined middle ear pathophysiology in two groups of children living in high-altitude Ecuadorian Andean communities by investigating middle ear pressure (MEP), tympanic membrane compliance (TMC), and ear canal volume (ECV) using tympanometry, and by otological examination...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28498266/use-of-positive-airway-pressure-following-middle-ear-surgery-a-practice-survey-of-otologists
#12
Douglas S Ruhl, Anthony M Tolisano, Bradley W Kesser, George T Hashisaki, Macario Camacho
BACKGROUND: Positive airway pressure (PAP) devices are used as treatment for obstructive sleep apnea (OSA). PAP may increase middle ear pressure which is of interest to otologic surgeons. There is a lack of data to guide management of PAP therapy after middle ear surgery. OBJECTIVE: To elucidate how otologic surgeons manage PAP in their patients after ear surgery. STUDY DESIGN: A survey e-mailed to practicing members of the American Neurotology Society...
July 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28485038/a-cross-sectional-evaluation-of-the-validity-of-a-smartphone-otoscopy-device-in-screening-for-ear-disease-in-nepal
#13
R Mandavia, T Lapa, M Smith, M F Bhutta
OBJECTIVES: Hearing loss is a neglected international health problem. The greatest burden of ear disease is in low-income countries where there is also a lack of resources. In this context, screening for otological disease may be worthwhile. Cupris© has developed an otoscopy device that offers the possibility of low-cost mass screening in remote communities. We evaluated the validity of this device in diagnosing ear disease, and in determining whether referral to an ENT centre is warranted...
May 9, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28484680/superior-semicircular-canal-dehiscence-in-a-patient-with-ehlers-danlos-syndrome-a-case-report
#14
Lawrance K Chung, Carlito Lagman, Daniel T Nagasawa, Quinton Gopen, Isaac Yang
Superior semicircular canal dehiscence (SSCD) is a bony defect in the middle cranial fossa floor that results in an abnormal connection between the inner ear and cranial vault. Although the etiology of SSCD remains unclear, an inappropriately thin or fragile temporal bone likely predisposes an individual towards developing SSCD. Ehlers-Danlos syndrome (EDS) constitutes a group of genetic connective tissue disorders caused by a defect in the production, processing, or structure of collagen, or its associated proteins...
April 6, 2017: Curēus
https://www.readbyqxmd.com/read/28483233/high-prevalence-of-abnormalities-on-ct-and-mr-imaging-in-children-with-unilateral-sensorineural-hearing-loss-irrespective-of-age-or-degree-of-hearing-loss
#15
E A van Beeck Calkoen, E Sanchez Aliaga, P Merkus, C F Smit, J M van de Kamp, M F Mulder, S T Goverts, E F Hensen
OBJECTIVE: Evaluation of causal abnormalities identified on CT and MR imaging in children with unilateral sensorineural hearing loss (USNHL), and the association with age and severity of hearing loss. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary referral otology/audiology center. PATIENTS AND DIAGNOSTIC INTERVENTIONS: 102 children diagnosed with USNHL between 2006 and 2016 were included. They underwent CT and/or MR imaging for the evaluation of the etiology of their hearing loss...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28468227/is-presence-of-vascular-loop-in-magnetic-resonance-imaging-always-related-to-tinnitus
#16
Nuray Ensari, Özer Erdem Gür, Ömer Tarik Selçuk, Levent Renda, Üstün Osma, Hülya Eyigör, Bülent Çekiç
INTRODUCTION: One of the most common otological complaints is tinnitus in adults. When there is a complaint of unilateral tinnitus and retrocochlear pathology is suspected, imaging methods are applied. However, the imaging findings obtained may not always be compatible with the severity and localization of the tinnitus. AIM: The aim of the present study was to determine whether or not there was a significant correlation between the findings on magnetic resonance imaging (MRI) and the presence and severity of tinnitus in patients with the complaint of unilateral tinnitus...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28467585/variations-in-otological-presentation-of-lightning-strike-victims-clinical-report-of-3-patients
#17
Erbil Kılıç, Hakan Genç, Ümit Aydın, Burak Aşık, Bülent Satar
Lightning strike can cause fatal or nonfatal injuries. Some nonfatal injuries are associated with otological symptoms and findings. Conductive hearing loss due to rupture of the tympanic membrane is the most common audiovestibular lesion of lightning strike. Various forms of sensorineural hearing loss and dizziness have also been reported. Presently described are 3 cases of lightning strike injury. First patient had mid-frequency hearing loss in right ear and high frequency sensorineural hearing loss in left ear...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28463590/systematic-review-of-ossicular-chain-anatomy-strategic-planning-for-development-of-novel-middle-ear-prostheses
#18
Brandon Kamrava, Pamela C Roehm
Objective To systematically review the anatomy of the ossicular chain. Data Sources Google Scholar, PubMed, and otologic textbooks. Review Methods A systematic literature search was performed on January 26, 2015. Search terms used to discover articles consisted of combinations of 2 keywords. One keyword from both groups was used: [ ossicular, ossicle, malleus, incus, stapes] and [ morphology, morphometric, anatomy, variation, physiology], yielding more than 50,000 hits. Articles were then screened by title and abstract if they did not contain information relevant to human ossicular chain anatomy...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28452718/tinnitus-in-temporomandibular-joint-disorders-is-it-a-specific-somatosensory-tinnitus-subtype
#19
Giuseppe Maria Antonio Algieri, Alessandra Leonardi, Paolo Arangio, Valentino Vellone, Carlo Di Paolo, Piero Cascone
The most significant otologic symptoms, consisting of ear pain, tinnitus, dizziness, hearing loss and auricolar "fullness", generally arise within the auditory system, often are associated with extra auricolar disorders, particularly disorder of the temporo-mandibular joint. In our study we examined a sample of 200 consecutive patients who had experienced severe disabling symptom. The patiens came to maxillofacial specialist assessment for temporomandibular disorder. Each patient was assessed by a detailed anamnestic and clinical temporomandibular joint examination and they are divided into five main groups according classification criteria established by Wilkes; tinnitus and subjective indicators of pain are evaluated...
April 19, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28441806/-possible-reasons-for-cerebrospinal-fluid-gusher-in-cochlear-implantation-with-inner-ear-abnormality
#20
S P Sun, W Lu, X M Men, B Zuo, Y B Lei
Objective: To discuss the possible reasons for cerebrospinal fluid (CSF) gusher in cochlear implantation (CI) with inner ear abnormality. Method: A retrospective analysis was performed on 340 cases who underwent CI from January 2013 to December 2016 in Division of Otology, Otorhinolaryngology Hospital, the First Affiliated Hospital of Zhengzhou University. Among them, 96 cases had inner ear abnormalities. Imaging examinations were performed on these patients, and classification of inner ear malformation was done according to the results...
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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