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https://www.readbyqxmd.com/read/27924984/infrared-imaging-of-high-density-protein-arrays
#1
Joëlle De Meutter, Julie Vandenameele, André Matagne, Erik Goormaghtigh
We propose in this paper that protein microarrays could be analysed by infrared imaging in place of enzymatic or fluorescence labelling. This label-free method reports simultaneously a large series of data on the spotted sample (protein secondary structure, phosphorylation, glycosylation, presence of impurities, etc.). In the present work, 100 μm protein spots each containing about 100 pg protein were deposited to form high density regular arrays. Using arrays of infrared detectors, high resolution images could be obtained where each pixel of the image is in fact a full infrared spectrum...
December 7, 2016: Analyst
https://www.readbyqxmd.com/read/27914373/sparsity-constrained-contrast-source-inversion
#2
Ana B Ramirez, Koen W A van Dongen
Ultrasound imaging is used for detecting and characterizing breast lesions. A state of the art imaging method is the contrast source inversion (CSI), which solves the full wave nonlinear inverse problem. However, when the measurements are acquired in noisy environments, CSI can diverge from the correct solution after several iterations. Problems associated with noisy data were originally solved by including total variation (TV) regularization. Unfortunately, for very noisy data, TV regularization alone is not sufficient...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27913373/mobile-phone-apps-to-improve-medication-adherence-a-systematic-stepwise-process-to-identify-high-quality-apps
#3
Karla Santo, Sarah S Richtering, John Chalmers, Aravinda Thiagalingam, Clara K Chow, Julie Redfern
BACKGROUND: There are a growing number of mobile phone apps available to support people in taking their medications and to improve medication adherence. However, little is known about how these apps differ in terms of features, quality, and effectiveness. OBJECTIVE: We aimed to systematically review the medication reminder apps available in the Australian iTunes store and Google Play to assess their features and their quality in order to identify high-quality apps...
December 2, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27907890/association-of-muscle-endurance-fatigability-and-strength-with-functional-limitation-and-mortality-in-the-health-aging-and-body-composition-study
#4
Baback Roshanravan, Kushang V Patel, Linda F Fried, Cassianne Robinson-Cohen, Ian H de Boer, Tamara Harris, Rachel A Murphy, Suzanne Satterfield, Bret H Goodpaster, Michael Shlipak, Anne B Newman, Bryan Kestenbaum
BACKGROUND: Mobility limitation is highly prevalent among older adults and is central to the loss of functional independence. Dynamic isokinetic muscle fatigue testing may reveal increased vulnerability to disability and mortality beyond strength testing. METHODS: We studied community-dwelling older adults enrolled in the Health Aging and Body Composition study (age range: 71-82) free of mobility disability and who underwent isokinetic muscle fatigue testing in 1999-2000 (n = 1,963)...
October 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27881187/class-solutions-for-sabr-vmat-for-high-risk-prostate-cancer-with-and-without-elective-nodal-irradiation
#5
Sarah O S Osman, Prakash Jeevanandam, Nithya Kanakavelu, Denise M Irvine, Ciara A Lyons, Suneil Jain, Alan R Hounsell, Conor K McGarry
BACKGROUND: The purpose of this study is to find the optimal planning settings for prostate SABR-VMAT for high-risk prostate cancer patients irradiated to prostate only (PO) or prostate and pelvic lymph nodes (PPLN). METHODS: For 10 patients, plans using 6MV flattened, flattening-filter-free (FFF) 6MV (6 F) and FFF 10MV (10 F) photon beams with full and partial arc arrangements were generated and compared. The prescribed dose was 40Gy to the prostate with 25Gy to the PLN in 5 fractions...
November 24, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27878562/full-dose-perindopril-indapamide-in-the-treatment-of-difficult-to-control-hypertension-the-fortissimo-study
#6
Yuri Aleksandrovich Karpov
BACKGROUND AND OBJECTIVE: Blood pressure (BP) control in hypertensive patients remains poor worldwide, particularly in high-risk patients with hypertension and diabetes. Guidelines recommend that such patients receive prompt pharmacological therapy at maximal doses to rapidly control BP. We aimed to evaluate efficacy and safety of single-pill combination (SPC) perindopril/indapamide (PER/IND) at full dose (10/2.5 mg) in hypertensive patients, including diabetics, with BP uncontrolled by previous medication...
November 22, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27878374/agents-for-fluorescence-guided-glioma-surgery-a-systematic-review-of-preclinical-and-clinical-results
#7
REVIEW
Joeky T Senders, Ivo S Muskens, Rosalie Schnoor, Aditya V Karhade, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma. METHODS: We searched the PubMed and Embase databases for all potentially relevant studies through March 2016...
November 22, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27874323/flotation-of-toxocara-canis-eggs-in-commercial-bleach-and-effects-of-bleach-treatment-times-on-larval-development-in-these-eggs
#8
Alexa C Rosypal, Alice Houk-Miles, Anne M Zajac, David S Lindsay
Toxocara canis is a common intestinal nematode of young dogs. Puppies contaminate the environment with large numbers of eggs that can embryonate and become infective in less than a month. Embryonated eggs are infectious for humans and other paratenic hosts. Most T. canis infections in humans are asymptomatic, however, migration of T. canis larvae in the eye and in the central nervous system can result in vision loss, blindness, and even death. The eggs of T. canis are highly resistant to harsh environmental conditions and routinely used chemical disinfectants...
November 22, 2016: Journal of Parasitology
https://www.readbyqxmd.com/read/27871316/heterogeneous-antigenic-properties-of-the-porcine-reproductive-and-respiratory-syndrome-virus-nucleocapsid
#9
Julie C F Rappe, Obdulio García-Nicolás, Franziska Flückiger, Barbara Thür, Martin A Hofmann, Artur Summerfield, Nicolas Ruggli
Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus responsible for a widespread contagious disease of domestic pigs with high economic impact. Switzerland is one of the rare PRRSV-free countries in Europe, although sporadic outbreaks have occurred in the past. The PRRSV isolate IVI-1173 from the short outbreak in Switzerland in 2012 was entirely sequenced, and a functional full-length cDNA clone was constructed. Genetic and antigenic characterization of IVI-1173 revealed the importance of amino acid 90 of the nucleocapsid protein N as part of a conformational epitope...
November 21, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27871092/the-effect-of-rib-shape-on-stiffness
#10
Sven A Holcombe, Stewart C Wang, James B Grotberg
This study investigates the isolated effect of rib shape on the mechanical characteristics of ribs subjected to multiple forms of loading. It aims to measure the variation in stiffness due to shape that is seen throughout the population and, in particular, provide a tool for researchers to better understand the influence of shape on resulting stiffness. A previously published six-parameter shape model of the central axis of human ribs was used. It has been shown to accurately model the overall rib path using intrinsic geometric properties such as size, aspect ratio, and skewness, through shapes based on logarithmic spirals with high curvature continuity...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27870126/discovery-of-therapeutic-approaches-for-polyglutamine-diseases-a-summary-of-recent-efforts
#11
REVIEW
Sofia Esteves, Sara Duarte-Silva, Patrícia Maciel
Polyglutamine (PolyQ) diseases are a group of neurodegenerative disorders caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the coding region of specific genes. This leads to the production of pathogenic proteins containing critically expanded tracts of glutamines. Although polyQ diseases are individually rare, the fact that these nine diseases are irreversibly progressive over 10 to 30 years, severely impairing and ultimately fatal, usually implicating the full-time patient support by a caregiver for long time periods, makes their economic and social impact quite significant...
November 21, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/27869298/informant-questionnaire-on-cognitive-decline-in-the-elderly-iqcode-for-the-early-diagnosis-of-dementia-across-a-variety-of-healthcare-settings
#12
REVIEW
Jennifer K Harrison, David J Stott, Rupert McShane, Anna H Noel-Storr, Rhiannon S Swann-Price, Terry J Quinn
BACKGROUND: The Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) is a structured interview based on informant responses that is used to assess for possible dementia. IQCODE has been used for retrospective or contemporaneous assessment of cognitive decline. There is considerable interest in tests that may identify those at future risk of developing dementia. Assessing a population free of dementia for the prospective development of dementia is an approach often used in studies of dementia biomarkers...
November 21, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27867723/all-optical-highly-sensitive-akinetic-sensor-for-ultrasound-detection-and-photoacoustic-imaging
#13
Stefan Preisser, Wolfgang Rohringer, Mengyang Liu, Christian Kollmann, Stefan Zotter, Balthasar Fischer, Wolfgang Drexler
A novel all-optical akinetic ultrasound sensor, consisting of a rigid, fiber-coupled Fabry-Pérot etalon with a transparent central opening is presented. The sensing principle relies exclusively on the detection of pressure-induced changes of the refractive index in the fluid filling the Fabry-Pérot cavity. This enables resonance-free, inherently linear signal detection over a broad bandwidth. We demonstrate that the sensor achieves a exceptionally low peak noise equivalent pressure (NEP) values of 2 Pa over a 20 MHz measurement bandwidth (without signal averaging), while maintaining a flat frequency response, and a detection bandwidth up to 22...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27855938/acrylamide-forming-potential-of-potatoes-grown-at-different-locations-and-the-ratio-of-free-asparagine-to-reducing-sugars-at-which-free-asparagine-becomes-a-limiting-factor-for-acrylamide-formation
#14
Nira Muttucumaru, Stephen J Powers, J Stephen Elmore, Andrew Dodson, Adrian Briddon, Donald S Mottram, Nigel G Halford
Acrylamide is produced from free asparagine and reducing sugars during high-temperature cooking and food processing, and potato products are major contributors to dietary acrylamide intake. The present study analysed twenty varieties of potatoes grown at two sites (Doncaster and Woburn) in the United Kingdom to assess the effect of location of cultivation on acrylamide-forming potential. Analysis of variance revealed a full site by variety nested within type (French fry, boiling and crisping) by storage interaction for acrylamide (p<0...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27835987/clinicopathological-and-prognostic-significance-of-mtor-and-phosphorylated-mtor-expression-in-patients-with-esophageal-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#15
Shuangjiang Li, Zhiqiang Wang, Jian Huang, Shan Cheng, Heng Du, Guowei Che, Yong Peng
BACKGROUND: Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase responsible for regulating ribosomal biogenesis and protein synthesis. Dysregulation of mTOR contributes to tumorigenesis, angiogenesis, cellular growth and metastasis but its roles in esophageal squamous cell carcinoma (ESCC) are controversial. Therefore, the objective of this study is to evaluate the prognostic and clinicopathological significance of mTOR/p-mTOR expression in ESCC. METHODS: Literature retrieval was conducted by searching PubMed, EMBASE and the Web of Science for full-text papers that met our eligibility criteria...
November 11, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27835934/the-conformational-feasibility-for-the-formation-of-reaching-dimer-in-asv-and-hiv-integrase-a-molecular-dynamics-study
#16
Sangeetha Balasubramanian, Muthukumaran Rajagopalan, Ravi Shankar Bojja, Anna Marie Skalka, Mark D Andrake, Amutha Ramaswamy
Retroviral integrases are reported to form alternate dimer assemblies like the core-core dimer and reaching dimer. The core-core dimer is stabilized predominantly by an extensive interface between two catalytic core domains. The reaching dimer is stabilized by N-terminal domains (NTD) that reach to form intermolecular interfaces with the other subunit's core and C-terminal domains (CTD), as well as CTD-CTD interactions. In this study, molecular dynamics (MD), Brownian dynamics (BD) simulations, and free energy analyses, were performed to elucidate determinants for the stability of the reaching dimer forms of full-length ASV and HIV IN, and to examine the role of the C-tails (the last ~16-18 residues at the C-termini) in their structural dynamics...
November 11, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27822536/a-universal-next-generation-sequencing-protocol-to-generate-noninfectious-barcoded-cdna-libraries-from-high-containment-rna-viruses
#17
Lindsey A Moser, Lisbeth Ramirez-Carvajal, Vinita Puri, Steven J Pauszek, Krystal Matthews, Kari A Dilley, Clancy Mullan, Jennifer McGraw, Michael Khayat, Karen Beeri, Anthony Yee, Vivien Dugan, Mark T Heise, Matthew B Frieman, Luis L Rodriguez, Kristen A Bernard, David E Wentworth, Timothy B Stockwell, Reed S Shabman
Several biosafety level 3 and/or 4 (BSL-3/4) pathogens are high-consequence, single-stranded RNA viruses, and their genomes, when introduced into permissive cells, are infectious. Moreover, many of these viruses are select agents (SAs), and their genomes are also considered SAs. For this reason, cDNAs and/or their derivatives must be tested to ensure the absence of infectious virus and/or viral RNA before transfer out of the BSL-3/4 and/or SA laboratory. This tremendously limits the capacity to conduct viral genomic research, particularly the application of next-generation sequencing (NGS)...
May 2016: MSystems
https://www.readbyqxmd.com/read/27816030/surgical-management-of-arrested-hydrocephalus-case-report-literature-review-and-18-month-follow-up
#18
Jennifer Hong, Benjamin G Barrena, S Scott Lollis, David F Bauer
OBJECTIVE: Arrested hydrocephalus is stable ventriculomegaly without evidence of neurologic deterioration or symptoms. Management of arrested hydrocephalus in asymptomatic adults is controversial, with little clinical data. This case highlights the potential for decompensation in adults with arrested hydrocephalus and reviews the literature regarding pathophysiology and management of this clinical entity. PATIENTS AND METHODS: A 39 year-old gentleman with arrested hydrocephalus incidentally found during work-up for new-onset seizure and managed conservatively for ten years presented with increasing headache, memory loss, gait instability and urinary and fecal incontinence...
December 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27811322/molecular-characterization-of-chicken-infectious-anemia-virus-from-contaminated-live-virus-vaccines
#19
Yang Li, Yan Hu, Shuai Cui, Jiayuan Fu, Yixin Wang, Zhizhong Cui, Lichun Fang, Shuang Chang, Peng Zhao
The aim of this study was to investigate possible causes of the pervasiveness of chicken infectious anemia virus ( CIAV: ) infection in chickens in recent years in China. A total of 14 batches of live-virus vaccines were examined using PCR to detect CIAV contamination, of which only 2 samples (a Newcastle disease vaccine and a fowl pox vaccine) tested positive for CIAV. These Newcastle and fowl pox vaccines were then inoculated into 1-day-old specific-pathogen-free chickens. Serum samples were collected from chickens infected with the PCR-positive vaccines, and these tested positive for CIAV-specific antibodies as tested using ELISA...
November 2, 2016: Poultry Science
https://www.readbyqxmd.com/read/27809684/the-association-between-changes-in-thyroid-hormones-and-incident-type-2-diabetes-a-7-year-longitudinal-study
#20
Ji Eun Jun, Sang Man Jin, Ji Cheol Bae, Jae Hwan Jee, Kyu Yeon Hur, Moon-Kyu Lee, Tae Hyuk Kim, Sun Wook Kim, Jae Hyeon Kim
BACKGROUND: Thyroid hormones are important regulators of glucose homeostasis; however, the association between thyroid hormones within the reference range and type 2 diabetes remains unclear. The aim of this study was to clarify the incidence of type 2 diabetes according to the baseline levels and changes of thyroid stimulating hormone (TSH) and thyroid hormones (free thyroxine [FT4] and triiodothyronine [T3]) in euthyroid subjects. METHODS: Among the participants who consecutively underwent thyroid function tests between 2006 and 2012 through a yearly health check-up program, 6,235 euthyroid subjects (3,619 men and 2,616 women) without diabetes were enrolled in the study...
November 3, 2016: Thyroid: Official Journal of the American Thyroid Association
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