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https://www.readbyqxmd.com/read/29782146/multiscale-interfacial-strategy-to-engineer-mixed-metal-oxide-anodes-towards-an-enhanced-cycling-efficiency
#1
Yue Ma, Cheuk-Wai Tai, Shaowen Li, Kristina Edstrom, Bingqing Wei
Interconnected macro/mesoporous structures of mixed metal oxide (MMO) are developed on nickel foam as free-standing anodes for Li-ion batteries. The sustainable production is realized via a wet chemical etching process with bio-friendly chemicals. By means of the divalent iron doping during an in-situ re-crystallization process, the as-developed MMO anodes exhibit the enhanced levels of cycling efficiency. Furthermore, this atomic-scale modification coherently synergies with the encapsulation layer across a micrometer scale...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29762754/optimized-distributed-systems-achieve-significant-performance-improvement-on-sorted-merging-of-massive-vcf-files
#2
Xiaobo Sun, Jingjing Gao, Peng Jin, Celeste Eng, Esteban G Burchard, Terri H Beaty, Ingo Ruczinski, Rasika A Mathias, Kathleen C Barnes, Fusheng Wang, Zhaohui Qin
Background: Sorted merging of genomic data is a common data operation necessary in many sequencing-based studies. It involves sorting and merging genomic data from different subjects by their genomic locations. In particular, merging a large number of Variant Call Format (VCF) files is frequently required in large scale whole genome sequencing or whole exome sequencing projects. Traditional single machine based methods become increasingly inefficient when processing large numbers of VCF files due to the excessive computation time and I/O bottleneck...
May 11, 2018: GigaScience
https://www.readbyqxmd.com/read/29761659/ruthenium-supported-on-high-surface-area-zirconia-as-an-efficient-catalyst-for-the-base-free-oxidation-of-5-hydroxymethylfurfural-to-2-5-furandicarboxylic-acid
#3
Christian M Pichler, Mohammad Ghith Al-Shaal, Dong Gu, Hrishikesh Joshi, Wirawan Ciptonugroho, Ferdi Schüth
Different ZrO2 supported ruthenium catalysts were prepared and utilized in the oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) under base-free conditions. Full conversion of HMF and almost perfect selectivity towards FDCA (97%) were achieved after 16 h, using pure O2 as an oxidant and water as a solvent. The catalytic tests show that the size of the Ru particles is crucial for the catalytic performance and that the utilization of high surface area ZrO2 leads to formation of very small Ru particles...
May 15, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29753448/widefield-high-frame-rate-single-photon-spad-imagers-for-spim-fcs
#4
Jan Buchholz, Jan Krieger, Claudio Bruschini, Samuel Burri, Andrei Ardelean, Edoardo Charbon, Jörg Langowski
Photon-counting sensors based on standard complementary metal-oxide-semiconductor single-photon avalanche diodes (SPADs) represent an emerging class of imagers that enable the counting and/or timing of single photons at zero readout noise (better than high-speed electron-multiplying charge-coupling devices) and over large arrays. They have seen substantial progress over the last 15 years, increasing their spatial resolution, timing accuracy, and sensitivity while reducing spurious signals such as afterpulsing and dark counts...
May 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29742889/intraoperative-neurophysiological-monitoring-a-review-of-techniques-used-for-brain-tumor-surgery-in-children
#5
REVIEW
Keewon Kim, Charles Cho, Moon-Suk Bang, Hyung-Ik Shin, Ji-Hoon Phi, Seung-Ki Kim
Intraoperative monitoring (IOM) utilizes electrophysiological techniques as a surrogate test and evaluation of nervous function while a patient is under general anesthesia. They are increasingly used for procedures, both surgical and endovascular, to avoid injury during an operation, examine neurological tissue to guide the surgery, or to test electrophysiological function to allow for more complete resection or corrections. The application of IOM during pediatric brain tumor resections encompasses a unique set of technical issues...
May 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29742186/factors-affecting-dermatologists-use-of-a-31-gene-expression-profiling-test-as-an-adjunct-for-predicting-metastatic-risk-in-cutaneous-melanoma
#6
Ryan M Svoboda, Alex M Glazer, Aaron S Farberg, Darrell S Rigel
IMPORTANCE: A 31-gene expression profile (31-GEP) test to predict metastatic risk in patients with cutaneous malignant melanoma has previously been validated and is available for clinical use. The impact of the availability of such a test on clinical decision-making has previously been studied. However, little is known about which factors play a role in clinicians' decision to utilize the test. OBJECTIVE: To determine factors affecting clinicians' decisions to utilize the 31-GEP test for metastatic risk stratification in patients with cutaneous malignant melanoma...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29740442/stability-of-chimerism-in-non-obese-diabetic-mice-achieved-by-rapid-t-cell-depletion-is-associated-with-high-levels-of-donor-cells-very-early-after-transplant
#7
Jiaxin Lin, William F N Chan, Louis Boon, Colin C Anderson
Stable mixed hematopoietic chimerism is a robust method for inducing donor-specific tolerance with the potential to prevent rejection of donor islets in recipients with autoimmune type-1 diabetes. However, with reduced intensity conditioning, fully allogeneic chimerism in a tolerance resistant autoimmune-prone non-obese diabetic (NOD) recipient has rarely been successful. In this setting, successful multilineage chimerism has required either partial major histocompatability complex matching, mega doses of bone marrow, or conditioning approaches that are not currently clinically feasible...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29730836/round-robin-test-for-the-cell-of-origin-classification-of-diffuse-large-b-cell-lymphoma-a-feasibility-study-using-full-slide-staining
#8
Sarah Reinke, Julia Richter, Falko Fend, Alfred Feller, Martin-Leo Hansmann, Katrin Hüttl, Ilske Oschlies, German Ott, Peter Möller, Andreas Rosenwald, Harald Stein, Michael Altenbuchinger, Rainer Spang, Wolfram Klapper
Diffuse large B-cell lymphoma (DLBCL) is subdivided by gene expression analysis (GEP) into two molecular subtypes named germinal center B-cell-like (GCB) and activated B-cell-like (ABC) after their putative cell-of-origin (COO). Determination of the COO is considered mandatory in any new-diagnosed DLBCL, not otherwise specified according to the updated WHO classification. Despite the fact that pathologists are free to choose the method for COO classification, immunohistochemical (IHC) assays are most widely used...
May 5, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29729597/temporal-stability-of-posterior-eeg-alpha-over-twelve-years
#9
Craig E Tenke, Jürgen Kayser, Jorge E Alvarenga, Karen S Abraham, Virginia Warner, Ardesheer Talati, Myrna M Weissman, Gerard E Bruder
OBJECTIVE: We previously identified posterior EEG alpha as a potential biomarker for antidepressant treatment response. To meet the definition of a trait biomarker or endophenotype, it should be independent of the course of depression. Accordingly, this report evaluated the temporal stability of posterior EEG alpha at rest. METHODS: Resting EEG was recorded from 70 participants (29 male; 46 adults), during testing sessions separated by 12 ± 1.1 years. EEG alpha was identified, separated and quantified using reference-free methods that combine current source density (CSD) with principal components analysis (PCA)...
April 16, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29715691/vp-nets-efficient-automatic-localization-of-key-brain-structures-in-3d-fetal-neurosonography
#10
Ruobing Huang, Weidi Xie, J Alison Noble
Three-dimensional (3D) fetal neurosonography is used clinically to detect cerebral abnormalities and to assess growth in the developing brain. However, manual identification of key brain structures in 3D ultrasound images requires expertise to perform and even then is tedious. Inspired by how sonographers view and interact with volumes during real-time clinical scanning, we propose an efficient automatic method to simultaneously localize multiple brain structures in 3D fetal neurosonography. The proposed View-based Projection Networks (VP-Nets), uses three view-based Convolutional Neural Networks (CNNs), to simplify 3D localizations by directly predicting 2D projections of the key structures onto three anatomical views...
April 23, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29712487/prospective-study-of-myelin-water-fraction-changes-after-mild-traumatic-brain-injury-in-collegiate-contact-sports
#11
Heather S Spader, Douglas C Dean, W Curt LaFrance, Neha P Raukar, G Rees Cosgrove, Stephanie A Eyerly-Webb, Anna Ellermeier, Stephen Correia, Sean C L Deoni, Jeffrey Rogg
OBJECTIVE Mild traumatic brain injury (mTBI) in athletes, including concussion, is increasingly being found to have long-term sequelae. Current imaging techniques have not been able to identify early damage caused by mTBI that is predictive of long-term symptoms or chronic traumatic encephalopathy. In this preliminary feasibility study, the authors investigated the use of an emerging magnetic resonance imaging (MRI) technique, multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT), in visualizing acute and chronic white matter changes after mTBI in collegiate football and rugby players...
May 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29701608/quantitative-myocardial-perfusion-from-static-cardiac-and-dynamic-arterial-ct
#12
Michael Bindschadler, Kelley R Branch, Adam M Alessio
Quantitative myocardial blood flow (MBF) estimation by dynamic contrast enhanced cardiac computed tomography (CT) requires multi-frame acquisition of contrast transit through the blood pool and myocardium to inform the arterial input and tissue response functions. Both the input and the tissue response functions for the entire myocardium are sampled with each acquisition. However, the long breath holds and frequent sampling can result in significant motion artifacts and relatively high radiation dose. To address these limitations, we propose and evaluate a new static cardiac and dynamic arterial (SCDA) quantitative MBF approach where 1) the input function is well sampled using either prediction from pre-scan timing bolus data or measured from dynamic thin slice "bolus tracking" acquisitions, and 2) the whole-heart tissue response data is limited to one contrast enhanced CT acquisition...
April 27, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29696405/gastric-washing-by-distilled-water-can-reduce-free-gastric-cancer-cells-exfoliated-into-the-stomach-lumen
#13
Atsuko Ohki, Nobutsugu Abe, Eri Yoshimoto, Yoshikazu Hashimoto, Hirohisa Takeuchi, Gen Nagao, Tadahiko Masaki, Toshiyuki Mori, Yasuo Ohkura, Masanori Sugiyama
PURPOSE: Intragastric free cancer cells in patients with gastric cancer have rarely been studied. The purpose of this study was to investigate the detection rate of intragastric free cancer cells in gastric washes using two types of solutions during endoscopic examination. We further clarified risk factors affecting the presence of exfoliated free cancer cells. METHODS: A total of 175 patients with gastric cancer were enrolled. Lactated Ringer's solution (N = 89) or distilled water (DW; N = 86) via endoscopic working channel was sprayed onto the tumor surface, and the resultant fluid was collected for cytological examination...
April 25, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29692025/-responses-of-diurnal-variation-of-flag-leaf-photosynthesis-and-photosynthetic-pigment-content-to-elevated-atmospheric-co-2-concentration-and-temperature-of-japonica-rice-during-late-growth-stage-a-face-study
#14
Man Man Yuan, Jian Guo Zhu, Gang Liu, Wei Lu Wang
A local popular Japonica rice (Oryza sating L.) cultivar, Nanjing 9108, was tested with free air controlled enrichment (FACE) approach to study the responses of photosynthetic pigment content and diurnal variation of flag-leaf photosynthesis to elevated atmospheric CO2 concentration and temperature. Four alternative treatments were designed with two CO2 concentration levels (ambient and elevated 200 μmol·mol-1 ) and two air temperature regimes (ambient and elevated 1-2 ℃). Diurnal variation of flag-leaf photosynthesis was measured in the middle full stage and the late full stage, and photosynthetic pigment of the leaf was analyzed afterward...
January 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29690603/proximity-induced-artefacts-in-magnetic-imaging-with-nitrogen-vacancy-ensembles-in-diamond
#15
Jean-Philippe Tetienne, David A Broadway, Scott E Lillie, Nikolai Dontschuk, Tokuyuki Teraji, Liam T Hall, Alastair Stacey, David A Simpson, Lloyd C L Hollenberg
Magnetic imaging with ensembles of nitrogen-vacancy (NV) centres in diamond is a recently developed technique that allows for quantitative vector field mapping. Here we uncover a source of artefacts in the measured magnetic field in situations where the magnetic sample is placed in close proximity (a few tens of nm) to the NV sensing layer. Using magnetic nanoparticles as a test sample, we find that the measured field deviates significantly from the calculated field, in shape, amplitude and even in sign. By modelling the full measurement process, we show that these discrepancies are caused by the limited measurement range of NV sensors combined with the finite spatial resolution of the optical readout...
April 23, 2018: Sensors
https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#16
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29665930/-system-amplifying-nk-cells-using-mononuclear-cell-culture
#17
Shi-Jian Huang, Hong-Min Yan, Zi-Kuan Guo
OBJECTIVE: To develop an easy method to amplify natural killer (NK) cells by using mononuclear cells in vitro, so as to lay the basis for NK cell therapy. METHODS: Umbilical cord blood from 3 healthy full-term pregnant women was collected, and the peripheral blood mononuclear cells (PBMNC) were harvested by density gradient centrifugation. Each sample of PBMNC was divided into 3 groups: CD16mAb, CD3 mAb and CD16mAb+CD3mAb- groups. The culture flasks were pre-coated with CD16, CD3 or CD3 plus CD16 mAb...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29659933/circulating-tumor-cells-in-breast-cancer-patients-treated-by-neoadjuvant-chemotherapy-a-meta-analysis
#18
François-Clément Bidard, Stefan Michiels, Sabine Riethdorf, Volkmar Mueller, Laura J Esserman, Anthony Lucci, Bjørn Naume, Jun Horiguchi, Rafael Gisbert-Criado, Stefan Sleijfer, Masakazu Toi, Jose A Garcia-Saenz, Andreas Hartkopf, Daniele Generali, Françoise Rothé, Jeffrey Smerage, Laura Muinelo-Romay, Justin Stebbing, Patrice Viens, Mark Jesus M Magbanua, Carolyn S Hall, Olav Engebraaten, Daisuke Takata, José Vidal-Martínez, Wendy Onstenk, Noriyoshi Fujisawa, Eduardo Diaz-Rubio, Florin-Andrei Taran, Maria Rosa Cappelletti, Michail Ignatiadis, Charlotte Proudhon, Denise M Wolf, Jessica B Bauldry, Elin Borgen, Rin Nagaoka, Vicente Carañana, Jaco Kraan, Marisa Maestro, Sara Yvonne Brucker, Karsten Weber, Fabien Reyal, Dominic Amara, Mandar G Karhade, Randi R Mathiesen, Hideaki Tokiniwa, Antonio Llombart-Cussac, Alessandra Meddis, Paul Blanche, Koenraad d'Hollander, Klaus Pantel
Background: We conducted a meta-analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker. Methods: We collected individual patient data from 21 studies in which CTC detection by CellSearch was performed in early breast cancer patients treated with NCT. The primary end point was overall survival, analyzed according to CTC detection, using Cox regression models stratified by study...
April 12, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29653177/additive-potential-of-combination-therapy-against-cryptococcosis-employing-a-novel-amphotericin-b-and-fluconazole-loaded-dual-delivery-system
#19
Azmat Ali Khan, Amer M Alanazi, Mumtaz Jabeen, Shahnavaj Khan, Abdul Mallik
Cryptococcus neoformans is one of the most lethal fungi causing mortality across the globe with the highest incidences in immuno-compromised person. Patients taking immuno-suppressive medications and immuno-competent hosts are extremely susceptible to its infection. Thus, new forms of therapy are urgently required for effective cure to the fungal burden. So, in the present study we have tried to explore the potential effects of amphotericin B (AMB) and fluconazole (FLC) in combination antifungal drug therapy...
April 10, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29614264/spatial-correlation-as-an-early-warning-signal-of-regime-shifts-in-a-multiplex-disease-behaviour-network
#20
Peter C Jentsch, Madhur Anand, Chris T Bauch
Early warning signals of sudden regime shifts are a widely studied phenomenon for their ability to quantify a system's proximity to a tipping point to a new and contrasting dynamical regime. However, this effect has been little studied in the context of the complex interactions between disease dynamics and vaccinating behaviour. Our objective was to determine whether critical slowing down (CSD) occurs in a multiplex network that captures opinion propagation on one network layer and disease spread on a second network layer...
March 31, 2018: Journal of Theoretical Biology
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