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https://www.readbyqxmd.com/read/28917598/matrix-effect-free-quantitative-liquid-chromatography-mass-spectrometry-analysis-in-complex-matrices-using-nanoflow-lc-with-integrated-emitter-tip-and-high-dilution-factors
#1
David Moreno-González, Jaime Alcántara-Durán, Bienvenida Gilbert-López, Juan F García-Reyes, Antonio Molina-Díaz
Matrix effects are probably the Achilles heel of most quantitative liquid chromatography mass spectrometry (LC-MS) methods based on electrospray ionization. This work reports the evaluation of matrix effects in challenging matrices such as food extracts, human urine or wastewater at different dilution factors using nanoflow liquid chromatography-high resolution mass spectrometry (LC-MS). For this purpose, a suite of representative low-molecular weight compounds such as pesticides, drugs of abuse, sport drugs or environmental contaminants were selected...
September 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28917157/density-of-calcium-in-the-ascending-thoracic-aorta-and-risk-of-incident-cardiovascular-disease-events
#2
Isac C Thomas, Robyn L McClelland, Erin D Michos, Matthew A Allison, Nketi I Forbang, W T Longstreth, Wendy S Post, Nathan D Wong, Matthew J Budoff, Michael H Criqui
BACKGROUND AND AIMS: The volume and density of coronary artery calcium (CAC) both independently predict cardiovascular disease (CVD) beyond standard risk factors, with CAC density inversely associated with incident CVD after accounting for CAC volume. We tested the hypothesis that ascending thoracic aorta calcium (ATAC) volume and density predict incident CVD events independently of CAC. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of participants without clinical CVD at baseline...
September 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28916243/feasibility-and-accuracy-of-automated-software-for-transthoracic-three-dimensional-left-ventricular-volume-and-function-analysis-comparisons-with-two-dimensional-echocardiography-three-dimensional-transthoracic-manual-method-and-cardiac-magnetic-resonance-imaging
#3
Gloria Tamborini, Concetta Piazzese, Roberto M Lang, Manuela Muratori, Elisa Chiorino, Massimo Mapelli, Laura Fusini, Sarah Ghulam Ali, Paola Gripari, Gianluca Pontone, Daniele Andreini, Mauro Pepi
BACKGROUND: Recently, a new automated software package (HeartModel) was developed to obtain three-dimensional (3D) left ventricular (LV) volumes using a model-based algorithm (MBA) with a "one-button" simple system and user-adjustable slider. The aims of this study were to verify the feasibility and accuracy of the MBA in comparison with other commonly used imaging techniques in a large unselected population, to evaluate possible accuracy improvements of free operator border adjustments or changes of the slider's default position, and to identify differences in method accuracy related to specific pathologies...
September 12, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28910530/an-efficient-implicit-solvation-method-for-full-potential-dft
#4
Markus Sinstein, Christoph Scheurer, Sebastian Matera, Volker Blum, Karsten Reuter, Harald Oberhofer
With the advent of efficient electronic structure methods, effective continuum solvation methods have emerged as a way to, at least partially, include solvent effects into simulations without the need for expensive sampling over solvent degrees of freedom. The multipole moment expansion (MPE) model, while based on ideas initially put forward almost 100 years ago, has recently been updated for the needs of modern electronic structure calculations. Indeed, for an all-electron code relying on localized basis sets and---more importantly---a multipole moment expansion of the electrostatic potential, the MPE method presents a particularly cheap way of solving the macroscopic Poisson equation to determine the electrostatic response of a medium surrounding a solute...
September 14, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28906387/a-nearly-full-recovery-from-avm-hemorrhagic-stroke-17-years-after-insult-using-a-new-integrated-neurodevelopmental-approach-a-case-report
#5
Alberto J Friedmann
RATIONAL: With the prevalence of stroke increasing in the USA and the world along with increased survival and longevity due to medical advancements, it has become increasingly necessary to look at the chronic phase of stroke recovery. Previous paradigms of stroke treatment have proven ineffective when looking at 10, 15, or 20 years of survival post insult. PATIENT CONCERNS: The patient, being a young man just out of high school, was concerned with his overall morbidity...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28904545/the-effects-of-massage-and-breastfeeding-on-response-to-venipuncture-pain-among-hospitalized-neonates
#6
Ali Zargham-Boroujeni, Azamolmolouk Elsagh, Majid Mohammadizadeh
BACKGROUND: Untreated procedural pain leads to long-term and short-term complications in neonates. Preventing pain in sick infants and neonates, whose conditions are getting worse, not only is a professional and legal duty but also a prevention measure to decrease future psychological and even neurological complications. Therefore, nurses should prevent newborns' pain. The aim of this study was to compare the effects of massage and breastfeeding on the pain of the neonates. MATERIALS AND METHODS: This was a clinical trial conducted among 75 full-term and near-term infants who underwent venipuncture...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28900572/return-to-running-following-a-knee-disarticulation-amputation-a-case-report
#7
Angela R Diebal-Lee, Robert S Kuenzi, Christopher A Rábago
BACKGROUND AND PURPOSE: The evolution of running-specific prostheses has empowered athletes with lower extremity amputations to run farther and faster than previously thought possible; but running with proper mechanics is still paramount to an injury-free, active lifestyle. The purpose of this case report was to describe the successful alteration of intact limb mechanics from a Rearfoot Striking (RFS) to a Non-Rearfoot Striking (NRFS) pattern in an individual with a knee disarticulation amputation, the associated reduction in Average Vertical Loading Rate (AVLR), and the improvement in functional performance following the intervention...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28883920/exogenous-t3-toxicosis-following-consumption-of-a-contaminated-weight-loss-supplement
#8
R D'Arcy, M McDonnell, K Spence, C H Courtney
A 42-year-old male presented with a one-week history of palpitations and sweating episodes. The only significant history was of longstanding idiopathic dilated cardiomyopathy. Initial ECG demonstrated a sinus tachycardia. Thyroid function testing, undertaken as part of the diagnostic workup, revealed an un-measureable thyroid-stimulating hormone (TSH) and free thyroxine (T4). Upon questioning the patient reported classical thyrotoxic symptoms over the preceding weeks. Given the persistence of symptoms free tri-iodothyronine (T3) was measured and found to be markedly elevated at 48...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28881332/reverse-shoulder-arthroplasty-for-deltoid-deficient-shoulder-following-latissimus-dorsi-flap-transfer-case-report
#9
Mohamed Al Ateeq Al Dosari, Shamsi Hameed, Khalid Mukhtar, Aissam Elmhiregh
INTRODUCTION: The usual indication for reverse shoulder arthroplasty is glenohumeral arthritis with inadequate rotator cuff and intact deltoid muscle. We report here a case of reverse shoulder arthroplasty using a lattisimus dorsi flap in a patient with deltoid-deficient shoulder following a gunshot injury. PRESENTATION OF THE CASE: The patient was an otherwise healthy 51-year-old male with a history of gunshot injury of the left shoulder 2006. Upon presentation in 2011, the patient had a loss of most of his shoulder bony and muscular structures...
August 31, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28874815/injectable-and-thermosensitive-tgf-%C3%AE-1-loaded-pcec-hydrogel-system-for-in-vivo-cartilage-repair
#10
Tengfei Zhou, Xiaolong Li, Guo Li, Taoran Tian, Shiyu Lin, Sirong Shi, Jinfeng Liao, Xiaoxiao Cai, Yunfeng Lin
Chondral defects pose a great challenge for clinicians to manage owing to the limited capacity for self-healing. Various traditional approaches have been adopted for the repair of these defects with unsatisfactory results. Cartilage tissue engineering techniques have emerged as promising strategies to enhance regeneration and overcome these traditional shortcomings. The cell-homing based technique is considered the most promising owing to its unique advantages. Thermosensitive hydrogels have been applied as scaffolds for biomedical applications with smart sol-gel response for altering environmental temperature...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28854503/the-utility-of-the-cognitive-function-instrument-cfi-to-detect-cognitive-decline-in-non-demented-older-adults
#11
Clara Li, Judith Neugroschl, Xiaodong Luo, Carolyn Zhu, Paul Aisen, Steven Ferris, Mary Sano
BACKGROUND: Subjective cognitive complaint is a sensitive marker of decline. OBJECTIVE: This study aimed to (1) examine reliability of subjective cognitive complaint using the Cognitive Function Instrument (CFI), and (2) assess the utility of the CFI to detect cognitive decline in non-demented elders. METHODS: Data from a four-year longitudinal study at multiple Alzheimer's Disease Cooperative Study (ADCS) sites were extracted (n = 644)...
August 21, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28843466/matriderm-decreases-donor-site-morbidity-after-radial-forearm-free-flap-harvest-in-transgender-surgery
#12
William Watfa, Pietro G di Summa, Joaquim Meuli, Wassim Raffoul, Olivier Bauquis
BACKGROUND: Phalloplasty with the radial forearm free flap is associated with a large donor site defect. AIM: To compare two methods of donor site closure for functional and cosmetic long-term results: full-thickness skin grafting vs split-thickness skin grafting with MatriDerm. METHODS: Thirty-seven transgender patients had a neophallus created from a radial forearm free flap, and all were operated on by the same senior surgeon. Eight patients had their donor site defect closed by total skin grafting and 29 patients, operated on after 2009, received a split-thickness skin graft with MatriDerm closure...
August 23, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28839405/comparative-alveolar-ridge-preservation-using-allogenous-tooth-graft-versus-free-dried-bone-allograft-a-randomized-controlled-prospective-clinical-pilot-study
#13
Chaitanya Pradeep Joshi, Cynthia Bernardo D'Lima, Urmila Chandrashekhar Samat, Prerna Ashok Karde, Agraja Ganpat Patil, Nitin Hemchandra Dani
BACKGROUND: For the first time in India, allografts from human extracted teeth were prepared. A randomized, prospective, clinicoradiographical, histological study was conducted to evaluate their efficacy in comparison with freeze-dried bone allograft (FDBA) in alveolar ridge preservation. MATERIALS AND METHODS: Graft preparation: with written consent, teeth were collected from three donors (full mouth extraction cases). Once donors' serums were tested negative for HIV, HBV, HCV, and Venereal disease research laboratory (VDRL), mineralized whole tooth allograft (WTA) and dentin allograft (DA) were prepared using the standard protocol of Tissue Bank at Tata Memorial Hospital, Mumbai, India...
April 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28839177/simple-md-based-model-for-oxidative-folding-of-peptides-and-proteins
#14
Sergei A Izmailov, Ivan S Podkorytov, Nikolai R Skrynnikov
Significant strides have been recently made to fold peptides and small proteins in silico using MD simulations. However, facilities are currently lacking to include disulfide bonding in the MD models of protein folding. To address this problem, we have developed a simple empirical protocol to model formation of disulfides, which is perturbation-free, retains the same speed as conventional MD simulations and allows one to control the reaction rate. The new protocol has been tested on 15-aminoacid peptide guanylin containing four cysteine residues; the net simulation time using Amber ff14SB force field was 61 μs...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827629/phellodendron-chinense-schneid-a-novel-yellow-emitting-luminescent-material-for-white-light-emitting-diodes
#15
Pin-Chun Lin, Kuei-Ting Hsu, Ming-Hsiu Shiu, Wei-Ren Liu
To facilitate the next generation of environmental material for white light emitting diodes, the discovery of natural luminesce is essential. In this study, we disclose a rare-earth free and yellow-emission phosphor, Phellodendron, which could be both excited by near ultraviolet light and blue light. The new yellow phosphor is obtained by extraction of Phellodendron chinense Schneid. The emission wavelength, full width at half maximum and CIE coordinates of extracted Phellodendron are 540 nm, 120 nm and (0...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28825789/multifunctional-analogs-of-kynurenic-acid-for-the-treatment-of-alzheimer-s-disease-synthesis-pharmacology-and-molecular-modeling-studies
#16
Girdhar Singh Deora, Srinivas Kantham, Stephen Chan, Satish N Dighe, Suresh K Veliyath, Gawain McColl, Marie-Odile Parat, Ross P McGeary, Benjamin P Ross
We report the synthesis and pharmacological investigation of analogs of the endogenous molecule kynurenic acid (KYNA) as multifunctional agents for the treatment of Alzheimer's disease (AD). Synthesized KYNA analogs were tested for their N-methyl-d-aspartate (NMDA) receptor binding, mGluR5 binding and function, acetylcholinesterase (AChE) inhibition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, interference with the amyloid β peptide (Aβ) fibrillation process, and protection against Aβ-induced toxicity in transgenic Caenorhabditis elegans strain GMC101 expressing full-length Aβ42...
September 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28816297/-perirenal-cystic-lymphangioma-in-an-adult-a-case-report-and-literature-review
#17
W He, Y C Hao, H Z Xia, R Z Ma, B Yang, J Lu
Lymphangioma is a rare, benign mesenchymal neoplasm, which is characterized by numerous intercommunicating cystic spaces containing lymphatic fluid. It is considered a congenital disease resulting from the obstruction of regional lymph drainage during the developmental period. Lymphangioma frequently occurs in the cervical neck and axilla, also in the retroperitoneum, mediastinum, mesentery, omentum, colon, and pelvis, rarely in the perirenal space. These tumors usually present in childhood, but infrequently, these also present in adults...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28811611/the-antibacterial-and-antifungal-activity-of-six-essential-oils-and-their-cyto-genotoxicity-to-human-hel-12469-cells
#18
Andrea Puškárová, Mária Bučková, Lucia Kraková, Domenico Pangallo, Katarína Kozics
Six essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. Antimicrobial activity was shown against pathogenic (Escherichia coli, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis) and environmental bacteria (Bacillus cereus, Arthrobacter protophormiae, Pseudomonas fragi) and fungi (Chaetomium globosum, Penicillium chrysogenum, Cladosporium cladosporoides, Alternaria alternata, and Aspergillus fumigatus)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806711/the-potential-of-an-automated-system-to-identify-the-upper-limb-component-of-a-controlled-sitting-posture
#19
María B Sánchez, Ian Loram, John Darby, Paul Holmes, Penelope B Butler
Full trunk control in sitting is demonstrated only when the head-trunk are aligned and upper limbs remain free of contact from mechanical support. These components represent a Controlled Kinetic Chain and can be evaluated in people with neuromotor disability using the Segmental Assessment of Trunk Control (SATCo) when a therapist provides manual trunk support at different segmental levels. However, the SATCo, as with other clinical assessments of control, is subjective. The SATCo was translated to objective rules relating the position of the hands and elbows to the head-trunk and then tested to determine the extent to which this automated objective method replicated the clinical judgement...
August 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28805733/first-detection-of-rotavirus-group-c-in-asymptomatic-pigs-of-smallholder-farms-in-east-africa
#20
Joshua Oluoch Amimo, Eunice Magoma Machuka, Edward Okoth
Abstract: Group C rotavirus (RVC) has been described to be a causative agent of gastroenteritis in humans and animals including pigs, cows, and dogs. Fecal samples collected from asymptomatic pigs in smallholder swine farms in Kenya and Uganda were screened for the presence of group C rotaviruses (RVC) using a reverse transcription-polymerase chain reaction assay. A total of 446 samples were tested and 37 were positive (8.3%). A significantly larger (p < 0.05) number of RVC-positive samples was detected in groups of older pigs (5-6 months) than in younger piglets (1-2 months)...
August 14, 2017: Pathogens
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