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https://www.readbyqxmd.com/read/28225850/the-influence-of-morphological-awareness-on-reading-and-writing-a-systematic-review
#1
Ainoã Athaide Macedo Silva, Vanessa de Oliveira Martins-Reis
Purpose: this study aimed to perform a systematic review of national and international studies about the relationship between morphological awareness, reading/writing, reading comprehension, and spelling. Research strategies: a search for national and international literature was carried out using databases Medline (via PubMed) and Portal de Periódicos da Capes (Eric, PsycINFO, LILACS, SciELO) from August to September 2015. Selection criteria: the inclusion criteria were: studies that answered the guiding question and addressed the subject matter established by the descriptors and keywords...
February 16, 2017: CoDAS
https://www.readbyqxmd.com/read/28224760/a-tree-parenchyma-coupled-model-for-lung-ventilation-simulation
#2
N Pozin, S Montesantos, I Katz, M Pichelin, I Vignon-Clementel, C Grandmont
In this article we develop a lung-ventilation model. The parenchyma is described as an elastic homogenized media. It is irrigated by a space-filling dyadic resistive pipe network, which represents the tracheo-bronchial tree. In this model the tree and the parenchyma are strongly coupled. The tree induces an extra viscous term in the system constitutive relation, which leads, in the finite element framework, to a full matrix. We consider an efficient algorithm that takes advantage of the tree structure to enable a fast matrix-vector product computation...
February 22, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28217425/short-term-effects-of-instrument-assisted-soft-tissue-mobilization-on-pain-free-range-of-motion-in-a-weightlifter-with-subacromial-pain-syndrome
#3
Joseph Paul Coviello, Rumit Singh Kakar, Timothy James Reynolds
BACKGROUND AND PURPOSE: While there is limited evidence supporting the use of soft tissue mobilization techniques for Subacromial Pain Syndrome (SAPS), synonymous with subacromial impingement syndrome, previous studies have reported successful outcomes using soft tissue mobilization as a treatment technique. The purpose of this case report is to document the results of Instrument-Assisted Soft Tissue Mobilization (IASTM) for the treatment of SAPS. CASE DESCRIPTION: Diagnosis was reached based on the subject's history, tenderness to palpation, and four out of five positive tests in the diagnostic cluster...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28212428/a-novel-hemagglutinin-protein-produced-in-bacteria-protects-chickens-against-h5n1-highly-pathogenic-avian-influenza-viruses-by-inducing-h5-subtype-specific-neutralizing-antibodies
#4
Violetta Sączyńska, Agnieszka Romanik, Katarzyna Florys, Violetta Cecuda-Adamczewska, Małgorzata Kęsik-Brodacka, Krzysztof Śmietanka, Monika Olszewska, Katarzyna Domańska-Blicharz, Zenon Minta, Bogusław Szewczyk, Grażyna Płucienniczak, Andrzej Płucienniczak
The highly pathogenic (HP) H5N1 avian influenza viruses (AIVs) cause a mortality rate of up to 100% in infected chickens and pose a permanent pandemic threat. Attempts to obtain effective vaccines against H5N1 HPAIVs have focused on hemagglutinin (HA), an immunodominant viral antigen capable of eliciting neutralizing antibodies. The vast majority of vaccine projects have been performed using eukaryotic expression systems. In contrast, we used a bacterial expression system to produce vaccine HA protein (bacterial HA) according to our own design...
2017: PloS One
https://www.readbyqxmd.com/read/28196063/long-term-results-and-recurrence-patterns-from-scope-1-a-phase-ii-iii-randomised-trial-of-definitive-chemoradiotherapy-cetuximab-in-oesophageal-cancer
#5
T Crosby, C N Hurt, S Falk, S Gollins, J Staffurth, R Ray, J A Bridgewater, J I Geh, D Cunningham, J Blazeby, R Roy, T Maughan, G Griffiths, S Mukherjee
BACKGROUND: The SCOPE-1 study tested the role of adding cetuximab to conventional definitive chemoradiotherapy (dCRT), and demonstrated greater toxicity and worse survival outcomes. We present the long-term outcomes and patterns of recurrence. METHODS: SCOPE-1 was a phase II/III trial in which patients were randomised to cisplatin 60 mg m(-2) (day 1) and capecitabine 625 mg m(-2) bd (days 1-21) for four cycles +/- cetuximab 400 mg m(-2) day 1 then by 250 mg m(-2) weekly...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28186717/gating-motions-and-stationary-gating-properties-of-ionotropic-glutamate-receptors-computation-meets-electrophysiology
#6
Huan-Xiang Zhou
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels essential to all aspects of brain function, including higher order processes such as learning and memory. For decades, electrophysiology was the primary means for characterizing the function of iGluRs and gaining mechanistic insight. Since the turn of the century, structures of isolated water-soluble domains and transmembrane-domain-containing constructs have provided the basis for formulating mechanistic hypotheses. Because these structures only represent sparse, often incomplete snapshots during iGluR activation, significant gaps in knowledge remain regarding structures, energetics, and dynamics of key substates along the functional processes...
February 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28182500/validity-of-various-methods-for-determining-velocity-force-and-power-in-the-back-squat
#7
Harry G Banyard, Ken Nosaka, Kimitake Sato, G Gregory Haff
PURPOSE: This investigation examined the validity of two kinematic systems for assessing mean velocity (MV), peak velocity (PV), mean force (MF), peak force (PF), mean power (MP), and peak power (PP) during the full depth free-weight back squat performed with maximal concentric effort. METHODS: Ten strength-trained men (26.1±3.0 y; 1.81±0.07 m; 82.0±10.6 kg) performed three 1-repetition maximum (1RM) trials on three separate days, encompassing lifts performed at six relative intensities including 20, 40, 60, 80, 90, and 100% of 1RM...
February 9, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28177570/studying-the-effect-of-physically-adsorbed-coating-polymers-on-the-cytotoxic-activity-of-optimized-bisdemethoxycurcumin-loaded-plga-nanoparticles
#8
Mina Mehanny, Rania M Hathout, Ahmed S Geneidi, Samar Mansour
The aim of this work was to study the effect of different physically-adsorbed coating polymers on the cytotoxic activity of optimized bisdemethoxycurcumin (BDMC) loaded-PLGA nanoparticles. BDMC-loaded PLGA nanoparticles were prepared adopting the nanoprecipitation technique according to a full factorial study design. The effects of three independent variables each at two levels, namely: the polymer type, polymer concentration and PVA concentration were studied. The particles were optimized regarding particle size and entrapment efficiency where sizes < 200 nm and entrapment efficiencies reaching ∼ 98% were obtained...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28176135/parallel-n-and-c-terminal-truncations-facilitate-purification-and-analysis-of-a-155-kda-cold-adapted-type-i-pullulanase
#9
Skander Elleuche, Alina Krull, Ute Lorenz, Garabed Antranikian
The cold-adapted pullulanase Pul13A is an industrial useful amylolytic enzyme, but its low solubility is the major bottleneck to produce the protein in recombinant form. In a previous approach, a complex and time-consuming purification strategy including a step-wise dialysis procedure using decreasing concentrations of urea to renature the insoluble protein from inclusion bodies had been established. In this study, a truncation strategy was developed to facilitate the purification and handling of the type-I pullulanase...
February 8, 2017: Protein Journal
https://www.readbyqxmd.com/read/28161725/treatment-for-residual-stones-using-flexible-ureteroscopy-and-holmium-laser-lithotripsy-after-the-management-of-complex-calculi-with-single-tract-percutaneous-nephrolithotomy
#10
L Chen, M-L Sha, D Li, J Zhuo, C-Y Jiang, Y-P Zhu, S-J Xia, J Lu, Y Shao
This study validated the effectiveness and safety of the treatment for residual stones using flexible ureteroscopy (fURS) and holmium laser (0.6-1.2 J, 20-30 Hz) lithotripsy via a fiber with a 200-μm core diameter and 0.22 numerical aperture (NA) after the management of complex calculi with single-tract percutaneous nephrolithotomy (PCNL). Between January 2014 and June 2016, 27 consecutive patients with complex calculi underwent fURS and holmium laser lithotripsy after a planned single-tract PCNL. Among the 27 patients with complex calculi, 9 had full staghorn calculi, 7 had partial staghorn calculi, and 11 had multiple calculi...
February 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28133881/towards-full-quantum-mechanics-based-protein-ligand-binding-affinities
#11
Stephan Ehrlich, Andreas H Göller, Stefan Grimme
Computational methods play a key role in modern drug design in pharmaceutical industry but are mostly based on force fields which are limited in accuracy when describing non-classical binding effects, proton transfer or metal coordination. Here, we propose a general fully quantum mechanical (QM) scheme for the computation of protein-ligand affinities. It works on a single protein cutout (of about 1000 atoms) and evaluates all contributions (interaction energy, solvation, thermostatistical) to absolute binding free energy on the highest feasible QM level...
January 29, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28133119/-a-case-of-large-rectal-villous-adenoma-associated-with-tenesmus-and-body-weight-loss
#12
Miho Okano, Masaki Okuyama, Masaya Nishino, Hiromitsu Hoshino, Junji Kawada, Yongkook Kim, Toshimasa Tsujinaka
The patient was a 78-year-old man who was hospitalized with a 1-month history of tenesmus and body weight loss. Blood tests revealed a mild increase in tumor markers(CEA 9.7 ng/mL)and an elevation of the inflammatory response. Colonoscopic examination disclosed a full circular lateral spreading tumor(LST)extending from the second Houston valve to the rectosigmoidal region with a more than 10 cm length. Since invasion to the SM layer was suspected, endoscopic resection was judged inapplicable and laparoscopic low anterior resection with D2 lymph node dissection was performed, along with covering ileostomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28114976/close-contact-interferon-gamma-response-to-the-new-psts1-285-374-cpf10-a-preliminary-1-year-follow-up-study
#13
Leonardo Silva de Araujo, Nidai de Bárbara Moreira da Silva Lins, Janaina Aparecida Medeiros Leung, Fernanda Carvalho Queiroz Mello, Maria Helena Féres Saad
BACKGROUND: The available diagnostic tools for latent tuberculosis (TB) infection (LTBI) via interferon-gamma (IFN-g) release assays (IGRA) are based on ESAT6:CFP10 stimulation. However, the mycobacterial antigen PstS1 is also highly immunogenic and some of its fragments, such as PstS1(285-374), have shown higher immunoreactivity in LTBI than in active TB. PstS1(285-374), therefore, could increase the accuracy of the existing IGRA to detect LTBI. Thus, a new chimeric protein has recently been developed (PstS1(285-374):CFP10) showing potential for LTBI screening of recent close contacts (rCt) exposed to Mycobacterium tuberculosis...
January 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28114012/ultrasonic-needles-for-bone-biopsy
#14
Andrew Mathieson, Robert Wallace, Rebecca Cleary, Li Li, Hamish Simpson, Margaret Lucas
Bone biopsy is an invasive clinical procedure where a bone sample is recovered for analysis during the diagnosis of a medical condition. When the architecture of the bone tissue is required to be preserved, a core-needle biopsy is taken. Although this procedure is performed while the patient is under local anaesthesia, the patient can still experience significant discomfort. Additionally, large haematoma can be induced in the soft tissue surrounding the biopsy site due to the large axial and rotational forces which are applied through the needle to penetrate bone...
December 7, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28104462/questionnaires-used-to-assess-barriers-of-clinical-guideline-use-among-physicians-are-not-comprehensive-reliable-or-valid-a-scoping-review
#15
REVIEW
Melina L Willson, Robin Wm Vernooij, Anna R Gagliardi
OBJECTIVE: This study described the number and characteristics of questionnaires used to assess barriers of guideline use among physicians. STUDY DESIGN: A scoping review was conducted. MEDLINE and EMBASE were searched from 2005 to June 2016. English language studies that administered a questionnaire to assess barriers of guideline use among practicing physicians were eligible. Summary statistics were used to report study and questionnaire characteristics. Questionnaire content was assessed with a checklist of 57 known barriers...
January 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28103990/-effects-of-human-amniotic-epithelial-stem-cells-derived-exosomes-on-healing-of-wound-with-full-thickness-skin-defect-in-rats
#16
B Zhao, G F Wu, Y J Zhang, W Zhang, F F Yang, D Xiao, K X Zeng, J H Shi, L L Su, D H Hu
Objective: To investigate the effects of human amniotic epithelial stem cells-derived exosomes on healing of wound with full-thickness skin defect in rats. Methods: (1) Human amniotic epithelial stem cells were isolated from the amnion tissue of 5 full-term pregnant women in Department of Obstetrics of our hospital by the method of trypsin digestion, and their morphology was observed. The third passage of cells were stained with rhodamine-phalloidin for cytoskeleton observation. The third passage of cells were identified with flow cytometry through the detection of expressions of cell surface markers CD29, CD31, CD34, CD90, CD105, SSEA3, SSEA4 and immunity-related marker human leukocyte antigen-D related site (HLA-DR)...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28095397/a-randomised-phase-ii-trial-and-feasibility-study-of-palliative-chemotherapy-in-frail-or-elderly-patients-with-advanced-gastroesophageal-cancer-321go
#17
P S Hall, S R Lord, M Collinson, H Marshall, M Jones, C Lowe, H Howard, D Swinson, G Velikova, A Anthoney, R Roy, J Dent, S Cheeseman, K Last, M T Seymour
BACKGROUND: Elderly patients are commonly under-represented in cancer clinical trials. The 321GO was undertaken in preparation for a definitive phase three trial assessing different chemotherapy regimens in a frail and/or elderly population with advanced gastroesophageal (GO) cancer. METHODS: Patients with advanced GO cancer considered unfit for conventional dose chemotherapy were randomly assigned in a 1 : 1 : 1 ratio to: epirubicin, oxaliplatin and capecitabine (EOX); oxaliplatin and capecitabine (OX); and capecitabine alone (X) (all 80% of full dose and unblinded)...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28089480/deep-inspiration-breath-hold-produces-a-clinically-meaningful-reduction-in-ipsilateral-lung-dose-during-locoregional-radiation-therapy-for-some-women-with-right-sided-breast-cancer
#18
Jessica L Conway, Leigh Conroy, Lindsay Harper, Marie Scheifele, Haocheng Li, Wendy L Smith, Tannis Graham, Tien Phan, Ivo A Olivotto
PURPOSE: The goal of the work described here was to determine whether deep inspiration breath-hold (DIBH) produces a clinically meaningful reduction in pulmonary dose compared with free breathing (FB) during locoregional radiation for right-sided breast cancer. METHODS AND MATERIALS: Four-field, modified-wide tangent plans with full nodal coverage were developed for 30 consecutive patients on paired DIBH and FB CT scans. Nodes were contoured according to European Society for Radiotherapy and Oncology guidelines...
October 19, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28077563/the-bioc-biogrid-corpus-full-text-articles-annotated-for-curation-of-protein-protein-and-genetic-interactions
#19
Rezarta Islamaj Doğan, Sun Kim, Andrew Chatr-Aryamontri, Christie S Chang, Rose Oughtred, Jennifer Rust, W John Wilbur, Donald C Comeau, Kara Dolinski, Mike Tyers
A great deal of information on the molecular genetics and biochemistry of model organisms has been reported in the scientific literature. However, this data is typically described in free text form and is not readily amenable to computational analyses. To this end, the BioGRID database systematically curates the biomedical literature for genetic and protein interaction data. This data is provided in a standardized computationally tractable format and includes structured annotation of experimental evidence. BioGRID curation necessarily involves substantial human effort by expert curators who must read each publication to extract the relevant information...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28071798/impact-of-rhizobial-inoculation-and-reduced-n-supply-on-biomass-production-and-biological-n2-fixation-in-common-bean-grown-hydroponically
#20
Charis-Konstantina Kontopoulou, Epifanios Liasis, Pietro P M Iannetta, Anastasia Tampakaki, Dimitrios Savvas
BACKGROUND: Testing rhizobial inoculation of common bean (Phaseolus vulgaris L.) in hydroponics enables accurate quantification of biological N2 -fixation (BNF) and provides information about the potential of reducing inorganic-N fertilizer use. In view of this background, common bean grown on pumice was inoculated with Rhizobium tropici CIAT899 (Rt) and supplied with either full-N (total-nitrogen 11.2 mM) or 1/3 of full-N, or N-free nutrient solution (NS). BNF was quantified at the early pod filling stage using the (15) N natural abundance method...
January 10, 2017: Journal of the Science of Food and Agriculture
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