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https://www.readbyqxmd.com/read/29316024/fully-automated-segmentation-of-the-left-ventricle-in-cine-cardiac-mri-using-neural-network-regression
#1
Li Kuo Tan, Robert A McLaughlin, Einly Lim, Yang Faridah Abdul Aziz, Yih Miin Liew
BACKGROUND: Left ventricle (LV) structure and functions are the primary assessment performed in most clinical cardiac MRI protocols. Fully automated LV segmentation might improve the efficiency and reproducibility of clinical assessment. PURPOSE: To develop and validate a fully automated neural network regression-based algorithm for segmentation of the LV in cardiac MRI, with full coverage from apex to base across all cardiac phases, utilizing both short axis (SA) and long axis (LA) scans...
January 9, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29313702/a-comparison-of-scaffold-free-and-scaffold-based-reconstructed-human-skin-models-as-alternatives-to-animal-use
#2
Beste Kinikoglu
Tissue engineered full-thickness human skin substitutes have various applications in the clinic and in the laboratory, such as in the treatment of burns or deep skin defects, and as reconstructed human skin models in the safety testing of drugs and cosmetics and in the fundamental study of skin biology and pathology. So far, different approaches have been proposed for the generation of reconstructed skin, each with its own advantages and disadvantages. Here, the classic tissue engineering approach, based on cell-seeded polymeric scaffolds, is compared with the less-studied cell self-assembly approach, where the cells are coaxed to synthesise their own extracellular matrix (ECM)...
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29304873/need-for-information-honesty-and-respect-patient-perspectives-on-health-care-professionals-communication-about-cancer-and-fertility
#3
Jane M Ussher, Chloe Parton, Janette Perz
BACKGROUND: Individuals affected by cancer report a need for information about fertility from health care professionals (HCPs), in order to inform decision making and alleviate anxiety. However, there is evidence that many health professionals do not engage in such discussions. METHOD: A mixed method design was used to examine the construction and subjective experience of communication with health professionals about fertility in the context of cancer, from the perspective of patients...
January 5, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29300787/plant-x-tender-an-extension-of-the-assemblx-system-for-the-assembly-and-expression-of-multigene-constructs-in-plants
#4
Tjaša Lukan, Fabian Machens, Anna Coll, Špela Baebler, Katrin Messerschmidt, Kristina Gruden
Cloning multiple DNA fragments for delivery of several genes of interest into the plant genome is one of the main technological challenges in plant synthetic biology. Despite several modular assembly methods developed in recent years, the plant biotechnology community has not widely adopted them yet, probably due to the lack of appropriate vectors and software tools. Here we present Plant X-tender, an extension of the highly efficient, scar-free and sequence-independent multigene assembly strategy AssemblX, based on overlap-depended cloning methods and rare-cutting restriction enzymes...
2018: PloS One
https://www.readbyqxmd.com/read/29300421/validity-of-the-self-mini-nutritional-assessment-self-mna-for-the-evaluation-of-nutritional-risk-a-cross-sectional-study-conducted-in-general-practice
#5
L M Donini, W Marrocco, C Marocco, A Lenzi
INTRODUCTION: Malnutrition is a frequent condition in the elderly especially in hospitals and in nursing homes, and even among the free-living elders the prevalence is not negligible (5-10%). Awareness towards malnutrition is still limited. The lack of time for nutritional assessment by the overcommitted healthcare personnel, including the general practitioners (GPs), may represent one possible explanation for limited recognition of malnutrition. Therefore, a self-administered instrument could be useful in raising alert on the GPs and allow early detection of malnutrition and early care provision...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29273024/is-unplanned-out-of-hospital-birth-managed-by-paramedics-infrequent-normal-and-uncomplicated
#6
Belinda Flanagan, Bill Lord, Margaret Barnes
BACKGROUND: Unplanned out-of-hospital birth is often perceived as precipitate in nature, 'infrequent', 'normal' and 'uncomplicated'. However, international studies report unplanned out-of-hospital birth is associated with increased rates of maternal and neonatal morbidity and mortality. This research describes intrapartum, immediate postpartum and neonatal care provided by paramedics in Queensland, Australia. The objectives were to (1) determine the number of cases where the paramedic documented birth or imminent birth during the study period (2) to describe the incidence of births prior to or during paramedic care (3) to detail any risk factors and/or complications recorded by paramedics during these cases, (4) identify paramedic pain management practices for intrapartum care, and (5) to examine the maternal and neonatal outcomes as documented by paramedics...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29261853/metal-free-materials-for-fixed-prosthodontic-restorations
#7
REVIEW
Carlo E Poggio, Carlo Ercoli, Lorena Rispoli, Carlo Maiorana, Marco Esposito
BACKGROUND: Fixed prosthodontic treatment (crowns, fixed dental prostheses (FDPs), complete arch prostheses) involves the use of several different materials to replace missing tooth structure. Traditionally full metal or metal frameworks veneered with ceramic (metal-ceramic (MC)) have been used. In recent years several different metal-free systems have become available to clinicians and patients. In general, metal-free restorations should allow practitioners to better reproduce natural tooth colour, avoiding shortcomings of MC restorations...
December 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29258474/full-title-peripheral-venous-catheter-complications-in-children-predisposing-factors-in-a-multicenter-prospective-cohort-study
#8
Rim Ben Abdelaziz, Habiba Hafsi, Hela Hajji, Hela Boudabous, Amel Ben Chehida, Ali Mrabet, Khadija Boussetta, Sihem Barsaoui, Azza Sammoud, Mourad Hamzaoui, Hatem Azzouz, Néji Tebib
BACKGROUND: Peripheral venous catheterization (PVC) is frequently used in children. This procedure is not free from potential complications. Our purpose was to identify the types and incidences of PVC complications in children and their predisposing factors in a developing country. METHODS: We conducted a prospective observational multicenter study in five pediatric and pediatric surgery departments over a period of 2 months. Two hundred fifteen PVC procedures were conducted in 98 children...
December 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29243293/the-association-between-celiac-disease-and-periodontitis-results-from-nhanes-2009-2012
#9
Thomas Spinell, Francesco DeMayo, Matthew Cato, Ashley Thai, Eva J Helmerhorst, Peter H R Green, Benjamin Lebwohl, Ryan T Demmer
AIM: To investigate whether celiac disease (CD) was associated with periodontitis among a nationally representative sample of U.S. adults. MATERIALS AND METHODS: The National Health and Nutrition Examination Survey (NHANES) 2009-2012 enrolled 6,661 subjects with full-mouth periodontal examination and serological testing for anti-tissue transglutaminase (tTg) and anti-endomysial (EMA) antibodies. CD was defined as i) self-reported physician diagnosis while on a gluten-free diet; ii) or tTg levels>10...
December 15, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29242713/electrochemical-disinfection-of-repeatedly-recycled-blackwater-in-a-free-standing-additive-free-toilet
#10
Brian T Hawkins, Katelyn L Sellgren, Ethan J D Klem, Jeffrey R Piascik, Brian R Stoner
Decentralized, energy-efficient waste water treatment technologies enabling water reuse are needed to sustainably address sanitation needs in water- and energy-scarce environments. Here, we describe the effects of repeated recycling of disinfected blackwater (as flush liquid) on the energy required to achieve full disinfection with an electrochemical process in a prototype toilet system. The recycled liquid rapidly reached a steady state with total solids reliably ranging between 0.50 and 0.65% and conductivity between 20 and 23 mS/cm through many flush cycles over 15 weeks...
November 2017: Water and Environment Journal: the Journal
https://www.readbyqxmd.com/read/29240734/transient-expression-of-human-antibodies-in-mammalian-cells
#11
Rodrigo Vazquez-Lombardi, Damien Nevoltris, Ansha Luthra, Peter Schofield, Carsten Zimmermann, Daniel Christ
Recombinant expression of antibody molecules in mammalian cells offers important advantages over traditionally utilized bacterial expression, including glycosylation required for antibody functionality and markedly reduced levels of endotoxin contamination. Advances in transient mammalian expression systems enable high yields (>100 mg/liter) that now allow for effective recombinant antibody production at a reasonable cost. Here, we provide step-by-step protocols for the design and recombinant expression of full-length IgG antibodies and antibody-derived constructs (including Fab, Fc-fusions and bispecifics) in mammalian cells...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29215139/a-novel-and-selective-nociceptin-receptor-nop-agonist-1-1-cis-4-isopropylcyclohexyl-piperidin-4-yl-1h-indol-2-yl-methanol-at-312-decreases-acquisition-of-ethanol-induced-conditioned-place-preference-in-mice
#12
Nurulain T Zaveri, Paul V Marquez, Michael E Meyer, Willma E Polgar, Abdul Hamid, Kabirullah Lutfy
BACKGROUND: Nociceptin/Orphanin FQ (N/OFQ), the endogenous peptide agonist for the opioid receptor-like (ORL1) receptor (also known as NOP or the nociceptin receptor), has been shown to block the acquisition and expression of ethanol-induced conditioned place preference (CPP). Here, we report the characterization of a novel small-molecule NOP ligand AT-312 (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol) in receptor binding and GTPγS functional assays in vitro...
December 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29213331/noninvasive-prenatal-diagnosis-of-fetal-aneuploidy-by-circulating-fetal-nucleated-red-blood-cells-and-extravillous-trophoblasts-using-silicon-based-nanostructured-microfluidics
#13
Chung-Er Huang, Gwo-Chin Ma, Hei-Jen Jou, Wen-Hsiang Lin, Dong-Jay Lee, Yi-Shing Lin, Norman A Ginsberg, Hsin-Fu Chen, Frank Mau-Chung Chang, Ming Chen
Background: Noninvasive prenatal testing (NIPT) based on cell-free DNA in maternal circulation has been accepted worldwide by the clinical community since 2011 but limitations, such as maternal malignancy and fetoplacental mosaicism, preclude its full replacement of invasive prenatal diagnosis. We present a novel silicon-based nanostructured microfluidics platform named as "Cell Reveal™" to demonstrate the feasibility of capturing circulating fetal nucleated red blood cells (fnRBC) and extravillous cytotrophoblasts (EVT) for cell-based noninvasive prenatal diagnosis (cbNIPD)...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29212734/predictors-of-response-and-survival-in-locally-advanced-adenocarcinoma-of-the-pancreas-following-neoadjuvant-gtx-with-or-without-radiation-therapy
#14
William H Sherman, Elizabeth Hecht, David Leung, Kyung Chu
LESSONS LEARNED: There is no presenting parameter that predicts the success of neoadjuvant therapy for pancreatic cancer.Despite the images on scans following neoadjuvant therapy, all patients should be evaluated, because inflammation following radiation therapy (RT) may overstate the extent of tumor and vascular involvement. BACKGROUND: In patients presenting with locally advanced pancreatic adenocarcinoma deemed unresectable by two pancreatic cancer surgeons, we analyzed presenting tumor size, extent of vascular involvement, tumor markers, response to neoadjuvant gemcitabine (G), docetaxel (T), and capecitabine (X) with or without additional chemoradiotherapy with GX on R0 resection rates (≥2 mm margins), and survival...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29210312/development-and-optimization-of-a-novel-drug-free-nanolipid-vesicular-system-for-treatment-of-osteoarthritis
#15
Mohamed S El Afify, Esmat A Zein El Dein, Bakheet E M Elsadek, Mostafa A Mohamed, Sanaa A El-Gizawy
Objective The goal of this study is to improve the transdermal delivery of phosphatidylcholine (PC) via constructing a novel nanolipid vesicular system (NLVS) with high level of permeability through the stratum corneum (SC). Significance In our study, a novel drug free NLVS was developed. The system depends on PC boundary cartilage lubrication to relieve osteoarthritic pain without developing gastrointestinal problems associated with anti-inflammatory drug. Materials and methods Full 23 factorial design is applied to optimize the quality of the prepared NLVS...
December 6, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29208688/the-impact-of-acute-bouts-of-interval-and-continuous-walking-on-energy-intake-and-appetite-regulation-in-subjects-with-type-2-diabetes
#16
Ida A Müller, Anne-Sophie Wedell-Neergaard, Thomas P J Solomon, Kristian Karstoft
In healthy subjects, it has been suggested that exercise may acutely suppress energy-intake and appetite, with peak intensity being an important determinant for this effect. In subjects with type 2 diabetes (T2D), the effect of exercise on appetite-related variables is, however, virtually unknown. We aimed to assess the effects of two exercise interventions, differing with regards to peak intensity, on energy-intake, satiety and appetite-related hormones in subjects with T2D. Thirteen subjects with T2D completed three 60-min interventions with continuous measurement of oxygen consumption in a randomized and counterbalanced order: (1) Control, (2) Continuous walking (CW; intended 73% of VO2peak), (3) Interval-walking (IW; repeated cycles of 3 min slow [54% of VO2peak] and 3 min fast walking [89% of VO2peak])...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29206639/electrical-impedance-tomography-in-children-with-community-acquired-pneumonia-preliminary-data
#17
Marta B Mazzoni, Alessandra Perri, Anna M Plebani, Silvia Ferrari, Giacomo Amelio, Alessia Rocchi, Dario Consonni, Gregorio P Milani, Emilio F Fossali
BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive pulmonary function test that provides spatial and temporal information of changes in regional lung ventilation. We aimed to assess the feasibility of EIT as a supplementary tool in the evaluation of community acquired pneumonia in children. Furthermore, we performed a prospective evaluation of regional lung ventilation changes during a six-month follow-up period. METHODS: We enrolled otherwise healthy children aged 2-15 years with radiological diagnosis of community acquired pneumonia on admission at pediatric emergency department...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29190512/free-nitrous-acid-pre-treatment-of-waste-activated-sludge-enhances-volatile-solids-destruction-and-improves-sludge-dewaterability-in-continuous-anaerobic-digestion
#18
Wei Wei, Qilin Wang, Liguo Zhang, Andrew Laloo, Haoran Duan, Damien J Batstone, Zhiguo Yuan
Previous work has demonstrated that pre-treatment of waste activated sludge (WAS) with free nitrous acid (FNA i.e. HNO2) enhances the biodegradability of WAS, identified by a 20-50% increase in specific methane production in biochemical methane potential (BMP) tests. This suggests that FNA pre-treatment would enhance the destruction of volatile solids (VS) in an anaerobic sludge digester, and reduce overall sludge disposal costs, provided that the dewaterability of the digested sludge is not negatively affected...
November 24, 2017: Water Research
https://www.readbyqxmd.com/read/29185909/the-effects-of-a-neutral-cosolute-on-the-b-to-z-transition-for-dna-duplexes-incorporating-both-cg-and-ca-steps
#19
Pakinee Phromsiri, Rebecca R Gerling, Joshua M Blose
In the cell, nearly 40% of the volume is occupied by macromolecular crowding agents and smaller osmolytes accumulate in response to environmental stresses. Of particular interest is the influence of osmolytes on the transition of the right-handed B-DNA to the left-handed Z-DNA. Due to the correlation between Z-DNA formation potential and regions of active transcription, Z-DNA is believed to serve a vital role in the transcription process, and changes in osmolyte concentration may influence transcription as a part of the stress response...
November 29, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29181261/functional-outcomes-of-hip-arthroscopy-in-an-active-duty-military-population-utilizing-a-criterion-based-early-weight-bearing-progression
#20
K Aaron Shaw, Jeremy M Jacobs, J Richard Evanson, Josh Pniewski, Michelle L Dickston, Terry Mueller, John A Bojescul
Introduction: Hip arthroscopy allows surgeons to address intra-articular pathology of the hip while avoiding more invasive open surgical dislocation. However the post-operative rehabilitation protocols have varied greatly in the literature, with many having prolonged periods of limited motion and weight bearing. Purpose: The purpose of this study was to describe a criterion-based early weight bearing protocol following hip arthroscopy and investigate functional outcomes in the subjects who were active duty military...
October 2017: International Journal of Sports Physical Therapy
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