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https://www.readbyqxmd.com/read/28426465/neoadjuvant-treatment-a-novel-standard
#1
Sandro Pasquali, Elena Palassini, Silvia Stacchiotti, Paolo G Casali, Alessandro Gronchi
PURPOSE OF REVIEW: The aim of this study was to summarize developments in the adjuvant/neoadjuvant chemotherapy of high-risk adult-type soft tissue sarcomas (STS). RECENT FINDINGS: The role of adjuvant/neaodjuvant chemotherapy in these patients is controversial, with a meta-analysis suggesting a 10% survival benefit. Recently, a randomized controlled trial in high-risk STS of extremities and trunk wall showed a 20% improvement in progression-free and overall survival after three preoperative cycles of epirubicin along with ifosfamide compared with a histology-tailored chemotherapy...
April 19, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28421600/lay-led-and-peer-support-interventions-for-adolescents-with-asthma
#2
REVIEW
Kayleigh M Kew, Robin Carr, Iain Crossingham
BACKGROUND: Adolescents with asthma are at high risk of poor adherence with treatment. This may be compounded by activities that worsen asthma, in particular smoking. Additional support above and beyond routine care has the potential to encourage good self-management. We wanted to find out whether sessions led by their peers or by lay leaders help to reduce these risks and improve asthma outcomes among adolescents. OBJECTIVES: To assess the safety and efficacy of lay-led and peer support interventions for adolescents with asthma...
April 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28418590/control-of-biofouling-by-xanthine-oxidase-on-seawater-reverse-osmosis-membranes-from-a-desalination-plant-enzyme-production-and-screening-of-bacterial-isolates-from-the-full-scale-plant
#3
Veena Nagaraj, Lucy Skillman, Dan Li, Zhangwang Xie, Goen Ho
Control of biofouling on seawater reverse osmosis (SWRO) membranes is a major challenge as treatments can be expensive, damage the membrane material and often biocides do not remove the polymers in which bacteria are embedded. Biological control has been largely ignored for biofouling control. The objective of this study was to demonstrate the effectiveness of xanthine oxidase enzyme against complex fouling communities and then identify naturally occurring bacterial strains that produce the free radical generating enzyme...
April 18, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28414765/validation-of-full-field-optical-coherence-tomography-in-distinguishing-malignant-and-benign-tissue-in-resected-pancreatic-cancer-specimens
#4
Labrinus van Manen, Paulien L Stegehuis, Arantza Fariña-Sarasqueta, Lorraine M de Haan, Jeroen Eggermont, Bert A Bonsing, Hans Morreau, Boudewijn P F Lelieveldt, Cornelis J H van de Velde, Alexander L Vahrmeijer, Jouke Dijkstra, J Sven D Mieog
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related mortality in the United States. The minority of patients can undergo curative-intended surgical therapy due to progressive disease stage at time of diagnosis. Nonetheless, tumor involvement of surgical margins is seen in up to 70% of resections, being a strong negative prognostic factor. Real-time intraoperative imaging modalities may aid surgeons to obtain tumor-free resection margins. Full-field optical coherence tomography (FF-OCT) is a promising diagnostic tool using high-resolution white-light interference microscopy without tissue processing...
2017: PloS One
https://www.readbyqxmd.com/read/28412431/3d-morphological-changes-in-lv-and-rv-during-lvad-ramp-studies
#5
Karima Addetia, Nir Uriel, Francesco Maffessanti, Gabriel Sayer, Sirtaz Adatya, Gene H Kim, Nitasha Sarswat, Savitri Fedson, Diego Medvedofsky, Eric Kruse, Keith Collins, Daniel Rodgers, Takayoshi Ota, Valluvan Jeevanandam, Victor Mor-Avi, Daniel Burkhoff, Roberto M Lang
OBJECTIVES: The purpose of this study was to investigate the differential impact of the 2 most commonly available left ventricular assist device (LVAD) types on the right (RV) and left (LV) ventricles using 3-dimensional (3D) echocardiography-based analysis of ventricular morphology. BACKGROUND: LVADs have emerged as common therapy for advanced heart failure. Recent data suggest that the heart responds differently to speed settings in the 2 main devices available (HeartMate II [HMII], St Jude Medical, Pleasanton, California, and HVAD, HeartWare International, Framingham, Massachusetts)...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28410350/education-socioeconomic-status-and-intelligence-in-childhood-and-stroke-risk-in-later-life-a-meta-analysis
#6
Caroline A McHutchison, Ellen V Backhouse, Vera Cvoro, Susan D Shenkin, Joanna M Wardlaw
BACKGROUND: Stroke is the second most common cause of death, and a common cause of dependency and dementia. Adult vascular risk factors and socioeconomic status (SES) are associated with increased risk, but less is known about early life risk factors, such as education, childhood SES, or intelligence (IQ). METHODS: We comprehensively searched Medline, PsycINFO and EMBASE from inception to November 2015. We included all studies reporting data on >50 strokes examining childhood/premorbid IQ, SES, and education...
April 7, 2017: Epidemiology
https://www.readbyqxmd.com/read/28400314/peg-pe-clay-composite-carriers-for-doxorubicin-effect-of-composite-structure-on-release-cell-interaction-and-cytotoxicity
#7
Hagay Kohay, Can Sarisozen, Rupa Sawant, Aditi Jhaveri, Vladimir P Torchilin, Yael G Mishael
A novel drug delivery system for doxorubicin (DOX), based on organic-inorganic composites was developed. DOX was incorporated in micelles (M-DOX) of polyethylene glycol-phosphatidylethanolamine (PEG-PE) which in turn were adsorbed by the clay, montmorillonite (MMT). The nano-structures of the PEG-PE/MMT composites of LOW and HIGH polymer loadings were characterized by XRD, TGA, FTIR, size (DLS) and zeta measurements. These measurements suggest that for the LOW composite a single layer of polymer intercalates in the clay platelets and the polymer only partially covers the external surface, while for the HIGH composite two layers of polymer intercalate and a bilayer may form on the external surface...
April 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28388454/initial-steps-to-inform-selection-of-continuation-cognitive-therapy-or-fluoxetine-for-higher-risk-responders-to-cognitive-therapy-for-recurrent-major-depressive-disorder
#8
Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase, Robin B Jarrett
Responders to acute-phase cognitive therapy (A-CT) for major depressive disorder (MDD) often relapse or recur, but continuation-phase cognitive therapy (C-CT) or fluoxetine reduces risks for some patients. We tested composite moderators of C-CT versus fluoxetine's preventive effects to inform continuation treatment selection. Responders to A-CT for MDD judged to be at higher risk for relapse due to unstable or partial remission (N=172) were randomized to 8 months of C-CT or fluoxetine with clinical management and assessed, free from protocol treatment, for 24 additional months...
March 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28380953/compact-see-through-3d-head-mounted-display-based-on-wavefront-modulation-with-holographic-grating-filter
#9
Qiankun Gao, Juan Liu, Xinhui Duan, Tao Zhao, Xin Li, Peilin Liu
A compact see-through three-dimensional head-mounted display (3D-HMD) is proposed and investigated in this paper. Two phase holograms are analytically extracted from the object wavefront and uploaded on different zones of the spatial light modulator (SLM). A holographic grating is further used as the frequency filter to couple the separated holograms together for wavefront modulation. The developed preliminary prototype has a simple optical facility and a compact structure (133.8mm × 40.4mm × 35.4mm with a 47...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28379118/on-the-forming-mechanism-of-the-cleaning-airflow-of-pulse-jet-fabric-filters
#10
Cai Jiying, Hao Wenge, Zhang Cong, Yu Jiaqi, Wang Ting
To reveal the formation mechanism of a pulse-jet airflow's cleaning effect in a filter bag, a theoretical model is built by using the theory of gas jet and unitary adiabatic flow according to given specifications and dimensions of the bags and resistance characteristics of the cloth and dust layer. It is about the relationship between cleaning system structure and operating parameters. The model follows the principle that the flow and kinetic energy of jet flow injected into a filter bag should be consistent with the flow of cleaning airflow in the bag and the pressure drop flowing through the filter cloth and dust layer...
April 5, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28374754/model-independent-particle-species-disentanglement-by-x-ray-cross-correlation-scattering
#11
B Pedrini, A Menzel, V A Guzenko, C David, R Abela, C Gutt
Mixtures of different particle species are often investigated using the angular averages of the scattered X-ray intensity. The number of species is deduced by singular value decomposition methods. The full disentanglement of the data into per-species contributions requires additional knowledge about the system under investigation. We propose to exploit higher-order angular X-ray intensity correlations with a new computational protocol, which we apply to synchrotron data from two-species mixtures of two-dimensional static test nanoparticles...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374304/septum-enhanced-mammaplasty-in-inferocentral-pedicled-breast-reduction-for-macromastia-and-gigantomastia-patients
#12
Aurelio Portincasa, Francesco Ciancio, Luigi Cagiano, Alessandro Innocenti, Domenico Parisi
BACKGROUND: Inferior pedicle and free nipple grafting are commonly used as breast reduction techniques for patients with breast hypertrophy and gigantomastia. Limitations of these techniques are, respectively, possible vascular compromise and total/partial necrosis of the nipple-areola complex (NAC). The authors describe the innovative inferocentral pedicled reduction mammaplasty (ICPBR) enhanced by preservation of Würinger's septum for severe hypertrophic breasts. MATERIALS AND METHODS: Among 287 breast reductions performed between January 2001 and 2015, 83 (28...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28371541/an-engineered-cell-instructive-stroma-for-the-fabrication-of-a-novel-full-thickness-human-cervix-equivalent-in-vitro
#13
Vincenza De Gregorio, Giorgia Imparato, Francesco Urciuolo, Maria L Tornesello, Clorinda Annunziata, Franco M Buonaguro, Paolo A Netti
There is a growing interest for developing organotypic cervical models by using primary cervical cells that are able to reproduce the physiological relevant stromal microenvironment and the distinctive histology of the native cervical epithelium. Here for the first time it is reported the production of an organotypic cervical model featured by a scaffold-free stromal tissue resembling the extracellular matrix (ECM) composition and organization of the native counterpart as well as a completely well-differentiated epithelium...
March 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28366657/normal-porcine-ureter-retains-lumen-wall-integrity-but-not-patency-following-catheter-directed-irreversible-electroporation-imaging-and-histologic-assessment-over-28-days
#14
Govindarajan Srimathveeravalli, Francois Cornelis, Thomas Wimmer, Sebastien Monette, Simon Y Kimm, Majid Maybody, Stephen B Solomon, Jonathan A Coleman, Jeremy C Durack
PURPOSE: To evaluate the effect of catheter-directed irreversible electroporation (IRE) on the integrity, patency, and function of the normal porcine ureter. MATERIALS AND METHODS: A catheter-mounted electrode was used to perform fluoroscopy-guided IRE in 8 healthy pigs. Two unilateral ablations (90 pulses at 2,000 V, 100 μs) were performed in each animal in the proximal and distal ureter. Serum creatinine measurements and contrast-enhanced computed tomography imaging were performed at 1, 7, 14, 21, and 28 days after IRE, and findings were compared with baseline values by Student t test...
March 30, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28361875/label-free-quantification-of-calcium-sensor-targeting-to-photoreceptor-guanylate-cyclase-and-rhodopsin-kinase-by-backscattering-interferometry
#15
Stefan Sulmann, Amanda Kussrow, Darryl J Bornhop, Karl-Wilhelm Koch
Quantification of protein binding to membrane proteins is challenging and a limited set of methods is available to study such systems. Here we employed backscattering interferometry (BSI), a free-solution label-free method with high sensitivity, to quantify the interaction of neuronal Ca(2+)-Sensor proteins with their targets operating in phototransduction. We tested direct binding of guanylate cyclase-activating proteins (GCAP1 and GCAP2) to their membrane target guanylate cyclase 1. The regulatory mechanism of GCAPs including their binding interface in the target is unresolved...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28356432/the-inflammatory-potential-of-the-diet-is-associated-with-depressive-symptoms-in-different-subgroups-of-the-general-population
#16
Moufidath Adjibade, Valentina A Andreeva, Cédric Lemogne, Mathilde Touvier, Nitin Shivappa, James R Hébert, Michael D Wirth, Serge Hercberg, Pilar Galan, Chantal Julia, Karen E Assmann, Emmanuelle Kesse-Guyot
Background: Low-grade chronic inflammation, which can be modulated by diet, has been suggested as an important risk factor for depression, but few studies have investigated the association between the inflammatory potential of the diet and depression.Objective: We investigated the prospective association between the inflammatory potential of the diet, measured by the Dietary Inflammatory Index (DII), and incident depressive symptoms and tested the potential modulating effect of sex, age, physical activity, and smoking status...
March 29, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28340762/reference-free-spectroscopic-determination-of-fat-and-protein-in-milk-in-the-visible-and-near-infrared-region-below-1000nm-using-spatially-resolved-diffuse-reflectance-fiber-probe
#17
Andrey Bogomolov, Valeria Belikova, Vladislav Galyanin, Anastasiia Melenteva, Hans Meyer
New technique of diffuse reflectance spectroscopic analysis of milk fat and total protein content in the visible (Vis) and adjacent near infrared (NIR) region (400-995nm) has been developed and tested. Sample analysis was performed through a probe having eight 200-µm fiber channels forming a linear array. One of the end fibers was used for the illumination and other seven - for the spectroscopic detection of diffusely reflected light. One of the detection channels was used as a reference to normalize the spectra and to convert them into absorbance-equivalent units...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28334653/the-impact-of-transitions-in-insurance-coverage-on-gp-visiting-among-children-in-ireland
#18
Anne Nolan, Richard Layte
The use of direct out-of-pocket payments to finance general practitioner (GP) care by the majority of the population in Ireland is unusual in a European context. Currently, approximately 40 per cent of the population have means-tested access to free GP care, while the remainder must pay the full out-of-pocket cost. In this paper, we use nationally representative data from the Growing up in Ireland (GUI) study to examine the impact of transitions in insurance coverage on GP utilisation among children. GUI surveys two cohorts of nearly 20,000 children (aged 9 months and 9 years at baseline); we use data from the first two waves of each cohort (which covers the period 2007-2012)...
May 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28333653/association-of-transient-hyperthyroidism-and-severity-of-hyperemesis-gravidarum
#19
Nor Zila Hassan Malek, Aida Kalok, Zainal Abidin Hanafiah, Shamsul Azhar Shah, Nor Azlin Mohamed Ismail
Background Transient non-immune hyperthyroidism in early pregnancy is hyperthyroidism diagnosed for the first time in early pregnancy, without evidence of thyroid autoimmunity or clinical findings of Grave's disease and resolved spontaneously as the pregnancy progressed. Hyperemesis gravidarum (HG) is the commonest cause with 66%-73% of women with severe HG were found to have elevated thyroid function. Materials and methods We conducted a cross sectional study to determine the prevalence of transient hyperthyroidism in patients with hyperemesis gravidarum and its relation to the severity of nausea and vomiting...
March 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28325542/the-influence-of-ethnicity-and-glucose-tolerance-status-on-subjective-hunger-sensations-and-prospective-food-intake-in-overweight-and-obese-asian-and-european-australians
#20
Leilani Muhardi, Yun Zhao, Vicky Solah, Susan Fyfe, Mario J Soares
AIMS: To examine the influence of ethnicity and glucose tolerance status on subjective sensations and food intake in overweight/obese Asian and European Australians. METHODS: 18 Asians and 26 Europids were classified as normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) based on serial measures of finger-prick glucose following an oral glucose tolerance test (OGTT). Subjective sensations of hunger and satiety were measured before and every 15min after the OGTT using a visual analogue scale (VAS)...
March 6, 2017: Diabetes & Metabolic Syndrome
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