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https://www.readbyqxmd.com/read/28811240/changes-in-mucosal-and-serum-immunoglobulin-levels-of-california-sea-lions-during-early-development
#1
W Espinosa-de Aquino, M Bailey, K Acevedo-Whitehouse
To date, most studies on pinniped immunoglobulins have focused on circulating antibodies. However, systemic and local immune activities differ in terms of maturation, intensity, and types of effectors that participate. Here, we examined levels of three immunoglobulin isotypes, IgG, IgM and IgA, in the blood and mucosal membranes of free-living California sea lion pups. We investigated whether age, body condition and sex influenced their concentration. Isotype levels varied among tissues, with age-related patterns that could be indicative of differential regulation along development...
August 12, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28783897/gonadal-intersex-in-smallmouth-bass-micropterus-dolomieu-from-northern-indiana-with-correlations-to-molecular-biomarkers-and-anthropogenic-chemicals
#2
Ahmed Abdel-Moneim, Daragh Deegan, Jiejun Gao, Chloe De Perre, Jarrod S Doucette, Byron Jenkinson, Linda Lee, Maria S Sepúlveda
Over the past decade, studies have shown that exposure to endocrine disrupting chemicals (EDCs) can cause gonadal intersex in fish. Smallmouth bass (Micropterus dolomieu) males appear to be highly susceptible to developing testicular oocytes (TO), the most prevalent form of gonadal intersex, as observed in various areas across the U.S. In this study, prevalence and severity of TO was quantified for smallmouth bass sampled from the St. Joseph River in northern Indiana, intersex biomarkers were developed, and association between TO prevalence and organic contaminants were explored...
July 31, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28760664/effect-of-11%C3%AE-hydroxyandrostenedione-on-european-whitefish-coregonus-lavaretus-linnaeus-1758
#3
Jarosław Król, Piotr Hliwa, Adam Polewacz, Agnieszka Stabińska, Stefan Dobosz, Konrad Ocalewicz
The goal of the present research was to evaluate the efficiency of 11β-hydroxyandrostenedione (OHA) applied in the diet to achieve sex reversal in the European whitefish (Coregonus lavaretus). At 32day post-hatching, fish were reared in four groups: fish fed with 10ppm of OHA (10 OHA), fish fed with 20ppm of OHA (20 OHA), fish fed without OHA (C) and fish fed without OHA and reared in the water from 20 OHA group (R). The experimental groups were conducted in separate recirculation systems and the first phase of the experiment lasted 63days...
July 25, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28756588/trace-element-concentrations-in-livers-of-common-buzzards-buteo-buteo-from-eastern-poland
#4
Ignacy Kitowski, Dariusz Jakubas, Dariusz Wiącek, Agnieszka Sujak, Grzegorz Pitucha
In this study, our aim was to determine the common sources of origin of 18 elements in the livers of Common Buzzards collected during the breeding season in an extensive agricultural landscape in south-east Poland with respect to age (adults and immatures) and sex (males and females). In all 34 specimens collected, the element concentrations followed the pattern of S > Na > Fe > Mg > Zn > Si > Cu > Mn > Ba > Se > B > Pb > Hg > Cd > Cr > Ni > Sr > V. Among the heavy metals examined, only the concentration of Pb was relatively high...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28728528/between-concealing-and-revealing-intersexed-bodies-parental-strategies
#5
Limor Meoded Danon, Anike Krämer
Parents of intersex children are perceived in many studies as hopeless, highly dependent on the medical system, and as gate keepers of normative gendered bodies. In this article, we challenge these perceptions and argue that parents of intersex children are problematically positioned between their children's needs for care and well-being and the socialmedical forces that aim to "normalize" them. Their in-between position leads them to establish different parental strategies within and outside of traditional sex/gender norms...
August 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28723306/inclusion-of-lesbian-gay-bisexual-transgender-queer-and-intersex-health-in-australian-and-new-zealand-medical-education
#6
Asiel Adan Sanchez, Erica Southgate, Gary Rogers, Robbert J Duvivier
PURPOSE: This study aims at establishing the scope of lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) health in Australian and New Zealand medical curricula. METHODS: We sent medical school curriculum administrators an online cross-sectional survey. RESULTS: The response rate was 15 medical schools (71%): 14 Australian schools and 1 New Zealand school. Respondents included program directors (n = 5; 33%), course coordinators (n = 4; 27%), Heads of School (n = 2; 13%), one Dean (7%), and three others (20%)...
August 2017: LGBT Health
https://www.readbyqxmd.com/read/28712604/-sometimes-you-feel-like-the-freak-show-a%C3%A2-qualitative-assessment-of-emergency-care-experiences-among-transgender-and-gender-nonconforming-patients
#7
Elizabeth A Samuels, Chantal Tape, Naomi Garber, Sarah Bowman, Esther K Choo
STUDY OBJECTIVE: Transgender, gender-variant, and intersex (trans) people have decreased access to care and poorer health outcomes compared with the general population. Little has been studied and documented about such patients' emergency department (ED) experiences and barriers to care. Using survey and qualitative research methods, this study aims to identify specific areas for improvement and generate testable hypotheses about the barriers and challenges for trans individuals needing acute care...
July 13, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28622991/transcription-of-ribogenesis-genes-in-fish-gonads-applications-in-the-identification-of-stages-of-oogenesis-and-in-environmental-monitoring-of-intersex-condition
#8
Iratxe Rojo-Bartolomé, Ainara Valencia, Ibon Cancio
One of the best described effects of environmental xenoestrogens in fish is the generation of intersex gonads in males. Considering 5S rRNA a marker of the presence of oocytes, a 5S/18S rRNA index was calculated in 296 thicklip grey mullets (Chelon labrosus) from polluted environments. In addition, qPCR analysis of transcription factors gtf3a and ubtf1, related respectively to 5S and 18S rRNA synthesis, was conducted along female-oogenesis. 5S/18S rRNA index identified sex with a threshold value of 0.4521 separating males from females...
June 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28602421/endocrine-disruption-effects-in-male-and-intersex-roach-rutilus-rutilus-l-from-french-rivers-an-integrative-approach-based-on-subcellular-to-individual-responses
#9
Perrine Geraudie, Marie Gerbron, Christophe Minier
Among the chemicals found in the aquatic environment, some have been reported to interact with the endocrine system of organisms and have been identified as endocrine disrupting compounds. In this study, we have assessed the biological effects due to environmental estrogenic compounds in adult male roach (Rutilus rutilus). Wild fish were collected in the Seine River, and one of its affluent, the Epte River in Normandy, France and impacts on endocrine and reproductive functions have been assessed. This study provides innovative data on the intersex condition in wild fish that are crucial to understand estrogenic contamination impacts and maintenance of sustainable fish population...
June 6, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28589012/-they-will-be-afraid-to-touch-you-lgbti-people-and-sex-workers-experiences-of-accessing-healthcare-in-zimbabwe-an-in-depth-qualitative-study
#10
Jennifer Hunt, Katherine Bristowe, Sybille Chidyamatare, Richard Harding
OBJECTIVES: To examine experiences of key populations (lesbian, gay, bisexual, trans and intersex (LGBTI) people, men who have sex with men (MSM) and sex workers) in Zimbabwe regarding access to, and experiences of, healthcare. DESIGN: Qualitative study using in-depth interviews and focus groups, with thematic analysis. PARTICIPANTS: Sixty individuals from key populations in Zimbabwe. SETTING: Participants were recruited from four locations (Harare, Bulawayo, Mutare, Beitbridge/Masvingo)...
March 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28574671/interdisciplinary-care-in-disorders-differences-of-sex-development-dsd-the-psychosocial-component-of-the-dsd-translational-research-network
#11
David E Sandberg, Melissa Gardner, Nina Callens, Tom Mazur
Scientific discovery and clinical management strategies for Disorders/Differences of Sex Development (DSD) have advanced in recent years. The 2006 Consensus Statement on Management of Intersex Disorders stated that a mental health component to care is integral to promote positive adaptation, yet the parameters of this element have not been described. The objective of this paper is threefold: to describe the psychosocial screening protocol adopted by the clinical centers of the DSD-Translational Research Network; to summarize psychosocial data collected at 1 of the 10 network sites; and to suggest how systematic behavioral health screenings can be employed to tailor care in DSD that results in better health and quality of life outcomes...
June 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28545802/attitudes-towards-disorders-of-sex-development-nomenclature-among-affected-individuals
#12
Emilie K Johnson, Ilina Rosoklija, Courtney Finlayson, Diane Chen, Elizabeth B Yerkes, Mary Beth Madonna, Jane L Holl, Arlene B Baratz, Georgiann Davis, Earl Y Cheng
INTRODUCTION: Although now commonly used in medicine, the updated "disorders of sex development" (DSD) nomenclature formally introduced in 2006 has never been universally accepted by members of the affected community, particularly advocacy groups. Use of this nomenclature by medical professionals may unintentionally negatively affect access to healthcare and research for individuals with DSD conditions. OBJECTIVE: Among individuals affected by various DSD diagnoses, this study sought to (1) evaluate attitudes towards potentially controversial DSD terminology, (2) determine potential impact of terminology on how affected individuals access healthcare, and (3) explore alternate terms...
May 8, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28535943/pragmatic-approach-to-intersex-including-genital-ambiguity-in-the-newborn
#13
Kanthi Bangalore Krishna, Christopher P Houk, Peter A Lee
The evaluation and management of a newborn with ambiguous genitalia must be undertaken as quickly as possible and with great sensitivity for the child's family. Where possible, a comprehensive team approach with a pediatric urologist, endocrinologist, geneticist, neonatologist, and child psychiatrist/psychologist should work closely with the family to establish the diagnosis and determine gender. Although the preferred gender assignment is not always clear, a thorough examination of endocrine function, karyotype, and potential for fertility should guide the determination...
June 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28534684/observed-deficiencies-in-medical-student-knowledge-of-transgender-and-intersex-health
#14
Jennifer J Liang, Ivy H Gardner, Jacob A Walker, Joshua D Safer
BACKGROUND: Lesbian, gay, bisexual, transgender, and intersex (LGBTI) patients face many well-documented disparities in care which among transgender and intersex people can often be traced to providers' lack of knowledge. METHODS: We administered surveys to examine the self-assessed knowledge and attitudes of all medical students at Boston University regarding different LGBTI subpopulations. Survey questions were based on a Likert scale from 1-5; analysis was conducted with Wilcoxon rank sum test...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28523454/stigma-associated-with-classical-congenital-adrenal-hyperplasia-in-women-s-sexual-lives
#15
Heino F L Meyer-Bahlburg, Jananne Khuri, Jazmin Reyes-Portillo, Anke A Ehrhardt, Maria I New
The risk of intersex-related stigma often serves as social indication for "corrective" genital surgery, but has not been comprehensively documented. In preparation for the development of an intersex-specific stigma assessment tool, this qualitative project aimed to explore stigma in girls and women with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. As part of a comprehensive follow-up project, 62 adult women with classical CAH (age range 18-51 years) took part in an open-ended retrospective interview focusing on the impact of CAH and its treatment on various aspects of girls' and women's lives...
May 18, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28481724/what-lesbian-gay-bisexual-transgender-queer-and-intersex-patients-say-doctors-should-know-and-do-a-qualitative-study
#16
Alison B Alpert, Eileen M CichoskiKelly, Aaron D Fox
This qualitative study explored the experiences of lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) people in health care and their recommendations for physicians. Six focus groups were conducted with LGBTQI people (N = 48) in four U.S. cities between October 2013 and April 2014. Five overarching themes emerged regarding patients' suggestions for providers: be comfortable with LGBTQI patients; share medical decision-making; avoid assumptions; apply LGBTQI-related knowledge; and address the social context of health disparities...
2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28411869/detection-of-endocrine-disrupting-chemicals-and-evidence-of-their-effects-on-the-hpg-axis-of-the-european-anchovy-engraulis-encrasicolus
#17
Andrea Miccoli, Francesca Maradonna, Andrea De Felice, Vincenzo Caputo Barucchi, Andone Estonba, Michele Genangeli, Sauro Vittori, Iole Leonori, Oliana Carnevali
Natural/synthetic Endocrine Disrupting Chemicals (EDCs) may display estrogenic activity and a lower potency than 17β-estradiol. Nonetheless, their concentrations and additive effects can affect the endocrine system and reproductive processes related to the Hypothalamic-Pituitary-Gonadal (HPG) axis. Because of their persistence in both the environment and biological systems, they ultimately target multi-level predators, including humans. We detected presence and effects of xenobiotics on wild anchovy Engraulis encrasicolus in the Western Adriatic Sea...
June 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28399716/the-lgbtqi-health-forum-an-innovative-interprofessional-initiative-to-support-curriculum-reform
#18
Hannan M Braun, David Ramirez, Greg J Zahner, Eva Mae Gillis-Buck, Heather Sheriff, Marcus Ferrone
Lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) individuals continue to face barriers to accessing appropriate and comprehensive healthcare. Compounding this problem, healthcare trainees report few training opportunities and low levels of preparedness to care for LGBTQI patients. In 2009, an interprofessional group of students and a faculty advisor at the University of California, San Francisco, developed a novel student-organized LGBTQI Health Forum for medical, dental, pharmacy, nursing, and physical therapy students to deliver LGBTQI health content that was otherwise absent from the formal curriculum...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28341464/reproductive-effects-of-oestrogenic-endocrine-disrupting-chemicals-in-astyanax-rivularis-inhabiting-headwaters-of-the-velhas-river-brazil
#19
André Alberto Weber, Davidson Peruci Moreira, Rafael Magno Costa Melo, Augusto Bicalho Cruz Vieira, Paula Suzanna Prado, Mirra Angelina Neres da Silva, Nilo Bazzoli, Elizete Rizzo
The Velhas River is the most polluted river in the state of Minas Gerais, south-eastern Brazil. Due to its historical and environmental relevance, the aim of this study was to evaluate the effects of oestrogenic endocrine disruptors on the reproduction of the lambari Astyanax rivularis, a small-sized species found in headwaters of the São Francisco River basin. Quarterly field samplings were carried out during a reproductive cycle in three streams of the upper Velhas River: S1 (reference site) and S2 and S3 (sites contaminated by untreated sewage)...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28325592/intersexuality-in-aquatic-invertebrates-prevalence-and-causes
#20
REVIEW
Tiago F Grilo, Rui Rosa
This review is the first assembling information on intersexuality in aquatic invertebrates, from freshwater to estuarine and marine environments. Intersex is a condition whereby an individual of a gonochorist (separate sexes) species has oocytes or distinct stages of spermatogonia, at varying degrees of development, within the normal gonad of the opposite gender (i.e. spermatocytes in the ovary or oocytes in the testis), often involving alterations in the gonadal structure, reproductive tract or external genitalia...
March 18, 2017: Science of the Total Environment
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