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Yu Shi, Wenguang Liu, Maoxian He
Bivalve mollusks exhibit hermaphroditism and sex reversal/differentiation. Studies generally focus on transcriptional profiling and specific genes related to sex determination and differentiation. Few studies on sex reversal/differentiation have been reported. A combination analysis of gonad proteomics and transcriptomics was conducted on Chlamys nobilis to provide a systematic understanding of sex reversal/differentiation in bivalves. We obtained 4258 unique peptides and 93,731 unigenes with good correlation between messenger RNA and protein levels...
March 15, 2018: Marine Biotechnology
A A Makhrov, V S Artamonova, O V Kolmakova, M V Ponomareva
This article is devoted to presenting the hypothesis explaining the fact of a considerable prevalence of phenotypic males among the triploid pink salmon as well as the regular occurrence of intersexes, which were revealed by us. This hypothesis also explains the large proportion (in some cases) in pink salmon populations of the individuals whose genetic sex does not match the phenotypic sex. We assume that the genes encoding the factors that contribute to the transformation of individuals into males (but not the marker sequences of the Y chromosome) are present not only in the Y chromosome of pink salmon but also in the X chromosome, although in smaller quantities...
January 2018: Doklady. Biochemistry and Biophysics
John W Honour, E Conway, R Hodkinson, F Lam
The metabolites of cortisol, and the intermediates in the pathways from cholesterol to cortisol and the adrenal sex steroids can be analysed in a single separation of steroids by gas chromatography (GC) coupled to MS to give a urinary steroid profile (USP). Steroids individually and in profile are now commonly measured in plasma by liquid chromatography (LC) coupled with MS/MS. The steroid conjugates in urine can be determined after hydrolysis and derivative formation and for the first time without hydrolysis using GC-MS, GC-MS/MS and liquid chromatography with mass spectrometry (LC-MS/MS)...
February 23, 2018: Journal of Steroid Biochemistry and Molecular Biology
Brian W Pence, Jon C Mills, Angela M Bengtson, Bradley N Gaynes, Tiffany L Breger, Robert L Cook, Richard D Moore, David J Grelotti, Conall O'Cleirigh, Michael J Mugavero
Importance: Depression commonly affects adults with HIV and complicates the management of HIV. Depression among individuals with HIV tends to be chronic and cyclical, but the association of this chronicity with HIV outcomes (and the related potential for screening and intervention to shorten depressive episodes) has received little attention. Objective: To examine the association between increased chronicity of depression and multiple HIV care continuum indicators (HIV appointment attendance, treatment failure, and mortality)...
February 21, 2018: JAMA Psychiatry
David Andrew Griffiths
The 2006 'Consensus statement on management of intersex disorders' recommended moving to a new classification of intersex variations, framed in terms of 'disorders of sex development' or DSD. Part of the rationale for this change was to move away from associations with gender, and to increase clarity by grounding the classification system in genetics. While the medical community has largely accepted the move, some individuals from intersex activist communities have condemned it. In addition, people both inside and outside the medical community have disagreed about what should be covered by the classification system, in particular whether sex chromosome variations and the related diagnoses of Turner and Klinefelter's syndromes should be included...
February 2018: Social Studies of Science
Paula Gaudenzi
This study proposes to reflect on the links between knowledge production and its daily effects on the field of sexuality, based on intersexuality as a contemporary issue. Intersexuality is an interesting object of analysis for such reflection, since it allows exploring the interfaces between knowledge production on sexuality, power relations between professionals, intersex persons, and their families, use of embodiment technologies, conceptions of the normal and natural body, formation of subjectivities, and the shaping of a new social, political, and moral order heavily associated with subjects' biological constitution...
February 5, 2018: Cadernos de Saúde Pública
Kiran Pienaar, Dean A Murphy, Kane Race, Toby Lea
It is well-established that a high prevalence of substance use is found in lesbian, gay, bisexual, transgender, intersex and queer (LGBTIQ) populations; a finding that researchers attribute to the stigmatised status of non-normative sexual and gender expression, and the role of illicit drug use in the collective production of socio-sexual pleasures, expressivity and disclosure in LGBTIQ communities. Despite the connections between sexual experimentation and substance use, LGBTIQ consumption practices have rarely received the attention they deserve within the alcohol and other drug (AOD) field...
January 24, 2018: International Journal on Drug Policy
Daniel Romo-Mendoza, Rafael Campos-Ramos, Grecia Vázquez-Islas, Mario A Burgos-Aceves, Edgar R Esquivel-Gutiérrez, Danitzia A Guerrero-Tortolero
Social factors and aromatase gene expression in the leopard grouper Mycteroperca rosacea was studied when captive fish were separated by sex during the reproductive (April-June) and post-reproductive (July-September) seasons. Monosex females, monosex males, and mixed-sex, held in social sextet units were analyzed for sex steroids throughout confinement. At the end of the experiment, the gonad-sex was defined by histology, and gonad and brain aromatase gene expressions were quantified. Only males held in the monosex social units changed sex...
January 18, 2018: General and Comparative Endocrinology
Sam Rowlands, Jean-Jacques Amy
BACKGROUND: The bodies of some transgender and intersex people have been mutilated and their minds subjected to immense distress. Their gender has often been determined by others. Loss of fertility used to be considered an inevitable consequence of treatment. OBJECTIVE: To review the issue of preserving the reproductive potential of transgender and intersex people. METHODS: A narrative review based on a wide-ranging search of the literature in multiple disciplines...
January 11, 2018: European Journal of Contraception & Reproductive Health Care
David A Klein, Erin N Berry-Bibee, Kristin Keglovitz Baker, Nikita M Malcolm, Julia M Rollison, Brittni N Frederiksen
OBJECTIVE: Lesbian, gay, bisexual, transgender, queer/questioning, intersex and asexual (LGBTQIA) individuals have unique sexual and reproductive health needs; however, facilitators and barriers to optimal care are largely understudied. The objective of this study was to synthesize findings from a systematic review of the literature regarding the provision of quality family planning services to LGBTQIA clients to inform clinical and research strategies. STUDY DESIGN: Sixteen electronic bibliographic databases (e...
January 5, 2018: Contraception
Nicholas J Niemuth, Rebecca D Klaper
The presence of intersex fish in watersheds around the world is a warning of the presence of anthropogenic endocrine-disrupting compounds (EDCs) being deposited into the aquatic environment. The anti-diabetic drug metformin is among the most prevalent and ubiquitous of the myriad pharmaceuticals found in wastewater effluent and watersheds worldwide. In addition to its prescription for type-2 diabetes, metformin is indicated as a treatment in cancers and the endocrine disorder polycystic ovarian syndrome (PCOS)...
December 8, 2017: Aquatic Toxicology
David O Norris, Ashley L Bolden, Alan M Vajda
Gonads were examined visually and histologically from white sucker (Catostomus commersoni) and fathead minnows (Pimephales promelas) isolated from museum specimens collected from Boulder Creek, Colorado. These fishes were collected between 42 and 102 years ago before addition of large quantities of estrogenic chemicals via wastewater effluent was reported to disrupt reproductive structures and functions in white suckers living in Boulder Creek downstream of the wastewater treatment facility (WWTF) and in test exposures of fathead minnows to wastewater effluent at the WWTF...
December 2, 2017: General and Comparative Endocrinology
Corey L Campbell, Laura B Dickson, Saul Lozano-Fuentes, Punita Juneja, Francis M Jiggins, William C Black
BACKGROUND: Some populations of West African Aedes aegypti, the dengue and zika vector, are reproductively incompatible; our earlier study showed that divergence and rearrangements of genes on chromosome 1, which bears the sex locus (M), may be involved. We also previously described a proposed cryptic subspecies SenAae (PK10, Senegal) that had many more high inter-sex FST genes on chromosome 1 than did Ae.aegypti aegypti (Aaa, Pai Lom, Thailand). The current work more thoroughly explores the significance of those findings...
December 4, 2017: BMC Genomics
Elizabeth Reis, Samuel Reis-Dennis
There's no doubt that reproductive technologies can transform lives for the better. Infertile couples and single, lesbian, gay, intersex, and transgender people have the potential to form families in ways that would have been inconceivable years ago. Yet we are concerned about the widespread commercialization of certain egg-freezing programs, the messages they propagate about motherhood, the way they blur the line between care and experimentation, and the manipulative and exaggerated marketing that stretches the truth and inspires false hope in women of various ages...
December 2017: Hastings Center Report
Tara M Prairie, Bethany Wrye, Sarah Murfree
The purpose of this study is to explore the ways that some health care providers perceive the intersectionality of their autonomy, religious faith, and their medical practice, specifically when it comes to providing care for the LGBT+ (lesbian, gay, bisexual, transgender, queer, intersex, and asexual) community. Physicians (n = 25) and medical residents (n = 17) located in the southeast completed a qualitative survey regarding their views of working with LGBT+ patients. Five main themes resulted from the analysis: adequate education, communication, discrimination, duty versus physician autonomy, and religious exemption...
November 1, 2017: Health Promotion Practice
Sara D Cardoso, David Gonçalves, Alexander Goesmann, Adelino V M Canário, Rui F Oliveira
Distinct patterns of gene expression often underlie intra- and intersexual differences, and the study of this set of coregulated genes is essential to understand the emergence of complex behavioural phenotypes. Here, we describe the development of a de novo transcriptome and brain gene expression profiles of wild-caught peacock blenny, Salaria pavo, an intertidal fish with sex-role reversal in courtship behaviour (i.e., females are the courting sex) and sequential alternative reproductive tactics in males (i...
November 7, 2017: Molecular Ecology
Jane E Morthorst, Karsten K Mathiesen, Henrik Holbech, Knud L Pedersen, Poul Bjerregaard
Feminization of male and juvenile fish caused by exposure to estrogens or estrogenic chemicals in effluents from central wastewater treatment plants (WWTP) is a worldwide issue of concern. Intersex and induction of the female yolk protein, vitellogenin, in male and juvenile fish are robust biomarkers for estrogenic exposure, and feminized fish have been observed downstream WWTP outlets in many countries. Danish central WWTPs reduce effluent estrogenicity effectively by advanced sewage treatment, and feminizations have not been observed downstream central WWTP outlets...
October 27, 2017: Environmental Toxicology and Chemistry
Kangwan Fongkaew, Anoporn Khruataeng, Sumon Unsathit, Matawii Khamphiirathasana, Nisarat Jongwisan, Oranong Arlunaek, Jensen Byrne
This article presents an analysis of news reports containing information or opinions about lesbian, gay, bisexual, transgender, intersex, and queer (LGBTIQ) people taken from six Thai media outlets over a period of one year. The aim was to explore how LGBTIQ people are portrayed in news media narratives. LGBTIQ identities were found to be vastly underrepresented and, when represented, were often represented inaccurately, stereotypically, harmfully, or without a clear understanding of the diversity of sexual orientations, gender identities, and gender expressions...
October 26, 2017: Journal of Homosexuality
Johanna Viau-Colindres, Marni Axelrad, Lefkothea P Karaviti
No abstract text is available yet for this article.
November 2017: Pediatrics
Colleen Cartwright, Ben White, Lindy Willmott, Malcolm Parker, Gail Williams
In most developed countries, competent patients have the legal right to refuse any medical treatment; Advance Care Planning mechanisms extend this right to non-competent patients. However, some groups, including lesbian, gay, bisexual, transgender and intersex (LGBTI) people, risk their wishes not being respected if they lose capacity, more than others. Little is known about medical practitioners' knowledge of, or attitudes to, the law in this area, especially in relation to LGBTI people, or how the law influences their decision-making...
October 25, 2017: Culture, Health & Sexuality
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