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https://www.readbyqxmd.com/read/28075104/esophageal-cancer
#1
Matthew W Short, Kristina G Burgers, Vincent T Fry
Esophageal cancer has a poor prognosis and high mortality rate, with an estimated 16,910 new cases and 15,910 deaths projected in 2016 in the United States. Squamous cell carcinoma and adenocarcinoma account for more than 95% of esophageal cancers. Squamous cell carcinoma is more common in nonindustrialized countries, and important risk factors include smoking, alcohol use, and achalasia. Adenocarcinoma is the predominant esophageal cancer in developed nations, and important risk factors include chronic gastroesophageal reflux disease, obesity, and smoking...
January 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28072725/laparoscopic-revision-surgery-for-gastroesophageal-reflux-disease
#2
Haydar Celasin, Volkan Genc, Suleyman Utku Celik, Ahmet Gökhan Turkcapar
Laparoscopic antireflux surgery is a frequently performed procedure for the treatment of gastroesophageal reflux in surgical clinics. Reflux can recur in between 3% and 30% of patients on whom antireflux surgery has been performed, and so revision surgery can be required due to recurrent symptoms or dysphagia in approximately 3% to 6% of the patients. The objective of this study is to evaluate the mechanism of recurrences after antireflux surgery and to share our results after revision surgery in recurrent cases...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28061013/esophagogastric-junction-contractile-integral-and-morphology-two-high-resolution-manometry-metrics-of-the-anti-reflux-barrier
#3
Hyoju Ham, Y U Kyung Cho, Han Hee Lee, Seung Bae Yoon, Chul-Hyun Lim, Jin Su Kim, Jae Myung Park, Myung-Gyu Choi
AIMS: We evaluated associations of esophagogastric junction (EGJ) metrics as an anti-reflux barrier with impedance-pH, endoscopic esophagitis, and lower esophageal sphincter (LES) metrics. METHODS: We reviewed high resolution manometry data from consecutive patients with GERD symptoms who underwent impedance-pH and endoscopy, and asymptomatic volunteers. The EGJ contractile integral (CI) was calculated as the mean contractile integral/second during three respiratory cycles...
January 6, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28052291/yogurt-containing-lactobacillus-gasseri-mitigates-aspirin-induced-small-bowel-injuries-a-prospective-randomized-double-blind-placebo-controlled-trial
#4
Takayoshi Suzuki, Aya Masui, Jun Nakamura, Hirokazu Shiozawa, Jun Aoki, Hirohiko Nakae, Shingo Tsuda, Jin Imai, Ozawa Hideki, Masashi Matsushima, Tetsuya Mine, Akira Tamura, Toshihiro Ohtsu, Yukio Asami, Atsushi Takagi
BACKGROUND: Although there is evidence about the beneficial effects of probiotics, their effects on aspirin-induced small bowel injuries have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri OLL2716 (LG) on aspirin-induced small intestinal lesions, such as ulcers, erosions, reddened lesions, and bleeding. SUMMARY: This study enrolled 64 patients who received aspirin for more than 1 month and provided written informed consent to be part of the study...
2017: Digestion
https://www.readbyqxmd.com/read/28040500/a-modification-of-nissen-fundoplication-improves-patients-outcome-and-may-reduce-procedure-related-failure-rate
#5
Romeo Bardini, Sabrina Rampado, Renato Salvador, Lisa Zanatta, Imerio Angriman, Silvia Degasperi, Angelica Ganss, Edoardo Savarino
BACKGROUND: Laparoscopic anti-reflux surgery has a failure rate of 10-20%. We aimed to investigate whether a modification of Nissen fundoplication (MNF) may improve patients' outcome and reduce failure rate. MATERIALS & METHODS: We prospectively compared 40 consecutive patients with gastroesophageal reflux disease who underwent anti-reflux surgery: 20 Nissen fundoplication (NF) and 20 the MNF approach. Eight cases in the MNF group needed redo surgery. The MNF consisted in suturing the esophagus to the diaphragmatic crura on each side by means of 4 non-absorbable stitches and in fixing the upper stitch of the valve to diaphragm...
December 28, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28028956/assessment-of-clinical-symptoms-and-multichannel-intraluminal-impedance-and-ph-monitoring-in-children-after-thoracoscopic-repair-of-esophageal-atresia-and-distal-tracheoesophageal-fistula
#6
Barbara M Iwańczak, Agnieszka Kosmowska-Miśków, Anna Kofla-Dłubacz, Mateusz Palczewski, Michał Grabiński, Katarzyna Pawłowska, Krzysztof Matusiewicz, Dariusz Patkowski
BACKGROUND: Motility disturbances of the esophagus and gastroesophageal reflux disease (GERD) are observed frequently in children after repair of congenital esophageal atresia with distal tracheoesophageal fistula (EA/TEF). Recently, in many pediatric surgical centers, thoracoscopic repair was introduced, which theoretically would change the postoperative course. OBJECTIVES: The goal of the study was to assess physical development, disease symptoms, and GERD symptom frequency in children who underwent thoracoscopic surgery of congenital EA/TEF...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028499/barrett-s-mucosa-segmentation-in-endoscopic-images-using-a-hybrid-method-spatial-fuzzy-c-mean-and-level-set
#7
Hossein Yousefi-Banaem, Hossein Rabbani, Peyman Adibi
Barrett's mucosa is one of the most important diseases in upper gastrointestinal system that caused by gastro-esophagus reflux. If left untreated, the disease will cause distal esophagus and gastric cardia adenocarcinoma. The malignancy risk is very high in short segment Barrett's mucosa. Therefore, lesion area segmentation can improve specialist decision for treatment. In this paper, we proposed a combined fuzzy method with active models for Barrett's mucosa segmentation. In this study, we applied three methods for special area segmentation and determination...
October 2016: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28028458/risk-of-lung-cancer-in-patients-with-gastro-esophageal-reflux-disease-a-population-based-cohort-study
#8
Chi-Kuei Hsu, Chih-Cheng Lai, Kun Wang, Likwang Chen
This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < ...
2016: PeerJ
https://www.readbyqxmd.com/read/27995468/alpha-fetoprotein-producing-esophageal-adenocarcinoma-a-mimicker-of-hepatocellular-carcinoma
#9
Jeremy Wang, Wendy Liu, Keyur Parikh, Anthony Benjamin Post
Alpha-fetoprotein (AFP)-producing esophageal adenocarcinoma (EAC) is a rare occurrence. Elevation of serum AFP is commonly associated with hepatocellular carcinoma and yolk sac tumors, but rarely with esophageal carcinoma. Here, we report a rare case of AFP-producing EAC. A 51-year-old man presented with two weeks of acid reflux and a 35-lb weight loss. Laboratory data were notable for transaminitis and AFP was 2524 ng/mL. Computed tomography of the abdomen revealed abnormal thickening of the esophagus and multiple metastatic masses throughout the liver...
December 19, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27994270/esophageal-transit-scintigraphy-in-systemic-sclerosis
#10
REVIEW
Marek Chojnowski, Małgorzata Kobylecka, Marzena Olesińska
Systemic sclerosis is a rare connective tissue disease, distinctive features of which are fibrosis and microangiopathy. The esophagus is one of the most commonly involved internal organs. Most patients experience dysphagia, difficulties in swallowing and gastro-esophageal reflux. However, in up to one third of cases, the initial onset of esophageal disease may be clinically silent. There are several diagnostic modalities available for assessing both morphological and functional abnormalities of the esophagus...
2016: Reumatologia
https://www.readbyqxmd.com/read/27993699/gastroesophageal-mucosal-injury-after-cholecystectomy-an-indication-for-surveillance
#11
Syeda Nadia Shah Gilani, Gary Alan Bass, Natallia Kharytaniuk, Michelle R Downes, Emer Frances Caffrey, Iqbal Tobbia, Thomas Noel Walsh
BACKGROUND: Cholecystectomy alters bile release dynamics from pulsatile meal-stimulated to continuous, and results in retrograde duodeno-gastric bile reflux(DGR). Bile is implicated in mucosal injury following gastric surgery, but whether cholecystectomy causes esophago-gastric mucosal inflammation, thus increasing the risk of metaplasia, is unclear. STUDY DESIGN: This study examined whether cholecystectomy-induced DGR promotes chronic inflammatory mucosal changes of the stomach and/or at the esophago-gastric junction(EGJ)...
December 16, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27984348/low-impedance-baseline-values-predict-severe-esophagitis
#12
Judith Cohen Sabban, Gabriela Donato Bertoldi, Federico Ussher, Silvia Christiansen, Carlos Lifschitz, Marina Orsi
OBJETIVES: To determine if esophageal baseline impedance (BI) values in children could be predictive of esophagitis. MATERIAL & METHODS: Multichannel intraluminal Impedance (MII) tracings of children 3 to 17 yrs of age suspected of having gastroesophageal reflux (GER) and esophagitis, who had also undergone upper endoscopy with multiple esophageal biopsies, were reviewed. Patients with eosinophilic esophagitis were excluded. Esophagitis was assessed by macroscopic and microscopic parameters...
December 15, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27979581/the-edematous-and-erythematous-airway-does-not-denote-pathologic-gastroesophageal-reflux
#13
Rachel Rosen, Paul D Mitchell, Janine Amirault, Manali Amin, Karen Watters, Reza Rahbar
OBJECTIVE: To determine if the reflux finding score (RFS), a validated score for airway inflammation, correlates with gastroesophageal reflux measured by multichannel intraluminal impedance (MII) testing, endoscopy, and quality of life scores. STUDY DESIGN: We performed a prospective, cross-sectional cohort study of 77 children with chronic cough undergoing direct laryngoscopy and bronchoscopy, esophagogastroduodenoscopy, and MII testing with pH (pH-MII) between 2006 and 2011...
December 13, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27979389/eosinophilic-esophagitis-update-in-diagnosis-and-management-position-paper-by-the-italian-society-of-gastroenterology-and-gastrointestinal-endoscopy-sige
#14
REVIEW
Nicola de Bortoli, Roberto Penagini, Edoardo Savarino, Santino Marchi
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized by symptoms related to esophageal dysfunction, as well as significant esophageal eosinophilia. The entity exists worldwide but has been most extensively studied in Western countries. However, a wide range of symptoms has been noticed such as chest pain or gastro-esophageal reflux disease-like symptoms. Upper gastro-intestinal endoscopy and esophageal biopsies are crucial for the diagnosis. Endoscopy might be normal or reveal typical patterns such as rings, furrows, exudates, edema, and stricture...
December 2, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27973922/minimal-differences-in-prevalence-and-spectrum-of-organic-disease-at-upper-gastrointestinal-endoscopy-between-selected-secondary-care-patients-with-symptoms-of-gastro-oesophageal-reflux-or-dyspepsia
#15
Andrew J Irvine, Maria Ines Pinto-Sanchez, Premysl Bercik, Paul Moayyedi, Alexander C Ford
OBJECTIVES: Gastro-oesophageal reflux and dyspepsia are felt to be separate upper gastrointestinal (GI) conditions. We aimed to measure the degree of overlap between them, and assess whether endoscopic findings differed. MATERIAL AND METHODS: Demographic, symptom, upper GI endoscopy and histology data were collected from consecutive adults in secondary care. Patients were categorised according to whether they reported gastro-oesophageal reflux alone, dyspepsia alone or both, and patient demographics and endoscopic findings were compared...
December 15, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27966065/conversion-of-an-open-salmon-s-technique-to-a-laparoscopic-gastric-bypass
#16
Cristina Rihuete-Caro, Débora Acín-Gandara, Manuel Medina-García, Santiago Alonso-Gómez, Alfonso Antequera-Pérez, Lucía Carrión-Álvarez, Fernando Pereira-Pérez
BACKGROUND: There are a growing number of patients who require revisional bariatric surgery due to the failure of their primary procedures. The aim of this video is to present a laparoscopic revisional procedure for dysphagia and gastroesophageal reflux disease (GERD) after an uncommonly performed bariatric surgery, Salmon's technique, consisting of a vertical banded gastroplasty and a horizontal stomach stapling with a Roux-en-Y bypass. METHODS: A 42-year-old obese male, with a history of dyslipidemia and a current body mass index (BMI) of 33, presented with severe dysphagia to solids and frequent spitting 10 years after the primary bariatric surgery (Salmon's procedure) with a BMI of 43...
February 2017: Obesity Surgery
https://www.readbyqxmd.com/read/27957783/russian-caucasians-have-a-higher-risk-of-erosive-reflux-disease-compared-with-east-asians-a-direct-endoscopic-comparison
#17
S-H Ko, M K Baeg, H S Jung, P Kim, M-G Choi
BACKGROUND: Erosive reflux disease (ERD) is prevalent in the West, and its incidence is increasing in the East. The differences between the West and East, especially in body composition, have not been investigated thoroughly. METHODS: Subjects who underwent esophagogastroduodenoscopy and body composition analysis during health screening were analyzed retrospectively. Russian Caucasians who visited Korea were propensity matched with native Koreans. Endoscopy results were analyzed to identify ERD and gastroesophageal flap valve (GEFV) status...
December 12, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27957292/the-effect-of-zinc-supplementationon-the-symptoms-of-gastroesophageal-reflux-disease-a-randomized-clinical-trial
#18
Afshin Shafaghi, Jalal Hasanzadeh, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Maryam Yaseri
BACKGROUND Currently, it has been demonstrated that gastroesophageal reflux disease (GERD) is one of the most important disorders of the digestive system and the commixture of regular diet has a significant influence on its incidence, symptoms, and prognosis. The purpose of this study was to evaluate the effect of zinc supplementation, in combination with PPIs(Proton pump inhibitors), on the improvement of GERD symptoms. METHODS In a randomized double blind clinical trial, patients with reflux symptoms, who had obtained Reflux Disease Questionnaire (RDQ) score more than 8, were included and all the demographic features were recorded...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27933133/pre-operative-clinical-and-instrumental-factors-as-antireflux-surgery-outcome-predictors
#19
REVIEW
Salvatore Tolone, Giorgia Gualtieri, Edoardo Savarino, Marzio Frazzoni, Nicola de Bortoli, Manuele Furnari, Giuseppina Casalino, Simona Parisi, Vincenzo Savarino, Ludovico Docimo
Gastroesophageal reflux disease (GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors (PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD...
November 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27931636/complications-of-submucosal-endoscopy
#20
REVIEW
Jean-Michel Gonzalez, Alban Benezech, Marc Barthet
Submucosal endoscopy essentially regroups peroral endoscopic esophageal myotomy (POEM) and, more recently, pyloromyotomy and tunnel tumor resections. The complication rate of POEM is between 5% and 10%. Complications include gas-related complications, mucosal tears, and bleeding, and are usually managed conservatively or with non-surgical procedures. Only one case of death has been reported. The most commonly identified risk factors for complicated procedures in POEM are short experience with the technique and sigmoid-type esophagus...
October 2016: Best Practice & Research. Clinical Gastroenterology
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