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dodecanoic acid

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https://www.readbyqxmd.com/read/28370710/probing-skin-physiology-through-the-volatile-footprint-discriminating-volatile-emissions-before-and-after-acute-barrier-disruption
#1
Emer Duffy, Matthew R Jacobs, Brian Kirby, Aoife Morrin
Volatile organic compounds emitted by human skin were sampled before and after acute barrier disruption of the volar forearm to investigate the significance of this approach to skin physiology research. A small wearable housing integrating a solid phase micro-extraction fibre permitting rapid enclosed headspace sampling of human skin volatiles is presented, enabling non-invasive sample collection in 15 minutes, in a comfortable wearable format. Gas chromatography-mass spectrometry was utilised to separate and identify the volatile metabolites...
March 31, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28264464/chemical-composition-in-vitro-antimicrobial-free-radical-scavenging-and-antioxidant-activities-of-the-essential-oil-of-leucas-inflata-benth
#2
Ramzi A Mothana, Omar M Noman, Ebtesam S Al-Sheddi, Jamal M Khaled, Mansour S Al-Said, Adnan J Al-Rehaily
The essential oil of Leucas inflata Balf.f. (Lamiaceae), collected in Yemen, was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. Forty-three components were recognized, representing 89.2% of the total oil. The L. inflata volatile oil was found to contain a high percentage of aliphatic acids (51.1%). Hexadecanoic acid (32.8%) and n-dodecanoic acid (7.8%) were identified as the major compounds. Oxygenated monoterpenes were distinguished as the second significant group of constituents (16...
February 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28251439/plant-volatiles-increase-sex-pheromone-attraction-of-holotrichia-parallela-coleoptera-scarabaeoidea
#3
Qian Ju, Xiao-Qiang Guo, Xiao Li, Xiao-Jing Jiang, Xiang-Guo Jiang, Wan-Li Ni, Ming-Jing Qu
Holotrichia parallela (Coleoptera: Scarabaeoidea) is a notorious pest of many crops. To improve the effectiveness of its female-produced sex pheromone (L-isoleucine methyl ester:(R)-(-)-linalool = 6:1), 14 plant volatiles, including dodecanoic acid, dodecanal, farnesol, α-farnesene, (Z)-3-hexen-1-ol, (E)-2-hexen-1-ol, (Z)-3-hexenyl acetate, (E)-2-hexenyl acetate, (R)-(+)-limonene, α-phellandrene, α-pinene, ocimene, methyl benzoate, and benzaldehyde, were individually evaluated using electroantennography and olfactometer assays...
March 2, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28211329/first-report-of-perfluoroalkyl-substances-in-south-african-odonata
#4
Velesia Lesch, Hindrik Bouwman, Ayako Kinoshita, Yasuyuki Shibata
Perfluorinated substances are global and ubiquitous pollutants. However, very little is known about these substances in invertebrates, and even less in terrestrial invertebrates in particular. We analysed adult male dragonflies from six sites in South Africa for perfluoroalkyl substances (PFASs), including perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluro-n-undecanoic acid (PFUnA), perfluoro-n-dodecanoic acid (PFDoA), perfluorohexanoic acid (PFHxA), and perfluorohexane sulfonic acid (PFHxS)...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28130121/synthesis-and-structure-activity-studies-on-novel-analogs-of-human-growth-hormone-releasing-hormone-ghrh-with-enhanced-inhibitory-activities-on-tumor-growth
#5
Marta Zarandi, Renzhi Cai, Magdolna Kovacs, Petra Popovics, Luca Szalontay, Tengjiao Cui, Wei Sha, Miklos Jaszberenyi, Jozsef Varga, XianYang Zhang, Norman L Block, Ferenc G Rick, Gabor Halmos, Andrew V Schally
The syntheses and biological evaluations of new GHRH analogs of Miami (MIA) series with greatly increased anticancer activity are described. In the design and synthesis of these analogs, the following previous substitutions were conserved: D-Arg(2), Har(9), Abu(15), and Nle(27). Most new analogs had Ala at position 8. Since replacements of both Lys(12) and Lys(21) with Orn increased resistance against enzymatic degradation, these modifications were kept. The substitutions of Arg at both positions 11 and 20 by His were also conserved...
March 2017: Peptides
https://www.readbyqxmd.com/read/28122817/structural-and-biological-characteristics-of-different-forms-of-v-filiformis-lipid-a-use-of-ms-to-highlight-structural-discrepancies
#6
Aude Breton, Alexey Novikov, Richard Martin, Pierre Tissieres, Martine Caroff
Vitreoscilla filiformis is a Gram-negative bacterium isolated from spa waters and described for its beneficial effects on the skin. We characterized the detailed structure of its lipopolysaccharide (LPS) lipid A moiety, an active component of the bacterium that contributes to the observed skin activation properties. Two different batches differing in postculture cell recovery were tested. Chemical analyses and mass spectra, obtained before and after mild-alkali treatments, revealed that these lipids A share the common bisphosphorylated β-(1→6)-linked d-glucosamine disaccharide with hydroxydecanoic acid in an amide linkage...
March 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/27966642/epoxygenated-fatty-acids-inhibit-retinal-vascular-inflammation
#7
Megan E Capozzi, Sandra S Hammer, Gary W McCollum, John S Penn
The objective of the present study was to assess the effect of elevating epoxygenated fatty acids on retinal vascular inflammation. To stimulate inflammation we utilized TNFα, a potent pro-inflammatory mediator that is elevated in the serum and vitreous of diabetic patients. In TNFα-stimulated primary human retinal microvascular endothelial cells, total levels of epoxyeicosatrienoic acids (EETs), but not epoxydocosapentaenoic acids (EDPs), were significantly decreased. Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expression and protein levels; conversely the diol product of 19,20-EDP hydrolysis, 19,20-DHDP, induced VCAM1 and ICAM1 expression...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904937/separation-of-cyclic-lipopeptide-puwainaphycins-from-cyanobacteria-by-countercurrent-chromatography-combined-with-polymeric-resins-and-hplc
#8
José Cheel, Petra Urajová, Jan Hájek, Pavel Hrouzek, Marek Kuzma, Elodie Bouju, Karine Faure, Jiří Kopecký
Puwainaphycins are a recently described group of β-amino fatty acid cyclic lipopeptides of cyanobacterial origin that possess interesting biological activities. Therefore, the development of an efficient method for their isolation from natural sources is necessary. Following the consecutive adsorption of the crude extract on Amberlite XAD-16 and XAD-7 resins, countercurrent chromatography (CCC) was applied to separate seven puwainaphycin variants from a soil cyanobacterium (Cylindrospermum alatosporum CCALA 988)...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27883174/maximization-of-cell-viability-rather-than-biocatalyst-activity-improves-whole-cell-%C3%AF-oxyfunctionalization-performance
#9
Marvin Kadisch, Mattijs K Julsing, Manfred Schrewe, Nico Jehmlich, Benjamin Scheer, Martin von Bergen, Andreas Schmid, Bruno Bühler
It is a common misconception in whole-cell biocatalysis to refer to an enzyme as the biocatalyst, thereby neglecting the structural and metabolic framework provided by the cell. Here, the low whole-cell biocatalyst stability, that is, the stability of specific biocatalyst activity, in a process for the terminal oxyfunctionalization of renewable fatty acid methyl esters was investigated. This reaction, which is difficult to achieve by chemical means, is catalyzed by Escherichia coli featuring the monooxygenase system AlkBGT and the uptake facilitator AlkL from Pseudomonas putida GPo1...
November 7, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27862650/synthesis-and-biological-activity-of-lipophilic-analogs-of-the-cationic-antimicrobial-active-peptide-anoplin
#10
Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis, Eugenia Panou-Pomonis
Anoplin is a short natural cationic antimicrobial peptide which is derived from the venom sac of the solitary wasp, Anoplius samariensis. Due to its short sequence G(1) LLKR(5) IKT(8) LL-NH2 , it is ideal for research tests. In this study, novel analogs of anoplin were prepared and examined for their antimicrobial, hemolytic activity, and proteolytic stability. Specific substitutions were introduced in amino acids Gly(1) , Arg(5) , and Thr(8) and lipophilic groups with different lengths in the N-terminus in order to investigate how these modifications affect their antimicrobial activity...
November 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/27792938/investigation-of-a-novel-fluorinated-surfactant-based-system-for-the-design-of-spherical-wormhole-like-mesoporous-silica
#11
Philippe Riachy, Gérald Lopez, Mélanie Emo, Marie-José Stébé, Jean-Luc Blin, Bruno Ameduri
In contrast to hydrogenated based systems that led to many studies, fluorinated surfactants have been little reported. Thanks to their high chemical and thermal stability, these compounds are considered as suitable candidates for the synthesis of porous materials with an enhanced hydrothermal stability. This study reports the synthesis of a new fluorinated surfactant, 2-trifluoromethyl-7,7,8,8,9,9,10,10,11,11,12,12,12-tridecafluoro-4-thia-1-dodecanoic acid (FSC) obtained from the thiol-ene radical addition of 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanethiol onto 2-trifluoromethyl acrylic acid in 85% yield...
February 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27780957/purification-and-properties-of-extracellular-lipases-with-transesterification-activity-and-1-3-regioselectivity-from-rhizomucor-miehei-and-rhizopus-oryzae
#12
Miklós Takó, Alexandra KotogÁn, TamÁs Papp, Shine Kadaikunnan, Naiyf S Alharbi, Csaba VÁgvölgyi
Rhizomucor miehei NRRL 5282 and Rhizopus oryzae NRRL 1526 can produce lipases with high synthetic activities in wheat bran-based solid-state culture. In this study, the purification and biochemical characterization of the lipolytic activities of these lipases are presented. SDS-PAGE indicated a molecular mass of about 55 and 35 kDa for the purified R. miehei and Rh. oryzae enzymes, respectively. p-Nitrophenyl palmitate (pNPP) hydrolysis was maximal at 40°C and pH 7.0 for the R. miehei lipase, and at 30°C and pH 5...
February 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27754504/dietary-fibers-influence-the-intestinal-scfas-and-plasma-metabolites-profiling-in-growing-pigs
#13
W Wu, J Xie, H Zhang
Dietary fibers (DFs), widely used as food additives to replace fat, can benefit metabolic disorders. Soluble and highly fermentable inulin (INU) and insoluble and less fermentable microcrystalline cellulose (MCC) have hypolipidemic or cholesterol-lowering effects, respectively. The current study was aimed at identifying plasma metabolite signatures and metabolic pathways associated with inclusion of DFs with different physiochemical properties, which will lead to a better understanding of functional pathways for DFs to improve metabolic health...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27738839/functional-genomics-analysis-of-free-fatty-acid-production-under-continuous-phosphate-limiting-conditions
#14
J Tyler Youngquist, Travis C Korosh, Brian F Pfleger
Free fatty acids (FFA) are an attractive platform chemical that serves as a functional intermediate in metabolic pathways for producing oleochemicals. Many groups have established strains of Escherichia coli capable of producing various chain-length mixtures of FFA by heterologous expression of acyl-ACP thioesterases. For example, high levels of dodecanoic acid are produced by an E. coli strain expressing the Umbellularia californica FatB2 thioesterase, BTE. Prior studies achieved high dodecanoic acid yields and productivities under phosphate-limiting media conditions...
October 13, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27732913/targeting-arachidonic-acid-pathway-to-prevent-programmed-hypertension-in-maternal-fructose-fed-male-adult-rat-offspring
#15
You-Lin Tain, Wei-Chia Lee, Kay L H Wu, Steve Leu, Julie Y H Chan
Hypertension can be programmed in response to nutritional insults in early life. Maternal high-fructose (HF) intake induced programmed hypertension in adult male offspring, which is associated with renal programming and arachidonic acid metabolism pathway. We examined whether early treatment with a soluble epoxide hydrolase (SEH) inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) or 15-Deoxy-Δ(12,14)-prostagandin J2 (15dPGJ2) can prevent HF-induced programmed hypertension. Pregnant Sprague Dawley rats received regular chow or chow supplemented with fructose (60% diet by weight) during the whole period of pregnancy and lactation...
September 7, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27573441/from-alkanes-to-carboxylic-acids-terminal-oxygenation-by-a-fungal-peroxygenase
#16
Andrés Olmedo, Carmen Aranda, José C Del Río, Jan Kiebist, Katrin Scheibner, Angel T Martínez, Ana Gutiérrez
A new heme-thiolate peroxidase catalyzes the hydroxylation of n-alkanes at the terminal position-a challenging reaction in organic chemistry-with H2 O2 as the only cosubstrate. Besides the primary product, 1-dodecanol, the conversion of dodecane yielded dodecanoic, 12-hydroxydodecanoic, and 1,12-dodecanedioic acids, as identified by GC-MS. Dodecanal could be detected only in trace amounts, and 1,12-dodecanediol was not observed, thus suggesting that dodecanoic acid is the branch point between mono- and diterminal hydroxylation...
September 26, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27556495/pharmacognostic-and-antioxidant-properties-of-dracaena-sanderiana-leaves
#17
Mei Gee Ong, Siti Nur Aishah Mat Yusuf, Vuanghao Lim
Endogenous and exogenous antioxidants are used to neutralise free radicals and protect the body from free radicals by maintaining the redox balance. The antioxidant properties of Dracaena sanderiana leaves were evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the total phenolic and flavonoid contents were measured. The classes of secondary metabolites were evaluated through pharmacognostic studies, and active compounds were identified by gas chromatography mass-spectrometry (GC-MS). All ethanol-water extracts and D...
August 20, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27529077/chemical-composition-and-antimicrobial-potential-of-palm-leaf-extracts-from-baba%C3%A3-u-attalea-speciosa-buriti-mauritia-flexuosa-and-maca%C3%A3%C2%BAba-acrocomia-aculeata
#18
Adriana Idalina Torcato de Oliveira, Talal Suleiman Mahmoud, Guilherme Nobre L do Nascimento, Juliana Fonseca Moreira da Silva, Raphael Sanzio Pimenta, Paula Benevides de Morais
Babaçu (A. speciosa), Buriti (M. flexuosa), and Macaúba (A. aculeata) are palm trees typical of the ecotone area between Cerrado and the Amazon rainforest. The purpose of this study was to evaluate the antimicrobial potential of the extracts prepared from the leaves of those palms as well as determine their chemical compositions. The ethanol extracts were prepared in a Soxhlet apparatus and tested by disk diffusion and agar dilution technique against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Candida parapsilosis...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27405438/biotransformation-of-chemical-constituents-of-durian-wine-with-simultaneous-alcoholic-fermentation-by-torulaspora-delbrueckii-and-malolactic-fermentation-by-oenococcus-oeni
#19
Yuyun Lu, Jian-Yong Chua, Dejian Huang, Pin-Rou Lee, Shao-Quan Liu
This work represents the first study on the biotransformation of chemical constituents of durian wine via simultaneous alcoholic fermentation (AF) and malolactic fermentation (MLF) with non-Saccharomyces yeast and lactic acid bacteria (LAB), namely, Torulaspora delbrueckii Biodiva and Oenococcus oeni PN4. The presence of PN4 improved the utilization of sugars but did not affect ethanol production. MLF resulted in the significant degradation of malic acid with corresponding increases in pH and lactic acid. The final concentrations of acetic acid (1...
October 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27353589/molecular-docking-and-simulation-studies-of-gustatory-receptor-of-aedes-aegypti-a-potent-drug-target-to-distract-host-seeking-behaviour-in-mosquitoes
#20
Krishna Kant Gupta, Guneswar Sethi, Manikandan Jayaraman
BACKGROUND & OBJECTIVES: It is well reported that exhaled CO 2 and skin odour from human being assist female mosquitoes to locate human host. Basically, the receptors for this activity are expressed in cpA neurons. In both Aedes aegypti and Anopheles gambiae, this CO 2-sensitive olfactory neuron detects myriad number of chemicals present in human skin. Therefore, manipulation of gustatory receptors housing these neurons may serve as important targets for behavioural intervention. The study was aimed towards virtual screening of small molecules in the analyzed conserved active site residues of gustatory receptor and molecular dynamics simulation study of optimum protein-ligand complex to identify a suitable lead molecule for distracting host-seeking behaviour of mosquitoes...
April 2016: Journal of Vector Borne Diseases
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