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iodine uptake

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https://www.readbyqxmd.com/read/29020767/confinement-of-iodine-molecules-into-triple-helical-chains-within-robust-metal-organic-frameworks
#1
Xinran Zhang, Ivan da Silva, Harry G W Godfrey, Samantha K Callear, Sergey A Sapchenko, Yongqiang Cheng, Inigo J Vitorica-Yrezabal, Mark D Frogley, Gianfelice Cinque, Chiu C Tang, Carlotta Giacobbe, Catherine Dejoie, Svemir Rudic, Anibal J Ramirez-Cuesta, Melissa A Denecke, Sihai Yang, Martin Schröder
During the nuclear waste disposal process, radioactive iodine in fission product can be released. The widespread implementation of sustainable nuclear energy thus requires the development of efficient iodine stores that have simultaneously high capacity, stability and more importantly, storage density (and hence minimised system volume). Here, we report high I2 adsorption in a series of robust porous metal-organic materials, MFM-300(M) (M = Al, Sc, Fe, In). MFM-300(Sc) exhibits fully reversible I2 uptake of 1...
October 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28991700/cardiac-sympathetic-denervation-and-dementia-in-de-novo-parkinson-s-disease-a-7-year-follow-up-study
#2
Mun Hee Choi, Jung Han Yoon, Suk Woo Yong
BACKGROUND: Postganglionic cardiac sympathetic denervation is evident in patients with early-stage Parkinson's disease (PD). Cardiac iodine-123-meta-iodobenzylguanidine (MIBG) uptake is correlated with the non-motor symptoms of PD, suggesting that low cardiac MIBG uptake may reflect wider alpha-synuclein pathology. In addition, low cardiac MIBG could be related to orthostatic hypotension in PD, which may affect cognition. However, the prognostic validity of baseline MIBG scintigraphy in terms of the risk of subsequent dementia remains unclear...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28972806/construction-of-nanostructured-dna-harbouring-phosphorodiamidate-morpholino-oligonucleotide-for-controlled-tissue-distribution-in-mice
#3
Yosuke Takahashi, Yuki Araie, Daiki Nomura, Yuki Takahashi, Kohei Sano, Hideo Saji, Yoshinobu Takakura, Makiya Nishikawa
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a class of antisense oligonucleotides used in the treatment of neuromuscular diseases. Their major drawbacks are high blood clearance and poor cellular delivery. Previously, we demonstrated that tripod-like nanostructured DNA, or tripodna, was efficiently taken up by macrophages and dendritic cells. In this study, we used iodine-125((125)I)-labelled PMOs, designed a tripodna harbouring an (125)I-PMO ((125)I-PMO/tripodna), and evaluated whether this tripodna could control the pharmacokinetic properties of PMO...
October 3, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28958220/collective-ion-pair-single-drop-microextraction-attenuated-total-reflectance-fourier-transform-infrared-spectroscopic-determination-of-perchlorate-in-bioenvironmental-samples
#4
Swati Chandrawanshi, Santosh K Verma, Manas K Deb
Perchlorate (ClO₄(−)) is an environmental pollutant thataffects human health. Perchlorate acts as a competitive inhibitor of iodine uptake in the thyroid gland (sodium–iodide symporter inhibitor); thus, its determination is important for public health concerns. Water and milk constitute a significant portion of the human diet. Because regular intake leads to an increase in perchlorate concentration in the human body, the estimation of perchlorate is of great concern. In this work, ion-pair single-drop microextraction (SDME) combined with attenuated total reflectance (ATR)-FTIR spectroscopy has been developed for the determination of perchlorate in bioenvironmental (soil, water, dairy milk, breast milk, and urine) samples...
September 28, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28949122/role-of-positron-emission-tomography-in-thyroid-and-neuroendocrine-tumours
#5
Giorgio Treglia, Alexander S Kroiss, Arnoldo Piccardo, Filippo Lococo, Prasanna Santhanam, Alessio Imperiale
BACKGROUND: Positron emission tomography (PET) is an established imaging method in oncology. PET/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MRI) are hybrid techniques which combine morphological information obtained by CT and MRI with functional data provided by PET. Several radiotracers evaluating different metabolic pathways or receptor status can be used as PET radiotracers to assess endocrine tumours such as thyroid tumours or neuroendocrine neoplasms (NENs)...
September 25, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28944001/recurrent-graves-hyperthyroidism-after-prolonged-radioiodine-induced-hypothyroidism
#6
REVIEW
Fariha Salman, Hooman Oktaei, Solomon Solomon, Ebenezer Nyenwe
BACKGROUND: Radioactive iodine (RAI) is the most cost effective therapy for Graves' disease (GD). Patients with GD who have become hypothyroid after therapeutic RAI, rarely develop recurrence of disease. Herein we describe a case of recurrence of thyrotoxicosis after 2 years of hypothyroidism. METHODS: We present the clinical features, laboratory findings, imaging and management of an unusual case of recurrent hyperthyroidism. RESULTS: A 48-year-old male presented to the emergency room with a 2-day history of palpitation, chest discomfort and 30 pounds of weight loss...
July 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28933539/a-3d-coordination-network-built-from-cu-ii-4cl3-h2o-2-linear-clusters-and-tetrapyridyl-tetrahedral-silane-ligands-reversible-iodine-uptake-and-friedel-crafts-alkylation-reactions
#7
Mahesh S Deshmukh, Atul Chaudhary, Pavel N Zolotarev, Ramamoorthy Boomishankar
A novel three-dimensional coordination network 1 in a new 4,5,6-connected topology (4,5,6T115) built from linear Cu(II)4Cl3(H2O)2 clusters and tetrahedral tetrakis(3-pyridyl)vinylsilane ligands is reported. Utilizing a similar tetrahedral ligand, tetrakis(3-pyridyl)ethylsilane, a different framework 2 having Cu(II)2Cl(H2O)2 clusters is obtained in tcs topology. The activated sample of 1 shows an excellent and reversible uptake of I2 in solid as well as in solution phases owing to the presence of uncoordinated chloride ions and electron rich vinylic groups in it...
October 2, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28926758/some-aspects-of-the-iodine-metabolism-of-the-giant-kelp-macrocystis-pyrifera-phaeophyceae
#8
Teresa M Tymon, Eric P Miller, Jennifer L Gonzales, Andrea Raab, Frithjof C Küpper, Carl J Carrano
Despite its paramount role in the functioning of coastal ecosystems, relatively little is known about halogen metabolism in giant kelp (Macrocystis pyrifera). This is an important shortcoming given the potential implications for marine and atmospheric chemical processes in the wide distribution range of Macrocystis. The work presented here constitutes the first in depth investigation of the uptake, efflux, and of the physiological function of iodide in this important kelp species. Iodide uptake and efflux rates were measured in adult sporophytes of Macrocystis under normal and stressed (exogenous hydrogen peroxide and an elicitor-triggered oxidative burst) conditions...
September 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#9
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28912982/severe-thyrotoxicosis-secondary-to-povidone-iodine-from-peritoneal-dialysis
#10
Kirstie Lithgow, Christopher Symonds
A 73-year-old male on home peritoneal dialysis (PD) with recent diagnosis of atrial fibrillation presented with fatigue and dyspnea. Hyperthyroidism was diagnosed with TSH < 0.01 mIU/L and FT4 > 100 pmol/L. He had no personal or family history of thyroid disease. There had been no exposures to CT contrast, amiodarone, or iodine. Technetium thyroid scan showed diffusely decreased uptake. He was discharged with a presumptive diagnosis of thyroiditis. Three weeks later, he had deteriorated clinically...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28910079/silver-loaded-aluminosilicate-aerogels-as-iodine-sorbents
#11
Brian J Riley, Jared O Kroll, Jacob A Peterson, Josef Matyáš, Matthew J Olszta, Xiaohong Li, John D Vienna
In this paper, aluminosilicate aerogels were used as scaffolds for silver nanoparticles to capture I2(g). The starting materials for these scaffolds included Na-Al-Si-O and Al-Si-O aerogels, both synthesized from metal alkoxides. The Ag(0) particles were added by soaking the aerogels in aqueous AgNO3 solutions followed by drying and Ag(+) reduction under H2/Ar to form Ag(0) crystallites within the aerogel matrix. In some cases, aerogels were thiolated with 3-(mercaptopropyl)trimethoxysilane as an alternative method for binding Ag(+)...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28883260/a-case-of-metastatic-follicular-thyroid-carcinoma-complicated-with-graves-disease-after-total-thyroidectomy
#12
Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Yasushi Nakagawa, Akira Tangoku
Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) therapy, during which the TSH receptor antibody (TRAb) was found to be negative...
September 5, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28866841/in-vivo-uptake-of-iodine-from-a-fucus-serratus-linnaeus-seaweed-bath-does-volatile-iodine-contribute
#13
Tarha Westby, Aodhmar Cadogan, Geraldine Duignan
Seaweed baths containing Fucus serratus Linnaeus are a rich source of iodine which has the potential to increase the urinary iodide concentration (UIC) of the bather. In this study, the range of total iodine concentration in seawater (22-105 µg L(-1)) and seaweed baths (808-13,734 µg L(-1)) was measured over 1 year. The seasonal trend shows minimum levels in summer (May-July) and maximum in winter (November-January). The bathwater pH was found to be acidic, average pH 5.9 ± 0.3. An in vivo study with 30 volunteers was undertaken to measure the UIC of 15 bathers immersed in the bath and 15 non-bathers sitting adjacent to the bath...
September 2, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28857212/normal-123-i-mibg-uptake-areas-may-be-associated-with-hyperinnervation-and-arrhythmia-risk-in-phenol-model-rabbit-hearts
#14
Mari Amino, Koichiro Yoshioka, Sachie Tanaka, Noboru Kawabe, Hiroyuki Kurosawa, Keisuke Uchida, Shinobu Oshikiri, Tadashi Hashida, Shigetaka Kanda, Sadaki Inokuchi, Yuji Ikari
BACKGROUND: Iodine-123 metaiodobenzylguanidine ((123) I-MIBG) is useful for detecting sympathetic innervation in the heart, and has been closely associated with fatal arrhythmias. However, such imaging is typically calibrated to the area of highest uptake and thus is unable to identify areas of hyperinnervation. We hypothesized that normal (123) I-MIBG uptake regions in the denervated heart would demonstrate nerve sprouting and correlate with the potential for arrhythmogenesis. METHODS: Twenty New Zealand white rabbits treated with phenol or sham were prepared under anesthesia...
August 31, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28853868/evaluation-of-iodine-bioavailability-in-seaweed-using-in-vitro-methods
#15
M Raquel Domínguez-González, Gabriela M Chiocchetti, Paloma Herbello-Hermelo, Dinoraz Vélez, Vicenta Devesa, Pilar Bermejo-Barrera
Due to the high levels of iodine present in seaweed, the ingestion of a large amount of this type of food can produce excessive intake of iodine. However, the food after ingestion undergoes different chemistry and physical processes that can modify the amount of iodine that reaches the systemic circulation (bioavailability). Studies on the bioavailability of iodine from food are scarce and indicate that the bioavailable amount is generally lower than ingested. Iodine in vitro bioavailability estimation from different commercialized seaweed has been studied using different in vitro approaches (solubility, dialyzability, and transport and uptake by intestinal cells)...
September 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28843268/effects-of-a-phosphoinositide-3-kinase-inhibitor-on-anaplastic-thyroid-cancer-stem-cells
#16
Farzaneh Bozorg-Ghalati, Mehdi Hedayati, Mehdi Dianatpour, Fereidoun Azizi, Nariman Mosaffa, Davood Mehrabani
Background: Thyroidectomy, radioactive iodine therapy, chemotherapy, or their combination are treatments of choice for thyroid cancers. However, cancer stem cells (CSCs) may become resistant to therapy, and mutations in somatic genes affect radioiodine uptake. This study determined the effect of a phosphoinositide-3-kinase (PI3K) inhibitor on anaplastic thyroid CSCs. Materials and Methods: The magnetic-activated cell sorting assay was used for segregating CD133-positive CSCs from three anaplastic thyroid carcinoma (ATC) cell lines (C643, SW1736, and 8305C)...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28840137/uptake-index-of-123-i-metaiodobenzylguanidine-myocardial-scintigraphy-for-diagnosing-lewy-body-disease
#17
Yoshito Kamiya, Satoru Ota, Shintaro Okumiya, Kosuke Yamashita, Akihiro Takaki, Shigeki Ito
OBJECTIVES: Iodine-123 metaiodobenzylguanidine ((123)I-MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The heart-to-mediastinum ratio (H/M) in PD and DLB is significantly lower than that in Parkinson's plus syndromes and Alzheimer's disease. Although this ratio is useful for distinguishing LBD from non-LBD, it fluctuates depending on the system performance of the gamma cameras...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28837607/a-validated-lc-ms-ms-method-for-cellular-thyroid-hormone-metabolism-uptake-and-turnover-of-mono-iodinated-thyroid-hormone-metabolites-by-pccl3-thyrocytes
#18
Keith H Richards, Nancy Schanze, Ray Monk, Eddy Rijntjes, Daniel Rathmann, Josef Köhrle
Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH metabolites (THM) with distinct biological properties. This needs to be considered when studying effects of TH and THM. The accurate and precise quantitative analysis of TH and THM in cell culture supernatants and cell lysates are key procedures required for studying the in vitro metabolism of TH...
2017: PloS One
https://www.readbyqxmd.com/read/28835993/metastatic-and-non-metastatic-lymph-nodes-quantification-and-different-distribution-of-iodine-uptake-assessed-by-dual-energy-ct
#19
Stefania Rizzo, Davide Radice, Marco Femia, Paolo De Marco, Daniela Origgi, Lorenzo Preda, Massimo Barberis, Raffaella Vigorito, Giovanni Mauri, Alberto Mauro, Massimo Bellomi
OBJECTIVES: To evaluate quantification of iodine uptake in metastatic and non-metastatic lymph nodes (LNs) by dual-energy CT (DECT) and to assess if the distribution of iodine within LNs at DECT correlates with the pathological structure. METHODS: Ninety LNs from 37 patients (23 with lung and 14 with gynaecological malignancies) were retrospectively selected. Information of LNs sent for statistical analysis included Hounsfield units (HU) at different energy levels; decomposition material densities fat-iodine, iodine-fat, iodine-water, water-iodine...
August 23, 2017: European Radiology
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#20
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
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