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https://www.readbyqxmd.com/read/28213878/cotransfecting-norepinephrine-transporter-and-vesicular-monoamine-transporter-2-genes-for-increased-retention-of-metaiodobenzylguanidine-labeled-with-iodine-131-in-malignant-hepatocarcinoma-cells
#1
Yanlin Zhao, Xiao Zhong, Xiaohong Ou, Huawei Cai, Xiaoai Wu, Rui Huang
Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine ((131)I-MIBG) in non-neuroendocrine tumors. However, the use of (131)I-MIBG is limited by its short retention time in target cells. To prolong the retention of (131)I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines...
February 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28198752/monoenergetic-dual-energy-computed-tomographic-imaging-cardiothoracic-applications
#2
Lukas Lenga, Moritz H Albrecht, Ahmed E Othman, Simon S Martin, Doris Leithner, Tommaso D'Angelo, Christophe Arendt, Jan-Erik Scholtz, Carlo N De Cecco, U Joseph Schoepf, Thomas J Vogl, Julian L Wichmann
Monoenergetic imaging is an increasingly used reconstruction technique in postprocessing of dual-energy computed tomography (DECT). The main advantage of this technique is the ability to substantially increase image contrast of structures with uptake of iodinated contrast material. Although monoenergetic imaging was mainly used in oncological DECT applications, recent research has further demonstrated its role in vascular imaging. Using this dedicated postprocessing algorithm, image contrast of vascular structures in the thorax can be increased, a drastic reduction of contrast material is feasible, and even beam-hardening artifacts can be reduced...
February 14, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28169369/fast-and-quantitative-t1%C3%AF-weighted-dynamic-glucose-enhanced-mri
#3
Patrick Schuenke, Daniel Paech, Christina Koehler, Johannes Windschuh, Peter Bachert, Mark E Ladd, Heinz-Peter Schlemmer, Alexander Radbruch, Moritz Zaiss
Common medical imaging techniques usually employ contrast agents that are chemically labeled, e.g. with radioisotopes in the case of PET, iodine in the case of CT or paramagnetic metals in the case of MRI to visualize the heterogeneity of the tumor microenvironment. Recently, it was shown that natural unlabeled D-glucose can be used as a nontoxic biodegradable contrast agent in Chemical Exchange sensitive Spin-Lock (CESL) magnetic resonance imaging (MRI) to detect the glucose uptake and potentially the metabolism of tumors...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28165926/tertiary-evaluation-of-the-committed-effective-dose-of-emergency-workers-that-responded-to-the-fukushima-daiichi-npp-accident
#4
Shojiro Yasui
In January 2014, Tokyo Electric Power Company (TEPCO) learned that the committed effective dose (CED) for nine emergency workers at the Fukushima Daiichi Nuclear Power Plant accident had been assessed by a method other than the standard assessment methods, established by the Ministry of Health, Labour and Welfare (MHLW) in a secondary evaluation conducted in July 2013. The MHLW requested that the TEPCO and primary contractors review all CED data for 6,245 workers who engaged in emergency work in March and April 2011 except those previously reviewed in the 2013 secondary evaluation...
February 6, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28149923/investigation-of-x-ray-spectra-for-iodinated-contrast-enhanced-dedicated-breast-ct
#5
Stephen J Glick, Andrey Makeev
Screening for breast cancer with mammography has been very successful, resulting in part to a reduction of breast cancer mortality by approximately 39% since 1990. However, mammography still has limitations in performance, especially for women with dense breast tissue. Iodinated contrast-enhanced, dedicated breast CT (BCT) has been proposed to improve lesion analysis and the accuracy of diagnostic workup for patients suspected of having breast cancer. A mathematical analysis to explore the use of various x-ray filters for iodinated contrast-enhanced BCT is presented...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28127555/preparation-and-characterization-of-hyaluronic-acid-polycaprolactone-copolymer-micelles-for-the-drug-delivery-of-radioactive-iodine-131-labeled-lipiodol
#6
Shih-Cheng Chen, Ming-Hui Yang, Tze-Wen Chung, Ting-Syuan Jhuang, Jean-Dean Yang, Ko-Chin Chen, Wan-Jou Chen, Ying-Fong Huang, Shiang-Bin Jong, Wan-Chi Tsai, Po-Chiao Lin, Yu-Chang Tyan
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28103285/radioiodinated-exendin-4-is-superior-to-the-radiometal-labelled-glucagon-like-peptide-1-receptor-probes-overcoming-their-high-kidney-uptake
#7
Tilman Läppchen, Roswitha Tönnesmann, Jos Eersels, Philipp T Meyer, Helmut R Maecke, Svetlana N Rylova
GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order to solve those issues we evaluated GLP-1R agonist Ex-4 and antagonist Ex(9-39) radioiodinated at Tyr40 side by side with [Nle14,Lys40(Ahx-DOTA-68Ga)NH2]Ex-4 (68Ga-Ex-4) used in the clinic. The Kd, Bmax, internalization and binding kinetics of [Nle14,125I-Tyr40-NH2]Ex-4 and [Nle14,125I-Tyr40-NH2]Ex(9-39) were studied in vitro using Ins-1E cells...
2017: PloS One
https://www.readbyqxmd.com/read/28102954/dosimetric-impact-of-lipiodol-in-stereotactic-body-radiation-therapy-on-liver-after-trans-arterial-chemoembolization
#8
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Teiji Nishio, Tomoki Kimura, Tatsuhiko Suzuki, Kazunari Hioki, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
PURPOSE: Stereotactic body radiation therapy (SBRT) combining trans-arterial chemoembolization (TACE) with Lipiodol is expected to improve local control. This study is aimed to estimate the dose enhancement in Lipiodol's proximity and to evaluate the dose calculation accuracy of the Acuros XB (AXB) algorithm and anisotropic analytical algorithm (AAA) in the Eclipse treatment planning system (TPS) (ver. 11, Varian Medical Systems, Palo Alto, USA), compared with that of the Monte Carlo (MC) calculation (using BEAMnrc/DOSXYZnrc code) for a virtual phantom and a treatment plan for liver SBRT after TACE...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28099584/iodine-131-treatment-of-thyroid-cancer-cells-leads-to-suppression-of-cell-proliferation-followed-by-induction-of-cell-apoptosis-and-cell-cycle-arrest-by-regulation-of-b-cell-translocation-gene-2-mediated-jnk-nf-%C3%AE%C2%BAb-pathways
#9
L M Zhao, A X Pang
Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters...
January 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28099007/pyridinium-boranephosphonate-modified-dna-oligonucleotides
#10
Subhadeep Roy, Sibasish Paul, Mithun Roy, Rajen Kundu, Luca Monfregola, Marvin H Caruthers
The synthesis of previously unknown derivatives of boranephosphonate that contain amine substitutions at boron and the incorporation of these derivatives into the backbone of DNA oligonucleotides is described. These derivatives result from iodine-mediated replacement of one BH3 hydride of a boranephosphonate linkage by pyridine, various substituted pyridines, other aromatic amines, and certain unsaturated amines. Oligonucleotides containing these backbone modifications show enhanced uptake, relative to unmodified DNA, in mammalian cells...
January 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28079354/effect-of-excess-iodine-intake-on-thyroid-on-human-health
#11
Eftychia G Koukkou, Nikolaos D Roupas, Kostas B Markou
The recommended daily intake of iodide, is 150 μg for adolescents and adults, 250 μg for pregnancy and lactation. Thyroid gland is an effective collector of iodine. The active iodine uptake along the basolateral membrane of thyroid cell is followed by its transport to the apical edge of the cell and then to the follicle lumen. TSH acts through cAMP and stimulates NIS gene expression and protein synthesis. The major proportion of iodine in the thyroid gland is bound to Thyroglobulin. The non-organic intrathyroidal iodine is usually low, but significantly greater compared to plasma...
April 2017: Minerva Medica
https://www.readbyqxmd.com/read/28000859/131i-labeled-monoclonal-antibody-targeting-neuropilin-receptor-type-2-for-tumor-spect-imaging
#12
Lichun Chen, Liangliang Wang, Jianghua Yan, Chao Ma, Jing Lu, Guoqiang Chen, Shengyou Chen, Fu Su, Weixing Wang, Xinhui Su
As a co-receptor for vascular endothelial growth factor‑3 (VEGF‑3), neuropilin receptor type‑2 (NRP‑2) plays a central role in lymphangiogenesis and angiogenesis. Recently, mounting data of evidence show that NRP‑2 is overexpressed in several human cancers, and its overexpression is often associated with poor prognosis. Therefore, it is necessary for us to develop an affinity reagent for noninvasive imaging of NRP‑2 expression because it may be possible to provide early cancer diagnosis, more accurate prognosis, and better treatment planning...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28000717/a-quantitative-comparison-of-micro-ct-preparations-in-dipteran-flies
#13
Peter Swart, Martina Wicklein, Dan Sykes, Farah Ahmed, Holger G Krapp
X-ray-based 3D-imaging techniques have gained fundamental significance in research areas ranging from taxonomy to bioengineering. There is demand for the characterisation of species-specific morphological adaptations, micro-CT (μCT) being the method of choice in small-scale animals. This has driven the development of suitable staining techniques to improve absorption-based tissue contrast. A quantitative account on the limits of current staining protocols for preparing μCT specimen, however, is still missing...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000685/update-on-dietary-intake-of-perchlorate-and-iodine-from-u-s-food-and-drug-administration-s-total-diet-study-2008-2012
#14
Eileen Abt, Judith Spungen, Régis Pouillot, Margaret Gamalo-Siebers, Mark Wirtz
The U.S. Food and Drug Administration's (FDA) Total Diet Study (TDS) monitors the US food supply for pesticide residues, industrial chemicals, radionuclides, nutrients, and toxic elements. Perchlorate and iodine intakes based on concentrations in TDS samples collected between 2008 and 2012 were estimated in order to update an earlier TDS dietary assessment. Perchlorate is used as an oxidizing agent in rocket and missile fuel, is formed naturally in the atmosphere, and occurs naturally in some soils. Because of perchlorate's presence in soil, and in irrigation, processing, and source water, it is widely found in food...
December 21, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27998776/follicular-thyroglobulin-induces-cathepsin-h-expression-and-activity-in-thyrocytes
#15
Kenzaburo Oda, Yuqian Luo, Aya Yoshihara, Yuko Ishido, Kengo Sekihata, Kensei Usukura, Mariko Sue, Naoki Hiroi, Takahisa Hirose, Koichi Suzuki
Thyroglobulin (Tg) stored in thyroid follicles exerts a potent negative-feedback effect on each step of pre-hormone biosynthesis, including Tg gene transcription and iodine uptake and organification, by suppressing the expression of specific transcription factors that regulate these steps. Pre-hormones are stored in the follicular colloid before being reabsorbed. Following lysosomal proteolysis of its precursor, thyroid hormone (TH) is released from thyroid follicles. Although the suppressive effects of follicular Tg on each step of pre-hormone biosynthesis have been extensively characterized, whether follicular Tg accumulation also affects hormone reabsorption, proteolysis, and secretion is unclear...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27997357/effect-of-the-micronutrient-iodine-in-thyroid-carcinoma-angiogenesis
#16
Kayla Daniell, Carmelo Nucera
Iodide is a micronutrient essential for thyroid hormone production. The uptake and metabolism of iodide by thyrocytes is crucial to proper thyroid function. Iodide ions are drawn into the thyroid follicular cell via the sodium-iodide symporter (NIS) in the cell membrane and become integrated into tyrosyl residues to ultimately form thyroid hormones. We sought to learn how an abnormal concentration of iodide within thyrocyte can have significant effects on the thyroid, specifically the surrounding vascular network...
December 20, 2016: Aging
https://www.readbyqxmd.com/read/27994688/iodine-uptake-patterns-on-post-ablation-whole-body-scans-are-related-to-elevated-serum-thyroglobulin-levels-after-radioactive-iodine-therapy-in-patients-with-papillary-thyroid-carcinoma
#17
Geum-Cheol Jeong, Minchul Song, Hee Jeong Park, Jung-Joon Min, Hee-Seung Bom, Sang-Geon Cho, Ki Seong Park, Sae-Ryung Kang, Jahae Kim, Ho-Chun Song, Seong Young Kwon
PURPOSE: Serum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy. The authors studied the relationship between the elevation of serum Tg after RAI therapy and iodine uptake pattern on post-ablation whole body scans (RxWBSs) in patients with papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: The study subjects were patients with PTC that had undergone first RAI therapy with thyroid hormone withdrawal after total thyroidectomy...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988801/measuring-the-actual-i-131-thyroid-uptake-curve-with-a-collar-detector-system-a-feasibility-study
#18
Peter Brinks, Koen Van Gils, Ellen Kranenborg, Jules Lavalaye, Dennis B M Dickerscheid, Jan B A Habraken
Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy...
December 17, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27987437/theranostic-approach-for-metastatic-pigmented-melanoma-using-icf15002-a-multimodal-radiotracer-for-both-pet-imaging-and-targeted-radionuclide-therapy
#19
Latifa Rbah-Vidal, Aurélien Vidal, Emilie M F Billaud, Sophie Besse, Isabelle Ranchon-Cole, Florence Mishellany, Yann Perrot, Lydia Maigne, Nicole Moins, Jean-Luc Guerquin-Kern, Françoise Degoul, Jean-Michel Chezal, Philippe Auzeloux, Elisabeth Miot-Noirault
PURPOSE: This work reports, in melanoma models, the theranostic potential of ICF15002 as a single fluorinated and iodinated melanin-targeting compound. METHODS: Studies were conducted in the murine syngeneic B16BL6 model and in the A375 and SK-MEL-3 human xenografts. ICF15002 was radiolabeled with fluorine-18 for positron emission tomography (PET) imaging and biodistribution, with iodine-125 for metabolism study, and iodine-131 for targeted radionuclide therapy (TRT)...
December 14, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27930576/hyperthyroidism-secondary-to-hysterosalpingography-an-extremely-rare-complication-a-case-report
#20
Guotao Ma, Rui Mao, Haixin Zhai
RATIONALE: Hysterosalpingography (HSG), a standard procedure for the evaluation of women with infertility and repetitive pregnancy loss, is associated with complications such as uterine perforation, infection, allergic reactions, syncope, hemorrhage and shock, and pulmonary or retinal embolus. However, hyperthyroidism has not been reported as one of its complications. PATIENT CONCERNS AND DIAGNOSES: We report the case of a 33-year-old euthyroid woman who presented to our hospital with palpitation, hand tremor, fatigue, and excessive sweating after HSG...
December 2016: Medicine (Baltimore)
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