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https://www.readbyqxmd.com/read/28079354/effect-of-excess-iodine-intake-on-thyroid-on-human-health
#1
Eftychia G Koukkou, Nikolaos D Roupas, Kostas B Markou
INTRODUCTION: The recommended daily intake of iodide, is 150 μg for adolescents and adults, 175 μg for pregnancy and 200 μg for lactation. Thyroid gland is an effective collector of iodine. EVIDENCE ACQUISITION: The active iodine uptake along the basolateral membrane of thyroid cell is followed by its transport to the apical edge of the cell and then to the follicle lumen. TSH acts through cAMP and stimulates NIS gene expression and protein synthesis. The major proportion of iodine in the thyroid gland is bound to Thyroglobulin...
January 12, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28000859/131i-labeled-monoclonal-antibody-targeting-neuropilin-receptor-type-2-for-tumor-spect-imaging
#2
Lichun Chen, Liangliang Wang, Jianghua Yan, Chao Ma, Jing Lu, Guoqiang Chen, Shengyou Chen, Fu Su, Weixing Wang, Xinhui Su
As a co-receptor for vascular endothelial growth factor‑3 (VEGF‑3), neuropilin receptor type‑2 (NRP‑2) plays a central role in lymphangiogenesis and angiogenesis. Recently, mounting data of evidence show that NRP‑2 is overexpressed in several human cancers, and its overexpression is often associated with poor prognosis. Therefore, it is necessary for us to develop an affinity reagent for noninvasive imaging of NRP‑2 expression because it may be possible to provide early cancer diagnosis, more accurate prognosis, and better treatment planning...
December 16, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/28000717/a-quantitative-comparison-of-micro-ct-preparations-in-dipteran-flies
#3
Peter Swart, Martina Wicklein, Dan Sykes, Farah Ahmed, Holger G Krapp
X-ray-based 3D-imaging techniques have gained fundamental significance in research areas ranging from taxonomy to bioengineering. There is demand for the characterisation of species-specific morphological adaptations, micro-CT (μCT) being the method of choice in small-scale animals. This has driven the development of suitable staining techniques to improve absorption-based tissue contrast. A quantitative account on the limits of current staining protocols for preparing μCT specimen, however, is still missing...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000685/update-on-dietary-intake-of-perchlorate-and-iodine-from-u-s-food-and-drug-administration-s-total-diet-study-2008-2012
#4
Eileen Abt, Judith Spungen, Régis Pouillot, Margaret Gamalo-Siebers, Mark Wirtz
The U.S. Food and Drug Administration's (FDA) Total Diet Study (TDS) monitors the US food supply for pesticide residues, industrial chemicals, radionuclides, nutrients, and toxic elements. Perchlorate and iodine intakes based on concentrations in TDS samples collected between 2008 and 2012 were estimated in order to update an earlier TDS dietary assessment. Perchlorate is used as an oxidizing agent in rocket and missile fuel, is formed naturally in the atmosphere, and occurs naturally in some soils. Because of perchlorate's presence in soil, and in irrigation, processing, and source water, it is widely found in food...
December 21, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27998776/follicular-thyroglobulin-induces-cathepsin-h-expression-and-activity-in-thyrocytes
#5
Kenzaburo Oda, Yuqian Luo, Aya Yoshihara, Yuko Ishido, Kengo Sekihata, Kensei Usukura, Mariko Sue, Naoki Hiroi, Takahisa Hirose, Koichi Suzuki
Thyroglobulin (Tg) stored in thyroid follicles exerts a potent negative-feedback effect on each step of pre-hormone biosynthesis, including Tg gene transcription and iodine uptake and organification, by suppressing the expression of specific transcription factors that regulate these steps. Pre-hormones are stored in the follicular colloid before being reabsorbed. Following lysosomal proteolysis of its precursor, thyroid hormone (TH) is released from thyroid follicles. Although the suppressive effects of follicular Tg on each step of pre-hormone biosynthesis have been extensively characterized, whether follicular Tg accumulation also affects hormone reabsorption, proteolysis, and secretion is unclear...
December 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27997357/effect-of-the-micronutrient-iodine-in-thyroid-carcinoma-angiogenesis
#6
Kayla Daniell, Carmelo Nucera
Iodide is a micronutrient essential for thyroid hormone production. The uptake and metabolism of iodide by thyrocytes is crucial to proper thyroid function. Iodide ions are drawn into the thyroid follicular cell via the sodium-iodide symporter (NIS) in the cell membrane and become integrated into tyrosyl residues to ultimately form thyroid hormones. We sought to learn how an abnormal concentration of iodide within thyrocyte can have significant effects on the thyroid, specifically the surrounding vascular network...
December 20, 2016: Aging
https://www.readbyqxmd.com/read/27994688/iodine-uptake-patterns-on-post-ablation-whole-body-scans-are-related-to-elevated-serum-thyroglobulin-levels-after-radioactive-iodine-therapy-in-patients-with-papillary-thyroid-carcinoma
#7
Geum-Cheol Jeong, Minchul Song, Hee Jeong Park, Jung-Joon Min, Hee-Seung Bom, Sang-Geon Cho, Ki Seong Park, Sae-Ryung Kang, Jahae Kim, Ho-Chun Song, Seong Young Kwon
PURPOSE: Serum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy. The authors studied the relationship between the elevation of serum Tg after RAI therapy and iodine uptake pattern on post-ablation whole body scans (RxWBSs) in patients with papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: The study subjects were patients with PTC that had undergone first RAI therapy with thyroid hormone withdrawal after total thyroidectomy...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988801/measuring-the-actual-i-131-thyroid-uptake-curve-with-a-collar-detector-system-a-feasibility-study
#8
Peter Brinks, Koen Van Gils, Ellen Kranenborg, Jules Lavalaye, Dennis B M Dickerscheid, Jan B A Habraken
Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy...
December 17, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27987437/theranostic-approach-for-metastatic-pigmented-melanoma-using-icf15002-a-multimodal-radiotracer-for-both-pet-imaging-and-targeted-radionuclide-therapy
#9
Latifa Rbah-Vidal, Aurélien Vidal, Emilie M F Billaud, Sophie Besse, Isabelle Ranchon-Cole, Florence Mishellany, Yann Perrot, Lydia Maigne, Nicole Moins, Jean-Luc Guerquin-Kern, Françoise Degoul, Jean-Michel Chezal, Philippe Auzeloux, Elisabeth Miot-Noirault
PURPOSE: This work reports, in melanoma models, the theranostic potential of ICF15002 as a single fluorinated and iodinated melanin-targeting compound. METHODS: Studies were conducted in the murine syngeneic B16BL6 model and in the A375 and SK-MEL-3 human xenografts. ICF15002 was radiolabeled with fluorine-18 for positron emission tomography (PET) imaging and biodistribution, with iodine-125 for metabolism study, and iodine-131 for targeted radionuclide therapy (TRT)...
December 14, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27930576/hyperthyroidism-secondary-to-hysterosalpingography-an-extremely-rare-complication-a-case-report
#10
Guotao Ma, Rui Mao, Haixin Zhai
RATIONALE: Hysterosalpingography (HSG), a standard procedure for the evaluation of women with infertility and repetitive pregnancy loss, is associated with complications such as uterine perforation, infection, allergic reactions, syncope, hemorrhage and shock, and pulmonary or retinal embolus. However, hyperthyroidism has not been reported as one of its complications. PATIENT CONCERNS AND DIAGNOSES: We report the case of a 33-year-old euthyroid woman who presented to our hospital with palpitation, hand tremor, fatigue, and excessive sweating after HSG...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27904869/value-of-dedicated-head-and-neck-18-f-fdg-pet-ct-protocol-in-detecting-recurrent-and-metastatic-lesions-in-post-surgical-differentiated-thyroid-carcinoma-patients-with-high-serum-thyroglobulin-level-and-negative-131-i-whole-body-scan
#11
Mai Hong Son, Bui Quang Bieu, Le Ngoc Ha
OBJECTIVES: In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative (131)I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of (18)F-FDG PET/CT scan in DTC patients with high serum Tg level and negative (131)I WBS. METHODS: 69 post-surgical DTC patients with high serum Tg level and negative post ablation (131)I WBS were enrolled in this study...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27898646/iodine-123-metaiodobenzylguanidine-scintigraphy-for-the-assessment-of-cardiac-sympathetic-innervation-and-the-relationship-with-cardiac-autonomic-function-in-healthy-adults-using-standardized-methods
#12
Omar Asghar, Parthiban Arumugam, Ian Armstrong, Simon Ray, Matthias Schmitt, Rayaz A Malik
BACKGROUND: Global iodine-123 metaiodobenzylguanidine (I-MIBG) uptake is predictive of cardiovascular events and mortality in patients with heart failure. Normal variations in global and regional uptake, however, are not well defined and few studies have addressed the functional relevance of I-MIBG uptake and distribution in healthy individuals. MATERIALS AND METHODS: We performed I-MIBG scintigraphy and cardiac autonomic function testing using the standardized methodology in 15 healthy individuals (mean age 54...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27863957/ex-vivo-complexation-skin-permeation-interaction-and-cytodermal-toxicity-studies-of-p-tertbutylcalix-4-arene-nanoemulsion-for-radiation-decontamination
#13
Navneet Sharma, Himanshu Ojha, Dharam Pal Pathak, Rajeev Goel, Rakesh Kumar Sharma
AIMS: p-tertbutylcalix[4]arene loaded nanoemulsion has been designed, characterized and evaluated for skin decontamination of radionuclides of interest in nuclear and radiological emergencies. Further, nanoemulsion was evaluated for Ex-vivo complexation, skin permeation, interaction and cytodermal toxicity. MATERIALS AND METHODS: Ex-vivo skin complexation studies were conducted using High-resolution sector field inductively coupled plasma mass spectroscopy (HR-SF-ICPMS)...
January 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/27861299/impact-of-concomitant-medication-use-on-myocardial-123i-mibg-imaging-results-in-patients-with-heart-failure
#14
Arnold F Jacobson, Susan White, Mark I Travin, Carol Tseng
INTRODUCTION: Medications that interfere with sympathetic neuronal norepinephrine uptake and storage, such as neuropsychiatrics (NP) and sympathomimetic amines, are most likely to affect cardiac uptake of iodine-123 metaiodobenzylguanidine (I-mIBG). The present study examined these and other medications reported to affect I-mIBG uptake using measurements of cardiac I-mIBG uptake on the heart failure (HF) patients in the ADMIRE-HF extension (X) study. METHODS: Baseline concomitant medications taken by the 961 HF patients were categorized into five groups: calcium channel blockers, NP medications, β agonists and sympathomimetics, α antagonists, and other antihypertensives...
November 16, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27853073/feminizing-adrenocortical-carcinoma-with-distinct-histopathological-findings
#15
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27846003/imaging-of-prostate-specific-membrane-antigen-expression-in-metastatic-differentiated-thyroid-cancer-using-68ga-hbed-cc-psma-pet-ct
#16
Susanne Lütje, Benedikt Gomez, Joseph Cohnen, Lale Umutlu, Martin Gotthardt, Thorsten D Poeppel, Andreas Bockisch, Sandra Rosenbaum-Krumme
PURPOSE: The prostate-specific membrane antigen (PSMA) was shown to be overexpressed on the neovasculature of several malignancies. Here, the role of Ga-HBED-CC-PSMA PET/CT for the detection of PSMA expression in patients with metastasized differentiated thyroid cancer (DTC) was evaluated. METHODS: Six patients with iodine-negative and F-FDG-positive metastasized DTC (mean TG, 1616 ng/mL) received 71-93 MBq of the Ga-labeled PSMA ligand and underwent PET/CT at 62 ± 7 minutes p...
January 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27829313/taz-induction-directs-differentiation-of-thyroid-follicular-cells-from-human-embryonic-stem-cells
#17
Risheng Ma, Syed A Morshed, Rauf Latif, Terry F Davies
OBJECTIVE: The differentiation program for human thyroid follicular cells (TFCs) relies on the interplay between sequence-specific transcription factors and transcriptional co-regulators. Transcriptional co-activator with PDZ-binding motif (TAZ) is a co-activator that regulates several transcription factors, including PAX8 and NKX2-1, which play a central role in thyroid-specific gene transcription. TAZ and PAX8/NKX2-1 are co-expressed in the nuclei of thyroid cells, and TAZ interacts directly with both PAX8 and NKX2-1, leading to their enhanced transcriptional activity on the thyroglobulin (TG) promoter and additional genes...
January 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27824968/an-intrapericardial-ectopic-thyroid-mimicking-metastasis-in-a-patient-with-papillary-thyroid-cancer-localization-differential-diagnosis-by-18-f-fdg-pet-ct-and-ablation-by-131-i
#18
Seol Hoon Park, Minjung Seo, Tae Young Park, Seong Nam-Goong
We report a very rare case of incidental intrapericardial thyroid in a papillary thyroid cancer patient. Post ablation scan revealed iodine-131 ((131)I) uptake in the mid-chest. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed and showed a (18)F-FDG avid lesion between the right atrium and the ascending aorta, (which was) shown to be an ectopic thyroid and not metastasis. The lesion disappeared on a 6 month follow-up (123)I whole body scan while serum thyroglobulin was negative...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27813621/incidental-thyroid-99mtc-mdp-uptake-in-a-patient-affected-by-differentiated-thyroid-cancer
#19
Domenico Albano, Gian Carlo Magri, Giorgio Treglia, Francesco Bertagna
We report a case of incidental uptake of 99mTc-methylene diphosphonate in the thyroid in a 62-year-old female with a history of breast cancer treated with quadrantectomy, chemotherapy and radiotherapy, who underwent total-body-bone scintigraphy during follow up. Planar scintigraphy was followed by neck SPECT-CT that demonstrated an area of increased tracer uptake in the neck at the left lobe of the thyroid. Neck ultrasonography showed a nodule corresponding to SPECT-CT finding and the ultrasound-guided fine needle aspiration documented the presence of papillary carcinoma...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27801741/extrathyroidal-radioiodine-accumulation-in-a-fibroadenoma-of-the-breast
#20
Myoung Hyoun Kim, Hun Soo Kim, Soon-Ah Park
A 45-year-old woman with a differentiated thyroid carcinoma received adjuvant radioiodine therapy following total thyroidectomy and left modified radical neck dissection. A posttherapy planar radioiodine scan showed multifocal uptake in the thyroid bed and left chest. SPECT/CT revealed a fibroadenoma in the left breast. Six months later, an I scan showed no iodine avidity in the breast fibroadenoma, whereas ultrasonography showed no significant change in the size of the fibroadenoma. Altered radioiodine uptake of a breast fibroadenoma can be observed on follow-up scans after cytotoxic radioiodide treatment in patients with differentiated thyroid carcinoma...
October 31, 2016: Clinical Nuclear Medicine
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