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https://www.readbyqxmd.com/read/28423638/her-inhibitor-promotes-braf-mek-inhibitor-induced-redifferentiation-in-papillary-thyroid-cancer-harboring-brafv600e
#1
Lingxiao Cheng, Yuchen Jin, Min Liu, Maomei Ruan, Libo Chen
Redifferentiation therapy with BRAF/MEK inhibitors to facilitate treatment with radioiodine represents a good choice for radioiodine-refractory differentiated thyroid carcinoma, but recent initial clinical outcomes were modest. MAPK rebound caused by BRAF/MEK inhibitors-induced activation of HER2/HER3 is a resistance mechanism, and combination with HER inhibitor to prevent MAPK rebound may sensitize BRAFV600E-mutant thyroid cancer cells to redifferentiation therapy. To evaluate if inhibiting both BRAF/MEK and HER can produce stronger redifferetiation effect, we tested the effects of BRAF/MEK inhibitor dabrafenib/selumetinib alone or in combination with HER inhibitor lapatinib on the expression and function of iodine- and glucose-handling genes in BRAFV600E-positive BCPAP and K1 cells, using BHP 2-7 cells harboring RET/PTC1 rearrangement as control...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417080/applying-a-systems-approach-to-thyroid-physiology-looking-at-the-whole-with-a-mitochondrial-perspective-instead-of-judging-single-tsh-values-or-why-we-should-know-more-about-mitochondria-to-understand-metabolism
#2
REVIEW
Roy Moncayo, Helga Moncayo
Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. In this paper we want to challenge this model of limited application by proposing a construct based on a systems approach departing from two basic considerations. In first place since the majority of cases of thyroid disease develop and appear during life it has to be considered as an acquired condition...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28414279/short-term-effects-of-radioiodine-therapy-on-auditory-function
#3
Deniz Tuna Edizer, Suat Bilici, Muhammet Yıldız, Özgür Yiğit, Tevfik Fikret Çermik
OBJECTIVE: Radioiodine therapy (RIT) is frequently utilized as an adjunctive treatment option for differentiated thyroid carcinoma following surgical intervention. The side effects of RIT are considered to emerge as a result of radioiodine accumulation in non-thyroidal tissues capable of iodine uptake. We aimed to evaluate the effects of RIT on auditory function. MATERIALS AND METHODS: Patients who had undergone total thyroidectomy and diagnosed to have differentiated thyroid carcinoma were analyzed...
April 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28413794/comparative-evaluation-of-iodine-131-metaiodobenzylguanidine-and-18-fluorodeoxyglucose-positron-emission-tomography-in-assessing-neural-crest-tumors-will-they-play-a-complementary-role
#4
Soumyakanti Kundu, Purushottam Kand, Sandip Basu
BACKGROUND: 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) has established a role in the evaluation of several malignancies. However, its precise clinical role in the neural crest cell tumors continues to evolve. PURPOSE: The purpose of this study was to compare iodine-131 metaiodobenzylguanidine ((131)I-MIBG) and FDG-PET of head to head in patients with neural crest tumors both qualitatively and semiquantitatively and to determine their clinical utility in disease status evaluation and further management...
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28409122/a-post-publication-analysis-of-the-idealized-upper-reference-value-of-2-5%C3%A2-miu-l-for-tsh-time-to-support-the-thyroid-axis-with-magnesium-and-iron-especially-in-the-setting-of-reproduction-medicine
#5
Roy Moncayo, Helga Moncayo
Laboratory medicine approaches the evaluation of thyroid function mostly through the single determination of the blood level of thyroid stimulating hormone (TSH). Some authors have suggested an upper reference value for TSH of 2.5 mIU/L. This suggestion has not been confirmed by recent clinical studies. These studies have delivered a clinically valid reference range going from 0.3 to 3.5 mIU/L. These values are valid for both for the general population as well as in the setting of fertility and pregnancy...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28408701/low-grade-mucoepidermoid-tumor-of-parotid-gland-presenting-as-focal-asymmetry-in-the-follow-up-radioiodine-scan-in-a-patient-of-differentiated-papillary-carcinoma-of-thyroid
#6
Chinna Naik, Sandip Basu
Low grade mucoepidermoid tumor of the right parotid gland presenting as focal uptake in the follow-up whole body iodine scan in a patient of differentiated papillary carcinoma of thyroid 1 year after successful ablation is presented in this report. Following surgical excision, the histopathology was proven. The illustrated case represents false positive focal accumulation of (131)I in low grade mucoepidermoid carcinoma of the salivary gland that arose early in the follow-up course in differentiated thyroid carcinoma post-radioiodine (RAI)...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28408530/alternative-means-of-estimating-131-i-maximum-permissible-activity-to-treat-thyroid-cancer
#7
Kenneth J Nichols, William Robeson, Miyuki Yoshida-Hay, Pat B Zanzonico, Fritzgerald C Leveque, Kuldeep K Bhargava, Gene G Tronco, Christopher J Palestro
To protect bone marrow from over-irradiation, maximum permissible activity (MPA) of iodine-131 ((131)I) to treat thyroid cancer is that which limits absorbed dose to blood (as a surrogate of marrow) to < 200 cGy. The conventional approach (Method-1) requires repeated gamma-camera whole-body measurements along with blood samples. We sought to determine whether reliable MPA values can be obtained by simplified procedures. Methods: Data acquired over multiple time points were examined retrospectively for 65 thyroid cancer patients, referred to determine (131)I uptake and MPA for initial treatment following thyroidectomy (N = 39), including 17 patients with compromised renal function and 22 patients with known (N = 16) or suspected (N = 6) metastases...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28401794/chinese-data-of-efficacy-of-low-and-high-dose-of-iodine-131-for-the-ablation-of-thyroid-remnant
#8
Chao Ma, Fang Feng, Shaoyan Wang, Hongliang Fu, Shuqi Wu, Zhiyi Ye, Suyun Chen, Hui Wang
BACKGROUND: Chinese data of efficacy of low- and high-dose of radioiodine for thyroid remnant is still absent. The aim of the study is to investigate whether the low-dose of radioiodine is as effective as high-dose for remnant ablation in Chinese patients. METHODS: Patients presenting for radioiodine ablation in our department were included. Inclusion criteria were an age of 16 years or older; total or near total thyroidectomy; tumor-node-metastasis (TNM) stage of pT1-3, any N stage and M0...
April 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28381805/investigation-of-biodistribution-and-speciation-changes-of-orally-administered-dual-radiolabeled-complex-bis-5-chloro-7-131-i-iodo-8-quinolinolato-65-zn-zinc
#9
Masayuki Munekane, Masashi Ueda, Shinji Motomura, Shinichiro Kamino, Hiromitsu Haba, Yutaka Yoshikawa, Hiroyuki Yasui, Shuichi Enomoto
Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activities, for which moderate stability of Zn complexes is vital. The complexation of Zn plays a major role improving its bioavailability. However, investigation of the speciation changes of Zn complexes after oral administration is lacking. A dual radiolabeling approach was applied in order to investigate the speciation of bis(5-chloro-7-iodo-8-quinolinolato)zinc complex [Zn(Cq)2], which exhibits the antidiabetic activity in diabetic mice...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28365805/exposure-of-the-us-population-to-nitrate-thiocyanate-perchlorate-and-iodine-based-on-nhanes-2005-2014
#10
Lisa M Corey, Gavin P Bell, Richard C Pleus
Perchlorate, thiocyanate, nitrate, and iodide all have the same action of iodide uptake inhibition. Urinary samples were available for the US population through the National Health and Nutrition Examination Survey (NHANES) database for these compounds and were evaluated for the 2005 through 2014 time period. We were interested in whether exposures to the US population had changed since the mid-2000s. Given that these exposures were largely naturally derived and exposure was from food, we hypothesized that the levels of nitrate, thiocyanate, and perchlorate remained relatively stable over this time period...
April 1, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28348902/atypical-complications-of-graves-disease-a-case-report-and-literature-review
#11
Khaled Ahmed Baagar, Mashhood Ahmed Siddique, Shaimaa Ahmed Arroub, Ahmed Hamdi Ebrahim, Amin Ahmed Jayyousi
Graves' disease (GD) may display uncommon manifestations. We report a patient with rare complications of GD and present a comprehensive literature review. A 35-year-old woman presented with a two-week history of dyspnea, palpitations, and edema. She had a raised jugular venous pressure, goiter, and exophthalmos. Laboratory tests showed pancytopenia, a raised alkaline phosphatase level, hyperbilirubinemia (mainly direct bilirubin), and hyperthyroidism [TSH: <0.01 mIU/L (reference values: 0.45-4.5), fT4: 54...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28315910/effect-of-selenium-supplementation-for-protection-of-salivary-glands-from-iodine-131-radiation-damage-in-patients-with-differentiated-thyroid-cancer
#12
Haiyoung Son, Sang Mi Lee, Ra Gyoung Yoon, Hakmin Lee, Ilkyun Lee, Soon Kim, Woong Youn Chung, Jeong Won Lee
OBJECTIVE: In the current study, we examined whether selenium supplementation during iodine-131 ((131)I) treatment had a radio-protective effect on salivary glands. SUBJECTS AND METHODS: Sixteen patients with differentiated thyroid cancer were prospectively enrolled in the study. Patients after total thyroidectomy, before (131)I treatment, were divided into two groups; 8 patients in the selenium group and 8 patients in the control group. Patients in the selenium group received 300νg of selenium orally for 10 days, from 3 days before to 6 days after (131)I treatment...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315150/radioiodination-and-preclinical-evaluation-of-4-benzyl-1-3-125-i-iodobenzylsulfonyl-piperidine-as-a-breast-tumor-imaging-tracer-in-mouse
#13
Masoud Sadeghzadeh, Behrouz Alirezapour, Ghorban Ali Charkhlooie, Maryam Keshavarz Baghery, Amir Khorouti
OBJECTIVE: 4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[(125)I]-iodobenzylsulfonyl)piperidine, 4-B-[(125)I]IBSP, in human ductal breast carcinoma (T47D) cells and in breast adenocarcinoma-bearing BALB/c mice are described. METHODS: Radioiodination of this new σ ligand was performed by a palladium-catalyzed stannylation approach followed by oxidative iododestannylation reaction using Iodo-Gen...
May 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28306621/prognostic-value-of-preoperative-18f-fdg-pet-ct-in-papillary-thyroid-cancer-patients-with-a-high-metastatic-lymph-node-ratio-a-multicenter-retrospective-cohort-study
#14
Seong Young Kwon, Eun Kyoung Choi, Eun Jung Kong, Ari Chong, Jung-Min Ha, Kyung Ah Chun, Ihn Ho Cho, Hee-Seung Bom, Jung-Joon Min, Jahae Kim, Ho-Chun Song, Joo Hyun O, Sung Hoon Kim
OBJECTIVE: Metastatic lymph node ratio (MLNR) is a known significant predictor of disease-free survival in differentiated thyroid cancer. The authors investigated the ability of preoperative fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT to predict recurrence after surgery with radioactive iodine therapy considering MLNR. PATIENTS AND METHODS: A total of 274 patients who underwent preoperative PET/CT and surgery with radioactive iodine therapy were enrolled. The tumor-to-liver uptake ratio on PET/CT was calculated by dividing the maximum standardized uptake value of a primary lesion by the mean standardized uptake value of the normal liver...
May 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28291381/selimetry-a-multicentre-i-131-dosimetry-trial-a-clinical-perspective
#15
Jonathan Wadsley, Rebecca Gregory, Glenn Flux, Kate Newbold, Yong Du, Laura Moss, Andrew Hall, Louise Flanagan, Sarah R Brown
Treatment options for patients with thyroid cancer that is no longer sensitive to iodine therapy are limited. Those treatments which currently exist are associated with significant toxicity. The SELIMETRY trial (EudraCT No 2015-002269-47) aims to investigate the role of the MEK inhibitor Selumetinib in re-sensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy. Patients deemed to have sufficient iodine uptake in previously iodine refractory lesions after 4 weeks of Selumetinib therapy will be given an empirical activity of 5...
March 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28291010/ectopic-pelvic-kidney-mimicking-sacral-metastasis-on-post-therapy-iodine-131-scan-of-a-thyroid-cancer-patient
#16
Selin Soyluoğlu Demir, Gül Ege Aktaş, Ahmet Polat, Ali Sarıkaya
A 25-year-old woman had total thyroidectomy and iodine-131 ablation therapy for papillary thyroid carcinoma. Whole body imaging on the 7(th) day of therapeutic activity demonstrated radioiodine uptake in the remnant tissue and intense heterogeneous uptake at the sacral region prominently in the posterior image. Initial interpretation was suspicious for sacral metastasis. Technetium-99m-methylene diphosphonate bone scan demonstrated normal bone uptake and the absence of left kidney. On blood-pool phase of bone scan, the absence of left renal activity and an extra area of uptake in the sacral region suggestive of pelvic kidney were noticed...
February 5, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28283939/high-dose-of-radioactive-iodine-per-se-has-no-effect-on-glucose-metabolism-in-thyroidectomized-rats
#17
Roghaieh Samadi, Mahboubeh Ghanbari, Babak Shafiei, Sevda Gheibi, Fereidoun Azizi, Asghar Ghasemi
PURPOSE: Thyroid concentrates radioactive iodine by sodium-iodide symporter; this is used for treating hyperthyroidism and thyroid cancer. Pancreas expresses NIS and radioactive iodine uptake may damage pancreatic beta-cells and predispose patients to type 2 diabetes. The aim of this study was to determine whether radioactive iodine is associated with glucose metabolism in thyroidectomized rats. METHODS: Forty male Wistar rats were divided into four groups (n = 10/each); control, thyroidectomized, thyroidectomized-treated with 131-I (TX+I), and thyroidectomized-treated with 131-I and L-thyroxine (TX+I+T4)...
May 2017: Endocrine
https://www.readbyqxmd.com/read/28279069/brain-and-organ-uptake-in-the-rhesus-monkey-in-vivo-of-recombinant-iduronidase-compared-to-an-insulin-receptor-antibody-iduronidase-fusion-protein
#18
Ruben J Boado, William M Pardridge
Mucopolysaccharidosis type I (MPSI) is caused by mutations in the gene encoding the lysosomal enzyme, α-l-iduronidase (IDUA), and patients with MPSI are currently treated with IDUA enzyme replacement therapy (ERT). However, the majority of MPSI patients have severe CNS involvement, and conventional ERT does not treat the brain. The failure of ERT to treat the brain is believed to be due to the lack of IDUA transport through the blood-brain barrier (BBB). However, BBB transport of IDUA has not been directly measured, to date...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28271395/comparing-pre-therapeutic-124-i-and-131-i-uptake-tests-with-intra-therapeutic-131-i-uptake-in-benign-thyroid-disorders
#19
Falk Gühne, Christian Kühnel, Martin Freesmeyer
PURPOSE: (124)I-PET/CT can be used for pre-therapeutic assessment of radioactive iodine uptake in benign thyroid disorders, however systematic comparisons with intra-therapeutic uptake are still lacking for these disorders. The goals of this study were to compare (124)I RAIU and conventional (131)I RAIU tests with each other; to compare both tests with intra-therapeutic uptake (reference); and to verify the time course of radioactive iodine uptake at three time points (30, 102, and 336 h [14 days] post administration; p...
March 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28265612/ultrahigh-volatile-iodine-uptake-by-hollow-microspheres-formed-from-a-heteropore-covalent-organic-framework
#20
Zhi-Jian Yin, Shun-Qi Xu, Tian-Guang Zhan, Qiao-Yan Qi, Zong-Quan Wu, Xin Zhao
We herein report the construction of a new heteropore COF which consists of two different kinds of micropores with unprecedented shapes. It exists as hollow microspheres and exhibits an extremely high volatile iodine uptake (up to 481 wt%) by encapsulating iodine in the inner cavities and porous shells of the microspheres.
March 7, 2017: Chemical Communications: Chem Comm
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