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https://www.readbyqxmd.com/read/29927328/dual-energy-ct-iodine-mapping-and-40-kev-monoenergetic-applications-in-the-diagnosis-of-acute-bowel-ischemia
#1
Pedro D M Lourenco, Ryan Rawski, Mohammed F Mohammed, Faisal Khosa, Savvas Nicolaou, Patrick McLaughlin
OBJECTIVE: Sensitivity of CT of the abdomen for detection of acute bowel ischemia (ABI) can be as low as 60%. In this study, we assessed the diagnostic performance of iodine-map and monoenergetic (40-keV) images in patients with suspected ABI. MATERIALS AND METHODS: This retrospective study included 60 consecutive patients with suspected ABI who underwent a standardized imaging protocol dual-source dual-energy CT (DECT) over a 26-month period. Clinical and operative outcomes were recorded as the reference standard...
June 21, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29923634/radioimmunoimaging-and-targeting-treatment-in-an-immunocompetent-murine-model-of-triple-negative-breast-cancer-using-radiolabeled-anti-pd-l1-monoclonal-antibody
#2
Xiaoxi Pang, Meng Liu, Rongfu Wang, Xuhe Liao, Ping Yan, Chunli Zhang
The overall aim of this study was to evaluate whether iodine-131 radiolabeled monoclonal antibody (mAb) targeting PD-L1 can be used for imaging of PD-L1 expression noninvasively in vivo, and playing synergistic effect combined with immunotherapy. Anti-PD-L1 mAb was radiolabeled with iodine-131 (131 I-PD-L1 mAb), and was characterized in vitro. Biodistribution and imaging in vivo were performed periodically. Therapy study was conducted in triple-negative breast cancer bearing BALB/c mice. As results, the labeling efficiencies of 131 I-PD-L1 mAb reached 80 % ± 3 %, with radiochemical purity was 97 % ± 1 %...
June 20, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29914537/combination-therapy-of-ipilimumab-and-nivolumab-induced-thyroid-storm-in-a-patient-with-hashimoto-s-disease-and-diabetes-mellitus-a-case-report
#3
Kazuko Yonezaki, Toshihiro Kobayashi, Hitomi Imachi, Takuo Yoshimoto, Fumi Kikuchi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Nao Yamaji, Jingya Lyu, Tao Dong, Koji Murao
BACKGROUND: Recently, immune checkpoint inhibitors have widely been used for the management of advanced melanoma. However, high-grade immune-related adverse events can occur, particularly with combination immunotherapy. We report a case of a patient with melanoma who developed thyroid storm following treatment with ipilimumab and nivolumab. CASE PRESENTATION: An 85-year-old Japanese man with a history of malignant melanoma presented to our department with severe thyrotoxicosis and poor blood glucose control...
June 19, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29910159/nivolumab-induced-thyroid-dysfunction-in-patients-with-lung-cancer
#4
Ana M Ramos-Levi, Jacobo Rogado, Jose Miguel Sanchez-Torres, Ramón Colomer, Mónica Marazuela
BACKGROUND: Nivolumab is an anti-cancer monoclonal antibody that inhibits PD1 and modulates T-cell response. It has been shown to significantly improve survival in several types of cancer, but clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant. OBJECTIVE: To comprehensively evaluate the clinical presentation of endocrine IRAEs in patients with lung cancer treated with nivolumab...
June 14, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29908040/dual-energy-ct-for-noninvasive-staging-of-liver-fibrosis-accuracy-of-iodine-density-measurements-from-contrast-enhanced-data
#5
Keitaro Sofue, Masakatsu Tsurusaki, Achille Mileto, Tomoko Hyodo, Kosuke Sasaki, Tatsuya Nishii, Takaaki Chikugo, Norihisa Yada, Masatoshi Kudo, Kazuro Sugimura, Takamichi Murakami
AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy CT data can noninvasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (noncontrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29894335/evidence-of-prostate-specific-membrane-antigen-expression-in-metastatic-differentiated-thyroid-cancer-using-68ga-psma-hbed-cc-pet-ct
#6
Priyanka Verma, Gaurav Malhotra, Ritesh Agrawal, Sunita Sonavane, Vilas Meshram, Ramesh V Asopa
PURPOSE OF THE REPORT: Prostate-specific membrane antigen (PSMA) overexpression is not restricted to prostate cancer, but it has also been demonstrated in gliomas, lung cancer, and in tumor neovasculature. Systematic studies exploring PSMA uptake in thyroid tumors are lacking. The aim of this pilot study was to assess PSMA expression in patients with metastatic differentiated thyroid cancer (mDTC). MATERIALS AND METHODS: Ten patients of mDTC harboring 32 lesions (5 men; age range, 38-65 years; mean age, 50 years) underwent prospective evaluation with radioiodine (I), F-FDG PET, and Ga-PSMA-HBED-CC PET scans as per the institution protocol...
June 12, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29875930/pattern-of-presentation-of-graves-disease-and-response-to-radioiodine-therapy-in-south-african-men
#7
Yetunde Ajoke Onimode, David Magbagbeola Dairo, Annare Ellmann
Introduction: Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0.7 per 100, 000 has been reported for South African men while the women have a relatively higher rate of 0.02. There is no documented evidence between male and female genders in response to treatment of PH with radioactive iodine (RAI), although operational evidence suggests that hyperthyroidism in males is less amenable to RAI treatment (RAIT) than females...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29866349/what-is-the-underestimation-of-radiation-dose-to-the-pediatric-thyroid-gland-from-contrast-enhanced-ct-if-contrast-medium-uptake-is-not-taken-into-account
#8
Kostas Perisinakis, Styliani Pouli, Antonis Tzedakis, Kostas Spanakis, Adam Hatzidakis, Maria Raissaki, John Damilakis
PURPOSE: To assess the underestimation of radiation dose to the thyroid of children undergoing contrast enhanced CT if contrast medium uptake is not taken into account. METHODS: 161 pediatric head, head & neck and chest CT examinations were retrospectively studied to identify those involving pre- and post-contrast imaging and thyroid inclusion in imaged volume. CT density of thyroid tissue in HU was measured in non-enhanced (NECT) and corresponding contrast-enhanced CT (CECT) images...
May 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29848690/amyloid-beta-interactions-with-abc-transporters-and-resistance-modifiers
#9
Joseph Molnar, Imre Ocsovszki, Rozalia Pusztai
BACKGROUND/AIM: Failure of cancer chemotherapy caused by multidrug resistance (MDR) of tumor cells is mediated by ABC transporters that reduce the uptake of cytotoxic agents. Similar transporters are responsible for amyloid clearance in nerve cells in Alzheimer's disease (AD). The aim of this study was to compare the biological effects of amyloid complexes of some known ABC transporter inhibitors e.g. disiloxanes. One of the most active fragments of the pathological "endogen" substrate responsible for AD was investigated in the presence of amyloid-beta fragment on the reversal of multidrug resistance and apoptosis induction on multidrug-resistant tumor cells in model experiments...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29846997/remarkable-effect-of-halogen-substitution-on-the-membrane-transport-of-fluorescent-molecules-in-living-cells
#10
Harinarayana Ungati, Vijayakumar Govindaraj, Govindasamy Mugesh
Small-molecule-based fluorescent probes have become important tools in biology for sensing and imaging applications. However, the biological applications of many of the fluorescent molecules are hampered by low cellular uptake and high toxicity. In this paper, we show for the first time that the introduction of halogen atoms enhances the cellular uptake of fluorescent molecules and the nature of halogen atoms plays a crucial role in the plasma membrane transport in mammalian cells. The remarkably higher uptake of iodinated compounds as compared to that of their chloro or bromo analogues suggests that the strong halogen bonding ability of iodine atoms may play an important role in the membrane transport...
May 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29808428/improved-detection-rates-and-treatment-planning-of-head-and-neck-cancer-using-dual-layer-spectral-ct
#11
Fabian K Lohöfer, Georgios A Kaissis, Frances L Köster, Sebastian Ziegelmayer, Ingo Einspieler, Carlos Gerngross, Michael Rasper, Peter B Noel, Steffen Koerdt, Andreas Fichter, Ernst J Rummeny, Rickmer F Braren
PURPOSE: The aim of this study was to evaluate the advantages of dual-layer spectral CT (DLSCT) in detection and staging of head and neck cancer (HNC) as well as the imaging of tumour margins and infiltration depth compared to conventional contrast enhanced CT (CECT). MATERIALS AND METHODS: Thirty-nine patients with a proven diagnosis of HNC were examined with a DLSCT scanner and retrospectively analysed. An age-matched healthy control group of the same size was used...
May 28, 2018: European Radiology
https://www.readbyqxmd.com/read/29806216/exceptional-iodine-capture-in-2d-covalent-organic-frameworks
#12
Ping Wang, Qing Xu, Zhongping Li, Weiming Jiang, Qiuhong Jiang, Donglin Jiang
Progress in chemistry over the past four decades has generated a variety of porous materials for removing iodine-a radioactive emission accompanying nuclear fission. However, most studies are still based on the notion that entangled pores together with specific binding sites are essential for iodine capture. Here, an unraveled physical picture of iodine capture that overturns the preconception by exploring 1D channeled porous materials is disclosed. 2D covalent organic frameworks are constructed in a way so that they are free of interpenetration and binding sites but consist of 1D open channels...
May 28, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29788716/porous-silsesquioxane-imine-frameworks-as-highly-e%C3%AF-cient-adsorbents-for-cooperative-iodine-capture
#13
Mateusz Janeta, Wojciech Bury, Slawomir Szafert
The efficient capture and storage of radioactive iodine (129 I or 131 I), which can be formed during nuclear energy generation or storage of nuclear waste, is of paramount importance. Herein we present highly efficient aerogels for reversible iodine capture, namely Porous Silsesquioxane-Imine Frameworks (PSIF), constructed by a condensation of octa(3-aminopropyl)silsesquioxane cage compound (OAS-POSS) and selected multitopic aldehydes. The resulting PSIFs are permanently porous (Brunauer-Emmet-Teller (BET) surface areas up to 574 m2 /g), thermally stable and present a combination of micro-, meso- and macropores in their structures...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29777899/congenital-dyshormonogenic-hypothyroidism-with-goiter-caused-by-a-sodium-iodide-symporter-slc5a5-mutation-in-a-family-of-shih-tzu-dogs
#14
E A Soler Arias, V A Castillo, J D Garcia, J C Fyfe
An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. The only sign of hypothyroidism was a moderate growth delay in the adult dog. The ITD was recognized by the absence of uptake of technetium-99m in the salivary glands (sg) and goiter observed by scintigraphy. In the same scan, radiopharmaceutical uptake was found in the anterior mediastinum of both dogs and in the right axillary lymph node in the oldest dog...
April 24, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29774382/iodine-material-density-images-in-dual-energy-ct-quantification-of-contrast-uptake-and-washout-in-hcc
#15
Daniela Pfeiffer, Anushri Parakh, Manuel Patino, Avinash Kambadakone, Ernst J Rummeny, Dushyant V Sahani
PURPOSE: To determine the diagnostic potential of Material Density (MD) iodine images in dual-energy CT (DECT) for visualization and quantification of arterial phase hyperenhancement and washout in hepatocellular carcinomas compared to magnetic resonance imaging (MRI). MATERIALS AND METHODS: The study complied with HIPAA guidelines and was approved by the ethics committee of the institutional review board. Thirty-one patients (23 men, 8 women; age range, 36-87 years) with known or suspected Hepatocellular Carcinoma (HCC) were included...
May 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29766683/star-shaped-intense-uptake-of-%C3%A2-%C3%A2-%C3%A2-i-on-whole-body-scans-can-reflect-good-therapeutic-effects-of-low-dose-radioactive-iodine-treatment-of-1-1-gbq
#16
Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
BACKGROUND: After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of ¹³¹I on whole body scans (WBSs), called a 'star artifact.' We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis. METHODS: Total 636 patients who received ¹³¹I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766463/predictive-factors-for-the-outcomes-of-initial-i-131-low-dose-ablation-therapy-to-japanese-patients-with-differentiated-thyroid-cancer
#17
Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa
OBJECTIVE: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). PATIENTS AND METHODS: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks...
May 15, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29762693/influence-of-feeding-thermally-peroxidized-soybean-oil-to-finishing-barrows-on-processing-characteristics-and-shelf-life-of-commercially-manufactured-bacon
#18
M F Overholt, J E Lowell, G D Kim, D D Boler, B J Kerr, A C Dilger
Objectives were to evaluate effects of feeding soybean oil (SO) with varying levels of peroxidation on fresh belly characteristics, processing yields, and shelf life of commercially manufactured bacon stored under food-service style conditions. Fifty-six barrows were randomly assigned to 1 of 4 diets containing 10% fresh SO (22.5°C) or thermally processed SO (45°C for 288 h, 90°C for 72 h, or 180°C for 6 h), each infused with air at a rate of 15L/min. Individually housed pigs were provided ad libitum access to feed for 81 d...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29761277/treatment-of-differentiated-thyroid-cancer-can-endoscopic-thyroidectomy-via-a-chest-breast-approach-achieve-similar-therapeutic-effects-as-open-surgery
#19
Rui Qu, Jinyi Li, Jingge Yang, Peng Sun, Jian Gong, Cunchuan Wang
BACKGROUND: An analysis of some special factors was performed to further evaluate and discuss whether endoscopic surgery and traditional open surgery have similar therapeutic outcomes for differentiated thyroid cancer (DTC). METHODS: A retrospective study was performed on 76 patients undergoing surgery to treat DTC. Forty patients were treated by endoscopic thyroidectomy via the chest-breast approach (endoscopic group) and thirty-six patients were treated by open surgery (open group)...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29759035/a-novel-missense-mutation-in-slc5a5-gene-in-a-sudanese-family-with-congenital-hypothyroidism
#20
Yui Watanabe, Reham Shareef Ebrhim, Mohamed A Abdullah, Roy E Weiss
Thyroid hormone synthesis requires the presence of iodide. The sodium iodide symporter (NIS) is a glycoprotein which mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). The proposita is a 28-year-old female whose origin is the North Sudan where neonatal screening for CH is not available. She presented with severe constipation and a goiter at the age of 40 days. Laboratory testing confirmed CH and she was started on levothyroxine (L-T4)...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
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