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https://www.readbyqxmd.com/read/28635633/new-insights-in-thyroid-cancer-and-p53-family-proteins
#1
REVIEW
Livia Manzella, Stefania Stella, Maria Stella Pennisi, Elena Tirrò, Michele Massimino, Chiara Romano, Adriana Puma, Martina Tavarelli, Paolo Vigneri
Thyroid cancers are common endocrine malignancies that comprise tumors with different clinical and histological features. Indeed, papillary and follicular thyroid cancers are slow-growing, well-differentiated tumors, whereas anaplastic thyroid cancers are undifferentiated neoplasias that behave much more aggressively. Well-differentiated thyroid carcinomas are efficiently cured by surgery and radioiodine, unlike undifferentiated tumors that fail to uptake radioactive iodine and are usually resistant to chemotherapy...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28626553/stepwise-crystallographic-visualization-of-dynamic-guest-binding-in-a-nanoporous-framework
#2
Gabriel Brunet, Damir A Safin, Mohammad Z Aghaji, Koen Robeyns, Ilia Korobkov, Tom K Woo, Muralee Murugesu
Binding sites are at the heart of all host-guest systems, whether biological or chemical. When considering binding sites that form covalent bonds with the guest, we generally envision a single, highly specific binding motif. Through single-crystal X-ray crystallography, the dynamic binding of a guest that displays a variety of covalent binding motifs in a single site of adsorption is directly observed for the first time. The stepwise crystallographic visualization of the incorporation of I2 within a porous MOF is presented, wherein the preferred binding motifs throughout the uptake process are identified...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28618195/novel-reductive-dehalogenases-from-the-marine-sponge-associated-bacterium-desulfoluna-spongiiphila
#3
Jie Liu, Nora Lopez, Young-Beom Ahn, Tatyana Goldberg, Yana Bromberg, Lee J Kerkhof, Max M Häggblom
Desulfoluna spongiiphila strain AA1 is an organohalide respiring bacterium, isolated from the marine sponge Aplysina aerophoba, that can use brominated and iodinated phenols, in addition to sulfate and thiosulfate as terminal electron acceptors. The genome of Desulfoluna spongiiphila strain AA1 is approximately 6.5 Mb. Three putative reductive dehalogenase (rdhA) genes involved in respiratory metabolism of organohalides were identified within the sequence. Conserved motifs found in respiratory reductive dehalogenases (a twin arginine translocation signal sequence and two iron-sulfur clusters) were present in all three putative AA1 rdhA genes...
June 15, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28616978/synthesis-and-pre-clinical-characterization-of-a-cationic-iodinated-imaging-contrast-agent-ca4-and-its-use-for-quantitative-computed-tomography-of-ex-vivo-human-hip-cartilage
#4
Rachel C Stewart, Amit N Patwa, Hrvoje Lusic, Jonathan D Freedman, Michel Wathier, Brian D Snyder, Ali Guermazi, Mark W Grinstaff
Contrast agents that go beyond qualitative visualization and enable quantitative assessments of functional tissue performance represent the next generation of clinically useful imaging tools. An optimized and efficient large-scale synthesis of the cationic iodinated contrast agent (CA4+) is described for imaging articular cartilage. Contrast enhanced CT (CECT) using CA4+ reveals significantly greater agent uptake of CA4+ in articular cartilage compared to similar anionic or nonionic agents, and CA4+ uptake follows Donnan Equilibrium...
June 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28613103/quantification-of-igg-monoclonal-antibody-clearance-in-tissues
#5
Miro J Eigenmann, Ludivine Fronton, Hans Peter Grimm, Michael B Otteneder, Ben-Fillippo Krippendorff
Monoclonal antibodies are an important therapeutic entity, and knowledge of antibody pharmacokinetics has steadily increased over the years. Despite this effort, little is known about the extent of IgG antibody degradation in different tissues of the body. While studies have been published identifying sites of degradation with the use of residualizing and non-residualizing radiolabels, quantitative tissue clearances have not yet been derived. Here, we show that in physiologically-based pharmacokinetic (PBPK) models we can combine mouse data of Indium-111 and Iodine-125 labeled antibodies with prior physiological knowledge to determine tissue-specific intrinsic clearances...
June 14, 2017: MAbs
https://www.readbyqxmd.com/read/28608961/high-affinity-click-rgd-peptidomimetics-as-radiolabeled-probes-for-imaging-%C3%AE-v%C3%AE-3-integrin
#6
Monica Piras, Andrea Testa, Ian N Fleming, Sergio Dall'Angelo, Alexandra Andriu, Sergio Menta, Mattia Mori, Gavin D Brown, Duncan Forster, Kaye J Williams, Matteo Zanda
Non-peptidic RGD-mimic ligands were designed and synthesized by click chemistry between an arginine-azide mimic and an aspartic acid-alkyne mimic. Some of these molecules combine excellent in vitro properties (high αvβ3 affinity, selectivity, drug-like logD, high metabolic stability) with a variety of radiolabeling options (e.g. tritium and [18F]fluorine, plus compatibility with radio-iodination), not requiring the use of chelators or prosthetic groups. The binding mode of the resulting triazole RGD-mimics to αvβ3 or αIIbβ3 receptors was investigated by molecular modeling simulations...
June 13, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28591728/generation-and-evaluation-of-antibody-agents-for-molecular-imaging-of-cd44v6-expressing-cancers
#7
Anna-Karin Haylock, Johan Nilvebrant, Anja Mortensen, Irina Velikyan, Marika Nestor, Ronny Falk
AIM: The aim of this study was to generate and characterize scFv antibodies directed to human CD44v6, as well as to radiolabel and evaluate top candidates in vitro and in vivo for their potential use in CD44v6-targeted molecular imaging in cancer patients. MATERIALS AND METHODS: Phage display selections were used to isolate CD44v6-specific scFvs. A chain shuffling strategy was employed for affinity maturation based on a set of CD44v6-specific first-generation clones...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28581558/effects-of-halogens-on-european-air-quality
#8
T Sherwen, M J Evans, R Sommariva, L D J Hollis, S M Ball, P S Monks, C Reed, L J Carpenter, J D Lee, G Forster, B Bandy, C E Reeves, W J Bloss
Halogens (Cl, Br) have a profound influence on stratospheric ozone (O3). They (Cl, Br and I) have recently also been shown to impact the troposphere, notably by reducing the mixing ratios of O3 and OH. Their potential for impacting regional air-quality is less well understood. We explore the impact of halogens on regional pollutants (focussing on O3) with the European grid of the GEOS-Chem model (0.25° × 0.3125°). It has recently been updated to include a representation of halogen chemistry. We focus on the summer of 2015 during the ICOZA campaign at the Weybourne Atmospheric Observatory on the North Sea coast of the UK...
June 5, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28570876/novel-n-rich-porous-organic-polymers-with-extremely-high-uptake-for-capture-and-reversible-storage-of-volatile-iodine
#9
Xin Qian, Bing Wang, Zhao-Qi Zhu, Han-Xue Sun, Feng Ren, Peng Mu, Chonghua Ma, Wei-Dong Liang, An Li
The imino group-contained porous organic polytriphenylamine, which originated from diphenylamine and 1,3,5-tris(4-bromophenyl)benzene, was designedly synthesized though Buchwald-Hartwig coupling reaction. The basic properties including morphologies, structure and thermal stability of the resulting POPs were investigated by scanning electron microscope(SEM), thermo gravimeter analysis (TGA), (13)C CP/MAS solid state NMR and Fourier transform infrared spectroscope (FTIR). The pore size distribution of POPs present uniform mesoporous of sizes less than 50nm...
May 24, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28569635/thyrotoxicosis-induced-by-excessive-3-5-3-triiodothyronine-in-a-dog
#10
Wendy A Morré, David L Panciera, Gregory B Daniel, Kent R Refsal, Markus Rick, Kathy Arrington
CASE DESCRIPTION A 7-year-old castrated male Havanese was evaluated at a veterinary teaching hospital because of a 12-week history of hyperactivity, aggression, and progressive weight loss despite a healthy appetite. CLINICAL FINDINGS Tachycardia was the only remarkable finding during physical examination. Serum 3,5,3'-triiodothyronine (T3) and free T3 concentrations were markedly increased, and thyroxine (T4), free T4, and thyroid-stimulating hormone concentrations were at or decreased from the respective reference ranges...
June 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28567292/euthyroid-athyroxinemia-a-novel-endocrine-syndrome
#11
Nicholas Woodhouse, Fatima Bahowairath, Omayma Elshafie
A 55-year-old female was referred with abnormal thyroid function tests (TFTs); the free thyroxine level (FT4) was undetectable <3.3 pmol/L (normal: 7.9-14.4), while her FT3, TSH and urinary iodine levels were normal. She was clinically euthyroid with a large soft lobulated goitre that had been present for more than thirty years. She received an injection of recombinant human TSH (rhTSH) following which there was a progressive rise of the FT3 and TSH levels to 23 pmol/L and >100 mIU/L respectively at 24 h, The FT4 however remained undetectable throughout...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28551882/medical-geology-of-endemic-goiter-in-kalutara-sri-lanka-distribution-and-possible-causes
#12
G W A R Fernando, P L C L Liyanage, Anushka Upamali Rajapaksha, Meththika Vithanage
This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28550173/experimental-cardiac-radiation-exposure-induces-ventricular-diastolic-dysfunction-with-preserved-ejection-fraction
#13
Hirofumi Saiki, Gilles Moulay, Adam J Guenzel, Weibin Liu, Teresa Decklever, Kelly Classic, Linh Pham, Horng H Chen, John C Burnett, Stephen J Russell, Margaret M Redfield
BACKGROUND: Breast cancer radiotherapy increases the risk of heart failure (HF) with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radio-resistant but radiation specifically affects coronary microvascular endothelial cells with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28522155/fibroelastic-pseudotumour-elastofibroma-dorsi-detected-by-18-f-fdg-pet-ct-and-by-posttherapy-radioiodine-spect-ct
#14
M Oporto, F Cepa, N Orta, S Rubí, H Navalón, C Peña
Radioiodine uptake in the thyroid tissue, metastasis of differentiated thyroid cancer (DTC), and in other tissues, depends on the expression of sodium-iodide symporter (NIS). Vascular permeability, effusions, inflammation, and other mechanisms may also play a role in the accumulation of radioactive iodine. A 63-year-old woman underwent radioiodine therapy, as well as a post-therapy whole-body scan,as she was suspected of having lung metastasis from thyroid carcinoma. The scan not only showed uptake at the lung metastasis but also a faint diffuse bilateral uptake in the posterior thorax...
May 15, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28506061/an-elastic-hydrogen-bonded-cross-linked-organic-framework-for-effective-iodine-capture-in-water
#15
Yunxiao Lin, Xuanfeng Jiang, Samuel T Kim, Sampath B Alahakoon, Xisen Hou, Zhiyun Zhang, Christina M Thompson, Ronald A Smaldone, Chenfeng Ke
A crystalline microporous hydrogen-bonded cross-linked organic framework has been developed through covalent photo-cross-linking of molecular monomers that are assembled in a crystalline state. The elastic framework expands its void space to adsorb iodine rapidly with a high uptake capacity in an aqueous environment as well as recovering its crystalline form after the release of iodine.
May 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28502167/transient-porosity-in-densely-packed-crystalline-carbazole-p-diethynylphenylene-carbazole-rotors-co2-and-acetone-sorption-properties
#16
Andrés Aguilar-Granda, Salvador Pérez-Estrada, Elı Sánchez-González, J Raziel Álvarez, Joelis Rodríguez-Hernández, Mario Rodríguez, Arian E Roa, Simón Hernández-Ortega, Ilich A Ibarra, Braulio Rodríguez-Molina
We report for the first time the high sorption properties of a molecular rotor with no permanent voids or channels in its crystal structure. Such crystalline phase originates from THF, DCM, or the irreversible desolvation of entrapped benzene molecules. From these, the benzene in its solvate form acts as rotation stopper, as supported by dynamic characterization using solid-state (2)H NMR experiments. In the solvent-free form, the diffusion of small quantities of iodine vapors caused a significant change in the intramolecular rotation, increasing the known activation energy to rotation from 8...
June 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28479864/chemisorption-of-iodine-125-to-gold-nanoparticles-allows-for-real-time-quantitation-and-potential-use-in-nanomedicine
#17
Adrian A Walsh
Gold nanoparticles have been available for many years as a research tool in the life sciences due to their electron density and optical properties. New applications are continually being developed, particularly in nanomedicine. One drawback is the need for an easy, real-time quantitation method for gold nanoparticles so that the effects observed in in vitro cell toxicity assays and cell uptake studies can be interpreted quantitatively in terms of nanoparticle loading. One potential method of quantifying gold nanoparticles in real time is by chemisorption of iodine-125, a gamma emitter, to the nanoparticles...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28479268/progression-of-myocardial-sympathetic-denervation-assessed-by-123-i-mibg-imaging-in-familial-amyloid-polyneuropathy-and-the-effect-of-liver-transplantation
#18
Maria da Conceição Azevedo Coutinho, Nuno Cortez-Dias, Guilhermina Cantinho, Isabel Conceição, Tatiana Guimarães, Gustavo Lima da Silva, Miguel Nobre Menezes, Ana Rita Francisco, Rui Plácido, Fausto J Pinto
INTRODUCTION: Familial amyloid polyneuropathy (FAP) is a rare disease caused by systemic deposition of amyloidogenic variants of the transthyretin (TTR) protein. The TTR-V30M mutation is caused by the substitution of valine by methionine at position 30 and mainly affects the peripheral and autonomic nervous systems. Cardiovascular manifestations are common and are due to autonomic denervation and to amyloid deposition in the heart. Cardiac sympathetic denervation detected by iodine-123 labeled metaiodobenzylguanidine (MIBG) is an important prognostic marker in TTR-V30M FAP...
May 4, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28470585/evaluation-of-radioiodinated-1-4-naphthoquinones-as-necrosis-avid-agents-for-rapid-myocardium-necrosis-imaging
#19
Chang Su, Dongjian Zhang, Na Bao, Aiyan Ji, Yuanbo Feng, Li Chen, Yicheng Ni, Jian Zhang, Zhiqi Yin
PURPOSE: Identifying necrotic myocardium in ischemic regions is of great importance for risk stratification and clinical decision-making. However, rapid noninvasive imaging of necrotic myocardium is still challenging. This study sought to evaluate the potential of 1,4-naphthoquinones to rapidly visualize necrotic myocardium and the possible mechanisms of necrosis avidity. PROCEDURES: Six 1,4-naphthoquinones were radiolabeled with iodine-131 and the necrosis avidity was estimated in mouse models with muscular necrosis by gamma counting and autoradiography...
May 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28470402/systematic-radiation-dose-optimization-of-abdominal-dual-energy-ct-on-a-second-generation-dual-source-ct-scanner-assessment-of-the-accuracy-of-iodine-uptake-measurement-and-image-quality-in-an-in-vitro-and-in-vivo-investigations
#20
Sebastian T Schindera, Caroline Zaehringer, Luigia D Errico, Fides Schwartz, Maka Kekelidze, Zsolt Szucs-Farkas, Matthias R Benz
PURPOSE: To assess the accuracy of iodine quantification in a phantom study at different radiation dose levels with dual-energy dual-source CT and to evaluate image quality and radiation doses in patients undergoing a single-energy and two dual-energy abdominal CT protocols. METHODS: In a phantom study, the accuracy of iodine quantification (4.5-23.5 mgI/mL) was evaluated using the manufacturer-recommended and three dose-optimized dual-energy protocols. In a patient study, 75 abdomino-pelvic CT examinations were acquired as follows: 25 CT scans with the manufacturer-recommended dual-energy protocol (protocol A); 25 CT scans with a dose-optimized dual-energy protocol (protocol B); and 25 CT scans with a single-energy CT protocol (protocol C)...
May 3, 2017: Abdominal Radiology
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