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https://www.readbyqxmd.com/read/27904869/value-of-dedicated-head-and-neck-18-f-fdg-pet-ct-protocol-in-detecting-recurrent-and-metastatic-lesions-in-post-surgical-differentiated-thyroid-carcinoma-patients-with-high-serum-thyroglobulin-level-and-negative-131-i-whole-body-scan
#1
Mai Hong Son, Bui Quang Bieu, Le Ngoc Ha
OBJECTIVES: In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative (131)I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of (18)F-FDG PET/CT scan in DTC patients with high serum Tg level and negative (131)I WBS. METHODS: 69 post-surgical DTC patients with high serum Tg level and negative post ablation (131)I WBS were enrolled in this study...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27898646/iodine-123-metaiodobenzylguanidine-scintigraphy-for-the-assessment-of-cardiac-sympathetic-innervation-and-the-relationship-with-cardiac-autonomic-function-in-healthy-adults-using-standardized-methods
#2
Omar Asghar, Parthiban Arumugam, Ian Armstrong, Simon Ray, Matthias Schmitt, Rayaz A Malik
BACKGROUND: Global iodine-123 metaiodobenzylguanidine (I-MIBG) uptake is predictive of cardiovascular events and mortality in patients with heart failure. Normal variations in global and regional uptake, however, are not well defined and few studies have addressed the functional relevance of I-MIBG uptake and distribution in healthy individuals. MATERIALS AND METHODS: We performed I-MIBG scintigraphy and cardiac autonomic function testing using the standardized methodology in 15 healthy individuals (mean age 54...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27863957/ex-vivo-complexation-skin-permeation-interaction-and-cytodermal-toxicity-studies-of-p-tertbutylcalix-4-arene-nanoemulsion-for-radiation-decontamination
#3
Navneet Sharma, Himanshu Ojha, Dharam Pal Pathak, Rajeev Goel, Rakesh Kumar Sharma
AIMS: p-Tertbutylcalix [4]arene loaded nanoemulsion has been designed, characterized and evaluated for skin decontamination of radionuclides of interest in nuclear and radiological emergencies. Further, nanoemulsion was evaluated for Ex-vivo complexation, skin permeation, interaction and cytodermal toxicity. MATERIALS AND METHODS: Ex-vivo skin complexation studies were conducted using High-resolution sector field inductively coupled plasma mass spectroscopy (HR-SF-ICPMS)...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27861299/impact-of-concomitant-medication-use-on-myocardial-123i-mibg-imaging-results-in-patients-with-heart-failure
#4
Arnold F Jacobson, Susan White, Mark I Travin, Carol Tseng
INTRODUCTION: Medications that interfere with sympathetic neuronal norepinephrine uptake and storage, such as neuropsychiatrics (NP) and sympathomimetic amines, are most likely to affect cardiac uptake of iodine-123 metaiodobenzylguanidine (I-mIBG). The present study examined these and other medications reported to affect I-mIBG uptake using measurements of cardiac I-mIBG uptake on the heart failure (HF) patients in the ADMIRE-HF extension (X) study. METHODS: Baseline concomitant medications taken by the 961 HF patients were categorized into five groups: calcium channel blockers, NP medications, β agonists and sympathomimetics, α antagonists, and other antihypertensives...
November 16, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27853073/feminizing-adrenocortical-carcinoma-with-distinct-histopathological-findings
#5
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27846003/imaging-of-prostate-specific-membrane-antigen-expression-in-metastatic-differentiated-thyroid-cancer-using-68ga-hbed-cc-psma-pet-ct
#6
Susanne Lütje, Benedikt Gomez, Joseph Cohnen, Lale Umutlu, Martin Gotthardt, Thorsten D Poeppel, Andreas Bockisch, Sandra Rosenbaum-Krumme
PURPOSE: The prostate-specific membrane antigen (PSMA) was shown to be overexpressed on the neovasculature of several malignancies. Here, the role of Ga-HBED-CC-PSMA PET/CT for the detection of PSMA expression in patients with metastasized differentiated thyroid cancer (DTC) was evaluated. METHODS: Six patients with iodine-negative and F-FDG-positive metastasized DTC (mean TG, 1616 ng/mL) received 71-93 MBq of the Ga-labeled PSMA ligand and underwent PET/CT at 62 ± 7 minutes p...
November 11, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27829313/taz-induction-directs-differentiation-of-thyroid-follicular-cells-from-human-embryonic-stem-cells
#7
Risheng Ma, Syed Morshed, Rauf Latif, Terry F Davies
OBJECTIVE: The differentiation program for human thyroid follicular cells (TFCs) relies on the interplay between sequence-specific transcription factors and transcriptional co-regulators. TAZ (transcriptional co-activator with PDZ-binding motif) is a co-activator that regulates several transcription factors, including PAX8 and NKX2-1, which play a central role in thyroid-specific gene transcription. TAZ and PAX8/NKX2-1 are co-expressed in the nuclei of thyroid cells and TAZ interacts directly with both PAX8 and NKX2-1 leading to their enhanced transcriptional activity on the thyroglobulin (TG) promoter and additional genes...
November 9, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27824968/an-intrapericardial-ectopic-thyroid-mimicking-metastasis-in-a-patient-with-papillary-thyroid-cancer-localization-differential-diagnosis-by-18-f-fdg-pet-ct-and-ablation-by-131-i
#8
Seol Hoon Park, Minjung Seo, Tae Young Park, Seong Nam-Goong
We report a very rare case of incidental intrapericardial thyroid in a papillary thyroid cancer patient. Post ablation scan revealed iodine-131 ((131)I) uptake in the mid-chest. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed and showed a (18)F-FDG avid lesion between the right atrium and the ascending aorta, (which was) shown tube an ectopic thyroid and not metastasis. The lesion disappeared on a 6 month follow-up (123)I whole body scan while serum thyroglobulin was negative...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27813621/incidental-thyroid-99mtc-mdp-uptake-in-a-patient-affected-by-differentiated-thyroid-cancer
#9
Domenico Albano, Gian Carlo Magri, Giorgio Treglia, Francesco Bertagna
We report a case of incidental uptake of 99mTc-methylene diphosphonate in the thyroid in a 62-year-old female with a history of breast cancer treated with quadrantectomy, chemotherapy and radiotherapy, who underwent total-body-bone scintigraphy during follow up. Planar scintigraphy was followed by neck SPECT-CT that demonstrated an area of increased tracer uptake in the neck at the left lobe of the thyroid. Neck ultrasonography showed a nodule corresponding to SPECT-CT finding and the ultrasound-guided fine needle aspiration documented the presence of papillary carcinoma...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27801741/extrathyroidal-radioiodine-accumulation-in-a-fibroadenoma-of-the-breast
#10
Myoung Hyoun Kim, Hun Soo Kim, Soon-Ah Park
A 45-year-old woman with a differentiated thyroid carcinoma received adjuvant radioiodine therapy following total thyroidectomy and left modified radical neck dissection. A posttherapy planar radioiodine scan showed multifocal uptake in the thyroid bed and left chest. SPECT/CT revealed a fibroadenoma in the left breast. Six months later, an I scan showed no iodine avidity in the breast fibroadenoma, whereas ultrasonography showed no significant change in the size of the fibroadenoma. Altered radioiodine uptake of a breast fibroadenoma can be observed on follow-up scans after cytotoxic radioiodide treatment in patients with differentiated thyroid carcinoma...
October 31, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27796544/the-intensity-of-18fdg-uptake-does-not-predict-tumor-growth-in-patients-with-metastatic-differentiated-thyroid-cancer
#11
Marie Terroir, Isabelle Borget, François Bidault, Marcel Ricard, Frédéric Deschamps, Dana Hartl, Lambros Tselikas, Laurent Dercle, Jean Lumbroso, Eric Baudin, Amandine Berdelou, Désirée Deandreis, Martin Schlumberger, Sophie Leboulleux
PURPOSE: In patients with metastatic differentiated thyroid carcinoma (DTC), fluorodeoxyglucose (FDG) uptake as well as age, tumor size and radioactive iodine (RAI) uptake are prognostic factors for survival. High FDG uptake is a poor prognostic factor and lesions with high FDG uptake are often considered aggressive, but the predictive value of FDG uptake for morphological progression is unknown. The principal aim of this retrospective single center study was to determine whether the intensity of FDG uptake was correlated on a per lesion analysis with tumor growth rate (TGR) expressed as the percentage of increase in tumor size during 1 year (1-year TGR)...
October 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27793633/use-of-177-lu-dotatate-in-the-treatment-of-iodine-refractory-thyroid-carcinomas
#12
P Oliván-Sasot, M Falgás-Lacueva, J García-Sánchez, V Vera-Pinto, C Olivas-Arroyo, P Bello-Arques
In a patient with a differentiated thyroid cancer the standard treatment protocol to be followed is surgery, ablation of thyroid remnants with (131)Iodine ((131)I), and TSH suppression. However, the treatment with (131)I is not effective in some cases, and it no longer becomes a therapeutic option due to cell de-differentiation with loss of (131)I uptake. Systemic treatment can be used as other options, although patients are not always responsive; thus, the disease may progress and therapeutic options may run out...
October 25, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27775934/ganglion-cyst-on-131i-whole-body-scintigraphy
#13
Anunita Khasgiwala, Kent P Friedman, Munir Ghesani, Roy A Raad
Interpretation of iodine I whole-body scintigraphy can be challenging, as there are many nonpathologic findings that may present with increased radiotracer uptake. Radiotracer uptake has been reported in the literature involving the salivary glands, thymus, renal cysts, skin contamination, and other benign etiologies. We present the case of an incidental right wrist ganglion cyst demonstrating persistent increased uptake on I whole-body scintigraphy.
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27752451/validation-data-for-the-determination-of-perchlorate-in-water-using-ion-chromatography-with-suppressed-conductivity-detection
#14
Maike A Seiler, Detlef Jensen, Udo Neist, Ursula K Deister, Franz Schmitz
BACKGROUND: Perchlorate salts are relatively stable, soluble in water, and migrate into groundwater sources. Groundwater is an essential source for drinking water suppliers. Perchlorate bears health risks as it is identified to impair normal thyroid function by interfering with iodine uptake by the thyroid gland. The development of a sensitive analytical method for the determination of perchlorate is therefore of the highest interest or public health. Ion chromatography is a sensitive method suitable for perchlorate determinations...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27721009/a-shape-memory-foam-composite-with-enhanced-fluid-uptake-and-bactericidal-properties-as-a-hemostatic-agent
#15
T L Landsman, T Touchet, S M Hasan, C Smith, B Russell, J Rivera, D J Maitland, E Cosgriff-Hernandez
: Uncontrolled hemorrhage accounts for more than 30% of trauma deaths worldwide. Current hemostatic devices focus primarily on time to hemostasis, but prevention of bacterial infection is also critical for improving survival rates. In this study, we sought to improve on current devices used for hemorrhage control by combining the large volume-filling capabilities and rapid clotting of shape memory polymer (SMP) foams with the swelling capacity of hydrogels. In addition, a hydrogel composition was selected that readily complexes with elemental iodine to impart bactericidal properties to the device...
October 6, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27709475/differentiated-thyroid-carcinoma-incremental-diagnostic-value-of-131-i-spect-ct-over-planar-whole-body-scan-after-radioiodine-therapy
#16
Valentina Zilioli, Alessia Peli, Maria Beatrice Panarotto, Giancarlo Magri, Ahmed Alkraisheh, Christiane Wiefels, Carlo Rodella, Raffaele Giubbini
The purpose of this prospective study was to determine the incremental diagnostic value of single photon emission computed tomography/computed tomography with iodine-131 over planar whole body scan in the staging of patients with differentiated thyroid carcinoma. A total of 365 patients (270 female, 95 male) with differentiated thyroid carcinoma were treated with radioiodine therapy for thyroid remnant ablation with radical intent after thyroidectomy between January 2013 and November 2014. In addition to planar whole body scan, single photon emission computed tomography/computed tomography of neck and chest were performed...
September 29, 2016: Endocrine
https://www.readbyqxmd.com/read/27689933/improved-in-vivo-stability-of-radioiodinated-rituximab-using-an-iodination-linker-for-radioimmunotherapy
#17
Eun Jung Kim, Byoung Soo Kim, Dan Bee Choi, Sung-Gil Chi, Tae Hyun Choi
PURPOSE: Directly radioiodinated [(131)I]-rituximab has been developed as a radioimmunotherapeutic agent in patients with CD20-positive B cell non-Hodgkin's lymphoma. However, there are concerns over its in vivo catabolism and deiodination. A novel radioiodination linker, N-(4-isothiocyanatobenzyl)-2-(3-(tributylstannyl)phenyl) acetamide (IBPA), was synthesized for the preparation of stable radioiodinated proteins. METHODS: The authors evaluated the potential of IBPA as a stable radioiodinated linker for rituximab...
September 30, 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27684811/identification-of-benign-and-malignant-thyroid-nodules-by-in-vivo-iodine-concentration-measurement-using-single-source-dual-energy-ct-a-retrospective-diagnostic-accuracy-study
#18
Shun-Yu Gao, Xiao-Yan Zhang, Wei Wei, Xiao-Ting Li, Yan-Ling Li, Min Xu, Ying-Shi Sun, Xiao-Peng Zhang
This study proposed to determine whether in vivo iodine concentration measurement by single-source dual energy (SSDE) CT can improve differentiation between benign and malignant thyroid nodules. In total, 53 patients presenting with thyroid nodules underwent SSDE CT scanning. Iodine concentrations were measured for each nodule and normal thyroid tissue using the GSI-viewer image analysis software. A total of 26 thyroid nodules were malignant in 26 patients and confirmed by surgery; 33 nodules from 27 patients were benign, with 10 confirmed by surgery and others after follow-up...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27678131/dual-energy-ct-allows-for-improved-characterization-of-response-to-antiangiogenic-treatment-in-patients-with-metastatic-renal-cell-cancer
#19
K Hellbach, A Sterzik, W Sommer, M Karpitschka, N Hummel, J Casuscelli, M Ingrisch, M Schlemmer, A Graser, Michael Staehler
OBJECTIVES: To evaluate the potential role of dual energy CT (DECT) to visualize antiangiogenic treatment effects in patients with metastatic renal cell cancer (mRCC) while treated with tyrosine-kinase inhibitors (TKI). METHODS: 26 patients with mRCC underwent baseline and follow-up single-phase abdominal contrast enhanced DECT scans. Scans were performed immediately before and 10 weeks after start of treatment with TKI. Virtual non-enhanced (VNE) and colour coded iodine images were generated...
September 27, 2016: European Radiology
https://www.readbyqxmd.com/read/27647872/early-detection-of-biochemically-occult-autonomous-thyroid-nodules
#20
Nunzia Brusca, Camilla Virili, Miriam Cellini, Silvia Capriello, Lucilla Gargano, Rita Salvatori, Marco Centanni, Maria Giulia Santaguida
OBJECTIVE: Autonomously functioning thyroid areas may be associated with subclinical or overt hyperthyroidism, but may exist even in the presence of normal TSH. This study was aimed at comparing the rate of autonomously functioning areas and their cardiac sequelae in patients with nodular goitre studied with the usual and a novel approach. DESIGN AND METHODS: A total of 490 adult outpatients with thyroid nodular goitre, living in a mild iodine-deficient area, were selected in our Referral Center for thyroid diseases from 2009 to 2014 on the basis of a suspicion of thyroid functional autonomy...
September 19, 2016: European Journal of Endocrinology
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