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https://www.readbyqxmd.com/read/29232183/loss-of-substantia-nigra-hyperintensity-at-3-0-t-mr-imaging-in-idiopathic-rem-sleep-behavior-disorder-comparison-with-123i-fp-cit-spect
#1
Yun Jung Bae, Jong-Min Kim, Kyeong Joon Kim, Eunhee Kim, Hyun Soo Park, Seo Young Kang, In-Young Yoon, Jee-Young Lee, Beomseok Jeon, Sang Eun Kim
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 and April 2015, 18 consecutively recruited patients with iRBD were evaluated with 3.0-T SW imaging and iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed tomography and compared with 18 healthy subjects and 18 patients with Parkinson disease (PD)...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29217738/radiolabeled-4-fluoro-3-iodobenzyl-guanidine-improves-imaging-and-targeted-radionuclide-therapy-of-norepinephrine-transporter-expressing-tumors
#2
Aiko Yamaguchi, Hirofumi Hanaoka, Tetsuya Higuchi, Yoshito Tsushima
Fluorine-18 (18F)/Iodine-131 (131I)-labeled (4-Fluoro-3-iodobenzyl)guanidine (FIBG) have been a promising yet unattainable derivative of radioiodine-labeled meta-iodobenzylguanidine (MIBG), because of the complex radiofluorination method. Here, we proposed a 2-step radiosynthetic method for 18F-FIBG, and evaluated the diagnostic and therapeutic potential of 18F-FIBG and 131I-FIBG in a pheochromocytoma model (PC-12). Methods:18F-FIBG was prepared from a (mesityl)(aryl)iodonium salt precursor in the presence of a copper-catalyst...
December 7, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29200191/determination-of-thresholds-of-radioactive-iodine-uptake-response-with-clinical-exposure-to-perchlorate-a-pooled-analysis
#3
Gretchen M Bruce, Lisa M Corey, Elizabeth N Pearce, Lewis E Braverman, Richard C Pleus
OBJECTIVE: To conduct a more robust examination of perchlorate exposure on iodide uptake inhibition (IUI) using pooled data from four clinical studies of perchlorate exposure. METHODS: To establish a response threshold for IUI, data were analyzed using segmented linear regression and benchmark dose (BMD) analysis. RESULTS: Segmented linear regression applied to data for 69 subjects representing nine doses identified a breakpoint corresponding to a change in the slope of the dose-response relationship of 3...
December 1, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29200013/computed-tomography-based-imaging-of-voxel-wise-lesion-water-uptake-in-ischemic-brain-relationship-between-density-and-direct-volumetry
#4
Gabriel Broocks, Fabian Flottmann, Marielle Ernst, Tobias Djamsched Faizy, Jens Minnerup, Susanne Siemonsen, Jens Fiehler, Andre Kemmling
OBJECTIVES: Net water uptake per volume of brain tissue may be calculated by computed tomography (CT) density, and this imaging biomarker has recently been investigated as a predictor of lesion age in acute stroke. However, the hypothesis that measurements of CT density may be used to quantify net water uptake per volume of infarct lesion has not been validated by direct volumetric measurements so far. The purpose of this study was to (1) develop a theoretical relationship between CT density reduction and net water uptake per volume of ischemic lesions and (2) confirm this relationship by quantitative in vitro and in vivo CT image analysis using direct volumetric measurements...
November 28, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29190950/therapeutic-response-and-long-term-outcome-of-differentiated-thyroid-cancer-with-pulmonary-metastases-treated-by-radioiodine-therapy
#5
Jing Yang, Meng Liang, Yingying Jia, Li Wang, Lin Lin, Jianhua Geng, Shengzu Chen, Ye-Xiong Li, Rong Zheng
Objective: To explore the therapeutic response (TR) and long-term outcomes of iodine-131 (I-131) treatment for patients with differentiated thyroid cancer and pulmonary metastases (DTC+PM), as well as the association between the assessment of TR and long-term outcomes. Methods: This retrospective study comprised 151 DTC+PM patients. TR was evaluated by changes in serum levels of thyroglobulin, anatomic imaging and iodine uptake in pulmonary nodules; logistic regression was applied to identify predictors...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29188596/observed-differentials-in-the-levels-of-selected-environmental-contaminants-among-mexican-and-other-hispanic-american-children-adolescents-adults-and-senior-citizens
#6
Ram B Jain
Starting with the 2007-2008 cycle, the National Health and Nutrition Examination Survey (NHANES) also oversampled Hispanics other than Mexicans (OHISP) making it possible to treat OHISP as a separate demographic group along with Mexican Americans (MAs), non-Hispanic whites (NHWs), and non-Hispanic blacks (NHBs). Yet, more often than not, OHISP have been merged with MA to form an all-Hispanic demographic group (HISP) thus limiting comparisons between NHW, NHB, and HISP. Consequently, for the first time, this study was undertaken to evaluate differences in the observed levels of selected environmental contaminants between MA and OHISP from five groups of environmental contaminants, namely, polycyclic aromatic hydrocarbons (PAHs), iodine uptake inhibitors (IUIs), environmental phenols (EPHs), priority pesticides (PPs), and perfluoroalkyl acids (PFAAs)...
November 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29185082/multi-energy-spectral-ct-adding-value-in-emergency-body-imaging
#7
Gopal V Punjabi
Most vendors offer scanners capable of dual- or multi-energy computed tomography (CT) imaging. Advantages of multi-energy CT scanning include superior tissue characterization, detection of subtle iodine uptake differences, and opportunities to reduce contrast dose. However, utilization of this technology in the emergency department (ED) remains low. The purpose of this pictorial essay is to illustrate the value of multi-energy CT scanning in emergency body imaging.
November 28, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29178592/a-3d-covalent-organic-framework-with-exceptionally-high-iodine-capture-capability
#8
Yanan Gao, Chang Wang, Yu Wang, Rile Ge, Xuedan Song, Xueqing Xing, Qike Jiang, Hui Lu, Ce Hao, Xinwen Guo, Donglin Jiang
Using porous materials to cope with environmental issues is promising but remains a challenge especially for removing the radioactive vapor wastes in fission because of harsh adsorption conditions. Here we report a new stable covalent organic framework (COF) as a porous platform for removing iodine vapor - a major radioactive fission waste. The three-dimensional COF consists of a diamond topology knotted by adamantane units, creates ordered one-dimensional pores and are highly porous. The COF enables the removal of iodine vapor via charge transfer complex formation with the pore walls to achieve exceptional capacity...
November 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29177256/errors-in-the-absorbed-and-the-administered-131i-therapeutic-dose-in-patients-with-graves-disease-a-suggested-more-precise-technique
#9
Yangchun Chen, Jincheng Huang, Yuehui Wang, Sipei Xie, Fang He
OBJECTIVE: The aim of this study was to evaluate the relative error (RE) in the thyroid absorbed dose (TD) of iodine-131 (131I) in patients with Graves' disease comparing the simplified Quimby-Marinelli-Hine formula method (sQMHF) and the Standard Operational Procedures for dosimetry (SOPD) recommended by the European Association of Nuclear Medicine. PATIENTS AND METHODS: This study included 45 patients with Graves' disease 12 men and 33 women; age 44.1±12.8 years...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29172135/potentiation-by-potassium-iodide-reveals-that-the-anionic-porphyrin-tpps4-is-a-surprisingly-effective-photosensitizer-for-antimicrobial-photodynamic-inactivation
#10
Liyi Huang, Ahmed El-Hussein, Weijun Xuan, Michael R Hamblin
We recently reported that addition of the non-toxic salt, potassium iodide can potentiate antimicrobial photodynamic inactivation of a broad-spectrum of microorganisms, producing many extra logs of killing. If the photosensitizer (PS) can bind to the microbial cells, then delivering light in the presence of KI produces short-lived reactive iodine species, while if the cells are added after light the killing is caused by molecular iodine produced as a result of singlet oxygen-mediated oxidation of iodide. In an attempt to show the importance of PS-bacterial binding, we compared two charged porphyrins, TPPS4 (thought to be anionic and not able to bind to Gram-negative bacteria) and TMPyP4 (considered cationic and well able to bind to bacteria)...
October 31, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29165912/reproducibility-of-radioactive-iodine-uptake-raiu-measurements
#11
Matthieu Pelletier-Galarneau, Patrick Martineau, Ran Klein, Matthew Henderson, Lionel S Zuckier
BACKGROUND: Measurement of radioactive iodine uptake (RAIU) is an important aspect of the assessment and treatment of patients with hyperthyroidism. Its uncertainty affects how much of a true change in RAIU can be detected as well as appropriateness of the therapy dosage upon which it is based. In this study, a method of estimating the reproducibility and least significant change (LSC) values for RAIU measurements, and the implications of the values observed are discussed, with emphasis on application to quality assurance initiatives...
November 22, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29158901/dosing-of-radioactive-iodine-in-end-stage-renal-disease-patient-with-thyroid-cancer
#12
Mallika Bhat, Matty Mozzor, Savneek Chugh, Vamsi Buddharaju, Monica Schwarcz, Guy Valiquette
We describe detailed administration of thyroidal and extrathyroidal doses of radioiodine to a patient with end-stage renal disease on hemodialysis. A thorough description of area under curve measurements in a patient with compromised renal function has rarely been described in the literature. Few publications have described thyroid cancer management of patients on hemodialysis, and we believe our management will aid in patient treatment in the future. Learning points: Scheduling of hemodialysis is important when administering radioactive iodine...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29140837/disruption-of-biofilms-and-neutralization-of-bacteria-using-hypochlorous-acid-solution-an-in-vivo-and-in-vitro-evaluation
#13
Anna Day, Abdulnaser Alkhalil, Bonnie C Carney, Hilary N Hoffman, Lauren T Moffatt, Jeffrey W Shupp
OBJECTIVES: The aims of this study were to assess the effectiveness of a hypochlorous acid-based wound cleanser (Vashe Wound Solution [VWS], SteadMed Medical, Fort Worth, Texas) in disrupting methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa biofilms relative to other cleansers using an in vitro collagen biofilm model and to evaluate cleansers' cytotoxicity. The bioburden reduction of venous stasis wounds by VWS and another cleanser was evaluated. METHODS: Plates coated with collagen films incubated with active bacteria cultures to yield biofilm mimics were treated with VWS, 1% and 10% povidone-iodine (PI), 0...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29127250/malignant-peripheral-nerve-sheath-tumours-of-the-pericardium-in-a-patient-with-neurofibromatosis-type-1-the-diagnostic-value-of-18f-fdg-pet-ct-and-i-123-mibg-spect-ct
#14
Mathieu Charest, Josephine Pressacco, Jaramie Thomas-Gittens
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29123883/delayed-autonomic-neuropathy-in-a-patient-with-diethylene-glycol-poisoning-a-case-report
#15
Hiroki Kamada, Hideaki Suzuki, Saori Yamamoto, Ryosuke Nomura, Shigeki Kushimoto
Case: A 72-year-old man presented to our hospital after ingesting insecticide containing approximately 2 mL/kg diethylene glycol, which exceeded the lethal dose of 1 mL/kg. The patient recovered from critical symptoms on acute phase until day 3, but received artificial ventilation for muscle weakness secondary to sensorimotor neuropathy on days 11-54. Outcome: Even after marked improvement from sensorimotor neuropathy, the patient continued to complain of orthostatic hypotension...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29113356/prediction-of-thyroidal-131-i-effective-half-life-in-patients-with-graves-disease
#16
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Jian Tan, Yajing He, Zhaowei Meng
Purpose: Calculation of effective thyroidal half-life (Teff) of iodine-131((131)I) is cumbersome and tedious. The aim of this study was to investigate factors that could be used to predict Teff and to develop a Teff prediction model in Graves' disease patients. Methods: A total of 256 patients with GD were involved in this study. We investigated the influences of age, gender, disease duration, thyroid weight, antithyroid drugs, antithyroid drugs discontinuation period (ADP), thyroid function indexes, thyroid autoantibodies, thyroid-stimulating hormone receptor antibody (TRAb) level and radioactive iodine uptake (RAIU) values before (131)I therapy on Teff, applying univariate and multivariate analyses...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112772/regulation-of-thyroid-sodium-iodide-symporter-in-different-stages-of-goiter-possible-involvement-of-ros
#17
L P L Matos, R Cortez-Cardoso, L C Cardoso-Weide, M L Freitas, D L S G Silva, A C F Ferreira
Na(+) /I(-) symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5 and 21 days, to achieve different status of goiter. We then evaluated the effect of MMI removal for 1 day (R1d), after 5 (R1d-5d) or 21 (R1d-21d) days of MMI treatment. MMI increased thyroid weight, iodide uptake and in vitro TPO activity in a time-dependent way...
November 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29110129/real-life-management-and-outcome-of-thyroid-carcinoma-related-bone-metastases-results-from-a-nationwide-multicenter-experience
#18
G Mazziotti, A M Formenti, M B Panarotto, E Arvat, A Chiti, A Cuocolo, M E Dottorini, C Durante, L Agate, S Filetti, F Felicetti, A Filice, L Pace, T Pellegrino, M Rodari, M Salvatori, C Tranfaglia, A Versari, D Viola, S Frara, A Berruti, A Giustina, R Giubbini
PURPOSE AND PATIENTS: The M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11-87) with differentiated thyroid carcinoma (DTC). RESULTS: Radio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47...
November 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29102640/radioactive-iodine-capture-and-storage-from-water-using-magnetite-nanoparticles-encapsulated-in-polypyrrole
#19
Dilip K L Harijan, Vimlesh Chandra, Taeseung Yoon, Kwang S Kim
The effective capture and storage of radioactive iodine is of importance for nuclear waste storage during nuclear power station accidents. Here we report Fe3O4@PPy powder containing ∼12nm magnetite (Fe3O4) nanoparticles encapsulated in the polypyrrole (PPy) matrix. It shows 1627mg/g uptake of iodine dissolved in water, within 2h at room temperature. Fe3O4@PPy is ferromagnetic in nature and can be separated from water using external magnetic field. The nitrogen gas sweeping test at 30°C shows release of 2% iodine from iodine adsorbed Fe3O4@PPy, revealing stable storage of iodine for a moderate period...
November 2, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29101822/internal-dosimetry-of-inhaled-iodine-131
#20
Mitra Kiani Nasab, Laleh Rafat Motavalli, Hashem Miri Hakimabad
In this paper, the dose assessment for the iodine inhalation exposure in 19 aerosol sizes and three gas/vapor forms at three levels of thyroid uptake, was performed. Two different modes of work (light vs. heavy) and breathing (nose vs. mouth) for aerosol inhalation were investigated. In order to calculate the cumulated activities per unit of inhaled activity, a combined model which included the latest models of both human respiratory and alimentary tract was developed. The S values for (131)I were computed based on the ICRP adult male and female reference voxel phantoms by the Monte Carlo method...
November 1, 2017: Journal of Environmental Radioactivity
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