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https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#1
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28811561/analysis-of-risk-factors-of-rapid-thyroidal-radioiodine-131-turnover-in-graves-disease-patients
#2
Ruiguo Zhang, Jian Tan, Renfei Wang, Guizhi Zhang, Qiang Jia, Zhaowei Meng, Yueqian Zhang
Rapid iodine-131((131)I) turnover in the thyroid gland is an important feature of Graves' disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid (131)I turnover. The clinical data on 2543 patients were retrospectively reviewed. Patients were divided into 2 groups depending on present or absent with rapid (131)I turnover defined as a 4-hour to 24-hour (131)I uptake ratio of ≥1. Overall, 590 cases (23.2%) had a rapid (131)I turnover...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806348/radioprotective-effect-of-vitamin-e-on-salivary-glands-after-radioiodine-therapy-for-differentiated-thyroid-cancer-a-randomized-controlled-trial
#3
Arun Upadhyaya, Pingping Zhou, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan, Xiaoran Wang, Xuemeng Zhang, Wan Zhang
OBJECTIVES: This study aimed to examine the radioprotective effect of vitamin E on salivary glands after radioactive iodine (I) therapy in patients with differentiated thyroid cancer. PATIENTS AND METHODS: Eighty-two patients with differentiated thyroid cancer were enrolled in this study. They were divided randomly into four groups (control group: 22 cases, group A: 23 cases, group B: 22 cases, and group C: 15 cases) before postsurgical ablation therapy with 100 mCi I...
August 11, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28800880/radioactive-iodine-131-i-uptake-in-an-ovarian-teratoma
#4
M Oporto, N Orta, F Cepa, M Pons, M Cabrer, C Peña
No abstract text is available yet for this article.
August 8, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28749399/re-establishment-of-normal-radioactive-iodine-uptake-reference-range-in-the-era-of-universal-salt-iodization-in-the-indian-population
#5
Sanjana Ballal, Ramya Soundararajan, Chandrasekhar Bal
BACKGROUND & OBJECTIVES: The reference radioactive iodine uptake (RAIU) values established in the 1970s in the era of widespread iodine deficiency were relatively high. Now, after four decades of successful Universal Salt Iodization (USI) programme in India, there is a need to re-establish these reference ranges. The present study was aimed to quantify the two-hour and 24-h RAIU values in iodine sufficient euthyroid individuals and validate the results in Graves' and Hashimoto's thyroiditis patients...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28724406/iodine-concentration-calculated-by-dual-energy-computed-tomography-dect-as-a-functional-parameter-to-evaluate-thyroid-metabolism-in-patients-with-hyperthyroidism
#6
Duong Duc Binh, Takahito Nakajima, Hidenori Otake, Tetsuya Higuchi, Yoshito Tsushima
BACKGROUND: Thyroid function in patients with Grave's disease is usually evaluated by thyroid scintigraphy with radioactive iodine. Recently, dual-energy computed tomography (DECT) with two different energy X-rays can calculate iodine concentrations and can be applied for iodine measurements in thyroid glands. This study aimed to assess the potential use of DECT for the functional assessment of the thyroid gland. METHODS: Thirteen patients with Grave's disease treated at our hospital from May to September 2015 were included in this retrospective study...
July 19, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28710576/the-effect-of-iodine-uptake-on-radiation-dose-absorbed-by-patient-tissues-in-contrast-enhanced-ct-imaging-implications-for-ct-dosimetry
#7
Kostas Perisinakis, Antonis Tzedakis, Kostas Spanakis, Antonios E Papadakis, Adam Hatzidakis, John Damilakis
OBJECTIVES: To investigate the effect of iodine uptake on tissue/organ absorbed doses from CT exposure and its implications in CT dosimetry. METHODS: The contrast-induced CT number increase of several radiosensitive tissues was retrospectively determined in 120 CT examinations involving both non-enhanced and contrast-enhanced CT imaging. CT images of a phantom containing aqueous solutions of varying iodine concentration were obtained. Plots of the CT number increase against iodine concentration were produced...
July 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28705916/biodistribution-and-dosimetry-of-18-f-meta-fluorobenzyl-guanidine-mfbg-a-first-in-human-pet-ct-imaging-study-of-patients-with-neuroendocrine-malignancies
#8
Neeta Pandit-Taskar, Pat B Zanzonico, Kevin D Staton, Jorge A Carrasquillo, Diane Reidy-Lagunes, Serge K Lyashchenko, Eva Burnazi, Hanwen Zhang, Jason S Lewis, Ronald Blasberg, Steven M Larson, Wolfgang Andreas Weber, Shakeel Modak
Introduction: Iodine-123-meta-iodobenzylguanidine ((123)I-MIBG) imaging is currently a mainstay in the evaluation of many neuroendocrine tumors, especially neuroblastoma. (123)I-MIBG imaging has several limitations that can be overcome by the use of a PET agent. (18)F-MFBG is a positron emission tomography (PET) analog of MIBG that may allow for single-day, high-resolution quantitative imaging. We conducted a first-in-human study of (18)F-MFBG PET imaging to evaluate the safety, feasibility, pharmacokinetics, and dosimetry of (18)F-MFBG in neuroendocrine tumors (NETs)...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28700488/correlation-of-iodine-uptake-and-perfusion-parameters-between-dual-energy-ct-imaging-and-first-pass-dual-input-perfusion-ct-in-lung-cancer
#9
COMPARATIVE STUDY
Xiaoliang Chen, Yanyan Xu, Jianghui Duan, Chuandong Li, Hongliang Sun, Wu Wang
To investigate the potential relationship between perfusion parameters from first-pass dual-input perfusion computed tomography (DI-PCT) and iodine uptake levels estimated from dual-energy CT (DE-CT).The pre-experimental part of this study included a dynamic DE-CT protocol in 15 patients to evaluate peak arterial enhancement of lung cancer based on time-attenuation curves, and the scan time of DE-CT was determined. In the prospective part of the study, 28 lung cancer patients underwent whole-volume perfusion CT and single-source DE-CT using 320-row CT...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28688242/abnormal-renal-parenchyma-accumulation-of-123-i-mibg-in-a-child-with-renal-artery-stenosis
#10
Randy Yeh, Ahmed Mohammed, Aleksandr Margolin, Peter Schlossberg, Rama S Ayyala
Hypertension is rare in the pediatric population, however renal artery stenosis (RAS) is an important cause that can be difficult to diagnose. Doppler ultrasound is the first line imaging modality, with computed tomography and magnetic resonance imaging as adjunct modalities, all with variable sensitivity for RAS. The gold standard for evaluation of RAS is invasive selective catheter angiography. We present a unique multimodality case of abnormal radiotracer uptake in the renal parenchyma on 123-Iodine metaiodobenzylguanidine ((123)I MIBG) scan in a patient with unilateral RAS...
July 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28670511/radioactive-iodine-therapy-and-glucose-tolerance
#11
REVIEW
Roghaieh Samadi, Babak Shafiei, Fereidoun Azizi, Asghar Ghasemi
Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28662033/a-phase-i-study-of-pazopanib-in-combination-with-escalating-doses-of-131i-in-patients-with-well-differentiated-thyroid-carcinoma-borderline-refractory-to-radioiodine
#12
Laura Q Chow, Rafael Santana-Davila, Austin Pantel, Mara Roth, Leslie N Anderson, Alan Failor, Robert Doot, David Mankoff
OBJECTIVE: This trial was conducted to evaluate the ability of pazopanib to overcome therapeutic 131I resistance. MATERIALS, METHODS AND PATIENTS: This phase 1 trial assesses the combination of pazopanib and escalating doses of radioiodine (131I) in patients with recurrent or metastatic thyroid cancer that are borderline or relatively iodine refractory. Radioiodine uptake scans were assessed post therapy and compared to historical pre-treatment scans. Patients underwent FDG PET/CT before and after the initial pazopanib treatment to identify the impact of pazopanib on the cancer prior to 131I therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28660918/iodine-131-labeled-transferrin-capped-polypyrrole-nanoparticles-for-tumor-targeted-synergistic-photothermal-radioisotope-therapy
#13
Xuejiao Song, Chao Liang, Liangzhu Feng, Kai Yang, Zhuang Liu
Combining different therapeutic functions within single tumor-targeted nanoscale delivery systems is promising to overcome the limitations of conventional cancer therapies. Herein, transferrin that recognizes transferrin receptors up-regulated on tumor cells is pre-labeled with iodine-131 ((131)I) and then utilized as the stabilizer in the fabrication of polypyrrole (PPy) nanoparticles. The obtained transferrin-capped PPy@Tf-(131)I nanoparticles could be used for tumor-targeted radioisotope therapy (RIT) and photothermal therapy (PTT), by employing beta-emission from (131)I and the intrinsic high near-infrared (NIR) absorbance of PPy, respectively...
June 29, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28659595/cellular-uptake-of-prommp-2-timp-2-complexes-by-the-endocytic-receptor-megalin-lrp-2
#14
Manuel Johanns, Pascale Lemoine, Virginie Janssens, Giuseppina Grieco, Soren K Moestrup, Rikke Nielsen, Erik I Christensen, Pierre J Courtoy, Hervé Emonard, Etienne Marbaix, Patrick Henriet
Matrix metalloproteinases (MMPs) are regulated at multiple transcriptional and post-transcriptional levels, among which receptor-mediated endocytic clearance. We previously showed that low-density lipoprotein receptor-related protein-1 (LRP-1) mediates the clearance of a complex between the zymogen form of MMP-2 (proMMP-2) and tissue inhibitor of metalloproteinases, TIMP-2, in HT1080 human fibrosarcoma cells. Here we show that, in BN16 rat yolk sac cells, proMMP-2:TIMP-2 complex is endocytosed through a distinct LRP member, megalin/LRP-2...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28658505/fast-kvp-switching-dual-energy-contrast-enhanced-thorax-and-cardiac-ct-a-phantom-study-on-the-accuracy-of-iodine-concentration-and-effective-atomic-number-measurement
#15
Antonios E Papadakis, John Damilakis
PURPOSE: To assess the effect of vessel diameter and exposure parameters on the estimation accuracy of concentration and effective atomic number (Zeff ) of iodine (I) in contrast-enhanced thorax and cardiac dual-energy CT using a modern fast kVp-switching CT scanner. METHODS: A standard semi-anthropomorphic cardiac CT phantom devised to simulate the human chest at three different body habitus i.e. medium-sized, large-sized, and obese, was scanned using a fast kVp-switching Revolution-GSI GE CT scanner...
June 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28640094/effects-of-first-radioiodine-ablation-on-functions-of-salivary-glands-in-patients-with-differentiated-thyroid-cancer
#16
Arun Upadhyaya, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Pingping Zhou, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan
The aim of this study was to evaluate the effects of the first radioactive iodine (I) therapy on functions of salivary glands in patients with differentiated thyroid carcinoma (DTC).There were 36 consented patients with DTC enrolled in this study, who received 3.7 GBq (100mCi) I for ablation after total thyroidectomy. Salivary gland function was assessed using salivary gland scintigraphy in two phases, one 4 hours before and the other 6 months after I therapy (both under thyrotropin stimulation condition)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28635633/new-insights-in-thyroid-cancer-and-p53-family-proteins
#17
REVIEW
Livia Manzella, Stefania Stella, Maria Stella Pennisi, Elena Tirrò, Michele Massimino, Chiara Romano, Adriana Puma, Martina Tavarelli, Paolo Vigneri
Thyroid cancers are common endocrine malignancies that comprise tumors with different clinical and histological features. Indeed, papillary and follicular thyroid cancers are slow-growing, well-differentiated tumors, whereas anaplastic thyroid cancers are undifferentiated neoplasias that behave much more aggressively. Well-differentiated thyroid carcinomas are efficiently cured by surgery and radioiodine, unlike undifferentiated tumors that fail to uptake radioactive iodine and are usually resistant to chemotherapy...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28626553/stepwise-crystallographic-visualization-of-dynamic-guest-binding-in-a-nanoporous-framework
#18
Gabriel Brunet, Damir A Safin, Mohammad Z Aghaji, Koen Robeyns, Ilia Korobkov, Tom K Woo, Muralee Murugesu
Binding sites are at the heart of all host-guest systems, whether biological or chemical. When considering binding sites that form covalent bonds with the guest, we generally envision a single, highly specific binding motif. Through single-crystal X-ray crystallography, the dynamic binding of a guest that displays a variety of covalent binding motifs in a single site of adsorption is directly observed for the first time. The stepwise crystallographic visualization of the incorporation of I2 within a porous MOF is presented, wherein the preferred binding motifs throughout the uptake process are identified...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28618195/novel-reductive-dehalogenases-from-the-marine-sponge-associated-bacterium-desulfoluna-spongiiphila
#19
Jie Liu, Nora Lopez, Young-Beom Ahn, Tatyana Goldberg, Yana Bromberg, Lee J Kerkhof, Max M Häggblom
Desulfoluna spongiiphila strain AA1 is an organohalide respiring bacterium, isolated from the marine sponge Aplysina aerophoba, that can use brominated and iodinated phenols, in addition to sulfate and thiosulfate as terminal electron acceptors. The genome of Desulfoluna spongiiphila strain AA1 is approximately 6.5 Mb. Three putative reductive dehalogenase (rdhA) genes involved in respiratory metabolism of organohalides were identified within the sequence. Conserved motifs found in respiratory reductive dehalogenases (a twin arginine translocation signal sequence and two iron-sulfur clusters) were present in all three putative AA1 rdhA genes...
June 15, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28616978/synthesis-and-preclinical-characterization-of-a-cationic-iodinated-imaging-contrast-agent-ca4-and-its-use-for-quantitative-computed-tomography-of-ex-vivo-human-hip-cartilage
#20
Rachel C Stewart, Amit N Patwa, Hrvoje Lusic, Jonathan D Freedman, Michel Wathier, Brian D Snyder, Ali Guermazi, Mark W Grinstaff
Contrast agents that go beyond qualitative visualization and enable quantitative assessments of functional tissue performance represent the next generation of clinically useful imaging tools. An optimized and efficient large-scale synthesis of a cationic iodinated contrast agent (CA4+) is described for imaging articular cartilage. Contrast-enhanced CT (CECT) using CA4+ reveals significantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic or nonionic agents, and CA4+ uptake follows Donnan equilibrium theory...
June 27, 2017: Journal of Medicinal Chemistry
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