Vincent Di Martino, Josselin Questiaux, Tristan Lemagoarou, Delphine Weil, Sophie Vendeville, Cornelius Engelmann, Jinhua Hu, Virendra Singh, Philip N Newsome, Sadhna B Lal, Shiv K Sarin, Thomas Berg, Thierry Thevenot
BACKGROUND: GCSF may improve the prognosis of severe liver disease by promoting liver regeneration and immune restoration. Our Aim was to investigate its controversial efficacy in decompensated cirrhosis, acute alcoholic hepatitis (AAH), or acute-on-chronic liver failure (ACLF) through meta-analysis. METHODS: Meta-analysis of proportions (random effect model) including 19 RCTs (1287 patients from 16 Asian and 3 European studies including 487 ACLF, 231 AAH and 569 cirrhotic patients) evaluating survival at day-28, day-90, 6 months, one year, and/or occurrence of sepsis as major outcomes...
November 2023: Clinics and Research in Hepatology and Gastroenterology