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Internal medicine pear

Stephanie M de Boer, Melanie E Powell, Linda Mileshkin, Dionyssios Katsaros, Paul Bessette, Christine Haie-Meder, Petronella B Ottevanger, Jonathan A Ledermann, Pearly Khaw, Alessandro Colombo, Anthony Fyles, Marie-Helene Baron, Henry C Kitchener, Hans W Nijman, Roy F Kruitwagen, Remi A Nout, Karen W Verhoeven-Adema, Vincent T Smit, Hein Putter, Carien L Creutzberg
BACKGROUND: About 15% of patients with endometrial cancer have high-risk features and are at increased risk of distant metastases and endometrial cancer-related death. We designed the PORTEC-3 trial to investigate the benefit of adjuvant chemoradiotherapy compared with radiotherapy alone for women with high-risk endometrial cancer. METHODS: PORTEC-3 was a multicentre, open-label, randomised, international trial. Women with high-risk endometrial cancer were randomly allocated (1:1) to radiotherapy alone (48·6 Gy) in 1·8 Gy fractions five times a week or chemoradiotherapy (two cycles concurrent cisplatin 50 mg/m(2) and four adjuvant cycles of carboplatin area under the curve [AUC] 5 and paclitaxel 175 mg/m(2)) using a biased coin minimisation procedure with stratification for participating centre, lymphadenectomy, stage of cancer, and histological type...
August 2016: Lancet Oncology
Marianne C Tondeur, Diego De Palma, Isabel Roca, Amy Piepsz, Hamphrey H Ham
OBJECTIVE: To evaluate the interobserver reproducibility in reporting on technetium-99m (99mTc) dimercaptosuccinic acid (DMSA) scan in children. METHODS: Sixty 99mTc-DMSA scans, issued from three centres, were distributed by e-mail to nuclear medicine physicians from the five continents interested in paediatric nuclear medicine. Observers had to choose, for each kidney, among four answers: normal, abnormal, equivocal or poor quality. An additional question was the location of the lesion if any: upper part, mid part, lower part...
April 2009: Nuclear Medicine Communications
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