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Chikungunya CHIKV

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https://www.readbyqxmd.com/read/28107342/seroprevalence-of-chikungunya-virus-in-a-rural-community-in-brazil
#1
Rivaldo V Cunha, Karen S Trinta, Camila A Montalbano, Michel V F Sucupira, Maricelia M de Lima, Erenilde Marques, Izilyanne H Romanholi, Julio Croda
BACKGROUND: The emergence of the Chikungunya virus (CHIKV) is currently expanding. In 2015, 38,332 cases of Chikungunya were reported to the Brazilian epidemiological surveillance system. Eighteen months after notification of the first case in the city of Feira de Santana, we conducted the first serosurvey to define the magnitude of transmission in a rural community in Brazil. METHODOLOGY/MAIN FINDINGS: The serosurvey was conducted in a random sample of 450 residences in the Chapada district, located 100 kilometers from Feira de Santana...
January 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28105853/identification-of-potential-molecular-associations-between-chikungunya-virus-non-structural-protein-2-and-human-host-proteins
#2
J Rana, S Gulati, S Rajasekharan, A Gupta, V Chaudhary, S Gupta
Chikungunya virus (CHIKV) non-structural protein 2 (nsP2) is considered to be the master regulator of viral RNA replication and host responses generated during viral infection. This protein has two main functional domains: an N-terminal domain which exhibits NTPase, RNA triphosphatase and helicase activities and a C-terminal protease domain. Understanding how CHIKV nsP2 interacts with its host proteins is essential for elucidating all the required processes for viral replication and pathogenesis along with the identification of potential targets for antiviral therapy...
January 19, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28100218/antiviral-effect-of-compounds-derived-from-the-seeds-of-mammea-americana-and-tabernaemontana-cymosa-on-dengue-and-chikungunya-virus-infections
#3
Cecilia Gómez-Calderón, Carol Mesa-Castro, Sara Robledo, Sergio Gómez, Santiago Bolivar-Avila, Fredyc Diaz-Castillo, Marlen Martínez-Gutierrez
BACKGROUND: The transmission of Dengue virus (DENV) and Chikungunya virus (CHIKV) has increased worldwide, due in part to the lack of a specific antiviral treatment. For this reason, the search for compounds with antiviral potential, either as licensed drugs or in natural products, is a research priority. The objective of this study was to identify some of the compounds that are present in Mammea americana (M. americana) and Tabernaemontana cymosa (T. cymosa) plants and, subsequently, to evaluate their cytotoxicity in VERO cells and their potential antiviral effects on DENV and CHIKV infections in those same cells...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28081143/engineered-aedes-aegypti-jak-stat-pathway-mediated-immunity-to-dengue-virus
#4
Natapong Jupatanakul, Shuzhen Sim, Yesseinia I Angleró-Rodríguez, Jayme Souza-Neto, Suchismita Das, Kristin E Poti, Shannan L Rossi, Nicholas Bergren, Nikos Vasilakis, George Dimopoulos
We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infection with several dengue virus (DENV) serotypes in the midgut as well as systemically and in the salivary glands. The impact of the transgenes Dome and Hop on mosquito longevity was minimal, but it resulted in a compromised fecundity when compared to wild-type mosquitoes...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28081120/epidemiology-of-chikungunya-virus-outbreaks-in-guadeloupe-and-martinique-2014-an-observational-study-in-volunteer-blood-donors
#5
Pierre Gallian, Isabelle Leparc-Goffart, Pascale Richard, Françoise Maire, Olivier Flusin, Rachid Djoudi, Jacques Chiaroni, Remi Charrel, Pierre Tiberghien, Xavier de Lamballerie
BACKGROUND: During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases. METHODS/PRINCIPAL FINDINGS: Individual testing for CHIKV RNA of all (n = 16,386) blood donations between Feb-24th 2014 and Jan-31st 2015 identified 0·36% and 0·42% of positives in Guadeloupe and Martinique, respectively...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28077641/chikungunya-influenza-nipah-and-semliki-forest-chimeric-viruses-with-vesicular-stomatitis-virus-actions-in-the-brain
#6
Anthony N van den Pol, Guochao Mao, Anasuya Chattopadhyay, John K Rose, John N Davis
: Recombinant vesicular stomatitis virus (VSV)-based chimeric viruses that include genes from other viruses show promise as vaccines and oncolytic viruses. However, the critical safety concern is the neurotropic nature conveyed by the VSV glycoprotein. VSVs that include the VSV glycoprotein gene, even in most recombinant attenuated strains, can still show substantial adverse or lethal actions in the brain. Here we test 4 chimeric viruses in the brain including those in which glycoprotein genes from Nipah, chikungunya, or influenza H5N1 viruses were substituted for the VSV glycoprotein gene...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28074128/epidemic-outbreak-of-chikungunya-in-two-neighboring-towns-in-the-colombian-caribbean-a-survival-analysis
#7
Misael Oviedo-Pastrana, Nelson Méndez, Salim Mattar, Germán Arrieta, Luty Gomezcaceres
BACKGROUND: The first autochthonous Chikungunya virus transmission in Colombia was reported in September 2014. Three months later, every town in the Caribbean region was affected, including the bordering towns of Ovejas and Corozal, in the department of Sucre. The objective of the study was to analyze and compare the temporal dynamics of the outbreak of Chikungunya in two towns of the department of Sucre. METHODS: Households with suspicious cases with clinical symptomatology for Chikungunya were enrolled...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28067803/regulation-of-viral-replication-apoptosis-and-pro-inflammatory-responses-by-17-aag-during-chikungunya-virus-infection-in-macrophages
#8
Tapas K Nayak, Prabhudutta Mamidi, Abhishek Kumar, Laishram Pradeep K Singh, Subhransu S Sahoo, Soma Chattopadhyay, Subhasis Chattopadhyay
Chikungunya virus (CHIKV) infection has re-emerged as a major public health concern due to its recent worldwide epidemics and lack of control measures. Although CHIKV is known to infect macrophages, regulation of CHIKV replication, apoptosis and immune responses towards macrophages are not well understood. Accordingly, the Raw264.7 cells, a mouse macrophage cell line, were infected with CHIKV and viral replication as well as new viral progeny release was assessed by flow cytometry and plaque assay, respectively...
January 6, 2017: Viruses
https://www.readbyqxmd.com/read/28063412/spectral-characterisation-antiviral-activities-in-silico-admet-and-molecular-docking-of-the-compounds-isolated-from-tectona-grandis-to-chikungunya-virus
#9
Sangeetha K, Indu Purushothaman, Rajarajan S
Chikungunya infection is treated symptomatically with antipyretics and anti-inflammatory drugs without any specific antiviral drug till date. The lack of an approved antiviral drug and the emergence of virulent strains after 2006 epidemics emphasize the need for the development of potential antiviral drugs to Chikungunya virus. Hence, we studied the antiviral activity of the extracts and compounds isolated from Tectona grandis leaves to both the Asian and East central South African strains of Chikungunya virus...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28039020/protein-kinases-c-as-potential-host-targets-for-the-inhibition-of-chikungunya-virus-replication
#10
Rana Abdelnabi, Siti Naqiah Amrun, Lisa F P Ng, Pieter Leyssen, Johan Neyts, Leen Delang
We have shown previously that prostratin, a non-tumor promoting phorbol ester, inhibits chikungunya virus (CHIKV)-induced cytopathic effects in vitro. Prostratin is a potent activator of protein kinases C (PKC), a family of related serine/threonine kinases that regulate many cellular processes such as proliferation and apoptosis. The objective of this study was to explore the mechanism of the anti-CHIKV activity of prostratin. Prostratin reduced the production of infectious virus particles and viral protein accumulation in a dose-dependent manner at a post-entry step during virus replication...
December 27, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28031347/impact-of-autocidal-gravid-ovitraps-on-chikungunya-virus-incidence-in-aedes-aegypti-diptera-culicidae-in-areas-with-and-without-traps
#11
Roberto Barrera, Veronica Acevedo, Gilberto E Felix, Ryan R Hemme, Jesus Vazquez, Jorge L Munoz, Manuel Amador
Puerto Rico detected the first confirmed case of chikungunya virus (CHIKV) in May 2014 and the virus rapidly spread throughout the island. The invasion of CHIKV allowed us to observe Aedes aegypti (L.) densities, infection rates, and impact of vector control in urban areas using CDC autocidal gravid ovitraps (AGO traps) for mosquito control over several years. Because local mosquitoes can only get the virus from infectious residents, detecting the presence of virus in mosquitoes functions as a proxy for the presence of virus in people...
December 28, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28030537/molecular-virologic-and-clinical-characteristics-of-a-chikungunya-fever-outbreak-in-la-romana-dominican-republic-2014
#12
Rose M Langsjoen, Rebecca J Rubinstein, Tiffany F Kautz, Albert J Auguste, Jesse H Erasmus, Liddy Kiaty-Figueroa, Renessa Gerhardt, David Lin, Kumar L Hari, Ravi Jain, Nicolas Ruiz, Antonio E Muruato, Jael Silfa, Franklin Bido, Matthew Dacso, Scott C Weaver
Since emerging in Saint Martin in 2013, chikungunya virus (CHIKV), an alphavirus transmitted by the Aedes aegypti mosquito, has infected approximately two million individuals in the Americas, with over 500,000 reported cases in the Dominican Republic (DR). CHIKV-infected patients typically present with a febrile syndrome including polyarthritis/polyarthralgia, and a macropapular rash, similar to those infected with dengue and Zika viruses, and malaria. Nevertheless, many Dominican cases are unconfirmed due to the unavailability and high cost of laboratory testing and the absence of specific treatment for CHIKV infection...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28001232/a-case-of-chikungunya-virus-disease-presenting-with-remarkable-acute-arthritis-of-a-previously-damaged-finger-joint
#13
Walter de Araujo Eyer-Silva, Henrique de Barros Pinto, Guilherme Almeida Rosa da Silva, Fernando Raphael de Almeida Ferry
Chikungunya virus (CHIKV) is a mosquito-borne arthritogenic alphavirus that has recently been introduced to Brazil. We report the case of a 36-year-old male patient from the City of Rio de Janeiro who developed molecularly-confirmed CHIKV disease and whose clinical picture was remarkable because of acute arthritis of an interphalangeal joint that had been damaged by trauma 8 years previously. This case illustrates that acute CHIKV disease may preferentially target previously damaged joints. Careful study of individual cases may provide valuable information on the presentation and management of this emerging zoonosis in Brazil...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27991917/a-chikungunya-fever-vaccine-utilizing-an-insect-specific-virus-platform
#14
Jesse H Erasmus, Albert J Auguste, Jason T Kaelber, Huanle Luo, Shannan L Rossi, Karla Fenton, Grace Leal, Dal Y Kim, Wah Chiu, Tian Wang, Ilya Frolov, Farooq Nasar, Scott C Weaver
Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inability of inactivated vaccines to replicate enhances safety at the expense of immunogenicity, often necessitating multiple doses and boosters. To overcome these tradeoffs, we developed the insect-specific alphavirus, Eilat virus (EILV), as a vaccine platform. To address the chikungunya fever (CHIKF) pandemic, we used an EILV cDNA clone to design a chimeric virus containing the chikungunya virus (CHIKV) structural proteins...
December 19, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27977670/serological-evidence-of-contrasted-exposure-to-arboviral-infections-between-islands-of-the-union-of-comoros-indian-ocean
#15
Koussay Dellagi, Nicolas Salez, Marianne Maquart, Sophie Larrieu, Amina Yssouf, Rahamatou Silaï, Isabelle Leparc-Goffart, Pablo Tortosa, Xavier de Lamballerie
A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27942016/dengue-and-chikungunya-virus-infections-among-young-febrile-adults-evaluated-for-acute-hiv-1-infection-in-coastal-kenya
#16
Carolyne N Ngoi, Matt A Price, Barry Fields, Juma Bonventure, Caroline Ochieng, Grace Mwashigadi, Amin S Hassan, Alexander N Thiong'o, Murugi Micheni, Peter Mugo, Susan Graham, Eduard J Sanders
BACKGROUND: Fever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya. METHODS: We tested plasma samples obtained in a cross-sectional study from febrile adult patients aged 18-35 years evaluated for AHI and malaria at urgent care seeking at seven health facilities in coastal Kenya in 2014-2015...
2016: PloS One
https://www.readbyqxmd.com/read/27920393/detection-of-wolbachia-in-aedes-albopictus-and-their-effects-on-chikungunya-virus
#17
Noor Afizah Ahmad, Indira Vythilingam, Yvonne A L Lim, Nur Zatil Aqmar A Zabari, Han Lim Lee
Wolbachia-based vector control strategies have been proposed as a means to augment the currently existing measures for controlling dengue and chikungunya vectors. Prior to utilizing Wolbachia as a novel vector control strategy, it is crucial to understand the Wolbachia-mosquito interactions. In this study, field surveys were conducted to screen for the infection status of Wolbachia in field-collected Aedes albopictus The effects of Wolbachia in its native host toward the replication and dissemination of chikungunya virus (CHIKV) was also studied...
December 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27920183/chikungunya-in-the-americas-recommendations-and-conclusions
#18
Barney S Graham, Patricia M Repik, Sergio Yactayo
Discovered in 1953, chikungunya virus (CHIKV) circulated in Africa and Southeast Asia, with periodic outbreaks, for many years. Highly efficient transmission following a genetic mutation of the virus in 2005 caused its global spread. Associated with significant morbidity, CHIKV creates a large public health burden, and despite various efforts, there are currently no licensed vaccines nor specific treatments. To garner a better understanding of the virus, identify gaps in knowledge, and guide the development of more-effective interventions, the World Health Organization and National Institute of Allergy and Infectious Diseases assembled global experts for discussion and review...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27920182/monoclonal-antibodies-as-prophylactic-and-therapeutic-agents-against-chikungunya-virus
#19
April M Clayton
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is responsible for considerable epidemics worldwide and recently emerged in the Americas in 2013. CHIKV may cause long-lasting arthralgia after acute infection. With currently no licensed vaccines or antivirals, the design of effective therapies to prevent or treat CHIKV infection is of utmost importance and will be facilitated by increased understanding of the dynamics of chikungunya. In this article, monoclonal antibodies against CHIKV as viable prophylactic and therapeutic agents will be discussed...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27920181/chikungunya-virus-vaccines-viral-vector-based-approaches
#20
Katrin Ramsauer, Frédéric Tangy
In 2013, a major chikungunya virus (CHIKV) epidemic reached the Americas. In the past 2 years, >1.7 million people have been infected. In light of the current epidemic, with millions of people in North and South America at risk, efforts to rapidly develop effective vaccines have increased. Here, we focus on CHIKV vaccines that use viral-vector technologies. This group of vaccine candidates shares an ability to potently induce humoral and cellular immune responses by use of highly attenuated and safe vaccine backbones...
December 15, 2016: Journal of Infectious Diseases
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