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Chikungunya CHIKV

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https://www.readbyqxmd.com/read/29789369/-wolbachia-w-stri-blocks-zika-virus-growth-at-two-independent-stages-of-viral-replication
#1
M J Schultz, A L Tan, C N Gray, S Isern, S F Michael, H M Frydman, J H Connor
Mosquito-transmitted viruses are spread globally and present a great risk to human health. Among the many approaches investigated to limit the diseases caused by these viruses are attempts to make mosquitos resistant to virus infection. Coinfection of mosquitos with the bacterium Wolbachia pipientis from supergroup A is a recent strategy employed to reduce the capacity for major vectors in the Aedes mosquito genus to transmit viruses, including dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus (ZIKV)...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29785069/genetic-characterization-of-chikungunya-virus-2009-isolates-from-south-india
#2
Gopalsamy Sarangan, Seema A Nayar, Monika Mani, Sudharsana Sundarrajan, Sathish Sankar, Gunasekaran Palani, Gracy Fathima Selvaraj, Jayachandran Damodharan, Karuppaiah Muthumani, Padma Srikanth
Chikungunya Virus (CHIKV) is a single stranded positive sense enveloped RNA virus. Re-emergence of CHIKV caused a massive outbreak with severe clinical manifestation affecting multiple organs. The genetic diversity of CHIKV, which caused recurring outbreaks in India, was studied. Blood samples were collected from suspected human cases of CHIKV infection in Chennai, Tamil Nadu and three Northern districts of Kerala in Southern India during the CHIKV outbreak in 2009. A partial E2 gene segment was amplified by RT-PCR...
2018: Bioinformation
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#3
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29774861/use-of-bead-based-serologic-assay-to-evaluate-chikungunya-virus-epidemic-haiti
#4
Eric W Rogier, Delynn M Moss, Kimberly E Mace, Michelle Chang, Samuel E Jean, Stevan M Bullard, Patrick J Lammie, Jean Frantz Lemoine, Venkatachalam Udhayakumar
The index case of chikungunya virus (CHIKV) in Haiti was reported during early 2014; the vector, the pervasive Aedes aegypti mosquito, promoted rapid spread throughout the country. During December 2014-February 2015, we collected blood samples from 4,438 persons at 154 sites (62 urban, 92 rural) throughout Haiti and measured CHIKV IgG by using a multiplex bead assay. Overall CHIKV seroprevalence was 57.9%; differences between rural (mean 44.9%) and urban (mean 78.4%) areas were pronounced. Logistic modeling identified the urban environment as a strong predictor of CHIKV exposure (adjusted odds ratio 3...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29772762/paradoxical-effect-of-chloroquine-treatment-in-enhancing-chikungunya-virus-infection
#5
Pierre Roques, Simon-Djamel Thiberville, Laurence Dupuis-Maguiraga, Fok-Moon Lum, Karine Labadie, Frédéric Martinon, Gabriel Gras, Pierre Lebon, Lisa F P Ng, Xavier de Lamballerie, Roger Le Grand
Since 2005, Chikungunya virus (CHIKV) re-emerged and caused numerous outbreaks in the world, and finally, was introduced into the Americas in 2013. The lack of CHIKV-specific therapies has led to the use of non-specific drugs. Chloroquine, which is commonly used to treat febrile illnesses in the tropics, has been shown to inhibit CHIKV replication in vitro. To assess the in vivo effect of chloroquine, two complementary studies were performed: (i) a prophylactic study in a non-human primate model (NHP); and (ii) a curative study "CuraChik", which was performed during the Reunion Island outbreak in 2006 in a human cohort...
May 17, 2018: Viruses
https://www.readbyqxmd.com/read/29772674/encapsidated-host-factors-in-alphavirus-particles-influence-midgut-infection-of-aedes-aegypti
#6
David Mackenzie-Liu, Kevin J Sokoloski, Sarah Purdy, Richard W Hardy
Transmission of mosquito-borne viruses requires the efficient infection of both a permissive vertebrate host and a competent mosquito vector. The infectivity of Sindbis virus (SINV), the type species of the Alphavirus genus, is influenced by both the original and new host cell. We have shown that infection of vertebrate cells by SINV, chikungunya virus (CHIKV), and Ross River virus (RRV) produces two subpopulations of virus particles separable based on density. In contrast, a single population of viral particles is produced by mosquito cells...
May 16, 2018: Viruses
https://www.readbyqxmd.com/read/29761765/arbovirus-surveillance-near-the-mexico-u-s-border-isolation-and-sequence-analysis-of-chikungunya-virus-from-patients-with-dengue-like-symptoms-in-reynosa-tamaulipas
#7
S Viridiana Laredo-Tiscareño, Carlos Machain-Williams, Mario A Rodríguez-Pérez, Javier A Garza-Hernandez, Gloria L Doria-Cobos, Rosa C Cetina-Trejo, Lucio A Bacab-Cab, Chandra S Tangudu, Jermilia Charles, Erick J De Luna-Santillana, Julian E Garcia-Rejon, Bradley J Blitvich
A total of 1,090 residents of the city of Reynosa, Tamaulipas, on the Mexico-U.S. border presented at hospitals and clinics of the Secretariat of Health, Mexico, in 2015 with symptoms characteristic of dengue. Dengue virus (DENV) antigen was detected by enzyme-linked immunosorbent assay in acute sera from 134 (12.3%) patients. Sera from select patients ( N = 34) were also tested for chikungunya virus (CHIKV) RNA by quantitative reverse transcription-polymerase chain reaction. Thirteen (38.2%) patients, including five DENV antigen-positive patients, were positive...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29759076/threats-of-zika-virus-transmission-for-asia-and-its-hindu-kush-himalayan-region
#8
Meghnath Dhimal, Sushma Dahal, Mandira Lamichhane Dhimal, Shiva Raj Mishra, Khem B Karki, Krishna Kumar Aryal, Ubydul Haque, Md Iqbal Kabir, Pradeep Guin, Azeem Mehmood Butt, Harapan Harapan, Qi-Yong Liu, Cordia Chu, Doreen Montag, David Alexander Groneberg, Basu Dev Pandey, Ulrich Kuch, Ruth Müller
Asia and its Hindu Kush Himalayan (HKH) region is particularly vulnerable to environmental change, especially climate and land use changes further influenced by rapid population growth, high level of poverty and unsustainable development. Asia has been a hotspot of dengue fever and chikungunya mainly due to its dense human population, unplanned urbanization and poverty. In an urban cycle, dengue virus (DENV) and chikungunya virus (CHIKV) are transmitted by Aedes aegypti and Ae. albopictus mosquitoes which are also competent vectors of Zika virus (ZIKV)...
May 15, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29751761/evaluation-of-an-immunochromatography-rapid-diagnosis-kit-for-detection-of-chikungunya-virus-antigen-in-india-a-dengue-endemic-country
#9
Jaspreet Jain, Tamaki Okabayashi, Navjot Kaur, Emi Nakayama, Tatsuo Shioda, Rajni Gaind, Takeshi Kurosu, Sujatha Sunil
BACKGROUND: Chikungunya virus (CHIKV) and dengue virus (DENV) are arboviruses that share the same Aedes mosquito vector, and there is much overlap in endemic areas. In India, co-infection with both viruses is often reported. Clinical manifestations of Chikungunya fever is often confused with dengue fever because clinical symptoms of both infections are similar. It is, therefore, difficult to differentiate from those of other febrile illnesses, especially dengue fever. We previously developed a CHIKV antigen detection immunochromatography (IC) rapid diagnosis kit [1]...
May 11, 2018: Virology Journal
https://www.readbyqxmd.com/read/29751486/current-strategies-for-inhibition-of-chikungunya-infection
#10
REVIEW
Bharat Bhusan Subudhi, Soma Chattopadhyay, Priyadarsee Mishra, Abhishek Kumar
Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with Dengue/Zika virus have highlighted the urgency for CHIKV management. Failure in developing effective vaccines or specific antivirals has fuelled further research. This review discusses updated strategies of CHIKV inhibition and provides possible future directions. In addition, it analyzes advances in CHIKV lifecycle, drug-target development, and potential hits obtained by in silico and experimental methods. Molecules identified with anti-CHIKV properties using traditional/rational drug design and their potential to succeed in subsequent stages of drug development have also been discussed...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29749366/experimental-zika-virus-infection-in-aedes-aegypti-susceptibility-transmission-co-infection-with-dengue-chikungunya-viruses
#11
Devendra T Mourya, Mangesh D Gokhale, Triparna D Majumdar, Pragya D Yadav, Vimal Kumar, Mangala S Mavale
Background & objectives: There are reports about the susceptibility of Aedes mosquitoes to ZIKV from various countries, however, no such information is available from Indian sub-continent, although, high level of group cross-reactivity of ZIKV with other flaviviruses has been reported. During outbreak situations, many cases of Dengue (DEN) and Chikungunya (CHIK) are reported. In such scenario, vector mosquitoes are likely to get co-infection/secondary-infection with one or other virus...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29747994/a-systematic-review-of-viral-exposures-as-a-risk-for-rheumatoid-arthritis
#12
F M Kudaeva, M R Speechley, J E Pope
OBJECTIVE: Different viral exposures have been implicated in the etiology of rheumatoid arthritis (RA). Evidence relating to the association between putative viral exposures and the development of RA was reviewed. METHODS: A systematic literature search was conducted using MEDLINE-OVID, EMBASE-OVID, PUBMED and Cochrane library databases. Articles were included if they were case-controls, cross-sectional or cohort studies and were published in English. Case-series were included if there was a lack of other study designs...
March 21, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29747416/molecular-and-clinical-characterization-of-chikungunya-virus-infections-in-southeast-mexico
#13
Kame A Galán-Huerta, Erik Martínez-Landeros, Juan L Delgado-Gallegos, Sandra Caballero-Sosa, Iliana R Malo-García, Ildefonso Fernández-Salas, Javier Ramos-Jiménez, Ana M Rivas-Estilla
Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information. The aim of this study was to perform a full description of the clinical features in confirmed Chikungunya-infected patients and describe the molecular epidemiology of CHIKV. We evaluated febrile patients who sought medical assistance in Tapachula, Chiapas, Mexico, from June through July 2015...
May 9, 2018: Viruses
https://www.readbyqxmd.com/read/29746539/a-new-american-subgroup-of-african-lineage-chikungunya-virus-detected-in-and-isolated-from-mosquitoes-collected-in-haiti-2016
#14
Sarah Keller White, Carla Mavian, Marco Salemi, John Glenn Morris, Maha A Elbadry, Bernard A Okech, John A Lednicky, James C Dunford
As part of on-going arboviral surveillance activity in a semi-rural region in Haiti, Chikungunya virus (CHIKV)-positive mosquito pools were identified in 2014 (the peak of the Caribbean Asian-clade epidemic), and again in 2016 by RT-PCR. In 2014, CHIKV was only identified in Aedes aegypti (11 positive pools/124 screened). In contrast, in sampling in 2016, CHIKV was not identified in Ae. aegypti, but, rather, in (a) a female Aedes albopictus pool, and (b) a female Culex quinquefasciatus pool. Genomic sequence analyses indicated that the CHIKV viruses in the 2016 mosquito pools were from the East-Central-South African (ECSA) lineage, rather than the Asian lineage...
2018: PloS One
https://www.readbyqxmd.com/read/29744032/miltefosine-inhibits-chikungunya-virus-replication-in-human-primary-dermal-fibroblasts
#15
Anuj Sharma, Manish Bhomia, Tze-Jou Yeh, Jay Singh, Radha K Maheshwari
Background : Chikungunya virus (CHIKV) is a re-emerging pathogen that has caused widespread outbreaks affecting millions of people around the globe. Currently, there is no specific therapeutic drug against CHIKV, with symptomatic treatment only to manage the disease. Pi3-akt signaling has been implicated in infection of several viruses including that of CHIKV. Effect of Pi3-akt signaling inhibitors on CHIKV replication was evaluated in this study. Methods : Human primary dermal fibroblast cells were treated with inhibitors of the Pi3-akt signaling pathway...
2018: F1000Research
https://www.readbyqxmd.com/read/29738826/co-infection-with-zika-and-chikungunya-viruses-associated-with-fetal-death
#16
Arnaldo Prata-Barbosa, Thaís Lira Cleto-Yamane, Jaqueline Rodrigues Robaina, Andrea Bittencourt Guastavino, Maria Clara de Magalhães-Barbosa, Rodrigo de Moraes Brindeiro, Roberto Andrade Medronho, Antonio José Ledo Alves da Cunha
We describe a case of fetal death associated with a recent infection by Chikungunya virus (CHIKV) in a Brazilian pregnant woman (positive RT-PCR in blood and placenta). Zika virus (ZIKV) infection during pregnancy was also identified, based on a positive RT-PCR in a fetal kidney specimen. The maternal infection caused by the ZIKV was asymptomatic and the CHIKV infection had a classical clinical presentation. The fetus had no apparent anomalies, but her weight was between the 3rd and 10th percentile for the gestational age...
May 5, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29737236/the-new-european-invader-aedes-finlaya-koreicus-a-potential-vector-of-chikungunya-virus
#17
Silvia Ciocchetta, Natalie A Prow, Jonathan M Darbro, Francesca D Frentiu, Sandro Savino, Fabrizio Montarsi, Gioia Capelli, John G Aaskov, Gregor J Devine
Arthropod-borne disease outbreaks, facilitated by the introduction of exotic mosquitoes, pose a significant public health threat. Recent chikungunya virus (CHIKV) epidemics in Europe highlight the importance of understanding the vector potential of invading mosquitoes. In this paper we explore the potential of Aedes koreicus, a mosquito new to Europe, to transmit CHIKV. Mosquitoes were challenged with CHIKV and maintained at two temperatures: 23 °C and a fluctuating temperature. Total CHIKV infection rates at 3, 10 and 14 days post-feeding were low for both temperature treatments (13...
May 8, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29733254/antibodies-against-chikungunya-in-northern-mozambique-during-dengue-outbreak-2014
#18
Argentina Muianga, Gabriela Pinto, Marilia Massangaie, Sadia Ali, John Oludele, Almiro Tivane, Kerstin I Falk, Nina Lagerqvist, Eduardo S Gudo
An outbreak of dengue and high densities of Aedes aegypti were reported in 2014 in northern Mozambique, suggesting an increased risk for other arboviruses such as chikungunya virus (CHIKV) in this region. The aim of this study was to investigate the occurrence of CHIKV during an outbreak of dengue virus (DENV) in Pemba city in northern Mozambique in 2014. Febrile patients (n = 146) seeking medical attention at the Pemba Provincial Hospital between March and April 2014 were enrolled in this study. Blood samples from each participant were tested for chikungunya and DENV RNA, IgM and IgG antibodies using PCR and ELISA, respectively...
May 7, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29730006/crystal-structure-of-chikungunya-virus-nsp2-cysteine-protease-reveals-a-putative-flexible-loop-blocking-its-active-site
#19
Manju Narwal, Harvijay Singh, Shivendra Pratap, Anjali Malik, Richard J Kuhn, Pravindra Kumar, Shailly Tomar
Chikungunya virus (CHIKV), a mosquito-borne pathogenic alphavirus is a growing public health threat. No vaccines or antiviral drug is currently available in the market for chikungunya treatment. nsP2pro, the viral cysteine protease, carries out an essential function of nonstructural polyprotein processing and forms four nonstructural proteins (nsPs) that makes the replication complex, hence constitute a promising drug target. In this study, crystal structure of nsP2pro has been determined at 2.59 Ǻ, which reveals that the protein consists of two subdomains: N-terminal protease subdomain and C-terminal methyltransferase subdomain...
May 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29709007/chikungunya-virus-infection-in-aruba-diagnosis-clinical-features-and-predictors-of-post-chikungunya-chronic-polyarthralgia
#20
Ralph Huits, Jaclyn De Kort, Riemsdijk Van Den Berg, Luis Chong, Achilleas Tsoumanis, Kaat Eggermont, Koen Bartholomeeusen, Kevin K Ariën, Jan Jacobs, Marjan Van Esbroeck, Emmanuel Bottieau, Lieselotte Cnops
BACKGROUND: Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of serologic and molecular assays to its diagnosis. In a cohort of confirmed CHIKV cases, we analysed the frequency, duration and predictors of post-chikungunya chronic polyarthralgia (pCHIK-CPA), defined as joint pains lasting longer than 6 weeks or longer than 1 year. METHODOLOGY: Patient sera obtained within 10 days of symptom onset were tested for CHIKV, using an indirect immunofluorescence test for the detection of CHIKV-specific Immunoglobulin M (IgM) and post-hoc, by reverse-transcription polymerase chain reaction (RT-PCR)...
2018: PloS One
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