keyword
MENU ▼
Read by QxMD icon Read
search

melanogenesis

keyword
https://www.readbyqxmd.com/read/28098220/comparative-transcriptome-analysis-of-raccoon-dog-skin-to-determine-melanin-content-in-hair-and-melanin-distribution-in-skin
#1
Zhanyu Du, Kai Huang, Jiaping Zhao, Xingchao Song, Xiumei Xing, Qiong Wu, Linbo Zhang, Chao Xu
The raccoon dog (Nyctereutes procyonoides) is an important canid fur-bearing animal species worldwide. Chinese raccoon dogs that present a white mutation, especially those with a white coat. Exploring melanin biosynthesis in the hair and skin of raccoon dogs is important for understanding the survival and evolutionary mechanisms of them. In this study, we measured the content of melanin in the hair of two types of raccoon dog and generated stained slices of skin tissue. The results indicated that melanin biosynthesis occurs in the wild-type (W) and white-type (B) raccoon dog skin, although less melanin is produced in B skin...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097901/skin-whitening-agents-medicinal-chemistry-perspective-of-tyrosinase-inhibitors
#2
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 played a major role in melanin synthesis. Specifically, tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin synthesis, and the downregulation of tyrosinase is the most prominent approach for the development of melanogenesis inhibitors...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28095579/development-and-clinical-assessment-of-a-comprehensive-product-for-pigmentation-control-in-multiple-ethnic-populations
#3
Elizabeth T Makino, Kuniko Kadoya, Monya L Sigler, Peter D Hino, Rahul C Mehta
BACKGROUND: Pigmentary changes in people of different ethnic origins are controlled by slight variations in key biological pathways leading to different outcomes from the same treatment. It is important to develop and test products for desired outcomes in varying ethnic populations. OBJECTIVES: To develop a comprehensive product (LYT2) that affects all major biological pathways controlling pigmentation and test for clinical efficacy and safety in different ethnic populations...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28051915/alisol-b-a-triterpene-from-alismatis-rhizoma-dried-rhizome-of-alisma-orientale-inhibits-melanin-production-in-murine-b16-melanoma-cells
#4
Ichiro Yoshida, Chihiro Ito, Shinya Matsuda, Akihiko Tsuji, Noriyuki Yanaka, Keizo Yuasa
To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis...
January 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28033525/dietary-polychlorinated-biphenyls-long-chain-n-3-polyunsaturated-fatty-acids-and-incidence-of-malignant-melanoma
#5
Carolina Donat-Vargas, Marika Berglund, Anders Glynn, Alicja Wolk, Agneta Åkesson
BACKGROUND: For malignant melanoma, other risk factors aside from sun exposure have been hardly explored. Polychlorinated biphenyls (PCBs)-mainly from fatty fish- may affect melanogenesis and promote melanoma progression, while long-chain n-3 polyunsaturated fatty acids seem to exert antineoplastic actions in melanoma cells. OBJECTIVES: We aimed to assess the association of validated estimates of dietary PCB exposure as well as the intake of eicosapentaenoic acid and docosahexaenoic acid (EPA-DHA), accounting for sun habits and skin type, with the risk of malignant melanoma in middle-aged and elderly women...
December 26, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28029168/trends-in-regenerative-medicine-repigmentation-in-vitiligo-through-melanocyte-stem-cell-mobilization
#6
REVIEW
Stanca A Birlea, Gertrude-E Costin, Dennis R Roop, David A Norris
Vitiligo is the most frequent human pigmentary disorder, characterized by progressive autoimmune destruction of mature epidermal melanocytes. Of the current treatments offering partial and temporary relief, ultraviolet (UV) light is the most effective, coordinating an intricate network of keratinocyte and melanocyte factors that control numerous cellular and molecular signaling pathways. This UV-activated process is a classic example of regenerative medicine, inducing functional melanocyte stem cell populations in the hair follicle to divide, migrate, and differentiate into mature melanocytes that regenerate the epidermis through a complex process involving melanocytes and other cell lineages in the skin...
December 28, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28026947/biodegradable-kojic-acid-based-polymers-controlled-delivery-of-bioactives-for-melanogenesis-inhibition
#7
Jonathan J Faig, Alysha Moretti, Laurie B Joseph, Yingyue Zhang, Mary Joy Nova, Kervin Smith, Kathryn E Uhrich
Kojic acid (KA) is a naturally occurring fungal metabolite that is utilized as a skin-lightener and anti-browning agent owing to its potent tyrosinase inhibition activity. While efficacious, KA's inclination to undergo pH-mediated, thermal-, and photo-degradation reduces its efficacy, necessitating stabilizing vehicles. To minimize degradation, poly(carbonate-esters) and polyesters comprised of KA and natural diacids were prepared via solution polymerization methods. In vitro hydrolytic degradation analyses revealed KA release was drastically influenced by polymer backbone composition (e...
December 27, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/28019642/recent-updates-on-melanocyte-biology-and-the-use-of-promising-bioactive-compounds-for-the-treatment-of-hypopigmentary-disorders-a-review
#8
Sharique A Ali, Ishrat Naaz, Kamal Uddin Zaidi, Ayesha Sharique Ali
Skin pigmentation is a broadly appearing phenomenon in nature which plays an important task of determining the appearance and biology of all vertebrates including human beings. Skin color is a crucial attribute, determined by the synthesis of melanin pigment within melanocytes by the process of melanogenesis and is regulated by many extrinsic as well as intrinsic factors. Tyrosinase catalyzes the key step of melanogenesis, dysfunction of tyrosinase leads to reduce melanin production which results in severe clinical and aesthetical problems of hypopigmentation...
December 23, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27988355/agmatine-modulates-melanogenesis-via-mitf-signaling-pathway
#9
Eun-Jeong Kwon, Moon-Moo Kim
Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition to the effect of agmatine on mushroom tyrosinase in vitro in the presence of different concentrations of agmatine...
December 13, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27941997/primary-cilia-negatively-regulate-melanogenesis-in-melanocytes-and-pigmentation-in-a-human-skin-model
#10
Hyunjung Choi, Ji Hyun Shin, Eun Sung Kim, So Jung Park, Il-Hong Bae, Yoon Kyung Jo, In Young Jeong, Hyoung-June Kim, Youngjin Lee, Hea Chul Park, Hong Bae Jeon, Ki Woo Kim, Tae Ryong Lee, Dong-Hyung Cho
The primary cilium is an organelle protruding from the cell body that senses external stimuli including chemical, mechanical, light, osmotic, fluid flow, and gravitational signals. Skin is always exposed to the external environment and responds to external stimuli. Therefore, it is possible that primary cilia have an important role in skin. Ciliogenesis was reported to be involved in developmental processes in skin, such as keratinocyte differentiation and hair formation. However, the relation between skin pigmentation and primary cilia is largely unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27941538/nf1-and-neurofibromin-emerging-players-in-the-genetic-landscape-of-desmoplastic-melanoma
#11
Meera Mahalingam
Neurofibromatosis type I (NF1), a monogenic disorder with an autosomal dominant mode of inheritance, is caused by alterations in the NF1 gene which codes for the protein neurofibromin. Functionally, NF1 is a tumor suppressor as it is GTPase-activating protein that negatively regulates the MAPK pathway. More recently, much attention has focused on the role of NF1 and neurofibromin in melanoma as mutations in NF1 have been found to constitute 1 of the 4 distinct genomic categories of melanoma, with the other 3 comprising BRAF, NRAS, and "triple-wild-type" subtypes...
January 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27924292/data-on-melanin-production-in-b16f1-melanoma-cells-in-the-presence-of-emu-oil
#12
Minoru Ito, Kazuhiro Minami, Yoshimasa Sagane, Toshihiro Watanabe, Koichi Niwa
Here, we present data on the effects of emu oil, obtained from emu (Dromaius novaehollandiae) fat deposits, on melanogenesis in B16F1 murine melanoma cells. The cells were cultured in media containing different concentrations of emu oil, and the melanin content of these cells was measured using a microplate reader. Next, melanin content was measured for cells cultured with α-melanocyte-stimulating hormone. This article reports the different melanin contents as μg melanin/mg cellular protein, by using bar graphs with error bars...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27919619/microsatellite-polymorphism-located-immediately-upstream-of-the-phosphatidylinositol-glycan-class-k-gene-pigk-affects-its-expression-which-correlates-with-tyrosinase-activity-in-human-melanocytes
#13
Ken Okamura, Masahiro Hayashi, Yuko Abe, Yuta Araki, Yutaka Hozumi, Tamio Suzuki
BACKGROUND: Glycosylphosphatidylinositol (GPI) acts as a membrane anchor and a post-translational modifier for more than 150 proteins (called GPI-anchored proteins: GPI-APs). However, little study has been done to explore the role of GPI-APs in melanocytes. METHODS: The relationship between the mRNA expression of the genes which play essential roles in GPI anchoring system [phosphatidylinositol glycan, class A, and class K gene (PIGA, PIGK)] and melanogenesis-related genes (MITF, TYRP1, TYRP2, and TYR) as well as DOPA oxidase activities were evaluated in 13 different normal human epidermal melanocytes (NHEMs)...
February 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27918305/tuberous-sclerosis-complex-inactivation-disrupts-melanogenesis-via-mtorc1-activation
#14
Juxiang Cao, Magdalena E Tyburczy, Joel Moss, Thomas N Darling, Hans R Widlund, David J Kwiatkowski
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor-suppressor gene syndrome caused by inactivating mutations in either TSC1 or TSC2, and the TSC protein complex is an essential regulator of mTOR complex 1 (mTORC1). Patients with TSC develop hypomelanotic macules (white spots), but the molecular mechanisms underlying their formation are not fully characterized. Using human primary melanocytes and a highly pigmented melanoma cell line, we demonstrate that reduced expression of either TSC1 or TSC2 causes reduced pigmentation through mTORC1 activation, which results in hyperactivation of glycogen synthase kinase 3β (GSK3β), followed by phosphorylation of and loss of β-catenin from the nucleus, thereby reducing expression of microphthalmia-associated transcription factor (MITF), and subsequent reductions in tyrosinase and other genes required for melanogenesis...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27904077/synthesis-characterization-and-evaluation-of-thiazolidine-derivatives-of-cysteine-for-suppressing-eumelanin-production
#15
Yusuke Amino, Yoshinobu Takino, Megumi Kaneko, Fumie Ookura, Mai Yamamoto, Tatsuki Kashiwagi, Keiji Iwasaki
In the pathway of melanin biosynthesis, cysteine (Cys) is utilized for the synthesis of pheomelanin. Accordingly, Cys is considered to suppress the formation of brown-black eumelanin. Although attempts have been made to utilize Cys and its derivatives as skin-whitening agents, their instability and odor hinders their application as a cosmetic agent. Herein, N-acetyl-2-methylthiazolidine-2,4-dicarboxylic acid ethyl ester (AcCP2Et) was proposed as a candidate for a stable and prolonged-release derivative of Cys to inhibit dopachrome formation after its degradation in melanocytes...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27902928/effects-of-aqueous-extracts-of-ecliptae-herba-polygoni-multiflori-radix-praeparata-and-rehmanniae-radix-praeparata-on-melanogenesis-and-the-migration-of-human-melanocytes
#16
Ping Xu, Shulan Su, Cheng Tan, Ren-Sheng Lai, Zhong-Sheng Min
ETHNOPHARMACOLOGICAL RELEVANCE: Polygoni multiflori radix praeparata (PMRP), Ecliptae herba (EH) and Rehmanniae radix praeparata (RRP) are the most frequently-used herbs by Traditional Chinese Medicine practitioners for the treatment of vitiligo. Their abilities to stimulate melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression were evaluated in this study. MATERIALS AND METHODS: The effects of aqueous extracts of PMRP, EH and RRP on human melanocytes in vitro were examined by MTT assay, tyrosinase activity, melanin synthesis, migration assay and Western blot...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27885802/a-novel-p53-pomc-g%C3%AE-s-sash1-autoregulatory-feedback-loop-activates-mutated-sash1-to-cause-pathologic-hyperpigmentation
#17
Ding'an Zhou, Zhiyun Wei, Zhongshu Kuang, Huangchao Luo, Jiangshu Ma, Xing Zeng, Ke Wang, Beizhong Liu, Fang Gong, Jing Wang, Shanchuan Lei, Dongsheng Wang, Jiawei Zeng, Teng Wang, Yong He, Yongqiang Yuan, Hongying Dai, Lin He, Qinghe Xing
p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying the causative gene of dyschromatosis universalis hereditaria (DUH), we found three mutations encoding amino acid substitutions in the gene SAM and SH3 domain containing 1 (SASH1), and SASH1 was associated with guanine nucleotide-binding protein subunit-alpha isoforms short (Gαs)...
November 25, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27882071/pigmentation-effect-of-rice-bran-extracted-minerals-comprising-soluble-silicic-acids
#18
Hyun-Jun Jang, Young-Kwon Seo
Our investigation focused on identifying melanogenesis effect of soluble minerals in rice bran ash extract (RBE) which include orthosilicic acid (OSA). Melanocytes were apparently normal in terms of morphology. It was, however, shown that they were stressed a little in the RBE and OSA added media in aspect of LDH activity. Melanin synthesis and intracellular tyrosinase activity were increased by treatment of RBE which is similar to that of OSA. The Western blotting results showed that TRP-1, tyrosinase, and MITF expression levels were 2-3 times higher in the OSA and RBE groups compared to the control group which promoted melanin synthesis through CREB phosphorylation...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27864061/melanogenesis-inhibits-respiration-in-b16-f10-melanoma-cells-whereas-enhances-mitochondrial-cell-content
#19
Willian Vanderlei Meira, Tassiele Andréa Heinrich, Silvia Maria Suter Correia Cadena, Glaucia Regina Martinez
Melanoma is a rare and aggressive skin tumor; the survival of patients diagnosed late is fairly low. This high mortality rate is due to the characteristics of the cells that allow them to be resistant to radiotherapy and conventional chemotherapy, besides of being able to evade the immune system. Melanin, the pigment responsible for skin, hair and eye color, seems to be involved in this resistance. The main function of melanin is to protect the cells against ultraviolet (UV) light by absorbing this radiation and reactive oxygen species (ROS) scavenging...
January 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/27863303/dihydroresveratrol-cellobioside-and-xylobioside-as-effective-melanogenesis-activators
#20
Chisato Oode, Wataru Shimada, Mariko Yokota, Yoichi Yamada, Ken-Ichi Nihei
Dihydroresveratrol cellobioside and xylobioside, whose structures were designed based on that of the naturally occurring melanogenesis-controlling agent dihydroresveratrol glucoside, were synthesized via Schmidt glycosylation as the key step. Both analogues stimulated melanogenesis with efficacies comparable to that of 8-methoxypsoralen, a well-known melanogenesis activator. This suggests that diglycosyl modification of the 4'-OH on the dihydroresveratrol skeleton leads to the activation of melanogenesis, both with and without hydroxymethyl groups in the sugar moieties...
December 21, 2016: Carbohydrate Research
keyword
keyword
61556
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"