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https://www.readbyqxmd.com/read/27904077/synthesis-characterization-and-evaluation-of-thiazolidine-derivatives-of-cysteine-for-suppressing-eumelanin-production
#1
Yusuke Amino, Yoshinobu Takino, Megumi Kaneko, Fumie Ookura, Mai Yamamoto, Tatsuki Kashiwagi, Keiji Iwasaki
In the pathway of melanin biosynthesis, cysteine (Cys) is utilized for the synthesis of pheomelanin. Accordingly, Cys is considered to suppress the formation of brown-black eumelanin. Although attempts have been made to utilize Cys and its derivatives as skin-whitening agents, their instability and odor hinders their application as a cosmetic agent. Herein, N-acetyl-2-methylthiazolidine-2,4-dicarboxylic acid ethyl ester (AcCP2Et) was proposed as a candidate for a stable and prolonged-release derivative of Cys to inhibit dopachrome formation after its degradation in melanocytes...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27902928/effects-of-aqueous-extracts-of-ecliptae-herba-polygoni-multiflori-radix-praeparata-and-rehmanniae-radix-praeparata-on-melanogenesis-and-the-migration-of-human-melanocytes
#2
Ping Xu, Shulan Su, Cheng Tan, Ren-Sheng Lai, Zhong-Sheng Min
ETHNOPHARMACOLOGICAL RELEVANCE: Polygoni multiflori radix praeparata (PMRP), Ecliptae herba (EH) and Rehmanniae radix praeparata (RRP) are the most frequently-used herbs by Traditional Chinese Medicine practitioners for the treatment of vitiligo. Their abilities to stimulate melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression were evaluated in this study. MATERIALS AND METHODS: The effects of aqueous extracts of PMRP, EH and RRP on human melanocytes in vitro were examined by MTT assay, tyrosinase activity, melanin synthesis, migration assay and Western blot...
November 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27885802/a-novel-p53-pomc-g%C3%AE-s-sash1-autoregulatory-feedback-loop-activates-mutated-sash1-to-cause-pathologic-hyperpigmentation
#3
Ding'an Zhou, Zhiyun Wei, Zhongshu Kuang, Huangchao Luo, Jiangshu Ma, Xing Zeng, Ke Wang, Beizhong Liu, Fang Gong, Jing Wang, Shanchuan Lei, Dongsheng Wang, Jiawei Zeng, Teng Wang, Yong He, Yongqiang Yuan, Hongying Dai, Lin He, Qinghe Xing
p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying the causative gene of dyschromatosis universalis hereditaria (DUH), we found three mutations encoding amino acid substitutions in the gene SAM and SH3 domain containing 1 (SASH1), and SASH1 was associated with guanine nucleotide-binding protein subunit-alpha isoforms short (Gαs)...
November 25, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27882071/pigmentation-effect-of-rice-bran-extracted-minerals-comprising-soluble-silicic-acids
#4
Hyun-Jun Jang, Young-Kwon Seo
Our investigation focused on identifying melanogenesis effect of soluble minerals in rice bran ash extract (RBE) which include orthosilicic acid (OSA). Melanocytes were apparently normal in terms of morphology. It was, however, shown that they were stressed a little in the RBE and OSA added media in aspect of LDH activity. Melanin synthesis and intracellular tyrosinase activity were increased by treatment of RBE which is similar to that of OSA. The Western blotting results showed that TRP-1, tyrosinase, and MITF expression levels were 2-3 times higher in the OSA and RBE groups compared to the control group which promoted melanin synthesis through CREB phosphorylation...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27864061/melanogenesis-inhibits-respiration-in-b16-f10-melanoma-cells-whereas-enhances-mitochondrial-cell-content
#5
Willian Vanderlei Meira, Tassiele Andréa Heinrich, Silvia Maria Suter Correia Cadena, Glaucia Regina Martinez
Melanoma is a rare and aggressive skin tumor; the survival of patients diagnosed late is fairly low. This high mortality rate is due to the characteristics of the cells that allow them to be resistant to radiotherapy and conventional chemotherapy, besides of being able to evade the immune system. Melanin, the pigment responsible for skin, hair and eye color, seems to be involved in this resistance. The main function of melanin is to protect the cells against UV light by absorbing this radiation and ROS scavenging...
November 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27863303/dihydroresveratrol-cellobioside-and-xylobioside-as-effective-melanogenesis-activators
#6
Chisato Oode, Wataru Shimada, Mariko Yokota, Yoichi Yamada, Ken-Ichi Nihei
Dihydroresveratrol cellobioside and xylobioside, whose structures were designed based on that of the naturally occurring melanogenesis-controlling agent dihydroresveratrol glucoside, were synthesized via Schmidt glycosylation as the key step. Both analogues stimulated melanogenesis with efficacies comparable to that of 8-methoxypsoralen, a well-known melanogenesis activator. This suggests that diglycosyl modification of the 4'-OH on the dihydroresveratrol skeleton leads to the activation of melanogenesis, both with and without hydroxymethyl groups in the sugar moieties...
November 9, 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/27856290/enhanced-neurogenic-biomarker-expression-and-reinnervation-in-human-acute-skin-wounds-treated-by-electrical-stimulation
#7
Anil Sebastian, Susan W Volk, Poonam Halai, James Colthurst, Ralf Paus, Ardeshir Bayat
Electrical stimulation (ES) is known to promote cutaneous healing, however its ability to regulate reinnervation remains unclear. Firstly, we show that ES treatment of human acute cutaneous wounds (n=40) increased reinnervation. Next, to define neurophysiological mechanisms through which ES impacts repair, microarray of wound biopsies was performed on days 3, 7, 10 and 14 post-wounding. This identified neural differentiation biomarkers Class III β-tubulin (TUBB3; melanocyte development and neuronal marker) and its upstream molecule Factor Induced Gene 4 (FIG4; phosphatidylinositol (3,5)-bisphosphate 5-phosphatase) as significantly up-regulated post-ES treatment...
November 14, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27851907/the-depigmenting-effect-of-natural-resorcinol-type-polyphenols-kuwanon-o-and-sanggenon-t-from-the-roots-of-morus-australis
#8
Shuting Hu, Zongping Zheng, Feng Chen, Mingfu Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Morus australis, one of the major Morus species growing in East Asia, is rich in phenolic compounds. The extract of M. australis has been used as skin whitening components for a long period. The action mechanisms of its principal constituents are still unclear. This study aims to evaluate the skin lightening effects of phenolic compounds extracted from the root of M. australis in different melanocyte systems and artificial skin models. MATERIALS AND METHODS: The depigmenting effect of resorcinol type polyphenols (RTPs) from the root extract of M...
November 13, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27846817/micrornas-regulate-gene-plasticity-during-cold-shock-in-zebrafish-larvae
#9
I-Chen Hung, Yu-Chuan Hsiao, H Sunny Sun, Tsung-Ming Chen, Shyh-Jye Lee
BACKGROUND: MicroRNAs (miRNAs) are critical regulators responding to acute environmental stresses in both plants and animals. By modulating gene expression, miRNAs either restore or reconstitute a new expression program to enhance cell tolerance to stresses. Cold shock is one of the stresses that can induce acute physiological responses and transcriptional changes in aquatic creatures. Previous genomic studies have revealed many cold-affected genes in fish larvae and adults, however, the role of miRNAs in acute cold response is still ambiguous...
November 15, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27835883/ranbpm-ranbp9-regulates-mouse-c-kit-receptor-level-and-is-essential-for-normal-development-of-bone-marrow-progenitor-cells
#10
Sandrine Puverel, Erkan Kiris, Satyendra Singh, Kimberly D Klarmann, Vincenzo Coppola, Jonathan R Keller, Lino Tessarollo
c-Kit is a tyrosine kinase receptor important for gametogenesis, hematopoiesis, melanogenesis and mast cell biology. Dysregulation of c-Kit function is oncogenic and its expression in the stem cell niche of a number of tissues has underlined its relevance for regenerative medicine and hematopoietic stem cell biology. Yet, very little is known about the mechanisms that control c-Kit protein levels. Here we show that the RanBPM/RanBP9 scaffold protein binds to c-Kit and is necessary for normal c-Kit protein expression in the mouse testis and subset lineages of the hematopoietic system...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835606/neurokinin-1-receptor-is-a-novel-positive-regulator-of-wnt-%C3%AE-catenin-signaling-in-melanogenesis
#11
Jia Zhou, Jingjing Ling, Huizhu Song, Bei Lv, Lei Wang, Jing Shang, Yong Wang, Chunyan Chang, Fengfeng Ping, Jun Qian
Wnt/β-catenin signaling is essential for melanogenesis in melanocytes. Neurokinin-1 receptor (NK-1R) has recently been demonstrated to be involved in melanin production. However, the cross talk between NK-1R and Wnt/β-catenin is poorly understood. Here, [Sar9, Met(O2)11] substance P (SMSP) was used to activate NK-1R, while L-733060 was used to inhibit it. The effects of NK-1R activation and inhibition on Wnt and its inhibitors were analyzed using western blot and real-time quantitative PCR. The results showed that SMSP positively regulated Wnt/β-catenin signaling by increasing the expression of β-catenin and p-GSK3β protein, which resulted from the weakened expression of the Wnt inhibitor Dickkopf-1 (DKK1)...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832141/thyroid-hormones-regulate-zebrafish-melanogenesis-in-a-gender-specific-manner
#12
Raúl Guillot, Borja Muriach, Ana Rocha, Josep Rotllant, Robert N Kelsh, José Miguel Cerdá-Reverter
Zebrafish embryos are treated with anti-thyroidal compounds, such as phenylthiourea, to inhibit melanogenesis. However, the mechanism whereby the thyroidal system controls melanin synthesis has not been assessed in detail. In this work, we tested the effect of the administration of diets supplemented with T3 (500μg/g food) on the pigment pattern of adult zebrafish. Oral T3 induced a pronounced skin paling in both adult female and male zebrafish that was reversible upon cessation of treatment. The number of visible melanophores was significantly reduced in treated fish...
2016: PloS One
https://www.readbyqxmd.com/read/27827938/anti-melanogenic-activities-of-heracleum-moellendorffii-via-erk1-2-mediated-mitf-downregulation
#13
Md Badrul Alam, Bum-Ju Seo, Peijun Zhao, Sang-Han Lee
In this study, the anti-melanogenic effects of Heracleum moellendorffii Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in melan-a cells were investigated. Mushroom tyrosinase (TYR) activity and melanin content as well as cellular tyrosinase activity were measured in the cells. mRNA and protein expression of microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), TYR-related protein-1 (TYRP-1) and -2 were also examined. The results demonstrate that treatment with HmHe significantly inhibits mushroom tyrosinase activity...
November 4, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27801787/effects-of-ganodermanondiol-a-new-melanogenesis-inhibitor-from-the-medicinal-mushroom-ganoderma-lucidum
#14
Ji-Woong Kim, Hong-Il Kim, Jong-Hyeon Kim, O-Chul Kwon, Eun-Suk Son, Chang-Soo Lee, Young-Jin Park
Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variety of biological activities and great potential as an ingredient in skin care cosmetics including "skin-whitening" products. However, there is little information available on its inhibitory effect against tyrosinase activity. Therefore, the objectives of this study were to investigate the chemical composition of G. lucidum and its inhibitory effects on melanogenesis. We isolated the active compound from G...
October 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27787879/impact-of-hmgb1-on-melanocytic-survival-and-its-involvement-in-the-pathogenesis-of-vitiligo
#15
J Y Kim, E J Lee, J Seo, S H Oh
BACKGROUND: Vitiligo is attributable to loss of functional melanocytes and is the most common acquired depigmenting disorder. Oxidative stress and intense UV irradiation are known to aggravate this condition. The non-histone high mobility group box 1 (HMGB1) DNA binding protein is a physiologic activator of immune responses, cellular proliferation, and cell death. Although implicated in the pathogenesis of autoimmune diseases and cutaneous disorders, the precise role of HMGB1 in melanocytes has yet to be studied...
October 27, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27775611/critical-analysis-of-the-melanogenic-pathway-in-insects-and-higher-animals
#16
Manickam Sugumaran, Hanine Barek
Animals synthesize melanin pigments for the coloration of their skin and use it for their protection from harmful solar radiation. Insects use melanins even more ingeniously than mammals and employ them for exoskeletal pigmentation, cuticular hardening, wound healing and innate immune responses. In this review, we discuss the biochemistry of melanogenesis process occurring in higher animals and insects. A special attention is given to number of aspects that are not previously brought to light: (1) the molecular mechanism of dopachrome conversion that leads to the production of two different dihydroxyindoles; (2) the role of catecholamine derivatives other than dopa in melanin production in animals; (3) the critical parts played by various biosynthetic enzymes associated with insect melanogenesis; and (4) the presence of a number of important gaps in both melanogenic and sclerotinogenic pathways...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27774936/-toll-like-receptor-4-activation-inhibits-melanogenesis-in-melanocytes
#17
Lijun Sun, Jingying Sun, Xueping Huo, Yaping Li, Yuan Li, Xin Xie, Jun Hu
Objective To explore the effect of Toll-like receptor 4 (TLR4) activation on melanogenesis in melanocytes. Methods The primary melanocytes were isolated, cultured and then stimulated by TLR4 agonist lipopolysaccharide (LPS). Firstly, the melanin content changes were detected in melanocytes, and then quantitative real-time PCR and Western blotting were employed to determine the expression levels of pre-melanosomal protein (Pmel17), tyrosinase (TYR) and microphthalmia-associated transcription factor (MITF). Finally, the melanosomes were observed by electron microscopy...
November 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27770559/fluorescent-quantification-of-melanin
#18
Bruno Fernandes, Teresa Matamá, Diana Guimarães, Andreia Gomes, Artur Cavaco-Paulo
Melanin quantification is reportedly performed by absorption spectroscopy, commonly at 405 nm. Here, we propose the implementation of fluorescence spectroscopy for melanin assessment. In a typical in vitro assay to assess melanin production in response to an external stimulus, absorption spectroscopy clearly overvalues melanin content. This method is also incapable of distinguishing non-melanotic/amelanotic control cells from those that are actually capable of performing melanogenesis. Therefore, fluorescence spectroscopy is the best method for melanin quantification as it proved to be highly specific and accurate, detecting even small variations in the synthesis of melanin...
November 2016: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27761938/cutaneous-malignant-melanoma-and-parkinson-disease-common-pathways
#19
REVIEW
Rivka Inzelberg, Shira Flash, Eitan Friedman, Esther Azizi
The mechanisms underlying the high prevalence of cutaneous malignant melanoma (CMM) in Parkinson disease (PD) are unclear, but plausibly involve common pathways. 129Ser-phosphorylated α-synuclein, a pathological PD hallmark, is abundantly expressed in CMM, but not in normal skin. In inherited PD, PARK genes harbor germline mutations; the same genes are somatically mutated in CMM, or their encoded proteins are involved in melanomagenesis. Conversely, genes associated with CMM affect PD risk. PD/CMM-targeted cells share neural crest origin and melanogenesis capability...
October 19, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27756508/melanogenesis-inhibitory-activity-of-a-7-o-9-linked-neolignan-from-alpinia-galanga-fruit
#20
Yoshiaki Manse, Kiyofumi Ninomiya, Ryosuke Nishi, Iyori Kamei, Yushi Katsuyama, Takahito Imagawa, Saowanee Chaipech, Osamu Muraoka, Toshio Morikawa
An aqueous acetone extract from the fruit of Alpinia galanga (Zingiberaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells (IC50=7.3μg/mL). Through bioassay-guided separation of the extract, a new 7-O-9'-linked neolignan, named galanganol D diacetate (1), was isolated along with 16 known compounds including 14 phenylpropanoids (2-15). The structure of 1, including its absolute stereochemistry in the C-7 position, was elucidated by means of extensive NMR analysis and total synthesis...
October 6, 2016: Bioorganic & Medicinal Chemistry
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