keyword
MENU ▼
Read by QxMD icon Read
search

melanogenesis

keyword
https://www.readbyqxmd.com/read/28204812/the-lactoferricin-b-derived-peptide-lfb17-34-induces-melanogenesis-in-b16f10-cells
#1
Hsiu-Chin Huang, Hsuan Lin, Min-Chuan Huang
Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. We found that LfB17‑34, an 18-mer LfcinB-derived peptide, increased melanogenesis in B16F10 melanoma cells without significantly affecting cell viability. LfB17‑34 increased in vitro tyrosinase activity and melanin content in a dose-dependent manner...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28192140/action-of-2-2-4-4-tetrahydroxybenzophenone-in-the-biosynthesis-pathway-of-melanin
#2
Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Pedro Antonio Garcia-Ruiz, Jose Berna, Jose Neptuno Rodríguez-López, Jose Tudela, Francisco Garcia-Canovas
2,2',4,4'-tetrahydroxybenzophenone (Uvinul D50), a sunscreen used in cosmetics, has two effects in the melanin biosynthesis pathway. On the one hand, it acts a weak inhibitor of tyrosinase and on the other, it accelerates the conversion of dopachrome to melanin. Uvinul D50 was seen to behave as a weak competitive inhibitor: apparent constant inhibition=2.02±0.09mM and IC50=3.82±0.39mM established in this work. These values are higher than those in the bibliography, which tend to be undersetimated. This discrepancy could be explained by the reaction of Uvinul D50 with the dopachrome produced from l-tyrosine or l-dopa, which would interfere in the measurement...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28185012/the-synergistic-effect-of-maltose-enhances-the-anti-melanogenic-activity-of-acarbose
#3
Bum-Ho Bin, Sung Tae Kim, Jinhyuk Bhin, Kyounghee Byoun, Tae Ryong Lee, Eun-Gyung Cho
Melanocytes play an important role in maintaining epidermal homeostasis by producing melanin and protecting the skin from harmful environmental factors. However, excessive up- or down-regulation of melanin production often causes hyper- or hypo-pigmented disorders, respectively, which affect the patient's quality of life. Therefore, various strategies for modulating melanin levels have been developed by the pharmaceutical and cosmetic industries. We reported previously that voglibose, which is a well-known anti-hyperglycemic agent, could be used as an anti-melanogenic agent by inhibiting α-glucosidase activity and reducing tyrosinase protein levels...
February 9, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28182699/bifunctional-effects-of-o-methylated-flavones-from-scutellaria-baicalensis-georgi-on-melanocytes-inhibition-of-melanin-production-and-intracellular-melanosome-transport
#4
Michiko Kudo, Kumiko Kobayashi-Nakamura, Kentaro Tsuji-Naito
The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect on melanogenesis; (2) wogonin and its glycoside are the active components of S. baicalensis; and (3) O-methylated flavones from S. baicalensis, such as wogonin, inhibit intracellular melanosome transport...
2017: PloS One
https://www.readbyqxmd.com/read/28174022/the-evolution-and-genetics-of-carotenoid-processing-in-animals
#5
REVIEW
David P L Toews, Natalie R Hofmeister, Scott A Taylor
Coloration is one of the most conspicuous traits that varies among organisms. Carotenoid pigments are responsible for many of the red, orange, and yellow colors in the natural world and, at least for most animals, these molecules must be acquired from their environment. Identifying genes important for carotenoid transport, deposition, and processing has been difficult, in contrast to the well-characterized genes involved in the melanogenesis pathways. We review recent progress in the genetics of carotenoid processing, advances owing in part to the application of high-throughput sequencing data...
February 4, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28165370/plumbagin-suppresses-%C3%AE-msh-induced-melanogenesis-in-b16f10-mouse-melanoma-cells-by-inhibiting-tyrosinase-activity
#6
Taek-In Oh, Jeong-Mi Yun, Eun-Ji Park, Young-Seon Kim, Yoon-Mi Lee, Ji-Hong Lim
Recent studies have shown that plumbagin has anti-inflammatory, anti-allergic, antibacterial, and anti-cancer activities; however, it has not yet been shown whether plumbagin suppresses alpha-melanocyte stimulating hormone (α-MSH)-induced melanin synthesis to prevent hyperpigmentation. In this study, we demonstrated that plumbagin significantly suppresses α-MSH-stimulated melanin synthesis in B16F10 mouse melanoma cells. To understand the inhibitory mechanism of plumbagin on melanin synthesis, we performed cellular or cell-free tyrosinase activity assays and analyzed melanogenesis-related gene expression...
February 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28165285/lactoferrin-inhibits-melanogenesis-by-down-regulating-mitf-in-melanoma-cells-and-normal-melanocytes
#7
Nanase Ishii, Mizuyuki Ryu, Yasushi A Suzuki
The aim of this study was to evaluate the effect of bovine lactoferrin (bLf) on melanin-producing cells and to elucidate its mechanism of action. We tested the anti-melanogenic effect of bLf on a 3-dimensional cultured pigmentation skin model and confirmed a 20% reduction in pigmentation, suggesting that bLf was transdermally absorbed and it suppressed melanin production. Treatment of human melanoma cells with bLf resulted in a significant, dose-dependent suppression of melanin production. Apo-bLf and holo-bLf suppressed melanogenesis to the same degree as bLf...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28152530/the-preventive-effect-of-coffee-compounds-on-dermatitis-and-epidermal-pigmentation-after-ultraviolet-irradiation-in-mice
#8
Yurika Yamate, Keiichi Hiramoto, Eisuke F Sato
BACKGROUND: Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS: C57BL/6j male mice were irradiated with UVB (1.0 kJ/m2/day) for 3 days. Five days after the final session of UVB irradiation, the dorsal skin, ear epidermis, and blood samples were analyzed to investigate the inflammatory factors, melanogenesis factors and related hormones...
February 3, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28133910/tranexamic-acid-in-treatment-of-melasma-a-comprehensive-review-of-clinical-studies
#9
REVIEW
Mohammad Taraz, Somayeh Niknam, Amir Houshang Ehsani
Melasma is a human melanogenesis dysfunction that results in localized, chronic acquired hyperpigmentation of the skin. It has a significant impact on appearance, causing psychosocial and emotional distress, and reducing the quality of life of the affected patients. Tranexamic acid (TA) is a plasmin inhibitor used to prevent abnormal fibrinolysis to reduce blood loss and exerts its effect by reversibly blocking lysine binding sites on plasminogen molecules, thus inhibiting plasminogen activator (PA) from converting plasminogen to plasmin...
January 30, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28130732/zebrafish-phosvitin-derived-peptide-pt5-inhibits-melanogenesis-via-camp-pathway
#10
Yuan-Yuan Liu, Xiu-Rong Su, Shou-Sheng Liu, Shuang-Shuang Yang, Cheng-Yan Jiang, Yu Zhang, Shicui Zhang
Zebrafish phosvitin-derived peptide Pt5, consisting of the C-terminal 55 residues of phosvitin, has been shown to have an antimicrobial-immunomodulatory activity comparable to phosvitin. Here, we showed clearly that Pt5 had the capacity to inhibit tyrosinase (TYR) activity and melanin biosynthesis, and this inhibition was independent of cell proliferation and cytotoxic effects. Incubation of fluorescein isothiocyanate (FITC)-labeled Pt5 with B16F10 melanoma cells revealed that Pt5 was localized in the cytoplasm of the cells...
January 27, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28127878/melanin-is-effective-in-protecting-fast-and-slow-growing-fungi-from-various-types-of-ionizing-radiation
#11
Claudia Pacelli, Ruth A Bryan, Silvano Onofri, Laura Selbmann, Igor Shuryak, Ekaterina Dadachova
Melanin is a ubiquitous pigment with unique physicochemical properties. The resistance of melanized fungi to cosmic and terrestrial ionizing radiation suggests that melanin also plays a pivotal role in radioprotection. In this study, we compared the effects of densely-ionizing deuterons and sparsely-ionizing X-rays on two microscopic fungi capable of melanogenesis. We utilized the fast-growing pathogenic basiodiomycete forming an induced DOPA-melanin, Cryptococcus neoformans (CN); and the slow-growing environmental rock-inhabiting ascomycete synthesizing a constitutive DHN-melanin, Cryomyces antarcticus (CA); melanized and non-melanized counterparts were compared...
January 27, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28114924/n-4-methoxyphenyl-caffeamide-induced-melanogenesis-inhibition-mechanisms
#12
Yueh-Hsiung Kuo, Chien-Chia Chen, Po-Yuan Wu, Chin-Sheng Wu, Ping-Jyun Sung, Chien-Yih Lin, Hsiu-Mei Chiang
BACKGROUND: The derivative of caffeamide exhibits antioxidant and antityrosinase activity. The activity and mechanism of N-(4-methoxyphenyl) caffeamide (K36E) on melanogenesis was investigated. METHODS: B16F0 cells were treated with various concentrations of K36E; the melanin contents and related signal transduction were studied. Western blotting assay was applied to determine the protein expression, and spectrophotometry was performed to identify the tyrosinase activity and melanin content...
January 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28114343/acerola-malpighia-emarginata-dc-juice-intake-suppresses-uvb-induced-skin-pigmentation-in-smp30-gnl-knockout-hairless-mice
#13
Yasunori Sato, Eriko Uchida, Hitoshi Aoki, Takayuki Hanamura, Kenichi Nagamine, Hisanori Kato, Takeshi Koizumi, Akihito Ishigami
BACKGROUND/AIMS: Acerola (Malpighia emarginata DC.) is a fruit that is known to contain high amounts of ascorbic acid (AA) and various phytochemicals. We have previously reported that AA deficiency leads to ultraviolet B (UVB)-induced skin pigmentation in senescence marker protein 30 (SMP30)/gluconolactonase (GNL) knockout (KO) hairless mice. The present study was undertaken to investigate the effects of acerola juice (AJ) intake on the skin of UVB-irradiated SMP30/GNL KO mice. RESEARCH DESIGN/PRINCIPAL FINDINGS: Five-week old hairless mice were given drinking water containing physiologically sufficient AA (1...
2017: PloS One
https://www.readbyqxmd.com/read/28105275/2-hydroxypyridine-n-oxide-embedded-aurones-as-potent-human-tyrosinase-inhibitors
#14
Romain Haudecoeur, Marcello Carotti, Aurélie Gouron, Marc Maresca, Elina Buitrago, Renaud Hardré, Elisabetta Bergantino, Hélène Jamet, Catherine Belle, Marius Réglier, Luigi Bubacco, Ahcène Boumendjel
With the aim to develop effective and selective human tyrosinase inhibitors, we investigated aurone derivatives whose B-ring was replaced by a non-oxidizable 2-hydroxypyridine-N-oxide (HOPNO) moiety. These aurones were synthesized and evaluated as inhibitors of purified human tyrosinase. Excellent inhibition activity was revealed and rationalized by theoretical calculations. The aurone backbone was especially found to play a crucial role, as the HOPNO moiety alone provided very modest activity on human tyrosinase...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28104549/mechanisms-of-silver_nanoparticles-induced-hypopigmentation-in-embryonic-zebrafish
#15
Lian Xu, Qin-Han Xu, Xin-Ying Zhou, Li-Yan Yin, Peng-Peng Guan, Ting Zhang, Jing-Xia Liu
Silver_nanoparticles (AgNPs) have been reported to inhibit specification of erythroid cells and to induce spinal cord deformities and cardiac arrhythmia in vertebrates, but have not been implicated in development of neural crest (NC) and pigment cells in an in vivo model yet. In current study, down-regulated expressions of NC genes pax7 and foxd3, melanophore genes mitfa and dct, and xanthophore gene gch2 in AgNPs-exposed embryos were revealed by microarray, qRT-PCR and whole-mount in situ hybridization (WISH)...
March 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28098220/comparative-transcriptome-analysis-of-raccoon-dog-skin-to-determine-melanin-content-in-hair-and-melanin-distribution-in-skin
#16
Zhanyu Du, Kai Huang, Jiaping Zhao, Xingchao Song, Xiumei Xing, Qiong Wu, Linbo Zhang, Chao Xu
The raccoon dog (Nyctereutes procyonoides) is an important canid fur-bearing animal species worldwide. Chinese raccoon dogs that present a white mutation, especially those with a white coat. Exploring melanin biosynthesis in the hair and skin of raccoon dogs is important for understanding the survival and evolutionary mechanisms of them. In this study, we measured the content of melanin in the hair of two types of raccoon dog and generated stained slices of skin tissue. The results indicated that melanin biosynthesis occurs in the wild-type (W) and white-type (B) raccoon dog skin, although less melanin is produced in B skin...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097901/skin-whitening-agents-medicinal-chemistry-perspective-of-tyrosinase-inhibitors
#17
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 played a major role in melanin synthesis. Specifically, tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin synthesis, and the downregulation of tyrosinase is the most prominent approach for the development of melanogenesis inhibitors...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28095579/development-and-clinical-assessment-of-a-comprehensive-product-for-pigmentation-control-in-multiple-ethnic-populations
#18
Elizabeth T Makino, Kuniko Kadoya, Monya L Sigler, Peter D Hino, Rahul C Mehta
BACKGROUND: Pigmentary changes in people of different ethnic origins are controlled by slight variations in key biological pathways leading to different outcomes from the same treatment. It is important to develop and test products for desired outcomes in varying ethnic populations. OBJECTIVES: To develop a comprehensive product (LYT2) that affects all major biological pathways controlling pigmentation and test for clinical efficacy and safety in different ethnic populations...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28051915/alisol-b-a-triterpene-from-alismatis-rhizoma-dried-rhizome-of-alisma-orientale-inhibits-melanin-production-in-murine-b16-melanoma-cells
#19
Ichiro Yoshida, Chihiro Ito, Shinya Matsuda, Akihiko Tsuji, Noriyuki Yanaka, Keizo Yuasa
To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis...
January 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28033525/dietary-polychlorinated-biphenyls-long-chain-n-3-polyunsaturated-fatty-acids-and-incidence-of-malignant-melanoma
#20
Carolina Donat-Vargas, Marika Berglund, Anders Glynn, Alicja Wolk, Agneta Åkesson
BACKGROUND: For malignant melanoma, other risk factors aside from sun exposure have been hardly explored. Polychlorinated biphenyls (PCBs)-mainly from fatty fish- may affect melanogenesis and promote melanoma progression, while long-chain n-3 polyunsaturated fatty acids seem to exert antineoplastic actions in melanoma cells. OBJECTIVES: We aimed to assess the association of validated estimates of dietary PCB exposure as well as the intake of eicosapentaenoic acid and docosahexaenoic acid (EPA-DHA), accounting for sun habits and skin type, with the risk of malignant melanoma in middle-aged and elderly women...
December 26, 2016: European Journal of Cancer
keyword
keyword
61556
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"