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https://www.readbyqxmd.com/read/29237384/ros-scavenging-and-anti-tyrosinase-properties-of-crocetin-on-b16f10-murine-melanoma-cells
#1
Seyed Hamed Hashemi-Shahri, Alireza Golshan, Seyed Ahmad Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar, Zahra Tayarani-Najaran
BACKGROUND: Crocus sativus (Iridaceae) has been traditionally used in the Iranian folk medicine and as a culinary additive. Major components of the plant that are responsible for biological properties are saffranal, crocin, picrocrocin and crocetin. Although the level of crocetin is not high, some of the important activities of saffron such as antioxidant activity have been attributed to crocetin. OBJECTIVE: In the present study, we investigated the effects of crocetin on melanogenesis in B16 melanoma cells...
December 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29232889/preparation-characterization-and-biological-activities-of-topical-anti-aging-ingredients-in-a-citrus-junos-callus-extract
#2
Deepak Adhikari, Vijay Kumar Panthi, Rudra Pangeni, Hyun Jung Kim, Jin Woo Park
In this study, we prepared and characterized a callus extract from Citrus junos and assessed its utility as a source of topical anti-aging ingredients. Callus extract was produced by aqueous extraction from Citrus junos grown on Murashige and Skoog medium with picloram as a growth regulator. After measuring the total phenolic and flavonoid contents, the major phenolic compound in calli was identified as p-hydroxycinnamoylmalic acid (1) by spectroscopic analysis. The total phenol content in the extract was determined to be 24...
December 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29230879/microrna-143-5p-regulates-alpaca-melanocyte-migration-proliferation-and-melanogenesis
#3
Kaiyuan Ji, Pengqian Zhang, Junzhen Zhang, Ruiwen Fan, Yu Liu, Shanshan Yang, Shuaipeng Hu, Xuexian Liu, Changsheng Dong
microRNAs (miRNAs) have been shown to be closely involved in the control of melanogenesis and hair colour in mammals. Previous data also indicate that miR-143 regulates cell growth in melanoma. Here, we aimed to investigate the role of miR-143-5p in alpaca melanocytes. We found that miR-143-5p was highly expressed in the cytoplasm of alpaca melanocytes as demonstrated by an in situ hybridization assay. Prediction analysis revealed that miR-143-5p could regulate TGF-β-activated kinase 1 (TAK1) expression, which we confirmed by luciferase reporter assay, indicating that miR-143-5p controls TAK1 expression by directly targeting its 3' untranslated region (UTR)...
December 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29207659/2-3-4-dihydroxybenzylidene-malononitrile-as-a-novel-anti-melanogenic-compound
#4
Bonggi Lee, Kyoung Mi Moon, Jong Seung Lim, Yeojin Park, Do Hyun Kim, Sujin Son, Hyoung Oh Jeong, Dae Hyun Kim, Eun Kyeong Lee, Ki Wung Chung, Hye Jin An, Pusoon Chun, Arnold Y Seo, Ju-Hye Yang, Bong-Seon Lee, Jin Yeul Ma, Won-Kyung Cho, Hyung Ryong Moon, Hae Young Chung
Tyrosinase is a key player in ultraviolet-induced melanogenesis. Because excessive melanin accumulation in the skin can induce hyperpigmentation, the development of tyrosinase inhibitors has attracted attention in cosmetic-related fields. However, side effects including toxicity and low selectivity have limited the use of many tyrosinase inhibitors in cosmetics. We synthesized 12 novel 2-(substituted benzylidene)malononitrile derivatives and investigated their anti-melanogenic activities. Of these 12 compounds, 2-(3, 4-dihydroxy benzylidene)malononitrile (BMN11) exhibited the strongest inhibitory activity against tyrosinase (IC50 = 17...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207077/investigation-of-the-pro-apoptotic-effects-of-arbutin-and-its-acetylated-derivative-on-murine-melanoma-cells
#5
Liyan Jiang, Di Wang, Yongfeng Zhang, Junyang Li, Zhiping Wu, Zhi Wang, Di Wang
Arbutin, a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses whitening and anticancer properties. The effects of arbutin on melanogenesis and its pro-apoptotic effect on B16 murine melanoma cells have not yet been reported. In the present study, acetylated arbutin was prepared in order to improve the biological effects of arbutin, and it was found to significantly inhibit the biosynthesis of melanin and tyrosinase activity compared with parent arbutin in B16 murine melanoma cells...
November 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29187213/jmjd6-promotes-melanoma-carcinogenesis-through-regulation-of-the-alternative-splicing-of-pak1-a-key-mapk-signaling-component
#6
Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun
BACKGROUND: Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway play critical roles in the pathogenesis of melanoma, how the MAPK signaling is regulated in melanoma carcinogenesis is still not fully understood. METHODS: We characterized JMJD6 expression in melanoma tissue array by immunohistochemistry analysis...
November 29, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29186858/differential-expression-of-nitric-oxide-synthase-isoforms-nnos-and-inos-in-patients-with-non-segmental-generalized-vitiligo
#7
Mario Vaccaro, Natasha Irrera, Giuseppina Cutroneo, Giuseppina Rizzo, Federico Vaccaro, Giuseppe P Anastasi, Francesco Borgia, Serafinella P Cannavò, Domenica Altavilla, Francesco Squadrito
Nitric oxide (NO) is involved in several biological processes, but its role in human melanogenesis is still not well understood. Exposure to UVA and UVB induces nitric oxide production in keratinocytes and melanocytes through the activation of constitutive nitric oxide synthase, increasing tyrosinase activity and melanin synthesis, whereas inducible nitric oxide synthase over expression might be involved in hypopigmentary disorders. The aim of this study was to evaluate whether inducible nitric oxide synthase and neuronal nitric oxide synthase expression were modified in vitiligo skin compared to healthy controls...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29182558/an-isoxazole-chalcone-derivative-enhances-melanogenesis-in-b16-melanoma-cells-via-the-akt-gsk3%C3%AE-%C3%AE-catenin-signaling-pathways
#8
Li Yin, Chao Niu, Li-Xin Liao, Jun Dou, Maidina Habasi, Haji Akber Aisa
Plants or plant-derived products have been routinely used in several traditional medicine systems for vitiligo treatment. It is well-known that melanogenesis can be promoted by certain flavonoid compounds isolated from the traditional Uyghur medicinal plant, Kaliziri. Therefore, Chalcones, one class of flavonoid compounds, has become an interesting target for the development of anti-vitiligo agents. A series of novel isoxazole chalcone derivatives have been designed, synthesized, and evaluated for biological activities by our group...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29179564/chemical-components-of-hyssopus-seravshanicus-antioxidant-activity-activations-of-melanogenesis-and-tyrosinase-and-quantitative-determination-by-uplc-dad
#9
Omina Shomirzoeva, Jun Li, Sodik Numonov, Nuramina Mamat, Dilireba Shataer, Xueying Lu, Haji Abker Aisa
Hyssopus seravshanicus (Dubj.) Pazij has been used as traditional herb and food due to its wide biological properties. Seventeen known compounds were isolated from the ethyl acetate fraction. Their structures were identified by spectroscopic data and comparison with published data. Among them, 14 ones were identified from H. seravshanicus for the first time. DPPH and ABTS radical scavenging activities for crude ethanol extract (CEE), ethyl acetate fraction (EAF), butanol fraction (BF) and compounds 1, 3, 8, 10, 11 and 13 were performed...
November 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29168273/synergistic-inhibition-of-cell-proliferation-by-combined-targeting-with-kinase-inhibitors-and-dietary-xanthone-is-a-promising-strategy-for-melanoma-treatment
#10
Y Xia, J Sun
α-Mangostin is a dietary xanthone that displays various biological activities, and numerous reports have shown its efficacy in cancer prevention and inhibition. As most agents have been shown to be ineffective as single-agent therapy for malignant melanoma (MM), the principle of targeted chemotherapy for MM is to use effective inhibitors and combination methods. In this study, we tested the cytotoxicity of several kinase inhibitors, including the glycogen synthase kinase (GSK)-3 inhibitor CHIR99021, and rapamycin, in combination with a dietary xanthone, α-mangostin, by screening from a kinase inhibitor library for melanogenesis in SK-MEL-2 MM cells, and verified these by clone formation efficiency, terminal dUTP nick end labelling, and expression of apoptosis-related proteins...
November 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29145845/network-pharmacological-mechanisms-of-vernonia-anthelmintica-l-in-the-treatment-of-vitiligo-isorhamnetin-induction-of-melanogenesis-via-up-regulation-of-melanin-biosynthetic-genes
#11
Ji Ye Wang, Hong Chen, Yin Yin Wang, Xiao Qin Wang, Han Ying Chen, Mei Zhang, Yun Tang, Bo Zhang
BACKGROUND: Vitiligo is a long-term skin disease characterized by the loss of pigment in the skin. The current therapeutic approaches are limited. Although the anti-vitiligo mechanisms of Vernonia anthelmintica (L.) remain ambiguous, the herb has been broadly used in Uyghur hospitals to treat vitiligo. The overall objective of the present study aims to identify the potential lead compounds from Vernonia anthelmintica (L.) in the treatment of vitiligo via an oral route as well as the melanogenic mechanisms in the systematic approaches in silico of admetSAR and substructure-drug-target network-based inference (SDTNBI)...
November 16, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29144597/melanogenesis-inhibitory-and-cytotoxic-activities-of-chemical-constituents-from-the-leaves-of-sauropus-androgynus-l-merr-euphorbiaceae
#12
Jie Zhang, Wan-Fang Zhu, Wei-Yuan Zhu, Pan Pan Yang, Jian Xu, Jiradej Manosroi, Takashi Kikuchi, Masahiko Abe, Toshihiro Akihisa, Feng Feng
A new steroid, 20-hydroxyisofucosterol (stigmasta-5,24(28)-diene-3β,20β-diol) (7), along with six known compounds 1 - 6 were isolated from the MeOH extract of the leaves of Sauropus androgynus L. Merr. (Euphorbiaceae). The structure of new steroid was determined by HR-APCI-MS and various NMR techniques in combination with literature data. Subsequently, their anti-inflammatory, cytotoxic activities against five human cell lines, as well as inhibitory activities against the α-MSH induced melanogenesis on the B16 cell line were evaluated...
November 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29124496/biological-activity-of-entada-phaseoloides-and-entada-rheedei
#13
REVIEW
Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka
The aim of our study is to find functional compounds from natural resources. We focus on plants grown in tropical areas, especially Madagascar and Thailand, because they have unique flora and are expected to contain interesting compounds. We review the functional compounds of the seed kernels of Entada phaseoloides and E. rheedei and their biological activities such as anti-proliferation and melanogenesis inhibitory properties, etc.
November 9, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29121864/comparative-transcriptome-and-dna-methylation-analyses-of-the-molecular-mechanisms-underlying-skin-color-variations-in-crucian-carp-carassius-carassius-l
#14
Yongqin Zhang, Jinhui Liu, Wen Fu, Wenting Xu, Huiqin Zhang, Shujuan Chen, Wenbin Liu, Liangyue Peng, Yamei Xiao
BACKGROUND: Crucian carp is a popular ornamental strain in Asia with variants in body color. To further explore the genetic mechanisms underlying gray and red body color formation in crucian carp, the skin transcriptomes and partial DNA methylation sites were obtained from red crucian carp (RCC) and white crucian carp (WCC). Here, we show significant differences in mRNA expression and DNA methylation sites between skin tissues of RCC and WCC. RESULTS: Totals of 3434 and 3683 unigenes had significantly lower and higher expression in WCC, respectively, compared with unigenes expressed in RCC...
November 9, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29121440/d-tyrosine-negatively-regulates-melanin-synthesis-by-competitively-inhibiting-tyrosinase-activity
#15
Jisu Park, Hyejung Jung, Kyuri Kim, Kyung-Min Lim, Ji-Young Kim, Eek-Hoon Jho, Eok-Soo Oh
Although L-tyrosine is well known for its melanogenic effect, the contribution of D-tyrosine to melanin synthesis was previously unexplored. Here, we reveal that, unlike L-tyrosine, D-tyrosine dose-dependently reduced the melanin contents of human MNT-1 melanoma cells and primary human melanocytes. In addition, 500 μM of D-tyrosine completely inhibited 10 μM L-tyrosine-induced melanogenesis, and both in vitro assays and L-DOPA staining MNT-1 cells showed that tyrosinase activity is reduced by D-tyrosine treatment...
November 9, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29115496/prenatal-diagnosis-and-genetic-counseling%C3%A2-for-waardenburg-syndrome-type%C3%A2-i-and-ii-in-chinese-families
#16
Li Wang, Litao Qin, Tao Li, Hongjian Liu, Lingcao Ma, Wan Li, Dong Wu, Hongdan Wang, Qiannan Guo, Liangjie Guo, Shixiu Liao
Waardenburg syndrome (WS) is an auditory‑pigmentary disorder with varying combinations of sensorineural hearing loss and abnormal pigmentation. The present study aimed to investigate the underlying molecular pathology and provide a method of prenatal diagnosis of WS in Chinese families. A total of 11 patients with WS from five unrelated Chinese families were enrolled. A thorough clinical examination was performed on all participants. Furthermore, patients with WS underwent screening for mutations in the following genes: Paired box 3 (PAX3), melanogenesis associated transcription factor (MITF), SRY‑box 10, snail family transcriptional repressor 2 and endothelin receptor type B using polymerase chain reaction sequencing...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115012/3-o-glyceryl-2-o-hexyl-ascorbate-suppresses-melanogenesis-by-interfering-with-intracellular-melanosome-transport-and-suppressing-tyrosinase-protein-synthesis
#17
Norihisa Taira, Yushi Katsuyama, Masato Yoshioka, Yuri Okano, Hitoshi Masaki
BACKGROUND: Ascorbic acid (AsA) has multifunctional benefits on skin beauty, such as the reduction in oxidative stress and the induction of collagen production. Among them, the prevention and improvement of skin pigmentation by AsA is a most important benefit for people. However, it is well known that AsA not only is quite unstable in formulations but it also has a low capability of skin penetration due to its hydrophilic property. In addition, existing water-soluble AsA derivatives that were developed to improve its stability also have low skin penetration...
November 7, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29104457/the-extracts-of-astragalus-membranaceus-inhibit-melanogenesis-through-the-erk-signaling-pathway
#18
Yu-Tzu Tsao, Chun-Yu Kuo, Yu-Diao Kuan, Han-Chen Lin, Li-Hsien Wu, Che-Hsin Lee
Melanin is a normal production protecting skin from environment-causing damage. Plants produce some agents in response to their environment. These agents could be applied in cosmetic production. Some Chinese herbals have immunomodulatory activities and modulate the symptoms of several diseases. Melanogenesis represents a complex group of conditions that are thought to be mediated through a complex network of regulatory processes. Previously, some studies found that the extracts of Astragalus membranaceus (PG2) regulated immunity and supported hematopoiesis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29090638/indomethacin-inhibits-melanogenesis-via-down-regulation-of-mitf-mrna-transcription
#19
Kazuomi Sato, Masahiro Takei, Ray Iyota, Yoshimasa Muraoka, Marika Nagashima, Yoshitaka Yoshimura
Non-steroidal anti-inflammatory drugs (NSAIDs) exhibit several divergent biological effects. In this study, we investigated the effect of indomethacin on melanin synthesis using B16F1 melanoma cells. Indomethacin inhibited α-melanocyte stimulating hormone (α-MSH)-enhanced melanin synthesis in a dose-dependent manner. Western blotting analysis revealed that indomethacin significantly suppressed tyrosinase and Mitf protein levels. In a luciferase reporter assay, we found that indomethacin reduced tyrosinase promoter activity...
November 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29089976/odorants-could-elicit-repair-processes-in-melanized-neuronal-and-skin-cells
#20
REVIEW
Barbara Pavan, Alessandro Dalpiaz
The expression of ectopic olfactory receptors (ORs) in melanized cells, such as the human brain nigrostriatal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin melanogenesis, whereas OR expression in the dopaminergic neurons, characterized by accumulation of pigment neuromelanin, is downregulated in Parkinson's disease. Furthermore, the correlation between the pigmentation process and the dopamine pathway through α-synuclein expression is also highlighted. Purposely, these ORs are suggested as therapeutic target for neurodegenerative diseases related to the pigmentation disorders...
September 2017: Neural Regeneration Research
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