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https://www.readbyqxmd.com/read/29442220/methylquercetins-stimulate-melanin-biosynthesis-in-a-three-dimensional-skin-model
#1
Kosei Yamauchi, Tohru Mitsunaga
In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF). In contrast, 3MQ increased the activity of melanogenic enzymes without the involvement of MITF, which suggests that 3MQ inhibits the degradation of melanogenic enzymes. In the present study, we investigated the effects of 3MQ and 34'7TMQ on melanogenesis in normal human melanocytes and using a commercial three-dimensional (3D) skin model system...
February 13, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29442053/prochlorperazine-interaction-with-melanin-and-melanocytes
#2
M Otre Ba, D Wrześniok, J Rok, A Beberok, E Buszman
Prochlorperazine is a phenothiazine-class antipsychotic drug usually used to treat nausea, vomiting and schizophrenia. Phenothiazine derivatives have been known to cause serious side effects, like extrapyramidal symptoms, but also skin disorders which mechanism has not been fully established. The aim of this study was to examine the interaction between prochlorperazine and melanin as well as to estimate the effect of prochlorperazine on cell viability, melanogenesis and antioxidant defense system in normal human melanocytes...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29436631/trp%C3%A2-2-mediates-coat-color-pigmentation-in-sheep-skin
#3
Linli Xue, Yanan Li, Bingling Zhao, Tianzhi Chen, Yanjun Dong, Ruiwen Fan, Jingwei Li, Haidong Wang, Xiaoyan He
Tyrosinase‑related protein 2 (TRP‑2) is one of the most important members of the tyrosinase family, and is a key enzyme involved in melanin biosynthesis. In the present study, a skin transcriptome profile, immunohistochemistry, western blotting and reverse transcription‑quantitative polymerase chain reaction were used to investigate TRP‑2 expression in sheep with different coat colors, namely, black, white and black‑white. TRP‑2 was overexpressed in melanocytes in order to study the effect of TRP‑2 on melanin production...
February 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29430989/nk1r-5-ht1ar-interaction-is-related-to-the-regulation-of-melanogenesis
#4
Huali Wu, Yucheng Zhao, Qiaoling Huang, Minxuan Cai, Qi Pan, Mengsi Fu, Xiaohong An, Zhenjiang Xia, Meng Liu, Yu Jin, Ling He, Jing Shang
Substance P (SP) is a candidate mediator along the brain-skin axis and can mimic the effects of stress to regulate melanogenesis. Previously, we and others have found that the regulation of SP for pigmentary function was mediated by neurokinin 1 receptor (NK1R). Emerging evidence has accumulated that psychologic stress can induce dysfunction in the cutaneous serotonin 5-hydroxytryptamine (5-HT)-5-HT1A/1B receptor system, thereby resulting in skin hypopigmentation. Moreover, NK1R and 5-HTR (except 5-HT3) belong to GPCR...
February 7, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29427586/inhibition-of-human-tyrosinase-requires-molecular-motifs-distinctively-different-from-mushroom-tyrosinase
#5
Tobias Mann, Wolfram Gerwat, Jan Batzer, Kerstin Eggers, Cathrin Scherner, Horst Wenck, Franz Stäb, Vincent J Hearing, Klaus-Heinrich Röhm, Ludger Kolbe
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target to inhibit hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were identified using mushroom tyrosinase as the target. Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibitory concentration (IC50) in the millimolar range, while kojic acid showed a weak efficacy (IC50 > 400 μM)...
February 7, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29419941/toward-the-full-spectrum-of-genes-for-human-skin-colour
#6
Richard A Sturm, David L Duffy
Humans across the globe shows a remarkable diversity in colouration of skin, hair and eyes (Jablonski & Chaplin, 2017) reflecting adaption of pigmentation genes within populations to their environment (Sturm & Duffy, 2012), as well as other evolutionary forces. Skin colour is highly correlated with incident levels of solar UV, and this has led to hypotheses that the need for vitamin D synthesis and protection from photolysis of folate are major balancing selective pressures modulating melanogenesis in the epidermis necessary for both healthy bones at high Northern latitudes experiencing low solar irradiance, but also shielding the skin from the high equatorial sun exposure...
February 8, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29406397/isolation-and-characterization-of-circulating-melanoma-cells-by-size-filtration-and-fluorescent-in-situ-hybridization
#7
Masahiko Yanagita, Jason J Luke, Frank S Hodi, Pasi A Jänne, Cloud P Paweletz
Isolation of circulating tumor cells (CTCs) from blood of melanoma patients has been difficult owing to inconsistent expression of surface antigens. Here we report on the isolation, detection, and characterization of CTCs from blood of melanoma patients using microfiltration and fluorescent in-situ hybridization (FISH). Two tubes of blood from 15 patients with advanced melanoma were collected. These two tubes subsequently underwent filtration through a membrane with pore sizes of 7.5 μm. Isolated cells from one tube were analyzed by FISH for RREB1 (6p24), MYB (6q32), SE6 (D6Z1), and CCND1 (11q13) and the other paired specimen was analyzed by immunofluorescence for HMB45, melanoma-associated antigen recognized by T cells-1, tyrosinase and melanogenesis associated transcription factor...
February 5, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29404955/comparative-study-of-glyceryl-behenate-or-polyoxyethylene-40-stearate-based-lipid-carriers-for-trans-resveratrol-delivery-development-characterization-and-evaluation-of-the-in-vitro-tyrosinase-inhibition
#8
Naiara Fachinetti, Roberta Balansin Rigon, Josimar O Eloy, Mariana Rillo Sato, Karen Cristina Dos Santos, Marlus Chorilli
Trans-resveratrol (RSV) is a natural compound with several properties, such as the ability to inhibit the tyrosinase enzyme, with potential application as a skin-lightning agent and for the treatment of skin disorders associated with hyperpigmentation and melanogenesis. However, the drug faces several drawbacks which altogether limit its therapeutic application. Thus, drug loading into nanocarriers emerge as an alternative to circumvent these problems. Herein, nanostructured lipid carriers (NLCs) have been employed for RSV encapsulation, with comparison of two different lipids, glyceryl behenate (more hydrophobic), and polyoxyethylene 40 (PEG 40) stearate...
February 5, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29399291/sageretia-thea-fruit-extracts-rich-in-methyl-linoleate-and-methyl-linolenate-downregulate-melanogenesis-via-the-akt-gsk3%C3%AE-signaling-pathway
#9
Gyeong-A Ko, Sabina Shrestha, Somi Kim Cho
BACKGROUND/OBJECTIVES: Sageretia thea is traditionally used as a medicinal herb to treat various diseases, including skin disorders, in China and Korea. This study evaluated the inhibitory effect of Sageretia thea fruit on melanogenesis and its underlying mechanisms in B16F10 mouse melanoma cells. The active chemical compounds in anti-melanogenesis were determined in Sageretia thea. MATERIALS/METHODS: Solvent fractions from the crude extract were investigated for anti-melanogenic activities...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29397551/finasteride-inhibits-melanogenesis-through-regulation-of-the-adenylate-cyclase-in-melanocytes-and-melanoma-cells
#10
Jae Ok Seo, Silvia Yumnam, Kwang Won Jeong, Sun Yeou Kim
Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2...
February 3, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29393486/a-10%C3%A2-microrna-prognosis-scoring-system-in-esophageal-squamous-cell-carcinoma-constructed-using-bioinformatic-methods
#11
Qingchao Sun, Liang Zong, Haiping Zhang, Yanchao Deng, Changming Zhang, Liwei Zhang
MicroRNA (miR) signatures may aid the diagnosis and prediction of cancer; therefore, miRs associated with the prognosis of esophageal squamous cell carcinoma (ESCC) were screened. miR‑sequencing (seq) and mRNA‑seq data from early‑stage ESCC samples were downloaded from The Cancer Genome Atlas (TCGA) database, and samples from subjects with a >6‑month survival time were assessed with Cox regression analysis for prognosis‑associated miRs. A further two miR expression datasets of ESCC samples, GSE43732 and GSE13937, were downloaded from the Gene Expression Omnibus database...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29384219/pirna-19128-regulates-spermatogenesis-by-silencing-of-kit-in-chicken
#12
Qixin Guo, Lu Xu, Yulin Bi, Lingling Qiu, Yin Chen, Lingling Kong, Rui Pan, Guobin Chang
Spermatogenesis is a complex process. Some studies have shown that Piwi-interacting RNAs (piRNAs) play an important role in spermatogenesis. To verify the evaluate between piRNAs and PIWI proteins in chicken and its possible role in spermatogenesis and reproductive stem cell proliferation and differentiation, we performed immunoprecipitation and deep sequencing analyses and determined the expression profiles of small RNAs in primordial germ cells (PGCs), spermatogonial stem cells (SSCs), spermatogonia (Sa) cells and spermatozoa...
January 31, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29382138/isolation-and-quantification-of-ginsenoside-rh23-a-new-anti-melanogenic-compound-from-the-leaves-of-panax-ginseng
#13
Dae Young Lee, Hyoung-Geun Kim, Yeong-Geun Lee, Jin Hee Kim, Jae Won Lee, Bo-Ram Choi, In-Bae Jang, Geum-Soog Kim, Nam-In Baek
A new ginsenoside, named ginsenoside Rh23 (1), and 20-O-β-d-glucopyranosyl-3β,6α,12β,20β,25-pentahydroxydammar-23-ene (2) were isolated from the leaves of hydroponic Panax ginseng. Compounds were isolated by various column chromatography and their structures were determined based on spectroscopic methods, including high resolution quadrupole/time of flight mass spectrometry (HR-QTOF/MS), nuclear magnetic resonance (NMR) spectroscopy, and infrared (IR) spectroscopy. To determine anti-melanogenic activity, the change in the melanin content in melan-a cells treated with identified compounds was tested...
January 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29362867/the-stem-cell-factor-stimulated-melanogenesis-in-human-melanocytes-can-be-abrogated-by-interrupting-the-phosphorylation-of-msk1-evidence-for-involvement-of-the-p38-msk1-creb-mitf-axis
#14
Takao Niwano, Shuko Terazawa, Hiroaki Nakajima, Genji Imokawa
We recently found that treatment of normal human melanocytes (NHMs) with the antioxidant astaxanthin (AX) suppresses the stem cell factor (SCF)-stimulated protein expression levels of microphthalmia-associated transcription factor (MITF) at 1.5 h and of tyrosinase and endothelin B receptor at 96 h post-treatment. Analysis of the signaling cascade(s) involved revealed that although the major SCF-activated signaling cascade that leads to CREB activation (the c-KIT/Shc/Raf-1/ERK/RSK/CREB axis) is not interrupted, the increased phosphorylation of CREB is significantly abrogated by AX...
January 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29355275/effects-of-volatile-oil-from-ginger-on-the-murine-b16-melanoma-cells-and-its-mechanism
#15
Li-Xia Wang, Jia Qian, Li-Nan Zhao, Shao-Hua Zhao
In this study, the inhibitory effects of volatile oil from ginger on melanogenesis and its antioxidant characteristics were investigated. The effects of volatile oil from ginger on cell proliferation, melanin content and tyrosinase activity were determined using a microplate reader. In addition, the expression of melanogenesis-related protein was determined by western blotting. The results indicate that the tested concentrates of volatile oil from ginger showed inhibitory effects on cell proliferation and melanogenesis...
January 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29348721/rare-ginsenoside-ia-synthesized-from-f1-by-cloning-and-overexpression-of-the-udp-glycosyltransferase-gene-from-bacillus%C3%A2-subtilis-synthesis-characterization-and-in%C3%A2-vitro-melanogenesis%C3%A2-inhibition-activity-in-bl6b16-cells
#16
Dan-Dan Wang, Yan Jin, Chao Wang, Yeon-Ju Kim, Zuly Elizabeth Jimenez Perez, Nam In Baek, Ramya Mathiyalagan, Josua Markus, Deok-Chun Yang
Background: Ginsenoside F1 has been described to possess skin-whitening effects on humans. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using recombinant glycosyltransferase enzyme. Glycosylation has the advantage of synthesizing rare chemical compounds from common compounds with great ease. Methods: UDP-glycosyltransferase (BSGT1) gene from Bacillus subtilis was selected for cloning...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29337284/method-for-identification-of-sensitive-nodes-in-boolean-models-of-biological-networks
#17
Pooja A Dnyane, Shraddha S Puntambekar, Chetan J Gadgil
Biological systems are often represented as Boolean networks and analysed to identify sensitive nodes which on perturbation disproportionately change a predefined output. There exist different kinds of perturbation methods: perturbation of function, perturbation of state and perturbation in update scheme. Nodes may have defects in interpretation of the inputs from other nodes and calculation of the node output. To simulate these defects and systematically assess their effect on the system output, two new function perturbations, referred to as 'not of function' and 'function of not', are introduced...
February 2018: IET Systems Biology
https://www.readbyqxmd.com/read/29332193/melanogenesis-inhibitory-activity-of-components-from-salam-leaf-syzygium-polyanthum-extract
#18
Andriyana Setyawati, Kae Hirabayashi, Kosei Yamauchi, Hiroyuki Hattori, Tohru Mitsunaga, Irmanida Batubara, Rudi Heryanto, Hiroshi Hashimoto, Mitsuyuki Hotta
In order to identify a novel whitening agent, the methanol extract of S. polyanthum leaf was focused on by the screening test using nine Indonesian medicinal plants for the inhibition of melanogenesis and tyrosinase activity in B16 melanoma cells. Three novel compounds [(1) 1-(2,3,5-trihydroxy-4-methylphenyl)hexane-1-one, (2) 1-(2,3,5-trihydroxy methylphenyl)octane-1-one, and (3) (4E)-1-(2,3,5-trihydroxy-4-methylphenyl)decan-1-one and one known compound [(4) 1-(2,3,5-trihydroxy-4-methylphenyl)decan-1-one were isolated from the methanol extract...
January 13, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329871/isolation-of-proanthocyanidins-from-red-wine-and-their-inhibitory-effects-on-melanin-synthesis-in-vitro
#19
Takahiro Fujimaki, Shoko Mori, Manabu Horikawa, Yuko Fukui
The red wines made from Vitis vinifera were identified as skin-whitening effectors by using in vitro assays. OPCs in the wine were evaluated for tyrosinase activity and melanogenesis. Strong tyrosinase inhibitory activity was observed in fractions with high oligomeric proanthocyanidin (OPC) content. Among OPC dimers, a strong inhibitory effect on tyrosinase was observed with OPCs which contain (+)-catechin as an upper unit. Melanogenesis inhibitory effect was observed with OPCs which have (-)-epicatechin as upper units...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29328028/-skin-pathology-in-diabetes-mellitus-clinical-and-pathophysiological-correlations-review
#20
K Kochet, I Lytus, I Svistunov, O Sulaieva
Skin pathology is registered in vast majority of patients with diabetes mellitus (DM). Despite the abundance of publications on dermatological problems in DM, there is still a number of gaps to be discussed in terms of pathophysiological mechanisms. The goal of this review was to assess the mechanisms of development of different skin pathologies under DM. One of the key pathogenic mechanisms of skin lesions in diabetes is hyperglycemia and the effects of the advanced glycation end products, inducing oxidative stress, endothelial dysfunction and inflammation; that in its turn can accelerate the mechanisms of skin aging, the development of diabetic dermopathy and scleredema diabeticorum...
December 2017: Georgian Medical News
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