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Discontinuation of Anti-TNFa

E Andreadou, E Kemanetzoglou, Ch Brokalaki, M E Evangelopoulos, C Kilidireas, A Rombos, E Stamboulis
Tumor necrosis factor antagonists (anti-TNFa) are an established therapeutic option for several autoimmune and inflammatory bowel diseases. Despite their clinical effectiveness, neurological adverse events have been reported and literature data suggest a potential role of anti-TNFa in the induction of demyelination of the CNS. We present four patients treated with anti-TNFa who developed symptoms suggestive of CNS demyelination. The first patient, a 17-year-old male who received etanercept for psoriatic arthritis for eight months, presented with dysesthesias up to T4 level...
2013: Case Reports in Neurological Medicine
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