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https://www.readbyqxmd.com/read/29236333/effect-and-mechanism-of-lncrna-hotair-on-occurrence-and-development-of-gastric-cancer
#1
Xuan Feng, Suiping Huang
OBJECTIVE: In this study, we aimed at looking for the lncRNA abnormally expressed in gastric cancer (GC) tissues, and analyzing the association of its expression level with the clinicopathological feature and patient prognosis. The biological function of this lncRNA in occurrence and development of GC was studied in vivo and in vitro. The underlying molecular mechanism was further discussed. METHODS: We investigated the lncRNA expression level in GC tissues and normal gastric mucosa tissues by lncRNA chips analysis...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236028/beyond-disaster-preparedness-building-a-resilience-oriented-workforce-for-the-future
#2
REVIEW
Jaime Madrigano, Anita Chandra, Tracy Costigan, Joie D Acosta
Enhancing citizens' and communities' resilience is critical to adapt successfully to ongoing challenges faced by communities, as well as acute shocks resulting from disasters. While significant progress has been made in this area, several research and practice gaps remain. A crucial next step to advance resilience is the development of a resilience-oriented workforce. This narrative review examines existing literature to determine key components of a resilience-oriented workforce, with a focus on organizational structures, training and education, and leadership models...
December 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#3
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29235922/dna-methylation-reprogramming-of-human-cancer-cells-by-expression-of-a-plant-5-methylcytosine-dna-glycosylase
#4
Teresa Morales-Ruiz, María Victoria García-Ortiz, Iván Devesa-Guerra, Laura Raya-Ruiz, Juan R Tejedor, Gustavo F Bayón, Marta I Sierra, Mario F Fraga, Rafael R Ariza, Teresa Roldán-Arjona
Patterns of DNA methylation, an important epigenetic modification involved in gene silencing and development, are disrupted in cancer cells. Understanding the functional significance of aberrant methylation in tumors remains challenging, due in part to the lack of suitable tools to actively modify methylation patterns. DNA demethylation caused by mammalian DNA methyltransferase inhibitors is transient and replication-dependent, whereas that induced by TET enzymes involves oxidized 5mC derivatives that perform poorly understood regulatory functions...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29235851/semi-interpenetrating-polymer-network-composite-gel-electrolytes-employing-vinyl-functionalized-silica-for-lithium-oxygen-batteries-with-enhanced-cycling-stability
#5
Hyun-Sik Woo, Yong-Bok Moon, Samuel Seo, Ho-Taek Lee, Dong-Won Kim
A major challenge of lithium-oxygen batteries is to develop a stable electrolyte not only to suppress solvent evaporation and lithium dendrite growth, but also to resist against the attack by superoxide anion radical formed at the positive electrode. The present study demonstrates the enhancement of cycling stability by addressing the above challenges through the use of three-dimensional semi-interpenetrating polymer network (semi-IPN) composite gel polymer electrolyte when fabricating the lithium-oxygen cell...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235444/contact-guidance-for-cardiac-tissue-engineering-using-3d-bioprinted-gelatin-patterned-hydrogel
#6
Ajay Tijore, Scott Alexander Irvine, Udi Sarig, Priyadarshini Mhaisalkar, Vrushali Baisane, Subbu S Venkatraman
Here, we have developed a 3D bioprinted microchanneled gelatin hydrogel that promotes human mesenchymal stem cell (hMSC) myocardial commitment and supports native cardiomyocytes (CMs) contractile functionality. Firstly, we studied the effect of bioprinted microchanneled hydrogel on the alignment, elongation, and differentiation of hMSC. Notably, the cells displayed well defined F-actin anisotropy and elongated morphology on the microchanneled hydrogel, hence showing the effects of topographical control over cell behavior...
December 13, 2017: Biofabrication
https://www.readbyqxmd.com/read/29235402/biofilm-related-disease
#7
Jose Luis Del Pozo
Biofilm formation represents a protected mode of growth that renders bacterial cells less susceptible to antimicrobials and to killing by host immune effector mechanisms and so enables the pathogens to survive in hostile environments and also to disperse and colonize new niches. Biofilm disease includes device-related infections, chronic infections in the absence of a foreign body, and even malfunction of medical devices. Areas covered: This review puts forward a new medical entity that represents a major public health issue, which we have named "biofilm-related disease"...
December 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29235374/computational-modeling-in-glioblastoma-from-the-prediction-of-blood-brain-barrier-permeability-to-the-simulation-of-tumor-behavior
#8
Ana Miranda, Tânia Cova, João Sousa, Carla Vitorino, Alberto Pais
The integrated in silico-in vitro-in vivo approaches have fostered the development of new treatment strategies for glioblastoma patients and improved diagnosis, establishing the bridge between biochemical research and clinical practice. These approaches have provided new insights on the identification of bioactive compounds and on the complex mechanisms underlying the interactions among glioblastoma cells, and the tumor microenvironment. This review focuses on the key advances pertaining to computational modeling in glioblastoma, including predictive data on drug permeability across the blood-brain barrier, tumor growth and treatment responses...
December 13, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29235354/ultra-low-carbon-nanotube-toughened-epoxy-the-critical-role-of-a-double-layer-interface
#9
Jingwei Liu, Chao Chen, Yuezhan Feng, Yonggui Liao, Yun-Sheng Ye, Xiaolin Xie, Yiu-Wing Mai
Understanding the chemistry and structure of interfaces within epoxy resins is important for studying the mechanical properties of nanofiller-filled nanocomposites as well as for developing high performance polymer nanocomposites. Despite intensive efforts to construct nanofillers/matrix interfaces, few studies have demonstrated both an enhanced stress transferring efficiency while avoiding unfavorable defor-mation, due to undesirable interface fractures. Here, we report an optimized method to prepare epoxy-based nanocomposites whose interfaces are chemically modulated by poly(glycidyl methacrylate)-block-poly(hexyl methacrylate) (PGMA-b-PHMA) functionalized multi-walled carbon nanotubes (bc@fMWNT) and also offer a fundamental explanation of crack growth behavior and the toughening mechanism of the resulting nanocomposites...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235171/india-s-integrated-child-development-services-scheme-challenges-for-scaling-up
#10
N Rao, V Kaul
BACKGROUND: India had around 158 million children under the age of 6 and about 26 million births in 2015. In the same year, India's Integrated Child Development Services Scheme served about 82 million children under 6 years and over 19 million pregnant women and lactating mothers. These 102 million beneficiaries received services in about 1.3 million centres. METHOD: This paper reviews the growth of the Scheme and considers challenges to scaling up quality with equity based on results of large-scale national or multistate studies...
January 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29235167/care-for-child-development-an-intervention-in-support-of-responsive-caregiving-and-early-child-development
#11
J E Lucas, L M Richter, B Daelmans
BACKGROUND: An estimated 43% of children younger than 5 years of age are at elevated risk of failing to achieve their human potential. In response, the World Health Organization and UNICEF developed Care for Child Development (CCD), based on the science of child development, to improve sensitive and responsive caregiving and promote the psychosocial development of young children. METHODS: In 2015, the World Health Organization and UNICEF identified sites where CCD has been implemented and sustained...
January 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29235130/melt-electrospun-bilayered-scaffolds-for-tissue-integration-of-a-suture-less-inflow-cannula-for-rotary-blood-pumps
#12
Sam Liao, Christina Theodoropoulos, Keith A Blackwood, Maria A Woodruff, Shaun D Gregory
Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis of the myocardium. To circumvent this issue, a bilayered scaffold has been developed to promote tissue growth at the interface between cannula and myocardium. The bilayered scaffold consists of a silicone base layer, which mimics the seal, and a melt electrospun polycaprolactone scaffold to serve as a tissue integration layer...
December 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29235057/design-and-assessment-of-a-dynamic-perfusion-bioreactor-for-large-bone-tissue-engineering-scaffolds
#13
Birru Bhaskar, Robert Owen, Hossein Bahmaee, Parcha Sreenivasa Rao, Gwendolen C Reilly
Bioreactors can be used to apply fluid flow in vitro to scaffolds to improve mass transport of media and apply mechanical forces to cells. In this study, we developed and tested an autoclavable, modular perfusion bioreactor suitable for large scaffolds. We investigated the effects of fluid flow induced shear stress (FFSS) on osteogenic differentiation of human embryonic stem cell-derived mesenchymal progenitors (hES-MP cells) cultured on large polyurethane (PU) scaffolds (30 mm diameter × 5 mm thickness) in osteogenesis induction media (OIM)...
December 12, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29235018/inverse-correlation-between-maternal-plasma-asymmetric-dimethylarginine-adma-and-birthweight-percentile-in-women-with-impaired-placental-perfusion-circulating-adma-as-an-no-independent-indicator-of-fetal-growth-restriction
#14
Dimitrios Tsikas, Alexander Bollenbach, Makrina D Savvidou
L-Arginine (Arg) is the enzymatic precursor of nitric oxide (NO) which has multiple biological functions. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of NO. We hypothesized that the ADMA and SDMA have additional biological functions in pregnancy, beyond NO synthesis, and may play a role in the regulation of birthweight (BW). To investigate this issue, we measured the plasma concentration of ADMA, SDMA, Arg and the NO metabolites nitrite and nitrate, at 23-25 weeks of gestation in women with normal placental function (Group 1) and in women with impaired placental perfusion; 19 of these women had normal outcome (Group 2), 14 had a fetus that was growth restricted (Group 3), and 10 women eventually developed preeclampsia (Group 4)...
December 12, 2017: Amino Acids
https://www.readbyqxmd.com/read/29234982/a-multicellular-model-of-intestinal-crypt-buckling-and-fission
#15
Axel A Almet, Barry D Hughes, Kerry A Landman, Inke S Näthke, James M Osborne
Crypt fission is an in vivo tissue deformation process that is involved in both intestinal homeostasis and colorectal tumourigenesis. Despite its importance, the mechanics underlying crypt fission are currently poorly understood. Recent experimental development of organoids, organ-like buds cultured from crypt stem cells in vitro, has shown promise in shedding light on crypt fission. Drawing inspiration from observations of organoid growth and fission in vivo, we develop a computational model of a deformable epithelial tissue layer...
December 12, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29234895/intestinal-stem-cells-to-advance-drug-development-precision-and-regenerative-medicine-a-paradigm-shift-in-translational-research
#16
Jonathan P Mochel, Albert E Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G Martín, Karin Allenspach
Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and metabolism. They are, therefore, particularly relevant to study the gastrointestinal (GI) absorption of oral medications. In addition, organoids have the potential to serve as a robust preclinical model for demonstrating the effectiveness of new drugs more rapidly, with more certainty, and at lower costs compared with live animal studies...
December 12, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29234727/the-dual-role-of-bone-morphogenetic-proteins-in-cancer
#17
REVIEW
Duc-Hiep Bach, Hyen Joo Park, Sang Kook Lee
Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth factor proteins that belong to the transforming growth factor-β (TGF-β) family and are highly associated with bone formation and disease development. Aberrant expression of various BMPs has been reported in several cancer tissues. Biological function studies have elicited the dual role of BMPs in both cancer development and suppression. Furthermore, a variety of BMP antagonists, ligands, and receptors have been shown to reduce or enhance tumorigenesis and metastasis...
March 30, 2018: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/29234596/exploring-the-multiple-hit-hypothesis-of-preterm-white-matter-damage-using-diffusion-mri
#18
Madeleine L Barnett, Nora Tusor, Gareth Ball, Andrew Chew, Shona Falconer, Paul Aljabar, Jessica A Kimpton, Nigel Kennea, Mary Rutherford, A David Edwards, Serena J Counsell
Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk factors. Our aim was to test this hypothesis in a large cohort of preterm infants using diffusion weighted magnetic resonance imaging (dMRI). Methods: We studied 491 infants (52% male) without focal destructive brain lesions born at < 34 weeks, who underwent structural and dMRI at a specialist Neonatal Imaging Centre...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29234490/geminin-deficiency-enhances-survival-in-a-murine-medulloblastoma-model-by-inducing-apoptosis-of-preneoplastic-granule-neuron-precursors
#19
Savita Sankar, Ethan Patterson, Emily M Lewis, Laura E Waller, Caili Tong, Joshua Dearborn, David Wozniak, Joshua B Rubin, Kristen L Kroll
Medulloblastoma is the most common malignant brain cancer of childhood. Further understanding of tumorigenic mechanisms may define new therapeutic targets. Geminin maintains genome fidelity by controlling re-initiation of DNA replication within a cell cycle. In some contexts, Geminin inhibition induces cancer-selective cell cycle arrest and apoptosis and/or sensitizes cancer cells to Topoisomerase IIα inhibitors such as etoposide, which is used in combination chemotherapies for medulloblastoma. However, Geminin's potential role in medulloblastoma tumorigenesis remained undefined...
September 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29234488/sirt6-histone-deacetylase-functions-as-a-potential-oncogene-in-human-melanoma
#20
Liz Mariely Garcia-Peterson, Mary Ann Ndiaye, Chandra K Singh, Gagan Chhabra, Wei Huang, Nihal Ahmad
Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not diagnosed early. Despite recent therapeutic advances, management of melanoma remains difficult. Therefore, novel molecular targets and strategies are required to manage this neoplasm. This study was undertaken to determine the role of the sirtuin SIRT6 in melanoma. Employing a panel of human melanoma cells and normal human melanocytes, we found significant SIRT6 mRNA and protein upregulation in melanoma cells. Further, using a tissue microarray coupled with quantitative Vectra analysis, we demonstrated significant SIRT6 overexpression in human melanoma tissues...
September 2017: Genes & Cancer
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