keyword
https://read.qxmd.com/read/38537200/combining-modelling-and-experimental-approaches-to-assess-the-feasibility-of-developing-rice-oil-palm-agroforestry-system
#1
JOURNAL ARTICLE
Raphaël P A Perez, Rémi Vezy, Romain Bordon, Thomas Laisné, Sandrine Roques, Maria-Camila Rebolledo, Lauriane Rouan, Denis Fabre, Olivier Gibert, Marcel De Raissac
Monoculture systems in SouthEast Asia are facing challenges due to climate change-induced extreme weather conditions, leading to significant annual production losses for rice and oil palm. To ensure the stability of these crops, innovative strategies like resilient agroforestry systems need to be explored. Converting oil palm monocultures to rice-based intercropping systems shows promise, but achieving optimal yields requires adjusting palm density and identifying rice varieties adapted to changes in light quantity and diurnal fluctuation...
March 27, 2024: Journal of Experimental Botany
https://read.qxmd.com/read/38537140/first-report-of-soybean-root-rot-caused-by-fusarium-proliferatum-in-the-republic-of-korea
#2
JOURNAL ARTICLE
In-Jeong Kang, Mirang Lee, Sang Yun Han, Yul-Ho Kim, Sungwoo Lee
Fusarium species are widespread soilborne pathogens that can cause damping-off, root rot, and wilting in soybean [ Glycine max (L.) Merrill], subsequently leading to significant yield suppression. Several Fusarium spp. have already been documented for their pathogenicity on soybean plants in the Republic of Korea. The nationwide monitoring of soybean diseases continues to identify new pathogenic Fusarium spp. In 2016, five plant samples at R3-R4 growth stages, showing symptoms of wilting in the upper parts and root rot, were collected in Suwon, Gyeonggi, Republic of Korea...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537135/first-report-of-white-mucus-disease-caused-by-fuligo-gyrosa-on-agrocybe-chaxingu-in-china
#3
JOURNAL ARTICLE
Xutao Chen, Qing Liu, Guoliang Meng, Xinhong Peng, Caihong Dong, Yunhui Wei, Guanghua Huo
Agrocybe chaxingu is an edible and medicinal mushroom widely cultivated in China (Liu et al. 2021). Agrocybe chaxingu is extremely well-liked for the unique flavor and nutritional value. In May 2021, a serious white mucus disease was observed in the farms of A. chaxingu in the Ganxian district of Ganzhou City, Jiangxi Province, China, with an approximate disease incidence of 20%. In the years of 2022 and 2023, the same white mucus disease on A. chaxingu was observed in the farms in Nanchang City, Jiujiang City and Guangchang County, Jiangxi Province, China...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38536956/integrated-in-situ-fabrication-of-cuo-nanorod-decorated-polymer-membranes-for-the-catalytic-flow-through-reduction-of-p-nitrophenol
#4
JOURNAL ARTICLE
S Amir H Hesaraki, Oleg Prymak, Markus Heidelmann, Mathias Ulbricht, Lukas Fischer
We developed a novel method to fabricate copper nanorods in situ in a poly(ether sulfone) (15 wt %) casting solution by a sonochemical reduction of Cu2+ ions with NaBH4 . The main twist is the addition of ethanol to remove excess NaBH4 through Cu(0) catalyzed ethanolysis. This enabled the direct use of the resulting copper-containing casting dispersions for membrane preparation by liquid nonsolvent-induced phase separation and led to full utilization of the copper source, generating zero metal waste. We characterized the copper nanorods as presented in the membranes via scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and UV/vis spectroscopy...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38536935/the-gut-microbiota-posttranslationally-modifies-iga1-in-autoimmune-glomerulonephritis
#5
JOURNAL ARTICLE
Patrick J Gleeson, Nicolas Benech, Jonathan Chemouny, Eleftheria Metallinou, Laureline Berthelot, Jennifer da Silva, Julie Bex-Coudrat, Erwan Boedec, Fanny Canesi, Carine Bounaix, Willy Morelle, Maryse Moya-Nilges, John Kenny, Liam O'Mahony, Loredana Saveanu, Bertrand Arnulf, Aurélie Sannier, Eric Daugas, François Vrtovsnik, Patricia Lepage, Harry Sokol, Renato C Monteiro
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that are deposited in the kidneys, leading to glomerulonephritis. In the intestinal microbiota of patients with IgA nephropathy, there was increased relative abundance of mucin-degrading bacteria, including Akkermansia muciniphila ...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536921/glutamine-antagonist-drp-104-suppresses-tumor-growth-and-enhances-response-to-checkpoint-blockade-in-keap1-mutant-lung-cancer
#6
JOURNAL ARTICLE
Ray Pillai, Sarah E LeBoeuf, Yuan Hao, Connie New, Jenna L E Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L Wu, Burcu Karadal-Ferrena, Alberto Herrera, Ellie Ivanova, Michael Cross, Jozef P Bossowski, Hongyu Ding, Makiko Hayashi, Sahith Rajalingam, Triantafyllia Karakousi, Volkan I Sayin, Kamal M Khanna, Kwok-Kin Wong, Robert Wild, Aristotelis Tsirigos, John T Poirier, Charles M Rudin, Shawn M Davidson, Sergei B Koralov, Thales Papagiannakopoulos
Loss-of-function mutations in KEAP1 frequently occur in lung cancer and are associated with poor prognosis and resistance to standard of care treatment, highlighting the need for the development of targeted therapies. We previously showed that KEAP1 mutant tumors consume glutamine to support the metabolic rewiring associated with NRF2-dependent antioxidant production. Here, using preclinical patient-derived xenograft models and antigenic orthotopic lung cancer models, we show that the glutamine antagonist prodrug DRP-104 impairs the growth of KEAP1 mutant tumors...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536914/egfr-targeting-phostacs-as-a-dual-inhibitory-approach-reveals-differential-downstream-signaling
#7
JOURNAL ARTICLE
Zhenyi Hu, Po-Han Chen, Wenxue Li, Mackenzie Krone, Sijin Zheng, Jacques Saarbach, Ines Urquizo Velasco, John Hines, Yansheng Liu, Craig M Crews
We recently developed a heterobifunctional approach [phosphorylation targeting chimeras (PhosTACs)] to achieve the targeted protein dephosphorylation (TPDephos). Here, we envisioned combining the inhibitory effects of receptor tyrosine kinase inhibitors (RTKIs) and the active dephosphorylation by phosphatases to achieve dual inhibition of kinases. We report an example of tyrosine phosphatase-based TPDephos and the effective epidermal growth factor receptor (EGFR) tyrosine dephosphorylation. We also used phosphoproteomic approaches to study the signaling transductions affected by PhosTAC-related molecules at the proteome-wide level...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#8
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536857/investigating-the-relationship-between-microbial-network-features-of-giant-kelp-seedbank-cultures-and-subsequent-farm-performance
#9
JOURNAL ARTICLE
Melisa G Osborne, Ariel Levi Simons, Gary Molano, Bernadeth Tolentino, Anupam Singh, Gabriel J Montecinos Arismendi, Filipe Alberto, Sergey V Nuzhdin
Microbial inoculants can increase the yield of cultivated crops and are successful in independent trials; however, efficacy drops in large-scale applications due to insufficient consideration of microbial community dynamics. The structure of microbiomes, in addition to the impact of individual taxa, is an important factor to consider when designing growth-promoting inoculants. Here, we investigate the microbial network and community assembly patterns of Macrocystis pyrifera gametophyte germplasm cultures (collectively referred to as a "seedbank") used to cultivate an offshore farm in Santa Barbara, California, and identify network features associated with increased biomass of mature sporophytes...
2024: PloS One
https://read.qxmd.com/read/38536821/the-use-of-kudoh-method-for-culture-of-mycobacterium-tuberculosis-and-mycobacterium-africanum-in-the-gambia
#10
JOURNAL ARTICLE
Tijan Jobarteh, Jacob Otu, Ensa Gitteh, Francis S Mendy, Tutty Isatou Faal-Jawara, Boatema Ofori-Anyinam, Binta Sarr, Abi Janet Riley, Abigail Ayorinde, Bouke C de Jong, Beate Kampmann, Ousman Secka, Florian Gehre
BACKGROUND: Mycobacterium tuberculosis culturing remains the gold standard for laboratory diagnosis of tuberculosis. Tuberculosis remains a great public health problem in developing countries like The Gambia, as most of the methods currently used for bacterial isolation are either time-consuming or costly. OBJECTIVE: To evaluate the Kudoh swab method in a West African setting in Gambia, with a particular focus on the method's performance when culturing Mycobacterium africanum West Africa 2 (MAF2) isolates...
2024: PloS One
https://read.qxmd.com/read/38536774/the-impact-of-climate-change-on-the-agriculture-and-the-economy-of-southern-gaul-new-perspectives-of-agent-based-modelling
#11
JOURNAL ARTICLE
Nicolas Bernigaud, Alberte Bondeau, Joël Guiot, Frédérique Bertoncello, Marie-Jeanne Ouriachi, Laurent Bouby, Philippe Leveau, Loup Bernard, Delphine Isoardi
What impact did the Roman Climate Optimum (RCO) and the Late Antique Little Ice Age (LALIA) have on the rise and fall of the Roman Empire? Our article presents an agent-based modelling (ABM) approach developed to evaluate the impact of climate change on the profitability of vineyards, olive groves, and grain farms in Southern Gaul, which were the main source of wealth in the roman period. This ABM simulates an agroecosystem model which processes potential agricultural yield values from paleoclimatic data. The model calculates the revenues made by agricultural exploitations from the sale of crops whose annual volumes vary according to climate and market prices...
2024: PloS One
https://read.qxmd.com/read/38536770/a-co-reactive-immunosensor-based-on-ti-3-c-2-t-x-mxene-tio-2-mos-2-hybrids-promoting-luminol-au-ni-co-ncs-electrochemiluminescence-for-cyfra-21-1-detection
#12
JOURNAL ARTICLE
Xiang Ren, Mingyue Shao, Zuoxun Xie, Xiaojian Li, Hongmin Ma, Dawei Fan, Jinxiu Zhao, Qin Wei
The construction of assays is capable of accurately detecting cytokeratin-19 (CYFRA 21-1), which is critical for the rapid diagnosis of nonsmall cell lung cancer. In this work, a novel electrochemiluminescence (ECL) immunosensor based on the co-reaction promotion of luminol@Au@Ni-Co nanocages (NCs) as ECL probe by Ti3 C2 T x MXene@TiO2 -MoS2 hybrids as co-reaction accelerator was proposed to detect CYFRA 21-1. Ni-Co NCs, as a derivative of Prussian blue analogs, can be loaded with large quantities of Au NPs, luminol, and CYFRA 21-1 secondary antibodies due to their high specific surface area...
March 27, 2024: ACS Sensors
https://read.qxmd.com/read/38536602/endoscopic-loco-regional-treatment-in-controlling-pancreatic-neuroendocrine-tumors-pnets-behavior-a-case-series-and-literature-review
#13
JOURNAL ARTICLE
Cosmas Rinaldi Adithya Lesmana
Pancreatic neuroendocrine tumors (PNETs) are considered rare pancreatic neoplasms, and it is a challenging disease entity due to its indolent behavior and is difficult to manage. Diagnostic challenge is usually found in the imaging-based approach, such as transabdominal ultrasound, abdominal CT scan, and abdominal MRI. Surgery is still the main key player in controlling the disease. The main problems in clinical practice are the early detection of small PNETs lesion and non-functional PNET (NF-PNET) cases. Most cases usually come with large tumor size or metastatic disease...
March 27, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#14
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38536235/decentralizing-health-care-history-and-opportunities-of-web3
#15
JOURNAL ARTICLE
Aditya Narayan, Kydo Weng, Nirav Shah
This paper explores the relationship between the development of the internet and health care, highlighting their parallel growth and mutual influence. It delves into the transition from the early, static days of Web 1.0, akin to siloed physician expertise in health care, to the more interactive and patient-centric era of Web 2.0, which was accompanied by advancements in medical technologies and patient engagement. This paper then focuses on the emerging era of Web3-the decentralized web-which promises a transformative shift in health care, particularly in how patient data are managed, accessed, and used...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536126/water-potential-from-adaptive-force-matching-for-ice-and-liquid-with-revised-dispersion-predicts-supercooled-liquid-anomalies-in-good-agreement-with-two-independent-experimental-fits
#16
JOURNAL ARTICLE
Raymond Weldon, Feng Wang
A revised version of the Water potential from Adaptive force matching for Ice and Liquid (WAIL) was developed by using the previous data set for fitting the WAIL model but with a dispersion term calculated using symmetry adapted perturbation theory (SAPT). The model has no adjustable parameters and relies solely on fitting first-principles information. The new model, named revised WAIL (rWAIL), shows improved predictions of most properties of water when compared to the previously published WAIL model. The rWAIL model also compares favorably to other first-principles-derived water models, such as MB-Pol, at only a fraction of the computational cost...
March 27, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#17
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38536089/cloning-and-functional-mechanism-of-the-dwarf-gene-gba-affecting-stem-elongation-and-cellulose-biosynthesis-in-jute-corchorus-olitorius
#18
JOURNAL ARTICLE
Qin Li, Siyuan Chen, Lu Chen, Lingling Zhuang, Huawei Wei, Shaolian Jiang, Chuanyu Wang, Jianmin Qi, Pingping Fang, Jiantang Xu, Aifen Tao, Liwu Zhang
Plant height (PH) is an important factor affecting bast fiber yield in jute. Here, we report the mechanism of dwarfism in the 'Guangbaai' (gba) of jute. The mutant gba had shorter internode length and cell length compared to the standard cultivar 'TaiZi 4' (TZ4). Exogenous GA3 treatment indicated that gba is a GA-insensitive dwarf mutant. Quantitative trait locus (QTL) analysis of three PH-related traits via a high-density genetic linkage map according to re-seq showed that a total of 25 QTLs were identified, including 13 QTLs for PH, with phenotypic variation explained ranging from 2...
March 27, 2024: Plant Journal
https://read.qxmd.com/read/38536039/the-nature-of-combat-stress-development-during-military-operations-and-psychotherapy-in-extreme-situations
#19
JOURNAL ARTICLE
Yanina Ovsyannikova, Diana Pokhilko, Mykola Krasnokutskyi, Valentyn Kerdyvar, Kateryna Kreshchuk
The purpose of the research work is the theoretical and empirical analysis of the study of the nature of combat stress in military personnel and the assessment of psychotherapeutic methods of providing psychological assistance in extreme situations. The authors used the following methods to achieve this goal: method of analysis and synthesis, hermeneutic method, testing method, comparative method, and generalization method. The results of the research work have revealed the meaning of traumatic stress, psychological trauma, and combat mental trauma, and explained the concept of combat stress and the dynamics of its growth...
March 13, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38536012/development-of-a-tannic-acid-and-silicate-ion-functionalized-pva-starch-composite-hydrogel-for-in-situ-skeletal-muscle-repairing
#20
JOURNAL ARTICLE
Longkang Li, Huipeng Li, Zhentian Diao, Huan Zhou, Yanjie Bai, Lei Yang
The repair capacity of skeletal muscle is severely diminished in massive skeletal muscle injuries accompanied by inflammation, resulting in muscle function loss and scar tissue formation. In the current work, we developed a tannic acid (TA)- and silicate ion-functionalized tissue adhesive poly(vinyl alcohol) (PVA)-starch composite hydrogel, referred to as PSTS (PVA-starch-TA-SiO3 2- ). It was formed based on the hydrogen bonding of TA to organic polymers, as well as silicate-TA ligand interaction. PSTS could be gelatinized in minutes at room temperature with crosslinked network formation, making it applicable for injection...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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