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https://www.readbyqxmd.com/read/29913346/beyond-the-photocycle-how-cryptochromes-regulate-photoresponses-in-plants
#1
REVIEW
Qin Wang, Zecheng Zuo, Xu Wang, Qing Liu, Lianfeng Gu, Yoshito Oka, Chentao Lin
Cryptochromes (CRYs) are blue light receptors that mediate light regulation of plant growth and development. Land plants possess various numbers of cryptochromes, CRY1 and CRY2, which serve overlapping and partially redundant functions in different plant species. Cryptochromes exist as physiologically inactive monomers in darkness; photoexcited cryptochromes undergo homodimerization to increase their affinity to the CRY-signaling proteins, such as CIBs (CRY2-interacting bHLH), PIFs (Phytochrome-Interacting Factors), AUX/IAA (Auxin/INDOLE-3-ACETIC ACID), and the COP1-SPAs (Constitutive Photomorphogenesis 1-Suppressors of Phytochrome A) complexes...
June 15, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29913272/sirna-lipopolymer-nanoparticles-to-arrest-growth-of-chronic-myeloid-leukemia-cells-in-vitro-and-in-vivo
#2
Juliana Valencia-Serna, Hamidreza M Aliabadi, Adam Manfrin, Mahsa Mohseni, Xiaoyan Jiang, Hasan Uludag
Therapies for the treatment of Chronic Myeloid Leukemia and other leukemias are still limited for patients at advanced stages, which allow development of point mutations in the BCR-ABL fusion gene that render CML cells insensitive to therapies. An effective non-viral delivery system based on lipopolymers is described in this study to deliver specific siRNAs to CML cells for therapeutic gene silencing. The lipopolymer, based on the lipid α-linolenic acid (αLA) substitution on low molecular weight polyethyleneimine (PEI), was used to deliver siRNA against the BCR-ABL gene and, the resultant therapeutic effect was evaluated in in vitro and in vivo CML models...
June 15, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29913255/chemoprevention-of-leishmaniasis-in-vitro-antiparasitic-activity-of-dibenzalacetone-a-synthetic-curcumin-analog-leads-to-apoptotic-cell-death-in-leishmania-donovani
#3
Indira Singh Chauhan, G SubbaRao, Jai Shankar, Lalit Kumar Singh Chauhan, Govind J Kapadia, Neeloo Singh
Curcumin is the major phenolic compound found in turmeric, a dry powder of rhizomes and roots of the plant, Curcuma longa L., which is widely used as spice and food colorant around the world, and in herbal medicinal practice in Asian countries. The present study reports the leishmanicidal activity of trans-dibenzalacetone (DBA), a synthetic monoketone analog of curcumin, against Leishmania donovani parasites. We for the first time report the antiproliferative effect of a curcumin analog (DBA) on the intracellular amastigotes of L...
June 15, 2018: Parasitology International
https://www.readbyqxmd.com/read/29913237/hsa-let-7b-inhibits-cell-proliferation-by-targeting-plk1-in-hcc
#4
Zili He, Wen Deng, Bo Jiang, Sulai Liu, Mingchun Tang, Yi Liu, Jian Zhang
Previous studies have shown that high levels of PLK1 are expressed in HCC, and PLK1 inhibitors are being tested in clinical trials. However, the mechanisms, which regulate PLK1 expression in HCC, have not been clarified. Here, we show that induction of let-7b over-expression inhibits the PLK1-regulated luciferase activity in HEK-293T cells, and decreases the levels of PLK1 expression in HCC cells. Furthermore, the levels of let-7b expression were negatively correlated with PLK1 expression in HCC tissues. Let-7b over-expression inhibited the proliferation of HCC cells and promoted their apoptosis, which were partially rescued by increased PLK1 expression...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29913155/antifibrotic-role-of-pgc-1%C3%AE-sirna-against-tgf-%C3%AE-1-induced-renal-interstitial-fibrosis
#5
Jue-Long Wang, Chin-Wang Chen, Mu-Rou Tsai, Shu-Fen Liu, Tsuing-Jeu Hung, Yu-Ju-Hung, Wen-Teng Chang, Ming-Der Shi, Pei-Fang Hsieh, Yu-Lin Yang
Peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1α) is a transcriptional coactivator that regulates energy metabolism and mitochondrial biogenesis. Recently, mitochondrial dysfunction has been indicated as an established risk factor for the development of renal fibrosis. However, whether PGC-1α is involved in the pathogenesis of renal fibrosis is unknown. In this study, we treated NRK-49F (normal rat kidney fibroblast) cells with transforming growth factor-beta 1 (TGF-β1) for 24h to establish an in vitro fibrosis model...
June 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29913153/pag1-promotes-the-inherent-radioresistance-of-laryngeal-cancer-cells-via-activation-of-stat3
#6
Li Shen, Qing Ke, Jingjing Chai, Chuanyi Zhang, Li Qiu, Feng Peng, Xinzhou Deng, Zhiguo Luo
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) is a ubiquitous protein that is essential for the development and progression of various malignancies. A previous study in our laboratory confirmed that PAG1 plays an important role in modulating the inherent radioresistance of laryngeal cancer cells, but the underlying mechanisms are still poorly defined. In this study, we found that PAG1 was significantly increased in laryngeal cancer tissues compared to adjacent non-tumor tissues (P < 0...
June 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29913021/implementation-of-a-clinical-prediction-model-using-daily-postnatal-weight-gain-birth-weight-and-gestational-age-to-risk-stratify-rop
#7
Kortany McCauley, Anupama Chundu, Helen Song, Robin High, Donny Suh
PURPOSE: To develop a simple prognostic model using postnatal weight gain, birth weight, and gestational age to identify infants at risk for developing severe retinopathy of prematurity (ROP). METHODS: Medical records from two tertiary referral centers with the diagnosis code "Retinopathy of Prematurity" were evaluated. Those with a birth weight of 1,500 g or less, gestational age of 30 weeks or younger, and unstable clinical courses were included. Multivariate regression analysis was applied to transform three independent variables into a growth rate algorithm...
June 18, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29912984/anti-replicative-recombinant-5s-rrna-molecules-can-modulate-the-mtdna-heteroplasmy-in-a-glucose-dependent-manner
#8
Romuald Loutre, Anne-Marie Heckel, Damien Jeandard, Ivan Tarassov, Nina Entelis
Mutations in mitochondrial DNA are an important source of severe and incurable human diseases. The vast majority of these mutations are heteroplasmic, meaning that mutant and wild-type genomes are present simultaneously in the same cell. Only a very high proportion of mutant mitochondrial DNA (heteroplasmy level) leads to pathological consequences. We previously demonstrated that mitochondrial targeting of small RNAs designed to anneal with mutant mtDNA can decrease the heteroplasmy level by specific inhibition of mutant mtDNA replication, thus representing a potential therapy...
2018: PloS One
https://www.readbyqxmd.com/read/29912979/evidence-of-cyclical-light-dark-regulated-expression-of-freezing-tolerance-in-young-winter-wheat-plants
#9
Daniel Z Skinner, Brian Bellinger, William Hiscox, Gregory L Helms
The ability of winter wheat (Triticum aestivum L.) plants to develop freezing tolerance through cold acclimation is a complex rait that responds to many environmental cues including day length and temperature. A large part of the freezing tolerance is conditioned by the C-repeat binding factor (CBF) gene regulon. We investigated whether the level of freezing tolerance of 12 winter wheat lines varied throughout the day and night in plants grown under a constant low temperature and a 12-hour photoperiod. Freezing tolerance was significantly greater (P<0...
2018: PloS One
https://www.readbyqxmd.com/read/29912760/the-role-of-insulin-like-growth-factor-igf-axis-in-early-diagnosis-of-pancreatic-adenocarcinoma-pdac
#10
Barbara Wlodarczyk, Anita Gasiorowska, Ewa Malecka-Panas
New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912580/effects-of-pacifier-use-on-transition-time-from-gavage-to-breastfeeding-in-preterm-infants-a-randomized-controlled-trial
#11
Birgul Say, Gulsum Kadioglu Simsek, Fuat Emre Canpolat, Serife Suna Oguz
BACKGROUND: Nonnutritive sucking (NNS) has been identified as having many benefits for preterm infants. NNS may improve the efficacy of oral feeding, reduce the length of time spent in orogastric (OG) tube feeding, and shorten the length of hospital stays for preterm infants. AIM: This study aimed to assess the effect of pacifiers on preterm infants in the transition from gavage to oral feeding, their time to discharge, weight gain, and time for transition to full breastfeeding...
June 18, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29912554/interface-assisted-synthesis-of-2d-materials-trend-and-challenges
#12
Renhao Dong, Tao Zhang, Xinliang Feng
The discovery of graphene one decade ago has triggered enormous interest in developing two-dimensional materials (2DMs)-that is 2D allotropes of various elements or compounds (consisting of two or more covalently bonded elements) or molecular frameworks with periodic structures. At present, various synthesis strategies have been exploited to produce 2DMs, such as top-down exfoliation and bottom-up chemical vapor deposition and solution synthesis methods. In this review article, we will highlight the interfacial roles toward the controlled synthesis of inorganic and organic 2DMs with varied structural features...
June 18, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29912472/functional-characterization-of-plasmodium-falciparum-surface-related-antigen-pfsra-as-a-potential-blood-stage-vaccine-target
#13
Emmanuel Amlabu, Henrietta Mensah-Brown, Prince B Nyarko, Ojo-Ajogu Akuh, Grace Opoku, Philip Ilani, Richard Oyagbenro, Kwame Asiedu, Yaw Aniweh, Gordon A Awandare
Plasmodium falciparum erythrocyte invasion is a multi-step process that involves a spectrum of interactions that are not well characterized. We have characterized a 113 kDa immunogenic protein PF3D7_1431400 (PF14_0293) that possesses coiled-coil structures. The protein is localized on the surfaces of both merozoites and gametocytes, hence the name PlasmodiumfalciparumSurface Related Antigen (PfSRA). The processed 32 kDa fragment of PfSRA binds normal human erythrocytes with different sensitivities to enzyme treatments...
April 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29912467/trans-disciplinary-advanced-allied-health-practitioners-for-acute-hospital-inpatients-a-feasibility-study
#14
Dina Watterson, Kerrie Walter, Lisa O'Brien, Desiree Terrill, Kathleen Philip, Indi Swan, Lisa Somerville
Objective: To explore cost-efficiency, safety and acceptability of trans-disciplinary advanced allied health (AH) practitioners for acute adult general medicine inpatients. Design: Quasi-experimental feasibility study. Setting: Three acute general medical units in an Australian urban hospital. Participants: Two hundred and fifty-six acute hospital inpatients. Main Outcome Measures: Cost-efficiency measures included AH service utilization and length of stay (LOS)...
June 15, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29912430/body-size-and-gastrointestinal-morphology-of-nutria-myocastor-coypus-reared-on-an-extensive-or-intensive-feeding-regime
#15
Robert Glogowski, William Pérez, Marcus Clauss
Although plasticity of growth rates is mainly associated with ectotherm species, it does occur in endotherms as well, but has not been documented systematically for many species. We compared the effect of two common types of feeding systems, differing in energetic value, on body size and gastrointestinal tract morphology in nutrias (Myocastor coypus). A total of 30 extensively (E) fed and 20 intensively (I) fed animals were used in the study. We noted significant effects of age, sex and feeding regime on body weight and length, with one-year-old females attaining 3...
June 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29912353/nutritional-impact-on-mammary-development-in-pigs-a-review
#16
Chantal Farmer
Milk yield is a crucial component of a sow operation because it is a limiting factor for piglet growth rate. Stimulating mammary development is one avenue that could be used to improve sow milk production. A number of studies have shown that nutrition of gilts or sows during the periods of rapid mammary accretion occurring during prepuberty, gestation, and lactation can affect mammary development. The present review provides an overview of all the information currently published on the subject and Table 1 summarizes the dietary treatments that enhance mammary development in pigs...
June 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29912326/soils-associated-to-different-tree-communities-do-not-elicit-predictable-responses-in-lake-bacterial-community-structure-and-function
#17
Clara Ruiz-González, Esther Archambault, Isabelle Laforest-Lapointe, Paul A Del Giorgio, Steven W Kembel, Christian Messier, Charles A Nock, Beatrix E Beisner
Freshwater bacterioplankton communities are influenced by the inputs of material and bacteria from the surrounding landscape, yet few studies have investigated how different terrestrial inputs affect bacterioplankton. We examined whether the addition of soils collected under various tree species combinations differentially influences lake bacterial communities. Lake water was incubated for 6 days following addition of five different soils. We assessed the taxonomic composition (16S rRNA gene sequencing) and metabolic activity (Biolog Ecoplates) of lake bacteria with and without soil addition, and compared these to initial soil communities...
June 14, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29912301/subtropical-tritrophic-interactions-under-elevated-co2-and-temperature-conditions
#18
Papitchaya Teawkul, Shaw-Yhi Hwang
The effects of climate change and extreme weather conditions on plants and animals have been documented extensively. However, the possible effects of these factors on plant-insect interactions in subtropical regions are relatively unexplored. The present study investigated the consequences of elevated CO2 and temperature on a tritrophic system (plant-insect-parasitoid) in subtropical regions. The experimental conditions were as follows: ambient CO2, 500 ppm; elevated CO2, 1,000 ppm; ambient temperature, 24/21°C (day/night); and elevated temperature, 29/26°C (day/night)...
April 18, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29912292/oestrogen-fuels-the-growth-of-endometrial-hyperplastic-lesions-initiated-by-overactive-wnt-%C3%AE-catenin-signalling
#19
Jyoti Goad, Yi-An Ko, Manish Kumar, M Fairuz B Jamaluddin, Pradeep S Tanwar
Unopposed oestrogen results in approximately 80% of all the endometrial cancer patients. The relationship between unopposed oestrogen and endometrial cancer was indicated by the increase in the number of endometrial cancer cases due to the widespread use of oestrogen replacement therapy. Approximately 30% of the endometrial cancer patients have mutations in the Wnt signalling pathway. How the unbalanced ratios of ovarian hormones and the mutations in Wnt signalling pathway interact to cause endometrial cancer is currently unclear...
June 15, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29912235/-peripartum-cardiomyopathy-a-little-known-disease
#20
Angela Beatrice Scardovi, Renata De Maria
Peripartum cardiomyopathy (PPCM) is a relatively rare cardiac disease that manifests itself in the final stage of pregnancy and in the first months after delivery in women with no previous history of cardiovascular disease. The incidence of PPCM varies widely across geographic areas and seems to be on the rise as a result of increased awareness and socioeconomic changes. PPCM recognizes a still partially undefined multifactorial etiology. Various pathogenetic hypotheses have been proposed, that range from autoimmune mechanisms to myocarditis to the hormonal hypothesis for aberrant, antiangiogenic and cardiotoxic prolactin (PRL) production, apoptosis, prolonged exposure to tocolytic drugs, malnutrition and genetic predisposition...
April 2018: Giornale Italiano di Cardiologia
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