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https://www.readbyqxmd.com/read/28090569/mitogen-activated-protein-kinase-kinase-activity-maintains-acinar-to-ductal-metaplasia-and-is-required-for-organ-regeneration-in-pancreatitis
#1
Christopher J Halbrook, Hui-Ju Wen, Jeanine M Ruggeri, Kenneth K Takeuchi, Yaqing Zhang, Marina Pasca di Magliano, Howard C Crawford
BACKGROUND & AIMS: Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer, where its potential as a therapeutic target is limited by acquired drug resistance. However, its role in pancreatitis is less understood. We investigated the role of mitogen-activated protein kinase kinase (MEK)-initiated MAPK signaling in pancreatitis to determine the potential for MEK inhibition in treating pancreatitis patients...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28089436/the-significance-of-histologic-examination-of-gastrectomy-specimens-a-clinicopathologic-study-of-511-cases
#2
Pavel Kopach, Elizabeth M Genega, Sajani N Shah, Julie J Kim, Yvelisse Suarez
BACKGROUND: Sleeve gastrectomy (SG) is quickly becoming the preferred procedure for bariatric surgery. According to the American Society for Metabolic and Bariatric Surgery guidelines, routine preoperative upper gastrointestinal endoscopies are not recommended universally for bariatric surgery. Some studies have shown that the histologic examination of SG specimens is insignificant and not a cost-effective practice. However, some speculate SG examination may unveil pertinent findings and prevent further progression of precursor lesions...
November 15, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28089234/oncogenic-kras-induced-increase-in-fluid-phase-endocytosis-is-dependent-on-n-wasp-and-is-required-for-the-formation-of-pancreatic-preneoplastic-lesions
#3
Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M Schmid, Jens T Siveke
Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRas(G12D), which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have previously shown that KRas(G12D)-induced ADM is dependent on RAC1 and EGF receptor (EGFR) by a not fully clarified mechanism. Using three-dimensional mouse and human acinar tissue cultures and genetically engineered mouse models, we provide evidence that (i) KRas(G12D) leads to EGFR-dependent sustained fluid-phase endocytosis (FPE) during acinar metaplasia; (ii) variations in plasma membrane tension increase FPE and lead to ADM in vitro independently of EGFR; and (iii) that RAC1 regulates ADM formation partially through actin-dependent regulation of FPE...
December 24, 2016: EBioMedicine
https://www.readbyqxmd.com/read/28081334/comparison-of-the-distinctive-pathological-features-of-and-p16-and-c-kitexpression-levels-in-benign-and-malignant-endometrial-polyps
#4
Nermin Koç, Selçuk Ayas, Lütfiye Uygur, Nurver Özel Özbay
BACKGROUND/AIM: Histopathological examination is crucial for the effective management of endometrial polyps. Immunohistochemical markers such as p16 and c-Kit may facilitate the differential diagnoses of benign and malignant polyps. The aim of the present study was to explore the expression levels of c-Kit (CD117) and p16 in endometrial polyps of postmenopausal women. MATERIALS AND METHODS: Twenty-five hysterectomy specimens with malignant endometrial polyps and hysterectomy or polypectomy specimens featuring 55 benign polyps were studied...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079289/apocrine-metaplasia-found-at-mr-biopsy-is-there-something-to-be-learned
#5
Yiming Gao, Vandana Dialani, Carolynn DeBenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast lesions which underwent MR-guided biopsy, yielding ApoM on pathology analysis were included...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/28078907/the-diagnostic-value-of-confocal-laser-endomicroscopy-for-gastric-cancer-and-precancerous-lesions-among-asian-population-a-system-review-and-meta-analysis
#6
Hai-Ping Zhang, Sheng Yang, Wen-Hua Chen, Teng-Teng Hu, Jun Lin
OBJECTIVE: The objective of this study is to evaluate the diagnostic value of confocal laser endomicroscopy (CLE) in detection of gastric cancer (GC), gastric intraepithelial metaplasia (GIM), and gastric intraepithelial neoplasia (GIN) lesions. METHOD: PubMed, the Cochrane Library, and Wangfang databases were searched to include eligible articles about CLE in detection of gastric lesions. After study selection, quality assessment and data extraction conducted by two reviewers independently, meta-analysis was performed by Meta-Disc 1...
January 12, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28077338/10-day-bismuth-containing-quadruple-therapy-is-effective-as-first-line-therapy-for-helicobacter-pylori-related-chronic-gastritis-a-prospective-randomized-study-in-china
#7
Liangjing Wang, Zhenghua Lin, Shujie Chen, Jun Li, Chun Xiao Chen, Zhiming Huang, Bin Ye, Jin Ding, Wei Li, Lunpo Wu, Ying Jiang, Lina Meng, Qin Du, Jianmin Si
OBJECTIVES: To investigate the effectiveness of 10-day bismuth-containing quadruple (B-quadruple) treatment as first-line therapy in patients with Helicobacter pylori related chronic gastritis. METHODS: Randomized control trial conducted from Oct. 2011 to Dec. 2013 in Zhejiang, China, including patients with H. pylori-related chronic gastritis who were randomly given either 10-day omeprazole-based triple (OM-triple, omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1g twice daily), or 10-day B-quadruple therapy (OM-triple + bismuth subcitrate 120 mg four times daily)...
January 7, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28076500/histological-evaluation-of-capsules-formed-by-silicon-implants-coated-with-polyurethane-foam-and-with-a-textured-surface-in-rats
#8
Eduardo Nascimento Silva, Jurandir Marcondes Ribas-Filho, Nicolau Gregori Czeczko, Jan Pawel Andrade Pachnicki, Mário Rodrigues Montemor Netto, Leandro Cavalcante Lipinski, Lucia de Noronha, Joelmir Colman, João Otavio Zeni, Caroline Aragão de Carvalho
PURPOSE: To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS: Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed for 30, 50, 70 and 90 days. Were analyzed the following parameters: foreign body reaction, granulation tissue, presence of myofibroblasts, neoangiogenesis, presence of synovial metaplasia, capsular thickness, total area and collagen percentage of type I and III, in capsules formed around silicone implants in both groups...
December 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28072871/atrophic-and-metaplastic-progression-in-the-background-mucosa-of-patients-with-gastric-adenoma
#9
Hee Kyong Na, Charles J Cho, Suh Eun Bae, Jeong Hoon Lee, Young Soo Park, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Se Jin Jang, Hwoon-Yong Jung
BACKGROUND: In patients with adenoma, assessing premalignant changes in the surrounding mucosa is important for surveillance. This study evaluated atrophic and metaplastic progression in the background mucosa of adenoma or early gastric cancer (EGC) cases. METHODS: Among 146 consecutive patients who underwent endoscopic resection for intestinal-type gastric neoplasia, the adenoma group included 56 patients with low-grade dysplasia and the ECG group included 90 patients with high-grade dysplasia or invasive carcinoma...
2017: PloS One
https://www.readbyqxmd.com/read/28070930/pituitary-adenoma-with-adipose-tissue-a-new-metaplastic-variant
#10
Chiara Caporalini, Anna Maria Buccoliero, Luigi Pansini, Selene Moscardi, Luca Novelli, Gianna Baroni, Lorenzo Bordi, Franco Ammannati, Gian Luigi Taddei
Pituitary adenomas are benign tumors representing approximately 15-20% of intracranial neoplasms. There have been few reports of metaplastic osseous transformation and about 60 cases of neuronal metaplasia in pituitary adenoma but adipose metaplasia has not been previously described in the English literature. Here we report a case of pituitary adenoma with metaplastic adipose tissue in a 58-year-old male patient. Histologically this case fulfilled the criteria of a non-functioning pituitary adenoma, and moreover a central area of adipose tissue, made by mature adipocytes, and many tumor cells, containing fat droplet were evident...
January 9, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28070593/-morphological-investigations-of-deep-sole-ulcers-in-cattle-part-1-the-complicated-rusterholz-ulcer
#11
Susanne Gehringer, Matthias Müller, Johann Maierl
OBJECTIVE: In the context of a larger study on morphological changes of deep sole ulcers, claws with Rusterholz ulcer (RU) were investigated to describe the varied pathological changes of the RU. MATERIAL AND METHODS: Hind limbs of 55 cows displaying external signs of complicated sole ulcers were examined externally and internally. To examine the samples internally, a sagittal section was performed. Furthermore, the material was examined histologically and after bone maceration...
January 10, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28068894/strain-differences-in-a-murine-model-of-air-pollutant-induced-nonatopic-asthma-and-rhinitis
#12
Jack R Harkema, Lucas A Hotchkiss, Nicholas A Vetter, Daven N Jackson-Humbles, Ryan P Lewandowski, James G Wagner
Ozone is an irritating gas found in photochemical smog. Epidemiological associations have been made between the onset of asthma and childhood exposures to increasing levels of ambient ozone (i.e., air pollutant-induced nonatopic asthma). Individuals, however, vary in their susceptibility to this outdoor air pollutant, which may be due, in part, to their genetic makeup. The present study was designed to test the hypothesis that there are murine strain-dependent differences in pulmonary and nasal pathologic responses to repeated ozone exposures...
January 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28063114/histopathological-changes-in-laparoscopic-sleeve-gastrectomy-specimens-prevalence-risk-factors-and-value-of-routine-histopathologic-examination
#13
Tamer Safaan, Moataz Bashah, Walid El Ansari, Mohsen Karam
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is a common surgical therapeutic option for obese patients, with debate about the value of routine histopathologic examination of LSG specimens. We assessed the following: prevalence of different histopathologic changes in LSG specimens, risk factors associated with premalignant and with frequent histopathologic changes, and whether routine histopathologic examination is warranted for LSG patients with nonsignificant clinical history. METHODS: Retrospective review of records of all LSG patients operated upon at Hamad General Hospital, Qatar (February 2011-July 2014, n = 1555), was conducted...
January 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28058012/evolving-management-of-metaplasia-and-dysplasia-in-barrett-s-epithelium
#14
REVIEW
Richard P T Evans, Moustafa Mabrouk Mourad, Simon G Fisher, Simon R Bramhall
Oesophageal cancer affects more than 450000 people worldwide and despite continued medical advancements the incidence of oesophageal cancer is increasing. Oesophageal cancer has a 5 year survival of 15%-25% and now globally attempts are made to more aggressively diagnose and treat Barrett's oesophagus the known precursor to invasive disease. Currently diagnosis the of Barrett's oesophagus is predominantly made after endoscopic visualisation and histopathological confirmation. Minimally invasive techniques are being developed to improve the viability of screening programs...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28057438/oncogenic-kras-induced-increase-in-fluid-phase-endocytosis-is-dependent-on-n-wasp-and-is-required-for-the-formation-of-pancreatic-preneoplastic-lesions
#15
Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M Schmid, Jens T Siveke
Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRas(G12D), which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have previously shown that KRas(G12D)-induced ADM is dependent on RAC1 and EGF receptor (EGFR) by a not fully clarified mechanism. Using three-dimensional mouse and human acinar tissue cultures and genetically engineered mouse models, we provide evidence that (i) KRas(G12D) leads to EGFR-dependent sustained fluid-phase endocytosis (FPE) during acinar metaplasia; (ii) variations in plasma membrane tension increase FPE and lead to ADM in vitro independently of EGFR; and (iii) that RAC1 regulates ADM formation partially through actin-dependent regulation of FPE...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28053963/expression-of-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-and-cd44-potential-implications-for-gastric-cancer-stem-cell-marker
#16
Yoon Jin Choi, Nayoung Kim, Hye Seung Lee, Seon Mee Park, Ji Hyun Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The human leucine-rich repeat-containing G-protein coupled receptor (LGR) 5 and CD44 are one of the candidates for the marker of gastric cancer stem cells. We compared the expressions of two genes among control, dysplasia and cancer groups. METHODS: We compared the mRNA expression of LGR5, CD44 and CD44v8-10 and immunohistochemistry (IHC) of LGR5 and CD44 in gastric antral mucosa of 45 controls, 36 patients with gastric dysplasia, and 39 patients with early gastric cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28049442/analyzing-the-influence-of-gastric-intestinal-metaplasia-on-gastric-ulcer-healing-in-helicobacter-pylori-infected-patients-without-atrophic-gastritis
#17
Li-Wei Chen, Liang-Che Chang, Chung-Ching Hua, Bor-Jen Hsieh, Shuo-Wei Chen, Rong-Nan Chien
BACKGROUND: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with IM and those without IM. METHODS: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period from March 2005 to January 2011...
January 3, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28044300/a-mimicker-of-gallbladder-carcinoma-cystic-gastric-heterotopia-with-intestinal-metaplasia
#18
Gonca Özgün, Şaduman Balaban Adim, Nesrin Uğraş, Sadık Kiliçturgay
Heterotopic gastric mucosa in the gallbladder is an unusual entity and is usually clinically silent. We report a 75-year-old female patient who presented with intermittent upper abdomial pain radiating to the back. Abdominal imaging studies showed a sessile polypoid lesion and a gallstone in the gallbladder. Gallbladder carcinoma was suspected and cholecystectomy performed. Intraoperative frozen section examination suggested mucinous tumor, suspicious for malignancy. However, the permanent sections revealed aberrant gastric tissue consisted of gastric pyloric and fundic glands of heterotopic gastric mucosa with intestinal metaplasia in the gallbladder...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28038714/gastric-mucosal-status-susceptible-to-lanthanum-deposition-in-patients-treated-with-dialysis-and-lanthanum-carbonate
#19
Shinichi Ban, Syunji Suzuki, Kenji Kubota, Susumu Ohshima, Hideaki Satoh, Hiroki Imada, Yoshihiko Ueda
Lanthanum carbonate is a popular chemical which is administered for patients with end-stage kidney disease to reduce the absorption of phosphate, and lanthanum deposition in the gastroduodenal mucosa has recently been reported. The aim of this study was to assess whether any histologic changes of the gastric mucosa are related to the deposition of lanthanum. Twenty-four patients who revealed the histology of lanthanum deposition on gastroduodenal biopsy between 2011 and 2014 were included in the study, and their clinical records and gastroduodenal biopsies obtained from 2011 to 2015 were reviewed, adding the review of gastroduodenal biopsies before 2011 if possible...
February 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28035705/a-rare-case-of-cutaneous-oncocytic-hidradenoma
#20
Shivani P Reddy, Kim Chong, David S Cassarino
Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Oncocytomas, or tumors composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. Oncocytic metaplasia has only been rarely reported in various cutaneous neoplasms. We report a case of an elderly male presenting with a 5 millimeter erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based adnexal tumor with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged, bland-appearing epithelioid cells...
December 30, 2016: Journal of Cutaneous Pathology
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