Mehmet Özkan, Ahmet Güner, Sabahattin Gündüz, Gazi Yıldız, Ayşe İnci Yıldırım, Macit Kalçık, Mahmut Yesin, Emrah Bayam, Semih Kalkan, Mustafa Ozan Gürsoy, Alev Kılıçgedik, Zübeyde Bayram, Münevver Sarı, Mehmet Aytürk, Süleyman Karakoyun, Mehmet Ali Astarcıoğlu, Elif Cansu Gündoğdu, Asuman Biçer, Emre Gürcü, Tuncer Koçak, Recep Demirbağ
BACKGROUND: Optimal first-trimester anticoagulation is still challenging in pregnant women with mechanical heart valves (MHVs) requiring high-dose warfarin.This multicenter prospective study aims to determine the optimal anticoagulation regimens for pregnant patients with MHVs. METHODS: All women were allocated to one of three treatment options during first trimester including lone low-molecular-weight heparin (LMWH), combination of LMWH+2.5 mg warfarin, and LMWH+4 mg warfarin...
April 1, 2024: American Heart Journal