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https://www.readbyqxmd.com/read/29137116/altering-residue-134-confers-an-increased-substrate-range-of-alkylated-nucleosides-to-the-e-coli-ogt-protein
#1
Nadia M Schoonhoven, Derek K O'Flaherty, Francis P McManus, Lauralicia Sacre, Anne M Noronha, M Judith Kornblatt, Christopher J Wilds
O⁶-Alkylguanine-DNA alkyltransferases (AGTs) are proteins responsible for the removal of mutagenic alkyl adducts at the O⁶-atom of guanine and O⁴-atom of thymine. In the current study we set out to understand the role of the Ser134 residue in the Escherichia coli AGT variant OGT on substrate discrimination. The S134P mutation in OGT increased the ability of the protein to repair both O⁶-adducts of guanine and O⁴-adducts of thymine. However, the S134P variant was unable, like wild-type OGT, to repair an interstrand cross-link (ICL) bridging two O⁶-atoms of guanine in a DNA duplex...
November 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29116582/late-onset-first-episode-psychosis-emerging-as-delusional-misidentification-of-familiar-sacred-places-during-a-holy-pilgrimage-a-case-report-and-literature-review
#2
Mahmoud A Awara, Hamdy F Moselhy, Manal O Elnenaei
BACKGROUND: The delusional misidentification syndromes (DMS) include a myriad of discrete but related syndromes, which have wide spectrum anomalies of familiarity. Several misidentification syndromes have been described in the psychiatric literature, the most common of these delusions are: the Capgras syndrome; the Fregoli syndrome; the syndrome of inter-metamorphosis; reduplicative paramnesia; and environmental reduplication. CASE PRESENTATION: The reported case highlights the emergence of late onset first episode psychosis in a Middle Eastern 65-year-old female who has no previous psychiatric history...
November 7, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29115917/the-complete-chloroplast-genome-of-primulina-and-two-novel-strategies-for-development-of-high-polymorphic-loci-for-population-genetic-and-phylogenetic-studies
#3
Chao Feng, Meizhen Xu, Chen Feng, Eric J B von Wettberg, Ming Kang
BACKGROUND: Primulina Hance is an emerging model for studying evolutionary divergence, adaptation and speciation of the karst flora. However, phylogenetic relationships within the genus have not been resolved due to low variation detected in the cpDNA regions. Chloroplast genomes can provide important information for phylogenetic and population genetic studies. Recent advances in next-generation sequencing (NGS) techniques greatly facilitate sequencing whole chloroplast genomes for multiple individuals...
November 7, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29094518/disparities-in-rate-triggers-and-management-in-pediatric-and-adult-cases-of-suspected-drug-induced-anaphylaxis-in-canada
#4
REVIEW
Sofianne Gabrielli, Ann E Clarke, Harley Eisman, Judy Morris, Lawrence Joseph, Sebastien La Vieille, Peter Small, Rodrick Lim, Paul Enarson, Michal Zelcer, Edmond S Chan, Chris Mill, Moshe Ben-Shoshan
INTRODUCTION: Data is sparse on drug-induced anaphylaxis (DIA) and there have not been studies assessing the differences in clinical characteristics and management of DIA between adults and children. OBJECTIVE: We assessed the percentage, diagnosis, and management of DIA among all anaphylaxis visits in three pediatric and one adult emergency departments (ED) across Canada. METHODS: Children presenting to the Montreal Children's Hospital (MCH), British Columbia Children's Hospital (BCCH), and Children's Hospital at London Health Sciences Center and adults presenting to Hôpital du Sacré-Coeur with anaphylaxis were recruited as part of the Cross-Canada Anaphylaxis Registry...
November 1, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29082780/textual-healing-tailor-made-kabbalistic-therapeutics-in-jerusalem
#5
Shlomo Guzmen-Carmali, Asaf Sharabi
This paper, based on fieldwork conducted in a Jerusalem yeshiva, describes how the yeshiva, a traditional institute of religious studies, also serves as an institution of healing and personal therapy in which sacred religious texts assume a central place. The article focuses on personal sessions between the rabbi who heads the yeshiva, and his audience of believers who turn to him for help in coping with personal hardships and tribulations. The paper contextualizes and elaborates upon the concept of 'deep healing' to describe how the rabbi uses his regular 'tool kit' to diagnose the problems of the person facing him and to offer optimal, personalized therapy...
October 30, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/29081384/secondary-laparoscopic-cytoreduction-in-recurrent-ovarian-cancer-a-large-single-institution-experience
#6
Gallotta Valerio, Conte Conte, Giudice Maria Teresa, Nero Camilla, Vizzielli Giuseppe, Gueli Alletti Salvatore, Cianci Stefano, Lodoli Claudio, Di Giorgio Andrea, De Rose Agostino Maria, Fagotti Anna, Scambia Giovanni, Ferrandina Gabriella
STUDY OBJECTIVE: To analyze the feasibility and safety of laparoscopic secondary cytoreductive surgery in a retrospective series of platinum sensitive recurrent ovarian cancer patients. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Catholic University of the Sacred Hearth, Rome, Italy. PATIENTS: Between October 2010 and October 2016, 58 patients with recurrent ovarian cancer were selected for a retrospective analysis of data...
October 25, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29065881/the-implications-of-ritual-practices-and-ritual-plant-uses-on-nature-conservation-a-case-study-among-the-naxi-in-yunnan-province-southwest-china
#7
Yanfei Geng, Guoxiong Hu, Sailesh Ranjitkar, Yinxian Shi, Yu Zhang, Yuhua Wang
BACKGROUND: Conservation of biodiversity is primary important of today's critically vulnerable environment. Efficient conservation can be possible only with the long-term participation and understanding of the communities. Ritual beliefs of the indigenous people are one of the important tools to understand the local communities and aid the nature conservation. In this paper, we documented contemporary ritual practices and ritual plant uses among the Naxi people and discussed the importance of traditional knowledge on ritual practice in the conservation of plants in the mountains presenting a case study of the Dongba culture...
October 25, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29064366/spot-protein-creatinine-ratio-and-spot-albumin-creatinine-ratio-in-the-assessment-of-pre-eclampsia-a-diagnostic-accuracy-study-with-decision-analytic-model-based-economic-evaluation-and-acceptability-analysis
#8
Jason Waugh, Richard Hooper, Edmund Lamb, Stephen Robson, Andrew Shennan, Fiona Milne, Christopher Price, Shakila Thangaratinam, Vladislav Berdunov, Jenn Bingham
BACKGROUND: The National Institute for Health and Care Excellence (NICE) guidelines highlighted the need for 'large, high-quality prospective studies comparing the various methods of measuring proteinuria in women with new-onset hypertensive disorders during pregnancy'. OBJECTIVES: The primary objective was to evaluate quantitative assessments of spot protein-creatinine ratio (SPCR) and spot albumin-creatinine ratio (SACR) in predicting severe pre-eclampsia (PE) compared with 24-hour urine protein measurement...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29064071/tuskegee-as-sacred-rhetoric-focal-point-for-the-emergent-field-of-african-american-religion-and-health
#9
Terri Laws
Scholars in African American religion engage the Tuskegee Syphilis Study as the focal point of the African American experience in institutional medicine. Seeking a way forward from this history and its intentional evil, the author proposes to position Tuskegee as a form of Lynch's culturally contextual sacred rhetoric to make use of its metaphoric value in the emerging field of African American religion and health. In this broader meaning-making frame, Tuskegee serves as a reminder that African American religious sensibility has long been an agential resource that counters abuse of the Black body...
October 24, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29060742/modeling-electrical-stimulation-of-mammalian-nerve-fibers-a-mechanistic-versus-probabilistic-approach
#10
Vijay Sadashivaiah, Pierre Sacre, Yun Guan, William S Anderson, Sridevi V Sarma
Electrical neurostimulation is increasingly used over neuropharmacology to treat various diseases. Despite efforts to model the effects of electrical stimulation, its underlying mechanisms remain unclear. This is because current mechanistic models just quantify the effects that the electrical field produces near the fiber and do not capture interactions between stimulus-initiated action potentials (APs) and underlying physiological activity initiated APs. In this study, we aim to quantify and compare these interactions...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060612/nonmotor-regions-encode-path-related-information-during-movements
#11
Macauley S Breault, Pierre Sacre, Jacob J Johnson, Matthew Kerr, Matthew D Johnson, Juan Bulacio, Jorge Gonzalez-Martinez, Sridevi V Sarma, John T Gale
Sensorimotor control and the involvement of motor brain regions has been extensively studied, but the role nonmotor brain regions play during movements has been overlooked. This is particularly due to the difficulty of recording from multiple regions in the brain during motor control. In this study, we utilize stereoelectroencephalography (SEEG) recording techniques to explore the role nonmotor brain areas have on the way we move. Nine humans were implanted with SEEG depth electrodes for clinical purposes, which rendered access to local field potential (LFP) activity in deep and peripheral nonmotor structures...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060406/the-role-of-nonmotor-brain-regions-during-human-motor-control
#12
Jacob J Johnson, Macauley S Breault, Pierre Sacre, Matthew S D Kerr, Mathew Johnson, Juan Bulacio, Jorge Gonzalez-Martinez, Sridevi V Sarma, John T Gale
Neural prostheses have generally relied on signals from cortical motor regions to control reaching movements of a robotic arm. However, little work has been done in exploring the involvement of nonmotor cortical and associative regions during motor tasks. In this study, we identify regions which may encode direction during planning and movement of a center-out motor task. Local field potentials were collected using stereoelectroencephalography (SEEG) from nine epilepsy patients implanted with multiple depth electrodes for clinical purposes...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060033/neuronal-activity-in-human-anterior-cingulate-cortex-modulates-with-internal-cognitive-state-during-multi-source-interference-task
#13
Samuel Sklar, Matthew Walmer, Pierre Sacre, Catherine A Schevon, Shraddha Srinivasan, Garrett P Banks, Mark J Yates, Guy M McKhann, Sameer A Sheth, Sridevi V Sarma, Elliot H Smith
The dorsal anterior cingulate cortex (dACC) is thought to be essential for normal adaptation of one's behavior to difficult decisions, errors, and reinforcement. Here we examine single neurons from the human dACC in the context of a statistical model, including a cognitive state that varies with changes in cognitive interference induced by a Stroop-like task. We then include this cognitive state in point process models of single unit activity and subject reaction time. These results suggest that consideration of a latent cognitive state can explain additional variance in neural and behavioral dynamics...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053527/a-paradigm-shift-from-brick-and-mortar-full-time-nursing-faculty-off-campus
#14
Marlene Beck, Holly B Bradley, Linda L Cook, Joslin B Leasca, Tammy Lampley, JoAnne Gatti-Petito
The organizational structure for the Master of Science in Nursing's online program at Sacred Heart University offers a remarkably different innovative faculty model. Full-time, doctorally prepared faculty reside in several different states and teach online but are fully integrated and immersed in all aspects of the college of nursing. This untraditional model, which has proven to be successful over time using best practices for online education, is replicable and offers an innovative option for online learning...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29052958/whole-genome-re-sequencing-reveals-evolutionary-patterns-of-sacred-lotus-nelumbo-nucifera
#15
Longyu Huang, Mei Yang, Ling Li, Hui Li, Dong Yang, Tao Shi, Pingfang Yang
Sacred lotus (Nelumbo nucifera or lotus) is an important aquatic plant in horticulture and ecosystem. As a foundation for exploring genomic variationand evolution among different germplasms, we re-sequenced 19 individuals from three cultivated temperate lotus subgroups (rhizome lotus, seed lotus and flower lotus),one wild temperate lotus subgroup (wild lotus), one tropical lotus group (Thai lotus) and outgroup (Nelumbo lutea). Through genetic diversity and polymorphism analysis by non-missing SNP sites widely distributed in the whole genome, weconfirmed that wild lotus and Thai lotus exhibited greater differentiation with a higher genomic diversity compared to cultivated lotus...
October 20, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/28966508/plasma-cell-cheilitis-a-clinicopathological-and-immunohistochemical-study-of-13-cases
#17
Jin Yong Lee, Kwang Ho Kim, Ji Eun Hahm, Jae Won Ha, Won Joo Kwon, Chul Woo Kim, Sang Seok Kim
BACKGROUND: Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. METHODS: The present study investigated the clinical manifestations, treatment modalities, and outcome of 13 patients diagnosed with plasma cell cheilitis from 2011 to 2016 at Kangdong Sacred Heart Hospital and Hallym University Sacred Heart Hospital...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28954294/mild-cognitive-impairment-is-associated-with-subclinical-diastolic-dysfunction-in-patients-with-chronic-heart-disease
#18
Julian W Sacre, Jocasta Ball, Chiew Wong, Yih-Kai Chan, Simon Stewart, Bronwyn A Kingwell, Melinda J Carrington
Background: To examine mild cognitive impairment and its associations with subclinical cardiac dysfunction in patients with chronic heart disease yet to develop the clinical syndrome of chronic heart failure (CHF). Methods and results: Patients from the Nurse-led Intervention for Less Chronic Heart Failure Study (n = 373 with chronic heart disease other than CHF; 64 ± 11 years, 69% men) were screened for mild cognitive impairment [Montreal cognitive assessment (MoCA) score <26] and underwent echocardiographic/clinical profiling...
August 7, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28949125/recovery-of-acid-gas-degraded-zeolitic-imidazolate-frameworks-by-solvent-assisted-crystal-redemption-sacred
#19
Krishna C Jayachandrababu, Souryadeep Bhattacharyya, Yadong Chiang, David S Sholl, Sankar Nair
The acid stability of zeolitic imidazolate frameworks (ZIFs) is an important issue hindering their application. Acid-gas damage of ZIFs has been considered irreversible. However, we demonstrate a methodology called solvent-assisted crystal redemption (SACRed) to reverse acid-gas damage to ZIFs with a high degree of structural and functional recovery. For example, post-SACRed ZIF-8 is shown to be structurally and chemically near-identical with the original pristine ZIF-8 that suffered a large loss of surface area, porosity, and crystallinity during acid-gas exposure...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28948447/gender-by-dasein-a-heideggerian-critique-of-suzanne-kessler-and-the-medical-management-of-infants-born-with-disorders-of-sexual-development
#20
Lauren L Baker
This article explores the relationship between gender, technology, language, and how infants and children born with disorders of sexual development are shaped into intelligible members of the community. The contemporary medical model maintains that children ought to be both socially and surgically assigned and reared as one particular gender. Gender scholar Suzanne Kessler rejects this position and argues for the acceptance of greater genital variability through the use of language. Using a Heideggerian lens, the main question I seek to answer in this article is: does Kessler's approach succeed in its aim to better treat individuals born with disorders of sexual development? I argue that Kessler is successful in offering practical solutions for persons with intersexed conditions to exist and flourish as intelligible members of the community, but that her project ultimately relies on power to "challenge forth" greater acceptance of genital variance...
September 25, 2017: Theoretical Medicine and Bioethics
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