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https://www.readbyqxmd.com/read/29684891/considering-high-alcohol-and-violence-neighborhood-context-using-daily-diaries-and-gps-a-pilot-study-among-people-living-with-hiv
#1
Katherine P Theall, Erica Felker-Kantor, Maeve Wallace, Xiao Zhang, Christopher N Morrison, Douglas J Wiebe
Our understanding of how community-level context impacts care of persons living with HIV (PLWH), including antiretroviral therapy (ART) adherence and retention in care, is limited. The objective of this study was to characterize the activity spaces of PLWH from an urban area in Southeastern U.S., where the epidemic is among the nation's highest, and to examine how such activity spaces are associated with daily mood and health behaviors. In this small, pilot study, 11 participants were tracked with a global positioning system (GPS)-enabled application on their smartphones for 2 weeks...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684651/the-geography-of-smallpox-in-england-before-vaccination-a-conundrum-resolved
#2
Romola Jane Davenport, Max Satchell, Leigh Matthew William Shaw-Taylor
Smallpox is regarded as an ancient and lethal disease of humans, however very little is known about the prevalence and impact of smallpox before the advent of vaccination (c.1800). Here we use evidence from English burial records covering the period 1650-1799 to confirm a striking geography to smallpox patterns. Smallpox apparently circulated as a childhood disease in northern England and Sweden, even where population densities were low and settlement patterns dispersed. However, smallpox was a relatively rare epidemic disease in southern England outside the largest cities, despite its commercialised economy and the growing spatial interconnectedness of its settlements...
April 16, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684471/glucocorticoid-receptors-in-the-basolateral-amygdala-mediated-the-restraint-stress-induced-reinstatement-of-methamphetamine-seeking-behaviors-in-rats
#3
Zahra Taslimi, Abdolrahman Sarihi, Abbas Haghparast
Methamphetamine (METH) addiction is a growing epidemic worldwide. It is a common psychiatric disease and stress has an important role in the drug seeking and relapse behaviors. The involvement of the basolateral amygdala (BLA) in effects of stress on the reward pathway has been discussed in several studies. In this study, we tried to find out the involvement of glucocorticoid receptors (GRs) in the BLA in stress-induced reinstatement of the extinguished METH-induced conditioned place preference (CPP) in rats...
April 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29684417/the-u-s-opioid-epidemic-one-disease-diverging-tales
#4
Ryan McBain, Adam J Rose, Marc R LaRochelle
No abstract text is available yet for this article.
April 20, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29684292/elevated-blood-pressure-and-its-predictors-among-secondary-school-students-in-sarawak-a-cross-sectional-study
#5
Woei Feng Grace Kho, Whye Lian Cheah, Helmy Hazmi
OBJECTIVES: Hypertension is a health issue affecting adolescents. Accumulating evidence affirms that elevated blood pressure begins in childhood and tracks into adulthood. This cross-sectional study was conducted to determine the prevalence of elevated blood pressure and its predictors among secondary school students in Sarawak, Malaysia. METHODS: A total of 2,461 secondary school students aged 12-17 years from 19 schools in Sarawak participated in the study. Questionnaire was used to obtain socio-demographic data, parental history of hypertension, and self-reported physical activity...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684054/-i-was-referred-from-the-other-side-gender-and-hiv-testing-among-older-south-africans-living-with-hiv
#6
Enid Schatz, Lucia Knight
South Africa has a Universal Test and Treat (UTT) policy in place to ensure that everyone tests for HIV and can access treatment if they test positive. The aim of this study is to document the pathways that older South Africans who are living with HIV take to access testing and treatment in this context. Despite the aging of the HIV epidemic in South Africa and clear evidence that testing older persons (over age 50) is necessary, very little is known about the circumstances under which older persons test for HIV or their motivations for doing so...
2018: PloS One
https://www.readbyqxmd.com/read/29683994/a-spatial-temporal-analysis-of-hiv-associated-mortality-in-rural-western-kenya-2011-2015
#7
Peter Sifuna, Lucas Otieno, Ben Andagalu, Janet Oyieko, Bernhards Ogutu, Valentine Singoei, John Owuoth, Sheila Ogwang, Jessica Cowden, Walter Otieno
BACKGROUND: Reliable data on the HIV epidemic is critical for the measurement of the impact of HIV response and for the implementation of further interventions. METHODS: We used mortality data from the Kombewa Health and Demographic Surveillance Systems (HDSS) from 1 January 2011-31 December 2015 to examine the space-time pattern of HIV-associated mortality. HIV mortality rate was calculated per 1,000 PLHV (for comparison with regional and national averages) and per 1,000 person-years (p-y) for comparison with other HDSS sites...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29682806/biomarkers-for-heart-failure-small-molecules-with-high-clinical-relevance
#8
REVIEW
C Magnussen, S Blankenberg
Heart failure (HF) is a rising epidemic due to the ageing population and progress in all areas of medicine. Thus, research efforts are made to ensure a timely diagnosis, to improve prognosis and treatment of the disease and to facilitate risk prediction at the population level. Because of their noninvasive determination with mostly high sensitivity and accuracy, circulating blood biomarkers are becoming increasingly important for daily clinical practice. Natriuretic peptides, especially B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and midregional pro-atrial natriuretic peptide (MR-proANP) and cardiac troponins are established blood biomarkers in HF diagnosis and prognosis of HF-related outcomes...
April 22, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#9
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29682297/safety-and-pharmacokinetics-of-dolutegravir-in-hiv-positive-pregnant-women-a-systematic-review
#10
EDITORIAL
Andrew Hill, Polly Clayden, Claire Thorne, Rachel Christie, Rebecca Zash
Background: The integrase strand transfer inhibitor dolutegravir (DTG) is being introduced into low- and middle-income countries (LMICs) as an alternative to first-line treatment with non-nucleoside reverse transcriptase inhibitors. However, DTG is not yet widely recommended for use in pregnant women. The aim of this systematic review was to analyse all available data on birth outcomes and congenital anomalies in the infants of pregnant women treated with DTG. Methods: A PubMed and Embase search was conducted using the terms "dolutegravir" or "DTG" and "pregnancy" or "pregnant" from the earliest available date on the database to 26 July 2017...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29681998/global-dynamics-of-an-avian-influenza-a-h7n9-epidemic-model-with-latent-period-and-nonlinear-recovery-rate
#11
Rui Mu, Youping Yang
An SEIR type of compartmental model with nonlinear incidence and recovery rates was formulated to study the combined impacts of psychological effect and available resources of public health system especially the number of hospital beds on the transmission and control of A(H7N9) virus. Global stability of the disease-free and endemic equilibria is determined by the basic reproduction number as a threshold parameter and is obtained by constructing Lyapunov function and second additive compound matrix. The results obtained reveal that psychological effect and available resources do not change the stability of the steady states but can indeed diminish the peak and the final sizes of the infected...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29681898/the-versatile-mutational-resistome-of-pseudomonas-aeruginosa
#12
REVIEW
Carla López-Causapé, Gabriel Cabot, Ester Del Barrio-Tofiño, Antonio Oliver
One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for developing antimicrobial resistance to nearly all available antipseudomonal agents through the selection of chromosomal mutations, leading to the failure of the treatment of severe hospital-acquired or chronic infections. Recent whole-genome sequencing (WGS) data obtained from in vitro assays on the evolution of antibiotic resistance, in vivo monitoring of antimicrobial resistance development, analysis of sequential cystic fibrosis isolates, and characterization of widespread epidemic high-risk clones have provided new insights into the evolutionary dynamics and mechanisms of P...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29681249/endemic-infection-of-the-common-mynah-acridotheres-tristis-with-trichomonas-gallinae-the-agent-of-avian-trichomonosis
#13
Hassan Ali Farooq, Hammad Ahmad Khan, Abdulwahed Fahad Alrefaei, Kevin Morris Tyler
Avian trichomonosis is an architypal disease of wild columbids and those birds that predate them. Increasingly though, it has been reported in passerines; a recent and ongoing epidemic in the chaffinches and greenfinches of Europe and outbreaks amongst house finches, American goldfinches and purple finches in North America. The parasite, Trichomonas gallinae, causes lesions in the upper respiratory tract which can cause mortality associated with dehydration and emaciation. This paper reports for the first time, the widespread, endemic and often asymptomatic infection of common mynah (Acridotheres tristis) around the Faisalabad District, Pakistan...
April 23, 2018: Parasitology
https://www.readbyqxmd.com/read/29681019/high-percentage-pathological-findings-in-obese-patients-suggest-that-esophago-gastro-duodenoscopy-should-be-made-mandatory-prior-to-bariatric-surgery
#14
Mizelle D'Silva, Aparna Govil Bhasker, Nimisha S Kantharia, Muffazal Lakdawala
ᅟ: Obesity is a global epidemic and will soon become the number one priority in healthcare management. Bariatric surgery causes a significant improvement in obesity and its related complications. Pre-operative esophago-gastro-duodenoscopy (EGD) is done by several bariatric surgical teams across the world but is still not mandatory. AIM: To study the percentage of symptomatic and asymptomatic pathological EGD findings in obese patients undergoing bariatric surgery and to analyze whether these findings influence the eventual choice of bariatric surgery...
April 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29679542/treatments-for-diabetes-mellitus-type-ii-new-perspectives-regarding-the-possible-role-of-calcium-and-camp-interaction
#15
REVIEW
Diego Soares Carvalho, Alexandre Aparecido de Almeida, Aurélio Ferreira Borges, Diego Vannucci Campos
Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29679440/effects-of-a-prior-authorization-policy-for-extended-release-long-acting-opioids-on-utilization-and-outcomes-in-a-state-medicaid-program
#16
Shellie L Keast, Hyunjee Kim, Richard A Deyo, Luke Middleton, K John McConnell, Kun Zhang, Sharia M Ahmed, Nancy Nesser, Daniel M Hartung
BACKGROUND AND AIMS: In response to the opioid overdose epidemic, USA state Medicaid programs have adopted restrictive policies for opioid analgesics, yet effects on prescribing patterns and health outcomes are uncertain. This study aimed to examine effects of a prior authorization policy for extended-release/long-acting (ER/LA) opioids on opioid use in the Oklahoma, USA state Medicaid program. DESIGN: Retrospective difference-in-differences design study comparing changes in opioid use in Oklahoma Medicaid to control (Oregon Medicaid)...
April 20, 2018: Addiction
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#17
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29678561/distribution-of-take-home-opioid-antagonist-kits-during-a-synthetic-opioid-epidemic-in-british-columbia-canada-a-modelling-study
#18
Michael A Irvine, Jane A Buxton, Michael Otterstatter, Robert Balshaw, Reka Gustafson, Mark Tyndall, Perry Kendall, Thomas Kerr, Mark Gilbert, Daniel Coombs
BACKGROUND: Illicit use of high-potency synthetic opioids has become a global issue over the past decade. This misuse is particularly pronounced in British Columbia, Canada, where a rapid increase in availability of fentanyl and other synthetic opioids in the local illicit drug supply during 2016 led to a substantial increase in overdoses and deaths. In response, distribution of take-home naloxone (THN) overdose prevention kits was scaled up (6·4-fold increase) throughout the province...
April 17, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29678552/the-immunogenicity-of-recombinant-vaccines-based-on-modified-vaccinia-ankara-mva-viruses-expressing-african-horse-sickness-virus-vp2-antigens-depends-on-the-levels-of-expressed-vp2-protein-delivered-to-the-host
#19
Eva Calvo-Pinilla, Simon Gubbins, Peter Mertens, Javier Ortego, Javier Castillo-Olivares
African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside this region. The perceived risk of an AHS outbreak occurring in Europe has increased following the frequent epidemics caused in ruminants by bluetongue virus, closely related to AHSV. Attenuated vaccines for AHS are considered unsuitable for use in non-endemic countries due bio-safety concerns...
April 17, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29678361/chikungunya-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#20
Pravin Amin, Gisele Sampaio Silva, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Dilip R Karnad, Guy A Richards
Chikungunya is an arbovirus that is transmitted by the Aedes mosquito causing a febrile illness with periodic outbreaks in large parts of the world. In the last decade it has become a public health concern in a host of countries and has affected international tourists. In the vast majority of cases Chikungunya presents as an acute febrile illness, associated with rash, headache, myalgia and debilitating arthralgia or even polyarthritis. A small proportion of patients present atypically with nervous, ocular, renal, myocardial, respiratory and renal system involvement and may require ICU management...
April 7, 2018: Journal of Critical Care
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