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https://www.readbyqxmd.com/read/28944141/nationwide-trends-of-hospitalizations-for-cystic-fibrosis-in-the-united-states-from-2003-to-2013
#1
Abhinav Agrawal, Abhishek Agarwal, Dhruv Mehta, Rutuja R Sikachi, Doantrang Du, Janice Wang
Cystic fibrosis (CF) is a multisystem autosomal recessive genetic disorder with significant advances in early diagnosis and treatment in the last decade. It is important to provide updated information regarding these changing demographics as they also reflect a considerable improvement in survival. We analyzed the National Inpatient Sample Database (NIS) in the United States for all patients in which CF was the primary discharge diagnosis (ICD-9: 277.0-277.09) from 2003 to 2013 to evaluate the rate of hospitalizations and determine the cost and mortality associated with CF along with other epidemiological findings...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28934994/comparison-of-methods-for-estimating-contemporary-costs-an-application-to-liver-transplantation-in-the-united-kingdom
#2
Jeshika Singh, Louise Longworth
OBJECTIVES: Our study addresses the important issue of estimating treatment costs from historical data. It is a problem frequently faced by health technology assessment analysts. We compared four approaches used to estimate current costs when good quality contemporary data are not available using liver transplantation as an example. METHODS: First, the total cost estimates extracted for patients from a cohort study, conducted in the 1990s, were inflated using a published inflation multiplier...
September 22, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28934978/adaptation-of-the-2015-american-college-of-rheumatology-treatment-guideline-for-rheumatoid-arthritis-for-the-eastern-mediterranean-region-an-exemplar-of-the-grade-adolopment
#3
Andrea Darzi, Manale Harfouche, Thurayya Arayssi, Samar Alemadi, Khaled A Alnaqbi, Humeira Badsha, Farida Al Balushi, Bassel Elzorkany, Hussein Halabi, Mohammed Hamoudeh, Wissam Hazer, Basel Masri, Mohammed A Omair, Imad Uthman, Nelly Ziade, Jasvinder A Singh, Robin Christiansen, Peter Tugwell, Holger J Schünemann, Elie A Akl
BACKGROUND: It has been hypothesized that adaptation of health practice guidelines to the local setting is expected to improve their uptake and implementation while cutting on required resources. We recently adapted the published American College of Rheumatology (ACR) Rheumatoid Arthritis (RA) treatment guideline to the Eastern Mediterranean Region (EMR). The objective of this paper is to describe the process used for the adaptation of the 2015 ACR guideline on the treatment of RA for the EMR...
September 21, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28925970/current-status-of-rift-valley-fever-vaccine-development
#4
REVIEW
Bonto Faburay, Angelle Desiree LaBeaud, D Scott McVey, William C Wilson, Juergen A Richt
Rift Valley Fever (RVF) is a mosquito-borne zoonotic disease that presents a substantial threat to human and public health. It is caused by Rift Valley fever phlebovirus (RVFV), which belongs to the genus Phlebovirus and the family Phenuiviridae within the order Bunyavirales. The wide distribution of competent vectors in non-endemic areas coupled with global climate change poses a significant threat of the transboundary spread of RVFV. In the last decade, an improved understanding of the molecular biology of RVFV has facilitated significant progress in the development of novel vaccines, including DIVA (differentiating infected from vaccinated animals) vaccines...
September 19, 2017: Vaccines
https://www.readbyqxmd.com/read/28923220/an-update-on-randomized-clinical-trials-in-melanoma
#5
REVIEW
Giorgos Karakousis, Charlotte Ariyan
Despite many advances in the treatment of melanoma, it still continues to be a disease that affects many people. Fortunately, there have been a multitude of randomized trials that have refined the treatment of this prevalent disease. From 1975 to 2000, there were 154 prospective randomized trials on the treatment of local, regional, and metastatic melanoma. From 2001 to now, additional randomized trials have focused on the role of surgery, adjuvants to surgery, and treatment of metastatic disease. The results of the practice-changing trials are summarized in this review...
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28918734/the-2016-royal-australian-and-new-zealand-college-of-psychiatrists-guidelines-for-the-management-of-schizophrenia-and-related-disorders
#6
David J Castle, Cherrie A Galletly, Frances Dark, Verity Humberstone, Vera A Morgan, Eóin Killackey, Jayashri Kulkarni, Patrick McGorry, Olav Nielssen, Nga T Tran, Assen Jablensky
The Royal Australian and New Zealand College of Psychiatrists (RANZCP) clinical practice guidelines for the management of schizophrenia and related disorders provide evidence-based recommendations for optimising treatment and prognosis. This update to the 2005 RANZCP guidelines has a greater emphasis on psychosocial treatments, physical health comorbidities and vocational rehabilitation. Main recommendations: The guidelines advise a clinical staging approach and deliver specific recommendations for:•comprehensive treatment using second generation antipsychotic agents continuously for 2-5 years;•early treatment of comorbid substance use;•community treatment after initial contact, during crises and after discharge from hospital;•physical health monitoring and management of comorbidities, particularly metabolic health;•interventions to optimise recovery of social function and return to study or work; and•management of schizophrenia in specific populations and circumstances...
June 19, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#7
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28914430/position-paper-recommendations-for-a-digital-mammography-quality-assurance-program%C3%A2-v4-0
#8
J C P Heggie, P Barnes, L Cartwright, J Diffey, J Tse, J Herley, I D McLean, F J Thomson, R K Grewal, L T Collins
In 2001 the ACPSEM published a position paper on quality assurance in screen film mammography which was subsequently adopted as a basis for the quality assurance programs of both the Royal Australian and New Zealand College of Radiologists (RANZCR) and of BreastScreen Australia. Since then the clinical implementation of digital mammography has been realised and it has become evident that existing screen-film protocols were not appropriate to assure the required image quality needed for reliable diagnosis or to address the new dose implications resulting from digital technology...
September 15, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28912002/living-systematic-review-1-introduction-the-why-what-when-and-how
#9
REVIEW
Julian H Elliott, Anneliese Synnot, Tari Turner, Mark Simmonds, Elie A Akl, Steve McDonald, Georgia Salanti, Joerg Meerpohl, Harriet MacLehose, John Hilton, David Tovey, Ian Shemilt, James Thomas
Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in review currency, accuracy, and utility. We are developing a novel approach to systematic review updating termed "Living systematic review" (LSR): systematic reviews that are continually updated, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields where research evidence is emerging rapidly, current evidence is uncertain, and new research may change policy or practice decisions...
September 11, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28911999/living-systematic-reviews-4-living-guideline-recommendations
#10
Elie A Akl, Joerg J Meerpohl, Julian Elliott, Lara A Kahale, Holger J Schünemann
While it is important for the evidence supporting practice guidelines to be current, that is often not the case. The advent of living systematic reviews has made the concept of "living guidelines" realistic, with the promise to provide timely, up-to-date and high quality guidance to target users. We define living guidelines as an optimization of the guideline development process to allow updating individual recommendations as soon as new relevant evidence becomes available. A major implication of that definition is that the unit of update is the individual recommendation, and not the whole guideline...
September 1, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28903874/mortality-in-danish-swine-herds-spatio-temporal-clusters-and-risk-factors
#11
Ana Carolina Lopes Antunes, Annette Kjær Ersbøll, Kristine Bihrmann, Nils Toft
The aim of this study was to explore spatio-temporal mortality patterns in Danish swine herds from December 2013 to October 2015, and to discuss the use of mortality data for syndromic surveillance in Denmark. Although it has previously been assessed within the context of syndromic surveillance, the value of mortality data generated on a regular and mandatory basis from all swine herds remains unexplored in terms of swine surveillance in Denmark. A total of 5010 farms were included in the analysis, corresponding to 1896 weaner herds, 1490 sow herds and 3839 finisher herds...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28901970/the-2016-who-classification-of-central-nervous-system-tumors-what-neurologists-need-to-know
#12
John C DeWitt, Andreas Mock, David N Louis
PURPOSE OF REVIEW: The 2016 WHO classification of tumors of the central nervous system (2016 CNS WHO) features many changes that are relevant to neurologists treating patients with brain tumors as well as neurologists involved in basic, clinical, and epidemiological research. This review summarizes what neurologists need to know and will need to know in the next years. RECENT FINDINGS: The 2016 CNS WHO introduces diagnostic terms that 'integrate' histological and molecular information and suggests presenting diagnoses in a four-layered reporting format...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28901726/antimicrobial-stewardship-in-paediatric-oncology-impact-on-optimising-gentamicin-use-in-febrile-neutropenia
#13
Stefanie Hennig, Christine E Staatz, Daniel Natanek, Sabina Bialkowski, Carolina Consuelo Llanos Paez, Rachael Lawson, Julia Clark
OBJECTIVES: To evaluate the impact of an antimicrobial stewardship (AMS) intervention, involving introduction of new guidelines on the treatment of febrile neutropenia (FN), on improving the use of gentamicin in paediatric oncology patients. DESIGN AND INTERVENTION: Updated guidelines for gentamicin usage in paediatrics with FN were implemented at a tertiary children's teaching hospital, in Brisbane, Australia. Data on gentamicin usage before and after the guideline change were collected retrospectively from children with cancer admitted to hospital with FN between January 2012 and December 2013...
September 13, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28881939/data-management-rubric-for-video-data-in-organismal-biology
#14
Elizabeth L Brainerd, Richard W Blob, Tyson L Hedrick, Andrew T Creamer, Ulrike K Müller
Standards-based data management facilitates data preservation, discoverability, and access for effective data reuse within research groups and across communities of researchers. Data sharing requires community consensus on standards for data management, such as storage and formats for digital data preservation, metadata (i.e., contextual data about the data) that should be recorded and stored, and data access. Video imaging is a valuable tool for measuring time-varying phenotypes in organismal biology, with particular application for research in functional morphology, comparative biomechanics, and animal behavior...
July 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28879313/developmental-procedures-for-the-clinical-practice-guidelines-for-conscious-sedation-in-dentistry-for-the-korean-academy-of-dental-sciences
#15
So-Youn An, Kwang-Suk Seo, Seungoh Kim, Jongbin Kim, Deok-Won Lee, Kyung-Gyun Hwang, Hyun Jeong Kim
BACKGROUND: Evidence-based clinical practice guidelines (CPGs) are defined as "statements that are scientifically reviewed about evidence and systematically developed to assist in the doctors' and patients' decision making in certain clinical situations." This recommendation aims to promote good clinical practice for the provision of safe and effective practices of conscious sedation in dentistry. METHODS: The development of this clinical practice guideline was conducted by performing a systematic search of the literature for evidence-based CPGs...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28873858/adaptive-sampling-technique-using-regression-modelling-and-fuzzy-inference-system-for-network-traffic
#16
Abdussalam Salama, Reza Saatchi, Derek Burke
Electronic-health relies on extensive computer networks to facilitate access and to communicate various types of information in the form of data packets. To examine the effectiveness of these networks, the traffic parameters need to be analysed. Due to quantity of packets, examining their transmission parameters individually is not practical, especially when performed in real time. Sampling allows a subset of packets that accurately represents the original traffic to be chosen. In this study an adaptive sampling method based on regression and fuzzy inference system was developed...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28873041/-booster-days-an-educational-initiative-to-develop-a-community-of-practice-of-primary-care-collaborative-memory-clinics
#17
Linda Lee, Loretta M Hillier, W Wayne Weston
This study explores the value of a Booster Day education initiative for clinicians working in interprofessional Primary Care Collaborative Memory Clinics (PCCMC) to share updates in dementia care, challenging cases, key lessons learned, and best practices, as a mechanism to foster learning and support the PCCMC Community of Practice (CoP). Between 2010 and 2016, 17 annual Booster Days were delivered to health professionals who completed the PCCMC training program. All participants were invited to complete an evaluation survey in which they identified the ways in which the sessions have been helpful; 89% (1361/1530) completed surveys...
September 5, 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/28865809/lifestyle-weight-management-programmes-for-children-a-systematic-review-using-qualitative-comparative-analysis-to-identify-critical-pathways-to-effectiveness
#18
REVIEW
Helen E D Burchett, Katy Sutcliffe, G J Melendez-Torres, Rebecca Rees, James Thomas
This study aimed to identify critical features of successful lifestyle weight management interventions for overweight children (0-11years). Eleven qualitative UK-based studies examining children's, parents' and providers' perspectives and experiences of programmes were synthesised to identify components felt to be critical. Studies for this views synthesis were identified from existing reviews and an update of one review's search, which was run in December 2015. The identified components were then explored in a synthesis of intervention evaluations (five 'most effective' and 15 'least effective') conducted in western Europe, North America, Australia or New Zealand...
August 30, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28858918/implementation-of-the-surviving-sepsis-campaign-guidelines
#19
Vikramjit Mukherjee, Laura Evans
PURPOSE OF REVIEW: Early identification and appropriate management of sepsis improves outcomes. Despite convincing data showing the benefits of early recognition and treatment of sepsis and septic shock, implementation of such evidence-based therapy is suboptimal. This review describes methods that have been shown to improve bedside application of the evidence-based guidelines. RECENT FINDINGS: The Surviving Sepsis Campaign (SSC) has developed guidelines for the management of severe sepsis and septic shock...
October 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28844044/the-antibiotic-management-of-gonorrhoea-in-ontario-canada-following-multiple-changes-in-guidelines-an-interrupted-time-series-analysis
#20
Catherine Dickson, Monica Taljaard, Dara Spatz Friedman, Gila Metz, Tom Wong, Jeremy M Grimshaw
OBJECTIVE: This study assessed adherence with first-line gonorrhoea treatment recommendations in Ontario, Canada, following recent guideline changes due to antibiotic resistance. METHODS: We used interrupted times-series analyses to analyse treatment data for cases of uncomplicated gonorrhoea reported in Ontario, Canada, between January 2006 and May 2014. We assessed adherence with first-line treatment according to the guidelines in place at the time and the use of specific antibiotics over time...
August 26, 2017: Sexually Transmitted Infections
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