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Sleep Spindles

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https://www.readbyqxmd.com/read/29325115/fast-sleep-spindle-density-is-associated-with-rs4680-val108-158met-genotype-of-catechol-o-methyltransferase-comt
#1
Claudia Schilling, Lena Gappa, Michael Schredl, Fabian Streit, Jens Treutlein, Josef Frank, Michael Deuschle, Andreas Meyer-Lindenberg, Marcella Rietschel, Stephanie H Witt
Study Objectives: Sleep spindles are a hallmark of NREM stage 2 sleep. Fast sleep spindles correlate with cognitive functioning, and are reduced in schizophrenia. Although spindles are highly genetically determined, distinct genetic mechanisms influencing sleep spindle activity have not been identified so far. Spindles are generated within a thalamo-cortical network. Dopaminergic neurotransmission modulates activity within this network and importantly depends on activity of catechol-O-methyltransferase (COMT)...
January 6, 2018: Sleep
https://www.readbyqxmd.com/read/29302203/a-novel-visualization-method-for-sleep-spindles-based-on-source-localization-of-high-density-eeg
#2
Soohyun Lee, Seunghwan Kim, Jee Hyun Choi
Equivalent dipole source localization is a well-established approach to localizing the electrical activity in electroencephalogram (EEG). So far, source localization has been used primarily in localizing the epileptic source in human epileptic patients. Currently, source localization techniques have been applied to account for localizing epileptic source among the epileptic patients. Here, we present the first application of source localization in the field of sleep spindle in mouse brain. The spatial distribution of cortical potential was obtained by high density EEG and then the anterior and posterior sleep spindles were classified based on the K-mean clustering algorithm...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29280209/sleep-spindles-and-slow-waves-in-schizophrenia-and-related-disorders-main-findings-challenges-and-future-perspectives
#3
Anna Castelnovo, Bianca Graziano, Fabio Ferrarelli, Armando D'Agostino
Sleep abnormalities have recently gained renewed attention in patients diagnosed with Schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase of studies related to sleep spindle and slow wave activity, findings remain in part contradictory. Although sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated Schizophrenia, data on the early stages of the disorder and in unmedicated subjects are still insufficient...
December 27, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29277652/transient-synchronization-of-hippocampo-striato-thalamo-cortical-networks-during-sleep-spindle-oscillations-induces-motor-memory-consolidation
#4
Arnaud Boutin, Basile Pinsard, Arnaud Boré, Julie Carrier, Stuart M Fogel, Julien Doyon
Sleep benefits motor memory consolidation. This mnemonic process is thought to be mediated by thalamo-cortical spindle activity during NREM-stage2 sleep episodes as well as changes in striatal and hippocampal activity. However, direct experimental evidence supporting the contribution of such sleep-dependent physiological mechanisms to motor memory consolidation in humans is lacking. In the present study, we combined EEG and fMRI sleep recordings following practice of a motor sequence learning (MSL) task to determine whether spindle oscillations support sleep-dependent motor memory consolidation by transiently synchronizing and coordinating specialized cortical and subcortical networks...
December 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/29273758/the-sleep-eeg-spectrum-is-a-sexually-dimorphic-marker-of-general-intelligence
#5
Péter P Ujma, Boris N Konrad, Ferenc Gombos, Péter Simor, Adrián Pótári, Lisa Genzel, Marcel Pawlowski, Axel Steiger, Róbert Bódizs, Martin Dresler
The shape of the EEG spectrum in sleep relies on genetic and anatomical factors and forms an individual "EEG fingerprint". Spectral components of EEG were shown to be connected to mental ability both in sleep and wakefulness. EEG sleep spindle correlates of intelligence, however, exhibit a sexual dimorphism, with a more pronounced association to intelligence in females than males. In a sample of 151 healthy individuals, we investigated how intelligence is related to spectral components of full-night sleep EEG, while controlling for the effects of age...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29249289/old-brains-come-uncoupled-in-sleep-slow-wave-spindle-synchrony-brain-atrophy-and-forgetting
#6
Randolph F Helfrich, Bryce A Mander, William J Jagust, Robert T Knight, Matthew P Walker
The coupled interaction between slow-wave oscillations and sleep spindles during non-rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation. However, little evidence in humans supports this theory. Moreover, whether such dynamic coupling is impaired as a consequence of brain aging in later life, contributing to cognitive and memory decline, is unknown. Combining electroencephalography (EEG), structural MRI, and sleep-dependent memory assessment, we addressed these questions in cognitively normal young and older adults...
December 12, 2017: Neuron
https://www.readbyqxmd.com/read/29234075/replay-of-large-scale-spatio-temporal-patterns-from-waking-during-subsequent-nrem-sleep-in-human-cortex
#7
Xi Jiang, Isaac Shamie, Werner K Doyle, Daniel Friedman, Patricia Dugan, Orrin Devinsky, Emad Eskandar, Sydney S Cash, Thomas Thesen, Eric Halgren
Animal studies support the hypothesis that in slow-wave sleep, replay of waking neocortical activity under hippocampal guidance leads to memory consolidation. However, no intracranial electrophysiological evidence for replay exists in humans. We identified consistent sequences of population firing peaks across widespread cortical regions during complete waking periods. The occurrence of these "Motifs" were compared between sleeps preceding the waking period ("Sleep-Pre") when the Motifs were identified, and those following ("Sleep-Post")...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29217404/high-density-eeg-characterization-of-brain-responses-to-auditory-rhythmic-stimuli-during-wakefulness-and-nrem-sleep
#8
Caroline Lustenberger, Yogi A Patel, Sankaraleengam Alagapan, Jessica M Page, Betsy Price, Michael R Boyle, Flavio Frohlich
Auditory rhythmic sensory stimulation modulates brain oscillations by increasing phase-locking to the temporal structure of the stimuli and by increasing the power of specific frequency bands, resulting in Auditory Steady State Responses (ASSR). The ASSR is altered in different diseases of the central nervous system such as schizophrenia. However, in order to use the ASSR as biological markers for disease states, it needs to be understood how different vigilance states and underlying brain activity affect the ASSR...
December 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29196666/sigma-frequency-dependent-motor-learning-in-williams-syndrome
#9
Andrea Berencsi, Róbert Bódizs, Ferenc Gombos, Szandra László, Ilona Kovács
There are two basic stages of fine motor learning: performance gain might occur during practice (online learning), and improvement might take place without any further practice (offline learning). Offline learning, also called consolidation, has a sleep-dependent stage in terms of both speed and accuracy of the learned movement. Sleep spindle or sigma band characteristics affect motor learning in typically developing individuals. Here we ask whether the earlier found, altered sigma activity in a neurodevelopmental disorder (Williams syndrome, WS) predicts motor learning...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180672/the-thalamic-reticular-nucleus-in-schizophrenia-and-bipolar-disorder-role-of-parvalbumin-expressing-neuron-networks-and-oxidative-stress
#10
P Steullet, J-H Cabungcal, S A Bukhari, M I Ardelt, H Pantazopoulos, F Hamati, T E Salt, M Cuenod, Kim Q Do, S Berretta
Growing evidence points to a disruption of cortico-thalamo-cortical circuits in schizophrenia (SZ) and bipolar disorder (BD). Clues for a specific involvement of the thalamic reticular nucleus (TRN) come from its unique neuronal characteristics and neural connectivity, allowing it to shape the thalamo-cortical information flow. A direct involvement of the TRN in SZ and BD has not been tested thus far. We used a combination of human postmortem and rodent studies to test the hypothesis that neurons expressing parvalbumin (PV neurons), a main TRN neuronal population, and associated Wisteria floribunda agglutinin-labeled perineuronal nets (WFA/PNNs) are altered in SZ and BD, and that these changes may occur early in the course of the disease as a consequence of oxidative stress...
November 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29175513/sleep-augments-training-induced-improvement-in-working-memory-in-children-and-adults
#11
Katharina Zinke, Hannes Noack, Jan Born
Sleep plays an important role in forming procedural motor memories. Whether sleep plays a similar role for cognitive procedures related to working memory function, is not yet clear. Here we investigated if sleep enhances training-induced improvements in working memory in children. Because children show more intense slow wave sleep (e.g., higher slow wave activity, more spindles) we expected sleep-related improvements to be greater than in adults. Twenty-four children (10-12 years) and 24 adults were trained on three sessions of an n-back task comprising three runs of blocks (6 blocks with 20 responses each) presented in ascending levels of difficulty...
November 22, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29170378/publisher-correction-cortical-dendritic-activity-correlates-with-spindle-rich-oscillations-during-sleep-in-rodents
#12
Julie Seibt, Clément J Richard, Johanna Sigl-Glöckner, Naoya Takahashi, David I Kaplan, Guy Doron, Denis de Limoges, Christina Bocklisch, Matthew E Larkum
In the originally published version of this Article, incorrect references were cited on two occasions in the Results section. Under the subheading 'Ca(2+) activity in single dendrites and somata of L5 neurons', the final sentence of the second paragraph incorrectly cited reference 29 instead of reference 31. Under the subheading 'Spiking of L5 cell bodies is not influenced by spindles', the first sentence cited reference 30 instead of reference 29. These errors have now been corrected in both the PDF and HTML versions of the Article...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29170000/sleep-disorder-and-altered-locomotor-activity-as-biomarkers-of-the-parkinson-s-disease-cholinopathy-in-rat
#13
Jelena Ciric, Katarina Lazic, Slobodan Kapor, Milka Perovic, Jelena Petrovic, Vesna Pesic, Selma Kanazir, Jasna Saponjic
In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the basal and stimulated locomotor activity. Sleep and basal locomotor activity in adult Wistar rats were followed during their inactive circadian phase, and throughout the same aging period. The bilateral PPT lesions were done by 0...
November 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29157588/sleep-spindles-may-predict-response-to-cognitive-behavioral-therapy-for-chronic-insomnia
#14
Thien Thanh Dang-Vu, Benjamin Hatch, Ali Salimi, Melodee Mograss, Soufiane Boucetta, Jordan O'Byrne, Marie Brandewinder, Christian Berthomier, Jean-Philippe Gouin
BACKGROUND: While cognitive-behavioral therapy for insomnia constitutes the first-line treatment for chronic insomnia, only few reports have investigated how sleep architecture relates to response to this treatment. In this pilot study, we aimed to determine whether pre-treatment sleep spindle density predicts treatment response to cognitive-behavioral therapy for insomnia. METHODS: Twenty-four participants with chronic primary insomnia participated in a 6-week cognitive-behavioral therapy for insomnia performed in groups of 4-6 participants...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29133062/anatomical-and-physiological-basis-of-continuous-spike-wave-of-sleep-syndrome-after-early-thalamic-lesions
#15
Alberto Leal, Eulália Calado, José P Vieira, Carla Mendonça, José C Ferreira, Hugo Ferreira, Daniel Carvalho, Fátima Furtado, Roseli Gomes, José P Monteiro
OBJECTIVE: Early neonatal thalamic lesions account for about 14% of continuous spike-wave of sleep (CSWS) syndrome, representing the most common etiology in this epileptic encephalopathy in children, and promise useful insights into the pathophysiology of the disease. METHODS: We describe nine patients with unilateral neonatal thalamic lesions which progressed to CSWS. Longitudinal whole-night and high-density electroencephalograms (EEGs) were performed, as well as detailed imaging and clinical evaluation...
November 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29118106/sleep-in-humans-stabilizes-pattern-separation-performance
#16
A Hanert, F D Weber, A Pedersen, J Born, T Bartsch
Replay of hippocampal neural representations during sleep is thought to promote systems consolidation of declarative memory. How this reprocessing of memory during sleep affects the hippocampal representation itself, is unclear. Here we tested hippocampal stimulus processing, i.e., pattern separation, before and after periods of sleep and wakefulness in humans (female and male participants). Pattern separation deteriorated across the wake period but remained stable across sleep (p = .013) with this sleep-wake difference being most pronounced for stimuli with low similarity to targets (p = ...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29109037/lateralised-sleep-spindles-relate-to-false-memory-generation
#17
John J Shaw, Padraic Monaghan
Sleep is known to enhance false memories: After presenting participants with lists of semantically related words, sleeping before recalling these words results in a greater acceptance of unseen "lure" words related in theme to previously seen words. Furthermore, the right hemisphere (RH) seems to be more prone to false memories than the left hemisphere (LH). In the current study, we investigated the sleep architecture associated with these false memory and lateralisation effects in a nap study. Participants viewed lists of related words, then stayed awake or slept for approximately 90min, and were then tested for recognition of previously seen-old, unseen-new, or unseen-lure words presented either to the LH or RH...
November 3, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29101344/dynamic-coupling-between-slow-waves-and-sleep-spindles-during-slow-wave-sleep-in-humans-is-modulated-by-functional-pre-sleep-activation
#18
Juliana Yordanova, Roumen Kirov, Rolf Verleger, Vasil Kolev
Co-existent sleep spindles and slow waves have been viewed as a mechanism for offline information processing. Here we explored if the temporal synchronization between slow waves and spindle activity during slow wave sleep (SWS) in humans was modulated by preceding functional activations during pre-sleep learning. We activated differentially the left and right hemisphere before sleep by using a lateralized variant of serial response time task (SRTT) and verified these inter-hemispheric differences by analysing alpha and beta electroencephalographic (EEG) activities during learning...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097698/circadian-preference-towards-morningness-is-associated-with-lower-slow-sleep-spindle-amplitude-and-intensity-in-adolescents
#19
Ilona Merikanto, Liisa Kuula, Tommi Makkonen, Róbert Bódizs, Risto Halonen, Kati Heinonen, Jari Lahti, Katri Räikkönen, Anu-Katriina Pesonen
Individual circadian preference types and sleep EEG patterns related to spindle characteristics, have both been associated with similar cognitive and mental health phenotypes. However, no previous study has examined whether sleep spindles would differ by circadian preference. Here, we explore if spindle amplitude, density, duration or intensity differ by circadian preference and whether these associations are moderated by spindle location, frequency, and time distribution across the night. The participants (N = 170, 59% girls; mean age = 16...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095855/impaired-memory-consolidation-in-children-with-obstructive-sleep-disordered-breathing
#20
Kiran Maski, Erin Steinhart, Hannah Holbrook, Eliot S Katz, Kush Kapur, Robert Stickgold
Memory consolidation is stabilized and even enhanced by sleep (and particularly by 12-15 Hz sleep spindles in NREM stage 2 sleep) in healthy children but it is unclear what happens to these processes when sleep is disturbed by obstructive sleep disordered breathing. This cross-sectional study investigates differences in declarative memory consolidation among children with primary snoring (PS) and obstructive sleep apnea (OSA) compared to controls. We further investigate whether memory consolidation group differences are associated with NREM stage 2 (N2) sigma (12-15 Hz) or NREM slow oscillation (0...
2017: PloS One
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