Vladislav V Minaychev, Polina V Smirnova, Margarita I Kobyakova, Anastasia Yu Teterina, Igor V Smirnov, Vladimir D Skirda, Artem S Alexandrov, Marat R Gafurov, Mikhail A Shlykov, Kira V Pyatina, Anatoliy S Senotov, Pavel S Salynkin, Roman S Fadeev, Vladimir S Komlev, Irina S Fadeeva
Creating bioactive materials for bone tissue regeneration and augmentation remains a pertinent challenge. One of the most promising and rapidly advancing approaches involves the use of low-temperature ceramics that closely mimic the natural composition of the extracellular matrix of native bone tissue, such as Hydroxyapatite (HAp) and its phase precursors (Dicalcium Phosphate Dihydrate-DCPD, Octacalcium Phosphate-OCP, etc.). However, despite significant scientific interest, the current knowledge and understanding remain limited regarding the impact of these ceramics not only on reparative histogenesis processes but also on the immunostimulation and initiation of local aseptic inflammation leading to material rejection...
January 24, 2024: Biomedicines