Jia-Bo Wang, He-Rong Cui, Rui-Lin Wang, Cong-En Zhang, Ming Niu, Zhao-Fang Bai, Gen-Hua Xu, Peng-Yan Li, Wen-Yan Jiang, Jing-Jing Han, Xiao Ma, Guang-Ming Cai, Rui-Sheng Li, Li-Ping Zhang, Xiao-He Xiao
Multiple components of traditional Chinese medicine (TCM) formulae determine their treatment targets for multiple diseases as opposed to a particular disease. However, discovering the unexplored therapeutic potential of a TCM formula remains challenging and costly. Inspired by the drug repositioning methodology, we propose an integrated strategy to feasibly identify new therapeutic uses for a formula composed of six herbs, Liuweiwuling. First, we developed a comprehensive systems approach to enrich drug compound-liver disease networks to analyse the major predicted diseases of Liuweiwuling and discover its potential effect on liver failure...
April 4, 2018: Scientific Reports