keyword
MENU ▼
Read by QxMD icon Read
search

Joel

keyword
https://www.readbyqxmd.com/read/29334121/the-multipotency-to-commitment-transition-mct-in-c-elegans-implications-for-reprogramming-from-cells-to-organs
#1
REVIEW
Erik A Spickard, Pradeep M Joshi, Joel H Rothman
In animal embryos, cells transition from a multipotential state, with the capacity to adopt multiple fates, into an irreversible, committed state of differentiation. This multipotency-to-commitment transition (MCT) is evident from experiments in which cell fate is reprogrammed by transcription factors for cell-type-specific differentiation, as has been observed extensively in C. elegans. Although factors that direct differentiation into each of the three germ layer types cannot generally reprogram cells after the MCT in this animal, transcription factors for endoderm development are able to do so in multiple differentiated cell types...
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29333473/charge-migration-and-charge-transfer-in-molecular-systems
#2
REVIEW
Hans Jakob Wörner, Christopher A Arrell, Natalie Banerji, Andrea Cannizzo, Majed Chergui, Akshaya K Das, Peter Hamm, Ursula Keller, Peter M Kraus, Elisa Liberatore, Pablo Lopez-Tarifa, Matteo Lucchini, Markus Meuwly, Chris Milne, Jacques-E Moser, Ursula Rothlisberger, Grigory Smolentsev, Joël Teuscher, Jeroen A van Bokhoven, Oliver Wenger
The transfer of charge at the molecular level plays a fundamental role in many areas of chemistry, physics, biology and materials science. Today, more than 60 years after the seminal work of R. A. Marcus, charge transfer is still a very active field of research. An important recent impetus comes from the ability to resolve ever faster temporal events, down to the attosecond time scale. Such a high temporal resolution now offers the possibility to unravel the most elementary quantum dynamics of both electrons and nuclei that participate in the complex process of charge transfer...
November 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/29332686/no-evidence-for-an-epidemiological-transition-in-sleep-patterns-among-children-a-12-country-study
#3
Taru Manyanga, Joel D Barnes, Mark S Tremblay, Peter T Katzmarzyk, Stephanie T Broyles, Tiago V Barreira, Mikael Fogelholm, Gang Hu, Carol Maher, Jose Maia, Timothy Olds, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Jean-Philippe Chaput
OBJECTIVE: To examine the relationships between socioeconomic status (SES; household income and parental education) and objectively measured sleep patterns (sleep duration, sleep efficiency, and bedtime) among children from around the world and explore how the relationships differ across country levels of human development. DESIGN: Multinational, cross-sectional study from sites in Australia, Brazil, Canada, China, Colombia, Finland, India, Kenya, Portugal, South Africa, the United Kingdom, and the United States...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29331546/clinically-localized-prostate-cancer-aua-astro-suo-guideline-part-ii-recommended-approaches-and-details-of-specific-care-options
#4
Martin G Sanda, Jeffrey A Cadeddu, Erin Kirkby, Ronald C Chen, Tony Crispino, Joann Fontanarosa, Stephen J Freedland, Kirsten Greene, Laurence H Klotz, Danil V Makarov, Joel B Nelson, George Rodrigues, Howard M Sandler, Mary Ellen Taplin, Jonathan R Treadwell
PURPOSE: This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented herein represents Part II of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. Please refer to Part I for discussion of specific care options and outcome expectations and management...
January 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29330886/surgery-and-magnetic-resonance-imaging-increase-the-risk-of-hypothermia-in-infants
#5
Joel M Don Paul, Elizabeth J Perkins, Prue M Pereira-Fantini, Asha Suka, Olivia Farrell, Julia K Gunn, Anushi E Rajapaksa, David G Tingay
AIM: Maintaining normothermia is a tenet of neonatal care. However, neonatal thermal care guidelines applicable to intra-hospital transport beyond the neonatal intensive care unit (NICU) and during surgery or magnetic resonance imaging (MRI) are lacking. The aim of this study is to determine the proportion of infants normothermic (36.5-37.5°C) on return to NICU after management during surgery and MRI, and during standard clinical care in both environments. METHODS: Sixty-two newborns requiring either surgery in the operating theatre (OT) (n = 41) or an MRI scan (n = 21) at the Royal Children's Hospital (Melbourne) NICU were prospectively studied...
January 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29330118/using-the-ribodeblur-pipeline-to-recover-a-sites-from-yeast-ribosome-profiling-data
#6
Hao Wang, Carl Kingsford, C Joel McManus
Ribosome profiling has emerged as a powerful technique to study mRNA translation. Ribosome profiling has the potential to determine the relative quantities and locations of ribosomes on mRNA genome wide. Taking full advantage of this approach requires accurate measurement of ribosome locations. However, experimental inconsistencies often obscure the positional information encoded in ribosome profiling data. Here, we describe the Ribodeblur pipeline, a computational analysis tool that uses a maximum likelihood framework to infer ribosome positions from heterogeneous datasets...
January 9, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29329579/prevalence-and-incidence-of-major-depressive-disorders-among-people-living-with-hiv-residing-in-africa-a-systematic-review-and-meta-analysis-protocol
#7
Jean Joel Bigna, Lewis N Um, Serra Lem Asangbeh, Aurelie T Sibetcheu, Arnaud D Kazé, Jobert Richie Nansseu
BACKGROUND: Depression represents one of the most frequent neuro-psychiatric diseases; it seems to be more prevalent in people living with HIV compared to the general population. However, summarized data in the African setting on the topic are scarce. This systematic review and meta-analysis aims at assessing the prevalence and incidence of major depressive disorders (MDD) in HIV-infected African populations residing in Africa. METHODS AND DESIGN: This review will include observational studies conducted among HIV-infected people residing in Africa, which have reported either the prevalence or incidence of MDD or enough data for its appraisal...
January 12, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29329557/one-year-risk-of-serious-infection-in-patients-treated-with-certolizumab-pegol-as-compared-with-other-tnf-inhibitors-in-a-real-world-setting-data-from-a-national-u-s-rheumatoid-arthritis-registry
#8
Leslie R Harrold, Heather J Litman, Katherine C Saunders, Kimberly J Dandreo, Bernice Gershenson, Jeffrey D Greenberg, Robert Low, Jeffrey Stark, Robert Suruki, Srihari Jaganathan, Joel M Kremer, Mohamed Yassine
BACKGROUND: Registry studies provide a valuable source of comparative safety data for tumor necrosis factor inhibitors (TNFi) used in rheumatoid arthritis (RA), but they are subject to channeling bias. Comparing safety outcomes without accounting for channeling bias can lead to inaccurate comparisons between TNFi prescribed at different stages of the disease. In the present study, we examined the incidence of serious infection and other adverse events during certolizumab pegol (CZP) use vs other TNFi in a U...
January 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29329299/multi-drug-resistant-non-typhoidal-salmonella-associated-with-invasive-disease-in-western-kenya
#9
Adam Akullian, Joel M Montgomery, Grace John-Stewart, Samuel I Miller, Hillary S Hayden, Matthew C Radey, Kyle R Hager, Jennifer R Verani, John Benjamin Ochieng, Jane Juma, Jim Katieno, Barry Fields, Godfrey Bigogo, Allan Audi, Judd Walson
Non-typhoidal Salmonella (NTS) is a leading cause of bloodstream infections in Africa, but the various contributions of host susceptibility versus unique pathogen virulence factors are unclear. We used data from a population-based surveillance platform (population ~25,000) between 2007-2014 and NTS genome-sequencing to compare host and pathogen-specific factors between individuals presenting with NTS bacteremia and those presenting with NTS diarrhea. Salmonella Typhimurium ST313 and Salmonella Enteritidis ST11 were the most common isolates...
January 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29328704/short-range-correlations-and-the-emc-effect-in-effective-field-theory
#10
Jiunn-Wei Chen, William Detmold, Joel E Lynn, Achim Schwenk
We show that the empirical linear relation between the magnitude of the EMC effect in deep inelastic scattering on nuclei and the short-range correlation scaling factor a_{2} extracted from high-energy quasielastic scattering at x≥1 is a natural consequence of scale separation and derive the relationship using effective field theory. While the scaling factor a_{2} is a ratio of nuclear matrix elements that individually depend on the calculational scheme, we show that the ratio is independent of this choice...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328674/new-insights-on-ecosystem-mercury-cycling-revealed-by-stable-isotopes-of-mercury-in-water-flowing-from-a-headwater-peatland-catchment
#11
Glenn Woerndle, Martin Tsz-Ki Tsui, Stephen Sebestyen, Joel D Blum, Xiangping Nie, Randall K Kolka
Stable isotope compositions of mercury (Hg) were measured in the outlet stream and in soil cores at different landscape positions in a 9.7-ha boreal upland-peatland catchment in northern Minnesota. An acidic permanganate/persulfate digestion procedure was validated for water samples with high dissolved organic matter (DOM) concentrations and we verified the complete breakdown of DOM through Hg spike addition analysis. We report a relatively large variation in mass-dependent fractionation (δ202Hg; from -2.12 to -1...
January 12, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29328634/exploring-the-rich-potential-energy-surface-of-h2o-11-and-its-physical-implications
#12
Berhane Temelso, Katurah L Klein, Joel W Mabey, Cristóbal Pérez, Brooks H Pate, Zbigniew Kisiel, George C Shields
The rich potential energy surface of the water undecamer, (H2O)11, was explored with a basin-hopping algorithm using a TIP4P potential followed by extensive ab initio MP2 minimizations and CCSD(T) corrections. This protocol yielded 17, 66, and 125 distinct isomers within 0.5, 1.0 and 2.0 kcal mol-1 of the complete basis set CCSD(T) global minimum, respectively. These isomers were categorized into fifteen different families based on their oxygen framework and hydrogen bonding topology. Determination of the global minimum proved challenging because of the presence of many nearly isoenergetic isomers...
January 12, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29328535/an-exceptionally-close-non-bonded-hydrogen-hydrogen-contact-with-strong-through-space-spin-spin-coupling
#13
Yonglong Xiao, Joel T Mague, Robert A Pascal
Condensation of 1,8,13-tris(mercaptomethyl)triptycene and tris(bromomethyl)methane yields an in,in-cyclophane with two inwardly directed methine groups. Based on X-ray analysis and DFT and MP2 calculations, the hydrogen-hydrogen non-bonded contact distance is estimated to be 1.50-1.53 Å. In addition, the two in-hydrogen atoms show obvious spin-spin coupling with J = 2.0 Hz.
January 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29326315/plasma-n-3-and-n-6-fatty-acids-are-differentially-related-to-carotid-plaque-and-its-progression-mesa-the-multi-ethnic-study-of-atherosclerosis
#14
Brian T Steffen, Weihua Guan, James H Stein, Mathew C Tattersall, Joel D Kaufman, Veit Sandfort, Moyses Szklo, Michael Y Tsai
OBJECTIVE: ω-3 (n-3) fatty acids (FAs) have long been considered healthful dietary components, yet recent clinical trials have questioned their cardiovascular benefits. By contrast, the ω-6 (n-6) FAs have been considered harmful, proatherogenic macronutrients, despite an absence of empirical evidence supporting this hypothesis. We aimed to determine whether plasma n-3 and n-6 FAs are related to risk of carotid plaque and its progression in 3327 participants of the MESA (Multi-Ethnic Study of Atherosclerosis)...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326211/draft-whole-genome-sequence-of-deinococcus-sp-ur1-a-putative-novel-species-isolated-from-an-external-stainless-steel-surface-in-the-canadian-prairies
#15
Danae M Suchan, Joel J Steve, Alexa J Pierce, Stephen C Olshefsky, Morgan W B Kirzinger, Benjamin J Perry, Andrew D S Cameron, Christopher K Yost
Deinococcus sp. strain UR1, a resilient bacterium isolated from the surface of a stainless steel sign located on the University of Regina campus in Saskatchewan, Canada, was sequenced to 56-fold coverage to produce 73 contigs with a consensus length of 4,472,838 bp and a G+C content of 69.37%.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325776/prevalence-of-prediabetes-and-diabetes-mellitus-among-adults-residing-in-cameroon-a-systematic-review-and-meta-analysis
#16
REVIEW
Jean Joel Bigna, Jobert Richie Nansseu, Jean-Claude Katte, Jean Jacques Noubiap
AIMS: To summarize current data on the prevalence of prediabetes and diabetes mellitus in Cameroon. METHODS: Population-based cross-sectional studies published between January 1, 2000 and April 30, 2017 including apparently healthy adults residing in Cameroon were searched in PubMed, EMBASE, African Journals Online, and African Index Medicus. We used a random-effects model to pool data. RESULTS: All included studies had a low risk of bias...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325760/nephmadness-after-5-years-a-recap-and-game-plan-for-the-future
#17
EDITORIAL
Matthew A Sparks, Joel M Topf
No abstract text is available yet for this article.
January 4, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29325454/down-expression-of-p2rx2-kcnq5-erbb3-and-socs3-through-dna-hypermethylation-in-elderly-women-with-presbycusis
#18
Amal Bouzid, Ibtihel Smeti, Leila Dhouib, Magali Roche, Imen Achour, Aida Khalfallah, Abdullah Ahmed Gibriel, Ilhem Charfeddine, Hammadi Ayadi, Joel Lachuer, Abdelmonem Ghorbel, Christine Petit, Saber Masmoudi
CONTEXT: Presbycusis, an age-related hearing impairment (ARHI), represents the most common sensory disability in adults. Today, the molecular mechanisms underlying presbycusis remain unclear. This is in particular due to the fact that ARHI is a multifactorial complex disorder resulting from several genomic factors interacting with lifelong cumulative effects of: disease, diet, and environment. OBJECTIVE: Identification of novel biomarkers for presbycusis. MATERIALS AND METHODS: We selectively ascertained eighteen elderly unrelated women lacking environmental and metabolic risk factors...
January 11, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29325415/recrystallization-of-manganite-%C3%AE-mnooh-and-implications-for-trace-element-cycling
#19
Tobias Hens, Joël Brugger, Susan Cumberland, Barbara Etschmann, Andrew J Frierdich
The recrystallization of Mn(III,IV) oxides is catalyzed by aqueous Mn(II) (Mn(II)aq) during (bio)geochemical Mn redox cycling. It is poorly understood how trace metals associated with Mn oxides (e.g., Ni) are cycled during such recrystallization. Here, we use X-ray absorption spectroscopy (XAS) to examine the speciation of Ni associated with manganite (γ-Mn(III)OOH) suspensions in the presence or absence of Mn(II)aq under variable pH conditions (pH 5.5 and 7.5). In a second set of experiments, we used a 62Ni isotope tracer to quantify the amount of dissolved Ni that exchanges with Ni incorporated in the manganite crystal structure during reactions in 1 mM Mn(II)aq and in Mn(II)-free solutions...
January 11, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29325036/evaluation-of-left-atrial-linear-ablation-using-contiguous-and-optimized-radiofrequency-lesions-the-aline-study
#20
Michael Wolf, Milad El Haddad, Joël Fedida, Philippe Taghji, Katarina Van Beeumen, Teresa Strisciuglio, Jan De Pooter, Caroline Lepièce, Yves Vandekerckhove, René Tavernier, Mattias Duytschaever, Sébastien Knecht
Aims: Achieving block across linear lesions is challenging. We prospectively evaluated radiofrequency (RF) linear ablation at the roof and mitral isthmus (MI) using point-by-point contiguous and optimized RF lesions. Methods and results: Forty-one consecutive patients with symptomatic persistent AF underwent stepwise contact force (CF)-guided catheter ablation during ongoing AF. A single linear set of RF lesions was delivered at the roof and posterior MI according to the 'Atrial LINEar' (ALINE) criteria, i...
January 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
keyword
keyword
61530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"