Avril K Coley, Chenyue Lu, Amaya Pankaj, Matthew J Emmett, Evan R Lang, Yuhui Song, Katherine H Xu, Nova Xu, Bidish K Patel, Abhijit Chougule, Linda T Nieman, Martin J Aryee, Cristina R Ferrone, Vikram Deshpande, Joseph W Franses, David T Ting
PURPOSE: Dysregulation of viral-like repeat RNAs are a common feature across many malignancies that are linked with immunological response, but the characterization of these in hepatocellular carcinoma (HCC) is understudied. In this study, we performed RNA in situ hybridization (RNA-ISH) of different repeat RNAs, immunohistochemistry (IHC) for immune cell subpopulations, and spatial transcriptomics to understand the relationship of HCC repeat expression, immune response, and clinical outcomes...
December 5, 2023: bioRxiv