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https://www.readbyqxmd.com/read/29148821/the-effect-of-prior-continuous-glucose-monitoring-use-on-glycemic-outcomes-in-the-pivotal-trial-of-the-minimed-%C3%A2-670g-hybrid-closed-loop-system
#1
Toni L Cordero, Satish K Garg, Ronald Brazg, Timothy S Bailey, John Shin, Scott W Lee, Francine R Kaufman
A 3-month pivotal trial using the MiniMed™ 670G hybrid closed-loop (HCL) system in adolescent and adult patients with type 1 diabetes (T1D), relative to a 2-week baseline run-in period, resulted in increased sensor glucose (SG) values in target range (71-180 mg/dL), reduced HbA1c levels, and no events of diabetic ketoacidosis or severe hypoglycemia ( Clinicaltrials.gov : NCT02463097). This brief report evaluated how prior continuous glucose monitoring (CGM) experience influenced glycemic outcomes, in the same pivotal trial...
November 17, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29141460/safety-and-efficacy-of-metformin-up-titration-in-japanese-patients-with-type-2-diabetes-mellitus-treated-with-vildagliptin-and-low-dose-metformin
#2
Luka Suzuki, Akio Kanazawa, Hirotsugu Uzawa, Yusuke Osonoi, Atushi Masuyama, Kosuke Azuma, Kageumi Takeno, Naoko Takayanagi, Junko Sato, Yuki Someya, Koji Komiya, Hiromasa Goto, Tomoya Mita, Fuki Ikeda, Takeshi Ogihara, Tomoaki Shimizu, Chie Ohmura, Miyoko Saito, Takeshi Osonoi, Hirotaka Watada
BACKGROUND: This study investigated the safety and efficacy of metformin up-titration in Japanese patients with type 2 diabetes mellitus treated with vildagliptin (100 mg/day) and low-dose metformin (500 or 750 mg/day). RESEARCH DESIGN AND METHODS: Fifty patients were randomly allocated to the control group (maintaining the initial low-dose of metformin) and the dose increase group (up-titrating of metformin to 1,500-2,250 mg/day) for 24 weeks. The primary outcome was change in HbA1c from baseline to 24 weeks...
November 15, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29133220/effects-of-exercise-and-diet-in-nonobese-asthma-patients-a-randomized-controlled-trial
#3
Louise Lindhardt Toennesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjoern Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer
BACKGROUND: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. OBJECTIVES: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29130716/-effect-of-quinua-chenopodium-quinoa-consumption-as-a-coadjuvant-in-nutritional-intervention-in-prediabetic-subjects
#4
María Salud Abellán Ruiz, María Dolores Barnuevo Espinosa, Carlos García Santamaría, Carlos Javier Contreras Fernández, Miriam Aldeguer García, Fulgencio Soto Méndez, Isabel Guillén Guillén, Antonio Jesús Luque Rubia, Francisco Javier Quinde Ràzuri, Antonio Martínez Garrido, Francisco Javier López Román
INTRODUCTION: Quinoa is a pseudocereal containing low glycemic index carbohydrates, dietary fiber, high biological value protein, phytosterols, and n-3 and n-6 fatty acids, which has generated interest in prediabetes nutritional interventions. This randomized (2:1), placebo-controlled, double-blind study evaluated the effects of processed quinoa on body mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and the satiation and fullness (complete) degree in prediabetic patients...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29129980/quality-of-care-of-patients-with-diabetes-in-primary-health-services-in-southeast-brazil
#5
Christiane Chaves Augusto Leite Simão, Mônica Barros Costa, Fernando Antônio Basile Colugnati, Elaine Amaral de Paula, Chislene Pereira Vanelli, Rogério Baumgratz de Paula
Background: Diabetes management involves multiple aspects that go beyond drug therapy as a way of providing high quality care. The objective of this study was to describe quality of care indicators for individuals with diabetes in southeast Brazil and to explore associations among these indicators. Methods: In this cross-sectional, observational study, health care providers filled out a questionnaire addressing health care structure and processes at 14 primary health care units (PHCUs)...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/29128103/the-benefits-of-a-low-dose-complex-carbohydrate-citrulline-electrolyte-solution-for-preoperative-carbohydrate-loading-focus-on-glycemic-variability
#6
Barrett A Kielhorn, Anthony J Senagore, Theodor Asgeirsson
BACKGROUND: Perioperative insulin resistance is associated with significant hyperglycemia-related morbidity in patients undergoing major surgery. We sought to assess the effect of preoperative loading with a low-dose maltodextrin/citrulline solution compared to a commercially available sports drink on glycemic levels in an established colorectal enhanced recovery program. METHODS: Retrospective analysis was undertaken of elective non-diabetic colectomies and enterectomies from January 2016-March 2017...
November 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29125537/associations-of-fasting-blood-glucose-with-influencing-factors-in-northeast-china-a-quantile-regression-analysis
#7
Xin Guo, Li Shen, Jing Dou, Yaogai Lv, Anning Zhang, Fanchao Shi, Zhiqiang Xue, Yaqin Yu, Lina Jin, Yan Yao
Background: Diabetes mellitus (DM) has become a major public health problem in China. Although a number of researchers have investigated DM risk factors, little is known about the associations between values of fasting blood glucose (FBG) and influencing factors. This study aims to explore these associations by the quantile regression (QR) model. Methods: A cross-sectional survey based on a sample of 23,050 adults aged 18 to 79 years was conducted in Jilin in 2012, and some subjects were excluded due to missing values with respect to necessary variables or having glycemic control, in accordance with the purposes of this study...
November 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29121408/community-health-workers-supporting-clinical-pharmacists-in-diabetes-management-a-randomized-controlled-trial
#8
Lisa K Sharp, Jessica J Tilton, Daniel R Touchette, Yinglin Xia, Daniel Mihailescu, Michael L Berbaum, Ben S Gerber
OBJECTIVES: To evaluate the effectiveness of clinical pharmacists and community health workers (CHWs) in improving glycemic control within a low-income, ethnic minority population. METHODS: In a two-arm, 2-year, crossover trial, 179 African-American and 65 Hispanic adult patients with uncontrolled diabetes mellitus (hemoglobin A1c [HbA1c] ≥ 8%) were randomized to CHW support either during the first or second year of the study. All participants received clinical pharmacist support for both years of the study...
November 9, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29116584/use-of-50-50-premixed-insulin-analogs-in-type-2-diabetes-systematic-review-and-clinical-recommendations
#9
REVIEW
Gary Deed, Gary Kilov, Trisha Dunning, Richard Cutfield, Jane Overland, Ted Wu
INTRODUCTION: Premixed insulin analogs represent an alternative to basal or basal-bolus insulin regimens for the treatment of type 2 diabetes (T2D). "Low-mix" formulations with a low rapid-acting to long-acting analog ratio (e.g., 25/75) are commonly used, but 50/50 formulations (Mix50) may be more appropriate for some patients. We conducted a systematic literature review to assess the efficacy and safety of Mix50, compared with low-mix, basal, or basal-bolus therapy, for insulin initiation and intensification...
December 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29110406/switching-from-low-dose-thiazide-diuretics-to-sglt2-inhibitor-improves-various-metabolic-parameters-without-affecting-blood-pressure-in-subjects-with-type-2-diabetes-and-hypertension
#10
Tomohiko Kimura, Junpei Sanada, Masashi Shimoda, Hidenori Hirukawa, Yoshiro Fushimi, Momoyo Nishioka, Tomoe Kinoshita, Seizo Okauchi, Atsushi Obata, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIM/INTRODUCTION: Sodium-glucose co-transporter 2 (SGLT2) inhibitors function to increase urinary glucose excretion and improve glycemic control in subjects with type 2 diabetes mellitus. SGLT2 inhibitors as well as diuretics increase urinary volume which leads to the reduction of blood pressure. The aim of this study was to compare the effects of SGLT2 inhibitor and thiazide diuretic on blood pressure, metabolic parameters and body mass composition. MATERIALS AND METHODS: A total of 31 subjects were enrolled in this study...
November 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29109662/budget-impact-of-introducing-linagliptin-into-bosnia-and-herzegovina-health-insurance-drug-reimbursement-list-in-2016-2018
#11
Tarik Catic, Lana Lekic, Vlad Zah, Vedad Tabakovic
Introduction: Diabetes is reaching epidemiological scales worldwide. Beside health implications diabetes bears significant financial impact on health systems. Different treatment options aiming to prevent diabetes complications are available. Dipeptidyl-peptidase-IV (DPP-4) inhibitors like linagliptin are usually add-on therapy to metformin in order to achieve glycemic control. Expenditure for oral antidiabetic medicines in Bosnia and Herzegovina (B&H) is low accounting for only 2.53% of the total drug market expenditure...
September 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29107291/absence-of-the-kinase-s6k1-mimics-the-effect-of-chronic-endurance-exercise-on-glucose-tolerance-and-muscle-oxidative-stress
#12
C Binsch, T Jelenik, A Pfitzer, M Dille, S Müller-Lühlhoff, S Hartwig, S Karpinski, S Lehr, D G Kabra, A Chadt, M Roden, H Al-Hasani, T R Castañeda
OBJECTIVE: Ribosomal protein S6 Kinase-1 (S6K1) has been linked to resistance exercise-mediated improvements in glycemia. We hypothesized that S6K1 may also play a role in regulating glycemic control in response to endurance exercise training. METHODS: S6k1-knockout (S6K1KO) and WT mice on a 60 cal% high-fat diet were trained for 4 weeks on treadmills, metabolically phenotyped, and compared to sedentary controls. RESULTS: WT mice showed improved glucose tolerance after training...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29106816/insulin-glargine-300-u-ml-is-associated-with-less-weight-gain-while-maintaining-glycemic-control-and-low-risk-of-hypoglycemia-compared-with-insulin-glargine-100-u-ml-in-an-aging-population-with-type-2-diabetes
#13
Medha N Munshi, Jasvinder Gill, Jason Chao, Elena V Nikonova, Meenakshi Patel
OBJECTIVE: Assess efficacy, hypoglycemia and weight gain in patients with type 2 diabetes (T2D) treated with insulin glargine 300 U/mL (Gla-300) or 100 U/mL (Gla-100) across different age groups. METHODS: Pooled data were generated for patients randomized to Gla-300 or Gla-100 in the EDITION 2 (NCT01499095) and 3 (NCT01676220) studies. In four age groups (<55, ≥55 to <60, ≥60 to <65, ≥65 years), glycated hemoglobin A1C (A1C), percentage of patients reaching A1C <7...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29106398/asprosin-is-a-centrally-acting-orexigenic-hormone
#14
Clemens Duerrschmid, Yanlin He, Chunmei Wang, Chia Li, Juan C Bournat, Chase Romere, Pradip K Saha, Mark E Lee, Kevin J Phillips, Mahim Jain, Peilin Jia, Zhongming Zhao, Monica Farias, Qi Wu, Dianna M Milewicz, V Reid Sutton, David D Moore, Nancy F Butte, Michael J Krashes, Yong Xu, Atul R Chopra
Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose production. Here we demonstrate that asprosin in the circulation crosses the blood-brain barrier and directly activates orexigenic AgRP(+) neurons via a cAMP-dependent pathway. This signaling results in inhibition of downstream anorexigenic proopiomelanocortin (POMC)-positive neurons in a GABA-dependent manner, which then leads to appetite stimulation and a drive to accumulate adiposity and body weight. In humans, a genetic deficiency in asprosin causes a syndrome characterized by low appetite and extreme leanness; this is phenocopied by mice carrying similar mutations and can be fully rescued by asprosin...
November 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29099978/glucose-dependent-insulinotropic-polypeptide-gip-inhibits-bone-resorption-independently-of-insulin-and-glycemia
#15
Mikkel B Christensen, Asger Lund, Salvatore Calanna, Niklas R Jørgensen, Jens J Holst, Tina Vilsbøll, Filip K Knop
Context: The gut hormone GIP causes postprandial insulin release and inhibits bone resorption assessed by carboxy-terminal collagen crosslinks (CTX). Objective: To clarify if GIP affects biomarkers involved in bone homeostasis independently of insulin release and glycemic level. Design: Randomized, double-blinded, cross-over study with 5 study days. Patients: Ten lean male C-peptide-negative patients with type 1 diabetes...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29099626/contribution-of-structured-self-monitoring-of-blood-glucose-to-the-glycemic-control-and-the-quality-of-life-in-both-insulin-and-noninsulin-treated-patients-with-poorly-controlled-diabetes
#16
Kai Kan, Wei Zhu, Fengdi Lu, Yun Shen, Fei Gao, Yifei Mo, Xingxing He, Yuqian Bao, Jian Zhou, Weiping Jia
BACKGROUND: The rate of glycemic control among diabetes patients in China is currently low. The current study aims at determining the effect of structured self-monitoring of blood glucose (SMBG) on blood glucose control as well as quality of life (QoL) in Chinese diabetes patients. METHODS: In a 24-week, single-center, randomized, open-label, prospective trial, patients with glycated hemoglobin A1c (HbA1c) >8.0% were randomized to an intervention group for structured SMBG (n = 121) or a control group (n = 129)...
November 3, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29098639/tef-the-rising-ancient-cereal-what-do-we-know-about-its-nutritional-and-health-benefits
#17
Habtu Shumoy, Katleen Raes
This review covers the nutritional significance of tef cereal as compared to other common cereals with emphasis on carbohydrate content and starch digestibility, protein content, iron and zinc bioavailability and antioxidant potentials. Tef is a gluten free cereal and contains the highest iron and calcium among other cereals. It has high micro- and macro- nutritional profile and is becoming globally popular in the healthy grain food chain. Tef starch has a high gelatinization temperature, an essential precondition in the preparation of low glycemic index foods...
November 2, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29098544/preserving-duodenal-jejunal-foregut-transit-does-not-impair-glucose-tolerance-and-diabetes-remission-following-gastric-bypass-in-type-2-diabetes-sprague-dawley-rat-model
#18
Ponnie R Dolo, Libin Yao, Chao Li, Xiaocheng Zhu, Linsen Shi, Jason Widjaja
BACKGROUND: Possible mechanisms underlying diabetes remission following Roux-en-Y gastric bypass (RYGB) include eradication of putative factor(s) with duodenal-jejunal bypass. OBJECTIVE: The objective of this study is to observe the effects of duodenal-jejunal transit on glucose tolerance and diabetes remission in gastric bypass rat model. METHOD: In order to verify the effect of duodenal-jejunal transit on glucose tolerance and diabetes remission in gastric bypass, 22 type 2 diabetes Sprague-Dawley rat models established through high-fat diet and low-dose streptozotocin (STZ) administered intraperitoneally were assigned to one of three groups: gastric bypass with duodenal-jejunal transit (GB-DJT n = 8), gastric bypass without duodenal-jejunal transit (RYGB n = 8), and sham (n = 6)...
November 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29091477/evaluation-of-a-new-digital-automated-glycemic-pattern-detection-tool
#19
María José Comellas, Emma Albiñana, Maite Artes, Rosa Corcoy, Diego Fernández-García, Jorge García-Alemán, Beatriz García-Cuartero, Cintia González, María Teresa Rivero, Núria Casamira, Jörg Weissmann
BACKGROUND: Blood glucose meters are reliable devices for data collection, providing electronic logs of historical data easier to interpret than handwritten logbooks. Automated tools to analyze these data are necessary to facilitate glucose pattern detection and support treatment adjustment. These tools emerge in a broad variety in a more or less nonevaluated manner. The aim of this study was to compare eDetecta, a new automated pattern detection tool, to nonautomated pattern analysis in terms of time investment, data interpretation, and clinical utility, with the overarching goal to identify early in development and implementation of tool areas of improvement and potential safety risks...
November 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29089617/low-dose-doxycycline-decreases-systemic-inflammation-and-improves-glycemic-control-lipid-profiles-and-islet-morphology-and-function-in-db-db-mice
#20
Na Wang, Xiong Tian, Yu Chen, Hui-Qi Tan, Pei-Jian Xie, Shao-Jun Chen, Yu-Cai Fu, Yi-Xin Chen, Wen-Can Xu, Chi-Ju Wei
The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal fat, Lee's index, and liver cholesterol. Blood HDL-cholesterol increased, but total cholesterol and aspartate transaminase decreased. Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products...
October 31, 2017: Scientific Reports
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