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https://www.readbyqxmd.com/read/28928117/risk-factors-for-severe-hypoglycemia-in-black-and-white-adults-with-diabetes-the-atherosclerosis-risk-in-communities-aric-study
#1
Alexandra K Lee, Clare J Lee, Elbert S Huang, A Richey Sharrett, Josef Coresh, Elizabeth Selvin
OBJECTIVE: Severe hypoglycemia is a rare but important complication of type 2 diabetes. Few studies have examined the epidemiology of hypoglycemia in a community-based population. RESEARCH DESIGN AND METHODS: We included 1,206 Atherosclerosis Risk in Communities (ARIC) Study participants with diagnosed diabetes (baseline, 1996-1998). Severe hypoglycemic events were identified through 2013 by ICD-9 codes from claims for hospitalizations, emergency department visits, and ambulance use...
September 19, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28924074/postprandial-glucose-surges-after-extremely-low-carbohydrate-diet-in-healthy-adults
#2
Koji Kanamori, Noriko Ihana-Sugiyama, Ritsuko Yamamoto-Honda, Tomoka Nakamura, Chie Sobe, Shigemi Kamiya, Miyako Kishimoto, Hiroshi Kajio, Kimiko Kawano, Mitsuhiko Noda
Carbohydrate-restricted diets are prevalent not only in obese people but also in the general population to maintain appropriate body weight. Here, we report that extreme carbohydrate restriction for one day affects the subsequent blood glucose levels in healthy adults. Ten subjects (median age 30.5 years, BMI 21.1 kg/m(2), and HbA1c 5.5%), wearing with a continuous glucose monitoring device, were given isoenergetic test meals for 4 consecutive days. On day 1, day 2 (D2), and day 4 (D4), they consumed normal-carbohydrate (63-66% carbohydrate) diet, while on day 3, they took low-carbohydrate/high-fat (5% carbohydrate) diet...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28917947/effect-of-meal-glycemic-load-and-caffeine-consumption-on-prolonged-monotonous-driving-performance
#3
Christopher Bragg, Ben Desbrow, Susan Hall, Christopher Irwin
OBJECTIVE: Monotonous driving involves low levels of stimulation and high levels of repetition and is essentially an exercise in sustained attention and vigilance. The aim of this study was to determine the effects of consuming a high or low glycemic load meal on prolonged monotonous driving performance. The effect of consuming caffeine with a high glycemic load meal was also examined. METHOD: Ten healthy, non-diabetic participants (7 males, age 51±7yrs, mean±SD) completed a repeated measures investigation involving 3 experimental trials...
September 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28902144/implementing-low-cost-community-based-exercise-programs-for-middle-aged-and-older-patients-with-type-2-diabetes-what-are-the-benefits-for-glycemic-control-and-cardiovascular-risk
#4
Romeu Mendes, Nelson Sousa, Victor Machado Reis, Jose Luis Themudo-Barata
BACKGROUND: The purpose of this study was to analyze the effects of a long-term, community-based, combined exercise program developed with low-cost exercise strategies on glycemic control and cardiovascular risk factors in middle-aged and older patients with type 2 diabetes. METHODS: Participants (n = 124; 63.25 ± 7.20 years old) engaged in either a 9-month supervised exercise program (n = 39; consisting of combined aerobic, resistance, agility/balance, and flexibility exercise; three sessions per week; 70 min per session) or a control group (n = 85) who maintained their usual care...
September 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28901167/effect-of-ischemic-postconditioning-on-myocardial-function-and-infarct-size-following-reperfusion-injury-in-diabetic-rats-pretreated-with-vildagliptin
#5
Goltaj Bayrami, Pouran Karimi, Fariba Agha-Hosseini, Saeid Feyzizadeh, Reza Badalzadeh
BACKGROUND: Cardioprotective actions of ischemic postconditioning (IPostC) against ischemia/reperfusion (I/R) injury are abolished in diabetic hearts. This study has investigated the combined effects of IPostC and vildagliptin (Vilda) on myocardial function and infarct size (IS) against I/R injury in diabetic myocardium. METHODS: Diabetes was induced by a high-fat diet/low dose of streptozotocin (35 mg/kg; intraperitoneally) in Wistar rats (200-250 g) and lasted for 12 weeks...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28899393/the-mixed-benefit-of-low-lipoprotein-a-in-type-2-diabetes
#6
Michel P Hermans, Sylvie A Ahn, Michel F Rousseau
BACKGROUND: Lipoprotein(a) (Lp(a)), a variant low-density lipoprotein (LDL), is a major genetic risk factor for cardiovascular disease. It is unknown whether an inverse relationship exists between Lp(a) and β-cell function (BCF), as for LDL-cholesterol (LDL-C) lowering by statins. We therefore assessedthe cardiometabolic phenotype of 340 men with type 2 diabetes mellitus (T2DM) in relation to Lp(a), focusing on BCF and hyperbolic product [BxS], which adjusts BCF to insulin sensitivity and secretion...
September 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#7
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28892156/a-randomized-controlled-trial-evaluating-polydextrose-as-a-fiber-in-a-wet-and-dry-matrix-on-glycemic-control
#8
Sajida Rahman, Anqi Zhao, Di Xiao, Eunyoung Park, Indika Edirisinghe, Britt M Burton-Freeman
Functional fibers can help Americans increase their fiber intake by incorporating extracted or synthesized fibers into food products. The United States Food and Drug Administration has recently proposed that "added" fibers must demonstrate a physiological health benefit, such as glucose control, to be included on the Nutrition Facts label as a dietary fiber. The objective of this study was to assess the effects of polydextrose (PDX), a water-soluble glucose polymer resistant to mammalian digestion, on postprandial glucose concentrations when added to relatively high moisture (beverage) versus low moisture (bar) food products...
September 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28878943/obstructive-sleep-apnea-in-adults-with-type-1-and-type-2-diabetes-perspectives-from-a-quality-improvement-initiative-in-a-university-based-diabetes-center
#9
Simona Ioja, Eileen R Chasens, Jason Ng, Patrick J Strollo, Mary T Korytkowski
OBJECTIVE: Obstructive sleep apnea (OSA) and diabetes are frequent comorbid conditions. Screening for OSA in patients with diabetes is recommended but the frequency with which this is done in clinical practice is unknown. The objectives of this quality improvement initiative were to identify clinician and patient perceptions regarding OSA and to identify the prevalence of patients at high risk for OSA (HROSA). METHODS: A quality improvement initiative was conducted to query clinicians and patients attending a specialty diabetes clinic regarding attitudes and beliefs related to OSA...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28878941/clinical-profiles-comorbidities-and-complications-of-type-2-diabetes-mellitus-in-patients-from-united-arab-emirates
#10
Herbert F Jelinek, Wael M Osman, Ahsan H Khandoker, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Alsafar
OBJECTIVE: To assess clinical profiles of patients with type 2 diabetes in the United Arab Emirates (UAE), including patterns, frequencies, and risk factors of microvascular and macrovascular complications. RESEARCH DESIGN AND METHODS: Four hundred and ninety patients with type 2 diabetes were enrolled from two major hospitals in Abu Dhabi. The presence of microvascular and macrovascular complications was assessed using logistic regression, and demographic, clinical and laboratory data were collected...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28875722/diabetes-injectable-therapy-type-2-diabetes-management-in-danish-practice
#11
Daniel Sterzi, Sébastien Auziere, Marie Markert Jensen, Sandra Lopes
Most diabetes care is done by GPs in Denmark. This study aimed to identify the barriers for GPs to initiate injectable therapies and reasons for referral to specialists. The web-interview conducted included 85 GPs, and 30 specialists experienced in type 2 diabetes (T2D). GPs felt more comfortable with initiating the 1(st) injectable therapy (defined as a glucagon-like peptide-1 receptor agonist (GLP-1 RA) or basal insulin) than the 2(nd) (defined as adding a basal insulin in patients treated with a GLP-1 RA (± OADs), or adding either a GLP-1 RA or a bolus insulin in patients treated with basal insulin (± OADs)...
September 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28875237/uncoupling-protein-2-inhibition-exacerbates-glucose-fluctuation-mediated-neuronal-effects
#12
Susana Cardoso, Raquel M Seiça, Paula I Moreira
Though glucose fluctuations have been considered as an adverse factor for the development of several diabetes-related complications, their impact in the central nervous system is still not fully elucidated. This study was conducted to evaluate the responses of neuronal cells to different glycemic exposures alongside to elucidate the role of uncoupling protein 2 (UCP2) in regulating such responses. To achieve our goals, primary cortical neurons were submitted to constant high (HG)/low (LG) or glucose level variations (GVs), and the pharmacological inhibition of UCP2 activity was performed using genipin...
September 5, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28874181/effect-of-an-intensive-nutrition-intervention-of-a-high-protein-and-low-glycemic-index-diet-on-weight-of-kidney-transplant-recipients-study-protocol-for-a-randomized-clinical-trial
#13
Elis Forcellini Pedrollo, Bruna Bellincanta Nicoletto, Larissa Salomoni Carpes, Júlia de Melo Cardoso de Freitas, Julia Roberta Buboltz, Cristina Carra Forte, Andrea Carla Bauer, Roberto Ceratti Manfro, Gabriela Corrêa Souza, Cristiane Bauermann Leitão
BACKGROUND: Excessive weight gain is commonly observed within the first year after kidney transplantation and is associated with negative outcomes, such as graft loss and cardiovascular events. The purpose of this study is to evaluate the effect of a high protein and low glycemic-index diet on preventing weight gain after kidney transplantation. METHODS: We designed a prospective, single-center, open-label, randomized controlled study to compare the efficacy of a high protein (1...
September 6, 2017: Trials
https://www.readbyqxmd.com/read/28870473/short-term-effects-of-a-low-glycemic-index-carob-containing-snack-on-energy-intake-satiety-and-glycemic-response-in-normal-weight-healthy-adults-results-from-two-randomized-trials
#14
Emilia Papakonstantinou, Nickolaos Orfanakos, Paul Farajian, Anastasia E Kapetanakou, Ifigenia P Makariti, Nikolaos Grivokostopoulos, Marie-Ann Ha, Panagiotis N Skandamis
OBJECTIVES: The potential positive health effects of carob-containing snacks are largely unknown. Therefore, the aims of these studies were to determine the glycemic index (GI) of a carob snack compared with chocolate cookie containing equal amounts of available carbohydrates and to compare the effects of a carob versus chocolate cookie preload consumed as snack before a meal on (a) short-term satiety response measured by subsequent ad libitum meal intake, (b) subjective satiety as assessed by visual analog scales and (c) postprandial glycemic response...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28867097/nutritional-composition-in-relation-to-glycemic-potential-of-popular-indian-rice-varieties
#15
V S S Prasad, A Hymavathi, V Ravindra Babu, T Longvah
Diabetes, a chronic hyperglycemic disorder, is a public health concern in India. High glycemic carbohydrate foods are linked to higher risk of diabetes. The chemical composition and in vivo glycemic potential of popular Indian rice varieties namely Jaya, Lalat, NDR-97, PR-113, Salivahana, Sasyasree, Savithri, Tellahamsa, Triguna, Varalu and one hybrid DRRH-3, having wide agronomical and grain morphological features were studied. Nutrient composition varied prominently among different varieties. Resistant starch (RS) content (2...
January 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28864997/rationale-design-and-baseline-characteristics-of-the-utopia-trial-for-preventing-diabetic-atherosclerosis-using-an-sglt2-inhibitor-a-prospective-randomized-open-label-parallel-group-comparative-study
#16
Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi, Isao Hayashi, Satoru Sumitani, Mamiko Tsugawa, Makoto Ohashi, Hideki Taki, Tadashi Nakamura, Satoshi Kawashima, Yasunori Sato, Hirotaka Watada, Iichiro Shimomura
INTRODUCTION: Sodium-glucose co-transporter-2 (SGLT2) inhibitors are anti-diabetic agents that improve glycemic control with a low risk of hypoglycemia and ameliorate a variety of cardiovascular risk factors. The aim of the ongoing study described herein is to investigate the preventive effects of tofogliflozin, a potent and selective SGLT2 inhibitor, on the progression of atherosclerosis in subjects with type 2 diabetes (T2DM) using carotid intima-media thickness (IMT), an established marker of cardiovascular disease (CVD), as a marker...
September 1, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28856591/tsh-oscillations-in-young-patients-with-type-1-diabetes-may-be-due-to-glycemic-variability
#17
G Bellastella, M I Maiorino, L Scappaticcio, O Casciano, M Petrizzo, M Caputo, V A Paglionico, D Giugliano, K Esposito
PURPOSE: A relationship between thyroid dysfunction and diabetes mellitus has been described by several authors but the role of glycemic variability is still unclear. We planned the present study to evaluate the influence of glycemic variability on thyroid hormones and TSH concentrations in patients with type 1 diabetes mellitus (T1DM). METHODS: Seventy-seven young patients with T1DM were enrolled and evaluated for basal glucose concentrations, HbA1c, thyroid hormones and TSH concentrations...
August 30, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28853992/effect-of-incorporating-bay-leaves-in-cookies-on-postprandial-glycemia-appetite-palatability-and-gastrointestinal-well-being
#18
Imran Khan, Seema Shah, Jamil Ahmad, Aiman Abdullah, Stuart K Johnson
BACKGROUND: Previous studies of patients with type 2 diabetes showed that capsules containing 1, 2, and 3 g of bay leaves lower fasting blood glucose, triglycerides, low-density lipoprotein cholesterol, and total cholesterol concentrations after 30 days of treatment. However, the acute effect of bay leaves on postprandial glycemic and appetite responses has not yet been determined. OBJECTIVE: The objective of this study was to determine the effect of cookies containing different doses of bay leaves on postprandial glycemia, appetite, palatability, and gastrointestinal well-being in healthy subjects...
August 30, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28853334/identification-of-novel-ppar%C3%AE-%C3%AE-dual-agonists-by-virtual-screening-admet-prediction-and-molecular-dynamics-simulations
#19
Xin Liu, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Ying Ma, Wei-Ren Xu, Xian-Chao Cheng
PPARα and PPARγ have been the most widely studied Peroxisome Proliferator-Activated Receptor (PPAR) subtypes due to their important roles in regulating glucose, lipids and cholesterol metabolism. By combining the lowering serum triglyceride levels benefit of PPARα agonists (such as fibrates) with the glycemic advantages of the PPARγ agonists (such as TZD), the dual PPAR agonists approach can both improve the metabolic effects and minimize the side effects caused by either agent alone, and hence has become a promising strategy for designing effective drugs against type-2 diabetes...
August 30, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28851931/dietary-glycemic-index-glycemic-load-and-cancer-risk-results-from-the-epic-italy-study
#20
S Sieri, C Agnoli, V Pala, S Grioni, F Brighenti, N Pellegrini, G Masala, D Palli, A Mattiello, S Panico, F Ricceri, F Fasanelli, G Frasca, R Tumino, V Krogh
Factors linked to glucose metabolism are involved in the etiology of several cancers. High glycemic index (GI) or high glycemic load (GL) diets, which chronically raise postprandial blood glucose, may increase cancer risk by affecting insulin-like growth factor. We prospectively investigated cancer risk and dietary GI/GL in the EPIC-Italy cohort. After a median 14.9 years, 5112 incident cancers and 2460 deaths were identified among 45,148 recruited adults. High GI was associated with increased risk of colon and bladder cancer...
August 29, 2017: Scientific Reports
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