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https://www.readbyqxmd.com/read/29783671/views-and-experiences-of-persons-with-chronic-diseases-about-strategies-that-aim-to-integrate-and-re-integrate-them-into-work-a-systematic-review-of-qualitative-studies
#1
Eva Esteban, Michaela Coenen, Elizabeth Ito, Sonja Gruber, Chiara Scaratti, Matilde Leonardi, Olga Roka, Evdokia Vasilou, Amalia Muñoz-Murillo, Carolina C Ávila, Dare S Kovačič, Ivana Ivandic, Carla Sabariego
The effectiveness of strategies targeting professional integration and reintegration strongly depends on the experiences of participants. The aim of this systematic literature review is to synthesize European qualitative studies exploring views and experiences of persons with chronic conditions regarding strategies for integration and reintegration into work. The systematic search was conducted in Medline, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 24 studies published in English between January 2011 and April 2016 were included...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29765088/performance-boost-for-primary-magnesium-cells-using-iron-complexing-agents-as-electrolyte-additives
#2
Daniel Höche, Sviatlana V Lamaka, Bahram Vaghefinazari, Tobias Braun, Rokas P Petrauskas, Maximilian Fichtner, Mikhail L Zheludkevich
Aqueous Mg battery technology holds significant appeal, owing to the availability of raw materials, high power densities and the possibility of fast mechanical recharge. However, Mg batteries have so far been prone to decreased capacity due to self-corrosion of the anodes from the electrochemical redeposition of impurities, such as Fe, which results in parasitic cathodically active sites on the discharging anode. This work demonstrates that by adding Fe3+ -complexing agents like Tiron or salicylate to the aqueous electrolyte of an Mg battery, it was possible to prevent the redeposition of Fe impurities and subsequent self-corrosion of the anode surface, thereby boosting battery performance...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764520/investigation-of-a-typhoid-fever-epidemic-in-moyale-sub-county-kenya-2014-2015
#3
Dahabo Adi Galgallo, Zeinab Gura Roka, Waqo G Boru, Khalumi Abill, James Ransom
AIM: Typhoid fever is a vaccine-preventable bacterial disease that causes significant morbidity and mortality throughout Africa. This paper describes an upsurge of typhoid fever cases in Moyale Sub-County (MSC), Kenya, 2014-2015. METHODS: We conducted active hospital and health facility surveillance and laboratory and antimicrobial sensitivity testing for all patients presenting with headache, fever, stomach pains, diarrhea, or constipation at five MSC health facilities between December 2014 and January 2015...
May 15, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29760453/evolutionary-instability-of-cug-leu-in-the-genetic-code-of-budding-yeasts
#4
Tadeusz Krassowski, Aisling Y Coughlan, Xing-Xing Shen, Xiaofan Zhou, Jacek Kominek, Dana A Opulente, Robert Riley, Igor V Grigoriev, Nikunj Maheshwari, Denis C Shields, Cletus P Kurtzman, Chris Todd Hittinger, Antonis Rokas, Kenneth H Wolfe
The genetic code used in nuclear genes is almost universal, but here we report that it changed three times in parallel during the evolution of budding yeasts. All three changes were reassignments of the codon CUG, which is translated as serine (in 2 yeast clades), alanine (1 clade), or the 'universal' leucine (2 clades). The newly discovered Ser2 clade is in the final stages of a genetic code transition. Most species in this clade have genes for both a novel tRNASer (CAG) and an ancestral tRNALeu (CAG) to read CUG, but only tRNASer (CAG) is used in standard growth conditions...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29724166/surveying-alignment-free-features-for-ortholog-detection-in-related-yeast-proteomes-by-using-supervised-big-data-classifiers
#5
Deborah Galpert, Alberto Fernández, Francisco Herrera, Agostinho Antunes, Reinaldo Molina-Ruiz, Guillermin Agüero-Chapin
BACKGROUND: The development of new ortholog detection algorithms and the improvement of existing ones are of major importance in functional genomics. We have previously introduced a successful supervised pairwise ortholog classification approach implemented in a big data platform that considered several pairwise protein features and the low ortholog pair ratios found between two annotated proteomes (Galpert, D et al., BioMed Research International, 2015). The supervised models were built and tested using a Saccharomycete yeast benchmark dataset proposed by Salichos and Rokas (2011)...
May 3, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29699616/propranolol-versus-metoprolol-for-treatment-of-electrical-storm-in-patients-with-implantable-cardioverter-defibrillator
#6
Sofia Chatzidou, Christos Kontogiannis, Diamantis I Tsilimigras, Georgios Georgiopoulos, Marinos Kosmopoulos, Elektra Papadopoulou, Georgios Vasilopoulos, Stylianos Rokas
BACKGROUND: Electrical storm (ES), characterized by unrelenting recurrences of ventricular arrhythmias, is observed in approximately 30% of patients with implantable cardioverter-defibrillators (ICDs) and is associated with high mortality rates. OBJECTIVES: Sympathetic blockade with β-blockers, usually in combination with intravenous (IV) amiodarone, have proved highly effective in the suppression of ES. In this study, we compared the efficacy of a nonselective β-blocker (propranolol) versus a β1 -selective blocker (metoprolol) in the management of ES...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29673231/mapping-european-welfare-models-state-of-the-art-of-strategies-for-professional-integration-and-reintegration-of-persons-with-chronic-diseases
#7
Chiara Scaratti, Matilde Leonardi, Fabiola Silvaggi, Carolina C Ávila, Amalia Muñoz-Murillo, Panayiota Stavroussi, Olga Roka, Helena Burger, Klemens Fheodoroff, Beata Tobiasz-Adamczyk, Carla Sabariego, Eva Esteban, Sonja Gruber, Olga Svestkova, Rune Halvorsen, Asel Kadyrbaeva, Sabrina Ferraina
Background: Persons with chronic diseases (PwCDs) often experience work-related problems, and innovative actions to improve their participation in the labor market are needed. In the frame of the European (EU) Pathways Project, the aim of the study is to compare existing strategies (policies, systems, and services) for professional (re-)integration of PwCDs and mental health conditions available at both European and national level between different European welfare models: Scandinavian, Continental, Anglo-Saxon, Mediterranean, and “Post-Communist”...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29648535/evidence-for-loss-and-reacquisition-of-alcoholic-fermentation-in-a-fructophilic-yeast-lineage
#8
Carla Gonçalves, Jennifer H Wisecaver, Jacek Kominek, Madalena Salema Oom, Maria José Leandro, Xing-Xing Shen, Dana A Opulente, Xiaofan Zhou, David Peris, Cletus P Kurtzman, Chris Todd Hittinger, Antonis Rokas, Paula Gonçalves
Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella / Starmerella , W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene...
April 12, 2018: ELife
https://www.readbyqxmd.com/read/29622979/anomalous-origin-of-left-main-coronary-artery-from-the-right-sinus-of-valsalva-presenting-as-non-st-elevation-acute-coronary-syndrome-a-case-report
#9
Anish Hirachan, Arun Maskey, Gopi Prasad Hirachan, Madhu Roka
Congenital anomalies of the coronary arteries are a cause of sudden cardiac death. Of the known anatomic variants, anomalous origination of a coronary artery from an opposite sinus of Valsalva (ACAOS) remains a major clinical issue and a challenging condition to treat. Congenital coronary anomalies are likely to be under-recognized, as completing an anatomic assessment in a very large portion of the population would seem unfeasible. However, we present a case report with image of a 49 year old male presented with acute non-ST elevation ACS for which he underwent diagnostic angiography of the coronary system which revealed a common origin of both right and left main coronary artery from right sinus of Valsalva with significant obstructive lesion in the mid segment of right coronary artery...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29564395/an-laea-and-brla-dependent-cellular-network-governs-tissue-specific-secondary-metabolism-in-the-human-pathogen-aspergillus-fumigatus
#10
Abigail L Lind, Fang Yun Lim, Alexandra A Soukup, Nancy P Keller, Antonis Rokas
Biosynthesis of many ecologically important secondary metabolites (SMs) in filamentous fungi is controlled by several global transcriptional regulators, like the chromatin modifier LaeA, and tied to both development and vegetative growth. In Aspergillus molds, asexual development is regulated by the BrlA > AbaA > WetA transcriptional cascade. To elucidate BrlA pathway involvement in SM regulation, we examined the transcriptional and metabolic profiles of Δ brlA , Δ abaA , and Δ wetA mutant and wild-type strains of the human pathogen Aspergillus fumigatus ...
March 2018: MSphere
https://www.readbyqxmd.com/read/29534484/policy-guidelines-for-effective-inclusion-and-reintegration-of-people-with-chronic-diseases-in-the-workplace-national-and-european-perspectives
#11
Anastasia Vlachou, Panayiota Stavroussi, Olga Roka, Evdokia Vasilou, Dimitra Papadimitriou, Chiara Scaratti, Asel Kadyrbaeva, Klemens Fheodoroff, Valentina Brecelj, Olga Svestkova, Beata Tobiasz-Adamczyk, Jon Erik Finnvold, Sonja Gruber, Matilde Leonardi
The increasing prevalence of chronic diseases among the European working age population, as well as the implications for the individual and societal level, underline the need for policy guidelines targeting the effective inclusion of persons with chronic diseases in the workplace. The aim of the present paper was to explore the perspectives of European and National-level stakeholders on existing strategies for work re-integration of persons with chronic diseases, and to provide policy guidelines. A highly-structured interview protocol was distributed to 58 National level stakeholders (policy makers, professionals and employers) from seven European countries...
March 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29525063/diagnostic-accuracy-of-a-novel-mobile-phone-application-for-the-detection-and-monitoring-of-atrial-fibrillation
#12
Guy Rozen, Jeena Vaid, Seyed Mohammadreza Hosseini, M Ihsan Kaadan, Allon Rafael, Attila Roka, Yukkee C Poh, Ming-Zher Poh, Edwin Kevin Heist, Jeremy Neil Ruskin
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults, associated with significant morbidity, increased mortality, and rising health-care costs. Simple and available tools for the accurate detection of arrhythmia recurrence in patients after electrical cardioversion (CV) or ablation procedures for AF can help to guide therapeutic decisions. We conducted a prospective, single-center study to evaluate the accuracy of Cardiio Rhythm Mobile Application (CRMA) for AF detection. Patients >18 years of age who were scheduled for elective CV for AF were enrolled in the study...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29520259/copy-number-variation-in-fungi-and-its-implications-for-wine-yeast-genetic-diversity-and-adaptation
#13
REVIEW
Jacob L Steenwyk, Antonis Rokas
In recent years, copy number (CN) variation has emerged as a new and significant source of genetic polymorphisms contributing to the phenotypic diversity of populations. CN variants are defined as genetic loci that, due to duplication and deletion, vary in their number of copies across individuals in a population. CN variants range in size from 50 base pairs to whole chromosomes, can influence gene activity, and are associated with a wide range of phenotypes in diverse organisms, including the budding yeast Saccharomyces cerevisiae ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29499717/factors-driving-metabolic-diversity-in-the-budding-yeast-subphylum
#14
Dana A Opulente, Emily J Rollinson, Cleome Bernick-Roehr, Amanda Beth Hulfachor, Antonis Rokas, Cletus P Kurtzman, Chris Todd Hittinger
BACKGROUND: Associations between traits are prevalent in nature, occurring across a diverse range of taxa and traits. Individual traits may co-evolve with one other, and these correlations can be driven by factors intrinsic or extrinsic to an organism. However, few studies, especially in microbes, have simultaneously investigated both across a broad taxonomic range. Here we quantify pairwise associations among 48 traits across 784 diverse yeast species of the ancient budding yeast subphylum Saccharomycotina, assessing the effects of phylogenetic history, genetics, and ecology...
March 2, 2018: BMC Biology
https://www.readbyqxmd.com/read/29471489/the-h-subunit-of-the-restriction-endonuclease-cgli-contains-a-prototype-dead-z1-helicase-like-motor
#15
Paulius Toliusis, Giedre Tamulaitiene, Rokas Grigaitis, Donata Tuminauskaite, Arunas Silanskas, Elena Manakova, Ceslovas Venclovas, Mark D Szczelkun, Virginijus Siksnys, Mindaugas Zaremba
CglI is a restriction endonuclease from Corynebacterium glutamicum that forms a complex between: two R-subunits that have site specific-recognition and nuclease domains; and two H-subunits, with Superfamily 2 helicase-like DEAD domains, and uncharacterized Z1 and C-terminal domains. ATP hydrolysis by the H-subunits catalyses dsDNA translocation that is necessary for long-range movement along DNA that activates nuclease activity. Here, we provide biochemical and molecular modelling evidence that shows that Z1 has a fold distantly-related to RecA, and that the DEAD-Z1 domains together form an ATP binding interface and are the prototype of a previously undescribed monomeric helicase-like motor...
March 16, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29467190/examination-of-signatures-of-recent-positive-selection-on-genes-involved-in-human-sialic-acid-biology
#16
Jiyun M Moon, David M Aronoff, John A Capra, Patrick Abbot, Antonis Rokas
Sialic acids are nine carbon sugars ubiquitously found on the surfaces of vertebrate cells and are involved in various immune response-related processes. In humans, at least 58 genes spanning diverse functions, from biosynthesis and activation to recycling and degradation, are involved in sialic acid biology. Because of their role in immunity, sialic acid biology genes have been hypothesized to exhibit elevated rates of evolutionary change. Consistent with this hypothesis, several genes involved in sialic acid biology have experienced higher rates of non-synonymous substitutions in the human lineage than their counterparts in other great apes, perhaps in response to ancient pathogens that infected hominins millions of years ago (paleopathogens)...
March 28, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29453931/comparison-of-return-to-pre-injury-sport-after-10-mm-size-bone-patellar-tendon-bone-bptb-versus-8-mm-hamstring-anterior-cruciate-ligament-reconstruction-a-retrospective-study-with-a-two-year-follow-up
#17
Rimtautas Gudas, Rokas Jurkonis, Alfredas Smailys
BACKGROUND The aim of this study was to evaluate the reconstruction of a torn anterior cruciate ligament (ACL) with 10 mm diameter BPTB (bone-patellar tendon-bone) autograft versus 8 mm HT (hamstring tendon) autografts, to compare the ability to restore pre-injury sports activities and reduce revision risk after these procedures. MATERIAL AND METHODS A prospective clinical review was performed to compare results of patients who underwent primary anatomical ACLR with 10 mm BPTB autografts with patients who underwent 8 mm diameter HT autografts, between January 2011 and January 2014...
February 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29408019/impact-of-atrial-fibrillation-on-cognitive-function-psychological-distress-quality-of-life-and-impulsiveness
#18
Rokas Serpytis, Aurelija Navickaite, Emilija Serpytiene, Jurate Barysiene, Germanas Marinskis, Dalius Jatuzis, Zaneta Petrulioniene, Aleksandras Laucevicius, Pranas Serpytis
OBJECTIVE: Atrial fibrillation is the most common cardiac arrhythmia and a known risk factor for cerebrovascular stroke. Atrial fibrillation and longstanding hypertension may produce ischemic lesions leading to progressive cognitive impairment. The impact of atrial fibrillation alone on cognitive impairment has not been evaluated. Our objective was to compare cognitive function, quality of life, psychological distress, and impulsiveness in people with atrial fibrillation and a matched control group...
January 31, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29401890/aberration-controlled-bessel-beam-processing-of-glass
#19
Juozas Dudutis, Rokas Stonys, Gediminas Račiukaitis, Paulius Gečys
It is known that Bessel beam generation with a non-ideal axicon induces beam pattern distortions. In this paper, we introduce a simple method for non-ideal axicon-generated Bessel beam reconstruction by tilting the axicon perpendicular to its optical axis. We found an optimum axicon tilt angle where beam distortions can be compensated by inducing additional astigmatic aberrations. At optimal tilt angle, the central spot symmetry and focal depth was increased. By this method we could control crack formation symmetry in the bulk of glass, which is essential for many transparent material processing applications...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29396982/use-of-social-media-and-an-online-survey-to-discuss-complex-reconstructive-surgery-a-case-of-upper-lip-reconstruction-with-402-responses-from-international-microsurgeons
#20
Soo-Ha Kwon, Che-Hsiung Lee, Angela Ting-Wei Hsu, Mark Shafarenko, Usama Farghaly Omar, Chieh-Han John Tzou, Julia Roka-Palkovits, Aldo G Beltrán P, Dimitri Liakos, Tommy Nai-Jen Chang
BACKGROUND: The best reconstructive strategy for upper lip defects is still in debate. The purpose of this study was to analyze the decisions made by international microsurgeons, who were participated through online questionnaire, distributed by email and social media network. MATERIALS AND METHODS: A case of a two-thirds upper lip oncologic defect was presented via an online questionnaire and 402 microsurgeons replied their treatment options. The data were then analyzed according to the geographic area, microsurgical fellowship, seniority, and subspecialty...
February 2, 2018: Journal of Reconstructive Microsurgery
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