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https://www.readbyqxmd.com/read/27892489/laser-light-induced-transformation-of-molybdenum-disulphide-based-nanoplatelet-arrays
#1
Arūnas Jagminas, Gediminas Niaura, Rokas Žalnėravičius, Romualdas Trusovas, Gediminas Račiukaitis, Vitalija Jasulaitiene
One-pot hydrothermal synthesis of MoS2 nanoplatelet arrays on various substrates is perhaps the most promising approach to fabricate efficient electrocatalysts for hydrogen evolution reaction. However, the main challenges in this synthesis remain the purity and crystallinity of MoS2. In this study, we show for the first time that irradiation of amorphous, defect-rich MoS2 nanoplatelets with a green nanosecond laser at a proper irradiation dose, ca ≤0.35 J cm(-2), can significantly improve the crystallinity and purity of MoS2 nanoplatelets...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27886934/coronary-sinus-lead-positioning
#2
REVIEW
Attila Roka, Rasmus Borgquist, Jagmeet Singh
Although cardiac resynchronization therapy improves morbidity and mortality in patients with cardiomyopathy, heart failure, and electrical dyssynchrony, the rate of nonresponders using standard indications and implant techniques is still high. Optimal coronary sinus lead positioning is important to increase the chance of successful resynchronization. Patient factors such as cause of heart failure, type of dyssynchrony, scar burden, coronary sinus anatomy, and phrenic nerve capture may affect the efficacy of the therapy...
January 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/27845382/effect-of-bio-engineering-on-size-shape-composition-and-rigidity-of-bacterial-microcompartments
#3
Matthias J Mayer, Rokas Juodeikis, Ian R Brown, Stefanie Frank, David J Palmer, Evelyne Deery, David M Beal, Wei-Feng Xue, Martin J Warren
Bacterial microcompartments (BMCs) are proteinaceous organelles that are found in a broad range of bacteria and are composed of an outer shell that encases an enzyme cargo representing a specific metabolic process. The outer shell is made from a number of different proteins that form hexameric and pentameric tiles, which interact to allow the formation of a polyhedral edifice. We have previously shown that the Citrobacter freundii BMC associated with 1,2-propanediol utilization can be transferred into Escherichia coli to generate a recombinant BMC and that empty BMCs can be formed from just the shell proteins alone...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27795893/genetic-assessment-of-captive-red-panda-ailurus-fulgens-population
#4
Arun Kumar, Upashna Rai, Bhupen Roka, Alankar K Jha, P Anuradha Reddy
Red panda (Ailurus fulgens) is threatened across its range by detrimental human activities and rapid habitat changes necessitating captive breeding programs in various zoos globally to save this flagship species from extinction. One of the ultimate aims of ex situ conservation is reintroduction of endangered animals into their natural habitats while maintaining 90 % of the founder genetic diversity. Advances in molecular genetics and microsatellite genotyping techniques make it possible to accurately estimate genetic diversity of captive animals of unknown ancestry...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27794353/relative-acoustic-frequency-response-of-induced-methane-carbon-dioxide-and-air-gas-bubble-plumes-observed-laterally
#5
Rokas Kubilius, Geir Pedersen
There is an increased need to detect, identify, and monitor natural and manmade seabed gas leaks. Fisheries echosounders are well suited to monitor large volumes of water and acoustic frequency response [normalized acoustic backscatter, when a measure at one selected frequency is used as a denominator, r(f)] is commonly used to identify echoes from fish and zooplankton species. Information on gas plume r(f) would be valuable for automatic detection of subsea leaks and for separating bubble plumes from natural targets such as swimbladder-bearing fish...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27785347/sex-and-gender-in-medical-education-a-national-student-survey
#6
Marjorie R Jenkins, Alyssa Herrmann, Amanda Tashjian, Tina Ramineni, Rithika Ramakrishnan, Donna Raef, Tracy Rokas, John Shatzer
BACKGROUND: Gender- and sex-specific medicine is defined as the practice of medicine based on the understanding that biology (dictated by sex chromosomes) and social roles (gender) are important in and have implications for prevention, screening, diagnosis, and treatment in men and women. In light of the many ways that sex and gender influence disease presentation and patient management, there have been various initiatives to improve the integration of these topics into medical education curriculum...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27746117/sentinel-lymph-node-biopsy-for-high-risk-cutaneous-squamous-cell-carcinoma-analysis-of-recurrence-free-survival
#7
Donatas Samsanavičius, Vygintas Kaikaris, Simonas-Jonas Norvydas, Rokas Liubauskas, Skaidra Valiukevičienė, Jurgita Makštienė, Kęstutis Maslauskas, Rytis Rimdeika
BACKGROUND AND AIM: Cutaneous squamous cell carcinoma (CSCC) is a malignant epithelial cell tumor. CSCC has a tendency to spread via lymphogenic pathway. Metastases are found in 2%-6% of cases. Prognosis of patients with CSCC is directly related to the morphology and localization of primary tumor. The aim of this study was to evaluate the recurrence-free survival of patients with CSCC after tumor excision and SLNB as well as to analyze morphologic CSCC features related to patient recurrence-free survival...
2016: Medicina
https://www.readbyqxmd.com/read/27694115/regulation-of-secondary-metabolism-by-the-velvet-complex-is-temperature-responsive-in-aspergillus
#8
Abigail L Lind, Timothy D Smith, Timothy Saterlee, Ana M Calvo, Antonis Rokas
Sensing and responding to environmental cues is critical to the lifestyle of filamentous fungi. How environmental variation influences fungi to produce a wide diversity of ecologically important secondary metabolites (SMs) is not well understood. To address this question, we first examined changes in global gene expression of the opportunistic human pathogen Aspergillus fumigatus after exposure to different temperature conditions. We found that 11 of the 37 SM gene clusters in A. fumigatus were expressed at higher levels at 30°C than at 37°C...
September 30, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27672114/reconstructing-the-backbone-of-the-saccharomycotina-yeast-phylogeny-using-genome-scale-data
#9
Xing-Xing Shen, Xiaofan Zhou, Jacek Kominek, Cletus P Kurtzman, Chris Todd Hittinger, Antonis Rokas
Understanding the phylogenetic relationships among the yeasts of the subphylum Saccharomycotina is a prerequisite for understanding the evolution of their metabolisms and ecological lifestyles. In the last two decades, the use of rDNA and multi-locus data sets has greatly advanced our understanding of the yeast phylogeny, but many deep relationships remain unsupported. In contrast, phylogenomic analyses have involved relatively few taxa and lineages that were often selected with limited considerations for covering the breadth of yeast biodiversity...
September 26, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27669200/efficacy-of-pre-and-post-treatment-by-topical-formulations-containing-dissolved-and-suspended-silybum-marianum-against-uvb-induced-oxidative-stress-in-guinea-pig-and-on-hacat-keratinocytes
#10
Pálma Fehér, Zoltán Ujhelyi, Judit Váradi, Ferenc Fenyvesi, Eszter Róka, Béla Juhász, Balázs Varga, Mariann Bombicz, Dániel Priksz, Ildikó Bácskay, Miklós Vecsernyés
Plants with high amounts of antioxidants may be a promising therapy for preventing and curing UV-induced oxidative skin damage. The objective of this study was to verify the efficacy of topical formulations containing dissolved and suspended Silybum marianum extract against UVB-induced oxidative stress in guinea pig and HaCaT keratinocytes. Herbal extract was dissolved in Transcutol HP (TC) and sucrose-esters were incorporated as penetration enhancers in creams. Biocompatibility of compositions was tested on HeLa cells and HaCaT keratinocytes as in vitro models...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27661960/combined-yb-nd-driver-for-optical-parametric-chirped-pulse-amplifiers
#11
Kirilas Michailovas, Andrius Baltuska, Audrius Pugzlys, Valerijus Smilgevicius, Andrejus Michailovas, Audrius Zaukevicius, Rokas Danilevicius, Saulius Frankinas, Nerijus Rusteika
We report on the developed front-end/pump system for optical parametric chirped pulse amplifiers. The system is based on a dual output fiber oscillator/power amplifier which seeds and assures all-optical synchronization of femtosecond Yb and picosecond Nd laser amplifiers operating at a central wavelength of 1030 nm and 1064 nm, respectively. At the central wavelength of 1030 nm, the fiber oscillator generates partially stretched 4 ps pulses with the spectrum supporting a <120 fs pulse duration and pulse energy of 0...
September 19, 2016: Optics Express
https://www.readbyqxmd.com/read/27638685/in-silico-whole-genome-sequencer-analyzer-iwgs-a-computational-pipeline-to-guide-the-design-and-analysis-of-de-novo-genome-sequencing-studies
#12
Xiaofan Zhou, David Peris, Jacek Kominek, Cletus P Kurtzman, Chris Todd Hittinger, Antonis Rokas
The availability of genomes across the tree of life is highly biased toward vertebrates, pathogens, human disease models, and organisms with relatively small and simple genomes. Recent progress in genomics has enabled the de novo decoding of the genome of virtually any organism, greatly expanding its potential for understanding the biology and evolution of the full spectrum of biodiversity. The increasing diversity of sequencing technologies, assays, and de novo assembly algorithms have augmented the complexity of de novo genome sequencing projects in non-model organisms...
September 16, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27535936/comparative-genomics-of-biotechnologically-important-yeasts
#13
Robert Riley, Sajeet Haridas, Kenneth H Wolfe, Mariana R Lopes, Chris Todd Hittinger, Markus Göker, Asaf A Salamov, Jennifer H Wisecaver, Tanya M Long, Christopher H Calvey, Andrea L Aerts, Kerrie W Barry, Cindy Choi, Alicia Clum, Aisling Y Coughlan, Shweta Deshpande, Alexander P Douglass, Sara J Hanson, Hans-Peter Klenk, Kurt M LaButti, Alla Lapidus, Erika A Lindquist, Anna M Lipzen, Jan P Meier-Kolthoff, Robin A Ohm, Robert P Otillar, Jasmyn L Pangilinan, Yi Peng, Antonis Rokas, Carlos A Rosa, Carmen Scheuner, Andriy A Sibirny, Jason C Slot, J Benjamin Stielow, Hui Sun, Cletus P Kurtzman, Meredith Blackwell, Igor V Grigoriev, Thomas W Jeffries
Ascomycete yeasts are metabolically diverse, with great potential for biotechnology. Here, we report the comparative genome analysis of 29 taxonomically and biotechnologically important yeasts, including 16 newly sequenced. We identify a genetic code change, CUG-Ala, in Pachysolen tannophilus in the clade sister to the known CUG-Ser clade. Our well-resolved yeast phylogeny shows that some traits, such as methylotrophy, are restricted to single clades, whereas others, such as l-rhamnose utilization, have patchy phylogenetic distributions...
August 30, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27516824/trends-in-health-facility-based-maternal-mortality-in-central-region-kenya-2008-2012
#14
Onesmus Maina Muchemi, Agnes Wangechi Gichogo, Jane Githuku Mungai, Zeinab Gura Roka
INTRODUCTION: WHO classifies Kenya as having a high maternal mortality. Regional data on maternal mortality trends is only available in selected areas. This study reviewed health facility maternal mortality trends, causes and distribution in Central Region of Kenya, 2008-2012. METHODS: We reviewed health records from July 2008 to June 2012. A maternal death was defined according to ICD-10 criterion. The variables reviewed included socio-demographic, obstetric characteristics, reasons for admission, causes of death and contributing factors...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27492233/a-genome-scale-investigation-of-how-sequence-function-and-tree-based-gene-properties-influence-phylogenetic-inference
#15
Xing-Xing Shen, Leonidas Salichos, Antonis Rokas
Molecular phylogenetic inference is inherently dependent on choices in both methodology and data. Many insightful studies have shown how choices in methodology, such as the model of sequence evolution or optimality criterion used, can strongly influence inference. In contrast, much less is known about the impact of choices in the properties of the data, typically genes, on phylogenetic inference. We investigated the relationships between 52 gene properties (24 sequence-based, 19 function-based, and 9 tree-based) with each other and with three measures of phylogenetic signal in two assembled data sets of 2,832 yeast and 2,002 mammalian genes...
2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27452435/comprehensive-rna-profiling-of-villous-trophoblast-and-decidua-basalis-in-pregnancies-complicated-by-preterm-birth-following-intra-amniotic-infection
#16
William E Ackerman, Irina A Buhimschi, Haley R Eidem, David C Rinker, Antonis Rokas, Kara Rood, Guomao Zhao, Taryn L Summerfield, Mark B Landon, Catalin S Buhimschi
INTRODUCTION: We performed RNA sequencing with the primary goal of discovering key placental villous trophoblast (VT) and decidua basalis (DB) transcripts differentially expressed in intra-amniotic infection (IAI)-induced preterm birth (PTB). METHODS: RNA was extracted from 15 paired VT and DB specimens delivered of women with: 1) spontaneous PTB in the setting of amniocentesis-proven IAI and histological chorioamnionitis (n = 5); 2) spontaneous idiopathic PTB (iPTB, n = 5); and 3) physiologic term pregnancy (n = 5)...
August 2016: Placenta
https://www.readbyqxmd.com/read/27450930/the-influence-of-increased-membrane-conductance-on-response-properties-of-spinal-motoneurons
#17
Ramunas Grigonis, Robertas Guzulaitis, Rokas Buisas, Aidas Alaburda
During functional spinal neural network activity motoneurons receive massive synaptic excitation and inhibition, and their membrane conductance increases considerably - they are switched to a high-conductance state. High-conductance states can substantially alter response properties of motoneurons. In the present study we investigated how an increase in membrane conductance affects spike frequency adaptation, the gain (i.e., the slope of the frequency-current relationship) and the threshold for action potential generation...
October 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27357636/identifying-circulating-micrornas-as-biomarkers-of-cardiovascular-disease-a-systematic-review
#18
REVIEW
Rokas Navickas, Diane Gal, Aleksandras Laucevičius, Agnė Taparauskaitė, Monika Zdanytė, Paul Holvoet
The aim of the present study is to identify microRNAs (miRs) with high potential to be used as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis for survival in, patients with atherosclerosis, coronary artery disease, and acute coronary syndrome (ACS). A systematic search of published original research yielded a total of 72 studies. After review of the risk of bias of the published studies, according to Cochrane Collaboration and the QUADUAS Group standards, 19 studies were selected...
September 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27353521/the-surgical-anatomy-of-the-supraclavicular-lymph-node-flap-a-basis-for-the-free-vascularized-lymph-node-transfer
#19
Johannes Steinbacher, Ines E Tinhofer, Stefan Meng, Lukas F Reissig, Eva Placheta, Julia Roka-Palkovits, Thomas Rath, Ming-Huei Cheng, Wolfgang J Weninger, Chieh-Han J Tzou
BACKGROUND: Vascularized lymph node transfer is an effective surgical method in reducing lymphedema. This study provides the first detailed description of the surgical anatomy of the supraclavicular lymph node flap in regard to pedicle length, pedicle diameter, and the number of lymph nodes and their exact location inside the flap. METHODS: Bilateral supraclavicular dissections of nine fresh cadavers (five female) were performed. Before the dissection, the exact number of lymph nodes was determined sonographically by an experienced radiologist, and their distance from the jugular notch was measured...
June 28, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27338566/surgical-anatomy-of-the-vascularized-submental-lymph-node-flap-anatomic-study-of-correlation-of-submental-artery-perforators-and-quantity-of-submental-lymph-node
#20
Chieh-Han J Tzou, Stefan Meng, Tinhofer Ines, Lukas Reissig, Ursula Pichler, Johannes Steinbacher, Igor Pona, Julia Roka-Palkovits, Thomas Rath, Wolfgang J Weninger, Ming-Huei Cheng
BACKGROUND: Harvesting the submental flap for vascularized lymph node transfer (VLNT) presents a challenging procedure because of, the topographic variation of the submental artery (SA) and the marginal mandible nerve (MMN) and the limited pedicle length for a free tissue transfer. The aim of this study was to evaluate surgical anatomical landmarks and variations of the submental lymph node flap (SLNF). METHODS AND MATERIALS: The authors examined the characteristics and landmarks of 18 SLNF in nine fresh cadavers...
June 23, 2016: Journal of Surgical Oncology
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