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https://www.readbyqxmd.com/read/28631611/the-gene-family-that-cheats-mendel
#1
J Dylan Shropshire, Antonis Rokas
Some alleles of the wtf gene family can increase their chances of spreading by using poisons to kill other alleles, and antidotes to save themselves.
June 20, 2017: ELife
https://www.readbyqxmd.com/read/28523911/cup-shaped-nanoantenna-arrays-for-zeptoliter-volume-biochemistry-and-plasmonic-sensing-in-the-visible-wavelength-range
#2
Rokas Drevinskas, Tomas Rakickas, Algirdas Selskis, Lorenzo Rosa, Ramu Nas Valiokas
Although three-dimensional shaping of metallic nanostructures is an important strategy for control and manipulation of localized surface plasmon resonance (LSPR), its implementation in high-throughput, on-chip fabrication of plasmonic devices remains challenging. Here, we demonstrate nanocontact-based large-area fabrication of a novel, LSPR-active Au architecture consisting of periodic arrays of reduced-symmetry nanoantennas having sub-50 nm, out-of-plane features. Namely, by combining nanosphere and molecular self-assembly processes, we have patterned evaporated polycrystalline Au films for chemical etching of nanocups with controlled aspect ratios (outer diameter d = 100 nm and void volumes = 18 or 39 zL)...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28498473/sulforaphane-sensitizes-human-cholangiocarcinoma-to-cisplatin-via-the-downregulation-of-anti-apoptotic-proteins
#3
Rokas Račkauskas, Dachen Zhou, Simonas Ūselis, Kęstutis Strupas, Ingrid Herr, Peter Schemmer
Cholangiocarcinoma (CCC) is an aggressive malignancy with poor therapeutic options and pronounced chemotherapy resistance. The bioactive broccoli substance, sulforaphane (SFN), is a promising new therapeutic option since it has been found to induce therapeutic effects in both experimental and epidemiological studies in various tumor entities. Thus, the present study was designed to assess the effect of SFN on cisplatin sensitivity in CCC. Human HuCCT-1 and TFK-1 cells, representing intrahepatic and extrahepatic CCC, respectively, were treated with cisplatin and SFN...
May 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28418331/collagen-iv-and-basement-membrane-at-the-evolutionary-dawn-of-metazoan-tissues
#4
Aaron L Fidler, Carl E Darris, Sergei V Chetyrkin, Vadim K Pedchenko, Sergei P Boudko, Kyle L Brown, W Gray Jerome, Julie K Hudson, Antonis Rokas, Billy G Hudson
The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collagens, of non-bilaterian animal phyla. We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and Bilateria...
April 18, 2017: ELife
https://www.readbyqxmd.com/read/28408660/a-global-coexpression-network-approach-for-connecting-genes-to-specialized-metabolic-pathways-in-plants
#5
Jennifer H Wisecaver, Alexander T Borowsky, Vered Tzin, Georg Jander, Daniel J Kliebenstein, Antonis Rokas
Plants produce diverse specialized metabolites (SMs), but the genes responsible for their production and regulation remain largely unknown, hindering efforts to tap plant pharmacopeia. Given that genes comprising SM pathways exhibit environmentally dependent coregulation, we hypothesized that genes within a SM pathway would form tight associations (modules) with each other in coexpression networks, facilitating their identification. To evaluate this hypothesis, we used 10 global coexpression data sets, each a meta-analysis of hundreds to thousands of experiments, across eight plant species to identify hundreds of coexpressed gene modules per data set...
May 2017: Plant Cell
https://www.readbyqxmd.com/read/28380923/ultrafast-laser-induced-birefringence-in-various-porosity-silica-glasses-from-fused-silica-to-aerogel
#6
Ausra Cerkauskaite, Rokas Drevinskas, Alexey O Rybaltovskii, Peter G Kazansky
We compare a femtosecond laser induced modification in silica matrices with three different degrees of porosity. In single pulse regime, the decrease of substrate density from fused silica to high-silica porous glass and to silica aerogel glass results in tenfold increase of laser affected region with the formation of a symmetric cavity surrounded by the compressed silica shell with pearl like structures. In multi-pulse regime, if the cavity produced by the first pulse is relatively large, the subsequent pulses do not cause further modifications...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28379347/large-multiple-tuberous-xanthomas-presenting-with-severe-coronary-artery-disease
#7
Arun Maskey, Anish Hirachan, Dharmanath Yadav, Madhu Roka
No abstract text is available yet for this article.
March 31, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28339581/rationale-and-design-of-the-budapest-crt-upgrade-study-a-prospective-randomized-multicentre-clinical-trial
#8
Bela Merkely, Annamaria Kosztin, Attila Roka, Laszlo Geller, Endre Zima, Attila Kovacs, Andras Mihaly Boros, Helmut Klein, Jerzy K Wranicz, Gerhard Hindricks, Marcell Clemens, Gabor Z Duray, Arthur J Moss, Ilan Goldenberg, Valentina Kutyifa
Aims: There is lack of conclusive evidence from randomized clinical trials on the efficacy and safety of upgrade to cardiac resynchronization therapy (CRT) in patients with implanted pacemakers (PM) or defibrillators (ICD) with reduced left ventricular ejection fraction (LVEF) and chronic heart failure (HF). The BUDAPEST-CRT Upgrade Study was designed to compare the efficacy and safety of CRT upgrade from conventional PM or ICD therapy in patients with intermittent or permanent right ventricular (RV) septal/apical pacing, reduced LVEF, and symptomatic HF...
October 6, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28292787/extensive-copy-number-variation-in-fermentation-related-genes-among-saccharomyces-cerevisiae-wine-strains
#9
Jacob Steenwyk, Antonis Rokas
Due to the importance of Saccharomyces cerevisiae in wine-making, the genomic variation of wine yeast strains has been extensively studied. One of the major insights stemming from these studies is that wine yeast strains harbor low levels of genetic diversity in the form of single nucleotide polymorphisms (SNPs). Genomic structural variants, such as copy number (CN) variants, are another major type of variation segregating in natural populations. To test whether genetic diversity in CN variation is also low across wine yeast strains, we examined genome-wide levels of CN variation in 132 whole-genome sequences of S...
May 5, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28222284/mammalian-pregnancy
#10
Patrick Abbot, Antonis Rokas
Patrick Abbot & Antonis Rokas introduce the biology of pregnancy in mammals.
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28103316/alpha-melanocyte-stimulating-hormone-protects-against-cytokine-induced-barrier-damage-in-caco-2-intestinal-epithelial-monolayers
#11
Judit Váradi, András Harazin, Ferenc Fenyvesi, Katalin Réti-Nagy, Péter Gogolák, György Vámosi, Ildikó Bácskay, Pálma Fehér, Zoltán Ujhelyi, Gábor Vasvári, Eszter Róka, David Haines, Mária A Deli, Miklós Vecsernyés
Alpha-melanocyte-stimulating hormone (α-MSH) is a potent anti-inflammatory peptide with cytoprotective effect in various tissues. The present investigation demonstrates the ability of α-MSH to interact with intestinal epithelial cell monolayers and mitigate inflammatory processes of the epithelial barrier. The protective effect of α-MSH was studied on Caco-2 human intestinal epithelial monolayers, which were disrupted by exposure to tumor necrosis factor-α and interleukin-1β. The barrier integrity was assessed by measuring transepithelial electric resistance (TEER) and permeability for marker molecules...
2017: PloS One
https://www.readbyqxmd.com/read/28007975/ctdgfinder-a-novel-homology-based-algorithm-for-identifying-closely-spaced-clusters-of-tandemly-duplicated-genes
#12
Juan F Ortiz, Antonis Rokas
Closely spaced clusters of tandemly duplicated genes (CTDGs) contribute to the diversity of many phenotypes, including chemosensation, snake venom, and animal body plans. CTDGs have traditionally been identified subjectively as genomic neighborhoods containing several gene duplicates in close proximity; however, CTDGs are often highly variable with respect to gene number, intergenic distance, and synteny. This lack of formal definition hampers the study of CTDG evolutionary dynamics and the discovery of novel CTDGs in the exponentially growing body of genomic data...
October 20, 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/27892489/laser-light-induced-transformation-of-molybdenum-disulphide-based-nanoplatelet-arrays
#13
Arūnas Jagminas, Gediminas Niaura, Rokas Žalnėravičius, Romualdas Trusovas, Gediminas Račiukaitis, Vitalija Jasulaitiene
One-pot hydrothermal synthesis of MoS2 nanoplatelet arrays on various substrates is perhaps the most promising approach to fabricate efficient electrocatalysts for hydrogen evolution reaction. However, the main challenges in this synthesis remain the purity and crystallinity of MoS2. In this study, we show for the first time that irradiation of amorphous, defect-rich MoS2 nanoplatelets with a green nanosecond laser at a proper irradiation dose, ca ≤0.35 J cm(-2), can significantly improve the crystallinity and purity of MoS2 nanoplatelets...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27886934/coronary-sinus-lead-positioning
#14
REVIEW
Attila Roka, Rasmus Borgquist, Jagmeet Singh
Although cardiac resynchronization therapy improves morbidity and mortality in patients with cardiomyopathy, heart failure, and electrical dyssynchrony, the rate of nonresponders using standard indications and implant techniques is still high. Optimal coronary sinus lead positioning is important to increase the chance of successful resynchronization. Patient factors such as cause of heart failure, type of dyssynchrony, scar burden, coronary sinus anatomy, and phrenic nerve capture may affect the efficacy of the therapy...
January 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/27845382/effect-of-bio-engineering-on-size-shape-composition-and-rigidity-of-bacterial-microcompartments
#15
Matthias J Mayer, Rokas Juodeikis, Ian R Brown, Stefanie Frank, David J Palmer, Evelyne Deery, David M Beal, Wei-Feng Xue, Martin J Warren
Bacterial microcompartments (BMCs) are proteinaceous organelles that are found in a broad range of bacteria and are composed of an outer shell that encases an enzyme cargo representing a specific metabolic process. The outer shell is made from a number of different proteins that form hexameric and pentameric tiles, which interact to allow the formation of a polyhedral edifice. We have previously shown that the Citrobacter freundii BMC associated with 1,2-propanediol utilization can be transferred into Escherichia coli to generate a recombinant BMC and that empty BMCs can be formed from just the shell proteins alone...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27795893/genetic-assessment-of-captive-red-panda-ailurus-fulgens-population
#16
Arun Kumar, Upashna Rai, Bhupen Roka, Alankar K Jha, P Anuradha Reddy
Red panda (Ailurus fulgens) is threatened across its range by detrimental human activities and rapid habitat changes necessitating captive breeding programs in various zoos globally to save this flagship species from extinction. One of the ultimate aims of ex situ conservation is reintroduction of endangered animals into their natural habitats while maintaining 90 % of the founder genetic diversity. Advances in molecular genetics and microsatellite genotyping techniques make it possible to accurately estimate genetic diversity of captive animals of unknown ancestry...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27794353/relative-acoustic-frequency-response-of-induced-methane-carbon-dioxide-and-air-gas-bubble-plumes-observed-laterally
#17
Rokas Kubilius, Geir Pedersen
There is an increased need to detect, identify, and monitor natural and manmade seabed gas leaks. Fisheries echosounders are well suited to monitor large volumes of water and acoustic frequency response [normalized acoustic backscatter, when a measure at one selected frequency is used as a denominator, r(f)] is commonly used to identify echoes from fish and zooplankton species. Information on gas plume r(f) would be valuable for automatic detection of subsea leaks and for separating bubble plumes from natural targets such as swimbladder-bearing fish...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27785347/sex-and-gender-in-medical-education-a-national-student-survey
#18
Marjorie R Jenkins, Alyssa Herrmann, Amanda Tashjian, Tina Ramineni, Rithika Ramakrishnan, Donna Raef, Tracy Rokas, John Shatzer
BACKGROUND: Gender- and sex-specific medicine is defined as the practice of medicine based on the understanding that biology (dictated by sex chromosomes) and social roles (gender) are important in and have implications for prevention, screening, diagnosis, and treatment in men and women. In light of the many ways that sex and gender influence disease presentation and patient management, there have been various initiatives to improve the integration of these topics into medical education curriculum...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27746117/sentinel-lymph-node-biopsy-for-high-risk-cutaneous-squamous-cell-carcinoma-analysis-of-recurrence-free-survival
#19
Donatas Samsanavičius, Vygintas Kaikaris, Simonas-Jonas Norvydas, Rokas Liubauskas, Skaidra Valiukevičienė, Jurgita Makštienė, Kęstutis Maslauskas, Rytis Rimdeika
BACKGROUND AND AIM: Cutaneous squamous cell carcinoma (CSCC) is a malignant epithelial cell tumor. CSCC has a tendency to spread via lymphogenic pathway. Metastases are found in 2%-6% of cases. Prognosis of patients with CSCC is directly related to the morphology and localization of primary tumor. The aim of this study was to evaluate the recurrence-free survival of patients with CSCC after tumor excision and SLNB as well as to analyze morphologic CSCC features related to patient recurrence-free survival...
2016: Medicina
https://www.readbyqxmd.com/read/27694115/regulation-of-secondary-metabolism-by-the-velvet-complex-is-temperature-responsive-in-aspergillus
#20
Abigail L Lind, Timothy D Smith, Timothy Saterlee, Ana M Calvo, Antonis Rokas
Sensing and responding to environmental cues is critical to the lifestyle of filamentous fungi. How environmental variation influences fungi to produce a wide diversity of ecologically important secondary metabolites (SMs) is not well understood. To address this question, we first examined changes in global gene expression of the opportunistic human pathogen, Aspergillus fumigatus, after exposure to different temperature conditions. We found that 11 of the 37 SM gene clusters in A. fumigatus were expressed at higher levels at 30° than at 37°...
December 7, 2016: G3: Genes—Genomes—Genetics
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