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https://www.readbyqxmd.com/read/29149178/drivers-of-genetic-diversity-in-secondary-metabolic-gene-clusters-within-a-fungal-species
#1
Abigail L Lind, Jennifer H Wisecaver, Catarina Lameiras, Philipp Wiemann, Jonathan M Palmer, Nancy P Keller, Fernando Rodrigues, Gustavo H Goldman, Antonis Rokas
Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for defense, virulence, and communication. The metabolic pathways that produce SMs are found in contiguous gene clusters in fungal genomes, an atypical arrangement for metabolic pathways in other eukaryotes. Comparative studies of filamentous fungal species have shown that SM gene clusters are often either highly divergent or uniquely present in one or a handful of species, hampering efforts to determine the genetic basis and evolutionary drivers of SM gene cluster divergence...
November 17, 2017: PLoS Biology
https://www.readbyqxmd.com/read/29054852/selective-base-excision-repair-of-dna-damage-by-the-non-base-flipping-dna-glycosylase-alkc
#2
Rongxin Shi, Elwood A Mullins, Xing-Xing Shen, Kori T Lay, Philip K Yuen, Sheila S David, Antonis Rokas, Brandt F Eichman
DNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications, and thus, the mechanisms by which glycosylases locate DNA damage are of particular interest. Bacterial AlkC and AlkD are specific for cationic alkylated nucleobases and have a distinctive HEAT-like repeat (HLR) fold. AlkD uses a unique non-base-flipping mechanism that enables excision of bulky lesions more commonly associated with nucleotide excision repair. In contrast, AlkC has a much narrower specificity for small lesions, principally N3-methyladenine (3mA)...
October 20, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29040489/palliation-of-anastomotic-tumor-recurrence-after-esophagectomy-and-gastric-transposition-cervico-mediastinal-resection-and-reconstruction-by-using-a-free-jejunal-transplant
#3
M Hermann, H Piza-Katzer, A Leitgeb, S Roka, R Roka
No abstract text is available yet for this article.
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29017048/embracing-uncertainty-in-reconstructing-early-animal-evolution
#4
REVIEW
Nicole King, Antonis Rokas
The origin of animals, one of the major transitions in evolution, remains mysterious. Many key aspects of animal evolution can be reconstructed by comparing living species within a robust phylogenetic framework. However, uncertainty remains regarding the evolutionary relationships between two ancient animal lineages - sponges and ctenophores - and the remaining animal phyla. Comparative morphology and some phylogenomic analyses support the view that sponges represent the sister lineage to the rest of the animals, while other phylogenomic analyses support ctenophores, a phylum of carnivorous, gelatinous marine organisms, as the sister lineage...
October 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28994317/isolated-cervical-anterior-spinal-artery-aneurysm-case-report
#5
Yam Bahadur Roka
Isolated cervical anterior spinal artery (CASA) aneurysms are extremely rare with most of them mostly associated with arteriovenous malformation. The underlying pathology is not known but some factors leading to the aneurysm are inflammatory, infection and connective tissue disorders. Trauma with formation of pseudoaneurysm has also been reported. We report a case which presented with fourth ventricle bleed and was managed successfully with conservative treatment.
October 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28967492/multimorbidity-care-model-recommendations-from-the-consensus-meeting-of-the-joint-action-on-chronic-diseases-and-promoting-healthy-ageing-across-the-life-cycle-ja-chrodis
#6
Katie Palmer, Alessandra Marengoni, Maria João Forjaz, Elena Jureviciene, Tiina Laatikainen, Federica Mammarella, Christiane Muth, Rokas Navickas, Alexandra Prados-Torres, Mieke Rijken, Ulrike Rothe, Laurène Souchet, Jose Valderas, Theodore Vontetsianos, Jelka Zaletel, Graziano Onder
Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful clinical interventions. There is limited evidence on available integrated and multidimensional care pathways for multimorbid patients. An expert consensus meeting was held to develop a framework for care of multimorbid patients that can be applied across Europe, within a project funded by the European Union; the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS)...
September 14, 2017: Health Policy
https://www.readbyqxmd.com/read/28922030/rapid-detection-and-classification-of-salmonella-enterica-shedding-in-feedlot-cattle-utilizing-the-roka-bioscience-atlas-salmonella-detection-assay-for-the-analysis-of-rectoanal-mucosal-swabs
#7
W Evan Chaney, Getahun E Agga, Scott V Nguyen, Terrance M Arthur, Joseph M Bosilevac, Erin Dreyling, Anantharama Rishi, Dayna Brichta-Harhay
With an increasing focus on preharvest food safety, rapid methods are required for the detection and quantification of foodborne pathogens such as Salmonella enterica in beef cattle. We validated the Atlas Salmonella Detection Assay (SEN), a nucleic acid amplification technology that targets Salmonella rRNA, for the qualitative detection of S. enterica with sample enrichment using immunomagnetic separation as a reference test, and we further evaluated its accuracy to predict pathogen load using SEN signal-to-cutoff (SCO) values from unenriched samples to classify animals as high or nonhigh shedders...
October 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28903758/factors-associated-with-malaria-microscopy-diagnostic-performance-following-a-pilot-quality-assurance-programme-in-health-facilities-in-malaria-low-transmission-areas-of-kenya-2014
#8
Fredrick Odhiambo, Ann M Buff, Collins Moranga, Caroline M Moseti, Jesca Okwara Wesongah, Sara A Lowther, Wences Arvelo, Tura Galgalo, Thomas O Achia, Zeinab G Roka, Waqo Boru, Lily Chepkurui, Bernhards Ogutu, Elizabeth Wanja
BACKGROUND: Malaria accounts for ~21% of outpatient visits annually in Kenya; prompt and accurate malaria diagnosis is critical to ensure proper treatment. In 2013, formal malaria microscopy refresher training for microscopists and a pilot quality-assurance (QA) programme for malaria diagnostics were independently implemented to improve malaria microscopy diagnosis in malaria low-transmission areas of Kenya. A study was conducted to identify factors associated with malaria microscopy performance in the same areas...
September 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28864036/aerobic-training-effect-on-arterial-stiffness-in-metabolic-syndrome
#9
Ieva Slivovskaja, Ligita Ryliskyte, Pranas Serpytis, Rokas Navickas, Jolita Badarienė, Jelena Celutkiene, Roma Puronaite, Kristina Ryliskiene, Alma Cypiene, Egidija Rinkuniene, Vaida Sileikiene, Birute Petrauskiene, Alvydas Juocevicius, Aleksandras Laucevicius
BACKGROUND: Metabolic syndrome, physical inactivity and central obesity contribute to early vascular aging, which leads to increased risk of cardiovascular disease. The study aimed to assess the effect of heart rate (HR) targeted aerobic exercise training on the indices of early vascular aging, in particular, arterial stiffness, and on anthropometric and clinical profile of metabolic syndrome subjects. METHODS: 126 metabolic syndrome subjects were randomly selected...
August 29, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28864013/the-transformative-potential-of-an-integrative-approach-to-pregnancy
#10
Haley R Eidem, Kriston L McGary, John A Capra, Patrick Abbot, Antonis Rokas
BACKGROUND: Complex traits typically involve diverse biological pathways and are shaped by numerous genetic and environmental factors. Pregnancy-associated traits and pathologies are further complicated by extensive communication across multiple tissues in two individuals, interactions between two genomes-maternal and fetal-that obscure causal variants and lead to genetic conflict, and rapid evolution of pregnancy-associated traits across mammals and in the human lineage. Given the multi-faceted complexity of human pregnancy, integrative approaches that synthesize diverse data types and analyses harbor tremendous promise to identify the genetic architecture and environmental influences underlying pregnancy-associated traits and pathologies...
September 2017: Placenta
https://www.readbyqxmd.com/read/28859699/method-modification-for-the-atlas-listeria-environmental-le-detection-assay-using-foodchek-actero-listeria-enrichment-media-and-half-fraser-media-for-the-detection-of-listeria-spp-from-environmental-surfaces
#11
Brett Maroni, Tucker Lopez, Cambria Neal, Sarah Verver, Celina Puente, Jannelle Lauffer, Joseph Garcia, Bettina Groschel, Erin Dreyling, W Evan Chaney, Ben Bastin, Patrick Bird, M Joseph Benzinger, James Agin, David Goins, Upasana Hariram, Yi Chen, Elliot Ryser, Michael Brodsky
Two candidate method modifications for the Atlas Listeria Environmental LE Detection Assay were compared with the U.S. Department of Agriculture (USDA)-Food Safety and Inspection Service Microbiology Laboratory Guidebook 8.09 (MLG 8.09) method for detection of Listeria spp. on stainless steel, polyvinyl chloride (PVC), and sealed concrete surfaces. For LE candidate method 1, samples were enriched in FoodChek Actero Listeria Enrichment Media [ALEM; Performance Tested Method(SM) (PTM) 111201] at 35 ± 2°C for 18 to 24 h and evaluated for a range of analytical sample volumes...
August 31, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28829287/correction-%C3%A2-heredity-the-gene-family-that-cheats-mendel
#12
J Dylan Shropshire, Antonis Rokas
No abstract text is available yet for this article.
August 22, 2017: ELife
https://www.readbyqxmd.com/read/28815214/chlamydomonas-reinhardtii-lfo1-is-an-isdg-family-heme-oxygenase
#13
Lisa J Lojek, Allison J Farrand, Jennifer H Wisecaver, Crysten E Blaby-Haas, Brian W Michel, Sabeeha S Merchant, Antonis Rokas, Eric P Skaar
Heme is essential for respiration across all domains of life. However, heme accumulation can lead to toxicity if cells are unable to either degrade or export heme or its toxic by-products. Under aerobic conditions, heme degradation is performed by heme oxygenases, enzymes which utilize oxygen to cleave the tetrapyrrole ring of heme. The HO-1 family of heme oxygenases has been identified in both bacterial and eukaryotic cells, whereas the IsdG family has thus far been described only in bacteria. We identified a hypothetical protein in the eukaryotic green alga Chlamydomonas reinhardtii, which encodes a protein containing an antibiotic biosynthesis monooxygenase (ABM) domain consistent with those associated with IsdG family members...
July 2017: MSphere
https://www.readbyqxmd.com/read/28812701/contentious-relationships-in-phylogenomic-studies-can-be-driven-by-a-handful-of-genes
#14
Xing-Xing Shen, Chris Todd Hittinger, Antonis Rokas
Phylogenomic studies have resolved countless branches of the tree of life, but remain strongly contradictory on certain, contentious relationships. Here, we use a maximum likelihood framework to quantify the distribution of phylogenetic signal among genes and sites for 17 contentious branches and 6 well-established control branches in plant, animal and fungal phylogenomic data matrices. We find that resolution in some of these 17 branches rests on a single gene or a few sites, and that removal of a single gene in concatenation analyses or a single site from every gene in coalescence-based analyses diminishes support and can alter the inferred topology...
April 10, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28800687/the-profound-effect-of-harmful-cyanobacterial-blooms-from-food-web-and-management-perspectives
#15
Sigitas Šulčius, Danguolė Montvydienė, Hanna Mazur-Marzec, Jūratė Kasperovičienė, Rokas Rulevičius, Živilė Cibulskaitė
Sustainable and effective water management plans must have a reliable risk assessment strategies for harmful cyanobacterial blooms (HABs) that would enable timely decisions to be made, thus avoiding the trespassing of ecological thresholds, leading to the collapse of ecosystem structure and function. Such strategies are usually based on cyanobacterial biomass and/or on the monitoring of known toxins, which may, however, in many cases, under- or over-represent the actual toxicity of the HAB. Therefore, in this study, by the application of growth-inhibition assays using different bacteria, algae, zooplankton and fish species, we assessed the toxicological potential of two cyanobacterial blooms that differed in total cyanobacterial biomass, species composition and cyanopeptide profiles...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28782246/the-surgical-anatomy-of-the-vascularized-lateral-thoracic-artery-lymph-node-flap-a-cadaver-study
#16
Ines E Tinhofer, Stefan Meng, Johannes Steinbacher, Julia Roka-Palkovits, Eva Györi, Lukas F Reissig, Ming-Huei Cheng, Wolfgang J Weninger, Chieh-Han J Tzou
BACKGROUND: One promising surgical treatment of lymphedema is the VLNT. Lymph nodes can be harvested from different locations; inguinal, axillary, and supraclavicular ones are used most often. The aim of our study was to assess the surgical anatomy of the lateral thoracic artery lymph node flap. MATERIALS AND METHODS: In total, 16 lymph node flaps from nine cadavers were dissected. Flap markings were made between the anterior and posterior axillary line in dimensions of 10 × 5 cm...
August 7, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28720755/functional-variants-of-the-melanocortin-4-receptor-associated-with-the-odontoceti-and-mysticeti-suborders-of-cetaceans
#17
Liyuan Zhao, Xiaofan Zhou, Antonis Rokas, Roger D Cone
Cetaceans, a group of mammals adapted to the aquatic environment that descended from terrestrial artiodactyls, exhibit tremendous interspecific differences in a number of phenotypes, including feeding behavior, such as filter feeding in the Mysticeti vs prey-hunting Odontoceti, and size, with the smallest cetacean, the vaquita, at 1.4 meters and the largest, the blue whale, reaching 33 meters. The Melanocortin-4 receptor (MC4R) regulates food intake, energy balance, and somatic growth in both mammals and teleosts...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715077/age-and-gender-related-peculiarities-of-patients-with-delirium-in-the-cardiac-intensive-care-unit
#18
Pranas Serpytis, Petras Navickas, Alvydas Navickas, Rokas Serpytis, Giedrius Navickas, Sigita Glaveckaite
BACKGROUND: The overall evidence base regarding delirium has been growing steadily over the past few decades. There has been considerable analysis of delirium concerning, for example, mechanically ventilated patients, patients in the general intensive care unit (ICU) setting, and patients with exclusively postoperative delirium. Nevertheless, there are few studies regarding delirium in a cardiovascular ICU (ICCU) setting and especially scarce literature about the particular features of delirium relating to patient age and gender...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714722/pilot-testing-the-daily-activities-list-for-inmates-dali-item-evaluation-and-content-validity
#19
Philip R Magaletta, Rokas Perskaudas, Christina J Connors, Marc W Patry, Jarrod Reisweber, Alix McLearen
Scheduling enjoyable daily activities is a Cognitive Behavioral Therapy intervention used in the treatment of depression and substance abuse disorders that are prevalent disorders among inmates. To effectively use this intervention with inmates, an activities list with items ecologically sensitive to the correctional setting needs to be created. The purpose of this study was to develop and evaluate items; thus, establishing a content valid Daily Activities List for Inmates (DALI). Fifteen corrections professionals representing a wide range of disciplines and managerial backgrounds served as subject matter experts (SMEs)...
July 17, 2017: Psychological Services
https://www.readbyqxmd.com/read/28691723/effect-of-ethanol-on-the-visual-evoked-potential-in-rat-dynamics-of-on-and-off-responses
#20
Redas Dulinskas, Rokas Buisas, Valentina Vengeliene, Osvaldas Ruksenas
The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute administration of ethanol...
2017: Acta Neurobiologiae Experimentalis
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