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Anastasia Vlachou, Panayiota Stavroussi, Olga Roka, Evdokia Vasilou, Dimitra Papadimitriou, Chiara Scaratti, Asel Kadyrbaeva, Klemens Fheodoroff, Valentina Brecelj, Olga Svestkova, Beata Tobiasz-Adamczyk, Jon Erik Finnvold, Sonja Gruber, Matilde Leonardi
The increasing prevalence of chronic diseases among the European working age population, as well as the implications for the individual and societal level, underline the need for policy guidelines targeting the effective inclusion of persons with chronic diseases in the workplace. The aim of the present paper was to explore the perspectives of European and National-level stakeholders on existing strategies for work re-integration of persons with chronic diseases, and to provide policy guidelines. A highly-structured interview protocol was distributed to 58 National level stakeholders (policy makers, professionals and employers) from seven European countries...
March 11, 2018: International Journal of Environmental Research and Public Health
Guy Rozen, Jeena Vaid, Seyed Mohammadreza Hosseini, M Ihsan Kaadan, Allon Rafael, Attila Roka, Yukkee C Poh, Ming-Zher Poh, Edwin Kevin Heist, Jeremy Neil Ruskin
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults, associated with significant morbidity, increased mortality, and rising health-care costs. Simple and available tools for the accurate detection of arrhythmia recurrence in patients after electrical cardioversion (CV) or ablation procedures for AF can help to guide therapeutic decisions. We conducted a prospective, single-center study to evaluate the accuracy of Cardiio Rhythm Mobile Application (CRMA) for AF detection. Patients >18 years of age who were scheduled for elective CV for AF were enrolled in the study...
February 13, 2018: American Journal of Cardiology
Jacob L Steenwyk, Antonis Rokas
In recent years, copy number (CN) variation has emerged as a new and significant source of genetic polymorphisms contributing to the phenotypic diversity of populations. CN variants are defined as genetic loci that, due to duplication and deletion, vary in their number of copies across individuals in a population. CN variants range in size from 50 base pairs to whole chromosomes, can influence gene activity, and are associated with a wide range of phenotypes in diverse organisms, including the budding yeast Saccharomyces cerevisiae ...
2018: Frontiers in Microbiology
Dana A Opulente, Emily J Rollinson, Cleome Bernick-Roehr, Amanda Beth Hulfachor, Antonis Rokas, Cletus P Kurtzman, Chris Todd Hittinger
BACKGROUND: Associations between traits are prevalent in nature, occurring across a diverse range of taxa and traits. Individual traits may co-evolve with one other, and these correlations can be driven by factors intrinsic or extrinsic to an organism. However, few studies, especially in microbes, have simultaneously investigated both across a broad taxonomic range. Here we quantify pairwise associations among 48 traits across 784 diverse yeast species of the ancient budding yeast subphylum Saccharomycotina, assessing the effects of phylogenetic history, genetics, and ecology...
March 2, 2018: BMC Biology
Paulius Toliusis, Giedre Tamulaitiene, Rokas Grigaitis, Donata Tuminauskaite, Arunas Silanskas, Elena Manakova, Ceslovas Venclovas, Mark D Szczelkun, Virginijus Siksnys, Mindaugas Zaremba
CglI is a restriction endonuclease from Corynebacterium glutamicum that forms a complex between: two R-subunits that have site specific-recognition and nuclease domains; and two H-subunits, with Superfamily 2 helicase-like DEAD domains, and uncharacterized Z1 and C-terminal domains. ATP hydrolysis by the H-subunits catalyses dsDNA translocation that is necessary for long-range movement along DNA that activates nuclease activity. Here, we provide biochemical and molecular modelling evidence that shows that Z1 has a fold distantly-related to RecA, and that the DEAD-Z1 domains together form an ATP binding interface and are the prototype of a previously undescribed monomeric helicase-like motor...
February 20, 2018: Nucleic Acids Research
Jiyun M Moon, David M Aronoff, John A Capra, Patrick Abbot, Antonis Rokas
Sialic acids are nine carbon sugars ubiquitously found on the surfaces of vertebrate cells and are involved in various immune response-related processes. In humans, at least 58 genes spanning diverse functions, from biosynthesis and activation to recycling and degradation, are involved in sialic acid biology. Because of their role in immunity, sialic acid biology genes have been hypothesized to exhibit elevated rates of evolutionary change. Consistent with this hypothesis, several genes involved in sialic acid biology have experienced higher rates of non-synonymous substitutions in the human lineage than their counterparts in other great apes, perhaps in response to ancient pathogens that infected hominins millions of years ago (paleopathogens)...
February 21, 2018: G3: Genes—Genomes—Genetics
Rimtautas Gudas, Rokas Jurkonis, Alfredas Smailys
BACKGROUND The aim of this study was to evaluate the reconstruction of a torn anterior cruciate ligament (ACL) with 10 mm diameter BPTB (bone-patellar tendon-bone) autograft versus 8 mm HT (hamstring tendon) autografts, to compare the ability to restore pre-injury sports activities and reduce revision risk after these procedures. MATERIAL AND METHODS A prospective clinical review was performed to compare results of patients who underwent primary anatomical ACLR with 10 mm BPTB autografts with patients who underwent 8 mm diameter HT autografts, between January 2011 and January 2014...
February 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Rokas Serpytis, Aurelija Navickaite, Emilija Serpytiene, Jurate Barysiene, Germanas Marinskis, Dalius Jatuzis, Zaneta Petrulioniene, Aleksandras Laucevicius, Pranas Serpytis
OBJECTIVE: Atrial fibrillation is the most common cardiac arrhythmia and a known risk factor for cerebrovascular stroke. Atrial fibrillation and long standing hypertension may produce ischemic lesions leading to progressive cognitive impairment. The impact of atrial fibrillation alone on cognitive impairment has not been evaluated. Our objective was to compare cognitive function, quality of life, psychological distress and impulsiveness in people with atrial fibrillation and a matched control group...
January 30, 2018: American Journal of Medicine
Juozas Dudutis, Rokas Stonys, Gediminas Račiukaitis, Paulius Gečys
It is known that Bessel beam generation with a non-ideal axicon induces beam pattern distortions. In this paper, we introduce a simple method for non-ideal axicon-generated Bessel beam reconstruction by tilting the axicon perpendicular to its optical axis. We found an optimum axicon tilt angle where beam distortions can be compensated by inducing additional astigmatic aberrations. At optimal tilt angle, the central spot symmetry and focal depth was increased. By this method we could control crack formation symmetry in the bulk of glass, which is essential for many transparent material processing applications...
February 5, 2018: Optics Express
Soo-Ha Kwon, Che-Hsiung Lee, Angela Ting-Wei Hsu, Mark Shafarenko, Usama Farghaly Omar, Chieh-Han John Tzou, Julia Roka-Palkovits, Aldo G Beltrán P, Dimitri Liakos, Tommy Nai-Jen Chang
BACKGROUND: The best reconstructive strategy for upper lip defects is still in debate. The purpose of this study was to analyze the decisions made by international microsurgeons, who were participated through online questionnaire, distributed by email and social media network. MATERIALS AND METHODS: A case of a two-thirds upper lip oncologic defect was presented via an online questionnaire and 402 microsurgeons replied their treatment options. The data were then analyzed according to the geographic area, microsurgical fellowship, seniority, and subspecialty...
February 2, 2018: Journal of Reconstructive Microsurgery
Ugonna C Ijeoma, Sin Sansam, Sok Srun, Hoy Vannara, Sou Sanith, Tek Sopheap, Robert D Newman, Renuka Gadde, Selenic Dejana, Ahmed Saadani Hassani, Vanthy Ly, Bakary Drammeh, Anindya De, Johnita Byrd, Naomi Bock
No abstract text is available yet for this article.
February 2, 2018: MMWR. Morbidity and Mortality Weekly Report
Abdelhamid Nacereddine, Andre Bollacke, Eszter Róka, Christelle Marminon, Zouhair Bouaziz, Ferenc Fenyvesi, Ildikó Katalin Bácskay, Joachim Jose, Florent Perret, Marc Le Borgne
Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2 (CK2) is of great interest and numerous scaffolds have been investigated to design CK2 inhibitors. Recently, functionalized indeno[1,2-b]indoles have been revealed to have high potency against human cancer cell lines such as MCF-7 breast carcinoma and A-427 lung carcinoma. 4-Methoxy-5-isopropyl-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione (THN7), identified as a potent inhibitor of CK2 (IC50 = 71 nM), was selected for an encapsulation study in order to evaluate its antiproliferative activity as THN7-loaded cyclodextrin nanoparticles...
January 26, 2018: Pharmaceuticals
Claire Adams Spears, Sean C Houchins, Wendy P Bamatter, Sandra Barrueco, Diana Stewart Hoover, Rokas Perskaudas
Individuals with low socioeconomic status (SES) and members of racial/ethnic minority groups often experience profound disparities in mental health and physical well-being. Mindfulness-based interventions show promise for improving mood and health behaviors in higher-SES and non-Latino White populations. However, research is needed to explore what types of adaptations, if any, are needed to best support underserved populations. This study used qualitative methods to gain information about a) perceptions of mindfulness, b) experiences with meditation, c) barriers to practicing mindfulness, and d) recommendations for tailoring mindfulness-based interventions in a low-income, primarily African American treatment-seeking sample...
December 2017: Mindfulness
François Rouet, Janin Nouhin, Du-Ping Zheng, Benjamin Roche, Allison Black, Sophearot Prak, Marie Leoz, Catherine Gaudy-Graffin, Laurent Ferradini, Chandara Mom, Sovatha Mam, Charlotte Gautier, Gérard Lesage, Sreymom Ken, Kerya Phon, Alexandra Kerleguer, Chunfu Yang, William Killam, Masami Fujita, Chhivun Mean, Didier Fontenille, Francis Barin, Jean-Christophe Plantier, Trevor Bedford, Artur Ramos, Vonthanak Saphonn
Background: In 2014-2015, 242 individuals aged 2-89 were newly HIV-1 diagnosed in Roka, a rural commune in Cambodia. A case-control study attributed the outbreak to unsafe injections. We aimed to reconstruct the likely transmission history of the outbreak. Methods: We assessed in 209 (86.4%) HIV-infected cases the presence of hepatitis C and B viruses (HCV, HBV). We identified recent infections using antibody (Ab) avidity testing for HIV and HCV, and HBcIgM Ab for HBV...
December 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Sofia Chatzidou, Evangelos Repasos, Sotiris Plastiras, Christos Kontogiannis, Marinos Kosmopoulos, Diamantis I Tsilimigras, Ioannis Paraskevaidis, Stelios Rokas
Early repolarization syndrome (ERS) was originally considered a normal variant with benign outcome. However, recent studies have demonstrated that it can be linked to a considerable risk of life-threatening arrhythmias and sudden cardiac death. We report a case with an extraordinary, extremely malignant clinical expression of ERS refractory to all antiarrhythmic drugs including quinidine. This case demonstrates real-time changes of dynamic electrocardiogram (ECG) preceding a polymorphic ventricular tachycardia (VT)-ventricular fibrillation (VF) and possible external factors triggering arrhythmia onset...
December 5, 2017: Annals of Noninvasive Electrocardiology
Xiaofan Zhou, Xing-Xing Shen, Chris Todd Hittinger, Antonis Rokas
The sizes of the data matrices assembled to resolve branches of the tree of life have increased dramatically, motivating the development of programs for fast, yet accurate, inference. For example, several different fast programs have been developed in the very popular maximum likelihood framework, including RAxML/ExaML, PhyML, IQ-TREE, and FastTree. Although these programs are widely used, a systematic evaluation and comparison of their performance using empirical genome-scale data matrices has so far been lacking...
February 1, 2018: Molecular Biology and Evolution
Abigail L Lind, Jennifer H Wisecaver, Catarina Lameiras, Philipp Wiemann, Jonathan M Palmer, Nancy P Keller, Fernando Rodrigues, Gustavo H Goldman, Antonis Rokas
Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for defense, virulence, and communication. The metabolic pathways that produce SMs are found in contiguous gene clusters in fungal genomes, an atypical arrangement for metabolic pathways in other eukaryotes. Comparative studies of filamentous fungal species have shown that SM gene clusters are often either highly divergent or uniquely present in one or a handful of species, hampering efforts to determine the genetic basis and evolutionary drivers of SM gene cluster divergence...
November 2017: PLoS Biology
Rongxin Shi, Elwood A Mullins, Xing-Xing Shen, Kori T Lay, Philip K Yuen, Sheila S David, Antonis Rokas, Brandt F Eichman
DNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications, and thus, the mechanisms by which glycosylases locate DNA damage are of particular interest. Bacterial AlkC and AlkD are specific for cationic alkylated nucleobases and have a distinctive HEAT-like repeat (HLR) fold. AlkD uses a unique non-base-flipping mechanism that enables excision of bulky lesions more commonly associated with nucleotide excision repair. In contrast, AlkC has a much narrower specificity for small lesions, principally N3-methyladenine (3mA)...
October 20, 2017: EMBO Journal
M Hermann, H Piza-Katzer, A Leitgeb, S Roka, R Roka
No abstract text is available yet for this article.
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Nicole King, Antonis Rokas
The origin of animals, one of the major transitions in evolution, remains mysterious. Many key aspects of animal evolution can be reconstructed by comparing living species within a robust phylogenetic framework. However, uncertainty remains regarding the evolutionary relationships between two ancient animal lineages - sponges and ctenophores - and the remaining animal phyla. Comparative morphology and some phylogenomic analyses support the view that sponges represent the sister lineage to the rest of the animals, while other phylogenomic analyses support ctenophores, a phylum of carnivorous, gelatinous marine organisms, as the sister lineage...
October 9, 2017: Current Biology: CB
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