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https://www.readbyqxmd.com/read/28922030/rapid-detection-and-classification-of-salmonella-enterica-shedding-in-feedlot-cattle-utilizing-the-roka-bioscience-atlas-salmonella-detection-assay-for-the-analysis-of-rectoanal-mucosal-swabs
#1
W Evan Chaney, Getahun E Agga, Scott V Nguyen, Terrance M Arthur, Joseph M Bosilevac, Erin Dreyling, Anantharama Rishi, Dayna Brichta-Harhay
With an increasing focus on preharvest food safety, rapid methods are required for the detection and quantification of foodborne pathogens such as Salmonella enterica in beef cattle. We validated the Atlas Salmonella Detection Assay (SEN), a nucleic acid amplification technology that targets Salmonella rRNA, for the qualitative detection of S. enterica with sample enrichment using immunomagnetic separation as a reference test, and we further evaluated its accuracy to predict pathogen load using SEN signal-to-cutoff (SCO) values from unenriched samples to classify animals as high or nonhigh shedders...
September 18, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28903758/factors-associated-with-malaria-microscopy-diagnostic-performance-following-a-pilot-quality-assurance-programme-in-health-facilities-in-malaria-low-transmission-areas-of-kenya-2014
#2
Fredrick Odhiambo, Ann M Buff, Collins Moranga, Caroline M Moseti, Jesca Okwara Wesongah, Sara A Lowther, Wences Arvelo, Tura Galgalo, Thomas O Achia, Zeinab G Roka, Waqo Boru, Lily Chepkurui, Bernhards Ogutu, Elizabeth Wanja
BACKGROUND: Malaria accounts for ~21% of outpatient visits annually in Kenya; prompt and accurate malaria diagnosis is critical to ensure proper treatment. In 2013, formal malaria microscopy refresher training for microscopists and a pilot quality-assurance (QA) programme for malaria diagnostics were independently implemented to improve malaria microscopy diagnosis in malaria low-transmission areas of Kenya. A study was conducted to identify factors associated with malaria microscopy performance in the same areas...
September 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28864036/aerobic-training-effect-on-arterial-stiffness-in-metabolic-syndrome
#3
Ieva Slivovskaja, Ligita Ryliskyte, Pranas Serpytis, Rokas Navickas, Jolita Badarienė, Jelena Celutkiene, Roma Puronaite, Kristina Ryliskiene, Alma Cypiene, Egidija Rinkuniene, Vaida Sileikiene, Birute Petrauskiene, Alvydas Juocevicius, Aleksandras Laucevicius
BACKGROUND: Metabolic syndrome, physical inactivity and central obesity contribute to early vascular aging, which leads to increased risk of cardiovascular disease. The study aimed to assess the effect of heart rate (HR) targeted aerobic exercise training on the indices of early vascular aging, in particular, arterial stiffness, and on anthropometric and clinical profile of metabolic syndrome subjects. METHODS: 126 metabolic syndrome subjects were randomly selected...
August 29, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28864013/the-transformative-potential-of-an-integrative-approach-to-pregnancy
#4
Haley R Eidem, Kriston L McGary, John A Capra, Patrick Abbot, Antonis Rokas
BACKGROUND: Complex traits typically involve diverse biological pathways and are shaped by numerous genetic and environmental factors. Pregnancy-associated traits and pathologies are further complicated by extensive communication across multiple tissues in two individuals, interactions between two genomes-maternal and fetal-that obscure causal variants and lead to genetic conflict, and rapid evolution of pregnancy-associated traits across mammals and in the human lineage. Given the multi-faceted complexity of human pregnancy, integrative approaches that synthesize diverse data types and analyses harbor tremendous promise to identify the genetic architecture and environmental influences underlying pregnancy-associated traits and pathologies...
September 2017: Placenta
https://www.readbyqxmd.com/read/28859699/method-modification-for-the-atlas-listeria-environmental-le-detection-assay-using-foodchek-actero-listeria-enrichment-media-and-half-fraser-media-for-the-detection-of-listeria-spp-from-environmental-surfaces
#5
Brett Maroni, Tucker Lopez, Cambria Neal, Sarah Verver, Celina Puente, Jannelle Lauffer, Joseph Garcia, Bettina Groschel, Erin Dreyling, W Evan Chaney, Ben Bastin, Patrick Bird, M Joseph Benzinger, James Agin, David Goins, Upasana Hariram, Yi Chen, Elliot Ryser, Michael Brodsky
Two candidate method modifications for the Atlas Listeria Environmental LE Detection Assay were compared with the U.S. Department of Agriculture (USDA)-Food Safety and Inspection Service Microbiology Laboratory Guidebook 8.09 (MLG 8.09) method for detection of Listeria spp. on stainless steel, polyvinyl chloride (PVC), and sealed concrete surfaces. For LE candidate method 1, samples were enriched in FoodChek Actero Listeria Enrichment Media [ALEM; Performance Tested Method(SM) (PTM) 111201] at 35 ± 2°C for 18 to 24 h and evaluated for a range of analytical sample volumes...
August 31, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28829287/correction-%C3%A2-heredity-the-gene-family-that-cheats-mendel
#6
J Dylan Shropshire, Antonis Rokas
No abstract text is available yet for this article.
August 22, 2017: ELife
https://www.readbyqxmd.com/read/28815214/chlamydomonas-reinhardtii-lfo1-is-an-isdg-family-heme-oxygenase
#7
Lisa J Lojek, Allison J Farrand, Jennifer H Wisecaver, Crysten E Blaby-Haas, Brian W Michel, Sabeeha S Merchant, Antonis Rokas, Eric P Skaar
Heme is essential for respiration across all domains of life. However, heme accumulation can lead to toxicity if cells are unable to either degrade or export heme or its toxic by-products. Under aerobic conditions, heme degradation is performed by heme oxygenases, enzymes which utilize oxygen to cleave the tetrapyrrole ring of heme. The HO-1 family of heme oxygenases has been identified in both bacterial and eukaryotic cells, whereas the IsdG family has thus far been described only in bacteria. We identified a hypothetical protein in the eukaryotic green alga Chlamydomonas reinhardtii, which encodes a protein containing an antibiotic biosynthesis monooxygenase (ABM) domain consistent with those associated with IsdG family members...
July 2017: MSphere
https://www.readbyqxmd.com/read/28812701/contentious-relationships-in-phylogenomic-studies-can-be-driven-by-a-handful-of-genes
#8
Xing-Xing Shen, Chris Todd Hittinger, Antonis Rokas
Phylogenomic studies have resolved countless branches of the tree of life, but remain strongly contradictory on certain, contentious relationships. Here, we use a maximum likelihood framework to quantify the distribution of phylogenetic signal among genes and sites for 17 contentious branches and 6 well-established control branches in plant, animal and fungal phylogenomic data matrices. We find that resolution in some of these 17 branches rests on a single gene or a few sites, and that removal of a single gene in concatenation analyses or a single site from every gene in coalescence-based analyses diminishes support and can alter the inferred topology...
April 10, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28800687/the-profound-effect-of-harmful-cyanobacterial-blooms-from-food-web-and-management-perspectives
#9
Sigitas Šulčius, Danguolė Montvydienė, Hanna Mazur-Marzec, Jūratė Kasperovičienė, Rokas Rulevičius, Živilė Cibulskaitė
Sustainable and effective water management plans must have a reliable risk assessment strategies for harmful cyanobacterial blooms (HABs) that would enable timely decisions to be made, thus avoiding the trespassing of ecological thresholds, leading to the collapse of ecosystem structure and function. Such strategies are usually based on cyanobacterial biomass and/or on the monitoring of known toxins, which may, however, in many cases, under- or over-represent the actual toxicity of the HAB. Therefore, in this study, by the application of growth-inhibition assays using different bacteria, algae, zooplankton and fish species, we assessed the toxicological potential of two cyanobacterial blooms that differed in total cyanobacterial biomass, species composition and cyanopeptide profiles...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28782246/the-surgical-anatomy-of-the-vascularized-lateral-thoracic-artery-lymph-node-flap-a-cadaver-study
#10
Ines E Tinhofer, Stefan Meng, Johannes Steinbacher, Julia Roka-Palkovits, Eva Györi, Lukas F Reissig, Ming-Huei Cheng, Wolfgang J Weninger, Chieh-Han J Tzou
BACKGROUND: One promising surgical treatment of lymphedema is the VLNT. Lymph nodes can be harvested from different locations; inguinal, axillary, and supraclavicular ones are used most often. The aim of our study was to assess the surgical anatomy of the lateral thoracic artery lymph node flap. MATERIALS AND METHODS: In total, 16 lymph node flaps from nine cadavers were dissected. Flap markings were made between the anterior and posterior axillary line in dimensions of 10 × 5 cm...
August 7, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28720755/functional-variants-of-the-melanocortin-4-receptor-associated-with-the-odontoceti-and-mysticeti-suborders-of-cetaceans
#11
Liyuan Zhao, Xiaofan Zhou, Antonis Rokas, Roger D Cone
Cetaceans, a group of mammals adapted to the aquatic environment that descended from terrestrial artiodactyls, exhibit tremendous interspecific differences in a number of phenotypes, including feeding behavior, such as filter feeding in the Mysticeti vs prey-hunting Odontoceti, and size, with the smallest cetacean, the vaquita, at 1.4 meters and the largest, the blue whale, reaching 33 meters. The Melanocortin-4 receptor (MC4R) regulates food intake, energy balance, and somatic growth in both mammals and teleosts...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715077/age-and-gender-related-peculiarities-of-patients-with-delirium-in-the-cardiac-intensive-care-unit
#12
Pranas Serpytis, Petras Navickas, Alvydas Navickas, Rokas Serpytis, Giedrius Navickas, Sigita Glaveckaite
BACKGROUND: The overall evidence base regarding delirium has been growing steadily over the past few decades. There has been considerable analysis of delirium concerning, for example, mechanically ventilated patients, patients in the general intensive care unit (ICU) setting, and patients with exclusively postoperative delirium. Nevertheless, there are few studies regarding delirium in a cardiovascular ICU (ICCU) setting and especially scarce literature about the particular features of delirium relating to patient age and gender...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714722/pilot-testing-the-daily-activities-list-for-inmates-dali-item-evaluation-and-content-validity
#13
Philip R Magaletta, Rokas Perskaudas, Christina J Connors, Marc W Patry, Jarrod Reisweber, Alix McLearen
Scheduling enjoyable daily activities is a Cognitive Behavioral Therapy intervention used in the treatment of depression and substance abuse disorders that are prevalent disorders among inmates. To effectively use this intervention with inmates, an activities list with items ecologically sensitive to the correctional setting needs to be created. The purpose of this study was to develop and evaluate items; thus, establishing a content valid Daily Activities List for Inmates (DALI). Fifteen corrections professionals representing a wide range of disciplines and managerial backgrounds served as subject matter experts (SMEs)...
July 17, 2017: Psychological Services
https://www.readbyqxmd.com/read/28691723/effect-of-ethanol-on-the-visual-evoked-potential-in-rat-dynamics-of-on-and-off-responses
#14
Redas Dulinskas, Rokas Buisas, Valentina Vengeliene, Osvaldas Ruksenas
The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute administration of ethanol...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28677124/myba-a-transcription-factor-involved-in-conidiation-and-conidial-viability-of-the-human-pathogen-aspergillus-fumigatus
#15
Isabel Valsecchi, Özlem Sarikaya-Bayram, Joanne Wong Sak Hoi, Laetitia Muszkieta, John Gibbons, Marie-Christine Prevost, Adeline Mallet, Jacomina Krijnse-Locker, Oumaima Ibrahim-Granet, Isabelle Mouyna, Paul Carr, Michael Bromley, Vishukumar Aimanianda, Jae-Hyuk Yu, Antonis Rokas, Gerhard H Braus, Cosmin Saveanu, Özgür Bayram, Jean Paul Latgé
Aspergillus fumigatus, a ubiquitous human fungal pathogen, produces asexual spores (conidia), which are the main mode of propagation, survival and infection of this human pathogen. In this study, we present the molecular characterization of a novel regulator of conidiogenesis and conidial survival called MybA because the predicted protein contains a Myb DNA binding motif. Cellular localization of the MybA::Gfp fusion and immunoprecipitation of the MybA::Gfp or MybA::3xHa protein showed that MybA is localized to the nucleus...
July 5, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28666417/identifying-differential-mir-and-gene-consensus-patterns-in-peripheral-blood-of-patients-with-cardiovascular-diseases-from-literature-data
#16
Agnė Šatrauskienė, Rokas Navickas, Aleksandras Laucevičius, Heinrich J Huber
BACKGROUND: Numerous recent studies suggest the potential of circulating MicroRNAs (miRs) in peripheral blood samples as diagnostic or prognostic markers for coronary artery disease (CAD), acute coronary syndrome (ACS) and heart failure (HF). However, literature often remains inconclusive regarding as to which markers are most indicative for which of the above diseases. This shortcoming is mainly due to the lack of a systematic analyses and absence of information on the functional pathophysiological role of these miRs and their target genes...
June 30, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28658268/weta-bridges-cellular-and-chemical-development-in-aspergillus-flavus
#17
Ming-Yueh Wu, Matthew E Mead, Sun-Chang Kim, Antonis Rokas, Jae-Hyuk Yu
Bridging cellular reproduction and survival is essential for all life forms. Aspergillus fungi primarily reproduce by forming asexual spores called conidia, whose formation and maturation is governed by the central genetic regulatory circuit BrlA→AbaA→WetA. Here, we report that WetA is a multi-functional regulator that couples spore differentiation and survival, and governs proper chemical development in Aspergillus flavus. The deletion of wetA results in the formation of conidia with defective cell walls and no intra-cellular trehalose, leading to reduced stress tolerance, a rapid loss of viability, and disintegration of spores...
2017: PloS One
https://www.readbyqxmd.com/read/28631611/the-gene-family-that-cheats-mendel
#18
J Dylan Shropshire, Antonis Rokas
Some alleles of the wtf gene family can increase their chances of spreading by using poisons to kill other alleles, and antidotes to save themselves.
June 20, 2017: ELife
https://www.readbyqxmd.com/read/28523911/cup-shaped-nanoantenna-arrays-for-zeptoliter-volume-biochemistry-and-plasmonic-sensing-in-the-visible-wavelength-range
#19
Rokas Drevinskas, Tomas Rakickas, Algirdas Selskis, Lorenzo Rosa, Ramu Nas Valiokas
Although three-dimensional shaping of metallic nanostructures is an important strategy for control and manipulation of localized surface plasmon resonance (LSPR), its implementation in high-throughput, on-chip fabrication of plasmonic devices remains challenging. Here, we demonstrate nanocontact-based large-area fabrication of a novel, LSPR-active Au architecture consisting of periodic arrays of reduced-symmetry nanoantennas having sub-50 nm, out-of-plane features. Namely, by combining nanosphere and molecular self-assembly processes, we have patterned evaporated polycrystalline Au films for chemical etching of nanocups with controlled aspect ratios (outer diameter d = 100 nm and void volumes = 18 or 39 zL)...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28498473/sulforaphane-sensitizes-human-cholangiocarcinoma-to-cisplatin-via-the-downregulation-of-anti-apoptotic-proteins
#20
Rokas Račkauskas, Dachen Zhou, Simonas Ūselis, Kęstutis Strupas, Ingrid Herr, Peter Schemmer
Cholangiocarcinoma (CCC) is an aggressive malignancy with poor therapeutic options and pronounced chemotherapy resistance. The bioactive broccoli substance, sulforaphane (SFN), is a promising new therapeutic option since it has been found to induce therapeutic effects in both experimental and epidemiological studies in various tumor entities. Thus, the present study was designed to assess the effect of SFN on cisplatin sensitivity in CCC. Human HuCCT-1 and TFK-1 cells, representing intrahepatic and extrahepatic CCC, respectively, were treated with cisplatin and SFN...
May 3, 2017: Oncology Reports
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