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https://www.readbyqxmd.com/read/28441729/the-influence-of-hydroxyapatite-nanoparticle-morphology-on-embryonic-development-in-a-zebrafish-exposure-model
#1
Shiuli Pujari-Palmer, Xi Lu, Marjam Karlsson Ott
Nanomaterials are used in many different industries such as cosmetics, food, clothing, and electronics. There is increasing concern that exposure to nanoparticles (NPs) during pregnancy can adversely affect fetal development. It is well known that the size, charge, and chemistry of a nanoparticle can modulate embryological development. The role that particle morphology plays on early development, however, is still widely unknown. The present study aims to investigate the effect of hydroxyapatite nanoparticle (HANP) morphology on embryological development in a zebrafish exposure model...
April 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28438110/temporal-progression-of-lesions-in-guinea-pigs-infected-with-lassa-virus
#2
T M Bell, C I Shaia, J J Bearss, M E Mattix, K A Koistinen, S P Honnold, X Zeng, C D Blancett, G C Donnelly, J D Shamblin, E R Wilkinson, K A Cashman
Lassa virus (LASV) infection causes an acute, multisystemic viral hemorrhagic fever that annually infects an estimated 100 000 to 300 000 persons in West Africa. This pathogenesis study evaluated the temporal progression of disease in guinea pigs following aerosol and subcutaneous inoculation of the Josiah strain of LASV as well as the usefulness of Strain 13 guinea pigs as an animal model for Lassa fever. After experimental infection, guinea pigs ( Cavia porcellus; n = 67) were serially sampled to evaluate the temporal progression of infection, gross and histologic lesions, and serum chemistry and hematologic changes...
May 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28434257/ratio-of-serum-levels-of-ages-to-soluble-rage-is-correlated-with-trimethylamine-n-oxide-in-non-diabetic-subjects
#3
Atsuko Tahara, Nobuhiro Tahara, Sho-Ichi Yamagishi, Akihiro Honda, Sachiyo Igata, Yoshikazu Nitta, Munehisa Bekki, Tomohisa Nakamura, Yoichi Sugiyama, Jiahui Sun, Masayoshi Takeuchi, Makiko Shimizu, Hiroshi Yamazaki, Kei Fukami, Yoshihiro Fukumoto
Trimethylamine (TMA), an intestinal microflora-dependent metabolite formed from phosphatidylcholine- and L-carnitine-rich food, such as red meat, is further converted to trimethylamine-N-oxide (TMAO), which could play a role in cardiometabolic disease. Red meat-derived products are one of the major environmental sources of advanced glycation end products (AGEs) that may also contribute to the pathogenesis of cardiometabolic disorders through the interaction with receptor for AGEs (RAGE). However, the relationship among AGEs, soluble form of RAGE (sRAGE) and TMAO in humans remains unclear...
April 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28430700/prescriber-compliance-with-liver-monitoring-guidelines-for-pazopanib-in-the-postapproval-setting-results-from-a-distributed-research-network
#4
Sumitra Shantakumar, Beth L Nordstrom, Susan A Hall, Luc Djousse, Myrthe P P van Herk-Sukel, Kathy H Fraeman, David R Gagnon, Karen Chagin, Jeanenne J Nelson
OBJECTIVES: Pazopanib received US Food and Drug Administration approval in 2009 for advanced renal cell carcinoma. During clinical development, liver chemistry abnormalities and adverse hepatic events were observed, leading to a boxed warning for hepatotoxicity and detailed label prescriber guidelines for liver monitoring. As part of postapproval regulatory commitments, a cohort study was conducted to assess prescriber compliance with liver monitoring guidelines. METHODS: Over a 4-year period, a distributed network approach was used across 3 databases: US Veterans Affairs Healthcare System, a US outpatient oncology community practice database, and the Dutch PHARMO Database Network...
April 20, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28428020/repeated-sub-chronic-oral-toxicity-study-of-xylooligosaccharides-xos-in-dogs
#5
Yonglin Gao, Yunzhi Wang, Yanshen Li, Rui Han, Chunmei Li, Lin Xiao, Susan Cho, Yukui Ma, Chao Fang, Albert W Lee
In this study, Beagle dogs were administered xylooligosaccharide (XOS, CAS # 87099-0) at doses of 0, 1250, 2500, and 5000 mg/kg/day by oral gavage for 26 weeks. A 4-week recovery period was added to observe delayed or reversible toxicity. Measurements included body weight, food consumption, clinical observations, temperature, electrocardiogram (ECG), urinalysis, blood chemistry, hematology, organ weight, gross necropsy, and histopathological examination. Except for transient diarrhea or vomiting, no treatment-related adverse effects were noted...
April 17, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28421385/in-vitro-and-in-vivo-anti-tumor-effects-of-selected-platinum-iv-and-dinuclear-platinum-ii-complexes-against-lung-cancer-cells
#6
Milos Arsenijevic, Marija Milovanovic, Snezana Jovanovic, Natalija Arsenijevic, Bojana Simovic Markovic, Marina Gazdic, Vladislav Volarevic
In the present study, cytotoxic effects of cisplatin, the most usually used chemotherapeutic agent, were compared with new designed platinum(IV) ([PtCl4(en)] (en = ethylenediamine) and [PtCl4(dach)]) (dach = (±)-trans-1,2-diaminocyclohexane) and platinum(II) complexes ([{trans-Pt(NH3)2Cl}2(μ-pyrazine)](ClO4)2 (Pt1), [{trans-Pt(NH3)2Cl}2(μ-4,4'-bipyridyl)](ClO4)2DMF(Pt2),[{trans-Pt(NH3)2Cl}2(μ-1,2-bis(4pyridyl)ethane)](ClO4)2 (Pt3)), in vitro and in vivo against human and murine lung cancer cells, to determine anti-tumor potential of newly synthesized platinum-based drugs in the therapy of lung cancer...
April 18, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28419173/sponge-symbioses-between-xestospongia-deweerdtae-and-plakortis-spp-are-not-motivated-by-shared-chemical-defense-against-predators
#7
Micah Jaarsma Marty, Jan Vicente, Benjamin L Oyler, Allen Place, Russell T Hill
The recently described epizoic sponge-sponge symbioses between Xestospongia deweerdtae and two species of Plakortis present an unusual series of sponge interactions. Sponges from the genus Plakortis are fierce allelopathic competitors, rich in cytotoxic secondary metabolites, and yet X. deweerdtae flourishes as an epizoic encrustation on Plakortis deweerdtaephila and Plakortis symbiotica. Our objective in this study was to evaluate the hypothesis that X. deweerdtae grows epizoic to these two species of Plakortis due to a shared chemical defense against predators...
2017: PloS One
https://www.readbyqxmd.com/read/28417091/biological-activities-of-curcuminoids-other-biomolecules-from-turmeric-and-their-derivatives-a-review
#8
REVIEW
Augustine Amalraj, Anitha Pius, Sreerag Gopi, Sreeraj Gopi
In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28414232/application-of-deep-eutectic-solvents-des-for-phenolic-compounds-extraction-overview-challenges-and-opportunities
#9
Mariana Ruesgas-Ramon, Maria Cruz Figueroa-Espinoza, Erwann Durand
The green chemistry era has pushed the scientific community to investigate and implement new solvents in the phenolic compounds (PC) extraction, as alternative to the organic solvents which are toxic and may be dangerous. Recently, Deep Eutectic Solvents (DES) have been applied as extraction solvents of PC. They have the advantages to be biodegradable, easy to handle with very low toxicity. Nevertheless, the extraction process is affected by several factors: affinity between DES and the target compounds, the water content, the molar ratio between DES' starting molecules, the liquid:solid ratio between the DES and sample, and the conditions and extraction method...
April 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28405231/secondary-metabolome-and-its-defensive-role-in-the-aeolidoidean-phyllodesmium-longicirrum-gastropoda-heterobranchia-nudibranchia
#10
Alexander Bogdanov, Cora Hertzer, Stefan Kehraus, Samuel Nietzer, Sven Rohde, Peter J Schupp, Heike Wägele, Gabriele M König
Phyllodesmium longicirrum is the largest aeolidoidean species known to date, and extremely rich in terpenoid chemistry. Herein we report the isolation of a total of 19 secondary metabolites from a single specimen of this species, i.e., steroids 1-4, cembranoid diterpenes 5-13, complex biscembranoids 14 and 15, and the chatancin-type diterpenes 16-19. These compounds resemble those from soft corals of the genus Sarcophyton, of which to date, however, only S. trocheliophorum is described as a food source for P...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28403572/development-and-application-of-a-probabilistic-risk-benefit-assessment-model-for-infant-feeding-integrating-microbiological-nutritional-and-chemical-components
#11
Géraldine Boué, Enda Cummins, Sandrine Guillou, Jean-Philippe Antignac, Bruno Le Bizec, Jeanne-Marie Membré
A probabilistic and interdisciplinary risk-benefit assessment (RBA) model integrating microbiological, nutritional, and chemical components was developed for infant milk, with the objective of predicting the health impact of different scenarios of consumption. Infant feeding is a particular concern of interest in RBA as breast milk and powder infant formula have both been associated with risks and benefits related to chemicals, bacteria, and nutrients, hence the model considers these three facets. Cronobacter sakazakii, dioxin-like polychlorinated biphenyls (dl-PCB), and docosahexaenoic acid (DHA) were three risk/benefit factors selected as key issues in microbiology, chemistry, and nutrition, respectively...
April 12, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28401315/improving-the-tool-box-for-robust-industrial-enzymes
#12
REVIEW
J A Littlechild
The speed of sequencing of microbial genomes and metagenomes is providing an ever increasing resource for the identification of new robust biocatalysts with industrial applications for many different aspects of industrial biotechnology. Using 'natures catalysts' provides a sustainable approach to chemical synthesis of fine chemicals, general chemicals such as surfactants and new consumer-based materials such as biodegradable plastics. This provides a sustainable and 'green chemistry' route to chemical synthesis which generates no toxic waste and is environmentally friendly...
April 11, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28400976/iss-n1-makes-the-first-fda-approved-drug-for-spinal-muscular-atrophy
#13
Eric W Ottesen
Spinal muscular atrophy (SMA) is one of the leading genetic diseases of children and infants. SMA is caused by deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, cannot compensate for the loss of SMN1 due to predominant skipping of exon 7. While various regulatory elements that modulate SMN2 exon 7 splicing have been proposed, intronic splicing silencer N1 (ISS-N1) has emerged as the most promising target thus far for antisense oligonucleotide-mediated splicing correction in SMA...
January 2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28400834/comparison-of-commonly-used-icr-stocks-and-the-characterization-of-korl-icr
#14
Hye-Jun Shin, Young Min Cho, Hee Jung Shin, Hae Deun Kim, Kyung Min Choi, Mi Gyeong Kim, Hyoung Doo Shin, Myeon-Woo Chung
Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infection and pharmacology research. The National Institute of Food and Drug Safety Evaluation (NIFDS; former the Korea National Institute of Health) have bred ICR mice for more than 50 years. We investigated to provide users with information and promote accountability to the Korl:ICR. To secure the indigenous data, biological characteristics of Korl:ICR were identified by comparing with other ICR stocks...
March 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28392987/profiling-transcriptomes-of-human-sh-sy5y-neuroblastoma-cells-exposed-to-maleic-acid
#15
Chia-Chi Wang, Yin-Chi Lin, Yin-Hua Cheng, Chun-Wei Tung
BACKGROUND: Maleic acid is a multi-functional chemical widely used in the field of industrial chemistry for producing food additives and food contact materials. As maleic acid may contaminate food by the release from food packages or intentional addition, it raises the concern about the effects of excessive dietary exposure to maleic acid on human health. However, the influence of maleic acid on human health has not been thoroughly studied. In silico toxicogenomics approaches have found the association between maleic acid and nervous system disease in human...
2017: PeerJ
https://www.readbyqxmd.com/read/28391863/evaluation-of-new-natural-deep-eutectic-solvents-for-the-extraction-of-isoflavones-from-soy-products
#16
Sylwia Bajkacz, Jakub Adamek
Natural deep eutectic solvents (NADESs) are considered to be new, safe solvents in green chemistry that can be widely used in many chemical processes such as extraction or synthesis. In this study, a simple extraction method based on NADES was used for the isolation of isoflavones (daidzin, genistin, genistein, daidzein) from soy products. Seventeen different NADES systems each including two or three components were tested. Multivariate data analysis revealed that NADES based on a 30% solution of choline chloride: citric acid (molar ratio of 1:1) are the most effective systems for the extraction of isoflavones from soy products...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28391688/total-as-and-as-speciation-in-italian-rice-as-related-to-producing-areas-and-paddy-soils-properties
#17
Daniele Tenni, Maria Martin, Elisabetta Barberis, Gian Maria Beone, Eleonora Miniotti, Marcella Sodano, Elena Zanzo, Maria Chiara Fontanella, Marco Romani
Rice and rice-based foodstuffs are important pathways for inorganic As dietary intake. This work shows a detailed picture of As content and speciation in Italian rice, which contributes to more than one half of European production, and addresses the role of soil chemistry and agronomic management on As concentration in rice grain, in view of ameliorative strategies. The mean total As content in Italian white rice was 155±65 µg kg-1 with significant differences among producing areas, while the mean inorganic As was 102±26 µg kg-1, largely below the E...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28389326/lipid-soluble-green-tea-extract-genotoxicity-and-subchronic-toxicity-studies
#18
Zheng Liu, Dongying Liu, Jianguo Cheng, Song Mei, Ying Fu, Weiqi Lai, Yin Wang, Yihong Xu, Trung D Vo, Barry S Lynch
To assess the potential safety of lipid soluble green tea extract, also referred to as lipid soluble tea polyphenols (LSTP), a series of genotoxicity tests were conducted, including an Ames, in vivo mouse micronucleus, and in vivo mouse sperm abnormality test. The toxicity of LSTP was evaluated in 90- and 30-day feeding studies. LSTP did not show mutagenic activity in the Ames test and no genotoxic potential in the in vivo assays at doses up to 10 g/kg body weight (bw). In the 90-day feeding study, LSTP was given in the diet at levels providing 0, 0...
April 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28375635/real-time-observation-of-hydrogen-peroxide-transport-through-the-oil-phase-in-a-w-o-w-double-emulsion-with-chemiluminescence-emission
#19
Hiroshi Kouno, Yosuke Iwai, Yoshiaki Uchida, Yuichiro Hirota, Norikazu Nishiyama
The evaluation of the transport rates of hydrophilic substances is important in agricultural and pharmaceutical chemistry and in the cosmetics and food-processing industries. Although there are some estimation methods focusing on the diffusion of the substances through the oil phase of the W/O/W core-shell double emulsions (oil microcapsules), all of them take several hours or days. This long-time measurement has a risk of rupture of the oil microcapsules, which causes significant errors. If it were possible to measure the transport rate of substances in the oil phase of the oil microcapsules in real time, the risk of rupture could be reduced...
April 4, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28372166/octadecylimidazolium-ionic-liquid-modified-magnetic-materials-preparation-adsorption-evaluation-and-their-excellent-application-for-honey-and-cinnamon
#20
Houmei Liu, Zhan Li, Makoto Takafuji, Hirotaka Ihara, Hongdeng Qiu
A novel and versatile adsorbent based on 1-octadecylimidazolium ionic liquid modified magnetic nanoparticles (Fe3O4@SiO2@ImC18) possessing of both magnetic property and excellent adsorption ability was successfully synthesized. Twelve compounds from four kinds of substances (alkylbenzenes, PAHs, flavonoids and organic acids) were chosen as probe molecules to evaluate adsorption properties of the new adsorbent. A series of adsorption experiments were conducted and results indicated both synergism and competition effects were existed and multiple interactions took place during adsorption process...
August 15, 2017: Food Chemistry
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