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https://www.readbyqxmd.com/read/29343970/a-retrospective-examination-of-the-us-food-and-drug-administration-s-clinical-pharmacology-reviews-of-oncology-biologics-for-potential-use-of-therapeutic-drug-monitoring
#1
Brett Fleisher, Sihem Ait-Oudhia
Background: Biologics have gained traction for use in oncology, but have demonstrate clinical variability for efficacy and safety. Therapeutic drug monitoring (TDM) can benefit patients' outcomes from a biologic therapy when the latter has a defined therapeutic window. A clinically relevant therapeutic window may exist for biologics with established exposure-response (E-R) relationships for efficacy and/or safety and a documented maximum tolerated dose (MTD). Additionally, the inter-individual variability (IIV) on the clearance (CL) parameter could determine risks for patients falling outside the proposed therapeutic window...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29339554/synthetic-biology-strategies-for-improving-microbial-synthesis-of-green-biopolymers
#2
Lisa A Anderson, M Ahsanul Islam, Kristala L J Prather
Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select "green" biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed...
January 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29337656/a-review-of-methodology-for-the-analysis-of-pyrethrin-and-pyrethroid-residues-in-food-of-animal-origin
#3
S Tuck, A Furey, S R H Crooks, M Danaher
Pyrethrin and pyrethroid pesticides are commonly used in crop protection and animal health, to control pests. As a result, they can potentially transfer into food if good agricultural practice is not followed or even due to accidental contamination. The analysis of these compounds has been widely reported in crops and the environment. However, the analysis of pyrethrin and pyrethroids has not been reported frequently in foods of animal origin, particularly animal tissues. The focus of this review is to report on pyrethrin and pyrethroid analysis including key aspects such as chemistry, choice of target matrix, sample preparation, chemical analysis, legislation and method validation...
January 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29335210/privileged-scaffolds-as-mao-inhibitors-retrospect-and-prospects
#4
REVIEW
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
This review aims to be a comprehensive, authoritative, critical, and readable review of general interest to the medicinal chemistry community because it focuses on the pharmacological, chemical, structural and computational aspects of diverse chemical categories as monoamine oxidase inhibitors (MAOIs). Monoamine oxidases (MAOs), namely MAO-A and MAO-B represent an enormously valuable class of neuronal enzymes embodying neurobiological origin and functions, serving as potential therapeutic target in neuronal pharmacotherapy, and hence we have coined the term "Neurozymes" which is being introduced for the first time ever...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29332786/recent-advances-and-developments-on-integrating-nanotechnology-with-chemiluminescence-assays
#5
REVIEW
Ashish Tiwari, S J Dhoble
Chemiluminescence (CL) techniques are extensively utilized for detection of analytes due to their high sensitivity, rapidity and selectivity. With the advent of nanotechnology and incorporation of the nanoparticles in the CL system has revolutionized the assays due to their unique optical and mechanical properties. Several CL-based reactions have been developed where these nanoparticle based CL sensors have evolved as excellent prospects for sensing in various analytical applications. This review article addresses the nanoparticles based CL detection system that are recently developed, the mechanisms has been summarized and the role of luminophors have been discussed...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29324394/effects-of-ocean-acidification-on-copepods
#6
REVIEW
Minghua Wang, Chang-Bum Jeong, Young Hwan Lee, Jae-Seong Lee
Ocean acidification (OA) leads to significant changes in seawater carbon chemistry, broadly affects marine organisms, and considered as a global threat to the fitness of marine ecosystems. Due to the crucial role of copepods in marine food webs of transferring energy from primary producers to higher trophic levels, numerous studies have been conducted to examine the impacts of OA on biological traits of copepods such as growth and reproduction. Under OA stress, the copepods demonstrated species-specific and stage-dependent responses...
January 5, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29319937/medical-devices-clinical-chemistry-and-clinical-toxicology-devices-classification-of-the-reagents-for-molecular-diagnostic-instrument-test-systems-final-order
#7
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the reagents for molecular diagnostic instrument test systems into class I (general controls). We are taking this action because we have determined that classifying the device into class I (general controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
December 27, 2017: Federal Register
https://www.readbyqxmd.com/read/29315702/strategies-to-target-the-hedgehog-signaling-pathway-for-cancer-therapy
#8
REVIEW
Minhang Xin, Xinyue Ji, Ladie Kimberly De La Cruz, Suresh Thareja, Binghe Wang
Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation of the Hh signaling pathway through sporadic mutations or other mechanisms is explicitly associated with cancer development and progression in various solid malignancies. Therefore, targeted inhibition of the Hh signaling pathway has emerged as an attractive and validated therapeutic strategy for the treatment of a wide range of cancers. Vismodegib, a first-in-class Hh signaling pathway inhibitor was approved by the US Food and Drug Administration in 2012, and sonidegib, another potent Hh pathway inhibitor, received FDA's approval in 2015 as a new treatment of locally advanced or metastatic basal cell carcinoma...
January 5, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29314284/the-mercury-problem-in-artisanal-and-small-scale-gold-mining
#9
Louisa J Esdaile, Justin M Chalker
Mercury-dependent artisanal and small-scale gold mining (ASGM) is the largest source of mercury pollution on Earth. In this practice, elemental mercury is used to extract gold from ore as an amalgam. The amalgam is typically isolated by hand and then heated-often with a torch or over a stove-to distill the mercury and isolate the gold. Mercury emissions from tailings and vaporised mercury exceed 1000 tonnes each year from ASGM. The health effects on the miners are dire, with inhaled mercury leading to neurological damage and other health issues...
January 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29313428/biosynthesis-of-silver-nanoparticles-using-novel-bacillus-sp-sbt8
#10
Tuğçe Yurtluk, Fikriye Alev Akçay, Ayşe Avcı
Biosynthesis of silver nanoparticles (AgNPs) using microorganisms is an important application of nano-biotechnology and green chemistry because of interest by pharmaceutical and food manufacturers. In this study, biosynthesis of AgNPs by a novel Bacillus strain isolated from a soil sample from Sakarya district in Turkey was investigated. Biosynthesis was performed using cell-free supernatant of the bacterium following 24 h growth. Effects of varying AgNO3 concentration (1-10 mM), pH (5-10), and temperature (30-40°C) on the synthesis of AgNPs were determined...
January 9, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29298062/current-status-and-future-perspectives-in-flavor-research-highlights-of-the-11th-wartburg-symposium-on-flavor-chemistry-biology
#11
Thomas Hofmann, Dietmar Krautwurst, Peter Schieberle
The 11th Wartburg Symposium on Flavor Chemistry & Biology, held at the hotel "Auf der Wartburg" in Eisenach, Germany, from June 21 to 24 in 2016, offered a venue for global exchange and knowledge calibration of cutting-edge research in chemistry and biology of odor and taste. The focus areas were (1) Functional Flavor Genomics and Biotechnology, (2) Flavor Generation and Precursors, (3) New Approaches and Precursors, (4) New Approaches and Technologies, (5) New Molecules and Structure/Activity Relationships, (6) Food-Borne Bioactives and Chemosensory Health Prevention, and (7) Chemosensory Reception, Processing, and Perception...
January 3, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29295497/saffron-an-old-medicinal-plant-and-a-potential-novel-functional-food
#12
REVIEW
María José Bagur, Gonzalo Luis Alonso Salinas, Antonia M Jiménez-Monreal, Soukaina Chaouqi, Silvia Llorens, Magdalena Martínez-Tomé, Gonzalo L Alonso
The spice saffron is made from the dried stigmas of the plant Crocus sativus L. The main use of saffron is in cooking, due to its ability to impart colour, flavour and aroma to foods and beverages. However, from time immemorial it has also been considered a medicinal plant because it possesses therapeutic properties, as illustrated in paintings found on the island of Santorini, dated 1627 BC. It is included in Catalogues of Medicinal Plants and in the European Pharmacopoeias, being part of a great number of compounded formulas from the 16th to the 20th centuries...
December 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29289816/electrochemical-sensor-and-biosensor-platforms-based-on-advanced-nanomaterials-for-biological-and-biomedical-applications
#13
REVIEW
Govindhan Maduraiveeran, Manickam Sasidharan, Vellaichamy Ganesan
Introduction of novel functional nanomaterials and analytical technologies signify a foremost possibility for the advance of electrochemical sensor and biosensor platforms/devices for a broad series of applications including biological, biomedical, biotechnological, clinical and medical diagnostics, environmental and health monitoring, and food industries. The design of sensitive and selective electrochemical biological sensor platforms are accomplished conceivably by offering new surface modifications, microfabrication techniques, and diverse nanomaterials with unique properties for in vivo and in vitro medical analysis via relating a sensibly planned electrode/solution interface...
December 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29281279/response-to-comment-by-calderon-de-la-barca-and-sigala-robles-on-microbial-transglutaminase-used-in-bread-preparation-at-standard-bakery-concentrations-does-not-increase-immunodetectable-amounts-of-deamidated-gliadin
#14
Andreas Heil, Keiichi Yokoyama, Yoshiyuki Kumazawa, Martin Hils
To our publication "Microbial Transglutaminase Used in Bread Preparation at Standard Bakery Concentrations Does Not Increase Immunodetectable Amounts of Deamidated Gliadin" in Journal of Agricultural and Food Chemistry 2017 Aug 16;65(32):6982-6990 we received a comment by Calderon de la Barca an Sigala-Robles. Essentially the authors question the sense of analyzing MTG-treated bread in relation to celiac disease (because celiac patients do not eat bread) and also the technique of Western blotting we applied...
December 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29281271/comment-on-microbial-transglutaminase-used-in-bread-preparation-at-standard-bakery-concentrations-does-not-increase-immunodetectable-amounts-of-deamidated-gliadin
#15
Ana María Calderón De La Barca, Rodrigo Sigala-Robles
Concerns about the article by Heil, A.; Ohsam, J.; van Genugten, B.; Diez, O.; Yokoyama, K.; Kumazawa, Y.; Pasternack, R.; Hils, M. Microbial transglutaminase used in bread preparation at standard bakery concentrations does not increase immunodetectable amounts of deamidated gliadin. J Agric Food Chemistry. 2017, 65, 6982-6990.
December 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29277225/the-quantification-of-free-amadori-compounds-and-amino-acids-allows-to-model-the-bound-maillard-reaction-products-formation-in-soybean-products
#16
Antonio Dario Troise, Markus Wiltafsky, Vincenzo Fogliano, Paola Vitaglione
The quantification of protein bound Maillard reaction products (MRPs) is still a challenge in food chemistry. Protein hydrolysis is the bottleneck step: it is time consuming and the protein degradation is not always complete. In this study, the quantitation of free amino acids and Amadori products (APs) was compared to the percentage of blocked lysine by using chemometric tools. Eighty thermally treated soybean samples were analyzed by mass spectrometry to measure the concentration of free amino acids, free APs and the protein-bound markers of the Maillard reaction (furosine, Nε-(carboxymethyl)-l-lysine, Nε-(carboxyethyl)-l-lysine, total lysine)...
May 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29258368/lisdexamfetamine-chemistry-pharmacodynamics-pharmacokinetics-and-clinical-efficacy-safety-and-tolerability-in-the-treatment-of-binge-eating-disorder
#17
Kristen Ward, Leslie Citrome
The indications for lisdexamfetamine (LDX), a central nervous system stimulant, were recently expanded to include treatment of moderate to severe binge eating disorder (BED). Areas covered: This review aims to describe the chemistry and pharmacology of LDX, as well as the clinical trials investigating the efficacy and safety of this medication for the management of BED. Expert opinion: LDX is the first medication with United States Food and Drug Administration approval for the treatment of BED. It is an inactive prodrug of d-amphetamine that extends the half-life of d-amphetamine to allow for once daily dosing...
January 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29251504/cellulosic-nanomaterials-in-food-and-nutraceutical-applications-a-review
#18
Avik Khan, Yangbing Wen, Tanzina Huq, Yonghao Ni
Cellulosic nanomaterials (CNMs) are organic, green nanomaterials that are obtained from renewable sources and possess exceptional mechanical strength, and biocompatibility. The associated unique physical and chemical properties have made these nanomaterials an intriguing prospect for various applications including the food and nutraceutical industry. From the immobilization of various bioactive agents and enzymes, emulsion stabilization, direct food additives, to the development of intelligent packaging systems or pathogen or pH detectors, the potential food related applications for CNMs are endless...
December 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29248515/limonia-acidissima-l-leaf-mediated-synthesis-of-silver-and-zinc-oxide-nanoparticles-and-their-antibacterial-activities
#19
Bheemanagouda N Patil, T C Taranath
Green chemistry is a novel method for the synthesis of silver and zinc oxide nanoparticles. The present investigation focused on synthesis of biogenic silver and zinc oxide nanoparticles. They were assayed for their antibacterial activities against test bacterial species. The results revealed that the silver nanoparticles showed the maximum zone of inhibition 15.16, 15.5 and 13.33 mm at 400 μg/mL to S. aureus, S. typhi and P. aeruginosa respectively, when compared to the Erythromycin. While zinc oxide nanoparticles showed less activity in comparison to silver nanoparticles owing to the agglomeration of nanoparticles...
December 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29233680/new-fpg-probe-chemistry-for-direct-detection-of-recombinase-polymerase-amplification-on-lateral-flow-strips
#20
Michael L Powell, Frank R Bowler, Aurore J Martinez, Catherine J Greenwood, Niall Armes, Olaf Piepenburg
Rapid, cost-effective and sensitive detection of nucleic acids has the ability to improve upon current practices employed for pathogen detection in diagnosis of infectious disease and food testing. Furthermore, if assay complexity can be reduced, nucleic acid amplification tests could be deployed in resource-limited and home use scenarios. In this study, we developed a novel Fpg (Formamidopyrimidine DNA glycosylase) probe chemistry, which allows lateral flow detection of amplification in undiluted recombinase polymerase amplification (RPA) reactions...
December 9, 2017: Analytical Biochemistry
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