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https://www.readbyqxmd.com/read/28631236/use-of-ctx-i-and-pinp-as-bone-turnover-markers-national-bone-health-alliance-recommendations-to-standardize-sample-handling-and-patient-preparation-to-reduce-pre-analytical-variability
#1
P Szulc, K Naylor, N R Hoyle, R Eastell, E T Leary
N-terminal propeptide of type I procollagen and C-terminal telopeptide of type I collagen are the reference standards for bone turnover markers for monitoring osteoporosis treatment. We provide recommendations for standardized sample handling and encompassing aspects of preanalytical variability to improve the reproductibility of their measurements, their reliability, and clinical interpretation. The International Osteoporosis Foundation and International Federation of Clinical Chemistry bone turnover marker standards working group have identified N-terminal propeptide of type I procollagen (PINP) and C-terminal telopeptide of type I collagen (CTX-I) in the blood to be the international reference standards for bone turnover markers for the prediction of fracture risk and monitoring of osteoporosis treatment...
June 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28627385/advances-in-antibody-drug-conjugates-a-new-era-of-targeted-cancer-therapy
#2
REVIEW
Samaresh Sau, Hashem O Alsaab, Sushil Kumar Kashaw, Katyayani Tatiparti, Arun K Iyer
Antibody-drug conjugates (ADCs), a potent class of anticancer therapeutics, comprise a high-affinity antibody (Ab) and cytotoxic payload coupled via a suitable linker for selective tumor cell killing. In the initial phase of their development, two ADCs, Mylotarg(®), and Adcetris(®) were approved by the US Food and Drug Administration (FDA) for treating hematological cancer, but the real breakthrough came with the discovery of the breast cancer-targeting ADC, Kadcyla(®). With advances in bioengineering, linker chemistry, and potent cytotoxic payload, ADC technology has become a more powerful tool for targeted cancer therapy...
June 13, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28623656/quantum-dots-as-components-of-electrochemical-sensing-platforms-for-the-detection-of-environmental-and-food-pollutants-a-review
#3
María Pedrero, Susana Campuzano, José M Pingarrón
The determination of organic and inorganic environmental and food pollutants is a key matter of concern in analytical chemistry due to their effects as a serious threat to human health. Focusing on this issue, several methodologies involving the use of nanostructured electrochemical platforms have been recently reported in the literature. Among these methods, those employing the use of quantum dots (QDs) stand out because of features such as signal amplification, good reproducibility and selectivity, and the possibility for multiplexed detection, and because they preserve the outstanding characteristics of electrochemical methodologies with respect to simplicity, ease-of-use, and cost-effective instrumentation...
June 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28620771/oviposition-preference-for-young-plants-by-the-large-cabbage-butterfly-pieris-brassicae-does-not-strongly-correlate-with-caterpillar-performance
#4
Minghui Fei, Jeffrey A Harvey, Yi Yin, Rieta Gols
The effects of temporal variation in the quality of short-lived annual plants on oviposition preference and larval performance of insect herbivores has thus far received little attention. This study examines the effects of plant age on female oviposition preference and offspring performance in the large cabbage white butterfly Pieris brassicae. Adult female butterflies lay variable clusters of eggs on the underside of short-lived annual species in the family Brassicaceae, including the short-lived annuals Brassica nigra and Sinapis arvensis, which are important food plants for P...
June 15, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28609112/principles-of-electrospraying-a-new-approach-in-protection-of-bioactive-compounds-in-foods
#5
Ali Alehosseini, Behrouz Ghorani, Mahboobe Sarabi-Jamab, Nick Tucker
Electrospraying is a potential answer to the demands of nanoparticle fabrication such as scalability, reproducibility and effective encapsulation in food nanotechnology. Electrospraying (and the related process of electrospinning) both show promise as a novel delivery vehicle for supplementary food compounds since the process can be carried out from an aqueous solution, at room temperature and without coagulation chemistry to produce matrices or particulates in the micro-and nano-range. The presentation of core materials at the nanoscale improves target ability to specific areas of the digestive tract and gives improved control of release rate...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28605186/synthesis-of-oil-laden-poly-ethylene-glycol-diacrylate-hydrogel-nanocapsules-from-double-nanoemulsions
#6
Mengwen Zhang, Maksymilian Nowak, Paula Malo de Molina, Michael Abramovitch, Katherine Santizo, Samir Mitragotri, Matthew E Helgeson
Multiple emulsions have received great interest due to their ability to be used as templates for the production of multicompartment particles for a variety of applications. However, scaling these complex droplets to nanoscale dimensions has been a challenge due to limitations on their fabrication methods. Here, we report the development of oil-in-water-in-oil (O1/W/O2) double nanoemulsions via a two-step high-energy method and their use as templates for complex nanogels comprised of inner oil droplets encapsulated within a hydrogel matrix...
June 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28583666/safety-evaluation-of-water-soluble-palm-fruit-bioactives
#7
Barry S Lynch, Spencer West, Ashley Roberts
Water-soluble palm fruit bioactives, derived from the aqueous stream of palm oil processing, have shown anti-diabetogenic effects in rodent models. To assess the safety of potential incorporation of this polyphenol-containing material in food, in vitro bacterial reverse mutation and in vitro chromosome aberration assays were conducted along with a 90-day subchronic toxicity study in Sprague-Dawley rats. Water-soluble palm fruit bioactives were inactive in the Ames and in vitro chromosome aberration assays up to the limit doses of 5000 μg/plate and 5000 μg/mL, respectively...
June 2, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28572733/the-jordan-food-and-drug-administration-comparison-of-its-registration-process-with-australia-canada-saudi-arabia-and-singapore
#8
Wesal Salem Al Haqaish, Hayel Obeidat, Prisha Patel, Stuart Walker
OBJECTIVE: This study outlines the current regulatory review process and good review practices (GRevPs) at the Jordan Food and Drug Administration (JFDA) and compares them with those of regulatory agencies in Australia, Canada, Saudi Arabia and Singapore to gauge how well the JFDA is performing. We identify opportunities for further development of the JFDA as a key global reference agency. METHODS: Personnel within the JFDA completed a questionnaire comprising four sections: organisation, key milestones, review timelines, and GRevPs...
2017: Pharmaceutical Medicine
https://www.readbyqxmd.com/read/28559614/harvest-date-and-storage-effect-on-fruit-size-phenolic-content-and-antioxidant-capacity-of-wild-blueberries-of-nw-ontario-canada
#9
A U Mallik, J Hamilton
Blueberries are eaten fresh or after storing at room temperature, refrigerator or freezer but little is known about changes in food values of wild blueberries due to harvest dates and storage conditions. The aim of this study was to investigate the effect of harvest date and storage conditions of wild blueberries on berry quality and health related chemistry. We analyzed Vaccinium angustifolium, V. angustifolium var. nigrum, and V. myrtilloides native to NW Ontario, Canada harvested early and late in the season for total phenol (TP), anthocyanin contents (AC), and soluble solids to titratable acidity ratio storing at room temperature, refrigerator and freezer temperature...
May 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28559156/dietary-safety-assessment-of-genetically-modified-rice-eh-rich-in-%C3%AE-carotene
#10
Yangyang Wu, Yan Xu, Yanan Du, Xiao Zhao, Ruili Hu, Xiaorui Fan, Fangfang Ren, Quanhong Yao, Rihe Peng, Xueming Tang, Kai Zhao
This 90-day study aimed to assess the dietary safety of transgenic rice EH which is rich in β-carotene. Two experimental groups of Sprague-Dawley rats were fed diets containing 45% rice flour of Zhonghua 11 rice and transgenic rice EH rich in β-carotene, respectively. The reference group was fed a diet containing standard feed nutrition. During the trial period, each rat was weighed and the food intake was recorded twice a week. Their behaviors were observed daily. In the end, blood samples were obtained from all anesthetized rats to measure the hematologic and serum chemistry indicators...
May 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28542816/identification-of-microorganisms-isolated-from-counterfeit-and-unapproved-decorative-contact-lenses
#11
Adrian D Land, Katie L Penno, Jennifer L Brzezinski
All contact lenses (corrective/noncorrective) are considered Class II or Class III medical devices under the Federal Food, Drug, and Cosmetic Act, which also states that contact lenses can only be obtained with a prescription. The Forensic Chemistry Center of the US Food & Drug Administration has examined over 300 decorative, noncorrective contact lenses obtained without a prescription. Our observations indicate that 60% of the counterfeit lenses and 27% of the unapproved lenses examined were positive for microbial contamination...
May 24, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28539089/simulating-real-life-exposures-to-uncover-possible-risks-to-human-health-a-proposed-consensus-for-a-novel-methodological-approach
#12
A M Tsatsakis, D Kouretas, M N Tzatzarakis, P Stivaktakis, K Tsarouhas, K S Golokhvast, V N Rakitskii, V A Tutelyan, A F Hernandez, R Rezaee, G Chung, C Fenga, A B Engin, M Neagu, A L Arsene, A O Docea, E Gofita, D Calina, I Taitzoglou, J Liesivuori, A W Hayes, S Gutnikov, C Tsitsimpikou
In real life, consumers are exposed to complex mixtures of chemicals via food, water and commercial products consumption. Since risk assessment usually focuses on individual compounds, the current regulatory approach doesn't assess the overall risk of chemicals present in a mixture. This study will evaluate the cumulative toxicity of mixtures of different classes of pesticides and mixtures of different classes of pesticides together with food additives (FAs) and common consumer product chemicals using realistic doses after long-term exposure...
June 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28533770/from-vineyard-soil-to-wine-fermentation-microbiome-approximations-to-explain-the-terroir-concept
#13
REVIEW
Ignacio Belda, Iratxe Zarraonaindia, Matthew Perisin, Antonio Palacios, Alberto Acedo
Wine originally emerged as a serendipitous mix of chemistry and biology, where microorganisms played a decisive role. From these ancient fermentations to the current monitored industrial processes, winegrowers and winemakers have been continuously changing their practices according to scientific knowledge and advances. A new enology direction is emerging and aiming to blend the complexity of spontaneous fermentations with industrial safety of monitored fermentations. In this context, wines with distinctive autochthonous peculiarities have a great acceptance among consumers, causing important economic returns...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28532533/glycaemic-index-and-glycaemic-load-values-of-commonly-consumed-foods-in-the-united-arab-emirates
#14
Ayesha S Al Dhaheri, C Jeyakumar K Henry, Maysm N Mohamad, Eric O Ohuma, Leila Cheikh Ismail, Fatima T Al Meqbaali, Amjad H Jarrar
Glycaemic index (GI) and glycaemic load (GL) values of some commonly consumed foods in the United Arab Emirates were determined with an aim of adding these values to the existing international table of GI and GL values. In all, eighteen test foods categorised into breads (n 5), entrée dishes (n 3), main dishes (n 5) and sweet dishes (n 5) were tested. For each test food, at least fifteen healthy participants consumed 25 or 50 g available carbohydrate portions of a reference food (glucose), which was tested three times, and a test food after an overnight fast, was tested once, on separate occasions...
May 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28522334/safety-evaluation-of-chlorella-sorokiniana-strain-ck-22-based-on-an-in%C3%A2-vitro-cytotoxicity-assay-and-a-13-week-subchronic-toxicity-trial-in-rats
#15
Sayaka Himuro, Sugi Ueno, Naoto Noguchi, Takuya Uchikawa, Toshihiro Kanno, Akira Yasutake
The genus Chlorella contains unicellular green algae that have been used as food supplements. The purpose of this work was to evaluate the safety of the Chlorella sorokiniana strain CK-22 using powdered preparation (CK-22P) both by in vitro and in vivo assays. These included an experiment for cytotoxicity using Chinese hamster lung fibroblasts (V79 cells) and a 13-week repeated-dose oral toxicity trial using Wistar rats. The cytotoxicity was evaluated by MTT assay of a hot water extract (Hw-Ex) and 80% ethanol extract (Et-Ex) of CK-22P, and no effect on cell viability was observed...
May 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28518086/ptr-tof-ms-coupled-with-an-automated-sampling-system-and-tailored-data-analysis-for-food-studies-bioprocess-monitoring-screening-and-nose-space-analysis
#16
Vittorio Capozzi, Sine Yener, Iuliia Khomenko, Brian Farneti, Luca Cappellin, Flavia Gasperi, Matteo Scampicchio, Franco Biasioli
Proton Transfer Reaction (PTR), combined with a Time-of-Flight (ToF) Mass Spectrometer (MS) is an analytical approach based on chemical ionization that belongs to the Direct-Injection Mass Spectrometric (DIMS) technologies. These techniques allow the rapid determination of volatile organic compounds (VOCs), assuring high sensitivity and accuracy. In general, PTR-MS requires neither sample preparation nor sample destruction, allowing real time and non-invasive analysis of samples. PTR-MS are exploited in many fields, from environmental and atmospheric chemistry to medical and biological sciences...
May 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28512003/towards-a-sustainable-biobased-industry-highlighting-the-impact-of-extremophiles
#17
REVIEW
Anna Krüger, Christian Schäfers, Carola Schröder, Garabed Antranikian
The transition of the oil-based economy towards a sustainable economy completely relying on biomass as renewable feedstock requires the concerted action of academia, industry, politics and civil society. An interdisciplinary approach of various fields such as microbiology, molecular biology, chemistry, genetics, chemical engineering and agriculture in addition to cross-sectional technologies such as economy, logistics and digitalization is necessary to meet the future global challenges. The genomic era has contributed significantly to the exploitation of naturés biodiversity also from extreme habitats...
May 13, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28511864/metabolism-and-disposition-of-14-c-methycyclosiloxanes-in-rats
#18
Jeanne Y Domoradzki, Christopher M Sushynski, Jacob M Sushynski, Debra A McNett, Cynthia Van Landingham, Kathleen P Plotzke
Octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) are low molecular weight cyclic volatile methyl siloxanes (cVMSs) primarily used as intermediates or monomers in the production of high molecular weight silicone polymers. The use of D4 as a direct ingredient in personal care products has declined significantly over the past 10 years, although it may be present as a residual impurity in a variety of consumer products. D5 is still used as an intentional ingredient in cosmetics, consumer products and in dry cleaning...
May 13, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28507406/evaluation-of-different-agroindustrial-waste-on-the-effect-of-different-carcass-characteristics-and-physiological-and-biochemical-parameters-in-broilers-chicken
#19
Y Sánchez-Roque, Y D C Pérez-Luna, E Pérez-Luna, R Berrones Hernández, S Saldaña-Trinidad
AIM: This study was conducted to evaluate the physiological and biochemical effect in chickens of the Ross breed of a food enriched with agroindustrial waste. MATERIALS AND METHODS: The food is one of the main components of the total cost for the production of chickens. Rations should be formulated to provide the correct balance of energy, protein, amino acids, minerals, vitamins and essential fatty acids, to allow optimal growth and performance. This study was intended to evaluate a natural feed for chicken, made from corn, yucca meal, eggshells, orange peel, soybean meal, salt and garlic, enriched with agroindustrial waste (molasses, milk whey and ferment of coffee)...
April 2017: Veterinary World
https://www.readbyqxmd.com/read/28503266/inhalation-toxicity-of-bisphenol-a-and-its-effect-on-estrous-cycle-spatial-learning-and-memory-in-rats-upon-whole-body-exposure
#20
Yong Hyun Chung, Jeong Hee Han, Sung-Bae Lee, Yong-Hoon Lee
Bisphenol A (BPA) is a monomer used in a polymerization reaction in the production of polycarbonate plastics. It has been used in many consumer products, including plastics, polyvinyl chloride, food packaging, dental sealants, and thermal receipts. However, there is little information available on the inhalation toxicity of BPA. Therefore, the aim of this study was to determine its inhalation toxicity and effects on the estrous cycle, spatial learning, and memory. Sprague-Dawley rats were exposed to 0, 10, 30, and 90 mg/m(3) BPA, 6 hr/day, 5 days/week for 8 weeks via whole-body inhalation...
April 2017: Toxicological Research
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