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https://www.readbyqxmd.com/read/29140581/comparison-of-long-term-outcomes-between-pull-through-resection-and-mandibular-lip-split-surgery-for-t4a-tongue-floor-of-mouth-cancers
#1
Shih-Jung Cheng, Hui-Hsin Ko, Jang-Jaer Lee, Sang-Heng Kok
BACKGROUND: The purpose of this study was to determine whether the pull-through resection is better than the mandibular lip-split for advanced tongue/floor of mouth (FOM) cancers, which remains inconclusive. METHODS: A retrospective cohort study was performed on 91 patients with T4a tongue/FOM cancers from 2009 to 2014. Cases with mandibular resection were excluded. The pull-through resection was used when the mouth opening was ≥15 mm; otherwise the mandibular lip-split was used...
November 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/29138321/in-vivo-bioluminescence-imaging-of-labile-iron-accumulation-in-a-murine-model-of-acinetobacter-baumannii-infection
#2
Allegra T Aron, Marie C Heffern, Zachery R Lonergan, Mark N Vander Wal, Brian R Blank, Benjamin Spangler, Yaofang Zhang, Hyo Min Park, Andreas Stahl, Adam R Renslo, Eric P Skaar, Christopher J Chang
Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in labile forms that can contribute to oxidative stress, is connected to diseases ranging from infection to cancer to neurodegeneration. Iron deficiency is also among the most common nutritional deficiencies worldwide. To advance studies of iron in healthy and disease states, we now report the synthesis and characterization of iron-caged luciferin-1 (ICL-1), a bioluminescent probe that enables longitudinal monitoring of labile iron pools (LIPs) in living animals...
November 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29094488/maternal-report-of-fever-from-cold-or-flu-during-early-pregnancy-and-the-risk-for-noncardiac-birth-defects-national-birth-defects-prevention-study-1997-2011
#3
Dorothy Kim Waller, Syed Shahrukh Hashmi, Adrienne T Hoyt, Hao T Duong, Sarah C Tinker, Michael Shayne Gallaway, Richard S Olney, Richard H Finnell, Jacqueline Tauber Hecht, Mark A Canfield
BACKGROUND: As maternal fever affects approximately 6-8% of early pregnancies, it is important to expand upon previous observations of an association between maternal fever and birth defects. METHODS: We analyzed data from the National Birth Defects Prevention Study, a multistate, case-control study of major structural birth defects. Telephone interviews were completed by mothers of cases (n = 17,162) and controls (n = 10,127). Using multivariable logistic regression, we assessed the association between maternal self-report of cold or flu with fever and cold or flu without fever during early pregnancy and 30 categories of non-cardiac birth defects...
November 2, 2017: Birth defects research
https://www.readbyqxmd.com/read/29049191/significance-of-monitoring-plasma-concentration-of-voriconazole-in-a-patient-with-liver-failure-a-case-report
#4
Xiaoyan Liu, Haibin Su, Jingjing Tong, Jing Chen, Haozhen Yang, Long Xiao, Jinhua Hu, Lina Zhang
RATIONALE: Invasive pulmonary aspergillosis is associated with significant morbidity and mortality in patients with liver failure. Voriconazole (VRCZ) is recommended as a primary therapeutic agent for the treatment of invasive aspergillosis and metabolized in the liver. Now, data are still lacking on the safety and appropriate dosage of VRCZ in patients with liver failure. Here, we report a representative case of invasive pulmonary fungal infection in a patient with liver failure who was treated with low-dose VRCZ...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29031574/a-new-all-purpose-bilateral-cleft-lip-repair-bilateral-cheiloplasty-suitable-for-most-conditions
#5
Rong-Min Baek, Yujin Myung, Iehyon Park, Chang-Sik Pak, Baek-Kyu Kim, Vũ Ngọc Lâm, Jae Hoon Jeong
BACKGROUND: Only experienced surgeons can produce satisfactory results with most of the current surgical methods for bilateral cleft lip repair. The existing methods require not only preoperative orthodontic maneuvers but also accurate measurements for surgical design. We describe an easy-to-design and simple-to-execute general purpose surgical technique to repair most bilateral cleft lips. METHODS: A retrospective review was performed for the patients who underwent bilateral cleft lip repair using our novel method between 2003 and 2016...
September 25, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28960348/low-viral-load-of-merkel-cell-polyomavirus-in-iranian-patients-with-head-and-neck-squamous-cell-carcinoma-is-it-clinically-important
#6
Elham Mohebbi, Zahra Noormohamadi, Habib Sadeghi-Rad, Farzin Sadeghi, Yousef Yahyapour, Farzam Vaziri, Ayoub Rahimi, Fatemeh Rahimi Jamnani, Saman Mehrabi, Seyed D Siadat, Mohammad R Noori-Daloii, Abolfazl Fateh
Recent studies show that the human Merkel cell polyomavirus (MCPyV) may be involved in causing cancer. The objective of this study was to assess the impact of MCPyV on the development of head and neck squamous cell carcinoma (HNSCC). In total, 50 paraffin-embedded HNSCC biopsy samples and 50 adjacent non-cancerous samples were evaluated for the presence of MCPyV DNA and RNA. Among patients, the five most frequent histopathologic sites were the tongue (22.0%), lip (16.0%), submandibular (14.0%), cheek (14.0%), and throat (14...
September 28, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28955585/melkersson-rosenthal-syndrome-a-case-report
#7
Adil Basman, Mustafa Gumusok, Serife Degerli, Mustafa Kaya, Meryem Toraman Alkurt
Melkersson-Rosenthal Syndrome (MRS) is a rare disorder consisting of a triad of persistent or recurrent orofacial edema, relapsing facial paralysis and fissured tongue. It is rarely possible to observe all aspects of the classical triad at the same time, since these symptoms may appear in different times of life cycle. The most common symptom is orofacial edema. Although etiology of MRS is unclear, various factors such as infections, genetic predisposition, immune deficiency, food intolerance and stress have been held responsible...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/28953729/reinforcing-the-mucoperiosteal-pocket-with-the-scarpa-fascia-graft-in-secondary-alveolar-bone-grafting-a-retrospective-controlled-outcome-study
#8
Daniel Lonic, Kazuaki Yamaguchi, Betty Chien-Jung Pai, Lun-Jou Lo
BACKGROUND: Secondary alveolar bone grafting is the gold standard for the treatment of alveolar clefts in cleft lip and palate patients. The authors present a modified method using a Scarpa fascia graft that is placed deep into the mucoperiosteal pocket for watertight sealing of the bone graft chamber and limiting the graft position to the alveolar region for bony stability and tooth support. The outcome was assessed for clinical success in terms of bone graft stability and infection rate...
October 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28953630/orofacial-granulomatosis-a-case-report-of-three-cases-may-be-caused-by-apical-periodontitis
#9
Wenyi Zhang, Jia Wang, Xixi Yu, Wanchun Wang
RATIONALE: Orofacial granulomatosis (OFG) is a rare disease characterized by noncaseating granulomatous inflammation. The most common clinical presentation is persistent swelling of the soft tissues in the oral and maxillofacial regions. The precise cause of OFG is unknown. Corticosteroids are the first-line and best treatment, but there is lack of uniform treatment prescription and standard. It is important to identify the pathogen in order to improve treatment specificity. PATIENT CONCERNS: Three patients presented with recurring lip swelling and cobblestone formation on buccal mucosa, complained of toothache or dental caries for many years...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28921566/pegylation-of-cationic-liposomes-encapsulating-soluble-leishmania-antigens-reduces-the-adjuvant-efficacy-of-liposomes-in-murine-model
#10
H Naseri, F Eskandari, M R Jaafari, A Khamesipour, A Abbasi, A Badiee
Although there have been several attempts to develop a vaccine against leishmaniasis, no vaccine in human has been developed yet. Liposomes consisting of 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP) encapsulating soluble Leishmania antigens (SLA) enhance protective immunity of SLA against Leishmania major infection in mice. However, they immobilized at the injection site because of their positive charge. To overcome the problem, shielding the surface charge with polyethylene glycol (PEGylation) was chosen in this study...
November 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28894361/effects-of-daily-vitamin-d-supplementation-on-respiratory-muscle-strength-and-physical-performance-in-vitamin-d-deficient-copd-patients-a-pilot-trial
#11
Rachida Rafiq, Hendrik J Prins, Wim G Boersma, Johannes Ma Daniels, Martin den Heijer, Paul Lips, Renate T de Jongh
BACKGROUND: Although vitamin D is well known for its function in calcium homeostasis and bone mineralization, several studies have shown positive effects on muscle strength and physical function. In addition, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients, supplementation might have a beneficial effect in these patients. OBJECTIVE: To assess the effect of vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28862467/clinical-imaging-and-laboratory-findings-in-sj%C3%A3-gren-s-syndrome
#12
Aruanda Fiche, Alynne Vieira Menezes, Claudia Scigliano Valerio, Martinho Campolina Rebello Horta, Flávio Ricardo Manzi
Sjögren's syndrome (SS) is a rare condition characterized by structural damage and secretory dysfunction of the lacrimal and salivary glands that leads to dryness, particularly xerophthalmia (eyes) and xerostomia (mouth). No cure is known; however, the effects of the disease are manageable and symptoms may be reduced. Although the salivary damage is irreversible, the dental decay and oral infections may be prevented, which highlights the importance that the clinician plays in the diagnosis and management of SS...
September 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28860684/experience-of-the-posterior-lip-augmentation-device-in-a-regional-hip-arthroplasty-unit-as-a-treatment-for-recurrent-dislocation
#13
L Hoggett, C Cross, T Helm
INTRODUCTION: Dislocation after total hip arthroplasty (THA) remains a significant complication of the procedure and is the third leading cause for revision THA. One technique for treatment of this complication is the use of the posterior lip augmentation device (PLAD). We describe our experience using the PLAD including complication rates. METHODS: A retrospective review of 55 PLADs (54 patients) was carried out following identification from electronic theatre records...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28856588/whole-blood-microrna-markers-are-associated-with-acute-respiratory-distress-syndrome
#14
Zhaozhong Zhu, Liming Liang, Ruyang Zhang, Yongyue Wei, Li Su, Paula Tejera, Yichen Guo, Zhaoxi Wang, Quan Lu, Andrea A Baccarelli, Xi Zhu, Ednan K Bajwa, B Taylor Thompson, Guo-Ping Shi, David C Christiani
BACKGROUND: MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS. METHODS: This nested case-control study (N = 530) examined a cohort of ARDS patients and critically ill at-risk controls. Whole blood miRNA profiles and logistic regression analyses identified miRNAs correlated with ARDS...
August 30, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28854186/meloidogyne-aberrans-sp-nov-nematoda-meloidogynidae-a-new-root-knot-nematode-parasitizing-kiwifruit-in-china
#15
Ye Tao, Chunling Xu, Chunfen Yuan, Honghong Wang, Borong Lin, Kan Zhuo, Jinling Liao
High infection rates of roots of wild kiwifruit (Actinidia chinensis Planch) and soil infestation by a root-knot nematode were found in Anshun, GuiZhou Province, China. Morphology, esterase phenotype and molecular analyses confirmed that this nematode was different from previously described root-knot nematodes. In this report, the species is described, illustrated and named Meloidogyne aberrans sp. nov. The new species has a unique combination of characters. A prominent posterior protuberance, round and faint perineal pattern and a medium-length stylet (13...
2017: PloS One
https://www.readbyqxmd.com/read/28827990/amoxycillin-and-clavulanic-acid-induced-stevens-johnson-syndrome-a-case-report
#16
Maheen Zaidi, Syeda Kashaf Zaidi, Moomal Bhutto, Mohammad Yasir Umer
Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. In this case report, a 32 year old female reported chief complaint of itch skin eruptions all over the body along with erosive lesions on tongue, lips, buccal mucosa and genital mucosa...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28827297/herpes-simplex-transmission-to-chest-and-face-through-autoinoculation-in-an-infant
#17
Jeroen J van Vonderen, Kim Stol, Emmeline P Buddingh, Danielle Cm van der Kaay
A 4-month-old female infant presented with a vesicular lesion on her left hand present since 1 day. A few days prior to presentation, she had a similar lesion on the lower lip. Two days after presentation, she returned with new lesions on her thorax and upper eyelid. PCR of the vesicle was positive for herpes simplex virus type 1. The transmission to her chest and face probably resulted from autoinoculation, caused by rubbing of the hand on other parts of the body. Transmission of herpes simplex through skin-to-skin contact is a common route of infection in people engaging in contact sports...
August 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28821241/genetic-diversity-and-virulence-potential-of-clinical-and-environmental-aeromonas-spp-isolates-from-a-diarrhea-outbreak
#18
Lívia Christina Alves da Silva, Tereza Cristina Leal-Balbino, Beatriz Souza Toscano de Melo, Carina Lucena Mendes-Marques, Antonio Mauro Rezende, Alzira Maria Paiva de Almeida, Nilma Cintra Leal
BACKGROUND: Aeromonas spp. are gram-negative bacteria that can cause a variety of infections in both humans and animals and play a controversial role in diarrhea outbreaks. Our aim was to identify clinical and environmental Aeromonas isolates associated with a cholera outbreak in a northeast county of Brazil at the species level. We also aimed to determine the genetic structure of the bacterial population and the virulence potential of the Aeromonas isolates. METHODS AND RESULTS: Analysis based on concatenated sequences of the 16S rRNA and gyrB genes suggested the classification of the 119 isolates studied into the following species: A...
August 18, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28819616/maternal-risk-factors-associated-with-the-development-of-cleft-lip-and-cleft-palate-in-mexico-a-case-control-study
#19
Emmanuel Angulo-Castro, Luis F Acosta-Alfaro, Alma M Guadron-Llanos, Adrian Canizalez-Román, Fernando Gonzalez-Ibarra, Ignacio Osuna-Ramírez, Joel Murillo-Llanes
INTRODUCTION: Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. MATERIALS AND METHODS: We conducted a case control study at the Women's Hospital in Culiacan, Mexico. Medical records were analyzed, including patients who delivered babies with and without cleft lip and cleft palate from January 2010 to December 2015...
July 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28816718/double-composite-tissue-z-plasty-technique-for-anatomical-restoration-of-severe-nasal-deformity-in-secondary-unilateral-cleft-lip
#20
Jiao Wei, Tanja Herrler, Hua Xu, Qingfeng Li, Chuanchang Dai
BACKGROUND: Patients with secondary unilateral cleft lip are regularly affected by serious nasal deformities especially of the alar and nasal floor. A large number of techniques for correction have been published, but symmetrical restoration of severe nasal deformation is difficult to achieve. We propose an innovative approach for anatomical restoration for this entity of nasal deformities to achieve long-term symmetrical appearance and muscular function. METHODS: A total of 68 patients with severe nasal deformity due to secondary unilateral cleft lip underwent reconstructive surgery using a double composite tissue Z-plasty technique for anatomical restoration of cartilage, muscle, and soft tissue layers...
October 2017: Annals of Plastic Surgery
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