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https://www.readbyqxmd.com/read/28098046/monitoring-the-effects-of-iodine-prophylaxis-in-the-adult-population-of-southern-italy-with-deficient-and-sufficient-iodine-intake-levels-a-cross-sectional-epidemiological-study
#1
Daniela Bonofiglio, Stefania Catalano, Anna Perri, Marta Santoro, Lorenza Siciliano, Danilo Lofaro, Massimiliano Gallo, Stefania Marsico, Rosalinda Bruno, Cinzia Giordano, Ines Barone, Sebastiano Andò
I prophylaxis is the most effective strategy to eradicate I deficiency disorders, but it has been shown to affect the thyroid disease pattern. In this study, we assessed the frequency of thyroid disorders in an adult population living in two areas of southern Italy after implementing I prophylaxis. To this aim, a cross-sectional, population-based study including 489 subjects from an I-deficient rural and an I-sufficient urban area of southern Italy was conducted. Thyroid ultrasound was performed on all participants, and urine and blood samples were collected from each subject...
January 18, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28097455/leptin-npy-melatonin-and-zinc-levels-in-experimental-hypothyroidism-and-hyperthyroidism-the-relation-to-zinc
#2
Abdulkerim Kasım Baltaci, Rasim Mogulkoc
Since zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats...
January 17, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28097176/a-comparison-between-the-quality-of-life-and-mental-health-of-patients-with-hypothyroidism-and-normal-people-referred-to-motahari-clinic-of-shiraz-university-of-medical-sciences
#3
Mahnaz Rakhshan, Alireza Ghanbari, Atefeh Rahimi, Issac Mostafavi
BACKGROUND: Hypothyroidism is a condition caused by a decrease in the thyroid gland hormones. This disease is very common at all age ranges. Regarding its long term therapeutic procedure, this disease can affect the quality of life and the mental health of the patients. The present study aimed to compare the quality of life and mental health in hypothyroid patients and normal people. METHODS: This descriptive-analytic investigation was performed using convenience sampling on 95 patients with hypothyroidism and 95 normal cases referring to Motahari clinic between October 2014 and August 2015...
January 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28095748/myocardial-inactivation-of-thyroid-hormones-in-patients-with-aortic-stenosis
#4
Bruno Paolino, Pablo Maria Pomerantzeff, Luiz Alberto O Dallan, Fabio Antonio Gaiotto, Nailliw Zanini Preite, Ana Claudia Latronico, Jose Carlos Nicolau, Antonio Carlos Bianco, Roberto Giraldez
OBJECTIVE: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. CONTEXT: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 deiodinase (D3) has been found in a rat model of right ventricular hypertrophy. It is not known whether the human myocardium metabolizes thyroid hormone...
January 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28095042/gauging-the-extent-of-thyroidectomy-for-indeterminate-thyroid-nodules-an-oncologic-perspective
#5
David F Schneider, Linda M Cherney Stafford, Nicole Brys, Caprice C Greenberg, Courtney J Balentine, Dawn M Elfenbein, Susan C Pitt
INTRODUCTION: Increasing emphasis is being placed on appropriateness of care and avoidance of over- and under-treatment. Indeterminate thyroid nodules (ITN), present a particular risk for this problem because cancer found via diagnostic lobectomy (DL) often requires a completion thyroidectomy (CT). However, initial total thyroidectomy (TT) for benign ITN results in lifelong thyroid hormone replacement. We sought to measure the accuracy and factors associated with the extent of initial thyroidectomy for ITN...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28093992/effects-of-thyroid-hormones-and-their-metabolites-on-learning-and-memory-in-normal-and-pathological-conditions
#6
Alice Accorroni, Grazia Chiellini, Nicola Origlia
BACKGROUND: Classical thyroid hormones have an established necessary role in the normal development of the central nervous system, and they have been recently considered as decisive factors influencing cognitive functions in adult brain and involved in the development of Alzheimer's disease. The picture summarizing thyroid hormone effects on adult brain, however, does not only include classical thyroid hormones but also the products of their peripheral metabolism. These latter have been considered as inactive breakdown products for long but recently were proved to produce significant biological effects...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28092700/association-between-thyroid-autoimmunity-and-helicobacter-pylori-infection
#7
Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Background/Aims: There have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed this study to investigate the association between H. pylori infection and AITD in Koreans. Methods: This study involved adults aged 30 to 70 years who had visited a health promotion center...
January 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28092021/sunshine-vitamin-and-thyroid
#8
REVIEW
Immacolata Cristina Nettore, Luigi Albano, Paola Ungaro, Annamaria Colao, Paolo Emidio Macchia
Vitamin D exerts its canonical roles on the musculoskeletal system and in the calcium/phosphorus homeostasis. In the last years, increasing evidences suggested several extra-skeletal actions of this hormone, indicating that vitamin D may produce effects in almost all the body tissues. These are mediated by the presence of vitamin D receptor (VDR) and thanks to the presence of the 1-α-hydroxylase, the protein that converts the 25-hydroxyvitamin (calcidiol) to the active form 1,25-dihydroxyvitamin (calcitriol)...
January 14, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28090515/a-systematic-review-of-combinatorial-treatment-with-warming-and-invigorating-drugs-and-levothyroxine-for-hypothyroidism-caused-by-hashimoto-disease
#9
Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
BACKGROUND: We used the systematic review method to evaluate the clinical efficacy and safety of combinatorial treatment with warming and invigorating drugs and levothyroxine on hypothyroidism caused by Hashimoto thyroiditis (HT). METHODS: We set inclusion and exclusion criteria, searched for studies using electronic databases and manual retrieval, selected studies according to the inclusion and exclusion criteria, and assessed the qualities of the included studies according to the Jadad scale...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090499/risk-factors-associated-with-high-thyroglobulin-level-following-radioactive-iodine-ablation-measured-12-months-after-treatment-for-papillary-thyroid-carcinoma
#10
Eun Young Kim, Kee Hoon Hyun, Yong Lai Park, Chan Heun Park, Ji-Sup Yun
PURPOSE: The measurement of serum thyroglobulin (Tg) of papillary thyroid carcinoma patients, 12 months after total thyroidectomy and radioactive iodine (RAI) ablation following thyroxine hormone withdrawal (T4-off Tg) or recombinant human thyroid-stimulating hormone stimulation (rhTSH-Tg), is standard method for monitoring disease status. The aim of this study was to find predictive factors for detectable T4-off Tg during follow-up. METHODS: A retrospective review was conducted of 329 patients who underwent total thyroidectomy and RAI ablation between October 2008 and August 2012...
January 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28089823/thyroid-hormones-and-browning-of-adipose-tissue
#11
Juliane Weiner, Mohammed Hankir, John T Heiker, Wiebke Fenske, Kerstin Krause
Thyroid hormone (TH) disorders are associated with profound changes in whole body energy metabolism. A major TH target is thermogenic brown adipose tissue (BAT), which can be stimulated directly through thyroid hormone receptors (TRs) expressed in brown adipocytes and indirectly, through TRs expressed in hypothalamic neurons. White adipose tissue (WAT) adopts BAT characteristics by a diverse range of stimuli in a process referred to as browning. It is now understood that TH also induce WAT browning through peripheral and central mechanisms...
January 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28089504/review-nutrient-sulfate-supply-from-mother-to-fetus-placental-adaptive-responses-during-human-and-animal-gestation
#12
REVIEW
P A Dawson, K Richard, A Perkins, Z Zhang, D G Simmons
Nutrient sulfate has numerous roles in mammalian physiology and is essential for healthy fetal growth and development. The fetus has limited capacity to generate sulfate and relies on sulfate supplied from the maternal circulation via placental sulfate transporters. The placenta also has a high sulfate requirement for numerous molecular and cellular functions, including sulfate conjugation (sulfonation) to estrogen and thyroid hormone which leads to their inactivation. Accordingly, the ratio of sulfonated (inactive) to unconjugated (active) hormones modulates endocrine function in fetal, placental and maternal tissues...
January 4, 2017: Placenta
https://www.readbyqxmd.com/read/28088877/the-concerted-action-of-type-2-and-type-3-deiodinases-regulates-the-cell-cycle-and-survival-of-basal-cell-carcinoma-cells
#13
Caterina Miro, Raffaele Ambrosio, Maria Angela De Stefano, Daniela Di Girolamo, Emery Di Cicco, Annunziata Gaetana Cicatiello, Giuseppina Mancino, Tommaso Porcelli, Maddalena Raia, Luigi Del Vecchio, Domenico Salvatore, Monica Dentice
BACKGROUND: Thyroid hormones (THs) mediate pleiotropic cellular processes involved in metabolism, cellular proliferation and differentiation. The intracellular hormonal environment can be tailored by the deiodinase enzymes, D2 and D3, which catalyze TH activation and inactivation, respectively. In many cellular systems, THs exert well documented stimulatory or inhibitory effects on cell proliferation, however, the molecular mechanisms by which they control rates of cell cycle progression have not yet been entirely clarified...
January 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28088629/induction-of-hypothyroidism-during-early-postnatal-stages-triggers-a-decrease-in-cognitive-performance-by-decreasing-hippocampal-synaptic-plasticity
#14
Paulina Salazar, Pedro Cisternas, Juan Francisco Codocedo, Nibaldo C Inestrosa
Thyroid hormones are vital in the control of multiple body functions, including the correct performance of the brain. Multiple diseases are associated with thyroid gland functioning, including hypothyroidism. To date, little is known regarding the effects of the establishment of this condition at a young age on brain function. Here, we evaluated the effect of hypothyroidism in an early postnatal stage in cognitive abilities with focus on the hippocampus. In our model, hypothyroidism was induced in young rats at 21days of age using 0...
January 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28088468/hypothalamic-effects-of-thyroid-hormone
#15
Zhi Zhang, Anita Boelen, Peter H Bisschop, Andries Kalsbeek, Eric Fliers
Thyroid hormone (TH) is a key driver of metabolism in mammals. Plasma concentrations of TH are kept within a narrow range by negative feedback regulation in the hypothalamus-pituitary-thyroid (HPT) axis. Plasma TH concentrations are an important determinant of metabolic processes in liver and brown adipose tissue (BAT). In addition to endocrine effects of TH derived from the circulation, recent studies have demonstrated additional neural routes for intrahypothalamic thyroid hormone to regulate metabolism in liver and BAT via the sympathetic and parasympathetic branch of the autonomic nervous system (ANS)...
January 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28088465/neuronal-effects-of-thyroid-hormone-metabolites
#16
Eva K Wirth, Franziska Meyer
Thyroid hormones and their metabolites are active regulators of gene expression, mitochondrial function and various other physiological actions in different organs and tissues. These actions are mediated by a spatio-temporal regulation of thyroid hormones and metabolites within a target cell. This spatio-temporal resolution as well as classical and non-classical actions of thyroid hormones and metabolites is accomplished and regulated on multiple levels as uptake, local activation and signaling of thyroid hormones...
January 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28081173/effect-of-rifampin-on-thyroid-function-test-in-patients-on-levothyroxine-medication
#17
Hye In Kim, Tae Hyuk Kim, Hosu Kim, Young Nam Kim, Hye Won Jang, Jae Hoon Chung, Seong Mi Moon, Byung Woo Jhun, Hyun Lee, Won-Jung Koh, Sun Wook Kim
BACKGROUND: Levothyroxine (LT4) and rifampin (RIF) are sometimes used together; however, no clinical studies have assessed the effects of these drugs on thyroid function or the need to adjust LT4 dose. METHODS: We retrospectively reviewed the records of 71 Korean patients who started RIF during LT4 treatment. Clinically relevant cases that required dose adjustment according to the American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) guidelines were identified, and risk factors of increased LT4 dose were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28080155/safety-of-interferon-alpha-2a-in-patients-with-severe-ophthalmic-beh%C3%A3-et-s-disease-response-to-bielefeld-et-al-s-letter
#18
Mohammed El Amine Ghembaza, Ali Lounici
Thyroid dysfunction is a common and severe side-effect encountered in up to 40% of patients treated with IFN-alpha-2a. The main two mechanisms by which IFN-alpha-2a induces thyroid dysfunction can be categorized as autoimmune and non-autoimmune disease. In the first subgroup, thyroid antibodies are found before treatment initiation, and then patients develop thyroiditis. In the second subgroup, IFN-alpha-2a induces thyroiditis by a direct cytotoxic effect on the thyroid gland; in this case, thyroid antibodies are usually negative...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28079402/sexual-dysfunction-in-premenopausal-women-could-be-related-to-hormonal-profile
#19
Fabiene Bernardes Castro Vale, Bruna Barbosa Coimbra, Gerson Pereira Lopes, Selmo Geber
Female sexual dysfunction (FSD) is a public health problem that affects women's quality of life. Although the relationship between some hormones and the FSD has been described, it is not well established for all hormones. Therefore, the aim of our study was to evaluate the association between hormonal dysfunction and sexual dysfunction in premenopausal women. We performed a cross-sectional study with 60 patients with regular menstrual cycles, with age ranging from 18 to 44 years, with previous diagnosis of FSD...
January 12, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28079354/effect-of-excess-iodine-intake-on-thyroid-on-human-health
#20
Eftychia G Koukkou, Nikolaos D Roupas, Kostas B Markou
INTRODUCTION: The recommended daily intake of iodide, is 150 μg for adolescents and adults, 175 μg for pregnancy and 200 μg for lactation. Thyroid gland is an effective collector of iodine. EVIDENCE ACQUISITION: The active iodine uptake along the basolateral membrane of thyroid cell is followed by its transport to the apical edge of the cell and then to the follicle lumen. TSH acts through cAMP and stimulates NIS gene expression and protein synthesis. The major proportion of iodine in the thyroid gland is bound to Thyroglobulin...
January 12, 2017: Minerva Medica
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