keyword
https://read.qxmd.com/read/38521900/increased-di-2-ethylhexyl-phthalate-exposure-poses-a-differential-risk-for-adult-asthma-clusters
#21
JOURNAL ARTICLE
Yuan-Ting Hsu, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Yi-Hsin Yang, Ming-Yen Cheng, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Yung-Fa Lai, Meng-Hsuan Cheng, Huang-Chi Chen, Chih-Jen Yang, Chien-Jen Wang, Huei-Ju Liu, Hua-Ling Chen, Chih-Hsing Hung, Chon-Lin Lee, Ming-Shyan Huang, Shau-Ku Huang
BACKGROUND: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology. METHODS: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions...
March 23, 2024: Respiratory Research
https://read.qxmd.com/read/38521434/biotoxicity-responses-of-zebrafish-in-environmentally-relevant-concentration-of-di-2-ethylhexyl-phthalate
#22
JOURNAL ARTICLE
Xianxu Li, Shichang Hu, Nan Jiang, Xiangfeng Yao, Can Wang, Qian Wang, Zhongkang Yang, Jun Wang
As an emerging environmental contaminant, di (2-ethylhexyl) phthalate (DEHP) is widely present in the aquatic environment, however, the effects and underlying mechanisms of DEHP on the aquatic organisms are poorly understood. This study systematically investigated the ecotoxicity induced by chronic exposure to environmental relevant concentrations of DEHP (0.03mg/L, 0.1mg/L, and 0.3mg/L) on zebrafish brain. Results indicated that DEHP exposure significantly increased the levels of ROS and disturbance of the antioxidant enzymes activities in the brain, which may further enhance lipid peroxidation and DNA damage...
March 21, 2024: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/38521262/dimethyl-phthalate-induced-cardiovascular-developmental-toxicity-in-zebrafish-embryos-by-regulating-mapk-and-calcium-signaling-pathways
#23
JOURNAL ARTICLE
Bianneng Cao, Haotian Kong, Chuanlin Shen, Gaimei She, Shuimiao Tian, Haojie Liu, Lishuang Cui, Yun Zhang, Qiuxia He, Qing Xia, Kechun Liu
Dimethyl phthalate (DMP), the lowest-molecular-weight phthalate ester (PAE), is one of the most commonly detected persistent organic pollutants in the environment, but its toxic effects, especially cardiovascular developmental toxicity, are largely unknown. In this study, zebrafish embryos were exposed to sublethal concentrations of DMP from 4 to 96 hpf. Our results showed that DMP treatment induced yolk retention, pericardial edema, and swim bladder deficiency, as well as increased SV-BA distance and decreased heart rate, stroke volume, ventricular axis shortening rate and ejection fraction...
March 21, 2024: Science of the Total Environment
https://read.qxmd.com/read/38520761/novel-triterpenoid-pyrones-phthalimides-and-phthalates-are-selectively-cytotoxic-in-ccrf-cem-cancer-cells-synthesis-potency-and-mitochondrial-mechanism-of-action
#24
JOURNAL ARTICLE
Anna Kazakova, Ivo Frydrych, Nikola Jakubcová, Jan Pokorný, Barbora Lišková, Soňa Gurská, Petr Džubák, Marián Hajdúch, Milan Urban
A series of triterpenoid pyrones was synthesized and subsequently modified to introduce phthalimide or phthalate moieties into the triterpenoid skeleton. These compounds underwent in vitro cytotoxicity screening, revealing that a subset of six compounds exhibited potent activity, with IC50 values in the low micromolar range. Further biological evaluations, including Annexin V and propidium iodide staining experiment revealed, that all compounds induce selective apoptosis in cancer cells. Measurements of mitochondrial potential, cell cycle analysis, and the expression of pro- and anti-apoptotic proteins confirmed, that apoptosis was mediated via the mitochondrial pathway...
March 18, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38518838/environmental-toxicants-and-nephrotoxicity-implications-on-mechanisms-and-therapeutic-strategies
#25
REVIEW
Rachna Yadav, Dinesh Kumar, Jiten Singh, Ashok Jangra
Kidneys are one of the most important organs in the human body. In addition to filtering 200 liters of fluid every 24hours, the kidney also regulates acid-base balance, maintains electrolyte balance, and removes waste and toxicants from the body. Nephrotoxicity is the term used to describe the deterioration of kidney function caused by the harmful effects of medications and chemicals found in the environment. Exposure to environmental toxicants is an inevitable side effect of the world's increasing industrialization and it is even more prevalent in underdeveloped nations...
March 20, 2024: Toxicology
https://read.qxmd.com/read/38518818/molecular-insights-into-the-catabolism-of-dibutyl-phthalate-in-pseudomonas-aeruginosa-ps1-based-on-biochemical-and-multi-omics-approaches
#26
JOURNAL ARTICLE
Huan Du, Ji-Liang Cheng, Zhi-Yong Li, Huai-Ning Zhong, Shuang Wei, Yu-Juan Gu, Can-Can Yao, Miaoyue Zhang, Quan-Ying Cai, Hai-Ming Zhao, Ce-Hui Mo
A comprehensive understanding of the molecular mechanisms underlying microbial catabolism of dibutyl phthalate (DBP) is still lacking. Here, we newly isolated a bacterial strain identified as Pseudomonas aeruginosa PS1 with high efficiency of DBP degradation. The degradation ratios of DBP at 100-1000 mg/L by this strain reached 80-99 % within 72 h without a lag phase. A rare DBP-degradation pathway containing two monobutyl phthalate-catabolism steps was proposed based on intermediates identified by HPLC-TOF-MS/MS...
March 20, 2024: Science of the Total Environment
https://read.qxmd.com/read/38513954/mitigating-phthalate-toxicity-the-protective-role-of-humic-acid-and-clay-in-zebrafish-larvae
#27
JOURNAL ARTICLE
Abdulkhalik Mansuri, Charvi Trivedi, Aashi Parikh, Ashutosh Kumar
This research study aimed to explore the mitigating effects of humic acid and clay on the toxicity induced by three different phthalates (DBP, DEP, DEHP) on zebrafish larvae growth. Prolonged exposure to DBP resulted in a concerning 87.33% mortality rate, significantly reduced to 7.3% when co-administered with humic acid. A similar reduction in mortality was observed for the other two phthalates (DEP and DEHP). Additionally, the introduction of phthalates with humic acid, clay, or their combination led to a significant decrease in the malformation rate in larvae...
March 19, 2024: Chemosphere
https://read.qxmd.com/read/38513944/revealing-chemical-release-from-plastic-debris-in-animals-digestive-systems-using-nontarget-and-suspect-screening-and-simulating-digestive-fluids
#28
JOURNAL ARTICLE
Xianzhi Peng, Tao Yang, Shang Guo, Jing Zhou, Guangshi Chen, Zewen Zhu, Jianhua Tan
Plastic debris in the environment are not only pollutants but may also be important sources of a variety of contaminants. This work simulated kinetics and potential of chemical leaching from plastic debris in animals' digestive systems by incubating polyvinyl chloride (PVC) cord particles in artificial digestive fluids combined with nontarget and suspect screening based on UHPLC-Orbitrap HRMS. Impacts of particle size, aging, and digestive fluid were investigated to elucidate mechanisms of chemical leaching...
March 19, 2024: Environmental Pollution
https://read.qxmd.com/read/38513858/di-2-ethylhexyl-phthalate-and-polystyrene-microplastics-co-exposure-caused-oxidative-stress-to-activate-nf-%C3%AE%C2%BAb-nlrp3-pathway-aggravated-pyroptosis-and-inflammation-in-mouse-kidney
#29
JOURNAL ARTICLE
Shanshan Li, Xuedie Gu, Muyue Zhang, Qihang Jiang, Tong Xu
Polystyrene microplastic (PS-MPs) contamination has become a worldwide hotspot of concern, and its entry into organisms can cause oxidative stress resulting in multi-organ damage. The plasticizer di (2-ethylhexyl) phthalate (DEHP) is a common endocrine disruptor, these two environmental toxins often occur together, but their combined toxicity to the kidney and its mechanism of toxicity are unknown. Therefore, in this study, we established PS-MPS and/or DEHP-exposed mouse models. The results showed that alone exposure to both PS-MPs and DEHP caused inflammatory cell infiltration, cell membrane rupture, and content spillage in kidney tissues...
March 19, 2024: Science of the Total Environment
https://read.qxmd.com/read/38513557/analyzing-the-impact-of-phthalate-and-dinch-exposure-on-fetal-growth-in-a-cohort-with-repeated-urine-collection
#30
JOURNAL ARTICLE
Marion Ouidir, Paulina Jedynak, Matthieu Rolland, Sarah Lyon-Caen, Cathrine Thomsen, Amrit K Sakhi, Azemira Sabaredzovic, Sam Bayat, Rémy Slama, Claire Philippat
BACKGROUND: Most previous studies investigating the associations between prenatal exposure to phthalates and fetal growth relied on measurements of phthalate metabolites at a single time point. They also focused on weight at birth without assessing growth over pregnancy, preventing the identification of potential periods of fetal vulnerability. We examined the associations between pregnancy urinary phthalate metabolites and fetal growth outcomes measured twice during pregnancy and at birth...
March 16, 2024: Environment International
https://read.qxmd.com/read/38508420/the-mitochondrial-link-phthalate-exposure-and-cardiovascular-disease
#31
REVIEW
Shama Prasada Kabekkodu, Lauren Rae Gladwell, Mahua Choudhury
Phthalates' pervasive presence in everyday life poses concern as they have been revealed to induce perturbing health defects. Utilized as a plasticizer, phthalates are riddled throughout many common consumer products including personal care products, food packaging, home furnishings, and medical supplies. Phthalates permeate into the environment by leaching out of these products which can subsequently be taken up by the human body. It is previously established that a connection exists between phthalate exposure and cardiovascular disease (CVD) development; however, the specific mitochondrial link in this scenario has not yet been described...
March 18, 2024: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/38508268/exposure-to-di-2-ethylhexyl-phthalate-and-breast-neoplasm-incidence-a-cohort-study
#32
JOURNAL ARTICLE
Lijuan Tang, Yimeng Wang, Wenting Yan, Zhe Zhang, Siwen Luo, Qiaorui Wen, Shengfeng Wang, Niya Zhou, Qing Chen, Yan Xu
BACKGROUND: Phthalates are ubiquitous environmental endocrine disruptors. As the predominant phthalate, di-2-ethylhexyl phthalate (DEHP) has been considered possibly carcinogenic to humans but large-scale longitudinal evidence is needed to further clarify its carcinogenicity. OBJECTIVES: To examine the association between DEHP exposure and incidence of breast malignant neoplasm, carcinoma in situ and benign neoplasm. METHODS: A total of 273,295 women from UK Biobank cohort were followed up for a median of 13...
March 18, 2024: Science of the Total Environment
https://read.qxmd.com/read/38507935/translational-toxicoepigenetic-meta-analyses-identify-homologous-gene-dna-methylation-reprogramming-following-developmental-phthalate-and-lead-exposure-in-mouse-and-human-offspring
#33
JOURNAL ARTICLE
Rebekah L Petroff, Dana C Dolinoy, Kai Wang, Luke Montrose, Vasantha Padmanabhan, Karen E Peterson, Douglas M Ruden, Maureen A Sartor, Laurie K Svoboda, Martha M Téllez-Rojo, Jaclyn M Goodrich
Although toxicology uses animal models to represent real-world human health scenarios, a critical translational gap between laboratory-based studies and epidemiology remains. In this study, we aimed to understand the toxicoepigenetic effects on DNA methylation after developmental exposure to two common toxicants, the phthalate di(2-ethylhexyl) phthalate (DEHP) and the metal lead (Pb), using a translational paradigm that selected candidate genes from a mouse study and assessed them in four human birth cohorts...
March 11, 2024: Environment International
https://read.qxmd.com/read/38507928/a-generalizable-sensing-platform-based-on-molecularly-imprinted-polymer-aptamer-double-recognition-and-nanoenzyme-assisted-photoelectrochemical-colorimetric-dual-mode-detection
#34
JOURNAL ARTICLE
Ying-Zhuo Shen, Wen Zheng Xie, Zheng Wang, Kang Ping Ning, Zheng Ping Ji, Hong Bo Li, Xiao-Ya Hu, Cheng Ma, Xu Qin
Developing highly sensitive and selective methods that incorporate specific recognition elements is crucial for detecting small molecules because of the limited availability of small molecule antibodies and the challenges in obtaining sensitive signals. In this study, a generalizable photoelectrochemical-colorimetric dual-mode sensing platform was constructed based on the synergistic effects of a molecularly imprinted polymer (MIP)-aptamer sandwich structure and nanoenzymes. The MIP functionalized peroxidase-like Fe3 O4 (Fe3 O4 @MIPs) and alkaline phosphatase mimic Zr-MOF labeled aptamer (Zr-mof@Apt) were used as the recognition elements...
March 11, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38503108/dibutyl-phthalate-dbp-promotes-epithelial-mesenchymal-transition-emt-to-aggravate-liver-fibrosis-into-cirrhosis-and-portal-hypertension-pht-via-ros-tgf-%C3%AE-1-snail-1-signalling-pathway-in-adult-rats
#35
JOURNAL ARTICLE
Min Chen, Guang-Bo Wu, Shan Hua, Lei Zheng, Qiang Fan, Meng Luo
OBJECTIVE: The primary objective of this study was to investigate the toxicological impact of Dibutyl phthalate (DBP) on the process of liver fibrosis transitioning into cirrhosis and the subsequent development of portal hypertension (PHT) through the mechanism of epithelial-mesenchymal transition (EMT) mediated by the ROS/TGF-β/Snail-1 signaling pathway. METHOD: Carbon tetrachloride (CCl4 ) (1 mg/kg) was introduced in adult rats by oral feeding in CCl4 and CCl4 +DBP groups twice a week for 8 weeks, and twice for another 8 week in CCl4 group...
March 18, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38503103/association-of-phthalate-exposure-with-type-2-diabetes-and-the-mediating-effect-of-oxidative-stress-a-case-control-and-computational-toxicology-study
#36
JOURNAL ARTICLE
Yuxuan Tan, Ziang Guo, Huojie Yao, Han Liu, Yingyin Fu, Yangxu Luo, Rong He, Yiwan Liu, Pei Li, Lihong Nie, Lei Tan, Chunxia Jing
Phthalic acid esters (PAEs) are widely used as plasticizers and have been suggested to engender adverse effects on glucose metabolism. However, epidemiological data regarding the PAE mixture on type 2 diabetes (T2DM), as well as the mediating role of oxidative stress are scarce. This case-control study enrolled 206 T2DM cases and 206 matched controls in Guangdong Province, southern China. The concentrations of eleven phthalate metabolites (mPAEs) and the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine were determined...
March 18, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38501660/metabolic-mechanism-and-pharmacological-study-of-albendazole-in-secondary-hepatic-alveolar-echinococcosis-hae-model-rats
#37
JOURNAL ARTICLE
Chaoqun Li, Yaogang Zhang, Mingquan Pang, Yong Zhang, Chunhui Hu, Haining Fan
Albendazole (ABZ) is the primary treatment for alveolar echinococcosis (AE); however, its limited solubility impacts oral bioavailability, affecting therapeutic outcomes. In this study, various ABZ-solubilizing formulations, including albendazole crystal dispersion system (ABZ-CSD), albendazole hydrochloride-hydroxypropyl methylcellulose phthalate composite (TABZ-HCl-H ), and albendazole hydroxyethyl sulfonate-hydroxypropyl methylcellulose phthalate composite (TABZ-HES-H ), were developed and evaluated. Physicochemical properties as well as liver enzyme activity were analyzed and their pharmacodynamics in an anti-secondary hepatic alveolar echinococcosis (HAE) rat model were investigated...
March 19, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38499958/di-2-ethylhexyl-phthalate-exposure-induces-premature-testicular-senescence-by-disrupting-mitochondrial-respiratory-chain-through-stat5b-mitostat3-in-leydig-cell
#38
JOURNAL ARTICLE
Haiming Cao, Qigen Xie, Peng Luo, Jiaqi Chen, Kai Xia, Lin Ma, Demeng Chen, Chunhua Deng, Zi Wan
Di-(2-ethylhexyl) phthalate (DEHP), a prevalent plasticizer, is known to have endocrine-disrupting effects on males and cause reproductive toxicity. There were causal effects of DEHP on testosterone levels in the real world by Mendelian randomization analysis. Exposure to DEHP during the preadult stage might lead to premature testicular senescence, but the mechanisms responsible for this have yet to be determined. In this study, we administered DEHP (300 mg/kg/day) to male C57BL/6 mice from postnatal days 21 to 49...
March 19, 2024: GeroScience
https://read.qxmd.com/read/38499263/is-photoelectrocatalysis-an-efficient-process-to-degrade-endocrine-disruptors-chemicals
#39
JOURNAL ARTICLE
M Cifre-Herrando, G Roselló-Márquez, J García-Antón
Endocrine disruptors chemicals (EDCs) pose significant health risks, including cancer, behavioral disorders, and infertility. In this study, we employed the photoelectrocatalysis (PEC) technique with optimized tungsten oxide (WO3 ) nanostructures as a photoanode to degrade three diverse EDCs: methiocarb, dimethyl phthalate, and 4-tert-butylphenol. PEC degradation tests were carried out for individual contaminants and a mixture of them, assessing efficiency across different EDC families. Ultra High-Performance Liquid Chromatography and Mass Spectrometry was used to control the course of the experiments...
March 16, 2024: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/38498134/migration-and-distribution-characteristics-of-typical-organic-pollutants-in-condensable-particulate-matter-of-coal-fired-flue-gas-and-by-products-of-wet-flue-gas-desulfurization-system
#40
JOURNAL ARTICLE
Zhenyao Xu, Yujia Wu, Siqi Liu, Minghui Tang, Shengyong Lu
The wet flue gas desulfurization (WFGD) system of coal-fired power plants shows a good removal effect on condensable particulate matter (CPM), reducing the dust removal pressure for the downstream flue gas purification devices. In this work, the removal effect of a WFGD system on CPM and its organic pollutants from a coal-fired power plant was studied. By analyzing the organic components of the by-products emitted from the desulfurization tower, the migration characteristics of organic pollutants in gas, liquid, and solid phases, as well as the impact of desulfurization towers on organic pollutants in CPM, were discussed...
March 18, 2024: Environmental Science and Pollution Research International
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