Read by QxMD icon Read


Sarva Mangala Praveena, Seoh Wei Teh, Ranjith Kumar Rajendran, Narayanan Kannan, Chu-Ching Lin, Rozaini Abdullah, Suresh Kumar
Phthalates have been blended in various compositions as plasticizers worldwide for a variety of purposes. Consequently, humans are exposed to a wide spectrum of phthalates that needs to be researched and understood correctly. The goal of this review is to focus on phthalate's internal exposure pathways and possible role of human digestion on liver toxicity. In addition, special focus was made on stem cell therapy in reverting liver toxicity. The known entry of higher molecular weight phthalates is through ingestion while inhalation and dermal pathways are for lower molecular weight phthalates...
March 15, 2018: Environmental Science and Pollution Research International
Jianping Cao, Xu Zhang, Yinping Zhang
Dermal exposure to indoor gas-phase semi-volatile organic compounds (SVOCs) has recently received a great deal of attention, and this has included evaluating the role of clothing in this process. Several models have been developed to assess dermal exposure to SVOCs, based on the transient mass transfer of SVOCs from air to dermal capillaries. However, these models assume either that clothing completely retards SVOC transport, or that there is an air gap of constant thickness between the clothing and the surface of the skin, leading to significant errors in the model calculations...
March 15, 2018: Environmental Science & Technology
Noushin Rastkari, Maryam Zare Jeddi, Masud Yunesian, Reza Ahmadkhaniha
Acidic liquids such as verjuice, lemon juice and vinegar are frequently consumed in Iran. Different kinds of acidic liquids are packaged in polyethylene terephthalate (PET) and high-density polyethylene (HDPE) bottles. There is evidence indicating that phthalates can leach from PET and HDPE bottles into their contents. In this work the effect of storage time, temperature and bottle type on the migration of phthalates from packaging materials into acidic liquids is studied by analyzing the samples stored under different conditions, before storage and after 2, 4 and 6 months of storage...
December 2017: Food Technology and Biotechnology
Ting Deng, Yu Zhang, Yang Wu, Ping Ma, Jiufei Duan, Wei Qin, Xu Yang, Mingqing Chen
Epidemiological studies suggest a positive relationship between phthalate exposure and diabetes. However, little is known about the impact of dibutyl phthalate (DBP) exposure on the development of diabetes. To determine the role of DBP exposure on the development of type 2 diabetes, mice were orally exposed to DBP dosages of 0.5, 5, 50 mg/kg/day for 7 weeks, combined with a high fat diet and injections of a low dose of streptozotocin (STZ). The results showed that exposure to 50 mg/kg/day DBP alone induced a marked decrease in insulin secretion and glucose intolerance, but had no influence on insulin resistance...
March 8, 2018: Toxicology Letters
Guang-Wen Lien, Jung-Hsuan Chen, Fang-Wei Tien, Pau-Chung Chen, Huei-Wen Chen, Hsaio-Lin Hwa, Cheng-Chung Fang, Te-I Weng, Pai-Shan Chen
Phthalates are not covalently bound to plastics. They can leach from experimental plastic devices. Due to the development of sensitive techniques, exogenous sources that interfere with the accuracy of phthalate monoester analysis can be easily detected. Here, we propose the simple and rapid dilute-and-shoot method to minimize sample handling and limit contact with laboratory apparatus, which efficiently reduced phthalate interferences mainly from experimental plasticware and improved the accuracy of analysis...
March 3, 2018: Journal of Hazardous Materials
Javier González-Sálamo, Miguel Ángel González-Curbelo, Bárbara Socas-Rodríguez, Javier Hernández-Borges, Miguel Ángel Rodríguez-Delgado
A new hollow fiber liquid-phase microextraction (HF-LPME) method has been developed for the extraction of a group of phthalic acid esters (PAEs) of interest from different water samples prior to gas chromatography tandem mass spectrometry analysis. HF-LPME was carried out using 1-octanol as extraction solvent followed by a back extraction step with cyclohexane. The different parameters that affect HF-LPME such as sample pH, ionic strength, extraction time, stirring rate, extraction temperature and back extraction conditions were investigated...
March 1, 2018: Chemosphere
Bárbara Socas-Rodríguez, Javier González-Sálamo, Antonio V Herrera-Herrera, Álvaro Santana-Mayor, Javier Hernández-Borges
In this work, a new method has been developed for the determination of 14 phthalic acid esters (i.e., benzylbutyl phthalate (BBP), bis-2-n-butoxyethyl phthalate (DBEP), dibutyl phthalate (DBP), dicyclohexyl phthalate (DCHP), bis-2-ethoxyethyl phthalate (DEEP), diethyl phthalate (DEP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), bis-isopentyl phthalate (DIPP), bis (2-methoxyethyl) phthalate (DMEP), dimethyl phthalate (DMP), di-n-octyl phthalate (DNOP), bis-n-pentyl phthalate (DNPP), dipropyl phthalate (DPP)) and one adipate (bis (2-ethylhexyl) adipate (DEHA)) in different baby foods...
March 9, 2018: Analytical and Bioanalytical Chemistry
L Montrose, V Padmanabhan, J M Goodrich, S E Domino, M C Treadwell, J D Meeker, D J Watkins, D C Dolinoy
Endocrine disrupting chemicals (EDCs) pose a public health risk through disruption of normal biological processes. Identifying toxicoepigenetic mechanisms of developmental exposure-induced effects for EDCs, such as phthalates or bisphenol A (BPA), is essential. Here, we investigate whether maternal exposure to EDCs is predictive of infant DNA methylation at candidate gene regions. In the Michigan Mother-Infant Pairs (MMIP) cohort, DNA was extracted from cord blood leukocytes for methylation analysis by pyrosequencing (n = 116) and methylation changes related to first trimester levels of 9 phthalate metabolites and BPA...
March 7, 2018: Epigenetics: Official Journal of the DNA Methylation Society
Katherine S Carlos, Lowri S deJager, Timothy H Begley
PVC is a common food contact material that is usually plasticized to increase its flexibility. Phthalates are one class of chemical compounds that are often used as plasticizers in PVC in a wide range of industries. They may be used in packaging materials for foods and can also be found in components of certain food processing equipment such as conveyor belts and tubing. Transfer of plasticizers from packaging to foods can occur. In recent years, there has been increased interest in understanding the health effects of phthalates, as well as the possible human exposure levels...
March 6, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Uros Midic, Benjamin Goheen, Kailey A Vincent, Catherine A VandeVoort, Keith E Latham
Trophoblast stem cells (TSCs) are crucial for embryo implantation and placentation. Environmental toxicants that compromise TSC function could impact fetal viability, pregnancy, and progeny health. Understanding the effects of low, chronic EDC exposures on TSCs and pregnancy is a priority in developmental toxicology. Differences in early implantation between primates and other mammals make a nonhuman primate model ideal. We examined effects of chronic low-level exposure to atrazine, tributyltin, bisphenol A, bis(2-ethylhexyl) phthalate, and perfluorooctanoic acid on rhesus monkey TSCs in vitro by RNA sequencing...
March 2, 2018: Reproductive Toxicology
Annemarie Stroustrup, Jennifer B Bragg, Syam S Andra, Paul C Curtin, Emily A Spear, Denise B Sison, Allan C Just, Manish Arora, Chris Gennings
Every year in the United States, more than 300,000 infants are admitted to neonatal intensive care units (NICU) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. The neurodevelopmental impact of environmental exposure to phthalates during the NICU stay is unknown. As phthalate exposure during the third trimester developmental window has been implicated in neurobehavioral deficits in term-born children that are strikingly similar to a phenotype of neurobehavioral morbidity common among children born premature, the role of early-life phthalate exposure on the neurodevelopmental trajectory of premature infants may be clinically important...
2018: PloS One
Muhammad Rouf Akram, Mahmood Ahmad, Asad Abrar, Rai Muhammad Sarfraz, Asif Mahmood
Background: The present work was conducted to prepare and evaluate transdermal patches with optimization of suitable polymeric blend of poly(meth) acrylates (Eudragit® ) (Ammonio Methacrylate Copolymer Ph Eur) for sustained transdermal delivery of glimepiride. Method: Polymeric matrix transdermal films were prepared by using Ammonio Methacrylate Copolymer Ph Eur RL 100 and Ammonio Methacrylate Copolymer Ph Eur RS 100 as the film former, and dibutyl phthalate (30% w/w) as the plasticizer...
2018: Drug Design, Development and Therapy
L Rubio, L A Sarabia, M C Ortiz
This paper presents the simultaneous determination of a UV stabilizer (benzophenone (BP)) together with four plasticizers (butylated hydroxytoluene (BHT), diisobutyl phthalate (DiBP), bis(2-ethylhexyl) adipate (DEHA) and diisononyl phthalate (DiNP)) in Tenax by gas chromatography/mass spectrometry and PARAFAC, using DiBP-d4 as internal standard. Regulation (EU) No. 10/2011 establishes Tenax as food simulant E for testing specific migration from plastics into dry foodstuffs. This simulant must be cleaned before its use to eliminate impurities...
May 15, 2018: Talanta
Mahin Hashemipour, Roya Kelishadi, Mohammad Mehdi Amin, Karim Ebrahim
Considerable increase in the prevalence of precocious puberty (PP) during the last decade has raised a lot of concerns. Some environmental endocrine disruptor chemicals (EDCs), such as phthalate esters, have intrinsic estrogen activity or increase endogenous sex hormone levels leading to PP. This study was conducted to investigate the association between exposure to phthalate esters and PP in a sample of girls. Plasma levels of seven phthalate ester metabolites were measured in 87 girls with PP and 63 age- and sex-matched controls by dispersive liquid-liquid microextraction and GC/MS analysis...
March 1, 2018: Environmental Science and Pollution Research International
Yongfeng Xu, Shixiang Dai, Ke Meng, Yuting Wang, Wenjie Ren, Ling Zhao, Peter Christie, Ying Teng
The residual levels and risk assessment of several potentially toxic elements (PTEs), phthalate esters (PAEs) and polycyclic aromatic hydrocarbons (PAHs) in rural soils near different types of pollution sources in Tianjin, China, were studied. The soils were found to be polluted to different extents with PTEs, PAEs and PAHs from different pollution sources. The soil concentrations of chromium (Cr), nickel (Ni), di-n-butyl phthalate (DnBP), acenaphthylene (Any) and acenaphthene (Ane) were higher than their corresponding regulatory reference limits...
February 26, 2018: Science of the Total Environment
Norma I Torres, Xue Yu, Ingrid Y Padilla, Raul E Macchiavelli, Reza Ghasemizadeh, David Kaeli, Jose F Cordero, John D Meeker, Akram N Alshawabkeh
This study investigates the occurrence of six phthalates and distribution of the three most-detected phthalates in the karst region of northern Puerto Rico (KRNPR) using data from historical records and current field measurements. Statistical data analyses, including ANOVA, Chi-Square, and logistic regression models are used to examine the major factors affecting the presence and concentrations of phthalates in the KRNPR. The most detected phthalates include DEHP, DBP, and DEP. At least one phthalate specie is detected above DL in 7% of the samples and 24% of the sampling sites...
February 26, 2018: Environmental Pollution
Muhammad Furqan Akhtar, Muhammad Ashraf, Aqeel Javeed, Aftab Ahmad Anjum, Ali Sharif, Mohammad Saleem, Ghulam Mustafa, Moneeb Ashraf, Ammara Saleem, Bushra Akhtar
Complex industrial discharges pose certain risks to the ecosystem. This study was aimed at identifying acute and sub-chronic toxicological effects of the textile industry wastewater. The textile wastewater was evaluated for the metals and organic pollutants by atomic absorption spectrophotometer and GC-MS respectively. In vitro genotoxicity and mutagenicity were assessed by Comet assay in peripheral lymphocytes isolated from Ovis aries and Ames test in Salmonella typhimurium strains TA-100 and 102 respectively...
February 28, 2018: Environmental Monitoring and Assessment
Paula Valenzuela-Leon, Ina Dobrinski
Phthalate esters are plasticizers that impart flexibility to polvinylchloride plastics. As they are not covalently bound, they can leach from a wide range of products, including food containers, medical devices, clothing, and toys, leading to widespread environmental exposure. Phthalate toxicity has been linked to male infertility by disrupting testosterone production and testis development. Phthalates also impair proliferation and viability of spermatogonial stem cells (SSC), the role of which is to support lifelong spermatogenesis...
July 2017: Environmental Epigenetics
Ming-Jing He, Jun-Feng Lu, Jing-Ye Ma, Huan Wang, Xiao-Fan Du
Human hair and street dust from rural and urban areas in Chongqing were collected to analyze Organophosphate esters (OPEs) and phthalate esters (PAEs). Concentrations of OPEs in urban hair were significantly higher than those in rural hair, whereas PAEs concentrations in rural hair were significantly higher than those in urban hair. Different composition patterns of OPEs were observed in rural and urban hair, where tris (2-chloroisopropyl) phosphate (TCIPP), tris (butyl) phosphate (TNBP) and triphenyl phosphate (TPHP) were the dominating analogues in rural hair, accounting for 62...
February 23, 2018: Environmental Pollution
Dario Savoca, Marco Arculeo, Salvatore Barreca, Silvestre Buscemi, Santo Caracappa, Antonino Gentile, Maria Flaminia Persichetti, Andrea Pace
Tissues from thirteen specimens of marine turtles, one Dermochelys coriacea and twelve Caretta caretta, found dead along the Sicilian coasts in 2016 were analyzed for the presence of phthalates. Four phthalates (DEP, DBP, BBP, and DEHP) were found at different significant concentrations in liver and gonads, while only DBP was found in muscle tissues and at a fourfold lower concentration than other phthalates in Dermochelys coriacea. No traces of DEP were detected in C. caretta tissues where DOTP was also revealed...
February 2018: Marine Pollution Bulletin
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"