Read by QxMD icon Read


Angela L Perez, Monty Liong, Kevin Plotkin, Keith P Rickabaugh, Dennis J Paustenbach
This study provides an exposure and risk assessment of diundecyl phthalate (DUP), a high molecular weight phthalate plasticizer present in automobile interiors. Total daily intake of DUP was calculated from DUP measured in wipe samples from vehicle seats from six automobiles. Four of the vehicles exhibited atypical visible surface residue on the seats. Two vehicles with no visible surface residue were sampled as a comparison. DUP was the predominant organic compound identified in each of the wipes from all seats...
October 18, 2016: Chemosphere
Yan G Fulcher, Martial Fotso, Chee-Hoon Chang, Hans Rindt, Carol R Reinero, Steven R Van Doren
Asthma is prevalent in children and cats, and needs means of noninvasive diagnosis. We sought to distinguish noninvasively the differences in 53 cats before and soon after induction of allergic asthma, using NMR spectra of exhaled breath condensate (EBC). Statistical pattern recognition was improved considerably by preprocessing the spectra with probabilistic quotient normalization and glog transformation. Classification of the 106 preprocessed spectra by principal component analysis and partial least squares with discriminant analysis (PLS-DA) appears to be impaired by variances unrelated to eosinophilic asthma...
2016: PloS One
Andreia Alves, Gudrun Koppen, Guido Vanermen, Adrian Covaci, Stefan Voorspoels
Phthalate esters (PEs) are easily metabolized and commonly excreted via urine within 24h, therefore their bioaccumulation potential is thought to be rather low. In the present study, we developed a sample preparation combined with a new microextraction method to measure seven PE metabolites in nails. The use of whole nails did not result in significantly different levels compared to powdered nails, which makes the method very fast and user friendly. The method was validated using whole nails showing good accuracy, satisfactory precision and low limits of quantification (2-14ng/g)...
September 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Haitham Alrabiah, Abdulrahman Al-Majed, Mohammed Abounassif, Gamal A E Mostafa
The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (-59.1 and -62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5...
December 1, 2016: Acta Pharmaceutica
Zhiyong Bai, Qi Yang, Jianlong Wang
In this paper, Fe3O4/multi-wall carbon nanotubes composites were prepared, characterized and used as a catalyst for enhancing the ozonation of dimethyl phthalate (DMP) in aqueous solution. The experimental results showed that DMP degradation and mineralization increased by 26% and 20%, respectively, in catalytic ozonation compared with single ozonation, and more H2O2 and organic acids were produced during catalytic ozonation process than single ozonation. The effect of pH, ozone concentration and catalyst dosage on DMP degradation was determined...
October 17, 2016: Environmental Technology
Brett T Doherty, Stephanie M Engel, Jessie P Buckley, Manori J Silva, Antonia M Calafat, Mary S Wolff
INTRODUCTION: Evidence suggests prenatal phthalate exposures may have neurodevelopmental consequences. Our objective was to investigate prenatal exposure to phthalates and cognitive development in a cohort of young urban children. MATERIALS AND METHODS: We recruited pregnant women in New York City from 1998 to 2002 and measured concentrations of nine phthalate metabolites in urine collected in late pregnancy. We administered a neurodevelopmental screening instrument, the Bayley Scales of Infant Development II (BSID-II), to children who returned for follow-up at approximately 24 months (n=276)...
October 11, 2016: Environmental Research
Jianteng Sun, Lili Pan, Daniel C W Tsang, Zhiheng Li, Lizhong Zhu, Xiangdong Li
The present study investigated phthalate esters (PAEs) and organochlorine pesticides (OCPs) in agricultural soils and vegetables from eastern China. The concentrations of PAEs ranged from 109 to 5560 ng/g in soils and 60.1 to 2390 ng/g in cabbages, with average concentrations of 946 and 601 ng/g, respectively. The concentrations of OCPs ranged from <0.1 to 662 ng/g in soils and <0.1 to 42.8 ng/g in cabbages, with average concentrations of 134 and 11.6 ng/g, respectively. OCPs were mainly in the 0-30 cm surface soil layers, while PAEs could infiltrate in deep soil profiles to 70-80 cm layer...
October 13, 2016: Environmental Science and Pollution Research International
Nai-Yun Hsu, Yu-Chun Liu, Chia-Wei Lee, Ching-Chang Lee, Huey-Jen Su
Water damage and moisture in buildings may become more prevalent due to the increasing frequency of extreme precipitation and flooding events resulting from climate change. However, the effects of moisture levels on phthalate emissions from building materials are still underreported. This study aims to evaluate the effect of moisture content (MC) on the level of di-(2ethylhexyl) phthalate (DEHP) emitted from plastic wallpaper (0.22wt% DEHP) within 15 days in a closed chamber. A scenario of short-term exposure to DEHP in buildings suffering from water damage was simulated...
October 10, 2016: Environmental Research
Tao Zhang, Zehua Huang, Xiaohong Chen, Mingzhi Huang, Jujun Ruan
Dimethyl phthalate (DMP) as one of the most important and extensively used Phthalic acid esters (PAEs) is known to likely cause dysfunctions of the endocrine systems, liver, and nervous systems of animals. In this paper, the degradation and behavior of DMP were investigated in a laboratory scale anaerobic/anoxic/oxic (AAO) treatment system. In addition, a degradation model including biodegradation and sorption was formulated so as to evaluate the fate of DMP in the treatment system, and a mass balance model was designed to determine kinetic parameters of the removal model...
October 8, 2016: Journal of Environmental Management
Takeo Kubota
Epigenetics is an important mechanism of gene regulation that is dependent on the chromatin structure, which is determined by the epigenetic chemical modification of DNA and histone proteins. It is known that the failure of epigenetic mechanisms causes congenital neurodevelopmental disorders (NDs), and that early life exposure to mental stress and endocrine disrupting chemicals, such as phthalates, bisphenol A, and tobacco, can change epigenetic mechanism and gene expression in the brain and cause NDs. Moreover, environmentally induced epigenetic changes are not erased during gametogenesis and are transmitted to subsequent generations, leading to changes in behavior phenotypes...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Kyoko Wada, Barbra de Vrijer, Barbara F Hales, Jeff Nisker
BACKGROUND: There have long been minimal risk thresholds beneath which risks may not need to be discussed in clinical research. This threshold concept may be applied to clinical practice. Our research explored application of minimal risk standards in research regulations to providing information in prenatal and pre-conception care. METHODS: A case study approach applied minimal risk standards in research regulations to prenatal and pre-conception care with respect to the risks of excess alcohol consumption, folic acid insufficiency, exposure to phthalate plasticizers, and exposure to brominated flame retardants (BFRs)...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Ishfaq A Sheikh, Muhammad Yasir, Muhammad Abu-Elmagd, Tanveer A Dar, Adel M Abuzenadah, Ghazi A Damanhouri, Mohammed Al-Qahtani, Mohd A Beg
BACKGROUND: Currently, alternate plasticizers are used to replace phthalate plasticizers in children's toys, medical equipments and food packaging, due to the adverse effects of phthalate compounds on human health and laws prohibiting their use. Current information regarding the safety and potential adverse effects of alternate plasticizers is limited and recent studies have found alternate plasticizers to display similar characteristics to those observed in phthalate plasticizers. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly used alternate plasticizers: di(2-ethylhexyl)terephthalate (DEHT), tris(2-ethylhexyl)trimellitate (TOTM), and diisononyl hexahydrophthalate (DINCH) against human sex hormone-binding globulin (SHBG) using in silico approaches...
September 30, 2016: BMC Structural Biology
Ishfaq A Sheikh, Muhammad Abu-Elmagd, Rola F Turki, Ghazi A Damanhouri, Mohd A Beg, Mohammed Al-Qahtani
BACKGROUND: Di-(2-ethylhexyl)phthalate (DEHP) is a common endocrine disrupting compound (EDC) present in the environment as a result of industrial activity and leaching from polyvinyl products. DEHP is used as a plasticizer in medical devices and many commercial and household items. Exposure occurs through inhalation, ingestion, and skin contact. DEHP is metabolized to a primary metabolite mono-(2-ethylhexyl)phthalate (MEHP) in the body, which is further metabolized to four major secondary metabolites, mono(2-ethyl-5-hydroxyhexyl)phthalate (5-OH-MEHP), mono(2-ethyl-5-oxyhexyl)phthalate (5-oxo-MEHP), mono(2-ethyl-5-carboxypentyl)phthalate (5-cx-MEPP) and mono[2-(carboxymethyl)hexyl]phthalate (2-cx-MMHP)...
September 30, 2016: BMC Structural Biology
Ji-Feng Yang, Li-Ming Yang, Li-Ying Zheng, Guang-Guo Ying, Cheng-Bin Liu, Sheng-Lian Luo
Concentrations of six phthalates were determined in 69 plastic bottled non-alcoholic beverages collected from marketplaces in China. Di-n-butyl phthalate (DBP) and Di- (2-ethylhexyl)-phthalate (DEHP) were the most detected compounds with frequencies of 100%. Dimethyl phthalate (DMP) was found less, with a mean frequency of almost 34%. The samples were divided in 7 groups. The frequencies of phthalates in these groups ranged from 6.67 to 100%, which indicated that different types of beverages were differently contaminated by phthalates...
October 9, 2016: Food Additives & Contaminants. Part B, Surveillance
Yufeng Miao, Runhuai Wang, Chan Lu, Jinping Zhao, Qihong Deng
The plasticizer di(2-ethylhexyl) phthalate (DEHP) is ubiquitous in the environment and considered as carcinogen; however, the carcinogenic risk of human exposure to DEHP in the air via inhalation is lacking. A probabilistic incremental lifetime cancer risk (ILCR) model was implemented to quantitatively estimate the potential cancer risk of DEHP via human inhalation by using Monte Carlo simulation. We assessed the cancer risk in different age groups (children, adolescents, and adults) exposed to different DEHP concentrations (background low, indoor moderate, and occupational high) for different durations (2, 8, and 20 years)...
October 7, 2016: Environmental Science and Pollution Research International
Gita Saini, Shalini Pant, Shri Om Singh, A A Kazmi, Tanveer Alam
Phthalates are endocrine-disrupting chemicals which affect endocrine system by bio-accumulation in aquatic organisms and produce adverse health effects in aquatic organisms as well as human beings, when come in contact. Present study focuses on occurrence and removal of two phthalates: diethylphthalate (DEP) and dibutylphthalate (DBP) in two full-scale wastewater treatment plants (WWTPs) i.e. sewage treatment plants (STPs) based on well-adopted technologies, activated sludge process (ASP) and sequencing batch reactor (SBR)...
November 2016: Environmental Monitoring and Assessment
Marisa Morgan, Alok Deoraj, Quentin Felty, Deodutta Roy
BACKGROUND: Estrogen-mimicking endocrine disruptors (EEDs) such as polychlorinated biphenyls (PCBs), bisphenol A (BPA), and phthalates have been found ubiquitously throughout our environment. Although exposure to EEDs has the ability to interfere with endocrine control of reproductive function and development in both humans and wildlife, inconsistent reports have made it difficult to draw conclusions concerning the hypothesized increased risk of breast cancer associated with EEDs. OBJECTIVES: The purpose of this study was to examine the cross-sectional relationship between exposure to PCBs, BPA or phthalates; and risk of breast cancer in U...
October 4, 2016: Molecular and Cellular Endocrinology
Yong Jun Choi, Kyoung Hwa Ha, Dae Jung Kim
It was recently discovered that bisphenol A (BPA) and phthalates are cardiovascular disruptors. Inflammation is central to the initiation and progression of cardiovascular disease (CVD). This study evaluated whether BPA and different phthalate metabolites are associated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in healthy Korean adults. This research is part of an ongoing, population-based study of Korean adults (30-64 years of age) conducted at the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC)...
October 6, 2016: Environmental Science and Pollution Research International
Maryam Zarean, Mojtaba Keikha, Parinaz Poursafa, Pooyan Khalighinejad, Mohammadmehdi Amin, Roya Kelishadi
Di (ethylhexyl) phthalate (DEHP) is a global environmental pollutant. This study aims to systematically review the literature on health effects of exposure to DEHP including effects on reproductive health, carcinogenesis, pregnancy outcome, and respiratory system. The literature search was done through Scopus, ISI Web of Science, Google Scholar, PubMed, Medline, and the reference lists of previous review articles to identify relevant articles published to June 2016 in each subject area. The inclusion criteria were as follows: original research, cross-sectional studies, case-control studies, cohort studies, interventional studies, and review articles...
October 6, 2016: Environmental Science and Pollution Research International
Xiyu Ouyang, Jana M Weiss, Jacob de Boer, Marja H Lamoree, Pim E G Leonards
Household dust and laundry dryer lint are important indoor environmental matrices that may have notable health effects on humans due to chronic exposure. However, due to the sample complexity the studies conducted on these sample matrices until now were almost exclusively on the basis of target analysis. In this study, comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry (LC × LC-ToF MS) was applied, to enable non-target analysis of household dust as well as laundry dryer lint for the first time...
January 2017: Chemosphere
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"