Dhanunjaya Lakkireddy, Adnan Ahmed, Donita Atkins, Danish Bawa, Jalaj Garg, Jenny Bush, Rishi Charate, Sudha Bommana, Naga Venkata K Pothineni, Rajesh Kabra, Douglas Darden, Scott Koreber, Rangarao Tummala, Chandrashekar Vasamreddy, Peter Park, Sanghamitra Mohanty, Rakesh Gopinathannair, B Woun Seo, Andrea Natale, Robert Kennedy
BACKGROUND: Inpatient initiation of sotalol is recommended owing to its proarrhythmic effects. The DASH-AF (Feasibility and Safety of Intravenous Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy in Adult Patients With Atrial Fibrillation) trial evaluates the safety and feasibility of intravenous (IV) sotalol, achieving a steady state with maximum QTc prolongation within 6 hours instead of the traditional 5-dose inpatient oral (PO) titration. METHODS: DASH-AF is a prospective, nonrandomized, multicenter, open-label trial consisting of patients who underwent IV sotalol loading dose to initiate rapid oral therapy for atrial arrhythmias...
January 7, 2023: JACC. Clinical Electrophysiology